hyoscyamine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
atropine derivatives 1402 101-31-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hyoscyamine hydrobromide
  • hyoscyamine
  • (-)-Atropine
  • (-)-Hyoscyamine
  • L-Hyoscyamin
  • L-Hyoscyamine
  • l-Atropine
  • hyoscyamine sulfate
The 3(S)-endo isomer of atropine.
  • Molecular weight: 289.38
  • Formula: C17H23NO3
  • CLOGP: 1.30
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 49.77
  • ALOGS: -2.06
  • ROTB: 5

Drug dosage:

DoseUnitRoute
1.20 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 2000 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 57 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.00 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1869 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cholecystitis chronic 146.69 13.78 59 11394 10302 63467267
Biliary dyskinesia 73.71 13.78 25 11428 2704 63474865
Gallbladder disorder 67.06 13.78 42 11411 18800 63458769
Abdominal pain 44.62 13.78 135 11318 293321 63184248
Anticholinergic syndrome 35.21 13.78 14 11439 2368 63475201
Emotional distress 33.39 13.78 35 11418 32514 63445055
Vision blurred 32.54 13.78 59 11394 91865 63385704
Anxiety 30.17 13.78 97 11356 217444 63260125
Drug ineffective 28.78 13.78 95 11358 1044670 62432899
Injury 28.49 13.78 49 11404 73198 63404371
Spleen congestion 27.53 13.78 6 11447 119 63477450
Colitis ulcerative 26.66 13.78 28 11425 26063 63451506
Cholelithiasis 26.45 13.78 36 11417 43889 63433680
Drug intolerance 25.35 13.78 12 11441 308649 63168920
Joint swelling 23.62 13.78 15 11438 327651 63149918
Depression 22.32 13.78 82 11371 196410 63281159
Diarrhoea 21.10 13.78 209 11244 715157 62762412
Muscle spasms 21.06 13.78 69 11384 156081 63321488
Dizziness 19.83 13.78 139 11314 429786 63047783
Asthma 19.62 13.78 59 11394 127502 63350067
Aortic valve calcification 18.83 13.78 6 11447 533 63477036
Abdominal distension 18.26 13.78 45 11408 86570 63390999
Biliary colic 17.95 13.78 10 11443 3607 63473962
Gallbladder injury 16.40 13.78 7 11446 1416 63476153
Off label use 16.06 13.78 65 11388 674397 62803172
Cystitis interstitial 15.58 13.78 7 11446 1601 63475968
Abdominal pain upper 15.52 13.78 76 11377 206368 63271201
Arthropathy 15.26 13.78 12 11441 234780 63242789
Haemorrhoids 14.63 13.78 19 11434 22131 63455438
Systemic lupus erythematosus 14.45 13.78 10 11443 208908 63268661
Blood testosterone decreased 13.94 13.78 3 11450 56 63477513

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Abdominal pain 27.99 19.77 48 2724 163570 34790589
Faecal calprotectin abnormal 22.84 19.77 5 2767 237 34953922

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cholecystitis chronic 147.46 14.16 53 9917 9853 79724565
Gallbladder disorder 71.93 14.16 39 9931 19301 79715117
Biliary dyskinesia 67.32 14.16 21 9949 2524 79731894
Abdominal pain 37.17 14.16 120 9850 389449 79344969
Anticholinergic syndrome 34.54 14.16 14 9956 3597 79730821
Emotional distress 34.33 14.16 33 9937 39936 79694482
Vision blurred 32.45 14.16 52 9918 105846 79628572
Injury 32.33 14.16 44 9926 77452 79656966
Cholelithiasis 30.10 14.16 35 9935 52629 79681789
Muscle spasms 26.73 14.16 64 9906 174666 79559752
Colitis ulcerative 26.70 14.16 27 9943 34715 79699703
Anxiety 25.91 14.16 79 9891 248433 79485985
Dizziness 23.83 14.16 129 9841 526312 79208106
Urinary tract infection 20.45 14.16 78 9892 274434 79459984
Diarrhoea 19.85 14.16 182 9788 880307 78854111
Abdominal pain upper 18.69 14.16 66 9904 223753 79510665
Spleen congestion 17.45 14.16 5 9965 449 79733969
Gallbladder injury 16.18 14.16 6 9964 1215 79733203
Depression 15.65 14.16 61 9909 216729 79517689
Dry mouth 15.39 14.16 34 9936 87985 79646433
Pain 15.08 14.16 144 9826 703658 79030760
Aortic valve calcification 14.85 14.16 5 9965 765 79733653
Completed suicide 14.49 14.16 65 9905 245702 79488716

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A03BA03 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
BELLADONNA AND DERIVATIVES, PLAIN
Belladonna alkaloids, tertiary amines
ATC A03CB31 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
ANTISPASMODICS IN COMBINATION WITH PSYCHOLEPTICS
Belladonna and derivatives in combination with psycholeptics
CHEBI has role CHEBI:76924 plant metabolites
MeSH PA D000759 Adjuvants, Anesthesia
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D001993 Bronchodilator Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D018678 Cholinergic Agents
MeSH PA D018680 Cholinergic Antagonists
MeSH PA D018727 Muscarinic Antagonists
MeSH PA D009184 Mydriatics
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D010276 Parasympatholytics
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D019141 Respiratory System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Peptic ulcer indication 13200003 DOID:750
Dysuria indication 49650001
Sinus bradycardia indication 49710005
Excessive salivation indication 53827007
Gastrointestinal Radiography Adjunct indication
Muscarine Toxicity indication
Cholinesterase Inhibitors Toxicity indication
Urinary Tract Irritation indication
Irritable bowel syndrome off-label use 10743008 DOID:9778
Diarrhea off-label use 62315008
Urinary incontinence off-label use 165232002
Neurogenic bladder off-label use 398064005
Brain damage contraindication 2470005
Ocular hypertension contraindication 4210003 DOID:9282
Gastritis contraindication 4556007 DOID:4029
Hypocalcemia contraindication 5291005
Tachyarrhythmia contraindication 6285003
Suicidal thoughts contraindication 6471006
Urinary tract obstruction contraindication 7163005 DOID:5200
Alcoholism contraindication 7200002
Hyperammonemia contraindication 9360008
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Hepatic encephalopathy contraindication 13920009 DOID:13413
Severe chronic ulcerative colitis contraindication 14311001
Disorder of autonomic nervous system contraindication 15241006
Cirrhosis of liver contraindication 19943007 DOID:5082
Hyperphosphatemia contraindication 20165001 DOID:0050459
Glaucoma contraindication 23986001 DOID:1686
Toxic megacolon contraindication 28536002 DOID:1770
Atony of colon contraindication 29479008
Hyperthyroidism contraindication 34486009 DOID:7998
Depressive disorder contraindication 35489007
Glomerulonephritis contraindication 36171008 DOID:2921
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Hypernatremia contraindication 39355002
Hypovolemic shock contraindication 39419009
Gastrointestinal ulcer contraindication 40845000
Complete trisomy 21 syndrome contraindication 41040004 DOID:14250
Body fluid retention contraindication 43498006
Hyperactive behavior contraindication 44548000
Uremia contraindication 44730006 DOID:4676
Conduction disorder of the heart contraindication 44808001
Achalasia of esophagus contraindication 45564002 DOID:9164
Chronic heart failure contraindication 48447003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Paralytic ileus contraindication 55525008 DOID:8442
Peptic reflux disease contraindication 57643001
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Ulcerative colitis contraindication 64766004 DOID:8577
Blood coagulation disorder contraindication 64779008 DOID:1247
Poisoning by phenobarbital contraindication 64921004
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Substance abuse contraindication 66214007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Sleep apnea contraindication 73430006 DOID:0050847
Factor II deficiency contraindication 73975000
Gastrointestinal hemorrhage contraindication 74474003
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Spastic paralysis contraindication 78403003
Disturbance of salivary secretion contraindication 78948009
Chronic idiopathic constipation contraindication 82934008
Hiatal hernia contraindication 84089009 DOID:12642
Kidney disease contraindication 90708001 DOID:557
Thyrotoxicosis contraindication 90739004 DOID:7997
Hemophilia contraindication 90935002
Myasthenia gravis contraindication 91637004 DOID:437
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Gastrointestinal obstruction contraindication 126765001
Autonomic dysreflexia contraindication 129618003
Bleeding contraindication 131148009
Liver function tests abnormal contraindication 166603001
Myocardial dysfunction contraindication 233928007
Gastroesophageal reflux disease contraindication 235595009 DOID:8534
Disease of liver contraindication 235856003 DOID:409
Bladder outflow obstruction contraindication 236645006
Pyloric obstruction contraindication 244815007
Sleep automatism contraindication 247962006
Benign prostatic hyperplasia contraindication 266569009
Dyspnea contraindication 267036007
Edema contraindication 267038008
Retention of urine contraindication 267064002
Anemia contraindication 271737000 DOID:2355
Drowsy contraindication 271782001
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Angle-closure glaucoma contraindication 392291006 DOID:13550
Cardiovascular event risk contraindication 395112001
Gastric ulcer contraindication 397825006 DOID:10808
Respiratory insufficiency contraindication 409623005
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Disorder of coronary artery contraindication 414024009
Porphyria contraindication 418470004
Fever greater than 100.4 Fahrenheit contraindication 426000000
Hypertensive urgency contraindication 443482000
Severe dehydration contraindication 450316000
Acute exacerbation of asthma contraindication 708038006




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.24 acidic
pKa2 9.26 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Muscarinic acetylcholine receptor M1 GPCR ANTAGONIST Ki 9 WOMBAT-PK KEGG DRUG
Muscarinic acetylcholine receptor M2 GPCR ANTAGONIST Ki 9.30 WOMBAT-PK KEGG DRUG
Muscarinic acetylcholine receptor M3 GPCR ANTAGONIST Ki 9.80 WOMBAT-PK KEGG DRUG
Muscarinic acetylcholine receptor M4 GPCR Ki 9.90 WOMBAT-PK
Muscarinic acetylcholine receptor M5 GPCR Ki 9.20 WOMBAT-PK

External reference:

IDSource
4018400 VUID
N0000189428 NUI
D00147 KEGG_DRUG
306-03-6 SECONDARY_CAS_RN
6835-16-1 SECONDARY_CAS_RN
4018398 VANDF
4018400 VANDF
4018402 VANDF
C0596004 UMLSCUI
CHEBI:17486 CHEBI
CHEMBL1331216 ChEMBL_ID
CHEMBL2106364 ChEMBL_ID
DB00424 DRUGBANK_ID
CHEMBL1257084 ChEMBL_ID
CHEMBL3989570 ChEMBL_ID
CHEMBL1697729 ChEMBL_ID
D064692 MESH_DESCRIPTOR_UI
174174 PUBCHEM_CID
PX44XO846X UNII
1047802 RXNORM
20634 MMSL
4860 MMSL
4861 MMSL
4949 MMSL
6292 MMSL
71952 MMSL
72595 MMSL
d00985 MMSL
001727 NDDF
001728 NDDF
001729 NDDF
372757002 SNOMEDCT_US
387391003 SNOMEDCT_US
48899009 SNOMEDCT_US
56085009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
URELLE HUMAN PRESCRIPTION DRUG LABEL 5 0037-6321 TABLET 0.12 mg ORAL Unapproved drug other 12 sections
Levsin HUMAN PRESCRIPTION DRUG LABEL 1 0037-9001 INJECTION, SOLUTION 0.50 mg SUBCUTANEOUS Unapproved drug other 11 sections
Levsin HUMAN PRESCRIPTION DRUG LABEL 1 0037-9001 INJECTION, SOLUTION 0.50 mg SUBCUTANEOUS Unapproved drug other 11 sections
URIBEL HUMAN PRESCRIPTION DRUG LABEL 5 0076-0111 CAPSULE 0.12 mg ORAL unapproved drug other 20 sections
Hyophen HUMAN PRESCRIPTION DRUG LABEL 5 0076-0901 TABLET 0.12 mg ORAL unapproved drug other 19 sections
Phosphasal HUMAN PRESCRIPTION DRUG LABEL 5 0076-0902 TABLET 0.12 mg ORAL unapproved drug other 20 sections
Ustell HUMAN PRESCRIPTION DRUG LABEL 5 0076-0903 CAPSULE 0.12 mg ORAL unapproved drug other 20 sections
Utira-C HUMAN PRESCRIPTION DRUG LABEL 5 0178-0513 TABLET 0.12 mg ORAL unapproved drug other 12 sections
Utira-C HUMAN PRESCRIPTION DRUG LABEL 5 0178-0513 TABLET 0.12 mg ORAL unapproved drug other 12 sections
URIBEL HUMAN PRESCRIPTION DRUG LABEL 5 0178-0740 CAPSULE 0.12 mg ORAL unapproved drug other 21 sections
URIBEL HUMAN PRESCRIPTION DRUG LABEL 5 0178-0740 CAPSULE 0.12 mg ORAL unapproved drug other 21 sections
ANASPAZ HUMAN PRESCRIPTION DRUG LABEL 1 0225-0295 TABLET, ORALLY DISINTEGRATING 0.13 mg SUBLINGUAL unapproved drug other 21 sections
Belladonna Alkaloids with Phenobartbital HUMAN PRESCRIPTION DRUG LABEL 4 0440-7183 TABLET 0.10 mg ORAL UNAPPROVED DRUG OTHER 14 sections
ED-SPAZ HUMAN PRESCRIPTION DRUG LABEL 1 0485-0082 TABLET, ORALLY DISINTEGRATING 0.13 mg ORAL unapproved drug other 20 sections
UROGESIC BLUE HUMAN PRESCRIPTION DRUG LABEL 4 0485-0151 TABLET, COATED 0.12 mg ORAL unapproved drug other 18 sections
UROGESIC BLUE HUMAN PRESCRIPTION DRUG LABEL 4 0485-0151 TABLET, COATED 0.12 mg ORAL unapproved drug other 18 sections
UROGESIC BLUE HUMAN PRESCRIPTION DRUG LABEL 4 0485-0151 TABLET, COATED 0.12 mg ORAL unapproved drug other 18 sections
UROGESIC BLUE HUMAN PRESCRIPTION DRUG LABEL 4 0485-0151 TABLET, COATED 0.12 mg ORAL unapproved drug other 18 sections
Uretron D/S HUMAN PRESCRIPTION DRUG LABEL 5 12539-144 TABLET 0.12 mg ORAL unapproved drug other 20 sections
UroAv-81 HUMAN PRESCRIPTION DRUG LABEL 5 15338-502 TABLET 0.12 mg ORAL unapproved drug other 18 sections
UroAv-B HUMAN PRESCRIPTION DRUG LABEL 5 15338-503 CAPSULE 0.12 mg ORAL unapproved drug other 18 sections
Phenohytro HUMAN PRESCRIPTION DRUG LABEL 4 17856-0123 ELIXIR 0.10 mg ORAL UNAPPROVED DRUG OTHER 18 sections
Phenohytro HUMAN PRESCRIPTION DRUG LABEL 4 17856-0125 ELIXIR 0.10 mg ORAL UNAPPROVED DRUG OTHER 18 sections
Phenohytro HUMAN PRESCRIPTION DRUG LABEL 4 17856-0125 ELIXIR 0.10 mg ORAL UNAPPROVED DRUG OTHER 18 sections
PHENOBARBITAL WITH BELLADONNA ALKALOIDS HUMAN PRESCRIPTION DRUG LABEL 4 17856-0162 ELIXIR 0.10 mg ORAL unapproved drug other 16 sections
Donnatal HUMAN PRESCRIPTION DRUG LABEL 4 17856-0423 ELIXIR 0.10 mg ORAL unapproved drug other 12 sections
Hyosyne HUMAN PRESCRIPTION DRUG LABEL 1 17856-0511 ELIXIR 0.13 mg ORAL unapproved drug other 11 sections
Hyosyne HUMAN PRESCRIPTION DRUG LABEL 1 17856-0514 ELIXIR 0.13 mg ORAL unapproved drug other 11 sections
Hyoscyamine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 21695-442 TABLET 0.13 mg ORAL Unapproved drug other 18 sections
RE-PB HYOS ELIXIR HUMAN PRESCRIPTION DRUG LABEL 4 21695-594 ELIXIR 0.10 mg ORAL Unapproved drug other 11 sections