iobenguane (123I) 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
iodine-containing contrast media 1448 139755-80-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • iobenguane sulfate I-123
  • iobenguane I-123
  • iobenguane
  • iobenguane I 123
  • iobenguane sulfate I 123
  • iobenguane (123I)
  • iobenguane sulfate
  • Molecular weight: 271.10
  • Formula: C8H10IN3
  • CLOGP: 1.55
  • LIPINSKI: None
  • HAC: 3
  • HDO: 3
  • TPSA: 61.90
  • ALOGS: -3.44
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AKT1,AKT2,AKT3,ALK,AURKA,AURKB,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK4,CDK5,CDK9,CHEK1,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHA2,EPHB4,ERBB2,FGFR1,FLT3,GRK2,GSK3B,IGF1R,IKBKB,INSR,IRAK1,ITK,JAK1,JAK2,JAK3,KIT,MAP2K1,MAP2K6,MAP3K1,MAP3K10,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK1,MAPK10,MAPK12,MAPK14,MAPK7,MAPK9,MAPKAPK2,MARK4,MELK,MET,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIM2,PLK1,PRKCD,PRKDC,SGK1,SIK2,SIK3,STK10,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2,ZAP70 83
kinase-selectivity-class AXL,BRAF,CDK9,DDR1,EIF2AK3,EPHB4,GRK2,GRK3,GSK3A,MAP3K10,MAP3K21,MAPK1,MAPK12,MAPK7,SIK2,STK33,TEK 17
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Sept. 19, 2008 FDA GE HEALTHCARE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC V09IX01 VARIOUS
DIAGNOSTIC RADIOPHARMACEUTICALS
TUMOUR DETECTION
Other diagnostic radiopharmaceuticals for tumour detection
FDA MoA N0000000205 Radiopharmaceutical Activity
FDA EPC N0000177914 Radioactive Diagnostic Agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent

Related Drugs by ATC class:

V09IX Other diagnostic radiopharmaceuticals for tumour detection 10 drugs
fluciclovine (18F)fludeoxyglucose (18F)fluorodopa (18F)fluoroestradiol F 18fluoroethylcholine (18F)gallium (68Ga) edotreotidegallium (68Ga) gozetotideiobenguane (131I)methioninesodium fluoride F-18

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.06 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4027963 VUID
N0000177925 NUI
D04557 KEGG_DRUG
76924-93-1 SECONDARY_CAS_RN
80663-95-2 SECONDARY_CAS_RN
4027963 VANDF
4027964 VANDF
CHEBI:135134 CHEBI
YMN PDB_CHEM_ID
CHEMBL1615777 ChEMBL_ID
CHEMBL3989523 ChEMBL_ID
CHEMBL818 ChEMBL_ID
87862-25-7 SECONDARY_CAS_RN
DB09546 DRUGBANK_ID
DB06704 DRUGBANK_ID
1426748 RXNORM
30506 MMSL
d05732 MMSL
014086 NDDF
395786000 SNOMEDCT_US
395787009 SNOMEDCT_US
439003007 SNOMEDCT_US
C2369192 UMLSCUI
135326 PUBCHEM_CID
23X1185WBO UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
AdreView HUMAN PRESCRIPTION DRUG LABEL 1 17156-235 INJECTION 2 mCi INTRAVENOUS NDA 27 sections
i 123 MIBGmeta iodobenzylguanidine HUMAN PRESCRIPTION DRUG LABEL 1 51808-103 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 25 mCi INTRAVENOUS Unapproved drug other 8 sections