hydroxychloroquine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
quinoline derivatives 1395 118-42-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hydroxychloroquine
  • hydroxychloroquine sulfate
  • oxichloroquine
  • oxychlorochin
  • oxychloroquine
A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970). In March 2020, FDA issued an emergency use authorization (EUA) for hydroxychloroquine and chloroquine in the treatment of COVID-10. EUA was revoked in June 2020. Data from various published randomized, controlled clinical trials and retrospective, cohort studies have not substantiated initial reports of efficacy of 4-aminoquinoline antimalarials for treatment of COVID-19.
  • Molecular weight: 335.88
  • Formula: C18H26ClN3O
  • CLOGP: 4.12
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 48.39
  • ALOGS: -4.11
  • ROTB: 9
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.52 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 20 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 27 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 29.77 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 74 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 700 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 11 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.57 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 850 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
April 18, 1955 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 6594.49 11.71 20444 477562 1024321 61966695
Drug intolerance 5003.29 11.71 8788 489218 299873 62691143
Contraindicated product administered 3668.80 11.71 6311 491695 211337 62779679
Joint swelling 3288.15 11.71 7648 490358 320018 62670998
Rheumatoid arthritis 3228.52 11.71 6522 491484 247297 62743719
Synovitis 3190.46 11.71 5452 492554 181466 62809550
Treatment failure 2875.72 11.71 5399 492607 193644 62797372
Systemic lupus erythematosus 2310.15 11.71 5073 492933 203845 62787171
Therapeutic product effect decreased 2236.18 11.71 4779 493227 188408 62802608
Arthropathy 2218.00 11.71 5358 492648 229434 62761582
Pemphigus 1961.12 11.71 4400 493606 179326 62811690
Abdominal discomfort 1696.09 11.71 5948 492058 314937 62676079
Glossodynia 1616.17 11.71 4015 493991 174861 62816155
Hand deformity 1597.05 11.71 3725 494281 155732 62835284
Alopecia 1515.13 11.71 5936 492070 331600 62659416
Death 1469.39 11.71 551 497455 373830 62617186
Swelling 1458.89 11.71 5110 492896 270268 62720748
Pain 1308.94 11.71 10091 487915 730537 62260479
Arthralgia 1290.11 11.71 8248 489758 561462 62429554
Anti-cyclic citrullinated peptide antibody positive 1046.88 11.71 2607 495399 113605 62877411
Hepatic enzyme increased 1039.65 11.71 3719 494287 198609 62792407
C-reactive protein abnormal 1022.76 11.71 1518 496488 44578 62946438
Rheumatoid factor positive 1006.78 11.71 2116 495890 82290 62908726
Musculoskeletal stiffness 1002.35 11.71 3456 494550 181162 62809854
Wound 985.63 11.71 3168 494838 160095 62830921
Acute kidney injury 928.38 11.71 453 497553 262962 62728054
Pericarditis 849.77 11.71 2614 495392 128965 62862051
Completed suicide 822.51 11.71 91 497915 145582 62845434
Red blood cell sedimentation rate abnormal 822.03 11.71 891 497115 18891 62972125
Constipation 816.87 11.71 371 497635 224572 62766444
Anaemia 767.45 11.71 703 497303 292727 62698289
Peripheral swelling 766.03 11.71 4108 493898 261834 62729182
Therapeutic product effect incomplete 745.60 11.71 2417 495589 122639 62868377
Hypersensitivity 739.14 11.71 4364 493642 288321 62702695
Discomfort 730.42 11.71 2921 495085 164453 62826563
Condition aggravated 677.38 11.71 5428 492578 396789 62594227
Off label use 668.74 11.71 8146 489860 666316 62324700
Product use issue 666.69 11.71 3453 494553 217067 62773949
Hypotension 664.32 11.71 695 497311 271909 62719107
Dehydration 664.26 11.71 264 497742 173090 62817926
Red blood cell sedimentation rate increased 646.59 11.71 1204 496802 42778 62948238
Rash 615.64 11.71 6910 491096 553961 62437055
Drug hypersensitivity 610.52 11.71 4349 493657 306338 62684678
Febrile neutropenia 595.87 11.71 105 497901 118344 62872672
C-reactive protein increased 589.40 11.71 1858 496148 92849 62898167
Infusion related reaction 570.68 11.71 3584 494422 241937 62749079
Maternal exposure during pregnancy 561.94 11.71 3292 494714 216770 62774246
Hyponatraemia 554.65 11.71 103 497903 111797 62879219
Helicobacter infection 547.13 11.71 1787 496219 90998 62900018
Gastrointestinal disorder 546.55 11.71 2258 495748 128981 62862035
Malignant neoplasm progression 541.58 11.71 24 497982 82097 62908919
Duodenal ulcer perforation 539.07 11.71 1707 496299 85502 62905514
Loss of personal independence in daily activities 536.61 11.71 1832 496174 95458 62895558
Muscle injury 518.07 11.71 1398 496608 63947 62927069
Folliculitis 507.77 11.71 1454 496552 68863 62922153
Tremor 505.49 11.71 202 497804 132037 62858979
Infection 502.07 11.71 3296 494710 225877 62765139
Toxicity to various agents 491.76 11.71 736 497270 246514 62744502
Seizure 490.24 11.71 213 497793 132421 62858595
Psoriatic arthropathy 484.39 11.71 1700 496306 89820 62901196
Somnolence 463.29 11.71 431 497575 178254 62812762
Ill-defined disorder 456.52 11.71 1546 496460 80209 62910807
Irritable bowel syndrome 451.04 11.71 1548 496458 80864 62910152
Drug interaction 443.18 11.71 695 497311 228436 62762580
Product dose omission issue 441.64 11.71 723 497283 233590 62757426
Impaired healing 431.30 11.71 1770 496236 100772 62890244
Lower respiratory tract infection 429.73 11.71 2115 495891 130192 62860824
Drug abuse 422.92 11.71 40 497966 72478 62918538
Dyspnoea 413.58 11.71 3267 494739 658046 62332970
Fall 404.79 11.71 1644 496362 390690 62600326
Atrial fibrillation 386.14 11.71 217 497789 116419 62874597
Anxiety 378.34 11.71 706 497300 216835 62774181
Thrombocytopenia 377.36 11.71 377 497629 150780 62840236
Sleep disorder due to general medical condition, insomnia type 374.26 11.71 1077 496929 51140 62939876
Retinal toxicity 370.65 11.71 187 497819 1088 62989928
Neutropenia 369.54 11.71 499 497507 174506 62816510
Inflammation 365.77 11.71 1445 496561 80828 62910188
Blister 361.25 11.71 1988 496018 127826 62863190
Renal failure 358.74 11.71 241 497765 117411 62873605
Bradycardia 357.31 11.71 70 497936 73157 62917859
Disease progression 350.08 11.71 270 497736 122488 62868528
Depressed level of consciousness 349.68 11.71 39 497967 62039 62928977
Mobility decreased 348.28 11.71 1872 496134 119287 62871729
Knee arthroplasty 337.56 11.71 1064 496942 53142 62937874
Tachycardia 330.47 11.71 265 497741 117891 62873125
Pulmonary embolism 329.74 11.71 259 497747 116425 62874591
Overdose 325.75 11.71 255 497751 114823 62876193
Dizziness 321.49 11.71 2015 495991 427910 62563106
Blood iron abnormal 319.90 11.71 256 497750 3620 62987396
Balance disorder 319.22 11.71 131 497875 84291 62906725
Urinary tract infection 316.91 11.71 1042 496964 263642 62727374
Multiple sclerosis relapse 304.46 11.71 19 497987 48459 62942557
Gastrointestinal haemorrhage 303.65 11.71 128 497878 81048 62909968
Rheumatoid nodule 301.55 11.71 508 497498 16647 62974369
Coma 298.74 11.71 69 497937 64295 62926721
Platelet count decreased 296.28 11.71 284 497722 115838 62875178
Neutrophil count decreased 287.99 11.71 48 497958 56358 62934658
Hip arthroplasty 285.51 11.71 923 497083 46723 62944293
Cardio-respiratory arrest 280.84 11.71 63 497943 59896 62931120
Cerebrovascular accident 279.34 11.71 261 497745 107763 62883253
Cognitive disorder 277.31 11.71 51 497955 55764 62935252
Sepsis 275.89 11.71 486 497520 152637 62838379
Hyperkalaemia 272.61 11.71 48 497958 54155 62936861
Arthritis 271.15 11.71 1696 496310 114225 62876791
Musculoskeletal disorder 268.84 11.71 537 497469 20107 62970909
Agitation 267.69 11.71 69 497937 59688 62931328
White blood cell count decreased 266.80 11.71 424 497582 138680 62852336
Osteoarthritis 264.40 11.71 1459 496547 93884 62897132
Fibromyalgia 264.10 11.71 1290 496716 79130 62911886
Pulmonary fibrosis 260.43 11.71 795 497211 39014 62952002
Abdominal pain 252.72 11.71 1313 496693 292143 62698873
Hyperhidrosis 252.23 11.71 284 497722 107552 62883464
Diarrhoea 250.18 11.71 4029 493977 711337 62279679
Intentional overdose 249.67 11.71 135 497871 74017 62916999
Rheumatic fever 246.51 11.71 822 497184 42289 62948727
Hallucination 246.12 11.71 63 497943 54754 62936262
Cardiac arrest 244.74 11.71 219 497787 92326 62898690
Suicide attempt 244.51 11.71 86 497920 60832 62930184
Retinopathy 242.61 11.71 199 497807 2920 62988096
Neoplasm progression 235.77 11.71 12 497994 36416 62954600
Blood glucose increased 231.48 11.71 190 497816 83566 62907450
Haemoglobin decreased 230.65 11.71 498 497508 144987 62846029
Impaired work ability 229.28 11.71 456 497550 17019 62973997
Respiratory failure 227.76 11.71 278 497728 101580 62889436
Syncope 227.74 11.71 355 497651 117030 62873986
Joint range of motion decreased 227.65 11.71 664 497342 31764 62959252
Oedema peripheral 226.73 11.71 746 497260 188765 62802251
Sedation 224.70 11.71 22 497984 38787 62952229
Epistaxis 224.30 11.71 147 497859 72578 62918438
Lactic acidosis 223.53 11.71 21 497985 38266 62952750
Asthenia 223.52 11.71 1929 496077 381675 62609341
Sinusitis 220.94 11.71 2733 495273 223920 62767096
Rhabdomyolysis 220.85 11.71 39 497967 43912 62947104
Cardiac failure 220.47 11.71 224 497782 88918 62902098
Metabolic acidosis 220.03 11.71 43 497963 45026 62945990
Blood cholesterol increased 218.14 11.71 1373 496633 92659 62898357
Bone erosion 217.81 11.71 450 497556 17267 62973749
Grip strength decreased 217.43 11.71 516 497490 21771 62969245
Musculoskeletal pain 216.32 11.71 1351 496655 90926 62900090
Swollen joint count increased 214.69 11.71 697 497309 35357 62955659
Dysphagia 213.00 11.71 228 497778 88357 62902659
Device expulsion 212.55 11.71 16 497990 34906 62956110
Muscle spasms 210.94 11.71 581 497425 155569 62835447
Deformity 208.03 11.71 348 497658 11336 62979680
Disturbance in attention 207.65 11.71 27 497979 38162 62952854
Chest discomfort 201.71 11.71 345 497661 109624 62881392
Neuropathy peripheral 200.89 11.71 365 497641 113302 62877714
Cardiac failure congestive 198.62 11.71 260 497746 92173 62898843
International normalised ratio increased 194.26 11.71 61 497945 46364 62944652
Stomatitis 193.60 11.71 1798 496208 136927 62854089
Wrong technique in product usage process 192.26 11.71 126 497880 62214 62928802
Feeling abnormal 190.25 11.71 566 497440 147826 62843190
Decreased appetite 190.21 11.71 1171 496835 249881 62741135
Deep vein thrombosis 189.16 11.71 227 497779 83573 62907443
Intentional product use issue 188.85 11.71 1678 496328 126214 62864802
Drug tolerance decreased 188.60 11.71 421 497585 17052 62973964
Hypoxia 184.19 11.71 121 497885 59671 62931345
Serotonin syndrome 183.89 11.71 10 497996 28672 62962344
Bone pain 183.18 11.71 100 497906 54541 62936475
Cough 179.93 11.71 1451 496555 291292 62699724
Vision blurred 179.24 11.71 277 497729 91647 62899369
Tenosynovitis 178.61 11.71 358 497648 13437 62977579
Disability 178.13 11.71 424 497582 17923 62973093
Plasma cell myeloma 177.94 11.71 33 497973 35872 62955144
Paraesthesia 174.81 11.71 637 497369 156329 62834687
Hypoglycaemia 173.87 11.71 130 497876 59935 62931081
Pancytopenia 170.62 11.71 312 497694 96621 62894395
Chest pain 168.44 11.71 998 497008 214961 62776055
Blood parathyroid hormone decreased 168.19 11.71 287 497719 9504 62981512
Nasopharyngitis 167.95 11.71 2865 495141 251392 62739624
Palpitations 167.35 11.71 400 497606 112370 62878646
Myalgia 166.91 11.71 589 497417 145940 62845076
Respiratory arrest 166.15 11.71 28 497978 32617 62958399
Granuloma skin 166.10 11.71 263 497743 8174 62982842
Blood pressure decreased 165.83 11.71 159 497847 64863 62926153
Pleural effusion 164.97 11.71 299 497707 92911 62898105
Encephalopathy 164.74 11.71 49 497957 38571 62952445
Liver injury 164.30 11.71 921 497085 59599 62931417
Joint stiffness 163.65 11.71 707 497299 41162 62949854
Panniculitis 162.67 11.71 308 497698 11077 62979939
Deafness transitory 162.33 11.71 130 497876 1840 62989176
Blood calcium decreased 161.32 11.71 12 497994 26439 62964577
Therapeutic response decreased 159.61 11.71 925 497081 60600 62930416
Dyskinesia 159.48 11.71 29 497977 31973 62959043
Blood bilirubin increased 156.83 11.71 48 497958 37092 62953924
Rectal haemorrhage 154.06 11.71 97 497909 48933 62942083
Hyperglycaemia 153.39 11.71 68 497938 41799 62949217
Adverse event 152.64 11.71 980 497026 66579 62924437
Pneumonia aspiration 152.56 11.71 41 497965 34499 62956517
Melaena 152.44 11.71 27 497979 30338 62960678
Fluid retention 152.16 11.71 146 497860 59540 62931476
Unresponsive to stimuli 151.54 11.71 39 497967 33777 62957239
Pneumonia 151.12 11.71 2597 495409 454170 62536846
Palmar-plantar erythrodysaesthesia syndrome 150.81 11.71 7 497999 23008 62968008
Maculopathy 150.66 11.71 132 497874 2130 62988886
Nausea 150.61 11.71 5341 492665 849130 62141886
Colitis 149.75 11.71 98 497908 48430 62942586
Depression 149.55 11.71 915 497091 195577 62795439
Disorientation 149.46 11.71 61 497945 39391 62951625
Lupus nephritis 148.95 11.71 145 497861 2694 62988322
Sopor 147.68 11.71 6 498000 22158 62968858
Suicidal ideation 147.45 11.71 163 497843 62258 62928758
Vomiting 146.69 11.71 3309 494697 556308 62434708
Dysarthria 146.35 11.71 76 497930 42635 62948381
Hypokalaemia 144.07 11.71 381 497625 103423 62887593
Pulmonary oedema 143.68 11.71 131 497875 54742 62936274
Drug withdrawal syndrome 143.66 11.71 21 497985 27173 62963843
Restlessness 141.89 11.71 29 497977 29424 62961592
Dysgeusia 141.89 11.71 96 497910 46614 62944402
Irritability 141.17 11.71 37 497969 31657 62959359
Multiple organ dysfunction syndrome 139.86 11.71 143 497863 56609 62934407
Haemorrhage 139.09 11.71 164 497842 60858 62930158
Hypomagnesaemia 139.05 11.71 28 497978 28709 62962307
Cerebral haemorrhage 138.54 11.71 35 497971 30694 62960322
Fatigue 137.35 11.71 8383 489623 879645 62111371
Vertigo 136.45 11.71 161 497845 59726 62931290
Chills 136.42 11.71 445 497561 112933 62878083
Pulmonary toxicity 135.35 11.71 256 497750 9199 62981817
Cholelithiasis 135.14 11.71 89 497917 43836 62947180
Haematochezia 134.14 11.71 133 497873 53411 62937605
Shoulder arthroplasty 133.62 11.71 161 497845 3841 62987175
Joint effusion 131.13 11.71 361 497645 16699 62974317
Lethargy 130.38 11.71 148 497858 55859 62935157
Accidental overdose 130.36 11.71 15 497991 23294 62967722
Metastases to bone 129.73 11.71 9 497997 21010 62970006
Hepatic failure 128.92 11.71 59 497947 35597 62955419
Pyrexia 128.90 11.71 2762 495244 467716 62523300
Joint destruction 128.79 11.71 199 497807 6053 62984963
Mental status changes 127.68 11.71 76 497930 39523 62951493
Gastrooesophageal reflux disease 127.50 11.71 358 497648 95281 62895735
Dry skin 127.41 11.71 155 497851 56732 62934284
Hepatic function abnormal 125.92 11.71 67 497939 37075 62953941
Flushing 125.72 11.71 249 497757 74838 62916178
Polyarthritis 125.06 11.71 258 497748 9888 62981128
Myocardial infarction 124.43 11.71 386 497620 99507 62891509
Type 2 diabetes mellitus 123.15 11.71 891 497115 62977 62928039
Urinary retention 122.92 11.71 42 497964 30259 62960757
Finger deformity 122.60 11.71 219 497787 7526 62983490
Osteonecrosis of jaw 122.58 11.71 61 497945 35062 62955954
Emotional distress 122.21 11.71 51 497955 32498 62958518
Abnormal behaviour 121.82 11.71 13 497993 21413 62969603
Generalised tonic-clonic seizure 121.62 11.71 38 497968 28978 62962038
Renal impairment 120.56 11.71 327 497679 88028 62902988
Full blood count decreased 120.54 11.71 28 497978 25996 62965020
Hospitalisation 119.04 11.71 311 497695 84770 62906246
Asthma 117.51 11.71 557 497449 127004 62864012
Aphasia 117.16 11.71 56 497950 32944 62958072
Abdominal distension 117.11 11.71 322 497684 86293 62904723
Mucosal inflammation 117.06 11.71 117 497889 46811 62944205
Product quality issue 116.81 11.71 68 497938 35797 62955219
Intentional self-injury 116.30 11.71 29 497977 25658 62965358
Adverse drug reaction 115.61 11.71 1042 496964 78672 62912344
Device dislocation 114.50 11.71 30 497976 25675 62965341
Jaundice 114.48 11.71 43 497963 29208 62961808
Metastases to liver 114.45 11.71 23 497983 23616 62967400
Blood alkaline phosphatase increased 114.38 11.71 101 497905 42866 62948150
Ascites 114.24 11.71 91 497915 40637 62950379
Haematoma 112.02 11.71 67 497939 34753 62956263
Intentional product misuse 111.77 11.71 191 497815 60726 62930290
Erythema 111.63 11.71 863 497143 174888 62816128
Pallor 111.43 11.71 50 497956 30518 62960498
Liver function test increased 111.02 11.71 531 497475 32280 62958736
Swollen tongue 110.50 11.71 68 497938 34732 62956284
Elbow deformity 110.23 11.71 93 497913 1422 62989594
Respiratory distress 109.68 11.71 65 497941 33886 62957130
X-ray abnormal 109.25 11.71 214 497792 7896 62983120
Musculoskeletal deformity 108.68 11.71 102 497904 1807 62989209
Injection site pain 108.62 11.71 586 497420 129214 62861802
Neutropenic sepsis 107.71 11.71 5 498001 16433 62974583
Incorrect dose administered 107.32 11.71 191 497815 59777 62931239
Transient ischaemic attack 106.34 11.71 84 497922 37669 62953347
Altered state of consciousness 105.82 11.71 33 497973 25197 62965819
Orthostatic hypotension 104.98 11.71 78 497928 36082 62954934
Lymphocyte count decreased 104.91 11.71 53 497953 30204 62960812
Tuberculin test positive 102.42 11.71 132 497874 3379 62987637
Blood potassium decreased 102.30 11.71 107 497899 41919 62949097
Inappropriate schedule of product administration 101.70 11.71 444 497562 103521 62887495
Weight decreased 100.90 11.71 1545 496461 275253 62715763
Creatinine renal clearance decreased 100.60 11.71 7 497999 16301 62974715
Acute myocardial infarction 100.31 11.71 64 497942 32060 62958956
Fine motor skill dysfunction 99.98 11.71 154 497852 4671 62986345
Nodule 99.65 11.71 377 497629 20649 62970367
Blood urea increased 99.58 11.71 41 497965 26338 62964678
Flatulence 99.28 11.71 76 497930 34626 62956390
Chronic kidney disease 99.25 11.71 126 497880 45272 62945744
Dysuria 98.95 11.71 72 497934 33666 62957350
Joint injury 98.91 11.71 477 497529 29095 62961921
Feeling hot 98.84 11.71 151 497855 50203 62940813
Upper gastrointestinal haemorrhage 98.57 11.71 15 497991 18837 62972179
Bone density decreased 98.54 11.71 295 497711 14317 62976699
Cytokine release syndrome 98.42 11.71 3 498003 14311 62976705
Foot deformity 98.06 11.71 456 497550 27397 62963619
SLE arthritis 97.80 11.71 63 497943 618 62990398
Diabetic ketoacidosis 97.11 11.71 21 497985 20484 62970532
Full blood count abnormal 96.58 11.71 65 497941 31652 62959364
Aggression 96.31 11.71 32 497974 23466 62967550
Accidental exposure to product 95.03 11.71 48 497958 27357 62963659
Small intestinal obstruction 94.94 11.71 15 497991 18322 62972694
Arrhythmia 94.09 11.71 96 497910 38044 62952972
Swelling face 93.46 11.71 226 497780 63249 62927767
Bone marrow failure 93.33 11.71 57 497949 29233 62961783
Drug level increased 93.12 11.71 31 497975 22705 62968311
Osteoporosis 92.80 11.71 768 497238 56570 62934446
Status epilepticus 92.64 11.71 7 497999 15226 62975790
Coronary artery disease 92.51 11.71 71 497935 32306 62958710
Chronic obstructive pulmonary disease 92.45 11.71 223 497783 62463 62928553
Hypervolaemia 92.35 11.71 54 497952 28359 62962657
Gastritis 91.90 11.71 94 497912 37209 62953807
Skin necrosis 91.59 11.71 279 497727 13671 62977345
Circulatory collapse 91.46 11.71 29 497977 21909 62969107
Speech disorder 90.67 11.71 111 497895 40518 62950498
Acute respiratory failure 90.66 11.71 82 497924 34403 62956613
Obstructive airways disorder 90.61 11.71 25 497981 20674 62970342
Respiratory depression 90.42 11.71 4 498002 13711 62977305
Night sweats 89.54 11.71 673 497333 48141 62942875
Tubulointerstitial nephritis 89.09 11.71 23 497983 19880 62971136
Product prescribing error 88.27 11.71 48 497958 26241 62964775
Blood creatinine increased 87.84 11.71 372 497634 87472 62903544
Adverse reaction 87.63 11.71 225 497781 9978 62981038
Muscle twitching 87.52 11.71 23 497983 19645 62971371
Dementia 87.49 11.71 20 497986 18774 62972242
Sciatica 87.02 11.71 513 497493 33811 62957205
Gamma-glutamyltransferase increased 87.01 11.71 83 497923 33948 62957068
Body height below normal 86.62 11.71 96 497910 2087 62988929
Acute hepatic failure 86.32 11.71 19 497987 18308 62972708
Withdrawal syndrome 85.96 11.71 25 497981 19972 62971044
Product administration error 85.86 11.71 34 497972 22363 62968653
Urinary incontinence 85.52 11.71 75 497931 31939 62959077
Renal phospholipidosis 85.35 11.71 32 497974 75 62990941
Hallucination, visual 85.05 11.71 23 497983 19275 62971741
Cardiac disorder 84.64 11.71 169 497837 50647 62940369
Cerebral infarction 84.13 11.71 41 497965 23852 62967164
Spinal stenosis 83.89 11.71 283 497723 14642 62976374
Therapy non-responder 83.88 11.71 938 497068 74963 62916053
Ischaemic stroke 83.81 11.71 19 497987 17938 62973078
Human antichimeric antibody positive 83.36 11.71 84 497922 1630 62989386
Eye disorder 83.28 11.71 376 497630 22309 62968707
Epilepsy 83.04 11.71 55 497951 27010 62964006
Electrolyte imbalance 82.88 11.71 27 497979 20049 62970967
Red blood cell sedimentation rate 81.68 11.71 141 497865 4713 62986303
Haematemesis 81.53 11.71 71 497935 30341 62960675
Drug eruption 81.42 11.71 442 497564 28252 62962764
Arthrodesis 81.22 11.71 105 497901 2696 62988320
Back pain 80.77 11.71 1522 496484 262623 62728393
Hemiparesis 80.40 11.71 41 497965 23241 62967775
Acute myeloid leukaemia 80.31 11.71 18 497988 17129 62973887
Myoclonus 79.89 11.71 14 497992 15854 62975162
Paraesthesia oral 79.31 11.71 26 497980 19230 62971786
Inappropriate antidiuretic hormone secretion 79.26 11.71 13 497993 15449 62975567
Neurotoxicity 79.25 11.71 18 497988 16972 62974044
Joint laxity 78.81 11.71 97 497909 2367 62988649
Seronegative arthritis 78.75 11.71 124 497882 3835 62987181
Sleep apnoea syndrome 78.12 11.71 68 497938 29065 62961951
Device related infection 78.12 11.71 43 497963 23349 62967667
Physical disability 78.11 11.71 102 497904 2646 62988370
Pancreatitis 77.61 11.71 168 497838 48887 62942129
Clostridium difficile colitis 77.59 11.71 32 497974 20537 62970479
Ulcer 77.38 11.71 407 497599 25700 62965316
Memory impairment 76.92 11.71 490 497516 103768 62887248
Rheumatoid lung 75.82 11.71 120 497886 3728 62987288
Oral mucosal exfoliation 74.89 11.71 78 497928 1576 62989440
Poisoning deliberate 74.87 11.71 3 498003 11215 62979801
Skin exfoliation 74.70 11.71 140 497866 42962 62948054
Rheumatoid factor negative 74.40 11.71 51 497955 560 62990456
Cellulitis 74.21 11.71 360 497646 81598 62909418
Oxygen saturation decreased 74.05 11.71 400 497606 88185 62902831
Surgical failure 73.81 11.71 61 497945 905 62990111
Abdominal pain lower 73.76 11.71 56 497950 25622 62965394
Device issue 73.40 11.71 48 497958 23733 62967283
Hepatocellular injury 73.31 11.71 64 497942 27317 62963699
Heart rate increased 73.12 11.71 436 497570 93802 62897214
Mental disorder 72.58 11.71 58 497948 25861 62965155
Ear pain 72.00 11.71 508 497498 35610 62955406
Depressed mood 71.92 11.71 128 497878 40063 62950953
Coordination abnormal 71.91 11.71 11 497995 13762 62977254
Abortion spontaneous 71.90 11.71 165 497841 47030 62943986
Mania 71.61 11.71 7 497999 12360 62978656
Complication associated with device 71.57 11.71 22 497984 16956 62974060
Gastrointestinal pain 71.33 11.71 203 497803 9573 62981443
Disseminated intravascular coagulation 71.28 11.71 30 497976 19021 62971995
Head injury 71.00 11.71 66 497940 27330 62963686
Herpes zoster 70.81 11.71 972 497034 81490 62909526
Diabetes mellitus inadequate control 70.60 11.71 16 497990 15110 62975906
Colitis microscopic 70.17 11.71 196 497810 9143 62981873
Wheelchair user 70.16 11.71 154 497852 6165 62984851
Wrist deformity 69.99 11.71 85 497921 2045 62988971
Muscle spasticity 69.64 11.71 347 497659 21447 62969569
Paranoia 69.26 11.71 6 498000 11673 62979343
Parkinsonism 68.97 11.71 3 498003 10436 62980580
Enthesopathy 68.92 11.71 185 497821 8429 62982587
Interstitial lung disease 68.82 11.71 766 497240 61142 62929874
Coagulopathy 68.26 11.71 38 497968 20506 62970510
Cholestasis 68.26 11.71 78 497928 29356 62961660
Blood sodium decreased 68.25 11.71 54 497952 24198 62966818
Hot flush 67.79 11.71 192 497814 50967 62940049
Sleep disorder 67.43 11.71 955 497051 80611 62910405
Thrombosis 67.37 11.71 270 497736 64485 62926531
Respiratory disorder 67.32 11.71 531 497475 38551 62952465
Metastases to central nervous system 67.22 11.71 11 497995 13094 62977922
Blood lactate dehydrogenase increased 66.93 11.71 50 497956 23066 62967950
Tachypnoea 66.76 11.71 26 497980 17276 62973740
Angioedema 66.56 11.71 176 497830 47789 62943227
Multiple sclerosis 66.43 11.71 56 497950 24316 62966700
Dyspnoea exertional 65.58 11.71 247 497759 60055 62930961
Hypophosphataemia 64.78 11.71 7 497999 11419 62979597
Vaginal haemorrhage 64.66 11.71 72 497934 27415 62963601
Dislocation of vertebra 64.66 11.71 181 497825 8454 62982562
Cyanosis 64.44 11.71 26 497980 16909 62974107
Spinal column injury 64.41 11.71 80 497926 1971 62989045
Extrapyramidal disorder 64.15 11.71 13 497993 13271 62977745
Mental impairment 64.02 11.71 16 497990 14135 62976881
Renal disorder 63.64 11.71 100 497906 32874 62958142
Leukocytosis 63.16 11.71 66 497940 25869 62965147
Blood triglycerides increased 62.91 11.71 11 497995 12477 62978539
Feeling cold 62.56 11.71 57 497949 23831 62967185
Loose body in joint 62.50 11.71 63 497943 1223 62989793
Blood pressure increased 62.30 11.71 895 497111 161167 62829849
Hyperthyroidism 61.88 11.71 19 497987 14654 62976362
Contusion 61.84 11.71 1578 496428 148466 62842550
Haematuria 61.60 11.71 83 497923 29074 62961942
Epicondylitis 61.51 11.71 81 497925 2119 62988897
Anuria 61.20 11.71 12 497994 12539 62978477
Subarachnoid haemorrhage 61.13 11.71 18 497988 14265 62976751
Glaucoma 61.11 11.71 302 497704 18603 62972413
Psychotic disorder 60.87 11.71 67 497939 25645 62965371
Device difficult to use 60.81 11.71 13 497993 12783 62978233
Anger 60.55 11.71 12 497994 12444 62978572
Pulmonary hypertension 60.51 11.71 125 497881 36998 62954018
Transfusion 60.17 11.71 22 497984 15195 62975821
Neuroleptic malignant syndrome 59.91 11.71 11 497995 12045 62978971
Cytomegalovirus infection 59.79 11.71 46 497960 20906 62970110
Blood glucose decreased 59.79 11.71 46 497960 20906 62970110
Pulmonary congestion 59.66 11.71 31 497975 17387 62973629
Macular degeneration 59.40 11.71 62 497944 24314 62966702
Intestinal obstruction 59.36 11.71 94 497912 30805 62960211
Investigation abnormal 59.30 11.71 75 497931 1883 62989133
Akathisia 59.22 11.71 3 498003 9143 62981873
Hypersomnia 59.12 11.71 34 497972 18021 62972995
Multiple fractures 59.07 11.71 175 497831 8443 62982573
Nightmare 58.89 11.71 39 497967 19155 62971861
Pollakiuria 58.54 11.71 80 497926 27857 62963159
Lip swelling 58.26 11.71 96 497910 30967 62960049
Muscle rigidity 58.22 11.71 10 497996 11490 62979526
Heart rate irregular 58.12 11.71 54 497952 22367 62968649
Frequent bowel movements 57.87 11.71 57 497949 22965 62968051
Hepatotoxicity 57.73 11.71 492 497514 36549 62954467
Injection site erythema 57.28 11.71 399 497607 82775 62908241
Onychomycosis 57.18 11.71 164 497842 7768 62983248
Incontinence 56.98 11.71 11 497995 11621 62979395
Metastases to lung 56.56 11.71 15 497991 12735 62978281
Hypothermia 56.53 11.71 18 497988 13563 62977453
Hepatic cytolysis 56.47 11.71 25 497981 15382 62975634
Pneumonia viral 56.34 11.71 163 497843 7759 62983257
Mouth ulceration 56.18 11.71 447 497559 32537 62958479
Muscular weakness 56.15 11.71 651 497355 121702 62869314
Malnutrition 55.79 11.71 25 497981 15273 62975743
Skin discolouration 55.43 11.71 135 497871 37693 62953323
Therapy cessation 55.40 11.71 96 497910 30361 62960655
Mydriasis 55.10 11.71 13 497993 11943 62979073
Hepatitis 55.08 11.71 515 497491 39273 62951743
Vascular access complication 54.66 11.71 75 497931 2043 62988973
Poisoning 53.84 11.71 20 497986 13680 62977336
Eye swelling 53.73 11.71 65 497941 23853 62967163
Angina pectoris 53.63 11.71 96 497910 29982 62961034
Eye pruritus 53.27 11.71 41 497965 18630 62972386
Red cell distribution width decreased 53.11 11.71 73 497933 1992 62989024
Body temperature increased 52.79 11.71 484 497522 36708 62954308
Blood magnesium decreased 52.32 11.71 19 497987 13179 62977837
Ileus 52.25 11.71 25 497981 14700 62976316
Basal cell carcinoma 51.94 11.71 387 497619 27604 62963412
Haemoptysis 51.84 11.71 91 497915 28635 62962381
Amenorrhoea 51.58 11.71 8 497998 9906 62981110
Breast cancer stage III 51.53 11.71 189 497817 10197 62980819
Viral upper respiratory tract infection 51.20 11.71 155 497851 7569 62983447
Infective pulmonary exacerbation of cystic fibrosis 51.03 11.71 5 498001 8812 62982204
Back injury 50.66 11.71 179 497827 9481 62981535
Labelled drug-drug interaction medication error 50.29 11.71 21 497985 13378 62977638
Second primary malignancy 50.28 11.71 3 498003 7950 62983066
Clostridium difficile infection 50.27 11.71 99 497907 29823 62961193
Haematotoxicity 50.09 11.71 7 497999 9369 62981647
Nervousness 49.91 11.71 105 497901 30874 62960142
Ejection fraction decreased 49.84 11.71 61 497945 22271 62968745
Therapy interrupted 49.82 11.71 113 497893 32342 62958674
Anal incontinence 49.80 11.71 22 497984 13554 62977462
Foot operation 49.72 11.71 147 497859 7084 62983932
Shock haemorrhagic 49.23 11.71 9 497997 9886 62981130
Ataxia 49.21 11.71 29 497977 15166 62975850
Aplastic anaemia 49.15 11.71 8 497998 9561 62981455
Blood creatine phosphokinase increased 49.15 11.71 103 497903 30327 62960689
Haemorrhage intracranial 48.83 11.71 22 497984 13397 62977619
Retching 48.79 11.71 27 497979 14618 62976398
Panic attack 48.78 11.71 62 497944 22269 62968747
Dialysis 48.73 11.71 11 497995 10416 62980600
Fear of injection 48.65 11.71 145 497861 7019 62983997
Myelosuppression 48.54 11.71 69 497937 23634 62967382
Pancreatitis acute 48.17 11.71 87 497919 27079 62963937
Blood albumin decreased 48.08 11.71 28 497978 14738 62976278
Hypothyroidism 48.08 11.71 172 497834 42460 62948556
Ankle arthroplasty 48.00 11.71 65 497941 1748 62989268
Mood altered 47.94 11.71 28 497978 14715 62976301
Hypoacusis 47.80 11.71 72 497934 24079 62966937
Product label confusion 47.75 11.71 65 497941 1757 62989259
Aspartate aminotransferase increased 47.62 11.71 465 497541 89812 62901204
Retinitis 47.50 11.71 131 497875 6065 62984951
Presyncope 47.48 11.71 91 497915 27694 62963322
Glomerular filtration rate decreased 47.42 11.71 23 497983 13418 62977598
Hip fracture 47.40 11.71 100 497906 29374 62961642
Prescribed underdose 47.14 11.71 396 497610 29293 62961723
Hepatic encephalopathy 46.88 11.71 15 497991 11267 62979749
Mean platelet volume decreased 46.85 11.71 79 497927 2590 62988426
Dystonia 46.73 11.71 25 497981 13794 62977222
Diplopia 46.71 11.71 71 497935 23657 62967359
Alanine aminotransferase increased 46.11 11.71 556 497450 103214 62887802
Brain oedema 46.10 11.71 27 497979 14168 62976848
Lymphoedema 46.07 11.71 17 497989 11675 62979341
Bacteraemia 45.90 11.71 41 497965 17307 62973709
Aspiration 45.85 11.71 14 497992 10837 62980179
Loss of consciousness 45.85 11.71 651 497355 117470 62873546
Thrombotic microangiopathy 45.77 11.71 13 497993 10548 62980468
International normalised ratio fluctuation 45.71 11.71 75 497931 2403 62988613
Rash erythematous 45.65 11.71 175 497831 42335 62948681
Shock 45.43 11.71 71 497935 23392 62967624
Nervous system disorder 45.42 11.71 48 497958 18718 62972298
Sinus bradycardia 45.41 11.71 29 497977 14522 62976494
Face oedema 45.33 11.71 55 497951 20157 62970859
Influenza 45.15 11.71 591 497415 108131 62882885
Hypoalbuminaemia 45.12 11.71 18 497988 11787 62979229
Pericardial effusion 45.05 11.71 106 497900 29952 62961064
Rash macular 44.95 11.71 71 497935 23293 62967723
Hypoaesthesia 44.66 11.71 993 497013 167400 62823616
Hospice care 44.62 11.71 5 498001 7927 62983089
Sinus tachycardia 44.59 11.71 76 497930 24192 62966824
Anticipatory anxiety 44.53 11.71 52 497954 1199 62989817
Synovial cyst 44.52 11.71 181 497825 10252 62980764
Onychomadesis 44.30 11.71 123 497883 5717 62985299
Anti-cyclic citrullinated peptide antibody 44.22 11.71 135 497871 6623 62984393
Polyuria 44.20 11.71 7 497999 8535 62982481
Subdural haematoma 44.11 11.71 29 497977 14299 62976717
Faeces discoloured 44.07 11.71 48 497958 18461 62972555
Pulmonary arterial hypertension 44.02 11.71 68 497938 22509 62968507
Device malfunction 43.98 11.71 45 497961 17812 62973204
Infusion site reaction 43.96 11.71 91 497915 3496 62987520
Seasonal allergy 43.89 11.71 60 497946 20890 62970126
Supraventricular tachycardia 43.78 11.71 29 497977 14242 62976774
Throat irritation 43.72 11.71 150 497856 37497 62953519
Bone swelling 43.63 11.71 60 497946 1638 62989378
Acquired pigmented retinopathy 43.62 11.71 12 497994 3 62991013
Cholecystitis 43.57 11.71 34 497972 15343 62975673
Antibody test positive 43.43 11.71 77 497929 2630 62988386
Ageusia 43.34 11.71 27 497979 13701 62977315
Infusion site pain 43.29 11.71 41 497965 16828 62974188
Delusion 43.26 11.71 20 497986 11997 62979019
Burning sensation 43.10 11.71 250 497756 54157 62936859
Caesarean section 43.01 11.71 42 497964 16990 62974026
Procedural pain 42.98 11.71 64 497942 21505 62969511
Jaundice cholestatic 42.79 11.71 4 498002 7320 62983696
Cholecystitis chronic 42.65 11.71 14 497992 10347 62980669
Drug reaction with eosinophilia and systemic symptoms 42.64 11.71 130 497876 33706 62957310
Ocular toxicity 42.48 11.71 39 497967 671 62990345
Urine output decreased 42.39 11.71 18 497988 11352 62979664
Lacrimation increased 42.31 11.71 60 497946 20571 62970445
Faecaloma 42.25 11.71 6 498000 7935 62983081
Wheezing 42.17 11.71 513 497493 95082 62895934
Hypoaesthesia oral 42.03 11.71 25 497981 13008 62978008
Abnormal dreams 41.92 11.71 15 497991 10501 62980515
Mesenteritis 41.73 11.71 28 497978 296 62990720
Bloody discharge 41.66 11.71 56 497950 1495 62989521
Enterocolitis 41.66 11.71 6 498000 7852 62983164
Influenza like illness 41.51 11.71 330 497676 66494 62924522
Metastases to lymph nodes 41.51 11.71 7 497999 8151 62982865
Graft versus host disease 41.43 11.71 3 498003 6760 62984256
Lipase increased 41.42 11.71 13 497993 9887 62981129
Live birth 41.30 11.71 343 497663 25287 62965729
Acute coronary syndrome 41.13 11.71 14 497992 10112 62980904
Thirst 41.13 11.71 30 497976 14011 62977005
Glycosylated haemoglobin increased 41.09 11.71 23 497983 12375 62978641
Mycotic allergy 41.09 11.71 45 497961 965 62990051
Dysphonia 40.89 11.71 213 497793 47401 62943615
Neck pain 40.31 11.71 766 497240 68552 62922464
Cardiogenic shock 40.00 11.71 49 497957 17883 62973133
Nasal congestion 39.98 11.71 326 497680 65334 62925682
Subacute cutaneous lupus erythematosus 39.63 11.71 73 497933 2570 62988446
Breast cancer stage I 39.63 11.71 4 498002 6885 62984131
Myocardial ischaemia 39.62 11.71 26 497980 12833 62978183
Injection site mass 39.52 11.71 53 497953 18603 62972413
Lupus vasculitis 39.50 11.71 34 497972 535 62990481
Ovarian neoplasm 39.46 11.71 42 497964 871 62990145
Hemiplegia 39.45 11.71 12 497994 9311 62981705
Renal tubular necrosis 39.42 11.71 22 497984 11856 62979160
Hallucination, auditory 39.42 11.71 26 497980 12798 62978218
Troponin increased 39.40 11.71 15 497991 10106 62980910
Needle issue 39.37 11.71 16 497990 10360 62980656
Right ventricular failure 39.37 11.71 46 497960 17142 62973874
Staphylococcal infection 39.23 11.71 178 497828 41078 62949938
Heavy menstrual bleeding 39.18 11.71 49 497957 17724 62973292
Lupus-like syndrome 39.02 11.71 229 497777 15066 62975950
Incorrect product administration duration 38.88 11.71 21 497985 11525 62979491
Device breakage 38.85 11.71 21 497985 11521 62979495
Breast cancer metastatic 38.83 11.71 23 497983 11995 62979021
Haemodialysis 38.80 11.71 11 497995 8936 62982080
Infusion site erythema 38.23 11.71 22 497984 11657 62979359
Myelodysplastic syndrome 38.20 11.71 45 497961 16709 62974307
Agranulocytosis 38.18 11.71 88 497918 25046 62965970
Hypovolaemia 38.06 11.71 18 497988 10655 62980361
Pemphigoid 38.04 11.71 6 498000 7338 62983678
Cholecystitis acute 38.03 11.71 9 497997 8251 62982765
Pain in extremity 38.02 11.71 3056 494950 328430 62662586
Psychomotor hyperactivity 37.99 11.71 18 497988 10645 62980371
Bone density abnormal 37.94 11.71 83 497923 3315 62987701
Presbyacusis 37.86 11.71 75 497931 2790 62988226
Joint arthroplasty 37.74 11.71 73 497933 2668 62988348
Personality change 37.74 11.71 5 498001 6968 62984048
Mean cell volume decreased 37.61 11.71 91 497915 3887 62987129
Hyperbilirubinaemia 37.49 11.71 21 497985 11293 62979723
Upper respiratory tract infection 37.45 11.71 437 497569 81610 62909406
Stevens-Johnson syndrome 37.38 11.71 88 497918 24862 62966154
Rhinitis allergic 37.11 11.71 23 497983 11704 62979312
Hypocalcaemia 37.07 11.71 126 497880 31587 62959429
Anhedonia 36.89 11.71 20 497986 10954 62980062
Vaginal discharge 36.87 11.71 13 497993 9185 62981831
Drug use disorder 36.85 11.71 104 497902 4880 62986136
Visual acuity reduced 36.85 11.71 72 497934 21754 62969262
Tinnitus 36.77 11.71 149 497857 35479 62955537
Colitis ischaemic 36.76 11.71 19 497987 10689 62980327
Drug resistance 36.72 11.71 78 497928 22855 62968161
White blood cell count increased 36.44 11.71 227 497779 48334 62942682
Throat tightness 36.32 11.71 89 497917 24798 62966218
Central nervous system lesion 36.32 11.71 19 497987 10616 62980400
Skin burning sensation 36.28 11.71 28 497978 12706 62978310
Salivary hypersecretion 36.00 11.71 8 497998 7658 62983358
Intermenstrual bleeding 35.78 11.71 9 497997 7917 62983099
Neck mass 35.77 11.71 84 497922 3519 62987497
Laboratory test abnormal 35.65 11.71 101 497905 26811 62964205
Motor dysfunction 35.61 11.71 20 497986 10741 62980275
Acidosis 35.59 11.71 22 497984 11211 62979805
Cystitis 35.35 11.71 269 497737 54722 62936294
Hyperreflexia 35.32 11.71 3 498003 5931 62985085
Sensitivity to weather change 35.32 11.71 131 497875 7106 62983910
Taste disorder 35.30 11.71 33 497973 13629 62977387
Eosinophil count increased 35.19 11.71 21 497985 10907 62980109
Pleural thickening 35.16 11.71 73 497933 2810 62988206
Premature labour 34.99 11.71 28 497978 12476 62978540
Laryngeal disorder 34.92 11.71 42 497964 1000 62990016
Transaminases abnormal 34.91 11.71 34 497972 632 62990384
Wound infection 34.75 11.71 287 497719 21123 62969893
Pleural fibrosis 34.53 11.71 81 497925 3391 62987625
Asphyxia 34.51 11.71 4 498002 6177 62984839
Unintended pregnancy 34.49 11.71 4 498002 6175 62984841
Fracture 34.47 11.71 63 497943 19521 62971495
Arteriosclerosis 34.35 11.71 18 497988 10048 62980968
Eosinophilia 34.30 11.71 80 497926 22676 62968340
Prothrombin time prolonged 34.30 11.71 16 497990 9548 62981468
Diarrhoea haemorrhagic 34.21 11.71 14 497992 9028 62981988
Sensory disturbance 34.19 11.71 34 497972 13638 62977378
Eye pain 34.05 11.71 143 497863 33711 62957305
Brain injury 33.79 11.71 7 497999 7036 62983980
Sudden death 33.76 11.71 20 497986 10429 62980587
Acute pulmonary oedema 33.63 11.71 11 497995 8147 62982869
Sinus disorder 33.38 11.71 91 497915 24462 62966554
Sickle cell anaemia with crisis 33.23 11.71 4 498002 5999 62985017
Petechiae 33.13 11.71 36 497970 13861 62977155
Anovulatory cycle 33.02 11.71 19 497987 149 62990867
Oliguria 32.99 11.71 15 497991 9086 62981930
Blood calcium increased 32.98 11.71 16 497990 9334 62981682
Klebsiella infection 32.84 11.71 13 497993 8553 62982463
Prescribed overdose 32.82 11.71 411 497595 33742 62957274
Gastrointestinal toxicity 32.80 11.71 134 497872 7607 62983409
Activated partial thromboplastin time prolonged 32.76 11.71 7 497999 6886 62984130
Toxic encephalopathy 32.70 11.71 6 498000 6573 62984443
Musculoskeletal chest pain 32.69 11.71 73 497933 21010 62970006
Hypotonia 32.59 11.71 16 497990 9269 62981747
Osteoporotic fracture 32.57 11.71 83 497923 3663 62987353
Eyelid oedema 32.54 11.71 21 497985 10458 62980558
Hiatus hernia 32.48 11.71 76 497930 21518 62969498
Extremity contracture 32.41 11.71 45 497961 1240 62989776
Restrictive cardiomyopathy 32.23 11.71 24 497982 303 62990713
Device leakage 32.14 11.71 8 497998 7088 62983928
Stress cardiomyopathy 32.10 11.71 17 497989 9433 62981583
Renal injury 32.03 11.71 17 497989 9422 62981594
Haemodynamic instability 32.01 11.71 16 497990 9174 62981842
Bronchospasm 31.85 11.71 54 497952 17226 62973790
Metabolic encephalopathy 31.84 11.71 4 498002 5805 62985211
Muscle tightness 31.63 11.71 28 497978 11872 62979144
Transplant rejection 31.62 11.71 23 497983 10757 62980259
Drug specific antibody 31.55 11.71 62 497944 2293 62988723
Bradyphrenia 31.37 11.71 8 497998 6972 62984044
Product substitution issue 31.36 11.71 48 497958 15948 62975068
Pulseless electrical activity 31.25 11.71 10 497996 7511 62983505
Cold sweat 31.24 11.71 29 497977 12018 62978998
Product storage error 31.16 11.71 43 497963 14913 62976103
Dermatomyositis 31.16 11.71 69 497937 2779 62988237
Hypomania 30.98 11.71 6 498000 6324 62984692
Hydronephrosis 30.95 11.71 23 497983 10639 62980377
Failure to thrive 30.94 11.71 9 497997 7189 62983827
Delirium 30.74 11.71 251 497755 50290 62940726
Post procedural haemorrhage 30.68 11.71 12 497994 7952 62983064
Suspected suicide 30.55 11.71 7 497999 6561 62984455
Fungal infection 30.53 11.71 167 497839 36707 62954309
Soft tissue disorder 30.50 11.71 90 497916 4332 62986684
Facet joint syndrome 30.49 11.71 181 497825 11957 62979059
Hair follicle tumour benign 30.42 11.71 26 497980 405 62990611
Drug level decreased 30.39 11.71 12 497994 7907 62983109
Fear 30.25 11.71 48 497958 15718 62975298
Infiltration anaesthesia 30.22 11.71 19 497987 178 62990838
Lower gastrointestinal haemorrhage 30.21 11.71 12 497994 7878 62983138
Pharyngitis 30.05 11.71 265 497741 19878 62971138
Rash papular 29.94 11.71 48 497958 15654 62975362
Metastasis 29.94 11.71 3 498003 5194 62985822
Bradykinesia 29.87 11.71 3 498003 5185 62985831
Tender joint count 29.84 11.71 20 497986 211 62990805
Overlap syndrome 29.84 11.71 36 497970 860 62990156
Sensory loss 29.82 11.71 22 497984 10216 62980800
Chronic sinusitis 29.81 11.71 34 497972 12809 62978207
Thinking abnormal 29.57 11.71 24 497982 10619 62980397
Hyperventilation 29.50 11.71 6 498000 6110 62984906
Adjustment disorder with depressed mood 29.50 11.71 158 497848 10046 62980970
Proctalgia 29.46 11.71 6 498000 6104 62984912
Oesophagitis 29.45 11.71 45 497961 14963 62976053
Large intestine perforation 29.19 11.71 15 497991 8467 62982549
Device use error 29.18 11.71 5 498001 5756 62985260
Sneezing 29.14 11.71 62 497944 18156 62972860
Eczema 29.13 11.71 142 497864 32149 62958867
Gingivitis 28.87 11.71 15 497991 8414 62982602
Cutaneous vasculitis 28.81 11.71 99 497907 5170 62985846
Lung disorder 28.70 11.71 665 497341 61596 62929420
Ear infection 28.66 11.71 440 497566 37773 62953243
Neck deformity 28.61 11.71 56 497950 2065 62988951
Product physical issue 28.37 11.71 3 498003 4977 62986039
Neutrophil count increased 28.35 11.71 54 497952 16473 62974543
Mass excision 28.29 11.71 23 497983 333 62990683
Metabolic disorder 28.19 11.71 8 497998 6495 62984521
Fistula 28.18 11.71 24 497982 10369 62980647
Obesity 28.17 11.71 359 497647 29593 62961423
Neoplasm malignant 28.12 11.71 358 497648 29503 62961513
Deafness neurosensory 28.12 11.71 93 497913 4762 62986254
Toxic epidermal necrolysis 28.04 11.71 103 497903 25231 62965785
Pelvic pain 28.04 11.71 39 497967 13480 62977536
Haemorrhoids 27.98 11.71 85 497921 22065 62968951
Thyroid neoplasm 27.92 11.71 82 497924 3937 62987079
Crohn's disease 27.88 11.71 3 498003 4910 62986106
Myopathy toxic 27.67 11.71 27 497979 503 62990513
Diffuse alopecia 27.60 11.71 35 497971 881 62990135
Bronchitis chronic 27.59 11.71 86 497920 4267 62986749
Affect lability 27.58 11.71 28 497978 11123 62979893
Hyperthermia 27.56 11.71 19 497987 9137 62981879
Head discomfort 27.52 11.71 39 497967 13376 62977640
Chromaturia 27.49 11.71 56 497950 16661 62974355
Hepatic enzyme abnormal 27.36 11.71 111 497895 6281 62984735
Application site erythema 27.32 11.71 3 498003 4832 62986184
Venoocclusive liver disease 27.32 11.71 3 498003 4832 62986184
Wrist surgery 27.27 11.71 34 497972 841 62990175
Large intestine polyp 27.23 11.71 15 497991 8142 62982874
Electrocardiogram U-wave abnormality 27.10 11.71 10 497996 22 62990994
Device occlusion 27.05 11.71 12 497994 7375 62983641
Pancreatic carcinoma 26.99 11.71 13 497993 7615 62983401
Nasal polyps 26.99 11.71 7 497999 6032 62984984
Hypercapnia 26.89 11.71 5 498001 5426 62985590
Injection site haemorrhage 26.82 11.71 99 497907 24215 62966801
White blood cell count abnormal 26.47 11.71 8 497998 6234 62984782
Bursitis 26.45 11.71 423 497583 36618 62954398
Optical coherence tomography abnormal 26.37 11.71 9 497997 14 62991002
Mean cell haemoglobin decreased 26.33 11.71 95 497911 5084 62985932
Deep vein thrombosis postoperative 26.33 11.71 166 497840 11203 62979813
Post transplant lymphoproliferative disorder 26.31 11.71 4 498002 5027 62985989
Pregnancy with contraceptive device 26.30 11.71 3 498003 4691 62986325
Oropharyngeal pain 26.24 11.71 553 497453 93934 62897082
Weight fluctuation 26.23 11.71 23 497983 9796 62981220
Systemic infection 26.05 11.71 3 498003 4657 62986359
Peripheral sensory neuropathy 25.91 11.71 13 497993 7438 62983578
Exposure to toxic agent 25.90 11.71 6 498000 5581 62985435
Amnesia 25.78 11.71 295 497711 55290 62935726
Neuralgia 25.78 11.71 110 497896 25816 62965200
Cholangitis 25.72 11.71 6 498000 5555 62985461
Heart rate abnormal 25.72 11.71 4 498002 4943 62986073
Body tinea 25.71 11.71 50 497956 1835 62989181
Skin reaction 25.70 11.71 202 497804 14647 62976369
Vasculitic rash 25.68 11.71 42 497964 1342 62989674
Partial seizures 25.67 11.71 7 497999 5835 62985181
Somnambulism 25.60 11.71 6 498000 5537 62985479
Skin ulcer 25.48 11.71 477 497529 42568 62948448
Myocarditis 25.45 11.71 26 497980 10299 62980717
Blood glucose fluctuation 25.45 11.71 3 498003 4573 62986443
Drug tolerance 25.37 11.71 115 497891 6834 62984182
Peritonitis 25.30 11.71 61 497945 17093 62973923
Ileus paralytic 25.27 11.71 3 498003 4548 62986468
Femoral neck fracture 25.24 11.71 18 497988 8505 62982511
Female genital tract fistula 25.09 11.71 14 497992 7545 62983471
Lung infiltration 25.04 11.71 47 497959 14416 62976600
Cartilage atrophy 25.00 11.71 16 497990 155 62990861
Coma scale abnormal 24.97 11.71 5 498001 5148 62985868
Cutaneous coccidioidomycosis 24.96 11.71 9 497997 18 62990998
Hallucinations, mixed 24.89 11.71 4 498002 4825 62986191
Hepatic lesion 24.86 11.71 4 498002 4821 62986195
Eyelid ptosis 24.79 11.71 13 497993 7254 62983762
Hypovolaemic shock 24.71 11.71 9 497997 6232 62984784
Foetal exposure during pregnancy 24.71 11.71 148 497858 31814 62959202
Menstruation irregular 24.69 11.71 12 497994 6992 62984024
Injection site swelling 24.67 11.71 246 497760 47326 62943690
Phospholipidosis 24.67 11.71 16 497990 159 62990857
Underdose 24.61 11.71 121 497885 27335 62963681
Malaise 24.55 11.71 2872 495134 413082 62577934
Dermatitis atopic 24.53 11.71 24 497982 9700 62981316
Disease susceptibility 24.47 11.71 17 497989 191 62990825
Respiratory acidosis 24.45 11.71 11 497995 6704 62984312
Pathological fracture 24.44 11.71 20 497986 8814 62982202
Hyperuricaemia 24.43 11.71 6 498000 5364 62985652
Arteriosclerosis coronary artery 24.38 11.71 18 497988 8355 62982661
Lip dry 24.37 11.71 206 497800 15264 62975752
Nephropathy toxic 24.37 11.71 23 497983 9456 62981560
Blood thyroid stimulating hormone increased 24.35 11.71 13 497993 7181 62983835
Generalised oedema 24.34 11.71 55 497951 15763 62975253
Apathy 24.22 11.71 20 497986 8774 62982242
Restless legs syndrome 24.21 11.71 70 497936 18461 62972555
Cardiomegaly 24.16 11.71 65 497941 17549 62973467
Gastric cancer 24.15 11.71 4 498002 4719 62986297
Blood loss anaemia 24.14 11.71 21 497985 8980 62982036
Product adhesion issue 24.12 11.71 4 498002 4715 62986301
Histoplasmosis disseminated 24.12 11.71 42 497964 1414 62989602
Pruritus allergic 24.10 11.71 44 497962 1538 62989478
Viral infection 24.10 11.71 172 497834 35491 62955525
Blood magnesium increased 24.06 11.71 65 497941 2973 62988043
Productive cough 23.94 11.71 350 497656 62858 62928158
Micturition urgency 23.92 11.71 24 497982 9587 62981429
Spinal fracture 23.89 11.71 69 497937 18202 62972814
Ankle operation 23.81 11.71 39 497967 1248 62989768
Product preparation error 23.76 11.71 9 497997 6083 62984933
Extra dose administered 23.76 11.71 10 497996 6340 62984676
Retinal degeneration 23.73 11.71 32 497974 857 62990159
Therapy change 23.69 11.71 9 497997 6072 62984944
Major depression 23.66 11.71 17 497989 8001 62983015
Lung neoplasm malignant 23.63 11.71 77 497929 19556 62971460
Lyme disease 23.60 11.71 70 497936 3379 62987637
Ocular hyperaemia 23.60 11.71 109 497897 25035 62965981
Hypertonia 23.54 11.71 4 498002 4633 62986383
Septic shock 23.51 11.71 374 497632 66255 62924761
Diverticulum 23.49 11.71 36 497970 11955 62979061
Immune thrombocytopenia 23.38 11.71 29 497977 10527 62980489
Respiratory syncytial virus infection 23.29 11.71 13 497993 7005 62984011
Lupus vulgaris 23.25 11.71 101 497905 5893 62985123
Aplasia 23.18 11.71 3 498003 4256 62986760
Skin haemorrhage 23.13 11.71 27 497979 10067 62980949
Injection site reaction 23.07 11.71 612 497394 57912 62933104
Proctitis 23.03 11.71 7 497999 5434 62985582
Butterfly rash 22.94 11.71 46 497960 1727 62989289
Cushingoid 22.93 11.71 129 497877 8356 62982660
Mycobacterium tuberculosis complex test positive 22.91 11.71 53 497953 2198 62988818
Faeces soft 22.89 11.71 8 497998 5684 62985332
Blindness 22.87 11.71 90 497916 21609 62969407
Lupus myocarditis 22.82 11.71 11 497995 57 62990959
Blood urine present 22.69 11.71 53 497953 15016 62976000
Application site pain 22.63 11.71 3 498003 4179 62986837
Respiration abnormal 22.61 11.71 11 497995 6406 62984610
Food allergy 22.55 11.71 34 497972 11367 62979649
Nail disorder 22.50 11.71 177 497829 12838 62978178
Cutaneous lupus erythematosus 22.46 11.71 59 497947 2653 62988363
Wrong product administered 22.45 11.71 10 497996 6131 62984885
Apnoea 22.40 11.71 18 497988 8004 62983012
Intestinal sepsis 22.39 11.71 19 497987 293 62990723
Skin irritation 22.38 11.71 26 497980 9715 62981301
Alanine aminotransferase abnormal 22.38 11.71 82 497924 4422 62986594
Mood swings 22.36 11.71 71 497935 18177 62972839
Tricuspid valve incompetence 22.36 11.71 51 497955 14570 62976446
Cardiac failure acute 22.34 11.71 25 497981 9498 62981518
Toxic skin eruption 22.19 11.71 42 497964 12843 62978173
Amylase increased 22.17 11.71 11 497995 6334 62984682
Duodenal ulcer 22.17 11.71 17 497989 7739 62983277
Gastric ulcer 22.09 11.71 105 497901 23932 62967084
Depressive symptom 22.06 11.71 3 498003 4099 62986917
Allergy to chemicals 22.03 11.71 63 497943 2979 62988037
Gingival pain 21.94 11.71 19 497987 8143 62982873
Gallbladder disorder 21.93 11.71 75 497931 18767 62972249
Long QT syndrome 21.92 11.71 66 497940 3213 62987803
COVID-19 treatment 21.87 11.71 13 497993 109 62990907
Blood pressure inadequately controlled 21.81 11.71 6 498000 4972 62986044
Rib fracture 21.78 11.71 97 497909 22500 62968516
Bone cyst 21.78 11.71 52 497954 2202 62988814
Ketoacidosis 21.74 11.71 4 498002 4374 62986642
Left ventricular dysfunction 21.61 11.71 38 497968 11950 62979066
Diverticulitis 21.60 11.71 433 497573 39124 62951892
Hypercalcaemia 21.58 11.71 327 497679 27995 62963021
Cerebral ischaemia 21.56 11.71 13 497993 6715 62984301
Coeliac disease 21.56 11.71 173 497833 12624 62978392
Diabetic eye disease 21.51 11.71 14 497992 140 62990876
Polyneuropathy 21.42 11.71 52 497954 14537 62976479
Atrial septal defect 21.42 11.71 14 497992 6924 62984092
Medication error 21.41 11.71 285 497721 51999 62939017
Nystagmus 21.41 11.71 11 497995 6209 62984807
Tuberculosis 21.37 11.71 156 497850 11055 62979961
Multiple-drug resistance 21.26 11.71 7 497999 5163 62985853
Synovial fluid analysis 21.25 11.71 54 497952 2379 62988637
Hepatic necrosis 21.20 11.71 9 497997 5678 62985338
Product residue present 21.19 11.71 3 498003 3976 62987040
Expired product administered 21.17 11.71 11 497995 6170 62984846
Granulocytopenia 21.11 11.71 9 497997 5663 62985353
Joint dislocation 21.06 11.71 233 497773 18567 62972449
Palindromic rheumatism 21.04 11.71 16 497990 209 62990807
Anosmia 20.96 11.71 14 497992 6846 62984170
Blood lactic acid increased 20.94 11.71 15 497991 7071 62983945
Electrocardiogram ST segment elevation 20.82 11.71 3 498003 3924 62987092
Eye irritation 20.77 11.71 95 497911 21876 62969140
Exostosis 20.76 11.71 223 497783 17639 62973377
Incoherent 20.73 11.71 5 498001 4525 62986491
Unevaluable event 20.71 11.71 281 497725 51105 62939911
Accident 20.68 11.71 98 497908 5934 62985082
Drug level above therapeutic 20.67 11.71 6 498000 4799 62986217
Dermatitis contact 20.66 11.71 34 497972 10974 62980042
Nocardiosis 20.64 11.71 47 497959 1929 62989087
Gait inability 20.64 11.71 553 497453 52406 62938610
Cerebral atrophy 20.58 11.71 7 497999 5059 62985957
Intestinal ischaemia 20.55 11.71 17 497989 7451 62983565
Facial pain 20.41 11.71 32 497974 10529 62980487
Infective exacerbation of bronchiectasis 20.36 11.71 19 497987 334 62990682
Polycystic ovaries 20.33 11.71 5 498001 4466 62986550
Atrioventricular block 20.32 11.71 18 497988 7629 62983387
Blood immunoglobulin E increased 20.27 11.71 3 498003 3846 62987170
Stress at work 20.23 11.71 35 497971 1172 62989844
Dyslipidaemia 20.13 11.71 17 497989 7376 62983640
Fundoscopy abnormal 20.10 11.71 7 497999 12 62991004
Exercise tolerance decreased 20.02 11.71 9 497997 5488 62985528
Hypopnoea 19.96 11.71 3 498003 3803 62987213
Escherichia infection 19.90 11.71 44 497962 12710 62978306
Migraine 19.88 11.71 638 497368 102708 62888308
Parosmia 19.88 11.71 12 497994 6194 62984822
Sinus congestion 19.85 11.71 74 497932 18049 62972967
Vitamin D decreased 19.82 11.71 31 497975 10211 62980805
Clostridial infection 19.80 11.71 5 498001 4387 62986629
Pneumonia fungal 19.76 11.71 9 497997 5446 62985570
Vascular device infection 19.68 11.71 17 497989 7295 62983721
Chorioretinitis 19.65 11.71 24 497982 581 62990435
Brain neoplasm 19.63 11.71 5 498001 4361 62986655
Uterine leiomyoma 19.61 11.71 26 497980 9172 62981844
Initial insomnia 19.59 11.71 12 497994 6145 62984871
Gastric ulcer haemorrhage 19.57 11.71 7 497999 4901 62986115
Internal haemorrhage 19.54 11.71 8 497998 5157 62985859
Pustular psoriasis 19.54 11.71 80 497926 4546 62986470
Affective disorder 19.52 11.71 12 497994 6134 62984882
Juvenile idiopathic arthritis 19.52 11.71 64 497942 3262 62987754
Atrioventricular block first degree 19.47 11.71 17 497989 7256 62983760
Atrial flutter 19.47 11.71 29 497977 9743 62981273
Infusion site swelling 19.46 11.71 29 497977 9741 62981275
Hypokinesia 19.44 11.71 51 497955 13885 62977131
Eructation 19.41 11.71 22 497984 8311 62982705
Peritonitis bacterial 19.38 11.71 7 497999 4872 62986144
Tenderness 19.31 11.71 266 497740 22312 62968704
Macular telangiectasia 19.28 11.71 5 498001 0 62991016
Vitamin D deficiency 19.25 11.71 51 497955 13841 62977175
Weight increased 19.12 11.71 2331 495675 258461 62732555
Facial paralysis 19.12 11.71 52 497954 13989 62977027
Hypoxic-ischaemic encephalopathy 19.10 11.71 5 498001 4282 62986734
Atelectasis 19.07 11.71 95 497911 21388 62969628
Hypertensive crisis 19.07 11.71 59 497947 15227 62975789
Application site pruritus 19.03 11.71 4 498002 3980 62987036
Colon cancer 19.02 11.71 30 497976 9848 62981168
Anterior chamber cleavage syndrome 18.98 11.71 14 497992 174 62990842
Bladder cancer 18.92 11.71 10 497996 5556 62985460
Posterior reversible encephalopathy syndrome 18.88 11.71 71 497935 17274 62973742
Bronchopleural fistula 18.86 11.71 15 497991 210 62990806
Bacterial test positive 18.85 11.71 9 497997 5298 62985718
Atrial tachycardia 18.79 11.71 5 498001 4235 62986781
Immunosuppressant drug level increased 18.78 11.71 3 498003 3635 62987381
Device failure 18.73 11.71 12 497994 5999 62985017
Drug screen positive 18.72 11.71 3 498003 3626 62987390
Fibrin D dimer increased 18.72 11.71 8 497998 5026 62985990
Ischaemia 18.70 11.71 7 497999 4765 62986251
Oral discomfort 18.68 11.71 130 497876 9071 62981945
Breast cancer female 18.62 11.71 50 497956 13509 62977507
Bipolar disorder 18.56 11.71 21 497985 7939 62983077
Atrioventricular block second degree 18.55 11.71 4 498002 3910 62987106
Coronary artery stenosis 18.52 11.71 7 497999 4737 62986279
Transaminases increased 18.52 11.71 157 497849 31210 62959806
Post-traumatic stress disorder 18.50 11.71 9 497997 5242 62985774
Non-small cell lung cancer 18.48 11.71 3 498003 3592 62987424
Peripheral venous disease 18.35 11.71 194 497812 15283 62975733
Skin toxicity 18.33 11.71 7 497999 4707 62986309
Brain natriuretic peptide increased 18.27 11.71 9 497997 5204 62985812
Drooling 18.24 11.71 4 498002 3864 62987152
Drug effective for unapproved indication 18.22 11.71 63 497943 3301 62987715
Humerus fracture 18.21 11.71 26 497980 8890 62982126
Cerebellar syndrome 18.09 11.71 3 498003 3536 62987480
Antiphospholipid syndrome 18.06 11.71 42 497964 1748 62989268
Respiratory rate decreased 18.06 11.71 3 498003 3532 62987484
Limb operation 18.05 11.71 71 497935 3960 62987056
Emotional disorder 17.88 11.71 50 497956 13329 62977687
Lymphadenopathy 17.87 11.71 204 497802 38254 62952762
Inflammatory marker increased 17.84 11.71 103 497903 6736 62984280
Exposure during pregnancy 17.79 11.71 1434 496572 154113 62836903
Illness 17.77 11.71 274 497732 48785 62942231
Palmoplantar pustulosis 17.72 11.71 21 497985 492 62990524
Blood creatine increased 17.70 11.71 11 497995 5590 62985426
Middle lobe syndrome 17.67 11.71 8 497998 35 62990981
Coronary artery occlusion 17.62 11.71 23 497983 8168 62982848
Obsessive-compulsive disorder 17.59 11.71 5 498001 4055 62986961
Contraindication to medical treatment 17.54 11.71 24 497982 652 62990364
Neoplasm 17.54 11.71 19 497987 7326 62983690
Limb deformity 17.53 11.71 70 497936 3932 62987084
Nerve injury 17.50 11.71 32 497974 9914 62981102
Heparin-induced thrombocytopenia 17.49 11.71 7 497999 4575 62986441
Urticarial vasculitis 17.46 11.71 24 497982 655 62990361
Haemolytic anaemia 17.44 11.71 33 497973 10092 62980924
Appetite disorder 17.41 11.71 19 497987 7302 62983714
Maternal exposure timing unspecified 17.37 11.71 105 497901 6982 62984034
Tenosynovitis stenosans 17.35 11.71 62 497944 3302 62987714
Hepatitis cholestatic 17.32 11.71 17 497989 6861 62984155
Anaphylactoid reaction 17.25 11.71 4 498002 3719 62987297
Aortic arteriosclerosis 17.25 11.71 14 497992 6195 62984821
No adverse event 17.20 11.71 225 497781 41180 62949836
Autoimmune hepatitis 17.20 11.71 25 497981 8485 62982531
Dermatitis bullous 17.19 11.71 25 497981 8483 62982533
Gastric disorder 17.17 11.71 399 497607 36970 62954046
Rhinitis 17.10 11.71 40 497966 11326 62979690
Refusal of treatment by patient 17.09 11.71 11 497995 5486 62985530
Pathogen resistance 17.07 11.71 15 497991 6383 62984633
Pneumonia bacterial 17.06 11.71 30 497976 9435 62981581
Autoimmune disorder 17.06 11.71 208 497798 16969 62974047
General physical health deterioration 17.04 11.71 1817 496189 199585 62791431
Cerebral haematoma 16.98 11.71 4 498002 3679 62987337
Urosepsis 16.97 11.71 81 497925 18443 62972573
Spinal meningioma benign 16.90 11.71 11 497995 110 62990906
Hepatic cancer 16.89 11.71 7 497999 4480 62986536
Pre-existing condition improved 16.88 11.71 24 497982 8220 62982796
Femur fracture 16.84 11.71 438 497568 41318 62949698
Blood potassium increased 16.81 11.71 80 497926 18229 62972787
Extradural abscess 16.80 11.71 28 497978 909 62990107
Retinal haemorrhage 16.79 11.71 9 497997 4960 62986056
Loss of employment 16.76 11.71 47 497959 2197 62988819
Cornea verticillata 16.76 11.71 12 497994 142 62990874
Insurance issue 16.76 11.71 14 497992 6107 62984909
Snoring 16.74 11.71 6 498000 4196 62986820
Haemoglobin increased 16.73 11.71 4 498002 3642 62987374
Fluid intake reduced 16.70 11.71 4 498002 3637 62987379
Functional gastrointestinal disorder 16.70 11.71 72 497934 4187 62986829
Larynx irritation 16.66 11.71 11 497995 113 62990903
Tension headache 16.65 11.71 10 497996 5176 62985840
Electrocardiogram abnormal 16.63 11.71 29 497977 9150 62981866
Mitral valve incompetence 16.63 11.71 88 497918 19506 62971510
Peripheral coldness 16.60 11.71 45 497961 12120 62978896
Infection reactivation 16.59 11.71 32 497974 1167 62989849
Vitamin B12 decreased 16.56 11.71 4 498002 3616 62987400
Androgenetic alopecia 16.55 11.71 12 497994 145 62990871
West Nile viral infection 16.55 11.71 18 497988 383 62990633
Cytopenia 16.53 11.71 42 497964 11559 62979457
Infected seroma 16.52 11.71 10 497996 87 62990929
Walking aid user 16.51 11.71 142 497864 10575 62980441
C-reactive protein 16.50 11.71 79 497927 4803 62986213
Mean cell haemoglobin concentration decreased 16.50 11.71 4 498002 3608 62987408
Systemic inflammatory response syndrome 16.48 11.71 12 497994 5609 62985407
Catheter site infection 16.46 11.71 9 497997 4905 62986111
Pseudomonas infection 16.44 11.71 40 497966 11173 62979843
Paradoxical drug reaction 16.42 11.71 6 498000 4146 62986870
Neuropsychiatric lupus 16.35 11.71 13 497993 182 62990834
Coloboma 16.33 11.71 10 497996 89 62990927
Cranial nerve injury 16.32 11.71 6 498000 13 62991003
Infectious crystalline keratopathy 16.32 11.71 6 498000 13 62991003
Urine leukocyte esterase positive 16.28 11.71 4 498002 3575 62987441
Infusion site extravasation 16.24 11.71 36 497970 10390 62980626
Ventricular fibrillation 16.12 11.71 44 497962 11823 62979193
Catheterisation cardiac 16.05 11.71 8 497998 4595 62986421
Pleuritic pain 16.04 11.71 113 497893 7916 62983100
Autoimmune haemolytic anaemia 16.04 11.71 8 497998 4593 62986423
Portal hypertension 16.01 11.71 5 498001 3814 62987202
Natural killer-cell leukaemia 15.97 11.71 10 497996 93 62990923
Anaphylactic shock 15.96 11.71 114 497892 23519 62967497
Salt craving 15.95 11.71 11 497995 122 62990894
Injection site induration 15.95 11.71 30 497976 9196 62981820
Bronchitis 15.90 11.71 809 497197 124126 62866890
Cardiovascular disorder 15.89 11.71 44 497962 11768 62979248
Gingival hyperpigmentation 15.85 11.71 5 498001 5 62991011
Urine abnormality 15.84 11.71 19 497987 7000 62984016
Decubitus ulcer 15.84 11.71 37 497969 10483 62980533
Oral lichen planus 15.79 11.71 23 497983 663 62990353
Disease complication 15.79 11.71 3 498003 3206 62987810
Bacterial infection 15.76 11.71 89 497917 19410 62971606
Breast pain 15.76 11.71 28 497978 8770 62982246
Hypercholesterolaemia 15.75 11.71 245 497761 21089 62969927
Insomnia 15.68 11.71 1464 496542 213788 62777228
Formication 15.67 11.71 7 497999 4284 62986732
Dizziness postural 15.58 11.71 21 497985 7355 62983661
Adjustment disorder 15.58 11.71 3 498003 3175 62987841
Dermatitis exfoliative 15.56 11.71 12 497994 5447 62985569
Psoriasis 15.51 11.71 542 497464 86415 62904601
Photopsia 15.48 11.71 8 497998 4501 62986515
Treatment noncompliance 15.45 11.71 203 497803 37122 62953894
COVID-19 15.44 11.71 727 497279 112376 62878640
Poor quality product administered 15.43 11.71 3 498003 3153 62987863
Symptom masked 15.41 11.71 24 497982 735 62990281
Ventricular extrasystoles 15.38 11.71 44 497962 11643 62979373
Metastases to peritoneum 15.36 11.71 4 498002 3438 62987578
Blood phosphorus increased 15.35 11.71 3 498003 3142 62987874
Abortion incomplete 15.25 11.71 3 498003 3128 62987888
Increased appetite 15.21 11.71 33 497973 9597 62981419
Incorrect drug administration rate 15.21 11.71 6 498000 3956 62987060
Angina unstable 15.19 11.71 20 497986 7075 62983941
Rales 15.14 11.71 50 497956 12647 62978369
White blood cells urine positive 15.13 11.71 11 497995 5147 62985869
Gastritis erosive 15.12 11.71 15 497991 6024 62984992
Hereditary motor and sensory neuropathy 15.12 11.71 10 497996 103 62990913
Localised oedema 15.10 11.71 12 497994 5366 62985650
Retinal deposits 15.09 11.71 9 497997 76 62990940
Performance status decreased 15.09 11.71 5 498001 3673 62987343
Antinuclear antibody positive 15.07 11.71 111 497895 7888 62983128
Blood uric acid increased 15.04 11.71 12 497994 5355 62985661
Occult blood positive 15.04 11.71 5 498001 3665 62987351
Bone disorder 15.02 11.71 243 497763 21083 62969933
Tooth loss 15.01 11.71 19 497987 6837 62984179
Paronychia 14.91 11.71 13 497993 5552 62985464
Injection site bruising 14.86 11.71 235 497771 41675 62949341
Peripheral ischaemia 14.85 11.71 10 497996 4868 62986148
Blood chloride decreased 14.78 11.71 13 497993 5529 62985487
Drug level below therapeutic 14.78 11.71 10 497996 4856 62986160
Arterial occlusive disease 14.69 11.71 15 497991 5943 62985073
Heart rate decreased 14.68 11.71 260 497746 45300 62945716
Placenta accreta 14.67 11.71 13 497993 213 62990803
Choking 14.67 11.71 35 497971 9844 62981172
Cardiopulmonary failure 14.66 11.71 5 498001 3607 62987409
Pulmonary mass 14.64 11.71 254 497752 22342 62968674
Lymphoma 14.53 11.71 48 497958 12139 62978877
Adrenal insufficiency 14.49 11.71 209 497797 17706 62973310
Sluggishness 14.49 11.71 12 497994 5257 62985759
Rheumatic disorder 14.49 11.71 55 497951 3017 62987999
Central nervous system lupus 14.49 11.71 19 497987 495 62990521
Bowel movement irregularity 14.46 11.71 12 497994 5252 62985764
Staphylococcal sepsis 14.44 11.71 26 497980 8102 62982914
Adenoiditis 14.41 11.71 7 497999 37 62990979
Urine analysis abnormal 14.33 11.71 11 497995 5005 62986011
Antinuclear antibody negative 14.29 11.71 13 497993 221 62990795
Eye movement disorder 14.26 11.71 12 497994 5216 62985800
Product administered to patient of inappropriate age 14.20 11.71 4 498002 3264 62987752
Gastrointestinal sounds abnormal 14.19 11.71 7 497999 4044 62986972
Cytomegalovirus viraemia 14.18 11.71 14 497992 5635 62985381
Coombs positive haemolytic anaemia 14.18 11.71 16 497990 355 62990661
Haematocrit decreased 14.15 11.71 220 497786 39120 62951896
Gonorrhoea 14.13 11.71 10 497996 116 62990900
Decreased interest 14.11 11.71 4 498002 3250 62987766
Product monitoring error 14.09 11.71 9 497997 4507 62986509
Bursitis infective 14.09 11.71 32 497974 1311 62989705
Sensation of foreign body 14.08 11.71 10 497996 4735 62986281
Forced expiratory volume decreased 14.06 11.71 11 497995 4957 62986059
Catheter site pain 14.02 11.71 10 497996 4725 62986291
Gout 14.01 11.71 55 497951 13216 62977800
Uterine cancer 14.01 11.71 10 497996 4723 62986293
Headache 13.97 11.71 4601 493405 628640 62362376
Mycobacterial infection 13.97 11.71 38 497968 1745 62989271
Inadequate analgesia 13.96 11.71 3 498003 2940 62988076
Neutrophil percentage increased 13.96 11.71 3 498003 2940 62988076
Facial paresis 13.93 11.71 5 498001 3493 62987523
Colitis ulcerative 13.91 11.71 134 497872 25957 62965059
Skin abrasion 13.90 11.71 33 497973 9296 62981720
Overweight 13.88 11.71 6 498000 3745 62987271
Rheumatoid factor quantitative increased 13.87 11.71 5 498001 10 62991006
Pulse absent 13.86 11.71 13 497993 5361 62985655
Exposed bone in jaw 13.84 11.71 3 498003 2922 62988094
Infective tenosynovitis 13.83 11.71 15 497991 318 62990698
Monocyte count abnormal 13.83 11.71 12 497994 191 62990825
Ocular discomfort 13.82 11.71 8 497998 4225 62986791
Scleritis 13.79 11.71 70 497936 4358 62986658
Facial bones fracture 13.77 11.71 7 497999 3975 62987041
Renal pain 13.72 11.71 19 497987 6580 62984436
Ankylosing spondylitis 13.71 11.71 134 497872 10340 62980676
Fracture delayed union 13.68 11.71 46 497960 2376 62988640
Ventricular tachycardia 13.67 11.71 96 497910 19883 62971133
Confusional state 13.67 11.71 1634 496372 234746 62756270
Diaphragm muscle weakness 13.67 11.71 6 498000 24 62990992
Escherichia urinary tract infection 13.66 11.71 48 497958 11914 62979102
Micrognathia 13.64 11.71 14 497992 278 62990738
Neutrophil count abnormal 13.62 11.71 3 498003 2889 62988127
Muscle haemorrhage 13.62 11.71 4 498002 3175 62987841
Dermatitis allergic 13.59 11.71 180 497826 14968 62976048
Blood disorder 13.58 11.71 20 497986 6751 62984265
Creatinine urine abnormal 13.57 11.71 7 497999 43 62990973
Haemolysis 13.57 11.71 20 497986 6748 62984268
Cataract 13.55 11.71 562 497444 56491 62934525
Synovial disorder 13.52 11.71 41 497965 2004 62989012
Congenital osteodystrophy 13.48 11.71 6 498000 25 62990991
Double stranded DNA antibody positive 13.43 11.71 15 497991 329 62990687
Laryngeal oedema 13.42 11.71 15 497991 5703 62985313
Hepatomegaly 13.38 11.71 48 497958 11841 62979175
Anticoagulation drug level increased 13.38 11.71 12 497994 200 62990816
Spinal compression fracture 13.35 11.71 62 497944 14221 62976795
Blood glucose abnormal 13.35 11.71 26 497980 7866 62983150
Phlebitis 13.35 11.71 20 497986 6704 62984312
Polyp 13.34 11.71 19 497987 6502 62984514
Vertigo positional 13.32 11.71 3 498003 2846 62988170
Ovarian cyst 13.32 11.71 72 497934 15873 62975143
Multiple system atrophy 13.28 11.71 12 497994 202 62990814
Renal function test abnormal 13.27 11.71 6 498000 3647 62987369
Blood pressure systolic abnormal 13.25 11.71 162 497844 13224 62977792
Tooth extraction 13.24 11.71 39 497967 10225 62980791
Thyroid function test abnormal 13.24 11.71 6 498000 3641 62987375
Areflexia 13.22 11.71 4 498002 3114 62987902
Thoracic vertebral fracture 13.21 11.71 10 497996 4582 62986434
Sleep disorder due to a general medical condition 13.20 11.71 50 497956 12138 62978878
Latent tuberculosis 13.20 11.71 48 497958 2579 62988437
Supraventricular extrasystoles 13.19 11.71 10 497996 4579 62986437
Microtia 13.17 11.71 16 497990 385 62990631
Drug dose omission by device 13.12 11.71 11 497995 4790 62986226
Emphysema 13.10 11.71 43 497963 10895 62980121
Intervertebral disc compression 13.08 11.71 29 497977 1169 62989847
Gestational diabetes 13.07 11.71 29 497977 8367 62982649
Intracranial pressure increased 13.07 11.71 13 497993 5214 62985802
Iodine allergy 13.07 11.71 23 497983 781 62990235
Psychiatric symptom 13.05 11.71 13 497993 5210 62985806
Clear cell renal cell carcinoma 13.01 11.71 33 497973 1452 62989564
Dermatitis acneiform 12.99 11.71 12 497994 4984 62986032
Ovarian granulosa cell tumour 12.98 11.71 5 498001 13 62991003
Neck surgery 12.97 11.71 38 497968 1822 62989194
Mixed connective tissue disease 12.96 11.71 18 497988 496 62990520
Upper-airway cough syndrome 12.92 11.71 46 497960 11372 62979644
Humoral immune defect 12.91 11.71 13 497993 252 62990764
Endophthalmitis 12.90 11.71 6 498000 3586 62987430
Cryptococcal meningoencephalitis 12.89 11.71 9 497997 102 62990914
Short stature 12.89 11.71 21 497985 669 62990347
Malabsorption 12.87 11.71 8 497998 4064 62986952
Pleuropericarditis 12.83 11.71 13 497993 254 62990762
Blood test abnormal 12.82 11.71 71 497935 15558 62975458
Injury 12.81 11.71 700 497306 72547 62918469
Hypergammaglobulinaemia 12.77 11.71 18 497988 503 62990513
Self-medication 12.74 11.71 3 498003 2760 62988256
Hypertelorism 12.73 11.71 17 497989 451 62990565
Pneumocystis jirovecii pneumonia 12.72 11.71 79 497927 16835 62974181
Lupus enteritis 12.70 11.71 7 497999 50 62990966
Catheter site erythema 12.70 11.71 9 497997 4267 62986749
Foetal movement disorder 12.68 11.71 4 498002 4 62991012
Kidney transplant rejection 12.67 11.71 9 497997 4262 62986754
Petit mal epilepsy 12.63 11.71 7 497999 3787 62987229
Catatonia 12.56 11.71 10 497996 4467 62986549
Liver disorder 12.55 11.71 528 497478 53159 62937857
Vulvovaginal pain 12.55 11.71 3 498003 2732 62988284
Injection site pruritus 12.54 11.71 264 497742 44852 62946164
Low density lipoprotein increased 12.53 11.71 19 497987 6338 62984678
BK virus infection 12.53 11.71 5 498001 3274 62987742
Carotid artery occlusion 12.53 11.71 11 497995 4683 62986333
Azotaemia 12.52 11.71 10 497996 4461 62986555
Endocarditis 12.52 11.71 16 497990 5734 62985282
Duodenitis 12.52 11.71 7 497999 3768 62987248
Biliary dyskinesia 12.51 11.71 3 498003 2726 62988290
Oxygen saturation abnormal 12.51 11.71 6 498000 3523 62987493
Body height decreased 12.50 11.71 39 497967 10039 62980977
Venous thrombosis limb 12.50 11.71 4 498002 3004 62988012
Rotator cuff repair 12.47 11.71 41 497965 2093 62988923
Erythematotelangiectatic rosacea 12.47 11.71 5 498001 15 62991001
Neurologic neglect syndrome 12.46 11.71 3 498003 2718 62988298
Red blood cell count decreased 12.45 11.71 234 497772 40411 62950605
Trigeminal neuralgia 12.45 11.71 6 498000 3513 62987503
Pelvic fracture 12.45 11.71 58 497948 13290 62977726
Screaming 12.42 11.71 5 498001 3257 62987759
Urinary tract infection enterococcal 12.40 11.71 3 498003 2710 62988306
Odynophagia 12.37 11.71 25 497981 7461 62983555
Gastroenteritis 12.37 11.71 141 497865 26449 62964567
Ocular sarcoidosis 12.37 11.71 7 497999 53 62990963
Gangrene 12.36 11.71 18 497988 6105 62984911
Middle insomnia 12.35 11.71 54 497952 12589 62978427
Lymphocyte percentage decreased 12.35 11.71 4 498002 2981 62988035
End stage renal disease 12.26 11.71 21 497985 6672 62984344
Osteonecrosis 12.24 11.71 128 497878 24402 62966614
Nerve block 12.23 11.71 22 497984 760 62990256
Acute vestibular syndrome 12.23 11.71 5 498001 16 62991000
Hypophagia 12.22 11.71 172 497834 31087 62959929
Blood chloride increased 12.21 11.71 3 498003 2681 62988335
Renal tubular disorder 12.20 11.71 3 498003 2679 62988337
Sleep terror 12.18 11.71 3 498003 2677 62988339
Bundle branch block left 12.17 11.71 23 497983 7036 62983980
Product administration interrupted 12.12 11.71 12 497994 4824 62986192
Hepatitis fulminant 12.11 11.71 6 498000 3458 62987558
Faecal calprotectin increased 12.05 11.71 5 498001 3198 62987818
Monoplegia 12.04 11.71 5 498001 3196 62987820
Connective tissue disorder 12.01 11.71 31 497975 1379 62989637
Culture urine positive 11.99 11.71 7 497999 3680 62987336
Renal cyst 11.99 11.71 41 497965 10261 62980755
Blood thyroid stimulating hormone decreased 11.96 11.71 11 497995 4579 62986437
Granulomatous dermatitis 11.96 11.71 10 497996 151 62990865
Thrombophlebitis 11.95 11.71 10 497996 4358 62986658
Therapeutic response unexpected 11.94 11.71 92 497914 18667 62972349
Biliary obstruction 11.93 11.71 4 498002 2917 62988099
Abdominal hernia 11.93 11.71 13 497993 4999 62986017
Monocyte count increased 11.92 11.71 100 497906 7393 62983623
Anorectal discomfort 11.91 11.71 3 498003 2636 62988380
Drug-induced liver injury 11.90 11.71 406 497600 39816 62951200
Stress 11.89 11.71 419 497587 66748 62924268
Hereditary angioedema 11.87 11.71 26 497980 7536 62983480
Pulmonary haemorrhage 11.85 11.71 24 497982 7157 62983859
Varicose vein 11.84 11.71 13 497993 4982 62986034
Vulvovaginal exfoliation 11.81 11.71 4 498002 6 62991010
Vulvovaginal dryness 11.80 11.71 4 498002 2897 62988119
Tongue disorder 11.79 11.71 131 497875 10449 62980567
Visual field defect 11.77 11.71 90 497916 6471 62984545

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 3668.79 13.03 4407 68745 415117 34468662
Drug ineffective 2057.38 13.03 3510 69642 453241 34430538
Rheumatoid arthritis 1669.98 13.03 1023 72129 37215 34846564
Drug intolerance 1309.50 13.03 1046 72106 58524 34825255
Joint swelling 1308.83 13.03 1048 72104 58842 34824937
Synovitis 1138.74 13.03 566 72586 13500 34870279
Contraindicated product administered 889.18 13.03 556 72596 20925 34862854
Treatment failure 784.43 13.03 703 72449 45994 34837785
C-reactive protein abnormal 556.23 13.03 299 72853 8411 34875368
Therapeutic product effect decreased 520.74 13.03 491 72661 34252 34849527
Apparent death 500.83 13.03 212 72940 3432 34880347
Arthropathy 493.31 13.03 426 72726 26481 34857298
Electrocardiogram QT prolonged 428.61 13.03 477 72675 40475 34843304
Bone erosion 423.68 13.03 194 72958 3821 34879958
Arthralgia 393.03 13.03 1001 72151 169040 34714739
Musculoskeletal stiffness 389.28 13.03 484 72668 46196 34837583
Pain 371.82 13.03 1103 72049 203572 34680207
Red blood cell sedimentation rate abnormal 349.38 13.03 164 72988 3425 34880354
Death 317.34 13.03 224 72928 397825 34485954
Red blood cell sedimentation rate increased 309.69 13.03 209 72943 8953 34874826
Diverticulitis 307.78 13.03 287 72865 19717 34864062
Hand deformity 301.51 13.03 150 73002 3575 34880204
C-reactive protein increased 271.26 13.03 440 72712 53658 34830121
Mobility decreased 264.95 13.03 321 72831 29807 34853972
Loss of personal independence in daily activities 258.99 13.03 333 72819 32846 34850933
Drug hypersensitivity 239.84 13.03 524 72628 80005 34803774
Febrile neutropenia 230.63 13.03 14 73138 136835 34746944
Sleep disorder due to general medical condition, insomnia type 192.32 13.03 80 73072 1236 34882543
Peripheral swelling 189.27 13.03 463 72689 76078 34807701
Long QT syndrome 183.88 13.03 98 73054 2705 34881074
Impaired work ability 183.02 13.03 136 73016 6794 34876985
Rheumatoid factor negative 181.46 13.03 69 73083 830 34882949
Anaemia 176.74 13.03 138 73014 233197 34650582
Rheumatoid factor positive 175.20 13.03 63 73089 640 34883139
Therapeutic product effect incomplete 175.03 13.03 350 72802 50191 34833588
Condition aggravated 171.87 13.03 826 72326 191370 34692409
Drug ineffective for unapproved indication 164.94 13.03 225 72927 23490 34860289
Lymphoma 154.16 13.03 159 72993 12348 34871431
Constipation 151.48 13.03 49 73103 136933 34746846
Limb discomfort 148.15 13.03 147 73005 10900 34872879
Pulmonary thrombosis 147.35 13.03 123 73029 7284 34876495
Intentional product use issue 144.80 13.03 359 72793 59457 34824322
Arthritis 143.66 13.03 245 72907 31101 34852678
Knee arthroplasty 142.70 13.03 121 73031 7323 34876456
Gastrointestinal disorder 142.17 13.03 255 72897 33693 34850086
Drug tolerance decreased 141.06 13.03 73 73079 1894 34881885
Drug effective for unapproved indication 140.47 13.03 80 73072 2522 34881257
Malignant neoplasm progression 139.68 13.03 12 73140 88034 34795745
Hepatitis 138.61 13.03 208 72944 23696 34860083
Polyarthritis 137.92 13.03 97 73055 4443 34879336
Dehydration 135.94 13.03 51 73101 129918 34753861
Osteoarthritis 134.79 13.03 190 72962 20452 34863327
Psoriatic arthropathy 133.40 13.03 185 72967 19613 34864166
Vomiting 131.37 13.03 197 72955 247424 34636355
Terminal state 131.15 13.03 89 73063 3845 34879934
Anti-cyclic citrullinated peptide antibody positive 131.02 13.03 68 73084 1775 34882004
Herpes zoster 127.27 13.03 245 72907 34154 34849625
Onychoclasis 126.24 13.03 67 73085 1833 34881946
Abdominal pain 124.73 13.03 96 73056 163522 34720257
Toxicity to various agents 124.07 13.03 142 73010 200220 34683559
Rheumatoid nodule 123.60 13.03 77 73075 2870 34880909
Joint stiffness 122.90 13.03 132 73020 10741 34873038
Acute kidney injury 121.10 13.03 289 72863 304699 34579080
Bone cyst 119.42 13.03 61 73091 1539 34882240
Hypotension 118.83 13.03 175 72977 221474 34662305
Pyrexia 115.93 13.03 337 72815 332676 34551103
Decreased appetite 114.16 13.03 108 73044 166284 34717495
Product use in unapproved indication 110.64 13.03 513 72639 116986 34766793
Nodule 105.15 13.03 98 73054 6721 34877058
Diarrhoea 103.33 13.03 443 72709 389469 34494310
Acne cystic 102.12 13.03 39 73113 475 34883304
Seizure 100.21 13.03 47 73105 104810 34778969
Joint lock 99.22 13.03 50 73102 1225 34882554
Overdose 98.12 13.03 34 73118 91025 34792754
Confusional state 97.20 13.03 95 73057 144065 34739714
Pain in extremity 96.90 13.03 521 72631 125992 34757787
Drug specific antibody present 94.74 13.03 68 73084 3217 34880562
Tooth loss 93.64 13.03 72 73080 3786 34879993
Grip strength decreased 92.31 13.03 66 73086 3103 34880676
Completed suicide 89.28 13.03 47 73105 98121 34785658
Photosensitivity reaction 88.42 13.03 110 73042 10484 34873295
Joint arthroplasty 84.51 13.03 40 73112 851 34882928
Physical disability 83.65 13.03 46 73106 1353 34882426
Blood pressure diastolic abnormal 83.61 13.03 74 73078 4744 34879035
Intestinal sepsis 82.20 13.03 36 73116 635 34883144
Drug abuse 80.87 13.03 54 73098 99042 34784737
Systemic lupus erythematosus 80.69 13.03 65 73087 3659 34880120
Disability 80.34 13.03 72 73080 4693 34879086
Syncope 79.94 13.03 46 73106 91405 34792374
X-ray abnormal 79.71 13.03 32 73120 449 34883330
Foot deformity 77.37 13.03 69 73083 4468 34879311
Blood pressure systolic abnormal 77.36 13.03 65 73087 3883 34879896
Mass 77.34 13.03 89 73063 7816 34875963
Dyspnoea 76.53 13.03 469 72683 376313 34507466
Hip arthroplasty 76.15 13.03 68 73084 4411 34879368
Rhabdomyolysis 74.20 13.03 25 73127 68138 34815641
Intestinal polyp 73.07 13.03 38 73114 996 34882783
Pulmonary fibrosis 72.95 13.03 135 73017 18261 34865518
Hyperkalaemia 72.88 13.03 27 73125 69362 34814417
Inflammation 71.79 13.03 173 72979 28122 34855657
Cytology abnormal 71.06 13.03 28 73124 373 34883406
Thrombocytopenia 71.04 13.03 137 73015 156110 34727669
Gait inability 70.89 13.03 143 73009 20615 34863164
Skin ulcer 69.94 13.03 148 73004 22068 34861711
Ill-defined disorder 69.43 13.03 113 73039 13796 34869983
Blood glucose increased 68.34 13.03 27 73125 66691 34817088
Drug dependence 67.92 13.03 154 72998 24063 34859716
Alanine aminotransferase abnormal 67.74 13.03 65 73087 4623 34879156
Somnolence 66.26 13.03 81 73071 111035 34772744
Drug use disorder 66.10 13.03 61 73091 4130 34879649
Premature baby 65.56 13.03 134 73018 19499 34864280
Loss of consciousness 64.86 13.03 47 73105 82620 34801159
Platelet count decreased 64.55 13.03 94 73058 119623 34764156
Neutropenia 63.29 13.03 147 73005 156631 34727148
Joint ankylosis 63.22 13.03 40 73112 1532 34882247
Neoplasm malignant 63.12 13.03 133 73019 19772 34864007
Ascites 62.51 13.03 11 73141 46560 34837219
Plasma cell myeloma 60.83 13.03 8 73144 42029 34841750
Urinary tract infection 60.67 13.03 52 73100 84029 34799750
Lactic acidosis 60.23 13.03 3 73149 34769 34849010
Victim of child abuse 59.65 13.03 32 73120 895 34882884
Hallucination 59.43 13.03 17 73135 51481 34832298
Bladder transitional cell carcinoma 58.93 13.03 47 73105 2608 34881171
COVID-19 treatment 58.51 13.03 22 73130 256 34883523
Swelling 58.13 13.03 208 72944 42158 34841621
Coma 56.70 13.03 13 73139 45665 34838114
Localised infection 56.33 13.03 118 73034 17469 34866310
General physical health deterioration 56.11 13.03 115 73037 128154 34755625
Dizziness 56.01 13.03 251 72901 218270 34665509
Soft tissue swelling 55.94 13.03 26 73126 530 34883249
Fall 55.70 13.03 227 72925 202658 34681121
Hospitalisation 55.11 13.03 25 73127 56877 34826902
Alopecia 54.53 13.03 142 73010 24213 34859566
Arthritis bacterial 54.23 13.03 60 73092 5046 34878733
Blood creatinine increased 53.75 13.03 72 73080 94904 34788875
Renal impairment 53.13 13.03 72 73080 94441 34789338
Epistaxis 52.77 13.03 28 73124 58223 34825556
Gastrointestinal haemorrhage 52.21 13.03 65 73087 88412 34795367
Musculoskeletal pain 51.85 13.03 166 72986 31797 34851982
No adverse event 51.66 13.03 134 73018 22793 34860986
Blood pressure systolic increased 51.57 13.03 134 73018 22818 34860961
Gastric disorder 51.47 13.03 93 73059 12348 34871431
Hypertransaminasaemia 51.31 13.03 61 73091 5545 34878234
Low birth weight baby 50.46 13.03 72 73080 7833 34875946
Joint range of motion decreased 50.25 13.03 69 73083 7243 34876536
Deep vein thrombosis 49.39 13.03 268 72884 64980 34818799
Neutrophil count decreased 48.64 13.03 23 73129 51081 34832698
Seronegative arthritis 48.31 13.03 29 73123 1010 34882769
Disease progression 48.02 13.03 96 73056 107981 34775798
Skin laceration 47.35 13.03 90 73062 12419 34871360
Therapeutic response decreased 47.33 13.03 152 73000 29161 34854618
Lupus nephritis 45.65 13.03 20 73132 353 34883426
Hyponatraemia 45.47 13.03 64 73088 82627 34801152
Epidural lipomatosis 45.36 13.03 28 73124 1026 34882753
Anxiety 45.31 13.03 87 73065 99341 34784438
Cardiac failure 45.02 13.03 76 73076 91172 34792607
Cardiac arrest 44.82 13.03 83 73069 96076 34787703
Abdominal discomfort 44.77 13.03 245 72907 59590 34824189
Therapeutic product ineffective for unapproved indication 44.75 13.03 13 73139 61 34883718
Infection 43.80 13.03 333 72819 90582 34793197
Abdominal distension 43.64 13.03 35 73117 58457 34825322
Pancytopenia 43.59 13.03 83 73069 95074 34788705
Liver function test increased 43.51 13.03 95 73057 14470 34869309
Orthostatic hypotension 42.57 13.03 3 73149 25916 34857863
Foetal exposure during pregnancy 42.37 13.03 175 72977 37926 34845853
Disorientation 42.09 13.03 9 73143 33179 34850600
Malaise 42.05 13.03 223 72929 185602 34698177
Restlessness 41.71 13.03 3 73149 25479 34858300
Juvenile idiopathic arthritis 40.86 13.03 33 73119 1864 34881915
Blood pressure decreased 40.77 13.03 29 73123 51486 34832293
Prerenal failure 40.19 13.03 34 73118 2050 34881729
Disturbance in attention 39.88 13.03 4 73148 25941 34857838
Hepatic cirrhosis 39.84 13.03 102 73050 17212 34866567
Oral surgery 39.78 13.03 21 73131 568 34883211
Limb deformity 39.68 13.03 21 73131 571 34883208
Skin mass 39.21 13.03 45 73107 3940 34879839
Hepatic function abnormal 39.19 13.03 22 73130 44341 34839438
Liver injury 38.84 13.03 92 73060 14786 34868993
Immobile 38.75 13.03 36 73116 2458 34881321
Osteolysis 38.74 13.03 40 73112 3108 34880671
Joint effusion 38.73 13.03 51 73101 5142 34878637
Asthenia 38.61 13.03 328 72824 244923 34638856
Pneumonia aspiration 38.16 13.03 20 73132 41883 34841896
Unresponsive to stimuli 38.13 13.03 6 73146 27563 34856216
Tuberculosis 37.91 13.03 66 73086 8511 34875268
Hepatic enzyme increased 37.71 13.03 172 72980 38908 34844871
Red blood cell sedimentation rate 37.52 13.03 26 73126 1162 34882617
Neoplasm progression 37.41 13.03 3 73149 23297 34860482
Agitation 37.29 13.03 39 73113 57360 34826419
C-reactive protein decreased 37.26 13.03 32 73120 1970 34881809
Blood pressure fluctuation 37.25 13.03 127 73025 25122 34858657
Product use issue 37.14 13.03 243 72909 62973 34820806
Medication error 36.66 13.03 5 73147 25560 34858219
Dysphagia 36.61 13.03 46 73106 62335 34821444
Haematuria 36.06 13.03 31 73121 50035 34833744
Medical device implantation 35.83 13.03 20 73132 606 34883173
Granuloma skin 35.79 13.03 26 73126 1253 34882526
International normalised ratio increased 35.70 13.03 28 73124 47299 34836480
Dyskinesia 35.67 13.03 3 73149 22410 34861369
Hepatic enzyme abnormal 35.59 13.03 36 73116 2730 34881049
Musculoskeletal discomfort 35.55 13.03 62 73090 8006 34875773
Panniculitis 35.35 13.03 31 73121 1963 34881816
Blood urea increased 35.07 13.03 10 73142 30354 34853425
Aggression 34.89 13.03 19 73133 38945 34844834
Tenosynovitis 34.27 13.03 45 73107 4525 34879254
Dysarthria 34.12 13.03 15 73137 34767 34849012
Intentional overdose 34.02 13.03 25 73127 43649 34840130
Blood bilirubin increased 33.82 13.03 19 73133 38277 34845502
Pneumonia 33.76 13.03 545 72607 362082 34521697
Basal cell carcinoma 33.62 13.03 104 73048 19554 34864225
Food intolerance 33.14 13.03 26 73126 1408 34882371
Circulatory collapse 32.98 13.03 3 73149 21035 34862744
Metabolic acidosis 32.75 13.03 26 73126 43654 34840125
Heart block congenital 32.33 13.03 9 73143 35 34883744
Haematemesis 32.24 13.03 9 73143 27702 34856077
Flushing 31.77 13.03 14 73138 32406 34851373
Suicidal ideation 31.61 13.03 23 73129 40365 34843414
Maternal exposure before pregnancy 31.49 13.03 20 73132 771 34883008
White blood cell count increased 31.48 13.03 24 73128 41127 34842652
Bone marrow failure 31.35 13.03 11 73141 29242 34854537
Vitamin D deficiency 30.71 13.03 52 73100 6556 34877223
Cerebrovascular accident 30.70 13.03 84 73068 84727 34799052
Herpes simplex viraemia 30.47 13.03 10 73142 75 34883704
Cardiogenic shock 30.31 13.03 9 73143 26609 34857170
Blood parathyroid hormone decreased 30.31 13.03 25 73127 1455 34882324
Hyperglycaemia 30.23 13.03 23 73129 39457 34844322
Fine motor skill dysfunction 29.93 13.03 27 73125 1775 34882004
Wheezing 29.37 13.03 26 73126 41376 34842403
Lymphoedema 29.37 13.03 39 73113 3964 34879815
Cardio-respiratory arrest 29.17 13.03 44 73108 55229 34828550
Fatigue 29.11 13.03 574 72578 370079 34513700
Scleroderma renal crisis 28.75 13.03 13 73139 248 34883531
Sensitivity to weather change 28.26 13.03 25 73127 1601 34882178
Muscle spasms 28.12 13.03 73 73079 74928 34808851
Urticaria 28.10 13.03 225 72927 62152 34821627
Vision blurred 27.91 13.03 33 73119 45930 34837849
Lethargy 27.78 13.03 27 73125 41095 34842684
Respiratory arrest 27.65 13.03 12 73140 28031 34855748
Hypophagia 27.58 13.03 8 73144 24014 34859765
Maternal exposure during pregnancy 27.37 13.03 42 73110 4876 34878903
Intestinal obstruction 27.33 13.03 7 73145 22815 34860964
Suicide attempt 27.23 13.03 25 73127 39091 34844688
Incorrect dose administered 26.91 13.03 27 73125 40488 34843291
Cryopyrin associated periodic syndrome 26.60 13.03 9 73143 75 34883704
Chest pain 26.53 13.03 156 72996 126606 34757173
Atrial fibrillation 26.49 13.03 149 73003 122244 34761535
Dactylitis 26.39 13.03 19 73133 903 34882876
Immobilisation syndrome 26.23 13.03 13 73139 307 34883472
Pulmonary embolism 26.10 13.03 295 72857 89451 34794328
External auditory canal atresia 26.09 13.03 11 73141 176 34883603
Maculopathy 25.95 13.03 19 73133 927 34882852
Coronary artery disease 25.93 13.03 38 73114 48267 34835512
Acute lung injury 25.82 13.03 23 73129 1487 34882292
Depressed level of consciousness 25.75 13.03 31 73121 42810 34840969
Ventricular fibrillation 25.71 13.03 8 73144 22946 34860833
Skin injury 25.67 13.03 28 73124 2317 34881462
C-reactive protein 25.67 13.03 10 73142 129 34883650
Septic shock 25.36 13.03 72 73080 71762 34812017
Irritability 25.26 13.03 10 73142 24680 34859099
Product quality issue 25.23 13.03 3 73149 17032 34866747
Hepatic fibrosis 25.15 13.03 39 73113 4568 34879211
Shoulder operation 25.13 13.03 20 73132 1106 34882673
Subdural haematoma 24.96 13.03 6 73146 20415 34863364
Full blood count decreased 24.87 13.03 4 73148 18084 34865695
Cutaneous lupus erythematosus 24.67 13.03 17 73135 753 34883026
Oral disorder 24.65 13.03 37 73115 4212 34879567
Liver disorder 24.59 13.03 135 73017 32862 34850917
Neck mass 24.51 13.03 23 73129 1590 34882189
Osteonecrosis of jaw 24.50 13.03 4 73148 17885 34865894
Interstitial lung disease 24.43 13.03 226 72926 65056 34818723
Urinary retention 24.31 13.03 24 73128 36264 34847515
Cognitive disorder 24.25 13.03 15 73137 28678 34855101
Blood potassium increased 24.20 13.03 3 73149 16492 34867287
Thrombocytosis 24.13 13.03 36 73116 4076 34879703
Nail bed bleeding 24.02 13.03 13 73139 370 34883409
Dyspepsia 23.92 13.03 145 73007 36587 34847192
Hypokalaemia 23.92 13.03 54 73098 58160 34825619
Microcephaly 23.87 13.03 17 73135 794 34882985
Stent placement 23.65 13.03 40 73112 5038 34878741
Angioedema 23.60 13.03 26 73126 37348 34846431
Cerebral haemorrhage 23.53 13.03 23 73129 34914 34848865
Cellulitis 23.53 13.03 47 73105 52904 34830875
Mental status changes 23.49 13.03 27 73125 38056 34845723
Erectile dysfunction 23.46 13.03 7 73145 20630 34863149
PaO2/FiO2 ratio decreased 23.41 13.03 7 73145 37 34883742
Nodular regenerative hyperplasia 23.27 13.03 18 73134 955 34882824
Aspartate aminotransferase increased 23.16 13.03 69 73083 67714 34816065
Cytomegalovirus infection 23.03 13.03 13 73139 26122 34857657
Hypoglycaemia 23.01 13.03 50 73102 54590 34829189
Medium-chain acyl-coenzyme A dehydrogenase deficiency 22.81 13.03 7 73145 41 34883738
Fragile X syndrome 22.67 13.03 7 73145 42 34883737
Blood pressure diastolic increased 22.64 13.03 39 73113 4986 34878793
Abnormal behaviour 22.61 13.03 12 73140 24957 34858822
Iris coloboma 22.51 13.03 6 73146 19 34883760
Encephalitis Japanese B 22.51 13.03 6 73146 19 34883760
Glucose-6-phosphate dehydrogenase deficiency 22.50 13.03 9 73143 125 34883654
Palmar-plantar erythrodysaesthesia syndrome 22.46 13.03 4 73148 16791 34866988
Blood creatine phosphokinase increased 22.45 13.03 37 73115 44820 34838959
Retinal toxicity 22.34 13.03 13 73139 427 34883352
Retinal coloboma 22.27 13.03 6 73146 20 34883759
Diffuse idiopathic skeletal hyperostosis 22.26 13.03 7 73145 45 34883734
Anaphylactic reaction 22.06 13.03 21 73131 32280 34851499
Colitis ulcerative 21.95 13.03 4 73148 16516 34867263
Acute myocardial infarction 21.93 13.03 50 73102 53669 34830110
Myalgia 21.86 13.03 96 73056 84014 34799765
Latent tuberculosis 21.81 13.03 20 73132 1343 34882436
Hypofibrinogenaemia 21.80 13.03 22 73130 1664 34882115
Stevens-Johnson syndrome 21.78 13.03 6 73146 18633 34865146
Pulmonary toxicity 21.76 13.03 43 73109 6104 34877675
Arthrodesis 21.75 13.03 13 73139 449 34883330
Thrombosis 21.64 13.03 180 72972 50278 34833501
Rheumatoid lung 21.60 13.03 17 73135 925 34882854
Bradycardia 21.52 13.03 83 73069 75335 34808444
Therapy non-responder 21.49 13.03 148 73004 38998 34844781
Enthesopathy 21.04 13.03 36 73116 4577 34879202
Angina pectoris 20.72 13.03 21 73131 31342 34852437
Ocular toxicity 20.50 13.03 10 73142 228 34883551
Meningitis noninfective 20.39 13.03 5 73147 10 34883769
Drug withdrawal syndrome 20.34 13.03 8 73144 19826 34863953
External ear disorder 20.34 13.03 6 73146 30 34883749
Jaundice 20.32 13.03 22 73130 31860 34851919
Product dose omission issue 20.21 13.03 157 72995 119554 34764225
Ossicle disorder 20.02 13.03 6 73146 32 34883747
Gamma-glutamyltransferase increased 19.97 13.03 19 73133 29212 34854567
Oedema peripheral 19.83 13.03 158 72994 119654 34764125
Melaena 19.82 13.03 27 73125 35353 34848426
Mycobacterium fortuitum infection 19.80 13.03 9 73143 174 34883605
Trisomy 8 19.65 13.03 7 73145 69 34883710
Degenerative bone disease 19.65 13.03 7 73145 69 34883710
Pancreatitis 19.53 13.03 32 73120 38859 34844920
Therapy partial responder 19.44 13.03 54 73098 9562 34874217
Gout 19.36 13.03 8 73144 19245 34864534
Tender joint count 19.21 13.03 5 73147 14 34883765
Ataxia 19.19 13.03 3 73149 13850 34869929
Therapeutic response unexpected 18.95 13.03 54 73098 9703 34874076
Acute cutaneous lupus erythematosus 18.81 13.03 7 73145 79 34883700
Pulmonary oedema 18.79 13.03 45 73107 47484 34836295
Hepatic steatosis 18.60 13.03 82 73070 18280 34865499
Pneumatosis intestinalis 18.40 13.03 31 73121 3892 34879887
Dysgeusia 18.36 13.03 17 73135 26480 34857299
Unevaluable event 18.12 13.03 25 73127 32565 34851214
Agranulocytosis 18.08 13.03 14 73138 23807 34859972
Tooth injury 17.96 13.03 17 73135 1188 34882591
Chronic kidney disease 17.95 13.03 37 73115 41173 34842606
Neonatal lupus erythematosus 17.92 13.03 4 73148 4 34883775
Andersen-Tawil syndrome 17.92 13.03 4 73148 4 34883775
Diabetes mellitus 17.90 13.03 163 72989 46710 34837069
Peritonitis 17.80 13.03 6 73146 16359 34867420
Wrist surgery 17.77 13.03 8 73144 151 34883628
Tubulointerstitial nephritis 17.76 13.03 11 73141 21013 34862766
Haemorrhage 17.76 13.03 52 73100 51318 34832461
Hepatic failure 17.73 13.03 28 73124 34503 34849276
Liver function test 17.63 13.03 6 73146 51 34883728
Coronavirus infection 17.56 13.03 32 73120 4275 34879504
Antinuclear antibody positive 17.55 13.03 18 73134 1388 34882391
Presyncope 17.49 13.03 9 73143 19050 34864729
Visual acuity reduced 17.43 13.03 6 73146 16143 34867636
Disease recurrence 17.43 13.03 90 73062 21400 34862379
Ulcer 17.25 13.03 49 73103 8786 34874993
Urinary incontinence 17.19 13.03 9 73143 18865 34864914
Squamous cell carcinoma 17.17 13.03 58 73094 11417 34872362
Oral pustule 17.10 13.03 9 73143 242 34883537
Dyspnoea exertional 17.09 13.03 41 73111 43238 34840541
Malnutrition 17.05 13.03 3 73149 12706 34871073
Dysuria 17.02 13.03 19 73133 27133 34856646
Neutrophil Pelger-Huet anomaly present 16.96 13.03 9 73143 246 34883533
Hallucination, visual 16.93 13.03 8 73144 17783 34865996
Encephalopathy 16.87 13.03 30 73122 35289 34848490
Nervousness 16.86 13.03 3 73149 12603 34871176
Lupus pneumonitis 16.86 13.03 6 73146 59 34883720
Blood lactate dehydrogenase increased 16.84 13.03 14 73138 22976 34860803
Injection related reaction 16.77 13.03 10 73142 344 34883435
Infection reactivation 16.60 13.03 18 73134 1480 34882299
Psychotic disorder 16.58 13.03 16 73136 24436 34859343
Enzyme abnormality 16.57 13.03 9 73143 258 34883521
Cerebral infarction 16.36 13.03 20 73132 27435 34856344
Disseminated intravascular coagulation 16.33 13.03 13 73139 21803 34861976
Optic nerve operation 16.13 13.03 11 73141 479 34883300
Device related infection 16.03 13.03 8 73144 17229 34866550
Hyperhidrosis 15.90 13.03 93 73059 75599 34808180
Stress ulcer 15.87 13.03 6 73146 71 34883708
Q fever 15.75 13.03 7 73145 128 34883651
Perineal infection 15.67 13.03 12 73140 627 34883152
Bursa removal 15.65 13.03 7 73145 130 34883649
Depression 15.62 13.03 129 73023 96969 34786810
T-cell receptor gene rearrangement test 15.51 13.03 3 73149 0 34883779
Anomalous pulmonary venous connection 15.50 13.03 6 73146 76 34883703
Full blood count abnormal 15.45 13.03 10 73142 18658 34865121
Haemorrhage intracranial 15.44 13.03 7 73145 15939 34867840
Scrotal infection 15.44 13.03 12 73140 641 34883138
Double stranded DNA antibody positive 15.34 13.03 8 73144 211 34883568
Upper respiratory tract infection 15.29 13.03 120 73032 32939 34850840
Faeces discoloured 15.26 13.03 6 73146 14872 34868907
Pancreatitis acute 15.24 13.03 22 73130 28119 34855660
Heart rate increased 15.24 13.03 48 73104 46295 34837484
Hypomagnesaemia 15.16 13.03 14 73138 21837 34861942
Viral vasculitis 15.15 13.03 6 73146 81 34883698
Sedation 15.13 13.03 13 73139 20993 34862786
Cyanosis 15.12 13.03 4 73148 12760 34871019
Therapeutic product effect delayed 15.09 13.03 16 73136 1282 34882497
Clostridium difficile colitis 15.09 13.03 7 73145 15723 34868056
Neutropenic sepsis 15.06 13.03 5 73147 13762 34870017
Viral load abnormal 15.02 13.03 6 73146 83 34883696
Gastric ulcer 14.95 13.03 7 73145 15643 34868136
Metastases to liver 14.88 13.03 5 73147 13658 34870121
Face oedema 14.85 13.03 3 73149 11513 34872266
Myocardial ischaemia 14.85 13.03 9 73143 17399 34866380
Haemorrhoids 14.75 13.03 6 73146 14569 34869210
Tuberculin test positive 14.67 13.03 15 73137 1152 34882627
Ankle deformity 14.62 13.03 8 73144 233 34883546
Lupus-like syndrome 14.59 13.03 23 73129 2733 34881046
Speech sound disorder 14.57 13.03 7 73145 154 34883625
Cytokine storm 14.55 13.03 12 73140 698 34883081
Retro-orbital neoplasm 14.49 13.03 4 73148 15 34883764
Neutrophil count increased 14.44 13.03 9 73143 17137 34866642
Pneumocystis jirovecii pneumonia 14.44 13.03 12 73140 19698 34864081
Blood sodium decreased 14.44 13.03 8 73144 16243 34867536
Empyema 14.43 13.03 25 73127 3211 34880568
Tachycardia 14.38 13.03 111 73041 84661 34799118
Fracture 14.38 13.03 39 73113 6810 34876969
Oxygen saturation decreased 14.34 13.03 174 72978 53644 34830135
Trigger finger 14.31 13.03 13 73139 862 34882917
Blood potassium decreased 14.28 13.03 10 73142 17905 34865874
Follicular lymphoma 14.25 13.03 7 73145 162 34883617
Mental disorder 14.23 13.03 7 73145 15202 34868577
Generalised tonic-clonic seizure 14.19 13.03 14 73138 21160 34862619
Memory impairment 14.15 13.03 45 73107 43273 34840506
Aspiration 14.11 13.03 4 73148 12190 34871589
Hypoalbuminaemia 14.07 13.03 4 73148 12170 34871609
Lymphocyte count decreased 13.99 13.03 16 73136 22606 34861173
Ophthalmic herpes zoster 13.90 13.03 13 73139 895 34882884
Tendon disorder 13.86 13.03 23 73129 2852 34880927
Transient ischaemic attack 13.60 13.03 23 73129 27590 34856189
Antiphospholipid syndrome 13.60 13.03 10 73142 491 34883288
Blood alkaline phosphatase increased 13.56 13.03 28 73124 31147 34852632
Acute respiratory distress syndrome 13.56 13.03 97 73055 25872 34857907
Acute myeloid leukaemia 13.53 13.03 11 73141 18259 34865520
Neurological examination abnormal 13.50 13.03 8 73144 272 34883507
Herpes dermatitis 13.47 13.03 5 73147 56 34883723
Ileus 13.43 13.03 9 73143 16490 34867289
Mucosal inflammation 13.42 13.03 39 73113 38583 34845196
Accidental exposure to product 13.40 13.03 5 73147 12797 34870982
Olfactory nerve disorder 13.40 13.03 4 73148 21 34883758
Prostatic specific antigen increased 13.37 13.03 7 73145 14673 34869106
Treatment noncompliance 13.30 13.03 24 73128 28076 34855703
Altered state of consciousness 13.30 13.03 17 73135 22876 34860903
Product administration error 13.19 13.03 9 73143 16335 34867444
Tendon pain 13.17 13.03 23 73129 2972 34880807
Hypocalcaemia 13.14 13.03 19 73133 24270 34859509
Subarachnoid haemorrhage 13.12 13.03 5 73147 12630 34871149
Joint space narrowing 13.10 13.03 7 73145 194 34883585
Status epilepticus 13.08 13.03 5 73147 12609 34871170

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 6283.01 10.99 16120 411860 1064793 78251615
Drug intolerance 5525.74 10.99 6933 421047 257186 79059222
Joint swelling 4074.15 10.99 6272 421708 282374 79034034
Synovitis 4045.54 10.99 4499 423481 146235 79170173
Contraindicated product administered 3545.08 10.99 4295 423685 153243 79163165
Rheumatoid arthritis 3208.60 10.99 4720 423260 203750 79112658
Treatment failure 3178.86 10.99 4233 423747 166253 79150155
Off label use 2629.34 10.99 10694 417286 896521 78419887
Therapeutic product effect decreased 2487.66 10.99 3688 424292 160175 79156233
Arthropathy 2438.38 10.99 3809 424171 173302 79143106
Arthralgia 1761.19 10.99 6881 421099 564922 78751486
Systemic lupus erythematosus 1725.43 10.99 2648 425332 118501 79197907
Hand deformity 1559.88 10.99 2328 425652 101591 79214817
Death 1504.97 10.99 581 427399 565933 78750475
C-reactive protein abnormal 1477.71 10.99 1548 426432 46819 79269589
Pain 1413.72 10.99 7465 420515 696337 78620071
Musculoskeletal stiffness 1393.26 10.99 2970 425010 172038 79144370
Pemphigus 1297.39 10.99 2090 425890 97492 79218916
Swelling 1275.46 10.99 3267 424713 213444 79102964
Rheumatoid factor positive 1244.44 10.99 1570 426410 58269 79258139
Anti-cyclic citrullinated peptide antibody positive 1233.74 10.99 1853 426127 81290 79235118
Abdominal discomfort 1190.02 10.99 3493 424487 247234 79069174
Red blood cell sedimentation rate abnormal 1175.19 10.99 943 427037 20020 79296388
Acute kidney injury 1163.38 10.99 673 427307 518731 78797677
Glossodynia 1113.37 10.99 1993 425987 101344 79215064
Alopecia 1088.00 10.99 3213 424767 228142 79088266
Peripheral swelling 1082.74 10.99 3544 424436 266073 79050335
Hepatic enzyme increased 1037.06 10.99 2717 425263 179893 79136515
Drug hypersensitivity 1003.93 10.99 3703 424277 295213 79021195
Red blood cell sedimentation rate increased 921.32 10.99 1184 426796 44758 79271650
Pericarditis 878.87 10.99 1812 426168 102424 79213984
Completed suicide 866.62 10.99 140 427840 245627 79070781
Febrile neutropenia 862.38 10.99 111 427869 230888 79085520
Anaemia 858.78 10.99 679 427301 444336 78872072
Hypersensitivity 790.69 10.99 3140 424840 259099 79057309
Condition aggravated 770.12 10.99 4958 423022 496166 78820242
Therapeutic product effect incomplete 762.77 10.99 2067 425913 139578 79176830
C-reactive protein increased 749.73 10.99 1937 426043 127090 79189318
Wound 747.29 10.99 1813 426167 114366 79202042
Loss of personal independence in daily activities 717.46 10.99 1654 426326 100926 79215482
Hypotension 696.24 10.99 803 427177 439514 78876894
Constipation 680.83 10.99 334 427646 282716 79033692
Gastrointestinal disorder 676.69 10.99 1802 426178 120403 79196005
Helicobacter infection 668.36 10.99 1279 426701 68425 79247983
Dehydration 650.20 10.99 259 427721 247928 79068480
Duodenal ulcer perforation 628.79 10.99 1210 426770 65001 79251407
Discomfort 612.13 10.99 1768 426212 123849 79192559
Toxicity to various agents 609.57 10.99 823 427157 420717 78895691
Psoriatic arthropathy 601.75 10.99 1308 426672 76691 79239717
Malignant neoplasm progression 601.49 10.99 31 427949 135959 79180449
Infusion related reaction 593.07 10.99 2628 425352 227609 79088799
Drug abuse 572.58 10.99 93 427887 162598 79153810
Arthritis 556.92 10.99 1614 426366 113266 79203142
Infection 552.42 10.99 2664 425316 239048 79077360
Maternal exposure during pregnancy 548.16 10.99 1796 426184 134742 79181666
Sleep disorder due to general medical condition, insomnia type 536.81 10.99 892 427088 42664 79273744
Bone erosion 533.77 10.99 565 427415 17282 79299126
Muscle injury 528.29 10.99 941 427039 47620 79268788
Hyponatraemia 518.49 10.99 155 427825 177693 79138715
Folliculitis 511.08 10.99 1000 426980 54380 79262028
Mobility decreased 503.86 10.99 1622 426358 120553 79195855
Inflammation 503.30 10.99 1367 426613 92386 79224022
Irritable bowel syndrome 502.18 10.99 1063 426917 61178 79255230
Osteoarthritis 489.81 10.99 1294 426686 86015 79230393
Rash 486.22 10.99 4988 422992 573370 78743038
Product use issue 480.34 10.99 2314 425666 207508 79108900
Neutropenia 479.33 10.99 502 427478 287208 79029200
Seizure 473.67 10.99 210 427770 188624 79127784
Thrombocytopenia 463.42 10.99 444 427536 264815 79051593
Impaired healing 458.46 10.99 1266 426714 86389 79230019
Retinal toxicity 449.31 10.99 196 427784 1215 79315193
Ill-defined disorder 444.90 10.99 1048 426932 64827 79251581
Somnolence 442.51 10.99 379 427601 238602 79077806
Fibromyalgia 425.22 10.99 1015 426965 63325 79253083
Lower respiratory tract infection 412.13 10.99 1576 426404 127644 79188764
Sinusitis 399.35 10.99 2088 425892 193413 79122995
Atrial fibrillation 395.00 10.99 291 427689 197595 79118813
Hyperkalaemia 392.31 10.99 70 427910 114328 79202080
Tremor 386.08 10.99 216 427764 169867 79146541
Gastrointestinal haemorrhage 380.42 10.99 158 427822 147561 79168847
Blister 368.59 10.99 1442 426538 118034 79198374
Rheumatoid nodule 367.81 10.99 461 427519 16977 79299431
Dyspnoea 366.28 10.99 2898 425082 854127 78462281
Rhabdomyolysis 364.94 10.99 58 427922 103073 79213335
Bradycardia 358.86 10.99 139 427841 135418 79180990
Knee arthroplasty 357.39 10.99 746 427234 42502 79273906
Overdose 353.46 10.99 282 427698 183924 79132484
Platelet count decreased 351.50 10.99 316 427664 194348 79122060
Sepsis 329.76 10.99 588 427392 268840 79047568
Joint range of motion decreased 319.27 10.99 611 427369 32671 79283737
Depressed level of consciousness 318.96 10.99 65 427915 96587 79219821
Grip strength decreased 312.18 10.99 479 427501 21390 79295018
Cardio-respiratory arrest 311.78 10.99 97 427883 108413 79207995
Coma 311.48 10.99 78 427902 100571 79215837
Neutrophil count decreased 308.39 10.99 64 427916 93895 79222513
Disease progression 305.37 10.99 323 427657 184039 79132369
Nasopharyngitis 303.94 10.99 2367 425613 251514 79064894
Impaired work ability 303.63 10.99 447 427533 19234 79297174
Renal failure 301.68 10.99 381 427599 200587 79115821
Cardiac arrest 300.48 10.99 288 427692 171808 79144600
Hip arthroplasty 300.39 10.99 621 427359 35135 79281273
Musculoskeletal disorder 295.28 10.99 462 427518 20986 79295422
Lactic acidosis 290.39 10.99 23 427957 70336 79246072
Drug interaction 289.31 10.99 1196 426784 413987 78902421
Drug tolerance decreased 288.03 10.99 352 427628 12626 79303782
Syncope 286.60 10.99 324 427656 179125 79137283
Musculoskeletal pain 285.92 10.99 1198 426782 101156 79215252
Tachycardia 281.70 10.99 323 427657 177445 79138963
Pulmonary fibrosis 278.69 10.99 684 427296 43428 79272980
Disability 277.44 10.99 398 427582 16722 79299686
Fall 273.14 10.99 1519 426461 486110 78830298
Joint stiffness 271.76 10.99 646 427334 40184 79276224
Hallucination 270.11 10.99 64 427916 85681 79230727
Agitation 269.33 10.99 99 427881 99616 79216792
Cardiac failure 265.82 10.99 263 427717 154579 79161829
Metabolic acidosis 263.15 10.99 60 427920 82469 79233939
Rheumatic fever 246.21 10.99 501 427479 28024 79288384
Cerebrovascular accident 246.20 10.99 282 427698 155010 79161398
Epistaxis 245.34 10.99 147 427833 111368 79205040
Intentional product use issue 244.28 10.99 1524 426456 150588 79165820
Pneumonia 237.54 10.99 2332 425648 657914 78658494
Abdominal pain 236.77 10.99 1180 426800 388389 78928019
Blood parathyroid hormone decreased 235.82 10.99 287 427693 10249 79306159
International normalised ratio increased 234.11 10.99 81 427899 84640 79231768
White blood cell count decreased 233.82 10.99 407 427573 187881 79128527
Therapeutic response decreased 232.76 10.99 839 427141 66014 79250394
Panniculitis 231.09 10.99 308 427672 12063 79304345
Granuloma skin 230.31 10.99 265 427715 8909 79307499
Anxiety 222.90 10.99 642 427338 247870 79068538
Nodule 221.60 10.99 423 427557 22571 79293837
Adverse event 220.20 10.99 768 427212 59446 79256962
Neoplasm progression 218.69 10.99 15 427965 51667 79264741
Blood cholesterol increased 217.70 10.99 959 427021 82761 79233647
Cognitive disorder 216.72 10.99 54 427926 69872 79246536
Decreased appetite 215.65 10.99 1024 426956 341394 78975014
Cardiac failure congestive 213.61 10.99 270 427710 142132 79174276
Pancytopenia 212.48 10.99 351 427629 165394 79151014
Balance disorder 209.61 10.99 136 427844 98721 79217687
Retinopathy 207.38 10.99 170 427810 3721 79312687
Intentional overdose 207.24 10.99 159 427821 105801 79210607
Dizziness 204.35 10.99 1824 426156 524617 78791791
Renal impairment 204.25 10.99 332 427648 157451 79158957
Product dose omission issue 203.83 10.99 665 427315 246872 79069536
Blood glucose increased 203.46 10.99 190 427790 114785 79201623
Hyperhidrosis 202.51 10.99 312 427668 151180 79165228
Respiratory arrest 202.15 10.99 33 427947 57517 79258891
Swollen joint count increased 201.82 10.99 406 427574 22521 79293887
Stomatitis 201.49 10.99 1414 426566 145343 79171065
Polyarthritis 201.15 10.99 286 427694 11916 79304492
Pyrexia 200.84 10.99 2506 425474 676203 78640205
Lupus nephritis 200.53 10.99 150 427830 2858 79313550
Disturbance in attention 200.47 10.99 20 427960 50781 79265627
Herpes zoster 198.06 10.99 1006 426974 92077 79224331
Pneumonia aspiration 197.55 10.99 57 427923 66910 79249498
Pulmonary embolism 196.34 10.99 390 427590 171264 79145144
Hypoglycaemia 194.21 10.99 156 427824 101438 79214970
Deformity 193.18 10.99 248 427732 9357 79307051
Foot deformity 192.75 10.99 410 427570 23664 79292744
Multiple organ dysfunction syndrome 192.06 10.99 217 427763 120029 79196379
Dysphagia 191.19 10.99 224 427756 121912 79194496
Hepatic function abnormal 190.09 10.99 77 427903 73030 79243378
Suicide attempt 190.02 10.99 104 427876 82828 79233580
Multiple sclerosis relapse 189.84 10.99 16 427964 46517 79269891
Blood bilirubin increased 188.82 10.99 60 427920 66172 79250236
Respiratory failure 188.61 10.99 433 427547 180478 79135930
Joint effusion 188.10 10.99 343 427637 17671 79298737
Disorientation 187.84 10.99 52 427928 62724 79253684
Ascites 187.84 10.99 85 427895 75477 79240931
Melaena 186.81 10.99 48 427932 60842 79255566
Tenosynovitis 184.21 10.99 313 427667 15241 79301167
Plasma cell myeloma 183.84 10.99 32 427948 53227 79263181
Hypoxia 183.41 10.99 170 427810 103073 79213335
Vomiting 180.62 10.99 2503 425477 663325 78653083
Sedation 179.53 10.99 31 427949 51864 79264544
Acute myocardial infarction 178.85 10.99 95 427885 76941 79239467
Cytokine release syndrome 177.75 10.99 3 427977 35995 79280413
Oedema peripheral 175.35 10.99 727 427253 251561 79064847
Osteoporosis 174.04 10.99 662 427318 53450 79262958
Unresponsive to stimuli 173.04 10.99 43 427937 55745 79260663
Encephalopathy 171.98 10.99 73 427907 67324 79249084
Hyperglycaemia 171.92 10.99 81 427899 70254 79246154
Maculopathy 171.00 10.99 133 427847 2692 79313716
Joint injury 170.14 10.99 459 427521 30876 79285532
Urinary tract infection 169.22 10.99 827 427153 273685 79042723
Cerebral haemorrhage 168.45 10.99 50 427930 57623 79258785
Blood creatinine increased 167.44 10.99 364 427616 154693 79161715
Dysarthria 166.64 10.99 77 427903 67545 79248863
Blood pressure decreased 166.04 10.99 173 427807 99293 79217115
Restlessness 162.54 10.99 27 427953 46465 79269943
Haemoglobin decreased 158.14 10.99 634 427346 221485 79094923
Pain in extremity 154.63 10.99 2782 425198 361756 78954652
Asthenia 153.52 10.99 1883 426097 509806 78806602
Dyskinesia 152.16 10.99 28 427952 44745 79271663
Urinary retention 151.60 10.99 57 427923 56573 79259835
Adverse drug reaction 151.49 10.99 732 427248 65660 79250748
Pulmonary oedema 151.30 10.99 150 427830 88104 79228304
Jaundice 150.89 10.99 49 427931 53300 79263108
Accidental overdose 150.04 10.99 18 427962 39563 79276845
Sopor 147.58 10.99 7 427973 33003 79283405
Diarrhoea 147.38 10.99 3601 424379 876888 78439520
Coronary artery disease 147.27 10.99 84 427896 65390 79251018
Pleural effusion 147.13 10.99 353 427627 144909 79171499
Fine motor skill dysfunction 146.86 10.99 162 427818 5195 79311213
Joint destruction 146.80 10.99 170 427810 5755 79310653
Neuropathy peripheral 145.82 10.99 340 427640 140965 79175443
Rheumatoid factor negative 145.15 10.99 86 427894 1087 79315321
Palmar-plantar erythrodysaesthesia syndrome 145.05 10.99 8 427972 33126 79283282
Blood urea increased 144.89 10.99 41 427939 48749 79267659
Aggression 143.77 10.99 47 427933 50911 79265497
Electrocardiogram QT prolonged 142.78 10.99 902 427078 89484 79226924
Finger deformity 142.55 10.99 188 427792 7286 79309122
Apparent death 141.95 10.99 120 427860 2745 79313663
Mental status changes 140.73 10.99 93 427887 66866 79249542
Haematuria 140.15 10.99 99 427881 68737 79247671
Hypomagnesaemia 140.09 10.99 39 427941 46872 79269536
Hepatic failure 139.88 10.99 77 427903 61135 79255273
Ulcer 138.31 10.99 414 427566 29558 79286850
Loss of consciousness 138.30 10.99 451 427529 167492 79148916
Rectal haemorrhage 136.26 10.99 125 427855 76175 79240233
Orthostatic hypotension 133.73 10.99 67 427913 56097 79260311
Myalgia 132.04 10.99 530 427450 185111 79131297
Serotonin syndrome 131.57 10.99 39 427941 44988 79271420
Contusion 130.47 10.99 1296 426684 147480 79168928
Vision blurred 130.41 10.99 230 427750 105668 79210740
Long QT syndrome 129.69 10.99 160 427820 5795 79310613
Sciatica 129.57 10.99 433 427547 32789 79283619
Myocardial infarction 129.50 10.99 528 427452 183601 79132807
Haemorrhage 129.23 10.99 180 427800 90938 79225470
Exposure during pregnancy 128.71 10.99 957 427023 100175 79216233
Diabetic ketoacidosis 128.16 10.99 16 427964 34106 79282302
Bone marrow failure 127.79 10.99 57 427923 51050 79265358
Abnormal behaviour 127.66 10.99 21 427959 36400 79280008
Physical disability 127.38 10.99 120 427860 3178 79313230
Lethargy 127.30 10.99 149 427831 81143 79235265
Therapy non-responder 126.41 10.99 889 427091 91416 79224992
X-ray abnormal 126.30 10.99 156 427824 5657 79310751
Bone density decreased 124.28 10.99 242 427738 13105 79303303
Irritability 123.24 10.99 34 427946 41110 79275298
Upper gastrointestinal haemorrhage 122.45 10.99 35 427945 41345 79275063
Wrong technique in product usage process 121.60 10.99 130 427850 73745 79242663
Elbow deformity 121.03 10.99 85 427895 1462 79314946
Chest pain 120.17 10.99 954 427026 281350 79035058
Respiratory distress 119.96 10.99 83 427897 58256 79258152
Drug withdrawal syndrome 119.52 10.99 21 427959 34697 79281711
Blood calcium decreased 119.31 10.99 15 427965 31804 79284604
Haematemesis 119.05 10.99 66 427914 52198 79264210
Tuberculin test positive 118.43 10.99 117 427863 3291 79313117
Liver injury 118.40 10.99 609 427371 56005 79260403
Neurotoxicity 117.96 10.99 17 427963 32501 79283907
Rheumatoid lung 117.46 10.99 129 427851 4116 79312292
Diverticulitis 116.96 10.99 523 427457 45413 79270995
Skin necrosis 116.92 10.99 283 427697 17804 79298604
Circulatory collapse 116.88 10.99 29 427951 37639 79278769
Seronegative arthritis 116.88 10.99 135 427845 4557 79311851
SLE arthritis 116.46 10.99 59 427921 534 79315874
Altered state of consciousness 115.81 10.99 45 427935 43777 79272631
Tubulointerstitial nephritis 115.65 10.99 31 427949 38204 79278204
Glaucoma 114.94 10.99 297 427683 19464 79296944
Generalised tonic-clonic seizure 112.93 10.99 47 427933 43863 79272545
Night sweats 112.17 10.99 565 427415 51530 79264878
Osteonecrosis of jaw 111.60 10.99 46 427934 43180 79273228
Intentional product misuse 111.56 10.99 213 427767 94952 79221456
Mucosal inflammation 111.55 10.99 145 427835 75435 79240973
Drug effective for unapproved indication 111.46 10.99 149 427831 5852 79310556
Tumour lysis syndrome 110.62 10.99 4 427976 23935 79292473
Joint laxity 109.66 10.99 95 427885 2249 79314159
Colitis 108.85 10.99 140 427840 73167 79243241
Neuroleptic malignant syndrome 108.34 10.99 11 427969 27548 79288860
Human antichimeric antibody positive 107.54 10.99 81 427899 1560 79314848
Muscle spasms 106.67 10.99 528 427452 174202 79142206
Hypokalaemia 106.39 10.99 405 427575 143635 79172773
Spinal stenosis 106.31 10.99 251 427729 15540 79300868
Type 2 diabetes mellitus 106.22 10.99 595 427385 56527 79259881
Renal phospholipidosis 106.06 10.99 35 427945 83 79316325
Blood creatine phosphokinase increased 105.80 10.99 119 427861 65971 79250437
Oral mucosal exfoliation 105.62 10.99 77 427903 1408 79315000
Shoulder arthroplasty 105.47 10.99 108 427872 3174 79313234
Hepatitis 104.64 10.99 582 427398 55145 79261263
Blood alkaline phosphatase increased 103.71 10.99 113 427867 63551 79252857
Metastases to bone 103.61 10.99 7 427973 24420 79291988
Neutropenic sepsis 103.35 10.99 12 427968 27052 79289356
Bone cyst 103.20 10.99 109 427871 3324 79313084
Suicidal ideation 103.15 10.99 156 427824 76184 79240224
Lymphocyte count decreased 103.05 10.99 63 427917 47226 79269182
Dysuria 102.77 10.99 74 427906 50877 79265531
Chills 102.59 10.99 476 427504 159758 79156650
Sleep disorder 102.42 10.99 799 427181 84878 79231530
Dysgeusia 101.70 10.99 94 427886 57083 79259325
Pallor 100.60 10.99 73 427907 49989 79266419
Haematoma 99.92 10.99 80 427900 52115 79264293
Fluid retention 99.90 10.99 137 427843 69672 79246736
Body height below normal 99.69 10.99 85 427895 1968 79314440
Cerebral infarction 99.33 10.99 61 427919 45615 79270793
Deep vein thrombosis 99.33 10.99 325 427655 120594 79195814
Abdominal distension 98.70 10.99 321 427659 119329 79197079
Epilepsy 98.40 10.99 48 427932 40812 79275596
Acute myeloid leukaemia 97.36 10.99 23 427957 30862 79285546
Red blood cell sedimentation rate 97.03 10.99 134 427846 5431 79310977
Liver function test increased 96.91 10.99 447 427533 39326 79277082
Cardiogenic shock 96.82 10.99 52 427928 41862 79274546
Cholelithiasis 96.77 10.99 84 427896 52580 79263828
Acute respiratory failure 96.64 10.99 106 427874 59435 79256973
Chronic kidney disease 96.52 10.99 128 427852 66026 79250382
Emotional distress 96.19 10.99 47 427933 39922 79276486
Status epilepticus 95.88 10.99 11 427969 25030 79291378
Musculoskeletal deformity 95.80 10.99 74 427906 1482 79314926
Wrist deformity 95.42 10.99 84 427896 2033 79314375
Bone pain 95.24 10.99 95 427885 55647 79260761
Dislocation of vertebra 95.20 10.99 160 427820 7720 79308688
Chest discomfort 94.46 10.99 400 427580 137644 79178764
Subdural haematoma 94.11 10.99 26 427954 31408 79285000
Intentional self-injury 93.06 10.99 29 427951 32390 79284018
Device expulsion 92.70 10.99 14 427966 25847 79290561
Hallucination, visual 92.66 10.99 30 427950 32699 79283709
Transient ischaemic attack 92.12 10.99 88 427892 52607 79263801
Arrhythmia 92.02 10.99 116 427864 61156 79255252
Haematochezia 91.92 10.99 209 427771 87436 79228972
Aphasia 91.51 10.99 70 427910 46662 79269746
Metastases to liver 91.42 10.99 20 427960 28294 79288114
Breast cancer stage III 91.29 10.99 178 427802 9648 79306760
Small intestinal obstruction 90.66 10.99 18 427962 27254 79289154
Fatigue 90.41 10.99 5963 422017 923764 78392644
Palpitations 90.30 10.99 361 427619 126249 79190159
Skin ulcer 90.27 10.99 548 427432 53602 79262806
Cytomegalovirus infection 89.92 10.99 59 427921 42585 79273823
Disseminated intravascular coagulation 89.57 10.99 40 427940 35802 79280606
Angioedema 89.28 10.99 170 427810 75865 79240543
Dry skin 88.95 10.99 142 427838 67853 79248555
Drug ineffective for unapproved indication 88.27 10.99 523 427457 50715 79265693
Gamma-glutamyltransferase increased 88.02 10.99 98 427882 54582 79261826
Surgical failure 87.86 10.99 56 427924 813 79315595
Muscle twitching 87.41 10.99 14 427966 24750 79291658
Eye disorder 86.77 10.99 300 427680 23112 79293296
Hypophosphataemia 86.57 10.99 5 427975 19908 79296500
Gastric disorder 86.30 10.99 414 427566 37019 79279389
Tachypnoea 86.27 10.99 32 427948 32031 79284377
Joint arthroplasty 85.95 10.99 89 427891 2651 79313757
Clostridium difficile colitis 85.56 10.99 33 427947 32250 79284158
Haemoptysis 85.17 10.99 105 427875 55894 79260514
Vertigo 85.08 10.99 150 427830 68932 79247476
Poisoning deliberate 84.14 10.99 4 427976 18824 79297584
Flatulence 83.66 10.99 64 427916 42660 79273748
Loose body in joint 82.83 10.99 63 427917 1232 79315176
Hyperthyroidism 82.00 10.99 11 427969 22198 79294210
Enthesopathy 81.96 10.99 188 427792 11420 79304988
Incorrect dose administered 81.77 10.99 181 427799 76449 79239959
Hospitalisation 81.10 10.99 248 427732 93988 79222420
Adverse reaction 80.85 10.99 164 427816 9150 79307258
Angina pectoris 80.80 10.99 95 427885 51637 79264771
Drug use disorder 80.72 10.99 157 427823 8494 79307914
Arthrodesis 80.63 10.99 81 427899 2326 79314082
Full blood count abnormal 80.06 10.99 60 427920 40414 79275994
Device related infection 80.02 10.99 42 427938 34252 79282156
Electrolyte imbalance 79.50 10.99 33 427947 30848 79285560
Colitis microscopic 78.93 10.99 177 427803 10591 79305817
Product administration error 78.86 10.99 36 427944 31810 79284598
Blood lactate dehydrogenase increased 78.86 10.99 57 427923 39113 79277295
Hypervolaemia 78.54 10.99 68 427912 42622 79273786
Gait inability 78.07 10.99 563 427417 58354 79258054
Extrapyramidal disorder 77.45 10.99 14 427966 22665 79293743
Withdrawal syndrome 77.12 10.99 24 427956 26830 79289578
Urinary incontinence 76.69 10.99 64 427916 40845 79275563
Swollen tongue 75.70 10.99 70 427910 42500 79273908
Pancreatitis acute 75.45 10.99 93 427887 49511 79266897
Full blood count decreased 75.19 10.99 25 427955 26794 79289614
Gastritis 75.10 10.99 88 427892 47905 79268503
Anti-cyclic citrullinated peptide antibody 74.97 10.99 122 427858 5730 79310678
Chronic obstructive pulmonary disease 74.80 10.99 223 427757 85196 79231212
Inappropriate antidiuretic hormone secretion 74.70 10.99 24 427956 26289 79290119
Ileus 74.25 10.99 24 427956 26187 79290221
Gastrooesophageal reflux disease 73.84 10.99 298 427682 103948 79212460
Investigation abnormal 73.79 10.99 72 427908 1994 79314414
Myoclonus 73.76 10.99 28 427952 27632 79288776
Subarachnoid haemorrhage 73.68 10.99 20 427960 24445 79291963
Dyspnoea exertional 73.62 10.99 231 427749 86842 79229566
Blood iron abnormal 73.43 10.99 60 427920 1307 79315101
Flushing 73.35 10.99 236 427744 88032 79228376
Paranoia 73.25 10.99 9 427971 19423 79296985
Device dislocation 73.18 10.99 24 427956 25946 79290462
Cough 72.81 10.99 1459 426521 365330 78951078
Intestinal obstruction 72.71 10.99 74 427906 42946 79273462
Bursitis 72.46 10.99 382 427598 35462 79280946
Epicondylitis 72.42 10.99 73 427907 2105 79314303
Ischaemic stroke 72.38 10.99 44 427936 33087 79283321
Onychomadesis 72.26 10.99 113 427867 5129 79311279
Weight increased 72.24 10.99 1975 426005 275411 79040997
Poisoning 71.84 10.99 23 427957 25249 79291159
Multiple fractures 71.67 10.99 143 427837 7883 79308525
Cyanosis 71.43 10.99 23 427957 25159 79291249
Sensitivity to weather change 71.41 10.99 143 427837 7904 79308504
Synovial cyst 71.06 10.99 163 427817 9902 79306506
Cholestasis 70.86 10.99 106 427874 52003 79264405
Myelosuppression 70.78 10.99 67 427913 40229 79276179
Wheelchair user 70.77 10.99 122 427858 6010 79310398
Haemorrhage intracranial 70.71 10.99 26 427954 26167 79290241
Drug eruption 70.32 10.99 440 427540 43495 79272913
Ear pain 69.71 10.99 355 427625 32514 79283894
Hepatic enzyme abnormal 69.56 10.99 139 427841 7671 79308737
Myocardial ischaemia 69.45 10.99 25 427955 25494 79290914
Intestinal sepsis 69.41 10.99 49 427931 850 79315558
Cardiac disorder 68.79 10.99 157 427823 65600 79250808
Confusional state 68.60 10.99 1247 426733 316750 78999658
Obstructive airways disorder 68.42 10.99 42 427938 31417 79284991
Pancreatitis 68.33 10.99 168 427812 68407 79248001
Blood pressure systolic abnormal 68.32 10.99 226 427754 17021 79299387
Hypophagia 68.01 10.99 86 427894 45281 79271127
Basal cell carcinoma 67.95 10.99 387 427593 36988 79279420
Blood potassium decreased 67.84 10.99 90 427890 46422 79269986
Presyncope 67.83 10.99 72 427908 40982 79275426
Hypothermia 67.74 10.99 19 427961 22727 79293681
Lupus-like syndrome 67.36 10.99 195 427785 13662 79302746
Paraesthesia 66.84 10.99 614 427366 175709 79140699
Onychomycosis 66.48 10.99 141 427839 8120 79308288
Neoplasm malignant 65.68 10.99 341 427639 31469 79284939
Miosis 65.60 10.99 5 427975 15784 79300624
Terminal state 65.47 10.99 104 427876 4785 79311623
Coordination abnormal 65.30 10.99 8 427972 17304 79299104
COVID-19 treatment 64.89 10.99 37 427943 433 79315975
Psychotic disorder 64.69 10.99 76 427904 41326 79275082
Septic shock 64.52 10.99 390 427590 122411 79193997
Alanine aminotransferase abnormal 64.15 10.99 145 427835 8722 79307686
Ataxia 64.06 10.99 27 427953 25012 79291396
Dementia 64.05 10.99 26 427954 24633 79291775
Dialysis 63.91 10.99 11 427969 18451 79297957
Blood sodium decreased 63.61 10.99 51 427929 33204 79283204
Hepatic encephalopathy 63.55 10.99 25 427955 24141 79292267
Retinitis 63.47 10.99 111 427869 5532 79310876
Exostosis 63.33 10.99 217 427763 16641 79299767
Pemphigoid 63.20 10.99 5 427975 15310 79301098
Malnutrition 63.04 10.99 21 427959 22481 79293927
Facet joint syndrome 62.80 10.99 167 427813 11135 79305273
Erectile dysfunction 62.79 10.99 4 427976 14660 79301748
Deafness transitory 62.75 10.99 48 427932 947 79315461
Bladder cancer 62.62 10.99 14 427966 19512 79296896
Accidental exposure to product 62.51 10.99 46 427934 31276 79285132
Viral upper respiratory tract infection 62.43 10.99 145 427835 8881 79307527
Coagulopathy 61.92 10.99 61 427919 35945 79280463
Bone swelling 61.72 10.99 60 427920 1654 79314754
White blood cell count increased 61.69 10.99 200 427780 74433 79241975
Hepatocellular injury 61.68 10.99 100 427880 47493 79268915
Aspiration 61.62 10.99 16 427964 20142 79296266
Labelled drug-drug interaction medication error 61.42 10.99 36 427944 27614 79288794
Hypoalbuminaemia 61.22 10.99 19 427961 21278 79295130
Prostate cancer 61.19 10.99 53 427927 33215 79283193
Second primary malignancy 61.19 10.99 4 427976 14346 79302062
Femur fracture 61.18 10.99 386 427594 38266 79278142
Pulmonary toxicity 61.11 10.99 180 427800 12734 79303674
Cellulitis 60.70 10.99 340 427640 108720 79207688
Muscle rigidity 60.36 10.99 16 427964 19866 79296542
Bone density abnormal 59.96 10.99 78 427902 2982 79313426
Ventricular fibrillation 59.78 10.99 50 427930 31876 79284532
Limb discomfort 59.63 10.99 340 427640 32510 79283898
Premature delivery 59.59 10.99 267 427713 23200 79293208
Glycosylated haemoglobin increased 59.42 10.99 15 427965 19245 79297163
Neck mass 59.41 10.99 94 427886 4310 79312098
Pulmonary congestion 59.19 10.99 36 427944 27064 79289344
Live birth 59.17 10.99 228 427752 18516 79297892
Aplastic anaemia 59.14 10.99 12 427968 17893 79298515
Agranulocytosis 58.93 10.99 94 427886 44936 79271472
Anticipatory anxiety 58.77 10.99 50 427930 1154 79315254
Blood pressure diastolic abnormal 58.53 10.99 231 427749 18971 79297437
Haemodialysis 58.32 10.99 13 427967 18155 79298253
Blood triglycerides increased 58.31 10.99 20 427960 21020 79295388
Dystonia 58.18 10.99 21 427959 21378 79295030
Troponin increased 57.50 10.99 16 427964 19239 79297169
Shock haemorrhagic 57.47 10.99 18 427962 20042 79296366
Drug tolerance 57.43 10.99 137 427843 8538 79307870
Presbyacusis 57.17 10.99 71 427909 2589 79313819
Product quality issue 56.66 10.99 59 427921 33881 79282527
Thyroid neoplasm 56.39 10.99 77 427903 3087 79313321
Tenderness 56.33 10.99 264 427716 23378 79293030
Neck pain 56.24 10.99 636 427344 74781 79241627
Bacteraemia 56.00 10.99 56 427924 32768 79283640
Hemiparesis 55.91 10.99 59 427921 33674 79282734
Head injury 55.85 10.99 71 427909 37298 79279110
Glomerular filtration rate decreased 55.69 10.99 26 427954 22676 79293732
Leukocytosis 55.67 10.99 92 427888 43363 79273045
Anger 55.66 10.99 12 427968 17150 79299258
Ovarian neoplasm 55.40 10.99 37 427943 584 79315824
Acute coronary syndrome 55.35 10.99 22 427958 21111 79295297
Shock 55.04 10.99 93 427887 43455 79272953
Mental disorder 55.03 10.99 52 427928 31250 79285158
Parkinsonism 55.01 10.99 11 427969 16573 79299835
Depression 54.99 10.99 825 427155 215965 79100443
Lip dry 54.92 10.99 195 427785 15223 79301185
Adjustment disorder with depressed mood 54.33 10.99 138 427842 8948 79307460
Graft versus host disease 54.16 10.99 8 427972 15018 79301390
Tuberculosis 53.95 10.99 192 427788 15006 79301402
Deep vein thrombosis postoperative 53.91 10.99 153 427827 10599 79305809
Fear of injection 53.83 10.99 122 427858 7352 79309056
Speech disorder 53.76 10.99 134 427846 54311 79262097
Pericardial effusion 53.73 10.99 104 427876 46133 79270275
Subacute cutaneous lupus erythematosus 53.66 10.99 80 427900 3481 79312927
Wound infection 53.62 10.99 263 427717 23728 79292680
Abdominal pain lower 53.34 10.99 55 427925 31727 79284681
Transfusion 52.99 10.99 24 427956 21306 79295102
Mouth ulceration 52.67 10.99 370 427610 38024 79278384
Obesity 52.66 10.99 346 427634 34779 79281629
Delusion 52.29 10.99 22 427958 20401 79296007
Mydriasis 52.06 10.99 15 427965 17628 79298780
Urine output decreased 51.94 10.99 16 427964 18006 79298402
Polyuria 51.86 10.99 9 427971 15005 79301403
Nightmare 51.58 10.99 38 427942 25823 79290585
Acquired pigmented retinopathy 51.56 10.99 13 427967 4 79316404
Neutrophil count increased 51.48 10.99 49 427931 29347 79287061
Thrombotic microangiopathy 51.20 10.99 22 427958 20147 79296261
International normalised ratio fluctuation 51.19 10.99 77 427903 3377 79313031
Osteoporotic fracture 51.10 10.99 86 427894 4154 79312254
Cataract 50.99 10.99 534 427446 61586 79254822
Metastases to lung 50.80 10.99 17 427963 18146 79298262
Brain oedema 50.54 10.99 37 427943 25226 79291182
Infusion site reaction 50.54 10.99 77 427903 3416 79312992
Faeces discoloured 50.49 10.99 49 427931 29078 79287330
Ejection fraction decreased 50.33 10.99 67 427913 34510 79281898
Salivary hypersecretion 50.30 10.99 8 427972 14216 79302192
Bronchospasm 50.27 10.99 36 427944 24823 79291585
Hypothyroidism 50.15 10.99 131 427849 52261 79264147
Feeling hot 50.12 10.99 159 427821 59575 79256833
Lyme disease 50.10 10.99 75 427905 3275 79313133
Device issue 50.09 10.99 43 427937 27065 79289343
Metastases to central nervous system 50.05 10.99 13 427967 16362 79300046
Haematotoxicity 50.03 10.99 11 427969 15508 79300900
Bloody discharge 50.01 10.99 57 427923 1896 79314512
Hypersomnia 49.96 10.99 31 427949 23055 79293353
Pollakiuria 49.69 10.99 77 427903 37240 79279168
Skin exfoliation 49.58 10.99 142 427838 54958 79261450
Neck deformity 49.40 10.99 55 427925 1782 79314626
Product use in unapproved indication 49.29 10.99 1723 426257 248636 79067772
Mesenteritis 49.23 10.99 28 427952 326 79316082
Lower gastrointestinal haemorrhage 48.90 10.99 13 427967 16112 79300296
Hypovolaemia 48.71 10.99 17 427963 17674 79298734
Feeling abnormal 48.66 10.99 583 427397 158616 79157792
Acute hepatic failure 48.43 10.99 54 427926 30059 79286349
Myelodysplastic syndrome 48.01 10.99 55 427925 30246 79286162
Blood glucose decreased 48.00 10.99 42 427938 26192 79290216
Asphyxia 47.88 10.99 4 427976 11716 79304692
Mania 47.84 10.99 19 427961 18241 79298167
Aspartate aminotransferase increased 47.80 10.99 494 427486 138147 79178261
Spinal column injury 47.77 10.99 59 427921 2139 79314269
Tender joint count 47.60 10.99 23 427957 186 79316222
Hyperammonaemia 47.58 10.99 3 427977 11090 79305318
Arteriosclerosis coronary artery 47.56 10.99 18 427962 17798 79298610
Swelling face 47.08 10.99 209 427771 71003 79245405
Pleural fibrosis 46.91 10.99 82 427898 4085 79312323
Autoimmune disorder 46.78 10.99 195 427785 16417 79299991
Lipase increased 46.78 10.99 15 427965 16451 79299957
Maternal exposure timing unspecified 46.77 10.99 99 427881 5693 79310715
Weight decreased 46.23 10.99 1503 426477 353695 78962713
Clostridium difficile infection 46.21 10.99 100 427880 42585 79273823
Complication associated with device 46.17 10.99 18 427962 17478 79298930
Lupus vasculitis 45.98 10.99 32 427948 542 79315866
Muscle spasticity 45.58 10.99 232 427748 21243 79295165
Sinus bradycardia 45.50 10.99 41 427939 25206 79291202
Injection site reaction 45.47 10.99 472 427508 54313 79262095
Pleural thickening 44.94 10.99 67 427913 2915 79313493
Hypertensive crisis 44.80 10.99 28 427952 20742 79295666
Joint dislocation 44.73 10.99 195 427785 16744 79299664
Stevens-Johnson syndrome 44.73 10.99 89 427891 39077 79277331
Hallucination, auditory 44.49 10.99 28 427952 20665 79295743
Brain injury 44.24 10.99 5 427975 11512 79304896
Metastases to lymph nodes 44.03 10.99 3 427977 10394 79306014
Drug specific antibody 43.91 10.99 62 427918 2566 79313842
Incontinence 43.76 10.99 11 427969 14153 79302255
Infective pulmonary exacerbation of cystic fibrosis 43.74 10.99 8 427972 12843 79303565
C-reactive protein 43.61 10.99 88 427892 4891 79311517
Feeling cold 43.54 10.99 54 427926 28675 79287733
Mental impairment 43.41 10.99 24 427956 19012 79297396
Peritonitis 43.23 10.99 52 427928 27984 79288424
Pulmonary hypertension 43.19 10.99 124 427856 47956 79268452
Drug level decreased 42.95 10.99 12 427968 14390 79302018
Drug level increased 42.84 10.99 93 427887 39558 79276850
Juvenile idiopathic arthritis 42.70 10.99 85 427895 4678 79311730
Antibody test positive 42.46 10.99 63 427917 2729 79313679
Renal tubular necrosis 42.39 10.99 43 427937 24996 79291412
Joint lock 42.36 10.99 68 427912 3157 79313251
Oesophageal carcinoma 42.11 10.99 5 427975 11079 79305329
Faecaloma 42.05 10.99 6 427974 11558 79304850
Sinus tachycardia 42.04 10.99 84 427896 36824 79279584
Prothrombin time prolonged 42.00 10.99 19 427961 16880 79299528
Haemorrhagic stroke 41.92 10.99 5 427975 11041 79305367
Diabetes mellitus inadequate control 41.85 10.99 41 427939 24223 79292185
Skin reaction 41.69 10.99 184 427796 15884 79300524
Bone disorder 41.63 10.99 208 427772 18905 79297503
Drug resistance 41.60 10.99 104 427876 42109 79274299
Toxic epidermal necrolysis 41.51 10.99 113 427867 44468 79271940
Face oedema 41.49 10.99 54 427926 28082 79288326
Toxic encephalopathy 41.45 10.99 6 427974 11434 79304974
Polyneuropathy 41.43 10.99 41 427939 24110 79292298
Therapy interrupted 41.42 10.99 65 427915 31276 79285132
Depressed mood 41.41 10.99 128 427852 48352 79268056
Petechiae 41.30 10.99 30 427950 20535 79295873
Cholangitis 41.30 10.99 9 427971 12767 79303641
Anal incontinence 41.29 10.99 23 427957 18145 79298263
Hepatic cytolysis 41.19 10.99 51 427929 27100 79289308
Peripheral venous disease 41.14 10.99 182 427798 15727 79300681
Blood phosphorus increased 41.01 10.99 4 427976 10343 79306065
Lip swelling 40.93 10.99 100 427880 40811 79275597
Butterfly rash 40.91 10.99 48 427932 1648 79314760
Hyperuricaemia 40.91 10.99 7 427973 11792 79304616
Appendicitis 40.90 10.99 31 427949 20763 79295645
Limb deformity 40.87 10.99 71 427909 3519 79312889
Pathogen resistance 40.86 10.99 13 427967 14329 79302079
Oesophagitis 40.80 10.99 42 427938 24247 79292161
Foot operation 40.64 10.99 93 427887 5640 79310768
Pneumonitis 40.60 10.99 178 427802 60682 79255726
Blood magnesium decreased 40.37 10.99 19 427961 16493 79299915
Acute pulmonary oedema 40.36 10.99 13 427967 14217 79302191
Activated partial thromboplastin time prolonged 40.35 10.99 13 427967 14215 79302193
Psychomotor hyperactivity 40.26 10.99 20 427960 16829 79299579
Mycotic allergy 40.03 10.99 45 427935 1474 79314934
Diplopia 40.01 10.99 74 427906 33392 79283016
Sleep apnoea syndrome 39.87 10.99 85 427895 36393 79280015
Anhedonia 39.86 10.99 15 427965 14883 79301525
Therapy cessation 39.84 10.99 89 427891 37473 79278935
Nail disorder 39.76 10.99 147 427833 11705 79304703
Hair follicle tumour benign 39.53 10.99 27 427953 443 79315965
Oliguria 39.51 10.99 19 427961 16290 79300118
Transplant rejection 39.50 10.99 28 427952 19409 79296999
Acidosis 39.46 10.99 29 427951 19733 79296675
Respiratory disorder 39.40 10.99 391 427589 44465 79271943
Frequent bowel movements 39.28 10.99 61 427919 29478 79286930
Pancreatic carcinoma 39.23 10.99 12 427968 13565 79302843
Failure to thrive 38.99 10.99 8 427972 11836 79304572
Cholecystitis 38.93 10.99 37 427943 22175 79294233
Thirst 38.93 10.99 26 427954 18593 79297815
Sudden death 38.87 10.99 38 427942 22473 79293935
Diffuse alopecia 38.73 10.99 36 427944 937 79315471
Arteriosclerosis 38.72 10.99 25 427955 18202 79298206
Prostatic specific antigen increased 38.69 10.99 5 427975 10381 79306027
Prescribed overdose 38.68 10.99 341 427639 37542 79278866
Peripheral sensory neuropathy 38.60 10.99 11 427969 13022 79303386
Mood altered 38.57 10.99 24 427956 17823 79298585
Device difficult to use 38.37 10.99 12 427968 13373 79303035
Delirium 38.30 10.99 281 427699 84346 79232062
Enterocolitis 38.18 10.99 15 427965 14497 79301911
Hyperthermia 37.96 10.99 25 427955 18012 79298396
Anuria 37.83 10.99 34 427946 20929 79295479
Nausea 37.82 10.99 4530 423450 952666 78363742
Diarrhoea haemorrhagic 37.69 10.99 12 427968 13222 79303186
Renal injury 37.65 10.99 22 427958 16905 79299503
Inappropriate schedule of product administration 37.60 10.99 498 427482 133130 79183278
Coeliac disease 37.42 10.99 140 427840 11211 79305197
Gastric haemorrhage 37.28 10.99 17 427963 15033 79301375
Device malfunction 37.27 10.99 36 427944 21412 79294996
Vascular access complication 37.23 10.99 52 427928 2130 79314278
Post transplant lymphoproliferative disorder 37.21 10.99 8 427972 11456 79304952
Granulocytopenia 37.06 10.99 8 427972 11423 79304985
Needle issue 36.95 10.99 12 427968 13056 79303352
Extremity contracture 36.86 10.99 46 427934 1686 79314722
Injection site pain 36.85 10.99 483 427497 129355 79187053
Duodenal ulcer 36.80 10.99 21 427959 16348 79300060
Cushingoid 36.80 10.99 124 427856 9428 79306980
End stage renal disease 36.78 10.99 10 427970 12210 79304198
Pulseless electrical activity 36.66 10.99 15 427965 14145 79302263
Device leakage 36.43 10.99 7 427973 10849 79305559
Eye pruritus 36.36 10.99 34 427946 20536 79295872
Pustular psoriasis 36.35 10.99 80 427900 4726 79311682
Wrist surgery 35.99 10.99 32 427948 785 79315623
Heart rate irregular 35.84 10.99 76 427904 32603 79283805
Hypocalcaemia 35.80 10.99 142 427838 49782 79266626
Mass excision 35.61 10.99 23 427957 342 79316066
Colitis ischaemic 35.55 10.99 19 427961 15340 79301068
Antinuclear antibody positive 35.47 10.99 108 427872 7782 79308626
Red cell distribution width decreased 35.42 10.99 49 427931 1989 79314419
Gastric cancer 35.38 10.99 6 427974 10173 79306235
Haemodynamic instability 35.37 10.99 25 427955 17357 79299051
Suspected suicide 35.11 10.99 7 427973 10569 79305839
Laryngeal disorder 35.10 10.99 36 427944 1060 79315348
Metabolic encephalopathy 35.06 10.99 4 427976 9143 79307265
Dry eye 34.94 10.99 327 427653 36604 79279804
Multiple sclerosis 34.70 10.99 41 427939 22241 79294167
Pneumocystis jirovecii pneumonia 34.50 10.99 77 427903 32431 79283977
Immune thrombocytopenia 34.44 10.99 27 427953 17778 79298630
Body tinea 34.38 10.99 46 427934 1808 79314600
Product prescribing error 34.38 10.99 124 427856 44689 79271719
Pulmonary thrombosis 34.37 10.99 143 427837 12028 79304380
Nervous system disorder 34.26 10.99 57 427923 26799 79289609
Cytology abnormal 34.24 10.99 22 427958 324 79316084
Anovulatory cycle 34.13 10.99 16 427964 120 79316288
Synovial fluid analysis 34.13 10.99 52 427928 2307 79314101
Asthma 33.93 10.99 515 427465 134580 79181828
Hospice care 33.93 10.99 7 427973 10317 79306091
Tenosynovitis stenosans 33.91 10.99 60 427920 3018 79313390
Cardiac failure acute 33.80 10.99 31 427949 18898 79297510
Overlap syndrome 33.46 10.99 34 427946 990 79315418
Ankle operation 33.44 10.99 35 427945 1056 79315352
Post procedural haemorrhage 33.31 10.99 16 427964 13728 79302680
Supraventricular tachycardia 33.28 10.99 39 427941 21231 79295177
Infiltration anaesthesia 33.26 10.99 17 427963 157 79316251
Ankle arthroplasty 33.25 10.99 41 427939 1484 79314924
Blood uric acid increased 33.24 10.99 15 427965 13345 79303063
Personality change 33.21 10.99 7 427973 10163 79306245
Panic attack 33.18 10.99 49 427931 24167 79292241
Retching 33.14 10.99 27 427953 17440 79298968
Gout 33.02 10.99 51 427929 24698 79291710
Cold sweat 32.95 10.99 31 427949 18668 79297740
Lupus myocarditis 32.89 10.99 14 427966 81 79316327
Joint ankylosis 32.88 10.99 49 427931 2131 79314277
Hepatic cancer 32.87 10.99 8 427972 10521 79305887
Gastrointestinal pain 32.86 10.99 122 427858 9733 79306675
Myocarditis 32.78 10.99 41 427939 21692 79294716
Latent tuberculosis 32.69 10.99 62 427918 3291 79313117
Coronary artery stenosis 32.69 10.99 13 427967 12471 79303937
Transaminases abnormal 32.60 10.99 31 427949 831 79315577
Walking aid user 32.49 10.99 124 427856 10024 79306384
Proctalgia 32.42 10.99 7 427973 9994 79306414
Hemiplegia 32.41 10.99 20 427960 14919 79301489
Alanine aminotransferase increased 32.40 10.99 646 427334 161924 79154484
Pneumonia fungal 32.22 10.99 10 427970 11200 79305208
Respiratory acidosis 32.18 10.99 10 427970 11190 79305218
Ear infection 32.14 10.99 304 427676 34128 79282280
Eye swelling 32.11 10.99 58 427922 26410 79289998
Large intestine polyp 32.04 10.99 14 427966 12694 79303714
Partial seizures 31.86 10.99 5 427975 8973 79307435
Victim of child abuse 31.79 10.99 32 427948 921 79315487
Heart rate increased 31.78 10.99 456 427524 120268 79196140
Eosinophil count increased 31.76 10.99 27 427953 17078 79299330
Right ventricular failure 31.75 10.99 48 427932 23449 79292959
Device occlusion 31.66 10.99 12 427968 11854 79304554
Leukoencephalopathy 31.60 10.99 3 427977 7926 79308482
Kidney transplant rejection 31.57 10.99 8 427972 10238 79306170
Mean platelet volume decreased 31.53 10.99 55 427925 2735 79313673
Paraesthesia oral 31.53 10.99 38 427942 20433 79295975
Blood pressure systolic increased 31.47 10.99 520 427460 66466 79249942
Visual acuity reduced 31.11 10.99 70 427910 29399 79287009
Aplasia 31.06 10.99 3 427977 7817 79308591
Therapeutic product ineffective for unapproved indication 30.96 10.99 17 427963 184 79316224
Lung infiltration 30.77 10.99 47 427933 22865 79293543
Cholecystitis acute 30.61 10.99 17 427963 13434 79302974
Gastritis erosive 30.60 10.99 10 427970 10837 79305571
Exposure to toxic agent 30.53 10.99 6 427974 9152 79307256
Amylase increased 30.47 10.99 11 427969 11198 79305210
Peritonitis bacterial 30.40 10.99 7 427973 9560 79306848
Cartilage atrophy 30.39 10.99 16 427964 158 79316250
Restrictive cardiomyopathy 30.29 10.99 32 427948 976 79315432
Histoplasmosis disseminated 30.07 10.99 49 427931 2304 79314104
Gastric ulcer 30.05 10.99 88 427892 33817 79282591
Optical coherence tomography abnormal 29.73 10.99 9 427971 14 79316394
Toxic skin eruption 29.68 10.99 46 427934 22247 79294161
Systemic infection 29.31 10.99 8 427972 9744 79306664
Sickle cell anaemia with crisis 29.06 10.99 4 427976 7918 79308490
Hypercalcaemia 29.06 10.99 325 427655 38105 79278303
BK virus infection 28.87 10.99 6 427974 8798 79307610
Ageusia 28.80 10.99 28 427952 16604 79299804
Eyelid oedema 28.77 10.99 19 427961 13668 79302740
Ketoacidosis 28.73 10.99 4 427976 7850 79308558
Ileus paralytic 28.72 10.99 8 427972 9612 79306796
Cutaneous lupus erythematosus 28.63 10.99 55 427925 2948 79313460
Staphylococcal infection 28.62 10.99 189 427791 58106 79258302
Angina unstable 28.42 10.99 28 427952 16499 79299909
Hydronephrosis 28.40 10.99 31 427949 17423 79298985
Blood magnesium increased 28.40 10.99 60 427920 3446 79312962
Enteritis 28.35 10.99 22 427958 14561 79301847
Cutaneous coccidioidomycosis 28.31 10.99 9 427971 18 79316390
Coma scale abnormal 28.28 10.99 6 427974 8672 79307736
Chromaturia 28.13 10.99 60 427920 25686 79290722
Blood loss anaemia 28.13 10.99 25 427955 15473 79300935
Eyelid ptosis 28.11 10.99 12 427968 11032 79305376
Myopathy toxic 28.04 10.99 32 427948 1066 79315342
Nervousness 27.99 10.99 89 427891 33326 79283082
Incoherent 27.95 10.99 4 427976 7688 79308720
Pneumonia viral 27.77 10.99 110 427870 9048 79307360
Bronchitis chronic 27.77 10.99 69 427911 4413 79311995
Klebsiella infection 27.77 10.99 26 427954 15694 79300714
Chorioretinitis 27.73 10.99 31 427949 1009 79315399
Anal abscess 27.52 10.99 8 427972 9347 79307061
Hypofibrinogenaemia 27.38 10.99 43 427937 1959 79314449
Anaphylactic shock 27.35 10.99 100 427880 35896 79280512
Fistula 27.15 10.99 18 427962 12922 79303486
Intestinal polyp 27.14 10.99 44 427936 2060 79314348
Intestinal ischaemia 27.12 10.99 19 427961 13251 79303157
Pulmonary arterial hypertension 27.09 10.99 71 427909 28295 79288113
Fracture delayed union 27.04 10.99 44 427936 2066 79314342
Deafness neurosensory 26.97 10.99 90 427890 6808 79309600
Scleritis 26.92 10.99 67 427913 4289 79312119
Fear 26.83 10.99 48 427932 21938 79294470
Femoral neck fracture 26.80 10.99 10 427970 9974 79306434
Hepatic lesion 26.79 10.99 3 427977 6956 79309452
Atrioventricular block first degree 26.72 10.99 17 427963 12474 79303934
Catatonia 26.67 10.99 7 427973 8749 79307659
Blood potassium increased 26.66 10.99 75 427905 29200 79287208
Abnormal dreams 26.59 10.99 14 427966 11398 79305010
Drug level above therapeutic 26.52 10.99 7 427973 8716 79307692
Respiratory depression 26.51 10.99 69 427911 27561 79288847
Drug reaction with eosinophilia and systemic symptoms 26.41 10.99 219 427761 64025 79252383
Metastasis 26.40 10.99 3 427977 6877 79309531
Osteopenia 26.38 10.99 179 427801 18185 79298223
Hypoxic-ischaemic encephalopathy 26.33 10.99 5 427975 7815 79308593
Haemorrhoids 26.25 10.99 75 427905 29053 79287355
Hyperbilirubinaemia 26.08 10.99 58 427922 24460 79291948
Double stranded DNA antibody positive 25.99 10.99 21 427959 450 79315958
Micturition urgency 25.96 10.99 18 427962 12623 79303785
Chronic graft versus host disease 25.91 10.99 3 427977 6778 79309630
Phospholipidosis 25.85 10.99 16 427964 220 79316188
Product substitution issue 25.83 10.99 43 427937 20213 79296195
Amenorrhoea 25.73 10.99 5 427975 7687 79308721
Cerebral ischaemia 25.69 10.99 14 427966 11181 79305227
Cerebral atrophy 25.48 10.99 6 427974 8069 79308339
Hypoacusis 25.47 10.99 80 427900 30070 79286338
Eosinophilia 25.42 10.99 141 427839 45204 79271204
Hypernatraemia 25.41 10.99 24 427956 14427 79301981
Rotator cuff repair 25.35 10.99 40 427940 1830 79314578
Cytopenia 25.33 10.99 44 427936 20339 79296069
Adenovirus infection 25.26 10.99 7 427973 8440 79307968
Urticaria 25.26 10.99 1226 426754 183975 79132433
Pulmonary haemorrhage 25.23 10.99 25 427955 14692 79301716
Stress at work 25.18 10.99 31 427949 1120 79315288
Device use error 25.10 10.99 4 427976 7097 79309311
Polydipsia 25.04 10.99 3 427977 6602 79309806
Electrocardiogram ST segment elevation 25.03 10.99 7 427973 8390 79308018
Wheezing 24.95 10.99 458 427522 116206 79200202
Tongue disorder 24.94 10.99 144 427836 13831 79302577
Cutaneous vasculitis 24.93 10.99 99 427881 8153 79308255
Rash papular 24.85 10.99 50 427930 21866 79294542
Left ventricular dysfunction 24.79 10.99 41 427939 19320 79297088
Large intestine perforation 24.68 10.99 25 427955 14542 79301866
Hyperventilation 24.66 10.99 6 427974 7893 79308515
Hepatic necrosis 24.62 10.99 9 427971 9091 79307317
Infection reactivation 24.52 10.99 48 427932 2609 79313799
Hepatitis C 24.47 10.99 17 427963 11908 79304500
Erythema 24.43 10.99 965 427015 222325 79094083
Retinal degeneration 24.38 10.99 32 427948 1234 79315174
Multiple allergies 24.33 10.99 116 427864 10344 79306064
Hypotonia 24.29 10.99 20 427960 12850 79303558
Drug level below therapeutic 24.26 10.99 11 427969 9759 79306649
Procedural pain 24.23 10.99 55 427925 23029 79293379
Refusal of treatment by patient 24.14 10.99 9 427971 8982 79307426
Staphylococcal sepsis 24.13 10.99 26 427954 14700 79301708
Cytomegalovirus viraemia 24.10 10.99 20 427960 12801 79303607
Influenza like illness 24.10 10.99 257 427723 71450 79244958
Tricuspid valve incompetence 24.09 10.99 43 427937 19669 79296739
Mycobacterium tuberculosis complex test positive 24.04 10.99 49 427931 2743 79313665
Urosepsis 24.04 10.99 68 427912 26427 79289981
Cardiac failure chronic 24.03 10.99 15 427965 11120 79305288
Knee deformity 24.01 10.99 32 427948 1253 79315155
Soft tissue disorder 23.80 10.99 56 427924 3459 79312949
Product monitoring error 23.77 10.99 9 427971 8897 79307511
Blood albumin decreased 23.67 10.99 60 427920 24183 79292225
Cardiomegaly 23.64 10.99 68 427912 26284 79290124
Apnoea 23.60 10.99 17 427963 11687 79304721
Disease susceptibility 23.55 10.99 17 427963 306 79316102
Hypoventilation 23.53 10.99 5 427975 7219 79309189
Fluid intake reduced 23.49 10.99 3 427977 6285 79310123
Vasculitic rash 23.33 10.99 42 427938 2142 79314266
Dyslipidaemia 23.32 10.99 17 427963 11616 79304792
Cholecystitis chronic 23.31 10.99 12 427968 9894 79306514
Metabolic disorder 23.28 10.99 10 427970 9160 79307248
Carpal tunnel syndrome 23.26 10.99 182 427798 19346 79297062
Rheumatic disorder 23.25 10.99 52 427928 3106 79313302
Decubitus ulcer 23.24 10.99 30 427950 15657 79300751
Rhinitis allergic 23.23 10.99 19 427961 12250 79304158
Palindromic rheumatism 23.13 10.99 19 427961 417 79315991
Ocular toxicity 23.05 10.99 26 427954 855 79315553
Hypomania 23.03 10.99 6 427974 7538 79308870
Loss of employment 22.99 10.99 46 427934 2541 79313867
Faeces soft 22.91 10.99 8 427972 8315 79308093
Generalised oedema 22.90 10.99 59 427921 23650 79292758
Erysipelas 22.89 10.99 15 427965 10835 79305573
Laryngitis 22.84 10.99 156 427824 15883 79300525
Stress cardiomyopathy 22.80 10.99 16 427964 11150 79305258
Personality disorder 22.79 10.99 3 427977 6143 79310265
Atrioventricular block 22.78 10.99 25 427955 14016 79302392
Gastric ulcer haemorrhage 22.67 10.99 10 427970 9017 79307391
Systemic inflammatory response syndrome 22.67 10.99 17 427963 11448 79304960
Nodular regenerative hyperplasia 22.58 10.99 32 427948 1329 79315079
Renal disorder 22.48 10.99 133 427847 41972 79274436
Cachexia 22.47 10.99 16 427964 11067 79305341
COVID-19 22.47 10.99 659 427321 157015 79159393
Smear cervix abnormal 22.42 10.99 45 427935 2491 79313917
Drug screen positive 22.39 10.99 3 427977 6060 79310348
Hiccups 22.37 10.99 13 427967 10018 79306390
Heart rate abnormal 22.36 10.99 3 427977 6054 79310354
Antiphospholipid syndrome 22.32 10.99 38 427942 1853 79314555
Renal tubular disorder 22.16 10.99 4 427976 6482 79309926
Urticarial vasculitis 22.08 10.99 21 427959 563 79315845
Hypovolaemic shock 22.04 10.99 20 427960 12256 79304152
Photosensitivity reaction 22.00 10.99 191 427789 20936 79295472
Proctitis 21.90 10.99 4 427976 6428 79309980
Depressive symptom 21.86 10.99 4 427976 6419 79309989
Liver disorder 21.85 10.99 526 427454 71891 79244517
No adverse event 21.85 10.99 300 427680 36892 79279516
Thinking abnormal 21.83 10.99 23 427957 13138 79303270
Colitis ulcerative 21.75 10.99 104 427876 34638 79281770
Hepatitis fulminant 21.75 10.99 6 427974 7256 79309152
Taste disorder 21.69 10.99 32 427948 15791 79300617
Lacrimation increased 21.66 10.99 56 427924 22421 79293987
Hyperphosphataemia 21.63 10.99 4 427976 6372 79310036
Muscular weakness 21.62 10.99 677 427303 160052 79156356
Prescribed underdose 21.59 10.99 248 427732 29266 79287142
Allergy to vaccine 21.57 10.99 14 427966 210 79316198
Mean cell volume decreased 21.57 10.99 67 427913 4880 79311528
PaO2/FiO2 ratio decreased 21.56 10.99 8 427972 30 79316378
Autoimmune haemolytic anaemia 21.50 10.99 9 427971 8371 79308037
Medication error 21.49 10.99 250 427730 68392 79248016
Duodenitis 21.35 10.99 8 427972 7959 79308449
Skin toxicity 21.21 10.99 9 427971 8305 79308103
Incorrect product administration duration 21.10 10.99 20 427960 12002 79304406
Rash erythematous 21.08 10.99 203 427777 57566 79258842
Wrong product administered 21.08 10.99 11 427969 9001 79307407
Pleuritic pain 21.07 10.99 109 427871 10043 79306365
Drug specific antibody present 21.07 10.99 81 427899 6571 79309837
Shoulder operation 21.03 10.99 46 427934 2706 79313702
Coronary artery occlusion 20.97 10.99 31 427949 15284 79301124
Carcinoid tumour pulmonary 20.93 10.99 17 427963 367 79316041
Trigger finger 20.89 10.99 60 427920 4185 79312223
Breast cancer metastatic 20.87 10.99 10 427970 8592 79307816
C-reactive protein decreased 20.85 10.99 45 427935 2623 79313785
Middle lobe syndrome 20.78 10.99 8 427972 34 79316374
Central nervous system lupus 20.78 10.99 19 427961 484 79315924
Hypercapnia 20.76 10.99 11 427969 8924 79307484
Benign prostatic hyperplasia 20.75 10.99 19 427961 11593 79304815
Bradyphrenia 20.75 10.99 16 427964 10624 79305784
Pregnancy 20.72 10.99 228 427752 26623 79289785
Bacterial sepsis 20.72 10.99 9 427971 8189 79308219
Aortic arteriosclerosis 20.69 10.99 11 427969 8907 79307501
Neuropsychiatric lupus 20.68 10.99 13 427967 184 79316224
Vascular device infection 20.62 10.99 15 427965 10261 79306147
Brain natriuretic peptide increased 20.62 10.99 11 427969 8889 79307519
Respiration abnormal 20.57 10.99 8 427972 7780 79308628
Gastrointestinal perforation 20.50 10.99 4 427976 6133 79310275
Nystagmus 20.48 10.99 14 427966 9890 79306518
Escherichia sepsis 20.48 10.99 10 427970 8498 79307910
Limb operation 20.45 10.99 52 427928 3374 79313034
Colon cancer 20.27 10.99 29 427951 14494 79301914
Eczema 20.21 10.99 132 427848 40686 79275722
Body temperature increased 20.19 10.99 343 427637 44077 79272331
Sensory disturbance 20.18 10.99 31 427949 15046 79301362
Diabetic eye disease 20.16 10.99 12 427968 153 79316255
Transaminases increased 20.10 10.99 179 427801 51564 79264844
Tendonitis 20.10 10.99 206 427774 23624 79292784
Peripheral ischaemia 20.05 10.99 13 427967 9444 79306964
Occult blood positive 20.04 10.99 6 427974 6877 79309531
Androgenetic alopecia 19.96 10.99 12 427968 156 79316252
Pulse absent 19.95 10.99 15 427965 10088 79306320
Rash pruritic 19.75 10.99 514 427466 71115 79245293
Placenta accreta 19.75 10.99 13 427967 200 79316208
Device breakage 19.64 10.99 17 427963 10658 79305750
Paradoxical drug reaction 19.62 10.99 7 427973 7178 79309230
Fibrin D dimer increased 19.60 10.99 11 427969 8643 79307765
Gingival pain 19.59 10.99 12 427968 8986 79307422
Nephropathy toxic 19.58 10.99 51 427929 20368 79296040
Secretion discharge 19.58 10.99 143 427837 14879 79301529
Cerebellar syndrome 19.56 10.99 3 427977 5477 79310931
Staphylococcal bacteraemia 19.55 10.99 22 427958 12196 79304212
Macular oedema 19.53 10.99 3 427977 5471 79310937
Dermatitis acneiform 19.52 10.99 15 427965 9978 79306430
Obsessive-compulsive disorder 19.52 10.99 4 427976 5923 79310485
Azotaemia 19.51 10.99 10 427970 8266 79308142
Precancerous cells present 19.47 10.99 28 427952 1179 79315229
Thrombosis in device 19.38 10.99 3 427977 5439 79310969
Back pain 19.37 10.99 1388 426592 302792 79013616
Dizziness postural 19.36 10.99 20 427960 11529 79304879
Natural killer-cell leukaemia 19.33 10.99 10 427970 95 79316313
Posterior reversible encephalopathy syndrome 19.32 10.99 74 427906 26207 79290201
Intermenstrual bleeding 19.32 10.99 4 427976 5880 79310528
Oral lichen planus 19.30 10.99 23 427957 803 79315605
Retinal haemorrhage 19.26 10.99 10 427970 8207 79308201
Spinal meningioma benign 19.24 10.99 10 427970 96 79316312
Kidney duplex 19.21 10.99 6 427974 11 79316397
Tinnitus 19.20 10.99 149 427831 44184 79272224
Facial paralysis 19.18 10.99 54 427926 21018 79295390
Underdose 19.18 10.99 102 427878 33049 79283359
Vaginal discharge 19.17 10.99 8 427972 7455 79308953
Lupus vulgaris 19.16 10.99 50 427930 3296 79313112
Gait disturbance 19.12 10.99 1326 426654 206180 79110228
Epidural lipomatosis 19.10 10.99 28 427952 1200 79315208
Congestive cardiomyopathy 19.08 10.99 21 427959 11759 79304649
Device failure 19.08 10.99 5 427975 6256 79310152
Pruritus allergic 19.07 10.99 30 427950 1369 79315039
Humoral immune defect 19.05 10.99 17 427963 419 79315989
Human herpesvirus 6 infection 19.03 10.99 3 427977 5367 79311041
Intervertebral disc compression 19.02 10.99 29 427951 1287 79315121
Hepatitis cholestatic 19.00 10.99 28 427952 13824 79302584
Therapy change 18.89 10.99 8 427972 7391 79309017
Cardiovascular disorder 18.88 10.99 43 427937 17982 79298426
Hypopnoea 18.84 10.99 3 427977 5326 79311082
Hip fracture 18.73 10.99 93 427887 30668 79285740
Infection susceptibility increased 18.70 10.99 53 427927 3668 79312740
Blood calcium increased 18.61 10.99 17 427963 10383 79306025
Ventricular tachycardia 18.61 10.99 140 427840 41795 79274613
Blood pressure fluctuation 18.56 10.99 482 427498 66663 79249745
Lung disorder 18.56 10.99 565 427415 79992 79236416
Somnambulism 18.55 10.99 4 427976 5717 79310691
External auditory canal atresia 18.55 10.99 6 427974 13 79316395
Bradykinesia 18.54 10.99 10 427970 8033 79308375
Exercise tolerance decreased 18.52 10.99 13 427967 9058 79307350
Clostridial infection 18.52 10.99 4 427976 5710 79310698
Dermatitis atopic 18.52 10.99 16 427964 10040 79306368
Haemoglobin increased 18.49 10.99 5 427975 6127 79310281
Short stature 18.48 10.99 21 427959 696 79315712
Tendon disorder 18.42 10.99 82 427898 7104 79309304
Rash macular 18.39 10.99 86 427894 28813 79287595
Parainfluenzae virus infection 18.37 10.99 4 427976 5678 79310730
Central nervous system lesion 18.36 10.99 27 427953 13341 79303067
Brain death 18.35 10.99 4 427976 5673 79310735
Sudden cardiac death 18.34 10.99 3 427977 5222 79311186
Blindness 18.34 10.99 84 427896 28299 79288109
Gingivitis 18.32 10.99 13 427967 9008 79307400
Hepatocellular carcinoma 18.32 10.99 13 427967 9008 79307400
Product label confusion 18.31 10.99 32 427948 1594 79314814
Electrocardiogram abnormal 18.29 10.99 39 427941 16698 79299710
Retinal coloboma 18.25 10.99 6 427974 14 79316394
Iris coloboma 18.25 10.99 6 427974 14 79316394
Hiatus hernia 18.22 10.99 64 427916 23248 79293160
Hepatomegaly 18.21 10.99 47 427933 18827 79297581
Injection site mass 18.17 10.99 52 427928 20132 79296276
Sensory loss 18.08 10.99 26 427954 12965 79303443
Viral vasculitis 18.04 10.99 11 427969 147 79316261
Apathy 18.03 10.99 26 427954 12951 79303457
Blood chloride increased 18.01 10.99 3 427977 5153 79311255
Memory impairment 17.99 10.99 459 427521 111275 79205133
Pathological fracture 17.95 10.99 18 427962 10519 79305889
Infective tenosynovitis 17.91 10.99 16 427964 395 79316013
Swollen joint count 17.88 10.99 27 427953 1188 79315220
Interstitial lung disease 17.87 10.99 757 427223 111843 79204565
Atrial flutter 17.83 10.99 58 427922 21567 79294841
Snoring 17.83 10.99 4 427976 5562 79310846
Blood chloride decreased 17.67 10.99 11 427969 8166 79308242
Vaginal haemorrhage 17.66 10.99 59 427921 21758 79294650
Peripheral coldness 17.63 10.99 37 427943 15933 79300475
Dermatomyositis 17.62 10.99 51 427929 3572 79312836
Adenoiditis 17.61 10.99 7 427973 33 79316375
Bacterial test positive 17.56 10.99 9 427971 7440 79308968
Menopausal symptoms 17.56 10.99 35 427945 1928 79314480
Gastrointestinal toxicity 17.48 10.99 88 427892 8021 79308387
Renal cancer 17.48 10.99 24 427956 12202 79304206
Histoplasmosis 17.47 10.99 39 427941 2326 79314082
Infectious crystalline keratopathy 17.43 10.99 6 427974 17 79316391
Oral disorder 17.35 10.99 103 427877 9992 79306416
Extradural abscess 17.34 10.99 30 427950 1482 79314926
Hypercholesterolaemia 17.32 10.99 195 427785 22900 79293508
Infected seroma 17.26 10.99 9 427971 87 79316321
Extra dose administered 17.26 10.99 12 427968 8403 79308005
Anticoagulation drug level increased 17.25 10.99 21 427959 750 79315658
Temperature regulation disorder 17.22 10.99 5 427975 5848 79310560
Anaphylactoid reaction 17.16 10.99 4 427976 5418 79310990
Hypoaesthesia oral 17.09 10.99 31 427949 14093 79302315
Hepatotoxicity 17.04 10.99 378 427602 50974 79265434
Neck surgery 16.96 10.99 33 427947 1786 79314622
Cranial nerve injury 16.94 10.99 6 427974 19 79316389
Connective tissue disorder 16.90 10.99 28 427952 1335 79315073
Intracranial pressure increased 16.89 10.99 12 427968 8310 79308098
Procedural complication 16.89 10.99 11 427969 7972 79308436
International normalised ratio abnormal 16.84 10.99 5 427975 5763 79310645
Hereditary motor and sensory neuropathy 16.84 10.99 10 427970 127 79316281
Squamous cell carcinoma of skin 16.80 10.99 31 427949 14002 79302406
Hallucinations, mixed 16.77 10.99 8 427972 6891 79309517
Cerebral haematoma 16.73 10.99 11 427969 7931 79308477
Blood disorder 16.70 10.99 12 427968 8261 79308147
Petit mal epilepsy 16.66 10.99 5 427975 5722 79310686
Skin haemorrhage 16.65 10.99 24 427956 11957 79304451
Eosinophilic pneumonia 16.65 10.99 4 427976 5306 79311102
Herpes simplex viraemia 16.64 10.99 16 427964 435 79315973
Rhinitis 16.60 10.99 34 427946 14773 79301635
Back injury 16.59 10.99 105 427875 10418 79305990
Tension headache 16.57 10.99 9 427971 7202 79309206
Symptom masked 16.50 10.99 28 427952 1362 79315046
Cyst 16.49 10.99 129 427851 13711 79302697
Clostridium test positive 16.45 10.99 7 427973 6447 79309961
Coronary artery bypass 16.39 10.99 6 427974 6056 79310352
Renal cyst 16.38 10.99 34 427946 14698 79301710
Infusion site pain 16.37 10.99 32 427948 14144 79302264
Skin discolouration 16.36 10.99 141 427839 40893 79275515
Endophthalmitis 16.33 10.99 7 427973 6421 79309987
Haemorrhoidal haemorrhage 16.33 10.99 8 427972 6787 79309621
Internal haemorrhage 16.33 10.99 14 427966 8819 79307589
Intrauterine infection 16.32 10.99 8 427972 67 79316341
Chronic sinusitis 16.29 10.99 28 427952 12998 79303410
Embolic stroke 16.27 10.99 11 427969 7815 79308593
Aplasia pure red cell 16.20 10.99 11 427969 7799 79308609
Paronychia 16.19 10.99 11 427969 7797 79308611
Brain herniation 16.18 10.99 10 427970 7453 79308955
Skin irritation 16.14 10.99 22 427958 11218 79305190
Allergy to chemicals 16.06 10.99 40 427940 2562 79313846
Blood culture positive 16.03 10.99 13 427967 8416 79307992
Bronchopleural fistula 16.02 10.99 19 427961 660 79315748
Complement factor C4 decreased 16.00 10.99 14 427966 336 79316072
Spinal fusion surgery 15.95 10.99 63 427917 5175 79311233
Mean cell haemoglobin decreased 15.94 10.99 71 427909 6153 79310255
Lacunar infarction 15.93 10.99 6 427974 5951 79310457
Expired product administered 15.92 10.99 9 427971 7042 79309366
Blood pH decreased 15.89 10.99 3 427977 4708 79311700
Skin abrasion 15.87 10.99 30 427950 13426 79302982
Hyperreflexia 15.86 10.99 13 427967 8372 79308036
Pneumonia bacterial 15.83 10.99 52 427928 19279 79297129
Restless legs syndrome 15.81 10.99 55 427925 20037 79296371
Muscle haemorrhage 15.79 10.99 7 427973 6293 79310115
Sinus node dysfunction 15.77 10.99 11 427969 7690 79308718
Viral infection 15.76 10.99 151 427829 42865 79273543
Rheumatoid factor quantitative increased 15.73 10.99 5 427975 10 79316398
Eye movement disorder 15.68 10.99 12 427968 7999 79308409
Lower limb fracture 15.63 10.99 192 427788 23023 79293385
Affective disorder 15.61 10.99 13 427967 8306 79308102
Atrioventricular block second degree 15.57 10.99 10 427970 7302 79309106
Carotid artery occlusion 15.56 10.99 11 427969 7636 79308772
Localised oedema 15.45 10.99 12 427968 7940 79308468
Injection site haemorrhage 15.44 10.99 87 427893 27783 79288625
Gingival hyperpigmentation 15.41 10.99 5 427975 11 79316397
Disseminated strongyloidiasis 15.34 10.99 12 427968 245 79316163
Skin burning sensation 15.29 10.99 30 427950 13242 79303166
Nerve block 15.27 10.99 19 427961 694 79315714
Pseudomonal sepsis 15.25 10.99 7 427973 6167 79310241
Localised infection 15.25 10.99 285 427695 37290 79279118
Venoocclusive disease 15.24 10.99 3 427977 4570 79311838
Lupus enteritis 15.22 10.99 7 427973 50 79316358
Lung adenocarcinoma 15.12 10.99 12 427968 7852 79308556
Pneumonia cytomegaloviral 15.08 10.99 4 427976 4965 79311443
Complement factor C3 decreased 15.07 10.99 14 427966 364 79316044
Multiple-drug resistance 15.06 10.99 15 427965 8793 79307615
Neoplasm 15.04 10.99 16 427964 9100 79307308
Muscle tightness 15.04 10.99 29 427951 12885 79303523
Performance status decreased 15.00 10.99 7 427973 6106 79310302
Diffuse idiopathic skeletal hyperostosis 14.99 10.99 7 427973 52 79316356
Blood thyroid stimulating hormone increased 14.97 10.99 18 427962 9690 79306718
Forced expiratory volume decreased 14.92 10.99 12 427968 7802 79308606
Carotid artery stenosis 14.87 10.99 15 427965 8743 79307665
Atrial tachycardia 14.86 10.99 10 427970 7123 79309285
Nocturia 14.85 10.99 32 427948 13649 79302759
Persecutory delusion 14.81 10.99 4 427976 4905 79311503
Arthritis bacterial 14.79 10.99 92 427888 9074 79307334
Speech sound disorder 14.77 10.99 7 427973 54 79316354
Portal hypertension 14.76 10.99 10 427970 7098 79309310
Dermatitis exfoliative 14.75 10.99 22 427958 10807 79305601
Clinical trial participant 14.71 10.99 9 427971 121 79316287
Neutrophil/lymphocyte ratio increased 14.71 10.99 4 427976 3 79316405
Coronary arterial stent insertion 14.70 10.99 7 427973 6037 79310371
Sleep terror 14.70 10.99 3 427977 4455 79311953
Oxygen saturation decreased 14.70 10.99 555 427425 128492 79187916
External ear disorder 14.69 10.99 8 427972 85 79316323
Overwork 14.66 10.99 7 427973 55 79316353
Humerus fracture 14.65 10.99 17 427963 9296 79307112
Atelectasis 14.64 10.99 107 427873 32150 79284258
Foetal growth restriction 14.61 10.99 34 427946 2085 79314323
Eye pain 14.60 10.99 130 427850 37448 79278960
Brain neoplasm 14.59 10.99 6 427974 5640 79310768
Larynx irritation 14.59 10.99 9 427971 123 79316285
Dactylitis 14.58 10.99 40 427940 2717 79313691
Ventricular hypokinesia 14.53 10.99 17 427963 9262 79307146
Blood lactic acid increased 14.52 10.99 29 427951 12715 79303693
Ossicle disorder 14.49 10.99 6 427974 32 79316376
Varices oesophageal 14.48 10.99 7 427973 5984 79310424
Throat tightness 14.46 10.99 89 427891 27818 79288590
Hyperlactacidaemia 14.37 10.99 6 427974 5589 79310819
Antinuclear antibody 14.35 10.99 15 427965 452 79315956
Fundoscopy abnormal 14.34 10.99 7 427973 58 79316350
Disability assessment scale score increased 14.31 10.99 46 427934 3412 79312996
Erythematotelangiectatic rosacea 14.31 10.99 5 427975 15 79316393
Cytomegalovirus test positive 14.30 10.99 7 427973 5940 79310468
Haematocrit decreased 14.29 10.99 237 427743 61075 79255333
Blood bicarbonate decreased 14.27 10.99 5 427975 5186 79311222
Gastrointestinal necrosis 14.24 10.99 6 427974 5559 79310849
Heavy menstrual bleeding 14.21 10.99 34 427946 13977 79302431
Product administered to patient of inappropriate age 14.19 10.99 6 427974 5547 79310861
Andersen-Tawil syndrome 14.18 10.99 4 427976 4 79316404
Drug dependence 14.13 10.99 302 427678 40467 79275941
Dermatitis bullous 14.11 10.99 35 427945 14210 79302198
Infusion site erythema 14.11 10.99 18 427962 9442 79306966
Blood creatine increased 14.09 10.99 18 427962 9437 79306971
Facial paresis 14.07 10.99 6 427974 5520 79310888
Metastases to spine 14.07 10.99 3 427977 4321 79312087
Eructation 14.06 10.99 23 427957 10886 79305522
Pseudomonas infection 14.02 10.99 61 427919 20842 79295566
Food intolerance 13.99 10.99 49 427931 3799 79312609
Vaginal haematoma 13.98 10.99 9 427971 133 79316275
Endocarditis 13.98 10.99 22 427958 10575 79305833
Osteosclerosis 13.95 10.99 50 427930 3921 79312487
Injury 13.92 10.99 528 427452 76968 79239440
Epigastric discomfort 13.85 10.99 81 427899 7815 79308593
Compartment syndrome 13.79 10.99 5 427975 5077 79311331
DNA antibody 13.78 10.99 6 427974 37 79316371
Arterial occlusive disease 13.78 10.99 15 427965 8441 79307967
Urine analysis abnormal 13.77 10.99 9 427971 6511 79309897
Diastolic dysfunction 13.74 10.99 23 427957 10788 79305620
Human anti-human antibody test 13.74 10.99 14 427966 409 79315999
Escherichia infection 13.72 10.99 50 427930 17967 79298441
Hepatorenal syndrome 13.72 10.99 3 427977 4246 79312162
Laryngeal oedema 13.72 10.99 14 427966 8115 79308293
Herpes zoster reactivation 13.57 10.99 10 427970 186 79316222
Autonomic nervous system imbalance 13.54 10.99 4 427976 4626 79311782
Hypertensive heart disease 13.52 10.99 3 427977 4203 79312205
Intestinal perforation 13.51 10.99 48 427932 17378 79299030
Thyroid disorder 13.49 10.99 125 427855 13954 79302454
Ganglioneuroma 13.48 10.99 9 427971 142 79316266
Cardiac tamponade 13.47 10.99 18 427962 9258 79307150
Obstruction 13.45 10.99 4 427976 4606 79311802
Abdominal pain upper 13.43 10.99 1385 426595 222434 79093974
Normochromic normocytic anaemia 13.39 10.99 13 427967 7714 79308694
Euphoric mood 13.39 10.99 13 427967 7713 79308695
Affect lability 13.36 10.99 25 427955 11234 79305174
Oral discomfort 13.35 10.99 94 427886 9666 79306742
Mitral valve incompetence 13.33 10.99 94 427886 28471 79287937
Head discomfort 13.32 10.99 37 427943 14465 79301943
Mean cell haemoglobin concentration decreased 13.31 10.99 4 427976 4575 79311833
Ischaemic cardiomyopathy 13.27 10.99 13 427967 7682 79308726
Transient hypogammaglobulinaemia of infancy 13.27 10.99 6 427974 41 79316367
Autoimmune hepatitis 13.26 10.99 27 427953 11756 79304652
Tearfulness 13.24 10.99 8 427972 6037 79310371
Disease complication 13.16 10.99 5 427975 4932 79311476
Bacterial infection 13.14 10.99 106 427874 31174 79285234
Iodine allergy 13.06 10.99 16 427964 575 79315833
Product storage error 13.05 10.99 44 427936 16182 79300226
Caesarean section 13.05 10.99 30 427950 12505 79303903
Bone density increased 13.03 10.99 19 427961 810 79315598
Pericardial haemorrhage 12.94 10.99 4 427976 4491 79311917
Urine abnormality 12.93 10.99 15 427965 8204 79308204
Enterococcal infection 12.91 10.99 42 427938 15618 79300790
Respiratory syncytial virus infection 12.90 10.99 19 427961 9383 79307025
Sneezing 12.87 10.99 58 427922 19625 79296783
Papulopustular rosacea 12.85 10.99 5 427975 22 79316386
Scleroderma renal crisis 12.85 10.99 16 427964 585 79315823
Protein total decreased 12.85 10.99 18 427962 9074 79307334
Oral herpes 12.85 10.99 213 427767 27241 79289167
Initial insomnia 12.82 10.99 11 427969 6927 79309481
Synovial disorder 12.79 10.99 31 427949 1952 79314456
Wound dehiscence 12.76 10.99 10 427970 6585 79309823
Haematocrit increased 12.72 10.99 3 427977 4031 79312377
Mean cell volume increased 12.72 10.99 9 427971 6244 79310164
Vulvovaginal exfoliation 12.70 10.99 3 427977 0 79316408
Alcohol use 12.70 10.99 5 427975 4826 79311582
Lupus pancreatitis 12.70 10.99 3 427977 0 79316408
Escherichia bacteraemia 12.63 10.99 10 427970 6552 79309856
Social avoidant behaviour 12.63 10.99 5 427975 4809 79311599
Liver transplant 12.62 10.99 4 427976 4419 79311989
Faecal calprotectin increased 12.61 10.99 7 427973 5534 79310874
Areflexia 12.58 10.99 7 427973 5527 79310881
Bursitis infective 12.58 10.99 24 427956 1280 79315128
Diabetic neuropathy 12.57 10.99 9 427971 6207 79310201
Choking 12.57 10.99 29 427951 12072 79304336
Adjustment disorder 12.56 10.99 3 427977 3997 79312411
Aortic stenosis 12.54 10.99 13 427967 7482 79308926
Blood pressure inadequately controlled 12.42 10.99 9 427971 6168 79310240
Self-medication 12.40 10.99 6 427974 5126 79311282
Metastases to peritoneum 12.39 10.99 4 427976 4368 79312040
Cardiopulmonary failure 12.31 10.99 11 427969 6790 79309618
Application site erythema 12.31 10.99 6 427974 5104 79311304
Tongue oedema 12.30 10.99 12 427968 7105 79309303
Catheter site infection 12.29 10.99 11 427969 6784 79309624
Dysphonia 12.24 10.99 223 427757 56649 79259759
Product preparation error 12.23 10.99 8 427972 5785 79310623
Back disorder 12.22 10.99 105 427875 11473 79304935
Facial bones fracture 12.19 10.99 6 427974 5076 79311332
Episcleritis 12.19 10.99 21 427959 1034 79315374
Laryngeal pain 12.17 10.99 9 427971 6105 79310303
Meningitis streptococcal 12.14 10.99 9 427971 169 79316239
Productive cough 12.13 10.99 371 427609 87960 79228448
Respiratory alkalosis 12.12 10.99 4 427976 4307 79312101
Hyperpyrexia 12.09 10.99 9 427971 6083 79310325
Spinal X-ray abnormal 12.03 10.99 5 427975 27 79316381
Infected varicose vein 12.03 10.99 5 427975 27 79316381
Biliary obstruction 12.02 10.99 5 427975 4669 79311739
Ankylosing spondylitis 12.01 10.99 109 427871 12096 79304312
Psychiatric symptom 12.00 10.99 12 427968 7023 79309385
Insurance issue 11.99 10.99 8 427972 5725 79310683
Parosmia 11.93 10.99 12 427968 7002 79309406
Cardiac operation 11.90 10.99 6 427974 5006 79311402
Immobile 11.89 10.99 71 427909 6902 79309506
Aspergillosis oral 11.87 10.99 6 427974 54 79316354
Treatment noncompliance 11.87 10.99 203 427777 52065 79264343
Supraventricular extrasystoles 11.83 10.99 12 427968 6975 79309433
Lymphocyte percentage decreased 11.75 10.99 6 427974 4970 79311438
Visual field defect 11.73 10.99 86 427894 8959 79307449
Libido decreased 11.72 10.99 7 427973 5314 79311094
Angiocentric lymphoma 11.71 10.99 19 427961 890 79315518
Biopsy heart abnormal 11.70 10.99 4 427976 11 79316397
Arthritis salmonella 11.70 10.99 4 427976 11 79316397
Neoplasm recurrence 11.69 10.99 4 427976 4210 79312198
Pelvic pain 11.66 10.99 35 427945 13346 79303062
Oxygen saturation abnormal 11.63 10.99 5 427975 4577 79311831
Left ventricular failure 11.62 10.99 21 427959 9560 79306848
Protein total increased 11.55 10.99 3 427977 3776 79312632
Blood urine present 11.52 10.99 67 427913 21230 79295178
Jaw fracture 11.48 10.99 39 427941 2978 79313430
Gangrene 11.46 10.99 19 427961 8945 79307463
Retinal injury 11.41 10.99 11 427969 300 79316108
Device related sepsis 11.40 10.99 10 427970 6230 79310178
Granuloma 11.40 10.99 80 427900 8217 79308191
Skin papilloma 11.40 10.99 62 427918 5824 79310584
Pneumonia pseudomonal 11.39 10.99 9 427971 5902 79310506
Splenomegaly 11.38 10.99 65 427915 20689 79295719
Pulmonary function test abnormal 11.38 10.99 4 427976 4140 79312268
Soft tissue swelling 11.37 10.99 25 427955 1476 79314932
Contraindication to medical treatment 11.34 10.99 23 427957 1283 79315125
Nail operation 11.33 10.99 16 427964 662 79315746
Rebound effect 11.33 10.99 72 427908 7154 79309254
Abdominal wall haematoma 11.32 10.99 6 427974 4867 79311541
Lung neoplasm malignant 11.30 10.99 95 427885 27697 79288711
Clonus 11.29 10.99 12 427968 6828 79309580
Chronic lymphocytic leukaemia 11.29 10.99 6 427974 4860 79311548
Blood immunoglobulin E increased 11.27 10.99 9 427971 5873 79310535
Oral surgery 11.27 10.99 21 427959 1100 79315308
Metabolic alkalosis 11.23 10.99 5 427975 4484 79311924
Wound secretion 11.21 10.99 10 427970 6178 79310230
Venous thrombosis 11.18 10.99 13 427967 7103 79309305
Joint space narrowing 11.15 10.99 16 427964 672 79315736
Serositis 11.14 10.99 18 427962 840 79315568
Mass 11.12 10.99 143 427837 17329 79299079
Prescription drug used without a prescription 11.12 10.99 4 427976 4081 79312327
Myositis 11.07 10.99 59 427921 19109 79297299
Neuralgia 11.07 10.99 120 427860 33264 79283144
Phlebitis 11.03 10.99 19 427961 8811 79307597
Blood sodium increased 11.01 10.99 6 427974 4792 79311616
Retinal depigmentation 11.00 10.99 11 427969 314 79316094
Acute cutaneous lupus erythematosus 11.00 10.99 12 427968 380 79316028
Multiple system atrophy 11.00 10.99 12 427968 380 79316028

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC P01BA02 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
ANTIMALARIALS
Aminoquinolines
FDA EPC N0000175482 Antimalarial
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000962 Antimalarials
MeSH PA D000977 Antiparasitic Agents
MeSH PA D000981 Antiprotozoal Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D004791 Enzyme Inhibitors
CHEBI has role CHEBI:35842 anti-rheumatic drugs
CHEBI has role CHEBI:38068 antimalarials
CHEBI has role CHEBI:50177 dermatologic agent
CHEBI has role CHEBI:149553 anticoronaviral drug
FDA EPC N0000175713 Antirheumatic Agent

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ovale malaria indication 19341001 DOID:12919
Vivax malaria indication 27052006 DOID:12978
Quartan malaria indication 27618009 DOID:14324
Systemic lupus erythematosus indication 55464009 DOID:9074
Falciparum malaria indication 62676009 DOID:14067
Rheumatoid arthritis indication 69896004 DOID:7148
Discoid lupus erythematosus indication 200938002
Plasmodium Malariae Malaria Prevention indication
Plasmodium Ovale Malaria Prevention indication
Malaria Prevention indication
Plasmodium Falciparum Malaria Prevention indication
Vasculitis of the skin off-label use 53312001
Porphyria cutanea tarda off-label use 61860000 DOID:3132
Q fever endocarditis off-label use 95890006
Coronavirus infection off-label use 186747009
Polymorphic light eruption off-label use 238525001
Juvenile rheumatoid arthritis off-label use 410795001
Hypercalcemia associated with Sarcoidosis off-label use
Alcoholism contraindication 7200002
Psoriasis contraindication 9014002 DOID:8893
Visual field defect contraindication 12184005
Retinal disorder contraindication 29555009 DOID:5679
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Neutropenic disorder contraindication 303011007 DOID:1227
Disorder of macula of retina contraindication 312999006
Disorder of eye contraindication 371405004 DOID:5614
Visual impairment contraindication 397540003
Porphyria contraindication 418470004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.51 Basic
pKa2 7.83 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Toll-like receptor 7 Membrane receptor ANTAGONIST IC50 5.56 IUPHAR CHEMBL
Toll-like receptor 9 Membrane receptor ANTAGONIST IC50 7.10 IUPHAR CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 4.14 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Ki 4.81 CHEMBL
Muscarinic acetylcholine receptor M2 GPCR Ki 5.98 DRUG MATRIX
Muscarinic acetylcholine receptor M3 GPCR Ki 5.32 CHEMBL
Muscarinic acetylcholine receptor M4 GPCR Ki 5.26 CHEMBL
Muscarinic acetylcholine receptor M5 GPCR Ki 4.70 CHEMBL
Alpha-2C adrenergic receptor GPCR Ki 4.80 CHEMBL
Hemoglobin subunit alpha Secreted WOMBAT-PK
Alpha-1D adrenergic receptor GPCR Ki 5.63 DRUG MATRIX
Transmembrane protein 97 Enzyme Ki 6 CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 5.19 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.90 CHEMBL
Genome polyprotein Unclassified Ki 4.04 CHEMBL

External reference:

IDSource
4019780 VUID
N0000147871 NUI
D02114 KEGG_DRUG
747-36-4 SECONDARY_CAS_RN
4018253 VANDF
4019780 VANDF
C0020336 UMLSCUI
CHEBI:5801 CHEBI
CHEMBL1535 ChEMBL_ID
DB01611 DRUGBANK_ID
CHEMBL1690 ChEMBL_ID
D006886 MESH_DESCRIPTOR_UI
3652 PUBCHEM_CID
7198 IUPHAR_LIGAND_ID
796 INN_ID
4QWG6N8QKH UNII
153972 RXNORM
15082 MMSL
1645 MMSL
4852 MMSL
d00817 MMSL
002949 NDDF
004906 NDDF
13502005 SNOMEDCT_US
373540008 SNOMEDCT_US
83490000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0093-2401 TABLET, FILM COATED 200 mg ORAL ANDA 25 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0093-2401 TABLET, FILM COATED 200 mg ORAL ANDA 25 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0373 TABLET, FILM COATED 200 mg ORAL ANDA 27 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0373 TABLET, FILM COATED 200 mg ORAL ANDA 27 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0591-3041 TABLET, FILM COATED 200 mg ORAL ANDA 25 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8374 TABLET, FILM COATED 200 mg ORAL ANDA 10 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8401 TABLET 200 mg ORAL ANDA 30 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8401 TABLET 200 mg ORAL ANDA 30 sections
Hydroxychloroquine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8459 TABLET, FILM COATED 200 mg ORAL ANDA 25 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0781-5994 TABLET, FILM COATED 200 mg ORAL ANDA 25 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0781-5994 TABLET, FILM COATED 200 mg ORAL ANDA 25 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0781-5994 TABLET, FILM COATED 200 mg ORAL ANDA 25 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6884 TABLET, FILM COATED 200 mg ORAL ANDA 14 sections
HYDROXYCHLOROQUINE SULFATE HUMAN PRESCRIPTION DRUG LABEL 1 0904-7046 TABLET 200 mg ORAL ANDA 17 sections
HYDROXYCHLOROQUINE SULFATE HUMAN PRESCRIPTION DRUG LABEL 1 0904-7046 TABLET 200 mg ORAL ANDA 17 sections
Hydroxychloroquine Sulfate Human Prescription Drug Label 1 16571-112 TABLET, FILM COATED 200 mg ORAL ANDA 25 sections
Hydroxychloroquine Sulfate Human Prescription Drug Label 1 16571-687 TABLET, FILM COATED 200 mg ORAL ANDA 27 sections
Hydroxychloroquine Sulfate Human Prescription Drug Label 1 16571-687 TABLET, FILM COATED 200 mg ORAL ANDA 27 sections
Hydroxychloroquine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16714-110 TABLET, FILM COATED 200 mg ORAL ANDA 26 sections
Hydroxychloroquine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16714-110 TABLET, FILM COATED 200 mg ORAL ANDA 26 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16714-753 TABLET, FILM COATED 200 mg ORAL ANDA 25 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16714-753 TABLET, FILM COATED 200 mg ORAL ANDA 25 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16729-485 TABLET 200 mg ORAL ANDA 26 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16729-485 TABLET 200 mg ORAL ANDA 26 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16729-561 TABLET 100 mg ORAL ANDA 26 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16729-561 TABLET 100 mg ORAL ANDA 26 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16729-562 TABLET 300 mg ORAL ANDA 26 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16729-562 TABLET 300 mg ORAL ANDA 26 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16729-563 TABLET 400 mg ORAL ANDA 26 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16729-563 TABLET 400 mg ORAL ANDA 26 sections