ibudilast 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antiasthmatics or antiallergics, not acting primarily as antihistaminics anti-allergic or anti-inflammatory, not acting as anti-histaminics | 1406 | 50847-11-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| May 1, 1989 | PMDA | Kyorin Pharmaceutical |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Body tinea | 214.38 | 152.83 | 32 | 728 | 1351 | 70926333 |
| Infection susceptibility increased | 190.08 | 152.83 | 32 | 728 | 2925 | 70924759 |
| Inhibitory drug interaction | 175.31 | 152.83 | 31 | 729 | 3776 | 70923908 |
| Glucose tolerance impaired | 163.44 | 152.83 | 32 | 728 | 6774 | 70920910 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | R03DC04 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES Leukotriene receptor antagonists |
| MeSH PA | D018927 | Anti-Asthmatic Agents |
| MeSH PA | D001993 | Bronchodilator Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D006401 | Hematologic Agents |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D010726 | Phosphodiesterase Inhibitors |
| MeSH PA | D010975 | Platelet Aggregation Inhibitors |
| MeSH PA | D019141 | Respiratory System Agents |
| MeSH PA | D014665 | Vasodilator Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Asthma | indication | 195967001 | DOID:2841 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.86 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Enzyme | IC50 | 7.19 | CHEMBL | |||||
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A | Enzyme | IC50 | 7.27 | CHEMBL | |||||
| cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Enzyme | IC50 | 6.78 | CHEMBL | |||||
| cAMP-specific 3',5'-cyclic phosphodiesterase 4C | Enzyme | IC50 | 6.62 | CHEMBL | |||||
| Macrophage migration inhibitory factor | Unclassified | Kd | 5.85 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D01385 | KEGG_DRUG |
| C0123047 | UMLSCUI |
| CHEBI:31684 | CHEBI |
| CHEMBL19449 | ChEMBL_ID |
| DB05266 | DRUGBANK_ID |
| CHEMBL395091 | ChEMBL_ID |
| 3671 | PUBCHEM_CID |
| C038366 | MESH_SUPPLEMENTAL_RECORD_UI |
| 7399 | IUPHAR_LIGAND_ID |
| 6068 | INN_ID |
| M0TTH61XC5 | UNII |
| 010937 | NDDF |
| AVL | PDB_CHEM_ID |
Pharmaceutical products:
None