Stem definition | Drug id | CAS RN |
---|---|---|
antiasthmatics or antiallergics, not acting primarily as antihistaminics anti-allergic or anti-inflammatory, not acting as anti-histaminics | 1406 | 50847-11-5 |
Molecule | Description |
---|---|
Synonyms:
|
|
None
None
Date | Agency | Company | Orphan |
---|---|---|---|
May 1, 1989 | PMDA | Kyorin Pharmaceutical |
None
None
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Body tinea | 214.38 | 152.83 | 32 | 728 | 1351 | 70926333 |
Infection susceptibility increased | 190.08 | 152.83 | 32 | 728 | 2925 | 70924759 |
Inhibitory drug interaction | 175.31 | 152.83 | 31 | 729 | 3776 | 70923908 |
Glucose tolerance impaired | 163.44 | 152.83 | 32 | 728 | 6774 | 70920910 |
None
Source | Code | Description |
---|---|---|
ATC | R03DC04 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES Leukotriene receptor antagonists |
MeSH PA | D018927 | Anti-Asthmatic Agents |
MeSH PA | D001993 | Bronchodilator Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D006401 | Hematologic Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D010726 | Phosphodiesterase Inhibitors |
MeSH PA | D010975 | Platelet Aggregation Inhibitors |
MeSH PA | D019141 | Respiratory System Agents |
MeSH PA | D014665 | Vasodilator Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Asthma | indication | 195967001 | DOID:2841 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 3.86 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Enzyme | IC50 | 7.19 | CHEMBL | |||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4A | Enzyme | IC50 | 7.27 | CHEMBL | |||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Enzyme | IC50 | 6.78 | CHEMBL | |||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4C | Enzyme | IC50 | 6.62 | CHEMBL | |||||
Macrophage migration inhibitory factor | Unclassified | Kd | 5.85 | CHEMBL |
ID | Source |
---|---|
D01385 | KEGG_DRUG |
C0123047 | UMLSCUI |
CHEBI:31684 | CHEBI |
CHEMBL19449 | ChEMBL_ID |
DB05266 | DRUGBANK_ID |
CHEMBL395091 | ChEMBL_ID |
3671 | PUBCHEM_CID |
C038366 | MESH_SUPPLEMENTAL_RECORD_UI |
7399 | IUPHAR_LIGAND_ID |
6068 | INN_ID |
M0TTH61XC5 | UNII |
010937 | NDDF |
AVL | PDB_CHEM_ID |
None