Stem definition | Drug id | CAS RN |
---|---|---|
diphenylmethyl piperazine derivatives | 1400 | 68-88-2 |
Dose | Unit | Route |
---|---|---|
75 | mg | O |
75 | mg | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 700 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0.10 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 15.24 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 80 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
April 12, 1956 | FDA | PFIZER |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 819.29 | 10.13 | 880 | 57649 | 131009 | 50415586 |
Intentional overdose | 335.42 | 10.13 | 387 | 58142 | 62117 | 50484478 |
Intentional self-injury | 294.26 | 10.13 | 231 | 58298 | 22881 | 50523714 |
Toxicity to various agents | 288.70 | 10.13 | 708 | 57821 | 211791 | 50334804 |
Urticaria | 211.14 | 10.13 | 464 | 58065 | 129097 | 50417498 |
Pruritus | 206.59 | 10.13 | 758 | 57771 | 282810 | 50263785 |
Drug abuse | 199.42 | 10.13 | 293 | 58236 | 59553 | 50487042 |
Cardio-respiratory arrest | 134.18 | 10.13 | 231 | 58298 | 53661 | 50492934 |
Poisoning | 128.30 | 10.13 | 110 | 58419 | 12319 | 50534276 |
Respiratory arrest | 127.09 | 10.13 | 165 | 58364 | 29844 | 50516751 |
Pemphigus | 124.63 | 10.13 | 3 | 58526 | 120163 | 50426432 |
Contraindicated product administered | 120.88 | 10.13 | 15 | 58514 | 148943 | 50397652 |
Treatment failure | 113.81 | 10.13 | 13 | 58516 | 137624 | 50408971 |
Synovitis | 112.34 | 10.13 | 8 | 58521 | 123857 | 50422738 |
Joint swelling | 111.98 | 10.13 | 73 | 58456 | 245213 | 50301382 |
Rheumatoid arthritis | 105.80 | 10.13 | 51 | 58478 | 202499 | 50344096 |
Systemic lupus erythematosus | 105.20 | 10.13 | 18 | 58511 | 140604 | 50405991 |
Poisoning deliberate | 104.82 | 10.13 | 81 | 58448 | 7831 | 50538764 |
Glossodynia | 100.52 | 10.13 | 9 | 58520 | 115560 | 50431035 |
Drug dependence | 95.37 | 10.13 | 116 | 58413 | 19643 | 50526952 |
Anxiety | 90.56 | 10.13 | 426 | 58103 | 177180 | 50369415 |
Cardiac arrest | 90.07 | 10.13 | 256 | 58273 | 83395 | 50463200 |
Suicide attempt | 89.52 | 10.13 | 190 | 58339 | 51542 | 50495053 |
Drug intolerance | 83.77 | 10.13 | 78 | 58451 | 219026 | 50327569 |
Dermatitis atopic | 81.14 | 10.13 | 51 | 58478 | 3535 | 50543060 |
Anticholinergic syndrome | 80.43 | 10.13 | 40 | 58489 | 1755 | 50544840 |
Arthropathy | 76.17 | 10.13 | 44 | 58485 | 157862 | 50388733 |
Burning mouth syndrome | 66.05 | 10.13 | 23 | 58506 | 400 | 50546195 |
Somnolence | 65.05 | 10.13 | 352 | 58177 | 154633 | 50391962 |
Suicidal ideation | 65.04 | 10.13 | 175 | 58354 | 55210 | 50491385 |
Therapeutic product effect decreased | 64.07 | 10.13 | 39 | 58490 | 136011 | 50410584 |
Abdominal discomfort | 62.93 | 10.13 | 107 | 58422 | 231534 | 50315061 |
Electrocardiogram QT prolonged | 61.99 | 10.13 | 165 | 58364 | 51721 | 50494874 |
Wound | 61 | 10.13 | 23 | 58506 | 105771 | 50440824 |
Skin plaque | 59.27 | 10.13 | 53 | 58476 | 6275 | 50540320 |
Irritability | 56.99 | 10.13 | 111 | 58418 | 28315 | 50518280 |
Drug reaction with eosinophilia and systemic symptoms | 55.78 | 10.13 | 110 | 58419 | 28314 | 50518281 |
Hepatic enzyme increased | 54.75 | 10.13 | 47 | 58482 | 137333 | 50409262 |
Psoriasis | 53.86 | 10.13 | 189 | 58340 | 68811 | 50477784 |
Eczema | 53.46 | 10.13 | 95 | 58434 | 22607 | 50523988 |
Infusion related reaction | 52.10 | 10.13 | 72 | 58457 | 169485 | 50377110 |
Chronic spontaneous urticaria | 50.54 | 10.13 | 20 | 58509 | 504 | 50546091 |
Angioedema | 50.36 | 10.13 | 125 | 58404 | 37551 | 50509044 |
Urticaria thermal | 49.79 | 10.13 | 15 | 58514 | 160 | 50546435 |
Maternal exposure during pregnancy | 46.96 | 10.13 | 70 | 58459 | 159708 | 50386887 |
Prescription form tampering | 45.59 | 10.13 | 19 | 58510 | 549 | 50546046 |
Scratch | 45.37 | 10.13 | 41 | 58488 | 4921 | 50541674 |
Chemical submission | 44.38 | 10.13 | 14 | 58515 | 176 | 50546419 |
Overdose | 44.20 | 10.13 | 230 | 58299 | 99497 | 50447098 |
Victim of chemical submission | 43.78 | 10.13 | 15 | 58514 | 248 | 50546347 |
Helicobacter infection | 42.85 | 10.13 | 4 | 58525 | 49698 | 50496897 |
Alopecia | 42.08 | 10.13 | 144 | 58385 | 244903 | 50301692 |
Bradypnoea | 39.69 | 10.13 | 31 | 58498 | 3043 | 50543552 |
Drug ineffective | 39.61 | 10.13 | 689 | 57840 | 818644 | 49727951 |
Lower respiratory tract infection | 38.62 | 10.13 | 32 | 58497 | 95169 | 50451426 |
Suspected suicide | 37.13 | 10.13 | 38 | 58491 | 5319 | 50541276 |
Depression | 37.10 | 10.13 | 322 | 58207 | 165101 | 50381494 |
Asphyxia | 36.71 | 10.13 | 38 | 58491 | 5389 | 50541206 |
Alcoholism | 36.55 | 10.13 | 23 | 58506 | 1597 | 50544998 |
Rash maculo-papular | 35.19 | 10.13 | 88 | 58441 | 26553 | 50520042 |
Drug screen positive | 34.88 | 10.13 | 30 | 58499 | 3372 | 50543223 |
Intentional product misuse | 34.74 | 10.13 | 126 | 58403 | 46608 | 50499987 |
Mastocytosis | 33.88 | 10.13 | 15 | 58514 | 504 | 50546091 |
Hallucination, gustatory | 33.11 | 10.13 | 9 | 58520 | 64 | 50546531 |
Urinary retention | 33.02 | 10.13 | 85 | 58444 | 26105 | 50520490 |
Multiple drug therapy | 32.81 | 10.13 | 23 | 58506 | 1914 | 50544681 |
Mixed liver injury | 32.51 | 10.13 | 29 | 58500 | 3422 | 50543173 |
Long QT syndrome | 32.13 | 10.13 | 27 | 58502 | 2940 | 50543655 |
Drug hypersensitivity | 31.00 | 10.13 | 434 | 58095 | 250576 | 50296019 |
Allergy test positive | 30.67 | 10.13 | 13 | 58516 | 392 | 50546203 |
Faecal vomiting | 29.28 | 10.13 | 14 | 58515 | 563 | 50546032 |
Serotonin syndrome | 28.91 | 10.13 | 78 | 58451 | 24635 | 50521960 |
Infection | 28.75 | 10.13 | 103 | 58426 | 172851 | 50373744 |
Musculoskeletal stiffness | 26.72 | 10.13 | 69 | 58460 | 128412 | 50418183 |
Metabolic acidosis | 26.62 | 10.13 | 102 | 58427 | 38723 | 50507872 |
Insomnia | 26.48 | 10.13 | 314 | 58215 | 174551 | 50372044 |
Agitation | 26.37 | 10.13 | 127 | 58402 | 53257 | 50493338 |
Parkinsonism | 26.15 | 10.13 | 41 | 58488 | 8806 | 50537789 |
Perfume sensitivity | 25.63 | 10.13 | 13 | 58516 | 595 | 50546000 |
Miosis | 25.62 | 10.13 | 34 | 58495 | 6276 | 50540319 |
Folliculitis | 25.30 | 10.13 | 7 | 58522 | 39218 | 50507377 |
Impaired healing | 25.29 | 10.13 | 26 | 58503 | 69760 | 50476835 |
Withdrawal syndrome | 24.18 | 10.13 | 59 | 58470 | 17531 | 50529064 |
General physical health deterioration | 23.55 | 10.13 | 85 | 58444 | 142349 | 50404246 |
Muscle injury | 23.24 | 10.13 | 7 | 58522 | 37104 | 50509491 |
Disturbance in attention | 23.10 | 10.13 | 84 | 58445 | 31102 | 50515493 |
Diet failure | 22.67 | 10.13 | 6 | 58523 | 38 | 50546557 |
Labile hypertension | 22.60 | 10.13 | 11 | 58518 | 460 | 50546135 |
Coma | 22.36 | 10.13 | 127 | 58402 | 56752 | 50489843 |
Psychotic symptom | 21.96 | 10.13 | 15 | 58514 | 1197 | 50545398 |
Altered state of consciousness | 21.58 | 10.13 | 65 | 58464 | 21845 | 50524750 |
Panic attack | 21.58 | 10.13 | 60 | 58469 | 19282 | 50527313 |
Dermatitis exfoliative generalised | 21.35 | 10.13 | 22 | 58507 | 3104 | 50543491 |
Neutropenia | 20.87 | 10.13 | 94 | 58435 | 147871 | 50398724 |
Blood immunoglobulin E increased | 20.61 | 10.13 | 19 | 58510 | 2340 | 50544255 |
Nodular rash | 20.39 | 10.13 | 8 | 58521 | 197 | 50546398 |
Product dose omission issue | 20.35 | 10.13 | 312 | 58217 | 183526 | 50363069 |
Interstitial lung disease | 20.20 | 10.13 | 19 | 58510 | 53157 | 50493438 |
Lymphomatoid papulosis | 20.20 | 10.13 | 7 | 58522 | 120 | 50546475 |
Joint ankylosis | 20.19 | 10.13 | 12 | 58517 | 752 | 50545843 |
Hereditary angioedema | 20.09 | 10.13 | 28 | 58501 | 5414 | 50541181 |
Pancreatitis | 20.06 | 10.13 | 100 | 58429 | 42514 | 50504081 |
Sleep disorder | 20.01 | 10.13 | 124 | 58405 | 57159 | 50489436 |
Plasma cell myeloma | 19.45 | 10.13 | 6 | 58523 | 31316 | 50515279 |
Distributive shock | 19.14 | 10.13 | 12 | 58517 | 828 | 50545767 |
Off label use | 19.11 | 10.13 | 411 | 58118 | 474015 | 50072580 |
Decreased eye contact | 19.10 | 10.13 | 8 | 58521 | 234 | 50546361 |
Migraine | 18.69 | 10.13 | 150 | 58379 | 75130 | 50471465 |
Photosensitivity reaction | 18.49 | 10.13 | 44 | 58485 | 12867 | 50533728 |
Depressed level of consciousness | 18.48 | 10.13 | 113 | 58416 | 51840 | 50494755 |
Arthralgia | 18.26 | 10.13 | 378 | 58151 | 438324 | 50108271 |
Binge eating | 18.24 | 10.13 | 9 | 58520 | 388 | 50546207 |
Cold agglutinins positive | 18.10 | 10.13 | 5 | 58524 | 38 | 50546557 |
Sensitivity to weather change | 18.00 | 10.13 | 28 | 58501 | 5973 | 50540622 |
Toxic skin eruption | 17.94 | 10.13 | 40 | 58489 | 11211 | 50535384 |
Red blood cell sedimentation rate increased | 17.62 | 10.13 | 6 | 58523 | 29410 | 50517185 |
Akathisia | 17.55 | 10.13 | 33 | 58496 | 8196 | 50538399 |
Aggression | 17.47 | 10.13 | 59 | 58470 | 21057 | 50525538 |
Skin lesion | 17.33 | 10.13 | 69 | 58460 | 26658 | 50519937 |
Burnout syndrome | 17.20 | 10.13 | 7 | 58522 | 190 | 50546405 |
Anaemia | 17.15 | 10.13 | 198 | 58331 | 252258 | 50294337 |
Feeling abnormal | 17.11 | 10.13 | 221 | 58308 | 125271 | 50421324 |
Papule | 17.01 | 10.13 | 23 | 58506 | 4322 | 50542273 |
Hyperleukocytosis | 16.91 | 10.13 | 9 | 58520 | 455 | 50546140 |
Pneumonia | 16.65 | 10.13 | 323 | 58206 | 378078 | 50168517 |
Derailment | 16.62 | 10.13 | 5 | 58524 | 53 | 50546542 |
Dementia | 16.27 | 10.13 | 48 | 58481 | 15949 | 50530646 |
Emotional distress | 16.24 | 10.13 | 71 | 58458 | 28592 | 50518003 |
Wound secretion | 16.17 | 10.13 | 21 | 58508 | 3796 | 50542799 |
Lip erythema | 16.09 | 10.13 | 6 | 58523 | 128 | 50546467 |
Wrong technique in device usage process | 16.09 | 10.13 | 17 | 58512 | 2469 | 50544126 |
Mast cell activation syndrome | 15.92 | 10.13 | 8 | 58521 | 359 | 50546236 |
Temperature intolerance | 15.79 | 10.13 | 30 | 58499 | 7509 | 50539086 |
Irritable bowel syndrome | 15.62 | 10.13 | 22 | 58507 | 51419 | 50495176 |
Hip arthroplasty | 15.35 | 10.13 | 8 | 58521 | 30421 | 50516174 |
Blood cholesterol decreased | 15.01 | 10.13 | 10 | 58519 | 766 | 50545829 |
Mydriasis | 14.98 | 10.13 | 36 | 58493 | 10591 | 50536004 |
Injection site mass | 14.96 | 10.13 | 46 | 58483 | 15634 | 50530961 |
Drug withdrawal syndrome | 14.88 | 10.13 | 63 | 58466 | 25018 | 50521577 |
Linear IgA disease | 14.81 | 10.13 | 12 | 58517 | 1242 | 50545353 |
Discomfort | 14.59 | 10.13 | 70 | 58459 | 108310 | 50438285 |
Gastrointestinal disorder | 14.55 | 10.13 | 58 | 58471 | 94398 | 50452197 |
Stomatitis | 14.51 | 10.13 | 64 | 58465 | 101280 | 50445315 |
Superior mesenteric artery syndrome | 14.41 | 10.13 | 5 | 58524 | 86 | 50546509 |
Affect lability | 14.36 | 10.13 | 32 | 58497 | 8966 | 50537629 |
Apallic syndrome | 14.31 | 10.13 | 9 | 58520 | 624 | 50545971 |
Post-traumatic stress disorder | 14.21 | 10.13 | 21 | 58508 | 4282 | 50542313 |
Asthma | 14.21 | 10.13 | 162 | 58367 | 89175 | 50457420 |
Initial insomnia | 14.15 | 10.13 | 23 | 58506 | 5092 | 50541503 |
Tonsillar hypertrophy | 14.01 | 10.13 | 10 | 58519 | 856 | 50545739 |
Postural orthostatic tachycardia syndrome | 13.95 | 10.13 | 10 | 58519 | 862 | 50545733 |
Accidental overdose | 13.95 | 10.13 | 52 | 58477 | 19481 | 50527114 |
Dermatitis | 13.77 | 10.13 | 42 | 58487 | 14209 | 50532386 |
Cholestasis | 13.69 | 10.13 | 62 | 58467 | 25339 | 50521256 |
Exposure during pregnancy | 13.62 | 10.13 | 83 | 58446 | 120932 | 50425663 |
C-reactive protein increased | 13.58 | 10.13 | 36 | 58493 | 66438 | 50480157 |
Talipes | 13.55 | 10.13 | 12 | 58517 | 1402 | 50545193 |
Urticaria chronic | 13.46 | 10.13 | 8 | 58521 | 501 | 50546094 |
Skin discolouration | 13.44 | 10.13 | 74 | 58455 | 32683 | 50513912 |
Superior sagittal sinus thrombosis | 13.41 | 10.13 | 9 | 58520 | 698 | 50545897 |
Knee arthroplasty | 13.39 | 10.13 | 13 | 58516 | 35833 | 50510762 |
Illness | 13.31 | 10.13 | 60 | 58469 | 24480 | 50522115 |
Alpha 1 globulin increased | 13.27 | 10.13 | 5 | 58524 | 110 | 50546485 |
Transverse sinus thrombosis | 13.25 | 10.13 | 8 | 58521 | 516 | 50546079 |
Restless arm syndrome | 13.25 | 10.13 | 4 | 58525 | 43 | 50546552 |
Pleural effusion | 13.20 | 10.13 | 49 | 58480 | 81405 | 50465190 |
Fatigue | 13.16 | 10.13 | 677 | 57852 | 706924 | 49839671 |
Ehlers-Danlos syndrome | 13.02 | 10.13 | 5 | 58524 | 116 | 50546479 |
Hallucination, olfactory | 13.01 | 10.13 | 6 | 58523 | 222 | 50546373 |
Granulomatous liver disease | 13.00 | 10.13 | 9 | 58520 | 734 | 50545861 |
Eyelid haemangioma | 12.90 | 10.13 | 3 | 58526 | 10 | 50546585 |
Hypercreatininaemia | 12.80 | 10.13 | 7 | 58522 | 374 | 50546221 |
Exposure via ingestion | 12.79 | 10.13 | 16 | 58513 | 2787 | 50543808 |
Micrognathia | 12.70 | 10.13 | 6 | 58523 | 235 | 50546360 |
Hallucination, visual | 12.56 | 10.13 | 45 | 58484 | 16537 | 50530058 |
Social anxiety disorder | 12.46 | 10.13 | 7 | 58522 | 394 | 50546201 |
Dependence | 12.45 | 10.13 | 13 | 58516 | 1862 | 50544733 |
Pain of skin | 12.39 | 10.13 | 28 | 58501 | 7919 | 50538676 |
Malignant neoplasm progression | 12.38 | 10.13 | 39 | 58490 | 68085 | 50478510 |
Breast adenoma | 12.35 | 10.13 | 4 | 58525 | 55 | 50546540 |
Swelling | 12.33 | 10.13 | 161 | 58368 | 200711 | 50345884 |
Retrograde amnesia | 12.30 | 10.13 | 7 | 58522 | 404 | 50546191 |
Multiple fractures | 12.27 | 10.13 | 25 | 58504 | 6586 | 50540009 |
Alpha 2 globulin increased | 12.24 | 10.13 | 5 | 58524 | 137 | 50546458 |
Fat necrosis | 12.19 | 10.13 | 8 | 58521 | 597 | 50545998 |
Respiratory depression | 12.18 | 10.13 | 36 | 58493 | 11974 | 50534621 |
Erythema | 12.05 | 10.13 | 237 | 58292 | 146177 | 50400418 |
Substance abuse | 12.03 | 10.13 | 19 | 58510 | 4105 | 50542490 |
Iron deficiency | 11.88 | 10.13 | 23 | 58506 | 5839 | 50540756 |
Pneumonitis | 11.86 | 10.13 | 10 | 58519 | 29500 | 50517095 |
Negative thoughts | 11.76 | 10.13 | 9 | 58520 | 857 | 50545738 |
Bruxism | 11.76 | 10.13 | 16 | 58513 | 3024 | 50543571 |
Nightmare | 11.63 | 10.13 | 43 | 58486 | 16043 | 50530552 |
Herpes zoster meningoencephalitis | 11.56 | 10.13 | 6 | 58523 | 288 | 50546307 |
Pulmonary fibrosis | 11.50 | 10.13 | 7 | 58522 | 24430 | 50522165 |
Bronchial wall thickening | 11.41 | 10.13 | 9 | 58520 | 896 | 50545699 |
Drug interaction | 11.41 | 10.13 | 307 | 58222 | 199314 | 50347281 |
Dystonia | 11.39 | 10.13 | 35 | 58494 | 11891 | 50534704 |
Vascular stent thrombosis | 11.38 | 10.13 | 9 | 58520 | 900 | 50545695 |
Atrial fibrillation | 11.34 | 10.13 | 70 | 58459 | 101675 | 50444920 |
Gastrointestinal ischaemia | 11.10 | 10.13 | 5 | 58524 | 175 | 50546420 |
Blood pressure decreased | 11.07 | 10.13 | 106 | 58423 | 55803 | 50490792 |
Ventricular fibrillation | 11.04 | 10.13 | 32 | 58497 | 10527 | 50536068 |
Occipital neuralgia | 11.03 | 10.13 | 6 | 58523 | 317 | 50546278 |
Formication | 10.92 | 10.13 | 17 | 58512 | 3629 | 50542966 |
Tremor | 10.84 | 10.13 | 190 | 58339 | 114713 | 50431882 |
Osteonecrosis of jaw | 10.81 | 10.13 | 13 | 58516 | 32513 | 50514082 |
Breath odour | 10.80 | 10.13 | 10 | 58519 | 1238 | 50545357 |
Loss of personal independence in daily activities | 10.79 | 10.13 | 43 | 58486 | 70007 | 50476588 |
Bipolar disorder | 10.75 | 10.13 | 24 | 58505 | 6733 | 50539862 |
Product use in unapproved indication | 10.74 | 10.13 | 191 | 58338 | 115628 | 50430967 |
Sinusitis | 10.72 | 10.13 | 136 | 58393 | 170422 | 50376173 |
Acidosis | 10.70 | 10.13 | 31 | 58498 | 10196 | 50536399 |
Febrile bone marrow aplasia | 10.70 | 10.13 | 23 | 58506 | 6288 | 50540307 |
Gastrointestinal haemorrhage | 10.68 | 10.13 | 46 | 58483 | 73275 | 50473320 |
Tardive dyskinesia | 10.63 | 10.13 | 25 | 58504 | 7254 | 50539341 |
Neuropathy peripheral | 10.56 | 10.13 | 67 | 58462 | 96690 | 50449905 |
Hypertriglyceridaemia | 10.47 | 10.13 | 21 | 58508 | 5470 | 50541125 |
Mucosal inflammation | 10.46 | 10.13 | 19 | 58510 | 40123 | 50506472 |
Hypertonic bladder | 10.43 | 10.13 | 15 | 58514 | 2985 | 50543610 |
Eosinophilia | 10.41 | 10.13 | 46 | 58483 | 18606 | 50527989 |
Crying | 10.39 | 10.13 | 49 | 58480 | 20367 | 50526228 |
Activation syndrome | 10.39 | 10.13 | 5 | 58524 | 204 | 50546391 |
Staphylococcal skin infection | 10.37 | 10.13 | 8 | 58521 | 771 | 50545824 |
Thrombocytopenia | 10.35 | 10.13 | 96 | 58433 | 127577 | 50419018 |
Oedema mouth | 10.33 | 10.13 | 13 | 58516 | 2277 | 50544318 |
Peripheral circulatory failure | 10.29 | 10.13 | 7 | 58522 | 555 | 50546040 |
Therapeutic product effect incomplete | 10.17 | 10.13 | 63 | 58466 | 91452 | 50455143 |
Stress | 10.16 | 10.13 | 101 | 58428 | 53692 | 50492903 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 567 | 10.92 | 560 | 28353 | 89686 | 29455928 |
Toxicity to various agents | 317.79 | 10.92 | 590 | 28323 | 173071 | 29372543 |
Drug abuse | 142.42 | 10.92 | 269 | 28644 | 79614 | 29466000 |
Intentional overdose | 95.17 | 10.92 | 150 | 28763 | 38378 | 29507236 |
Respiratory arrest | 89.32 | 10.92 | 118 | 28795 | 25715 | 29519899 |
Pruritus | 80.39 | 10.92 | 274 | 28639 | 116575 | 29429039 |
Poisoning | 73.77 | 10.92 | 68 | 28845 | 9925 | 29535689 |
Cardio-respiratory arrest | 67.15 | 10.92 | 151 | 28762 | 50450 | 29495164 |
Coma | 66.68 | 10.92 | 130 | 28783 | 39320 | 29506294 |
Dermatitis atopic | 59.01 | 10.92 | 33 | 28880 | 2186 | 29543428 |
Suicidal behaviour | 58.57 | 10.92 | 28 | 28885 | 1337 | 29544277 |
Overdose | 55.55 | 10.92 | 188 | 28725 | 79631 | 29465983 |
Ventricular tachyarrhythmia | 52.43 | 10.92 | 17 | 28896 | 281 | 29545333 |
Urticaria | 50.35 | 10.92 | 142 | 28771 | 54518 | 29491096 |
Parasomnia | 48.86 | 10.92 | 17 | 28896 | 352 | 29545262 |
Drug reaction with eosinophilia and systemic symptoms | 48.21 | 10.92 | 93 | 28820 | 27899 | 29517715 |
Cardiac arrest | 48.05 | 10.92 | 188 | 28725 | 85403 | 29460211 |
Bradypnoea | 44.09 | 10.92 | 28 | 28885 | 2343 | 29543271 |
Hyperthermia | 43.79 | 10.92 | 50 | 28863 | 9380 | 29536234 |
Ureteric compression | 43.04 | 10.92 | 13 | 28900 | 168 | 29545446 |
Suspected suicide | 36.97 | 10.92 | 31 | 28882 | 3989 | 29541625 |
Priapism | 35.98 | 10.92 | 32 | 28881 | 4456 | 29541158 |
Intentional self-injury | 35.68 | 10.92 | 52 | 28861 | 12409 | 29533205 |
Chemical submission | 35.02 | 10.92 | 8 | 28905 | 30 | 29545584 |
Toxic epidermal necrolysis | 34.60 | 10.92 | 63 | 28850 | 18090 | 29527524 |
Electrocardiogram QT prolonged | 34.36 | 10.92 | 95 | 28818 | 36042 | 29509572 |
Alcoholism | 34.18 | 10.92 | 25 | 28888 | 2636 | 29542978 |
Exposure via ingestion | 30.65 | 10.92 | 21 | 28892 | 1997 | 29543617 |
Personal relationship issue | 29.87 | 10.92 | 11 | 28902 | 270 | 29545344 |
General physical health deterioration | 29.77 | 10.92 | 34 | 28879 | 102823 | 29442791 |
Somnolence | 28.49 | 10.92 | 173 | 28740 | 93782 | 29451832 |
Psoriasis | 27.99 | 10.92 | 82 | 28831 | 32145 | 29513469 |
Abnormal sleep-related event | 27.96 | 10.92 | 12 | 28901 | 444 | 29545170 |
Face oedema | 26.70 | 10.92 | 41 | 28872 | 10242 | 29535372 |
Clonus | 25.37 | 10.92 | 20 | 28893 | 2358 | 29543256 |
Haematoma muscle | 24.82 | 10.92 | 14 | 28899 | 943 | 29544671 |
Sensory integrative dysfunction | 24.70 | 10.92 | 6 | 28907 | 31 | 29545583 |
Non-cardiogenic pulmonary oedema | 24.31 | 10.92 | 12 | 28901 | 615 | 29544999 |
Postmortem blood drug level | 24.30 | 10.92 | 8 | 28905 | 139 | 29545475 |
Emotional disorder of childhood | 24.24 | 10.92 | 6 | 28907 | 34 | 29545580 |
Dermatitis exfoliative generalised | 23.79 | 10.92 | 21 | 28892 | 2895 | 29542719 |
Autism spectrum disorder | 23.66 | 10.92 | 18 | 28895 | 2014 | 29543600 |
Anticholinergic syndrome | 22.97 | 10.92 | 13 | 28900 | 881 | 29544733 |
Electrocardiogram QRS complex prolonged | 22.92 | 10.92 | 24 | 28889 | 4086 | 29541528 |
Pyelocaliectasis | 22.90 | 10.92 | 14 | 28899 | 1095 | 29544519 |
Drug dependence | 22.82 | 10.92 | 58 | 28855 | 20923 | 29524691 |
Tachyphrenia | 22.22 | 10.92 | 14 | 28899 | 1155 | 29544459 |
Febrile bone marrow aplasia | 21.51 | 10.92 | 31 | 28882 | 7320 | 29538294 |
Myocardial infarction | 21.04 | 10.92 | 48 | 28865 | 110248 | 29435366 |
Respiratory depression | 20.95 | 10.92 | 43 | 28870 | 13480 | 29532134 |
Stereotypy | 20.86 | 10.92 | 11 | 28902 | 648 | 29544966 |
Tachycardia | 20.48 | 10.92 | 131 | 28782 | 72279 | 29473335 |
Rash | 20.08 | 10.92 | 278 | 28635 | 189541 | 29356073 |
Disease progression | 19.70 | 10.92 | 31 | 28882 | 81885 | 29463729 |
Mumps | 19.62 | 10.92 | 6 | 28907 | 81 | 29545533 |
Miosis | 19.50 | 10.92 | 31 | 28882 | 7978 | 29537636 |
Echolalia | 19.36 | 10.92 | 8 | 28905 | 269 | 29545345 |
Drug ineffective | 18.99 | 10.92 | 246 | 28667 | 362924 | 29182690 |
Mental disorder | 18.79 | 10.92 | 40 | 28873 | 12865 | 29532749 |
Bladder dilatation | 18.43 | 10.92 | 13 | 28900 | 1295 | 29544319 |
Dry skin | 18.07 | 10.92 | 57 | 28856 | 23250 | 29522364 |
Agitation | 17.84 | 10.92 | 98 | 28815 | 51206 | 29494408 |
Drug screen positive | 17.38 | 10.92 | 20 | 28893 | 3781 | 29541833 |
Fixed eruption | 17.06 | 10.92 | 12 | 28901 | 1190 | 29544424 |
Agoraphobia | 16.95 | 10.92 | 7 | 28906 | 235 | 29545379 |
Intentional product misuse | 16.94 | 10.92 | 73 | 28840 | 34588 | 29511026 |
Psychotic disorder | 16.92 | 10.92 | 51 | 28862 | 20303 | 29525311 |
Suicidal ideation | 16.88 | 10.92 | 73 | 28840 | 34643 | 29510971 |
Drug withdrawal syndrome | 16.81 | 10.92 | 47 | 28866 | 17937 | 29527677 |
Injection site reaction | 16.66 | 10.92 | 35 | 28878 | 11153 | 29534461 |
Infective pulmonary exacerbation of cystic fibrosis | 16.38 | 10.92 | 25 | 28888 | 6211 | 29539403 |
Disturbance in attention | 16.25 | 10.92 | 52 | 28861 | 21372 | 29524242 |
Eosinophilia | 16.10 | 10.92 | 53 | 28860 | 22108 | 29523506 |
Tremor | 16.08 | 10.92 | 125 | 28788 | 73413 | 29472201 |
Rash erythematous | 16.05 | 10.92 | 52 | 28861 | 21510 | 29524104 |
Serotonin syndrome | 15.62 | 10.92 | 45 | 28868 | 17467 | 29528147 |
Hypercapnic coma | 15.58 | 10.92 | 6 | 28907 | 167 | 29545447 |
Generalised oedema | 15.56 | 10.92 | 34 | 28879 | 11131 | 29534483 |
Administration related reaction | 15.46 | 10.92 | 5 | 28908 | 82 | 29545532 |
Diarrhoea infectious | 15.35 | 10.92 | 8 | 28905 | 460 | 29545154 |
Eczema | 14.81 | 10.92 | 38 | 28875 | 13788 | 29531826 |
Neurodevelopmental disorder | 14.67 | 10.92 | 7 | 28906 | 333 | 29545281 |
C-reactive protein increased | 14.66 | 10.92 | 13 | 28900 | 44250 | 29501364 |
Neonatal respiratory distress | 14.59 | 10.92 | 8 | 28905 | 510 | 29545104 |
Anaemia | 14.58 | 10.92 | 126 | 28787 | 200825 | 29344789 |
Pneumonia | 14.54 | 10.92 | 223 | 28690 | 319949 | 29225665 |
Thyroiditis acute | 14.31 | 10.92 | 5 | 28908 | 105 | 29545509 |
Prothrombin time ratio decreased | 14.30 | 10.92 | 7 | 28906 | 352 | 29545262 |
Acute generalised exanthematous pustulosis | 14.13 | 10.92 | 22 | 28891 | 5561 | 29540053 |
Speech disorder developmental | 14.11 | 10.92 | 13 | 28900 | 1894 | 29543720 |
Victim of crime | 14.05 | 10.92 | 7 | 28906 | 366 | 29545248 |
Throat tightness | 14.01 | 10.92 | 25 | 28888 | 7066 | 29538548 |
Rheumatoid arthritis | 13.93 | 10.92 | 7 | 28906 | 32145 | 29513469 |
Meningioma | 13.72 | 10.92 | 11 | 28902 | 1329 | 29544285 |
Sinus tachycardia | 13.71 | 10.92 | 39 | 28874 | 15030 | 29530584 |
Faecal vomiting | 13.62 | 10.92 | 7 | 28906 | 391 | 29545223 |
Victim of homicide | 13.60 | 10.92 | 5 | 28908 | 122 | 29545492 |
Cerebrovascular accident | 13.46 | 10.92 | 35 | 28878 | 76876 | 29468738 |
Diarrhoea | 13.37 | 10.92 | 237 | 28676 | 332461 | 29213153 |
Pupillary reflex impaired | 13.23 | 10.92 | 11 | 28902 | 1398 | 29544216 |
Mixed dementia | 12.86 | 10.92 | 6 | 28907 | 271 | 29545343 |
Neurosis | 12.86 | 10.92 | 5 | 28908 | 143 | 29545471 |
Acute respiratory distress syndrome | 12.53 | 10.92 | 50 | 28863 | 22885 | 29522729 |
Arthritis allergic | 12.43 | 10.92 | 3 | 28910 | 15 | 29545599 |
Suicide attempt | 12.42 | 10.92 | 66 | 28847 | 34044 | 29511570 |
Cerebral disorder | 12.02 | 10.92 | 13 | 28900 | 2295 | 29543319 |
Chronic spontaneous urticaria | 12.02 | 10.92 | 4 | 28909 | 72 | 29545542 |
Anion gap | 11.99 | 10.92 | 8 | 28905 | 728 | 29544886 |
Post-traumatic stress disorder | 11.89 | 10.92 | 11 | 28902 | 1611 | 29544003 |
Atrial fibrillation | 11.85 | 10.92 | 58 | 28855 | 105588 | 29440026 |
Cardiac failure congestive | 11.82 | 10.92 | 37 | 28876 | 76544 | 29469070 |
Injection site mass | 11.77 | 10.92 | 20 | 28893 | 5435 | 29540179 |
Aplastic anaemia | 11.77 | 10.92 | 24 | 28889 | 7486 | 29538128 |
Anxiety | 11.56 | 10.92 | 131 | 28782 | 85234 | 29460380 |
Pharyngeal dyskinesia | 11.46 | 10.92 | 3 | 28910 | 22 | 29545592 |
Alcohol withdrawal syndrome | 11.43 | 10.92 | 10 | 28903 | 1363 | 29544251 |
Aspirin-exacerbated respiratory disease | 11.28 | 10.92 | 6 | 28907 | 360 | 29545254 |
Drug diversion | 11.25 | 10.92 | 8 | 28905 | 807 | 29544807 |
Neuropathy peripheral | 11.18 | 10.92 | 34 | 28879 | 70993 | 29474621 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 1318.52 | 10.20 | 1442 | 71999 | 222972 | 64202319 |
Toxicity to various agents | 580.72 | 10.20 | 1277 | 72164 | 362236 | 64063055 |
Intentional overdose | 307.53 | 10.20 | 442 | 72999 | 89502 | 64335789 |
Drug abuse | 275.61 | 10.20 | 520 | 72921 | 131854 | 64293437 |
Urticaria | 248.38 | 10.20 | 530 | 72911 | 146787 | 64278504 |
Pruritus | 225.42 | 10.20 | 824 | 72617 | 311576 | 64113715 |
Respiratory arrest | 205.85 | 10.20 | 277 | 73164 | 52708 | 64372583 |
Poisoning | 205.01 | 10.20 | 182 | 73259 | 21697 | 64403594 |
Intentional self-injury | 198.62 | 10.20 | 203 | 73238 | 28841 | 64396450 |
Cardio-respiratory arrest | 185.73 | 10.20 | 371 | 73070 | 98022 | 64327269 |
Cardiac arrest | 123.39 | 10.20 | 421 | 73020 | 153643 | 64271648 |
Dermatitis atopic | 103.64 | 10.20 | 61 | 73380 | 3815 | 64421476 |
Anticholinergic syndrome | 101.57 | 10.20 | 53 | 73388 | 2616 | 64422675 |
Suicide attempt | 94.62 | 10.20 | 233 | 73208 | 70774 | 64354517 |
Drug reaction with eosinophilia and systemic symptoms | 94.62 | 10.20 | 198 | 73243 | 54019 | 64371272 |
Poisoning deliberate | 93.69 | 10.20 | 95 | 73346 | 13363 | 64411928 |
Somnolence | 90.11 | 10.20 | 464 | 72977 | 203181 | 64222110 |
Synovitis | 86.45 | 10.20 | 7 | 73434 | 99083 | 64326208 |
Joint swelling | 83.99 | 10.20 | 73 | 73368 | 215309 | 64209982 |
Rheumatoid arthritis | 82.48 | 10.20 | 42 | 73399 | 164252 | 64261039 |
Bradypnoea | 78.42 | 10.20 | 57 | 73384 | 5102 | 64420189 |
Chemical submission | 75.93 | 10.20 | 22 | 73419 | 206 | 64425085 |
Drug dependence | 75.65 | 10.20 | 136 | 73305 | 33176 | 64392115 |
Overdose | 73.66 | 10.20 | 368 | 73073 | 159198 | 64266093 |
Coma | 70.58 | 10.20 | 240 | 73201 | 87375 | 64337916 |
Suspected suicide | 65.62 | 10.20 | 64 | 73377 | 8590 | 64416701 |
Contraindicated product administered | 64.77 | 10.20 | 21 | 73420 | 107808 | 64317483 |
Burning mouth syndrome | 62.92 | 10.20 | 23 | 73418 | 471 | 64424820 |
Electrocardiogram QT prolonged | 60.83 | 10.20 | 214 | 73227 | 79234 | 64346057 |
Eczema | 60.79 | 10.20 | 116 | 73325 | 29604 | 64395687 |
Anxiety | 60.16 | 10.20 | 416 | 73025 | 202233 | 64223058 |
Chronic spontaneous urticaria | 55.21 | 10.20 | 21 | 73420 | 482 | 64424809 |
Skin plaque | 54.87 | 10.20 | 59 | 73382 | 8881 | 64416410 |
Treatment failure | 54.08 | 10.20 | 33 | 73408 | 116783 | 64308508 |
Pemphigus | 53.75 | 10.20 | 4 | 73437 | 60697 | 64364594 |
Pericarditis | 52.93 | 10.20 | 5 | 73436 | 62511 | 64362780 |
Drug intolerance | 52.54 | 10.20 | 83 | 73358 | 187909 | 64237382 |
Arthropathy | 50.87 | 10.20 | 38 | 73403 | 120929 | 64304362 |
Serotonin syndrome | 50.31 | 10.20 | 127 | 73314 | 39155 | 64386136 |
Alcoholism | 50.23 | 10.20 | 37 | 73404 | 3380 | 64421911 |
Urticaria thermal | 49.60 | 10.20 | 15 | 73426 | 165 | 64425126 |
Suicidal behaviour | 48.73 | 10.20 | 34 | 73407 | 2853 | 64422438 |
Intentional product misuse | 48.01 | 10.20 | 186 | 73255 | 72109 | 64353182 |
Glossodynia | 45.77 | 10.20 | 9 | 73432 | 64687 | 64360604 |
General physical health deterioration | 44.29 | 10.20 | 105 | 73336 | 204320 | 64220971 |
Systemic lupus erythematosus | 43.39 | 10.20 | 17 | 73424 | 77595 | 64347696 |
Asphyxia | 41.76 | 10.20 | 53 | 73388 | 9513 | 64415778 |
Therapeutic product effect decreased | 41.51 | 10.20 | 42 | 73399 | 115309 | 64309982 |
Parasomnia | 41.48 | 10.20 | 17 | 73424 | 478 | 64424813 |
Ureteric compression | 40.94 | 10.20 | 13 | 73428 | 170 | 64425121 |
Faecal vomiting | 40.86 | 10.20 | 21 | 73420 | 1004 | 64424287 |
Disturbance in attention | 40.83 | 10.20 | 121 | 73320 | 40953 | 64384338 |
Drug hypersensitivity | 40.75 | 10.20 | 432 | 73009 | 237383 | 64187908 |
Psoriasis | 40.13 | 10.20 | 175 | 73266 | 71528 | 64353763 |
Suicidal ideation | 40.02 | 10.20 | 166 | 73275 | 66376 | 64358915 |
Dermatitis exfoliative generalised | 39.79 | 10.20 | 41 | 73400 | 5875 | 64419416 |
Exposure via ingestion | 38.57 | 10.20 | 37 | 73404 | 4865 | 64420426 |
Hyperthermia | 38.56 | 10.20 | 66 | 73375 | 15484 | 64409807 |
Miosis | 37.88 | 10.20 | 60 | 73381 | 13206 | 64412085 |
Lower respiratory tract infection | 36.93 | 10.20 | 32 | 73409 | 94582 | 64330709 |
Anaemia | 36.88 | 10.20 | 266 | 73175 | 378414 | 64046877 |
Victim of chemical submission | 34.65 | 10.20 | 13 | 73428 | 287 | 64425004 |
Multiple drug therapy | 34.48 | 10.20 | 25 | 73416 | 2229 | 64423062 |
Scratch | 33.28 | 10.20 | 39 | 73402 | 6450 | 64418841 |
Hallucination, gustatory | 33.13 | 10.20 | 9 | 73432 | 65 | 64425226 |
Hepatic enzyme increased | 32.96 | 10.20 | 61 | 73380 | 129882 | 64295409 |
Agitation | 32.74 | 10.20 | 192 | 73249 | 88175 | 64337116 |
Wound | 32.18 | 10.20 | 24 | 73417 | 76453 | 64348838 |
Priapism | 31.30 | 10.20 | 30 | 73411 | 3940 | 64421351 |
Angioedema | 30.94 | 10.20 | 146 | 73295 | 61675 | 64363616 |
Pneumonia | 30.55 | 10.20 | 451 | 72990 | 559125 | 63866166 |
Rash maculo-papular | 30.41 | 10.20 | 120 | 73321 | 46906 | 64378385 |
Drug screen positive | 30.33 | 10.20 | 35 | 73406 | 5694 | 64419597 |
Helicobacter infection | 30.13 | 10.20 | 4 | 73437 | 38358 | 64386933 |
Pyelocaliectasis | 30.07 | 10.20 | 16 | 73425 | 822 | 64424469 |
Drug withdrawal syndrome | 29.98 | 10.20 | 91 | 73350 | 31200 | 64394091 |
Allergy test positive | 29.95 | 10.20 | 13 | 73428 | 423 | 64424868 |
Irritability | 29.87 | 10.20 | 101 | 73340 | 36645 | 64388646 |
Mastocytosis | 29.61 | 10.20 | 13 | 73428 | 435 | 64424856 |
Respiratory depression | 29.19 | 10.20 | 75 | 73366 | 23368 | 64401923 |
Insomnia | 28.72 | 10.20 | 348 | 73093 | 197488 | 64227803 |
Infusion related reaction | 28.54 | 10.20 | 94 | 73347 | 164373 | 64260918 |
Altered state of consciousness | 28.06 | 10.20 | 101 | 73340 | 37801 | 64387490 |
Abdominal discomfort | 27.17 | 10.20 | 111 | 73330 | 182211 | 64243080 |
Distributive shock | 26.88 | 10.20 | 20 | 73421 | 1855 | 64423436 |
Long QT syndrome | 26.54 | 10.20 | 31 | 73410 | 5108 | 64420183 |
Drug ineffective | 26.20 | 10.20 | 743 | 72698 | 839504 | 63585787 |
Personal relationship issue | 25.29 | 10.20 | 9 | 73432 | 170 | 64425121 |
Perfume sensitivity | 24.83 | 10.20 | 13 | 73428 | 646 | 64424645 |
Depression | 24.71 | 10.20 | 318 | 73123 | 182973 | 64242318 |
Psychotic symptom | 24.56 | 10.20 | 20 | 73421 | 2118 | 64423173 |
Urinary retention | 24.48 | 10.20 | 116 | 73325 | 49085 | 64376206 |
Maternal exposure during pregnancy | 24.32 | 10.20 | 45 | 73396 | 95839 | 64329452 |
Eosinophilia | 23.69 | 10.20 | 96 | 73345 | 37980 | 64387311 |
Dry skin | 23.57 | 10.20 | 118 | 73323 | 51043 | 64374248 |
Injection site reaction | 23.20 | 10.20 | 110 | 73331 | 46554 | 64378737 |
C-reactive protein increased | 22.80 | 10.20 | 46 | 73395 | 94863 | 64330428 |
Diet failure | 22.76 | 10.20 | 6 | 73435 | 38 | 64425253 |
Neuropathy peripheral | 22.65 | 10.20 | 64 | 73377 | 117461 | 64307830 |
Tachyphrenia | 22.50 | 10.20 | 18 | 73423 | 1858 | 64423433 |
Injection site mass | 22.28 | 10.20 | 56 | 73385 | 17214 | 64408077 |
Arthritis allergic | 21.98 | 10.20 | 5 | 73436 | 15 | 64425276 |
Febrile bone marrow aplasia | 21.88 | 10.20 | 43 | 73398 | 11212 | 64414079 |
Mixed liver injury | 21.79 | 10.20 | 29 | 73412 | 5452 | 64419839 |
Labile hypertension | 21.46 | 10.20 | 11 | 73430 | 523 | 64424768 |
Atrial fibrillation | 21.42 | 10.20 | 111 | 73330 | 170978 | 64254313 |
Accidental overdose | 21.19 | 10.20 | 85 | 73356 | 33472 | 64391819 |
Infection | 20.41 | 10.20 | 125 | 73316 | 184755 | 64240536 |
Fixed eruption | 20.30 | 10.20 | 18 | 73423 | 2141 | 64423150 |
Musculoskeletal stiffness | 20.29 | 10.20 | 72 | 73369 | 123134 | 64302157 |
Prothrombin time ratio decreased | 20.23 | 10.20 | 12 | 73429 | 761 | 64424530 |
Binge eating | 20.23 | 10.20 | 10 | 73431 | 440 | 64424851 |
Urticaria chronic | 20.21 | 10.20 | 10 | 73431 | 441 | 64424850 |
Neutropenia | 20.19 | 10.20 | 175 | 73266 | 239449 | 64185842 |
Panic attack | 20.13 | 10.20 | 61 | 73380 | 20892 | 64404399 |
Sensitivity to weather change | 20.05 | 10.20 | 31 | 73410 | 6683 | 64418608 |
Disease progression | 20.03 | 10.20 | 88 | 73353 | 141592 | 64283699 |
Impaired healing | 19.58 | 10.20 | 24 | 73417 | 60449 | 64364842 |
Tachycardia | 19.52 | 10.20 | 258 | 73183 | 149321 | 64275970 |
Feeling abnormal | 19.37 | 10.20 | 235 | 73206 | 133367 | 64291924 |
Drug resistance | 19.11 | 10.20 | 8 | 73433 | 35094 | 64390197 |
Diarrhoea | 19.09 | 10.20 | 653 | 72788 | 722051 | 63703240 |
Mydriasis | 19.08 | 10.20 | 49 | 73392 | 15263 | 64410028 |
Haematoma muscle | 18.99 | 10.20 | 16 | 73425 | 1777 | 64423514 |
Acute respiratory distress syndrome | 18.79 | 10.20 | 91 | 73350 | 38844 | 64386447 |
Plasma cell myeloma | 18.69 | 10.20 | 15 | 73426 | 46060 | 64379231 |
Withdrawal syndrome | 18.59 | 10.20 | 64 | 73377 | 23428 | 64401863 |
Postmortem blood drug level | 18.49 | 10.20 | 8 | 73433 | 258 | 64425033 |
Cerebral infarction | 18.43 | 10.20 | 12 | 73429 | 41032 | 64384259 |
Renal impairment | 18.40 | 10.20 | 85 | 73356 | 134932 | 64290359 |
Affect lability | 18.27 | 10.20 | 35 | 73406 | 8955 | 64416336 |
Pleural effusion | 18.26 | 10.20 | 78 | 73363 | 126481 | 64298810 |
Therapeutic product effect incomplete | 18.04 | 10.20 | 59 | 73382 | 103423 | 64321868 |
Toxic epidermal necrolysis | 18.03 | 10.20 | 87 | 73354 | 37079 | 64388212 |
Haemoglobin decreased | 18.01 | 10.20 | 139 | 73302 | 194924 | 64230367 |
Malignant neoplasm progression | 17.90 | 10.20 | 67 | 73374 | 112804 | 64312487 |
Victim of crime | 17.75 | 10.20 | 9 | 73432 | 418 | 64424873 |
Joint ankylosis | 17.71 | 10.20 | 11 | 73430 | 758 | 64424533 |
Pulmonary fibrosis | 17.62 | 10.20 | 6 | 73435 | 29872 | 64395419 |
Electrocardiogram QRS complex prolonged | 17.58 | 10.20 | 35 | 73406 | 9209 | 64416082 |
Thrombocytopenia | 17.31 | 10.20 | 167 | 73274 | 223634 | 64201657 |
Red blood cell sedimentation rate increased | 17.19 | 10.20 | 7 | 73434 | 31228 | 64394063 |
Abnormal sleep-related event | 17.15 | 10.20 | 11 | 73430 | 802 | 64424489 |
Nodular rash | 17.08 | 10.20 | 8 | 73433 | 312 | 64424979 |
Cold agglutinins positive | 17.05 | 10.20 | 5 | 73436 | 49 | 64425242 |
Haemorrhage | 16.97 | 10.20 | 41 | 73400 | 79310 | 64345981 |
Depressed level of consciousness | 16.88 | 10.20 | 154 | 73287 | 81282 | 64344009 |
International normalised ratio increased | 16.86 | 10.20 | 41 | 73400 | 79126 | 64346165 |
Exposure during pregnancy | 16.72 | 10.20 | 40 | 73401 | 77635 | 64347656 |
Product dose omission issue | 16.68 | 10.20 | 313 | 73128 | 194434 | 64230857 |
Non-cardiogenic pulmonary oedema | 16.66 | 10.20 | 13 | 73428 | 1295 | 64423996 |
Photosensitivity reaction | 16.62 | 10.20 | 52 | 73389 | 18121 | 64407170 |
Temperature intolerance | 16.61 | 10.20 | 32 | 73409 | 8223 | 64417068 |
Post-traumatic stress disorder | 16.34 | 10.20 | 22 | 73419 | 4183 | 64421108 |
Myocardial infarction | 16.34 | 10.20 | 116 | 73325 | 165705 | 64259586 |
Alopecia | 16.28 | 10.20 | 116 | 73325 | 165574 | 64259717 |
Aggression | 16.19 | 10.20 | 99 | 73342 | 46133 | 64379158 |
Skin lesion | 16.00 | 10.20 | 83 | 73358 | 36399 | 64388892 |
Poor feeding infant | 15.80 | 10.20 | 6 | 73435 | 137 | 64425154 |
Hypercapnic coma | 15.54 | 10.20 | 8 | 73433 | 384 | 64424907 |
Dyspnoea | 15.52 | 10.20 | 665 | 72776 | 718009 | 63707282 |
Blood creatinine increased | 15.40 | 10.20 | 91 | 73350 | 135691 | 64289600 |
Derailment | 15.37 | 10.20 | 5 | 73436 | 71 | 64425220 |
Gastrointestinal haemorrhage | 15.37 | 10.20 | 88 | 73353 | 132224 | 64293067 |
Haematoma | 15.35 | 10.20 | 18 | 73423 | 46232 | 64379059 |
Hyperleukocytosis | 15.30 | 10.20 | 15 | 73426 | 2025 | 64423266 |
Polymicrogyria | 15.26 | 10.20 | 3 | 73438 | 3 | 64425288 |
Pancreatitis | 15.15 | 10.20 | 118 | 73323 | 59489 | 64365802 |
Rash erythematous | 15.09 | 10.20 | 101 | 73340 | 48532 | 64376759 |
Dementia | 15.08 | 10.20 | 55 | 73386 | 20711 | 64404580 |
Cerebral disorder | 15.07 | 10.20 | 22 | 73419 | 4507 | 64420784 |
Lip erythema | 14.97 | 10.20 | 6 | 73435 | 159 | 64425132 |
Toxic skin eruption | 14.80 | 10.20 | 52 | 73389 | 19232 | 64406059 |
Cerebral haemorrhage | 14.79 | 10.20 | 22 | 73419 | 51068 | 64374223 |
Blood immunoglobulin E increased | 14.77 | 10.20 | 20 | 73421 | 3824 | 64421467 |
Off label use | 14.61 | 10.20 | 581 | 72860 | 632225 | 63793066 |
Muscle injury | 14.43 | 10.20 | 6 | 73435 | 26431 | 64398860 |
Tremor | 14.38 | 10.20 | 243 | 73198 | 147987 | 64277304 |
Face oedema | 14.28 | 10.20 | 61 | 73380 | 24700 | 64400591 |
Alpha 1 globulin increased | 14.28 | 10.20 | 5 | 73436 | 90 | 64425201 |
Wrong technique in device usage process | 14.25 | 10.20 | 17 | 73424 | 2865 | 64422426 |
Pancytopenia | 14.24 | 10.20 | 100 | 73341 | 143209 | 64282082 |
Clonus | 14.07 | 10.20 | 25 | 73416 | 6042 | 64419249 |
Cardiac failure congestive | 14.04 | 10.20 | 89 | 73352 | 130491 | 64294800 |
Substance abuse | 14.00 | 10.20 | 32 | 73409 | 9260 | 64416031 |
Lymphomatoid papulosis | 13.93 | 10.20 | 7 | 73434 | 319 | 64424972 |
Aplastic anaemia | 13.82 | 10.20 | 41 | 73400 | 13879 | 64411412 |
Injection site induration | 13.72 | 10.20 | 31 | 73410 | 8901 | 64416390 |
Peripheral circulatory failure | 13.72 | 10.20 | 9 | 73432 | 682 | 64424609 |
Pupillary reflex impaired | 13.37 | 10.20 | 17 | 73424 | 3056 | 64422235 |
Papule | 13.25 | 10.20 | 25 | 73416 | 6325 | 64418966 |
Restless arm syndrome | 13.23 | 10.20 | 4 | 73437 | 44 | 64425247 |
Tardive dyskinesia | 13.16 | 10.20 | 31 | 73410 | 9147 | 64416144 |
Infective pulmonary exacerbation of cystic fibrosis | 12.93 | 10.20 | 36 | 73405 | 11760 | 64413531 |
Mental disorder | 12.90 | 10.20 | 62 | 73379 | 26383 | 64398908 |
Bladder dilatation | 12.74 | 10.20 | 13 | 73428 | 1841 | 64423450 |
Administration related reaction | 12.71 | 10.20 | 5 | 73436 | 126 | 64425165 |
Cerebrovascular accident | 12.71 | 10.20 | 98 | 73343 | 137485 | 64287806 |
Acute myocardial infarction | 12.68 | 10.20 | 39 | 73402 | 69679 | 64355612 |
Anion gap | 12.67 | 10.20 | 13 | 73428 | 1854 | 64423437 |
Arthralgia | 12.49 | 10.20 | 396 | 73045 | 441864 | 63983427 |
Breast adenoma | 12.41 | 10.20 | 4 | 73437 | 55 | 64425236 |
Dyskinesia | 12.34 | 10.20 | 82 | 73359 | 39306 | 64385985 |
Mental status changes | 12.34 | 10.20 | 115 | 73326 | 61047 | 64364244 |
Initial insomnia | 12.29 | 10.20 | 23 | 73418 | 5781 | 64419510 |
Autonomic nervous system imbalance | 12.23 | 10.20 | 19 | 73422 | 4113 | 64421178 |
Sensation of blood flow | 12.16 | 10.20 | 4 | 73437 | 59 | 64425232 |
Transverse sinus thrombosis | 12.13 | 10.20 | 8 | 73433 | 612 | 64424679 |
Rash pruritic | 12.12 | 10.20 | 109 | 73332 | 57295 | 64367996 |
Parkinsonism | 12.12 | 10.20 | 40 | 73401 | 14333 | 64410958 |
Myelosuppression | 12.08 | 10.20 | 6 | 73435 | 23824 | 64401467 |
Skin exfoliation | 12.05 | 10.20 | 90 | 73351 | 44795 | 64380496 |
Hallucination, visual | 11.98 | 10.20 | 63 | 73378 | 27771 | 64397520 |
Sensory integrative dysfunction | 11.98 | 10.20 | 3 | 73438 | 15 | 64425276 |
Apallic syndrome | 11.95 | 10.20 | 9 | 73432 | 850 | 64424441 |
Arthritis | 11.87 | 10.20 | 52 | 73389 | 83762 | 64341529 |
Vaginal lesion | 11.87 | 10.20 | 5 | 73436 | 151 | 64425140 |
Vasculitis | 11.83 | 10.20 | 3 | 73438 | 18092 | 64407199 |
Alpha 2 globulin increased | 11.74 | 10.20 | 5 | 73436 | 155 | 64425136 |
Hallucination, olfactory | 11.74 | 10.20 | 7 | 73434 | 448 | 64424843 |
Mixed dementia | 11.73 | 10.20 | 6 | 73435 | 284 | 64425007 |
Osteonecrosis of jaw | 11.67 | 10.20 | 17 | 73424 | 39808 | 64385483 |
Steal syndrome | 11.67 | 10.20 | 3 | 73438 | 17 | 64425274 |
Dermatitis | 11.65 | 10.20 | 46 | 73395 | 17983 | 64407308 |
Multiple fractures | 11.65 | 10.20 | 23 | 73418 | 6017 | 64419274 |
Administration site erythema | 11.62 | 10.20 | 5 | 73436 | 159 | 64425132 |
Emotional disorder of childhood | 11.52 | 10.20 | 3 | 73438 | 18 | 64425273 |
Superior mesenteric artery syndrome | 11.48 | 10.20 | 5 | 73436 | 164 | 64425127 |
Wound secretion | 11.42 | 10.20 | 21 | 73420 | 5211 | 64420080 |
Burnout syndrome | 11.39 | 10.20 | 6 | 73435 | 302 | 64424989 |
Victim of homicide | 11.26 | 10.20 | 5 | 73436 | 172 | 64425119 |
Retrograde amnesia | 11.15 | 10.20 | 7 | 73434 | 492 | 64424799 |
Iron deficiency | 11.13 | 10.20 | 25 | 73416 | 7152 | 64418139 |
Clostridium difficile infection | 11.03 | 10.20 | 15 | 73426 | 36148 | 64389143 |
Erythema | 11.03 | 10.20 | 285 | 73156 | 186785 | 64238506 |
Electric shock sensation | 10.90 | 10.20 | 6 | 73435 | 330 | 64424961 |
Pharyngeal dyskinesia | 10.89 | 10.20 | 3 | 73438 | 23 | 64425268 |
Leukopenia | 10.88 | 10.20 | 69 | 73372 | 101173 | 64324118 |
White blood cell count decreased | 10.88 | 10.20 | 121 | 73320 | 157716 | 64267575 |
Acute generalised exanthematous pustulosis | 10.86 | 10.20 | 38 | 73403 | 14020 | 64411271 |
Adenoidectomy | 10.85 | 10.20 | 4 | 73437 | 84 | 64425207 |
Thyroiditis acute | 10.77 | 10.20 | 5 | 73436 | 191 | 64425100 |
Knee arthroplasty | 10.69 | 10.20 | 9 | 73432 | 26990 | 64398301 |
Postural orthostatic tachycardia syndrome | 10.69 | 10.20 | 7 | 73434 | 529 | 64424762 |
Emotional distress | 10.68 | 10.20 | 74 | 73367 | 35964 | 64389327 |
Fatigue | 10.66 | 10.20 | 722 | 72719 | 748008 | 63677283 |
Diabetic ketoacidosis | 10.58 | 10.20 | 11 | 73430 | 29834 | 64395457 |
Tonsillar hypertrophy | 10.58 | 10.20 | 10 | 73431 | 1291 | 64424000 |
Agoraphobia | 10.56 | 10.20 | 7 | 73434 | 540 | 64424751 |
Cardiac failure | 10.56 | 10.20 | 98 | 73343 | 132275 | 64293016 |
Dysuria | 10.54 | 10.20 | 83 | 73358 | 41974 | 64383317 |
Mood altered | 10.51 | 10.20 | 41 | 73400 | 15938 | 64409353 |
Sinusitis | 10.40 | 10.20 | 111 | 73330 | 145817 | 64279474 |
Pain of skin | 10.33 | 10.20 | 29 | 73412 | 9518 | 64415773 |
Interstitial lung disease | 10.30 | 10.20 | 67 | 73374 | 97665 | 64327626 |
Liver function test abnormal | 10.26 | 10.20 | 34 | 73407 | 59367 | 64365924 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Eyelid haemangioma | 20.86 | 17.91 | 3 | 6 | 9 | 84660 |
Source | Code | Description |
---|---|---|
ATC | N05BB01 | NERVOUS SYSTEM PSYCHOLEPTICS ANXIOLYTICS Diphenylmethane derivatives |
ATC | N05BB51 | NERVOUS SYSTEM PSYCHOLEPTICS ANXIOLYTICS Diphenylmethane derivatives |
FDA MoA | N0000000207 | Histamine Receptor Antagonists |
MeSH PA | D000982 | Antipruritics |
MeSH PA | D003879 | Dermatologic Agents |
MeSH PA | D018494 | Histamine Agents |
MeSH PA | D006633 | Histamine Antagonists |
MeSH PA | D006634 | Histamine H1 Antagonists |
MeSH PA | D018377 | Neurotransmitter Agents |
CHEBI has role | CHEBI:35474 | anti-anxiety agents |
CHEBI has role | CHEBI:37955 | H1 receptor antagonists |
CHEBI has role | CHEBI:50177 | dermatologic agent |
CHEBI has role | CHEBI:59683 | antipruritic drugs |
CHEBI has role | CHEBI:149553 | anticoronaviral drug |
FDA EPC | N0000175750 | Antihistamine |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Dermatographic urticaria | indication | 7632005 | DOID:743 |
Atopic dermatitis | indication | 24079001 | DOID:3310 |
Allergic rhinitis | indication | 61582004 | |
Nasal discharge | indication | 64531003 | |
Urticaria | indication | 126485001 | |
Itching of skin | indication | 418363000 | |
Allergic conjunctivitis | indication | 473460002 | DOID:11204 |
Severe Pruritus | off-label use | ||
Tachyarrhythmia | contraindication | 6285003 | |
Alcoholism | contraindication | 7200002 | |
Peptic ulcer | contraindication | 13200003 | DOID:750 |
Pulmonary edema | contraindication | 19242006 | DOID:11396 |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Shock | contraindication | 27942005 | |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Acute hepatitis | contraindication | 37871000 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Hypothyroidism | contraindication | 40930008 | DOID:1459 |
Third trimester pregnancy | contraindication | 41587001 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Chronic heart failure | contraindication | 48447003 | |
Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
Multiple organ failure | contraindication | 57653000 | |
Psychotic disorder | contraindication | 69322001 | |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Chronic idiopathic constipation | contraindication | 82934008 | |
Cor pulmonale | contraindication | 83291003 | DOID:8515 |
Open-angle glaucoma | contraindication | 84494001 | DOID:1067 |
Seizure disorder | contraindication | 128613002 | |
Cystic fibrosis | contraindication | 190905008 | DOID:1485 |
Angina pectoris | contraindication | 194828000 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Bladder outflow obstruction | contraindication | 236645006 | |
Sepsis syndrome | contraindication | 238150007 | |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Retention of urine | contraindication | 267064002 | |
Continuous fever | contraindication | 271751000 | |
Smoking cessation assistance | contraindication | 384742004 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Chronic myocardial ischemia | contraindication | 413844008 | DOID:3393 |
Disorder of coronary artery | contraindication | 414024009 | |
Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
Smokes tobacco daily | contraindication | 449868002 | |
Severe Hypoxemia | contraindication | ||
Theophylline Toxicity | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 7.53 | Basic |
pKa2 | 3.53 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Histamine H1 receptor | GPCR | ANTAGONIST | Ki | 8.70 | WOMBAT-PK | CHEMBL | |||
D(2) dopamine receptor | GPCR | Ki | 6.42 | CHEMBL | |||||
5-hydroxytryptamine receptor 2A | GPCR | Ki | 7.30 | CHEMBL | |||||
Cytochrome P450 2D6 | Enzyme | Ki | 5.41 | WOMBAT-PK | |||||
Envelope glycoprotein gp160 | Viral envelope protein | IC50 | 5.20 | CHEMBL | |||||
Envelope glycoprotein gp160 [Cleaved into: Surface protein gp120 | Unclassified | IC50 | 5.20 | CHEMBL |
ID | Source |
---|---|
4019782 | VUID |
N0000147873 | NUI |
D00672 | KEGG_DRUG |
4017874 | VANDF |
4017875 | VANDF |
4019782 | VANDF |
C0020404 | UMLSCUI |
CHEBI:5818 | CHEBI |
CHEMBL1201007 | ChEMBL_ID |
CHEMBL896 | ChEMBL_ID |
CHEMBL3186993 | ChEMBL_ID |
CHEMBL1200467 | ChEMBL_ID |
DB00557 | DRUGBANK_ID |
D006919 | MESH_DESCRIPTOR_UI |
3658 | PUBCHEM_CID |
7199 | IUPHAR_LIGAND_ID |
599 | INN_ID |
2192-20-3 | SECONDARY_CAS_RN |
30S50YM8OG | UNII |
154987 | RXNORM |
4857 | MMSL |
4858 | MMSL |
4859 | MMSL |
6478 | MMSL |
7094 | MMSL |
d00907 | MMSL |
001451 | NDDF |
001452 | NDDF |
001453 | NDDF |
372856003 | SNOMEDCT_US |
80165005 | SNOMEDCT_US |
83933007 | SNOMEDCT_US |
83945003 | SNOMEDCT_US |
10246-75-0 | SECONDARY_CAS_RN |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Vistaril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-5410 | CAPSULE | 25 mg | ORAL | NDA | 15 sections |
Vistaril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-5420 | CAPSULE | 50 mg | ORAL | NDA | 15 sections |
Vistaril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-5440 | SUSPENSION | 25 mg | ORAL | NDA | 15 sections |
Hydroxyzine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5060 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 13 sections |
Hydroxyzine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5060 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 13 sections |
Hydroxyzine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5061 | TABLET, FILM COATED | 25 mg | ORAL | ANDA | 13 sections |
Hydroxyzine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5061 | TABLET, FILM COATED | 25 mg | ORAL | ANDA | 13 sections |
Hydroxyzine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5062 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 13 sections |
Hydroxyzine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5062 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 13 sections |
Hydroxyzine Pamoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1670 | CAPSULE | 25 mg | ORAL | ANDA | 13 sections |
Hydroxyzine Pamoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1671 | CAPSULE | 50 mg | ORAL | ANDA | 13 sections |
Hydroxyzine Pamoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1803 | CAPSULE | 25 mg | ORAL | ANDA | 13 sections |
Hydroxyzine Pamoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1804 | CAPSULE | 50 mg | ORAL | ANDA | 13 sections |
Hydroxyzine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-4822 | SYRUP | 10 mg | ORAL | ANDA | 14 sections |
Hydroxyzine Pamoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0613 | CAPSULE | 25 mg | ORAL | ANDA | 14 sections |
Hydroxyzine Pamoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0613 | CAPSULE | 25 mg | ORAL | ANDA | 14 sections |
hydroxyzine pamoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0615 | CAPSULE | 50 mg | ORAL | ANDA | 14 sections |
hydroxyzine pamoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0615 | CAPSULE | 50 mg | ORAL | ANDA | 14 sections |
hydroxyzine pamoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0674 | CAPSULE | 25 mg | ORAL | ANDA | 14 sections |
hydroxyzine pamoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0674 | CAPSULE | 25 mg | ORAL | ANDA | 14 sections |
Hydroxyzine pamoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0676 | CAPSULE | 50 mg | ORAL | ANDA | 14 sections |
Hydroxyzine pamoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0676 | CAPSULE | 50 mg | ORAL | ANDA | 14 sections |
Hydroxyzine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9877 | INJECTION, SOLUTION | 50 mg | INTRAMUSCULAR | ANDA | 9 sections |
Hydroxyzine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9878 | INJECTION, SOLUTION | 50 mg | INTRAMUSCULAR | ANDA | 9 sections |
Hydroxyzine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0440-1617 | TABLET, FILM COATED | 25 mg | ORAL | ANDA | 11 sections |
Hydroxyzine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0517-4201 | INJECTION, SOLUTION | 25 mg | INTRAMUSCULAR | ANDA | 11 sections |
Hydroxyzine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0517-5601 | INJECTION, SOLUTION | 50 mg | INTRAMUSCULAR | ANDA | 11 sections |
Hydroxyzine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0517-5602 | INJECTION, SOLUTION | 50 mg | INTRAMUSCULAR | ANDA | 11 sections |
Hydroxyzine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0517-5610 | INJECTION, SOLUTION | 50 mg | INTRAMUSCULAR | ANDA | 11 sections |
Hydroxyzine Pamoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0555-0302 | CAPSULE | 50 mg | ORAL | ANDA | 13 sections |