hydroxychloroquine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
quinoline derivatives 1395 118-42-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hydroxychloroquine
  • hydroxychloroquine sulfate
  • oxichloroquine
  • oxychlorochin
  • oxychloroquine
A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970). In March 2020, FDA issued an emergency use authorization (EUA) for hydroxychloroquine and chloroquine in the treatment of COVID-10. EUA was revoked in June 2020. Data from various published randomized, controlled clinical trials and retrospective, cohort studies have not substantiated initial reports of efficacy of 4-aminoquinoline antimalarials for treatment of COVID-19.
  • Molecular weight: 335.88
  • Formula: C18H26ClN3O
  • CLOGP: 4.12
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 48.39
  • ALOGS: -4.11
  • ROTB: 9
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.52 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 20 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 27 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 29.77 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 74 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 700 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 11 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.57 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 850 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT2,AKT3,AXL,BRAF,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,MAP3K21,MAP3K7,MAPK10,MAPK7,MET,NTRK2,PDK2,PDK4,PIM2,PRKDC,SIK2,SIK3,STK33,TEK,TGFBR1 32
kinase-selectivity-class AXL,EIF2AK3 2
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 4.375 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 High 1
rat-kpuu-brain Rat brain Kpuu 0.037 % High 1

Approvals:

DateAgencyCompanyOrphan
April 18, 1955 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 4793.96 10.88 23191 721873 1361107 88522276
Drug intolerance 4072.73 10.88 10359 734705 437232 89446151
Contraindicated product administered 3147.52 10.88 7637 737427 312502 89570881
Synovitis 2802.40 10.88 7445 737619 322307 89561076
Joint swelling 2774.69 10.88 9760 735304 493540 89389843
Treatment failure 2453.02 10.88 6734 738330 297194 89586189
Systemic lupus erythematosus 2298.17 10.88 7364 737700 354532 89528851
Arthropathy 2090.36 10.88 7189 737875 359053 89524330
Rheumatoid arthritis 2053.98 10.88 7100 737964 355514 89527869
Therapeutic product effect decreased 2041.37 10.88 5948 739116 271623 89611760
Pemphigus 1875.82 10.88 6429 738635 320435 89562948
Abdominal discomfort 1588.74 10.88 7937 737127 469391 89413992
Glossodynia 1560.89 10.88 5993 739071 315786 89567597
Death 1520.00 10.88 938 744126 455613 89427770
Hand deformity 1507.05 10.88 5604 739460 290758 89592625
Swelling 1456.52 10.88 7056 738008 412002 89471381
Alopecia 1429.37 10.88 7915 737149 487156 89396227
Acute kidney injury 1174.57 10.88 583 744481 319804 89563579
Constipation 1133.83 10.88 443 744621 279952 89603431
Arthralgia 1095.04 10.88 10471 734593 768051 89115332
Anaemia 1061.42 10.88 809 744255 351993 89531390
Anti-cyclic citrullinated peptide antibody positive 1047.38 10.88 4282 740782 232151 89651232
Wound 993.23 10.88 5020 740044 297960 89585423
Pain 966.80 10.88 12452 732612 983889 88899494
Hepatic enzyme increased 950.64 10.88 5632 739432 355104 89528279
Musculoskeletal stiffness 938.33 10.88 4865 740199 291667 89591716
Pericarditis 918.48 10.88 4523 740541 265628 89617755
Rheumatoid factor positive 906.76 10.88 3288 741776 168362 89715021
Febrile neutropenia 873.21 10.88 130 744934 158219 89725164
C-reactive protein abnormal 815.37 10.88 2603 742461 124826 89758557
Dehydration 784.48 10.88 308 744756 194139 89689244
Red blood cell sedimentation rate abnormal 773.88 10.88 975 744089 23229 89860154
Hypotension 750.89 10.88 943 744121 324454 89558929
Malignant neoplasm progression 737.77 10.88 33 745031 106837 89776546
Completed suicide 721.99 10.88 155 744909 144903 89738480
Discomfort 711.76 10.88 4267 740797 270068 89613315
Hyponatraemia 704.04 10.88 124 744940 133414 89749969
Peripheral swelling 698.37 10.88 5789 739275 407317 89476066
Duodenal ulcer perforation 685.31 10.88 3610 741454 217678 89665705
Hypersensitivity 671.70 10.88 6185 738879 448492 89434891
Helicobacter infection 646.62 10.88 3618 741446 223232 89660151
Drug interaction 636.81 10.88 802 744262 275651 89607732
Product dose omission issue 617.50 10.88 900 744164 290787 89592596
Neutropenia 605.79 10.88 573 744491 224331 89659052
Tremor 605.73 10.88 250 744814 152923 89730460
Condition aggravated 595.77 10.88 7492 737572 588053 89295330
Somnolence 595.10 10.88 506 744558 208578 89674805
Seizure 590.94 10.88 257 744807 152372 89731011
Folliculitis 589.51 10.88 3270 741794 201083 89682300
Maternal exposure during pregnancy 569.30 10.88 4972 740092 355091 89528292
Muscle injury 566.90 10.88 2911 742153 173743 89709640
Toxicity to various agents 563.63 10.88 936 744128 286910 89596473
Psoriatic arthropathy 558.19 10.88 3498 741566 224837 89658546
Gastrointestinal disorder 556.80 10.88 3816 741248 252871 89630512
Impaired healing 547.30 10.88 3547 741517 230652 89652731
Ill-defined disorder 545.58 10.88 2977 742087 181914 89701469
Infusion related reaction 544.56 10.88 5526 739538 411254 89472129
Product use issue 532.03 10.88 4576 740488 325343 89558040
Lower respiratory tract infection 526.32 10.88 3697 741367 246962 89636421
Drug hypersensitivity 525.41 10.88 5974 739090 457635 89425748
Irritable bowel syndrome 522.68 10.88 3203 741861 204245 89679138
Therapeutic product effect incomplete 519.33 10.88 3042 742022 190854 89692529
C-reactive protein increased 517.40 10.88 2894 742170 178495 89704888
Red blood cell sedimentation rate increased 509.86 10.88 1667 743397 80928 89802455
Drug abuse 494.37 10.88 51 745013 82296 89801087
Thrombocytopenia 492.65 10.88 594 744470 208131 89675252
Infection 487.31 10.88 4831 740233 357263 89526120
Rash 478.70 10.88 9189 735875 786911 89096472
Sleep disorder due to general medical condition, insomnia type 470.18 10.88 2201 742863 126493 89756890
Fall 462.94 10.88 2211 742853 479599 89403784
Disease progression 450.52 10.88 375 744689 156240 89727143
Blister 446.69 10.88 3604 741460 251394 89631989
Atrial fibrillation 434.79 10.88 281 744783 133330 89750053
Urinary tract infection 429.95 10.88 1196 743868 304436 89578947
Loss of personal independence in daily activities 428.32 10.88 2231 742833 133874 89749509
Depressed level of consciousness 417.10 10.88 53 745011 72731 89810652
Pulmonary embolism 404.50 10.88 291 744773 130529 89752854
Mobility decreased 396.22 10.88 3463 741601 247271 89636112
Neutrophil count decreased 395.91 10.88 58 745006 71474 89811909
Platelet count decreased 392.66 10.88 329 744735 136640 89746743
Bradycardia 392.65 10.88 102 744962 83745 89799638
Dyspnoea 389.14 10.88 5011 740053 875944 89007439
Retinal toxicity 385.31 10.88 202 744862 1220 89882163
Hyperhidrosis 385.13 10.88 332 744732 135973 89747410
White blood cell count decreased 373.02 10.88 496 744568 166613 89716770
Overdose 363.47 10.88 457 744607 157252 89726131
Inflammation 362.36 10.88 2613 742451 175979 89707404
Coma 358.50 10.88 79 744985 72553 89810830
Renal failure 358.24 10.88 329 744735 130678 89752705
Balance disorder 357.81 10.88 175 744889 96905 89786478
Fibromyalgia 357.68 10.88 2909 742155 203360 89680023
Cerebrovascular accident 355.00 10.88 296 744768 123237 89760146
Gastrointestinal haemorrhage 353.98 10.88 149 744915 90099 89793284
Cognitive disorder 343.58 10.88 75 744989 69332 89814051
Sepsis 341.39 10.88 596 744468 179218 89704165
Multiple sclerosis relapse 336.86 10.88 24 745040 52281 89831102
Suicide attempt 333.98 10.88 102 744962 75297 89808086
Rheumatic fever 332.65 10.88 2278 742786 150843 89732540
Intentional overdose 332.63 10.88 178 744886 93656 89789727
Cough 329.06 10.88 1737 743327 367225 89516158
Chest discomfort 326.15 10.88 394 744670 137971 89745412
Agitation 319.24 10.88 79 744985 67019 89816364
Stomatitis 314.30 10.88 3548 741516 271150 89612233
Blood iron abnormal 311.45 10.88 261 744803 3759 89879624
Sedation 310.52 10.88 22 745042 48149 89835234
Neoplasm progression 306.13 10.88 14 745050 44472 89838911
Blood cholesterol increased 301.96 10.88 2821 742243 205191 89678192
Diarrhoea 298.91 10.88 5684 739380 933506 88949877
Hallucination 298.04 10.88 86 744978 65873 89817510
Osteoarthritis 297.04 10.88 2680 742384 193050 89690333
Lactic acidosis 295.90 10.88 34 745030 50429 89832954
Knee arthroplasty 294.49 10.88 1410 743654 81772 89801611
Dysphagia 294.09 10.88 293 744771 111985 89771398
Tachycardia 292.63 10.88 530 744534 157143 89726240
Pulmonary fibrosis 291.74 10.88 1693 743371 105810 89777573
Cardio-respiratory arrest 289.61 10.88 80 744984 63060 89820323
Hyperkalaemia 287.53 10.88 88 744976 64876 89818507
Retinopathy 287.43 10.88 236 744828 3298 89880085
Syncope 286.73 10.88 403 744661 132260 89751123
Neuropathy peripheral 284.35 10.88 428 744636 136542 89746841
Off label use 282.83 10.88 11402 733662 1090850 88792533
Epistaxis 282.45 10.88 175 744889 84950 89798433
Blood glucose increased 281.41 10.88 222 744842 95024 89788359
Anxiety 279.67 10.88 1452 743612 308320 89575063
Rheumatoid nodule 279.06 10.88 553 744511 19613 89863770
Sinusitis 271.66 10.88 4143 740921 338945 89544438
Cardiac arrest 270.10 10.88 278 744786 104657 89778726
Haemoglobin decreased 268.19 10.88 582 744482 161374 89722009
Palpitations 267.02 10.88 445 744619 136283 89747100
Type 2 diabetes mellitus 265.88 10.88 2697 742367 200547 89682836
Musculoskeletal pain 264.52 10.88 2354 742710 168897 89714486
Device expulsion 259.76 10.88 20 745044 40866 89842517
Liver injury 259.56 10.88 2337 742727 168230 89715153
Swollen joint count increased 257.46 10.88 1681 743383 109525 89773858
Vision blurred 256.81 10.88 317 744747 109976 89773407
Feeling abnormal 256.72 10.88 626 744438 166609 89716774
Rhabdomyolysis 254.48 10.88 55 745009 51201 89832182
Hip arthroplasty 254.18 10.88 1270 743794 74938 89808445
Colitis 253.34 10.88 129 744935 69813 89813570
Serotonin syndrome 248.03 10.88 16 745048 37871 89845512
Nausea 247.16 10.88 7099 737965 1103217 88780166
Abdominal pain 244.27 10.88 2079 742985 393642 89489741
Wrong technique in product usage process 243.24 10.88 143 744921 71428 89811955
Dizziness 243.16 10.88 3397 741667 585887 89297496
Lupus nephritis 242.30 10.88 246 744818 4586 89878797
Musculoskeletal disorder 242.08 10.88 546 744518 21223 89862160
Pancytopenia 235.21 10.88 391 744673 119872 89763511
Hypoxia 234.49 10.88 153 744911 72246 89811137
Arthritis 234.25 10.88 2252 742812 165063 89718320
Joint range of motion decreased 233.93 10.88 1911 743153 133732 89749651
Haematochezia 232.21 10.88 148 744916 70765 89812618
Myalgia 230.99 10.88 706 744358 174419 89708964
Erythema 229.82 10.88 1035 744029 228211 89655172
Plasma cell myeloma 223.86 10.88 34 745030 40794 89842589
Dry skin 223.65 10.88 236 744828 87837 89795546
Bone pain 223.48 10.88 115 744949 61868 89821515
Metabolic acidosis 218.20 10.88 92 744972 55584 89827799
Injection site pain 216.67 10.88 718 744346 172981 89710402
Grip strength decreased 214.64 10.88 1400 743664 91176 89792207
Maculopathy 213.62 10.88 172 744892 2334 89881049
Respiratory failure 210.92 10.88 408 744656 118010 89765373
Hyperglycaemia 209.97 10.88 78 744986 50892 89832491
Deep vein thrombosis 208.43 10.88 268 744796 91352 89792031
Dysarthria 207.23 10.88 94 744970 54388 89828995
Blood pressure decreased 207.19 10.88 186 744878 74709 89808674
Intentional product use issue 206.40 10.88 2706 742358 214186 89669197
Disturbance in attention 206.35 10.88 65 744999 47044 89836339
Inappropriate schedule of product administration 205.99 10.88 593 744471 149340 89734043
International normalised ratio increased 205.98 10.88 66 744998 47250 89836133
Cardiac failure congestive 204.24 10.88 309 744755 98385 89784998
Dyskinesia 203.61 10.88 29 745035 36505 89846878
Hypoglycaemia 203.57 10.88 165 744899 69683 89813700
Cardiac failure 203.19 10.88 368 744696 109128 89774255
Nasopharyngitis 200.45 10.88 4567 740497 402537 89480846
Suicidal ideation 200.06 10.88 187 744877 73668 89809715
Deformity 199.77 10.88 359 744705 11811 89871572
Blood bilirubin increased 199.50 10.88 55 745009 43415 89839968
Impaired work ability 196.53 10.88 468 744596 18858 89864525
Pneumonia aspiration 195.14 10.88 48 745016 40892 89842491
Intentional product misuse 192.80 10.88 273 744791 89331 89794052
Palmar-plantar erythrodysaesthesia syndrome 192.23 10.88 9 745055 28014 89855369
Encephalopathy 188.11 10.88 73 744991 46371 89837012
Blood calcium decreased 185.59 10.88 17 745047 30165 89853218
Myelosuppression 183.64 10.88 106 744958 53485 89829898
Unresponsive to stimuli 183.06 10.88 44 745020 38077 89845306
Chills 182.77 10.88 520 744544 131461 89751922
Disorientation 182.58 10.88 67 744997 44047 89839336
Cytokine release syndrome 182.56 10.88 12 745052 27961 89855422
Restlessness 182.14 10.88 36 745028 35684 89847699
Melaena 179.70 10.88 34 745030 34763 89848620
Incorrect dose administered 179.42 10.88 231 744833 78699 89804684
Bone erosion 176.37 10.88 883 744181 52138 89831245
Haemorrhage 175.99 10.88 186 744878 69183 89814200
Aphasia 175.54 10.88 66 744998 42746 89840637
Sopor 175.51 10.88 6 745058 24638 89858745
Swollen tongue 175.24 10.88 79 744985 45877 89837506
Hypomagnesaemia 175.02 10.88 39 745025 35549 89847834
Skin exfoliation 173.53 10.88 181 744883 67732 89815651
Asthenia 172.36 10.88 3220 741844 530531 89352852
Pulmonary oedema 170.74 10.88 155 744909 61925 89821458
Urinary retention 169.07 10.88 50 745014 37694 89845689
Vertigo 168.52 10.88 195 744869 69616 89813767
Multiple organ dysfunction syndrome 168.09 10.88 188 744876 68148 89815235
Metastases to bone 166.28 10.88 11 745053 25494 89857889
Cerebral haemorrhage 165.47 10.88 40 745024 34482 89848901
Accidental exposure to product 164.43 10.88 71 744993 42295 89841088
Respiratory arrest 162.83 10.88 37 745027 33274 89850109
Flushing 162.76 10.88 299 744765 88192 89795191
Dysgeusia 162.31 10.88 117 744947 52443 89830940
Back pain 161.75 10.88 1746 743318 315429 89567954
Pneumonia 161.71 10.88 4002 741062 634057 89249326
Vomiting 161.04 10.88 5096 739968 783197 89100186
Swelling face 160.45 10.88 263 744801 81089 89802294
Hepatic function abnormal 159.40 10.88 91 744973 46197 89837186
Generalised tonic-clonic seizure 158.61 10.88 45 745019 34858 89848525
Drug withdrawal syndrome 157.29 10.88 24 745040 28699 89854684
Deafness transitory 156.95 10.88 132 744932 1911 89881472
Irritability 156.56 10.88 49 745015 35613 89847770
Blood parathyroid hormone decreased 155.96 10.88 324 744740 11892 89871491
Hypokalaemia 155.35 10.88 554 744510 130562 89752821
Paraesthesia oral 155.08 10.88 35 745029 31624 89851759
Tenosynovitis 154.93 10.88 359 744705 14208 89869175
Pleural effusion 154.50 10.88 442 744622 111549 89771834
Oedema peripheral 154.11 10.88 1366 743698 256549 89626834
Lethargy 153.88 10.88 175 744889 62964 89820419
Granuloma skin 152.77 10.88 297 744767 10383 89873000
Mucosal inflammation 152.46 10.88 149 744915 57476 89825907
Hepatic failure 151.94 10.88 68 744996 39660 89843723
Adverse event 151.47 10.88 1554 743510 115864 89767519
Panniculitis 151.23 10.88 354 744710 14104 89869279
Osteonecrosis of jaw 151.02 10.88 66 744998 39037 89844346
Intentional self-injury 150.76 10.88 29 745035 29305 89854078
Sleep disorder 148.76 10.88 2371 742693 195659 89687724
Device dislocation 147.95 10.88 38 745026 31444 89851939
Injury 147.93 10.88 2362 742702 194987 89688396
Contusion 147.09 10.88 2891 742173 248325 89635058
Cholelithiasis 145.71 10.88 130 744934 52376 89831007
Disability 145.14 10.88 692 744372 40053 89843330
Full blood count decreased 145.07 10.88 33 745031 29656 89853727
Metastases to liver 142.82 10.88 31 745033 28776 89854607
Mental status changes 142.54 10.88 96 744968 44583 89838800
Myocardial infarction 142.00 10.88 424 744640 105548 89777835
Night sweats 141.60 10.88 1651 743413 127115 89756268
Hemiparesis 140.98 10.88 43 745021 31776 89851607
Altered state of consciousness 140.82 10.88 42 745022 31490 89851893
Joint stiffness 140.20 10.88 1110 743954 76932 89806451
Polyarthritis 139.98 10.88 399 744665 17951 89865432
Blood alkaline phosphatase increased 139.57 10.88 114 744950 47965 89835418
Sciatica 138.59 10.88 1358 743706 100024 89783359
Facet joint syndrome 137.49 10.88 1324 743740 97065 89786318
Jaundice 136.93 10.88 48 745016 32469 89850914
Orthostatic hypotension 135.97 10.88 88 744976 41739 89841644
Macular degeneration 134.58 10.88 72 744992 37898 89845485
Emotional distress 133.69 10.88 67 744997 36595 89846788
Drug tolerance decreased 133.39 10.88 571 744493 31559 89851824
Abnormal behaviour 133.28 10.88 15 745049 22613 89860770
Respiratory distress 132.07 10.88 78 744986 38868 89844515
Haematoma 129.90 10.88 80 744984 38968 89844415
Renal impairment 129.89 10.88 438 744626 104983 89778400
Rash erythematous 129.76 10.88 209 744855 64895 89818488
Dysuria 129.31 10.88 82 744982 39319 89844064
Chronic obstructive pulmonary disease 129.18 10.88 257 744807 73572 89809811
Flatulence 129.16 10.88 91 744973 41276 89842107
Joint destruction 128.94 10.88 316 744748 12971 89870412
Coordination abnormal 128.75 10.88 13 745051 21343 89862040
Rectal haemorrhage 128.29 10.88 308 744756 82436 89800947
Obstructive airways disorder 127.92 10.88 28 745036 25841 89857542
Hepatic cytolysis 127.86 10.88 47 745017 30869 89852514
Full blood count abnormal 127.38 10.88 71 744993 36526 89846857
Blood potassium decreased 126.74 10.88 123 744941 47604 89835779
Creatinine renal clearance decreased 126.69 10.88 7 745057 18892 89864491
Lymphocyte count decreased 126.39 10.88 65 744999 34985 89848398
Drug level increased 125.77 10.88 36 745028 27726 89855657
Shoulder arthroplasty 125.56 10.88 163 744901 4003 89879380
Blood creatinine increased 123.71 10.88 423 744641 100963 89782420
Ascites 122.23 10.88 127 744937 47613 89835770
Tubulointerstitial nephritis 122.18 10.88 29 745035 25314 89858069
Upper gastrointestinal haemorrhage 121.78 10.88 21 745043 22955 89860428
Foot deformity 120.97 10.88 873 744191 58778 89824605
Fluid retention 120.53 10.88 349 744715 87742 89795641
Transient ischaemic attack 119.69 10.88 107 744957 43069 89840314
Angioedema 118.60 10.88 220 744844 64656 89818727
Muscle twitching 118.06 10.88 27 745037 24175 89859208
Pallor 117.88 10.88 67 744997 34098 89849285
Poisoning deliberate 117.45 10.88 4 745060 16482 89866901
Speech disorder 115.89 10.88 122 744942 45463 89837920
Bone marrow failure 115.82 10.88 60 745004 32161 89851222
Joint effusion 115.50 10.88 391 744673 19319 89864064
Accidental overdose 115.22 10.88 44 745020 28229 89855154
Blood urea increased 114.84 10.88 53 745011 30360 89853023
Acute myocardial infarction 113.97 10.88 73 744991 34817 89848566
Food allergy 113.66 10.88 34 745030 25444 89857939
Small intestinal obstruction 113.44 10.88 19 745045 21215 89862168
Depressed mood 113.09 10.88 148 744916 50074 89833309
Dementia 111.74 10.88 29 745035 23832 89859551
Hypervolaemia 110.52 10.88 66 744998 32691 89850692
Withdrawal syndrome 110.13 10.88 25 745039 22499 89860884
Status epilepticus 109.94 10.88 13 745051 18861 89864522
Inappropriate antidiuretic hormone secretion 109.83 10.88 15 745049 19490 89863893
Pyrexia 109.29 10.88 4381 740683 656104 89227279
Oxygen saturation decreased 108.99 10.88 483 744581 107000 89776383
Schizophrenia 108.49 10.88 3 745061 14911 89868472
Cardiac disorder 108.32 10.88 188 744876 56684 89826699
Tuberculin test positive 108.01 10.88 143 744921 3582 89879801
Circulatory collapse 107.93 10.88 35 745029 24869 89858514
Chronic kidney disease 107.88 10.88 153 744911 50038 89833345
Weight decreased 107.19 10.88 2343 742721 377567 89505816
Musculoskeletal deformity 106.99 10.88 103 744961 1795 89881588
Cholestasis 106.70 10.88 85 744979 36214 89847169
Elbow deformity 106.65 10.88 93 744971 1418 89881965
Pulmonary toxicity 106.38 10.88 269 744795 11262 89872121
Aggression 106.22 10.88 43 745021 26625 89856758
Eye pruritus 105.91 10.88 53 745011 28974 89854409
Acute myeloid leukaemia 104.82 10.88 21 745043 20619 89862764
Renal phospholipidosis 104.75 10.88 47 745017 189 89883194
Product administration error 104.60 10.88 43 745021 26380 89857003
Nodule 104.49 10.88 466 744598 26220 89857163
Neutropenic sepsis 104.35 10.88 13 745051 18117 89865266
Thrombosis 103.31 10.88 286 744778 72965 89810418
Therapeutic response decreased 102.90 10.88 1160 743904 88569 89794814
X-ray abnormal 102.86 10.88 683 744381 44741 89838642
Hot flush 102.43 10.88 209 744855 59279 89824104
Ischaemic stroke 101.80 10.88 28 745036 22138 89861245
Parkinsonism 101.68 10.88 3 745061 14062 89869321
Lip dry 101.62 10.88 1273 743791 99682 89783701
Decreased appetite 101.45 10.88 2339 742725 374201 89509182
Asthma 101.36 10.88 1391 743673 240769 89642614
Diabetic ketoacidosis 101.12 10.88 37 745027 24370 89859013
Hallucination, visual 100.88 10.88 32 745032 23060 89860323
Dyspnoea exertional 100.65 10.88 284 744780 72004 89811379
Vaginal discharge 100.54 10.88 19 745045 19445 89863938
Haematemesis 100.37 10.88 78 744986 33648 89849735
Acute respiratory failure 100.25 10.88 123 744941 42795 89840588
Female genital tract fistula 100.00 10.88 14 745050 17854 89865529
Gastritis 99.29 10.88 118 744946 41635 89841748
Arrhythmia 99.22 10.88 121 744943 42211 89841172
Acute hepatic failure 99.04 10.88 31 745033 22530 89860853
Therapy non-responder 98.97 10.88 1627 743437 135077 89748306
Device issue 98.97 10.88 60 745004 29477 89853906
Urinary incontinence 98.38 10.88 98 744966 37468 89845915
Influenza 98.19 10.88 705 744359 138559 89744824
Deep vein thrombosis postoperative 97.99 10.88 951 744113 69858 89813525
Cerebral infarction 97.89 10.88 48 745016 26548 89856835
Gait inability 97.65 10.88 1720 743344 144736 89738647
Metastases to central nervous system 97.57 10.88 14 745050 17528 89865855
Chronic sinusitis 97.07 10.88 37 745027 23765 89859618
SLE arthritis 96.92 10.88 65 744999 652 89882731
Electrolyte imbalance 96.69 10.88 37 745027 23708 89859675
Hospitalisation 96.49 10.88 636 744428 127464 89755919
Proctitis 95.44 10.88 8 745056 15251 89868132
Eczema 95.13 10.88 181 744883 52689 89830694
Gamma-glutamyltransferase increased 94.88 10.88 103 744961 37849 89845534
Product prescribing error 94.52 10.88 66 744998 30079 89853304
Myoclonus 94.27 10.88 21 745043 19147 89864236
Therapy interrupted 94.20 10.88 167 744897 49941 89833442
Liver function test increased 94.16 10.88 1090 743974 83765 89799618
Hypothyroidism 93.75 10.88 184 744880 52943 89830440
Finger deformity 93.73 10.88 525 744539 32372 89851011
Fine motor skill dysfunction 92.99 10.88 163 744901 5256 89878127
Blood pressure increased 92.85 10.88 1105 743959 196112 89687271
Diabetes mellitus inadequate control 92.84 10.88 20 745044 18664 89864719
Procedural pain 92.08 10.88 83 744981 33277 89850106
Dislocation of vertebra 91.88 10.88 780 744284 55188 89828195
Angina pectoris 91.71 10.88 112 744952 39048 89844335
Hepatocellular injury 91.33 10.88 63 745001 28895 89854488
Abdominal pain lower 90.81 10.88 69 744995 30108 89853275
Extrapyramidal disorder 90.71 10.88 13 745051 16290 89867093
Adverse drug reaction 90.52 10.88 1405 743659 115296 89768087
Bone density decreased 90.36 10.88 331 744733 17014 89866369
Respiratory depression 90.05 10.88 11 745053 15564 89867819
Hypophosphataemia 89.66 10.88 9 745055 14845 89868538
Hyperthyroidism 88.18 10.88 21 745043 18289 89865094
Neurotoxicity 88.16 10.88 33 745031 21434 89861949
Breast cancer stage III 88.08 10.88 1072 743992 83375 89800008
Obesity 87.94 10.88 1286 743778 104221 89779162
Dysphonia 87.71 10.88 248 744816 62836 89820547
Hemiplegia 87.36 10.88 14 745050 16146 89867237
Motor dysfunction 87.00 10.88 25 745039 19205 89864178
Injection site erythema 86.92 10.88 465 744599 98037 89785346
Coronary artery disease 86.58 10.88 89 744975 33534 89849849
Fatigue 86.36 10.88 10787 734277 1143236 88740147
Heart rate increased 86.32 10.88 558 744506 112344 89771039
Head injury 85.60 10.88 78 744986 31110 89852273
Sleep apnoea syndrome 85.24 10.88 81 744983 31666 89851717
Blood lactate dehydrogenase increased 85.05 10.88 54 745010 25878 89857505
Blood sodium decreased 84.56 10.88 62 745002 27551 89855832
Clostridium difficile colitis 84.36 10.88 58 745006 26648 89856735
Device related infection 84.16 10.88 54 745010 25732 89857651
Tachypnoea 83.83 10.88 35 745029 21274 89862109
Lip swelling 83.67 10.88 117 744947 38493 89844890
Body height below normal 83.48 10.88 96 744968 2072 89881311
Subarachnoid haemorrhage 83.39 10.88 22 745042 17882 89865501
Leukocytosis 83.29 10.88 79 744985 30911 89852472
Joint injury 83.15 10.88 506 744558 32158 89851225
Coagulopathy 82.77 10.88 44 745020 23245 89860138
Skin haemorrhage 82.70 10.88 36 745028 21344 89862039
Clostridium difficile infection 82.44 10.88 106 744958 36139 89847244
Spinal stenosis 82.09 10.88 322 744742 17102 89866281
Prescribed underdose 82.05 10.88 961 744103 74058 89809325
Anuria 82.02 10.88 12 745052 14806 89868577
Intestinal obstruction 81.99 10.88 111 744953 37020 89846363
Human antichimeric antibody positive 80.71 10.88 86 744978 1700 89881683
General physical health deterioration 80.33 10.88 3629 741435 351486 89531897
Osteoporosis 80.22 10.88 1176 743888 95355 89788028
Therapy cessation 79.99 10.88 109 744955 36252 89847131
Neuroleptic malignant syndrome 79.57 10.88 14 745050 15082 89868301
Blood glucose decreased 79.33 10.88 47 745017 23382 89860001
Device difficult to use 78.88 10.88 23 745041 17502 89865881
Peripheral venous disease 78.47 10.88 1044 744020 82877 89800506
Influenza like illness 78.29 10.88 368 744696 80243 89803140
Skin necrosis 78.14 10.88 311 744753 16630 89866753
Complication associated with device 78.05 10.88 31 745033 19418 89863965
Wound infection 77.99 10.88 1269 743795 105133 89778250
Joint laxity 77.92 10.88 102 744962 2526 89880857
Bursitis 77.62 10.88 1517 743547 130137 89753246
Weight increased 77.49 10.88 4189 740875 413738 89469645
Paranoia 77.44 10.88 8 745056 12900 89870483
Multiple sclerosis 77.16 10.88 69 744995 27771 89855612
Wrist deformity 76.99 10.88 113 744951 3125 89880258
Sneezing 76.98 10.88 79 744985 29790 89853593
Renal disorder 76.90 10.88 120 744944 37739 89845644
Eye swelling 76.56 10.88 77 744987 29309 89854074
Rheumatoid lung 76.44 10.88 128 744936 3975 89879408
Cellulitis 76.32 10.88 439 744625 90898 89792485
Mental disorder 76.14 10.88 92 744972 32226 89851157
Autoimmune disorder 76.07 10.88 965 744099 75779 89807604
Vaginal haemorrhage 75.84 10.88 87 744977 31184 89852199
Adverse reaction 75.46 10.88 460 744604 29252 89854131
Akathisia 75.21 10.88 4 745060 11155 89872228
Onychomycosis 75.20 10.88 546 744518 36830 89846553
Transfusion 75.05 10.88 25 745039 17463 89865920
Mania 74.66 10.88 13 745051 14111 89869272
Haematotoxicity 74.61 10.88 8 745056 12527 89870856
Hypersomnia 74.60 10.88 42 745022 21489 89861894
Nasal congestion 74.58 10.88 392 744672 83022 89800361
Ear pain 74.53 10.88 764 744300 56938 89826445
Blood triglycerides increased 74.21 10.88 12 745052 13749 89869634
Sinus disorder 74.04 10.88 105 744959 34342 89849041
Hypercholesterolaemia 73.84 10.88 1203 743861 99689 89783694
Psychotic disorder 73.47 10.88 89 744975 31141 89852242
Onychomadesis 73.38 10.88 637 744427 45361 89838022
Pulmonary congestion 73.16 10.88 34 745030 19399 89863984
Abdominal distension 73.06 10.88 703 744361 129898 89753485
Nightmare 72.97 10.88 44 745020 21681 89861702
Retching 72.94 10.88 33 745031 19126 89864257
Arthrodesis 72.90 10.88 106 744958 2906 89880477
Hypothermia 72.80 10.88 19 745045 15556 89867827
Lacrimation increased 72.72 10.88 69 744995 26993 89856390
Chest pain 72.54 10.88 2036 743028 317609 89565774
Rheumatoid factor negative 72.23 10.88 51 745013 560 89882823
Red blood cell sedimentation rate 72.14 10.88 134 744930 4524 89878859
Metastases to lung 71.95 10.88 21 745043 15970 89867413
Skin discolouration 71.87 10.88 161 744903 44154 89839229
Muscle rigidity 71.75 10.88 15 745049 14294 89869089
Anger 71.71 10.88 13 745051 13707 89869676
Aspartate aminotransferase increased 71.64 10.88 523 744541 102414 89780969
Mental impairment 71.58 10.88 24 745040 16696 89866687
Cystitis 71.20 10.88 294 744770 66424 89816959
Shock 70.95 10.88 79 744985 28699 89854684
Aplastic anaemia 70.61 10.88 12 745052 13257 89870126
Sensory loss 70.60 10.88 30 745034 18045 89865338
Malnutrition 70.60 10.88 32 745032 18526 89864857
Pollakiuria 70.54 10.88 101 744963 32904 89850479
Tardive dyskinesia 70.42 10.88 5 745059 10925 89872458
Haemoptysis 70.20 10.88 103 744961 33217 89850166
Wheelchair user 70.14 10.88 180 744884 7605 89875778
Anal incontinence 70.00 10.88 23 745041 16207 89867176
Sinus tachycardia 69.50 10.88 79 744985 28434 89854949
Muscle spasms 69.38 10.88 1559 743505 250324 89633059
Pulmonary hypertension 69.36 10.88 154 744910 42369 89841014
Feeling cold 69.26 10.88 74 744990 27391 89855992
Lung disorder 68.83 10.88 1666 743398 148217 89735166
Alanine aminotransferase increased 68.76 10.88 631 744433 117707 89765676
Live birth 68.61 10.88 971 744093 78136 89805247
Surgical failure 68.58 10.88 60 745004 919 89882464
Skin burning sensation 68.32 10.88 38 745026 19573 89863810
Presyncope 68.30 10.88 97 744967 31708 89851675
Heart rate irregular 67.43 10.88 60 745004 24208 89859175
Rash macular 67.39 10.88 90 744974 30190 89853193
Oral mucosal exfoliation 67.16 10.88 78 744986 1702 89881681
Adjustment disorder 66.45 10.88 3 745061 9639 89873744
Disseminated intravascular coagulation 66.42 10.88 48 745016 21490 89861893
Second primary malignancy 66.14 10.88 5 745059 10373 89873010
Paraesthesia 65.96 10.88 1560 743504 248766 89634617
Abortion spontaneous 65.61 10.88 226 744838 53830 89829553
Rhinitis allergic 65.34 10.88 28 745036 16757 89866626
Feeling hot 65.14 10.88 375 744689 77633 89805750
Throat irritation 65.10 10.88 195 744869 48500 89834883
Ejection fraction decreased 64.80 10.88 72 744992 26181 89857202
Adjustment disorder with depressed mood 64.74 10.88 733 744331 56020 89827363
Nasal polyps 64.62 10.88 7 745057 10873 89872510
Anti-cyclic citrullinated peptide antibody 64.49 10.88 414 744650 26807 89856576
Panic attack 64.32 10.88 73 744991 26292 89857091
Respiratory disorder 64.23 10.88 815 744249 64001 89819382
Faecaloma 63.80 10.88 6 745058 10425 89872958
Amenorrhoea 63.72 10.88 10 745054 11712 89871671
Seronegative arthritis 63.71 10.88 308 744756 17926 89865457
Nervousness 63.57 10.88 114 744950 33942 89849441
Mydriasis 63.48 10.88 22 745042 14990 89868393
Affect lability 62.92 10.88 35 745029 18028 89865355
Hypoacusis 62.77 10.88 82 744982 27768 89855615
Myelodysplastic syndrome 62.64 10.88 48 745016 20855 89862528
Blood creatine phosphokinase increased 62.51 10.88 115 744949 33908 89849475
Dystonia 62.44 10.88 30 745034 16789 89866594
Drug eruption 62.15 10.88 501 744563 34906 89848477
Cyanosis 61.79 10.88 42 745022 19413 89863970
Mood altered 61.51 10.88 32 745032 17112 89866271
Hypernatraemia 61.34 10.88 4 745060 9383 89874000
Shock haemorrhagic 61.06 10.88 13 745051 12232 89871151
Jaundice cholestatic 60.84 10.88 6 745058 10037 89873346
Loose body in joint 60.70 10.88 66 744998 1336 89882047
Troponin increased 60.57 10.88 17 745047 13264 89870119
Glycosylated haemoglobin increased 60.51 10.88 26 745038 15536 89867847
Liver disorder 60.30 10.88 1363 743701 119906 89763477
Diplopia 60.26 10.88 89 744975 28625 89854758
Neurologic neglect syndrome 60.17 10.88 3 745061 8844 89874539
Radiculopathy 60.05 10.88 39 745025 18466 89864917
Poisoning 59.85 10.88 25 745039 15192 89868191
Incontinence 59.80 10.88 18 745046 13417 89869966
Bacteraemia 59.75 10.88 57 745007 22243 89861140
Drug resistance 59.50 10.88 99 744965 30350 89853033
Pancreatitis acute 59.50 10.88 108 744956 32007 89851376
Enterocolitis 59.22 10.88 8 745056 10482 89872901
Hip fracture 58.84 10.88 114 744950 32963 89850420
Cytomegalovirus infection 58.26 10.88 80 744984 26522 89856861
Hospice care 58.26 10.88 6 745058 9698 89873685
Eye pain 58.23 10.88 178 744886 43990 89839393
Haemorrhage intracranial 57.90 10.88 26 745038 15136 89868247
Ileus 57.73 10.88 32 745032 16514 89866869
Gastrointestinal pain 57.66 10.88 213 744851 10993 89872390
Infective pulmonary exacerbation of cystic fibrosis 57.65 10.88 8 745056 10271 89873112
Lupus-like syndrome 57.59 10.88 635 744429 48211 89835172
Eosinophilia 57.42 10.88 91 744973 28442 89854941
Herpes zoster 57.29 10.88 1095 743969 93549 89789834
Labelled drug-drug interaction medication error 57.28 10.88 24 745040 14558 89868825
Loss of consciousness 57.05 10.88 810 744254 139428 89743955
Ulcer 57.03 10.88 464 744600 32418 89850965
Device breakage 56.99 10.88 22 745042 14022 89869361
International normalised ratio fluctuation 56.97 10.88 96 744968 2997 89880386
Epicondylitis 56.65 10.88 87 744977 2507 89880876
Spinal column injury 56.54 10.88 79 744985 2086 89881297
Back injury 56.31 10.88 609 744455 46013 89837370
Injection site mass 56.28 10.88 59 745005 22031 89861352
Oropharyngeal pain 56.28 10.88 640 744424 114547 89768836
Hyperbilirubinaemia 56.27 10.88 22 745042 13914 89869469
Ageusia 56.22 10.88 31 745033 16045 89867338
Dermatitis atopic 56.17 10.88 66 744998 23406 89859977
Hypoaesthesia oral 56.14 10.88 29 745035 15571 89867812
Brain oedema 55.93 10.88 37 745027 17348 89866035
Nail disorder 55.71 10.88 736 744328 58331 89825052
Pancreatitis 55.48 10.88 341 744723 69485 89813898
Hepatitis 55.35 10.88 853 744211 69886 89813497
Face oedema 55.34 10.88 66 744998 23252 89860131
Tinnitus 55.20 10.88 176 744888 42926 89840457
Graft versus host disease 54.64 10.88 3 745061 8141 89875242
Subdural haematoma 54.13 10.88 35 745029 16610 89866773
Eye disorder 53.89 10.88 398 744666 26992 89856391
Hypoalbuminaemia 53.67 10.88 32 745032 15865 89867518
Polyuria 53.60 10.88 9 745055 10031 89873352
COVID-19 53.58 10.88 1021 744043 167822 89715561
Device malfunction 53.48 10.88 56 745008 20921 89862462
Lymphoedema 53.44 10.88 23 745041 13730 89869653
Infusion site pain 53.42 10.88 50 745014 19688 89863695
Thirst 53.35 10.88 34 745030 16261 89867122
Ataxia 53.34 10.88 42 745022 18000 89865383
Investigation abnormal 53.21 10.88 79 744985 2208 89881175
Colitis microscopic 53.20 10.88 207 744857 10952 89872431
Glomerular filtration rate decreased 53.18 10.88 37 745027 16895 89866488
Cardiogenic shock 53.16 10.88 74 744990 24394 89858989
Arterial occlusive disease 53.05 10.88 18 745046 12428 89870955
Hypovolaemia 52.94 10.88 18 745046 12413 89870970
Thrombotic microangiopathy 52.72 10.88 32 745032 15711 89867672
Dialysis 52.61 10.88 14 745050 11315 89872068
Burning sensation 52.46 10.88 306 744758 63146 89820237
Stress cardiomyopathy 52.43 10.88 22 745042 13333 89870050
Drug tolerance 52.43 10.88 288 744776 17628 89865755
Bloody discharge 52.41 10.88 78 744986 2185 89881198
Urine output decreased 52.39 10.88 19 745045 12584 89870799
Complication of device insertion 52.20 10.88 11 745053 10425 89872958
Hypomania 52.14 10.88 6 745058 8891 89874492
Gastrooesophageal reflux disease 52.12 10.88 1008 744056 165329 89718054
Breast cancer metastatic 51.74 10.88 30 745034 15102 89868281
Foot operation 51.37 10.88 177 744887 8824 89874559
Rash papular 51.15 10.88 55 745009 20300 89863083
Multiple fractures 51.10 10.88 184 744880 9378 89874005
Lipase increased 51.09 10.88 14 745050 11097 89872286
Blood magnesium decreased 51.03 10.88 33 745031 15660 89867723
Pemphigoid 50.68 10.88 7 745057 9019 89874364
Toxic encephalopathy 50.65 10.88 6 745058 8693 89874690
Eosinophil count increased 50.64 10.88 22 745042 13059 89870324
Product storage error 50.52 10.88 55 745009 20186 89863197
Seasonal allergy 50.45 10.88 69 744995 22914 89860469
Depression 50.18 10.88 1991 743073 298610 89584773
Glaucoma 50.00 10.88 317 744747 20438 89862945
Injection site swelling 49.77 10.88 288 744776 59551 89823832
Metastases to lymph nodes 49.65 10.88 17 745047 11672 89871711
Neck pain 49.41 10.88 1257 743807 112706 89770677
Nervous system disorder 49.26 10.88 63 745001 21530 89861853
Drug reaction with eosinophilia and systemic symptoms 49.08 10.88 183 744881 42575 89840808
Colitis ischaemic 49.02 10.88 20 745044 12326 89871057
Product preparation error 48.96 10.88 12 745052 10249 89873134
C-reactive protein 48.79 10.88 432 744632 30935 89852448
Blood calcium increased 48.75 10.88 19 745045 12039 89871344
Cholecystitis 48.72 10.88 41 745023 16999 89866384
Enthesopathy 48.60 10.88 179 744885 9225 89874158
Blood albumin decreased 48.57 10.88 40 745024 16763 89866620
Pulmonary arterial hypertension 48.57 10.88 88 744976 26099 89857284
Needle issue 48.54 10.88 27 745037 13907 89869476
Illness 48.51 10.88 435 744629 81534 89801849
Red cell distribution width decreased 48.45 10.88 74 744990 2122 89881261
Agranulocytosis 48.36 10.88 138 744926 34864 89848519
Toxic epidermal necrolysis 48.13 10.88 124 744940 32404 89850979
Physical disability 47.82 10.88 103 744961 3878 89879505
Unintended pregnancy 47.77 10.88 4 745060 7633 89875750
Lower limb fracture 47.56 10.88 972 744092 84041 89799342
Sinus congestion 47.50 10.88 96 744968 27328 89856055
Stevens-Johnson syndrome 47.41 10.88 107 744957 29269 89854114
Vascular access complication 47.27 10.88 77 744987 2336 89881047
Upper respiratory tract infection 47.10 10.88 756 744308 127562 89755821
Supraventricular tachycardia 47.08 10.88 39 745025 16297 89867086
Sinus bradycardia 47.00 10.88 42 745022 16910 89866473
Productive cough 46.92 10.88 406 744658 76657 89806726
Proctalgia 46.89 10.88 6 745058 8192 89875191
Salivary hypersecretion 46.70 10.88 9 745055 9083 89874300
Musculoskeletal chest pain 46.61 10.88 77 744987 23673 89859710
Myocardial ischaemia 46.37 10.88 28 745036 13786 89869597
Hallucination, auditory 46.21 10.88 38 745026 15937 89867446
Acquired pigmented retinopathy 46.07 10.88 13 745051 4 89883379
Pericardial effusion 46.06 10.88 152 744912 36681 89846702
Right ventricular failure 45.96 10.88 54 745010 19151 89864232
Ankle arthroplasty 45.81 10.88 83 744981 2748 89880635
Fracture 45.77 10.88 69 744995 22007 89861376
Anaphylactic shock 45.66 10.88 122 744942 31495 89851888
Acute coronary syndrome 45.46 10.88 16 745048 10797 89872586
Sensory disturbance 45.42 10.88 36 745028 15377 89868006
Device leakage 45.18 10.88 13 745051 9978 89873405
Antiphospholipid syndrome 45.14 10.88 73 744991 2201 89881182
Retinitis 44.90 10.88 499 744565 37959 89845424
Cholecystitis acute 44.87 10.88 11 745053 9393 89873990
Vascular device infection 44.86 10.88 21 745043 11931 89871452
Hepatic encephalopathy 44.73 10.88 29 745035 13743 89869640
Bronchospasm 44.63 10.88 63 745001 20646 89862737
Hiatus hernia 44.60 10.88 88 744976 25273 89858110
Aspiration 44.57 10.88 38 745026 15655 89867728
Interstitial lung disease 44.55 10.88 879 744185 75526 89807857
Acute pulmonary oedema 44.18 10.88 12 745052 9568 89873815
Transplant rejection 44.04 10.88 25 745039 12733 89870650
Haematuria 43.81 10.88 144 744920 34793 89848590
Heavy menstrual bleeding 43.70 10.88 63 745001 20467 89862916
Asphyxia 43.67 10.88 4 745060 7099 89876284
Petechiae 43.64 10.88 39 745025 15702 89867681
Intermenstrual bleeding 43.59 10.88 11 745053 9212 89874171
Abnormal dreams 43.47 10.88 19 745045 11238 89872145
Body temperature increased 43.37 10.88 560 744504 44150 89839233
Pneumonia viral 43.15 10.88 165 744899 8658 89874725
Viral upper respiratory tract infection 42.67 10.88 162 744902 8472 89874911
Post transplant lymphoproliferative disorder 42.49 10.88 4 745060 6945 89876438
Acidosis 42.49 10.88 26 745038 12710 89870673
Nasal oedema 42.45 10.88 3 745061 6581 89876802
Suspected suicide 42.26 10.88 13 745051 9555 89873828
Rhinorrhoea 42.24 10.88 493 744571 87823 89795560
Central nervous system lupus 42.13 10.88 54 745010 1309 89882074
Urticaria 42.06 10.88 3049 742015 309685 89573698
Mycotic allergy 42.03 10.88 48 745016 1028 89882355
Gangrene 41.97 10.88 27 745037 12849 89870534
Faeces discoloured 41.96 10.88 69 744995 21251 89862132
Haemorrhagic stroke 41.77 10.88 3 745061 6493 89876890
Road traffic accident 41.75 10.88 1170 743894 106456 89776927
Basal cell carcinoma 41.65 10.88 439 744625 32950 89850433
Anhedonia 41.51 10.88 21 745043 11410 89871973
Exposure via skin contact 41.44 10.88 18 745046 10687 89872696
Antibody test positive 41.39 10.88 82 744982 2907 89880476
Eyelid oedema 40.68 10.88 22 745042 11512 89871871
Haemodynamic instability 40.53 10.88 23 745041 11716 89871667
Visual acuity reduced 40.51 10.88 82 744982 23328 89860055
Butterfly rash 40.49 10.88 68 744996 2117 89881266
Hyperreflexia 40.27 10.88 4 745060 6653 89876730
Frequent bowel movements 40.22 10.88 288 744776 56647 89826736
Throat tightness 40.18 10.88 117 744947 29367 89854016
Anticipatory anxiety 39.93 10.88 50 745014 1183 89882200
Complication of device removal 39.90 10.88 3 745061 6252 89877131
Drug level decreased 39.89 10.88 15 745049 9715 89873668
Failure to thrive 39.81 10.88 10 745054 8401 89874982
Mouth ulceration 39.76 10.88 503 744561 39471 89843912
Mean platelet volume decreased 39.74 10.88 80 744984 2870 89880513
Oliguria 39.36 10.88 19 745045 10605 89872778
Haemorrhoids 39.35 10.88 102 744962 26600 89856783
Staphylococcal infection 39.30 10.88 235 744829 48204 89835179
Eating disorder 39.29 10.88 110 744954 27963 89855420
Ocular hyperaemia 39.22 10.88 144 744920 33654 89849729
Extra dose administered 39.19 10.88 13 745051 9105 89874278
Hydronephrosis 39.09 10.88 27 745037 12375 89871008
Pain in extremity 39.04 10.88 4253 740811 446276 89437107
Anosmia 39.02 10.88 16 745048 9832 89873551
Metastasis 38.99 10.88 3 745061 6134 89877249
Hyperammonaemia 38.88 10.88 4 745060 6471 89876912
Cholecystitis chronic 38.88 10.88 16 745048 9810 89873573
Muscle tightness 38.84 10.88 32 745032 13407 89869976
Mesenteritis 38.80 10.88 28 745036 319 89883064
Blindness 38.76 10.88 102 744962 26466 89856917
Bradykinesia 38.74 10.88 5 745059 6783 89876600
Phospholipidosis 38.71 10.88 25 745039 234 89883149
Ocular toxicity 38.65 10.88 46 745018 1031 89882352
Exposure to toxic agent 38.64 10.88 9 745055 7958 89875425
Bone swelling 38.63 10.88 59 745005 1692 89881691
Prothrombin time prolonged 38.52 10.88 16 745048 9756 89873627
Eyelid ptosis 38.43 10.88 13 745051 8993 89874390
Sudden death 38.20 10.88 21 745043 10888 89872495
Dissociation 38.20 10.88 5 745059 6710 89876673
Personality change 38.13 10.88 7 745057 7314 89876069
Foetal death 38.11 10.88 70 744994 20653 89862730
Neuralgia 38.02 10.88 132 744932 31368 89852015
Muscle spasticity 37.96 10.88 451 744613 34871 89848512
Sickle cell anaemia with crisis 37.95 10.88 7 745057 7290 89876093
Venoocclusive liver disease 37.87 10.88 3 745061 5990 89877393
Uterine perforation 37.71 10.88 8 745056 7546 89875837
Psychomotor hyperactivity 37.66 10.88 30 745034 12783 89870600
Activated partial thromboplastin time prolonged 37.63 10.88 9 745055 7816 89875567
Apathy 37.59 10.88 22 745042 11018 89872365
Exostosis 37.55 10.88 630 744434 52504 89830879
Delusion 37.52 10.88 35 745029 13805 89869578
Headache 37.52 10.88 6379 738685 856367 89027016
Myocarditis 37.33 10.88 35 745029 13771 89869612
Klebsiella infection 37.27 10.88 19 745045 10278 89873105
Product label confusion 37.26 10.88 318 744746 22532 89860851
Renal function test abnormal 37.18 10.88 7 745057 7184 89876199
Cholangitis 37.12 10.88 7 745057 7175 89876208
Toxic skin eruption 37.06 10.88 45 745019 15729 89867654
Nephropathy toxic 36.93 10.88 30 745034 12658 89870725
Renal injury 36.92 10.88 19 745045 10224 89873159
Chromaturia 36.92 10.88 63 745001 19124 89864259
Drug dose omission by device 36.85 10.88 19 745045 10212 89873171
Product substitution issue 36.65 10.88 57 745007 17951 89865432
Synovial cyst 36.48 10.88 192 744872 11560 89871823
Fungal infection 36.19 10.88 204 744860 42457 89840926
Lupus vasculitis 36.19 10.88 34 745030 574 89882809
Skin irritation 36.18 10.88 35 745029 13568 89869815
Neutrophil count increased 36.10 10.88 65 744999 19325 89864058
Septic shock 36.05 10.88 481 744583 83679 89799704
Micturition urgency 36.01 10.88 24 745040 11209 89872174
Hyperventilation 35.99 10.88 6 745058 6722 89876661
Lower gastrointestinal haemorrhage 35.97 10.88 14 745050 8878 89874505
Hyperuricaemia 35.92 10.88 6 745058 6713 89876670
Central nervous system lesion 35.85 10.88 26 745038 11620 89871763
Dermatomyositis 35.78 10.88 83 744981 3287 89880096
Ovarian neoplasm 35.68 10.88 41 745023 884 89882499
Stress 35.67 10.88 463 744601 80932 89802451
Major depression 35.60 10.88 19 745045 10016 89873367
Fear 35.39 10.88 51 745013 16571 89866812
Device use error 35.33 10.88 8 745056 7213 89876170
Device occlusion 35.32 10.88 16 745048 9266 89874117
Injection site haemorrhage 35.32 10.88 117 744947 28201 89855182
Metabolic disorder 35.13 10.88 9 745055 7461 89875922
Heart rate abnormal 35.06 10.88 4 745060 5967 89877416
Arteriosclerosis 35.05 10.88 23 745041 10830 89872553
Haemodialysis 35.00 10.88 14 745050 8733 89874650
Laryngeal disorder 34.88 10.88 45 745019 1098 89882285
Pelvic pain 34.83 10.88 45 745019 15312 89868071
Lupus vulgaris 34.73 10.88 542 744522 44517 89838866
Blood thyroid stimulating hormone increased 34.49 10.88 16 745048 9139 89874244
Pustular psoriasis 34.46 10.88 266 744798 18290 89865093
Large intestine polyp 34.45 10.88 17 745047 9369 89874014
Hallucinations, mixed 34.44 10.88 4 745060 5885 89877498
Cold sweat 34.33 10.88 39 745025 14042 89869341
Fear of injection 34.32 10.88 150 744914 8365 89875018
Serositis 34.31 10.88 48 745016 1269 89882114
Red blood cell vacuolisation 34.28 10.88 9 745055 0 89883383
Skin toxicity 34.21 10.88 7 745057 6772 89876611
Blood test abnormal 34.07 10.88 76 744988 20876 89862507
Eructation 33.89 10.88 24 745040 10858 89872525
Oral candidiasis 33.75 10.88 163 744901 35292 89848091
Infusion site reaction 33.74 10.88 270 744794 18769 89864614
Post procedural haemorrhage 33.73 10.88 15 745049 8783 89874600
Respiratory tract congestion 33.67 10.88 114 744950 27296 89856087
Faeces soft 33.55 10.88 10 745054 7501 89875882
Tension headache 33.53 10.88 10 745054 7499 89875884
Presbyacusis 33.49 10.88 76 744988 2966 89880417
Pneumonitis 33.40 10.88 219 744845 43951 89839432
Lung neoplasm malignant 33.31 10.88 96 744968 24177 89859206
Polyneuropathy 33.25 10.88 68 744996 19273 89864110
Hyperthermia 33.24 10.88 22 745042 10313 89873070
Pulseless electrical activity 33.05 10.88 16 745048 8916 89874467
Restless legs syndrome 32.98 10.88 86 744978 22384 89860999
Restrictive cardiomyopathy 32.90 10.88 25 745039 310 89883073
Wrong product administered 32.82 10.88 11 745053 7654 89875729
Retinal degeneration 32.81 10.88 43 745021 1066 89882317
Renal tubular necrosis 32.65 10.88 43 745021 14512 89868871
Respiratory tract infection 32.61 10.88 319 744745 58759 89824624
Hepatotoxicity 32.56 10.88 544 744520 45298 89838085
Initial insomnia 32.49 10.88 18 745046 9292 89874091
Eye irritation 32.47 10.88 156 744908 33822 89849561
Left ventricular dysfunction 32.24 10.88 44 745020 14625 89868758
Ketoacidosis 32.23 10.88 4 745060 5591 89877792
Therapy change 32.21 10.88 14 745050 8308 89875075
Caesarean section 32.20 10.88 65 744999 18512 89864871
Cardiomegaly 32.14 10.88 67 744997 18858 89864525
Mood swings 32.13 10.88 77 744987 20625 89862758
Hypotonia 32.05 10.88 28 745036 11398 89871985
Multiple-drug resistance 31.86 10.88 12 745052 7764 89875619
Application site erythema 31.84 10.88 3 745061 5205 89878178
Spinal fracture 31.76 10.88 85 744979 21931 89861452
Dermatitis contact 31.71 10.88 39 745025 13556 89869827
Anovulatory cycle 31.67 10.88 19 745045 154 89883229
Unevaluable event 31.62 10.88 293 744771 54555 89828828
Bone density abnormal 31.55 10.88 90 744974 4050 89879333
Ear infection 31.54 10.88 774 744290 69001 89814382
Respiration abnormal 31.45 10.88 13 745051 7950 89875433
Tricuspid valve incompetence 31.23 10.88 56 745008 16675 89866708
Pleural fibrosis 31.22 10.88 82 744982 3514 89879869
Duodenal ulcer 31.18 10.88 20 745044 9532 89873851
Infusion site erythema 31.07 10.88 40 745024 13630 89869753
Therapeutic response shortened 31.03 10.88 91 744973 22788 89860595
Joint arthroplasty 30.92 10.88 80 744984 3397 89879986
Ileus paralytic 30.90 10.88 3 745061 5082 89878301
Blood glucose fluctuation 30.89 10.88 3 745061 5080 89878303
Walking aid user 30.85 10.88 436 744628 35070 89848313
Bradyphrenia 30.76 10.88 12 745052 7600 89875783
Cutaneous vasculitis 30.76 10.88 129 744935 7064 89876319
Pregnancy with contraceptive device 30.76 10.88 3 745061 5063 89878320
Peripheral sensory neuropathy 30.70 10.88 19 745045 9231 89874152
Post-traumatic stress disorder 30.66 10.88 9 745055 6819 89876564
Exposure during pregnancy 30.62 10.88 2316 742748 236094 89647289
Mean cell volume decreased 30.58 10.88 94 744970 4412 89878971
Extremity contracture 30.57 10.88 45 745019 1248 89882135
Viral infection 30.48 10.88 207 744857 41207 89842176
Subacute cutaneous lupus erythematosus 30.41 10.88 81 744983 3501 89879882
Polycystic ovaries 30.34 10.88 5 745059 5649 89877734
Myopathy toxic 30.32 10.88 31 745033 583 89882800
Somnambulism 30.27 10.88 7 745057 6221 89877162
Hypertensive crisis 30.17 10.88 63 745001 17721 89865662
Coma scale abnormal 30.13 10.88 5 745059 5621 89877762
Partial seizures 30.08 10.88 11 745053 7249 89876134
Hypocalcaemia 30.08 10.88 214 744850 42154 89841229
Hair follicle tumour benign 30.05 10.88 26 745038 392 89882991
White blood cell count abnormal 30.05 10.88 12 745052 7492 89875891
Product administration interrupted 30.03 10.88 35 745029 12457 89870926
Uterine leiomyoma 30.02 10.88 27 745037 10837 89872546
Electrocardiogram U-wave abnormality 30.00 10.88 11 745053 22 89883361
Lyme disease 29.94 10.88 90 744974 4172 89879211
Blood uric acid increased 29.75 10.88 13 745051 7691 89875692
White blood cell count increased 29.64 10.88 382 744682 66859 89816524
Soft tissue disorder 29.58 10.88 90 744974 4200 89879183
Middle insomnia 29.56 10.88 58 745006 16693 89866690
Device deployment issue 29.56 10.88 3 745061 4906 89878477
Premature labour 29.52 10.88 40 745024 13336 89870047
Blood loss anaemia 29.48 10.88 24 745040 10116 89873267
Cytopenia 29.45 10.88 62 745002 17387 89865996
Infiltration anaesthesia 29.40 10.88 19 745045 178 89883205
Mixed connective tissue disease 29.30 10.88 30 745034 565 89882818
Thyroid neoplasm 29.29 10.88 86 744978 3935 89879448
Neck mass 29.21 10.88 84 744980 3798 89879585
Thinking abnormal 29.15 10.88 32 745032 11700 89871683
Cutaneous lupus erythematosus 29.03 10.88 73 744991 3045 89880338
Atrioventricular block first degree 28.92 10.88 17 745047 8494 89874889
Gallbladder disorder 28.91 10.88 76 744988 19727 89863656
Product adhesion issue 28.84 10.88 4 745060 5138 89878245
Arteriosclerosis coronary artery 28.84 10.88 22 745042 9581 89873802
Transaminases abnormal 28.78 10.88 33 745031 710 89882673
Sexual dysfunction 28.76 10.88 3 745061 4801 89878582
Generalised oedema 28.68 10.88 72 744992 18981 89864402
Gastric ulcer 28.63 10.88 122 744942 27326 89856057
Atrial tachycardia 28.59 10.88 7 745057 5983 89877400
Surgery 28.44 10.88 234 744830 44653 89838730
Blood pressure inadequately controlled 28.32 10.88 8 745056 6216 89877167
Neuropsychiatric lupus 28.21 10.88 19 745045 192 89883191
Pleural thickening 28.13 10.88 74 744990 3174 89880209
Application site pain 28.13 10.88 3 745061 4717 89878666
Histoplasmosis disseminated 28.10 10.88 60 745004 2245 89881138
Drug specific antibody 27.92 10.88 63 745001 2449 89880934
Pathogen resistance 27.87 10.88 16 745048 8099 89875284
Hypercapnia 27.87 10.88 10 745054 6667 89876716
Blood lactic acid increased 27.81 10.88 19 745045 8759 89874624
Lung infiltration 27.77 10.88 52 745012 15230 89868153
Diarrhoea haemorrhagic 27.71 10.88 28 745036 10635 89872748
Lymphadenopathy 27.49 10.88 242 744822 45533 89837850
Gingivitis 27.46 10.88 22 745042 9347 89874036
Joint dislocation 27.38 10.88 517 744547 44065 89839318
Injection site reaction 27.28 10.88 969 744095 91111 89792272
Amylase increased 27.21 10.88 12 745052 7060 89876323
Blood potassium increased 27.08 10.88 84 744980 20665 89862718
Urosepsis 26.98 10.88 87 744977 21145 89862238
Mass excision 26.95 10.88 23 745041 340 89883043
Brain injury 26.94 10.88 15 745049 7723 89875660
Osteoporotic fracture 26.91 10.88 93 744971 4643 89878740
Rales 26.91 10.88 56 745008 15771 89867612
Oesophagitis 26.89 10.88 64 745000 17185 89866198
Neck deformity 26.71 10.88 57 745007 2132 89881251
Hypertonia 26.69 10.88 5 745059 5150 89878233
Crohn's disease 26.68 10.88 4 745060 4847 89878536
Gingival pain 26.65 10.88 24 745040 9628 89873755
Aortic arteriosclerosis 26.61 10.88 15 745049 7669 89875714
Facial pain 26.56 10.88 42 745022 13140 89870243
Femoral neck fracture 26.44 10.88 27 745037 10206 89873177
Emotional disorder 26.40 10.88 52 745012 14945 89868438
Facial paralysis 26.38 10.88 55 745009 15479 89867904
Maternal exposure timing unspecified 26.37 10.88 292 744772 22191 89861192
Vasculitic rash 26.28 10.88 44 745020 1366 89882017
Product physical issue 26.27 10.88 7 745057 5653 89877730
Sleep terror 26.19 10.88 3 745061 4461 89878922
Prescribed overdose 26.18 10.88 1016 744048 96609 89786774
Atrial flutter 26.01 10.88 30 745034 10728 89872655
Cystoid macular oedema 25.99 10.88 55 745009 2045 89881338
Colon cancer 25.94 10.88 31 745033 10913 89872470
Blood immunoglobulin E increased 25.89 10.88 3 745061 4422 89878961
Affective disorder 25.87 10.88 16 745048 7777 89875606
Large intestine perforation 25.82 10.88 25 745039 9687 89873696
Injection site bruising 25.79 10.88 290 744774 52017 89831366
Sensation of foreign body 25.79 10.88 10 745054 6356 89877027
No adverse event 25.79 10.88 398 744666 67584 89815799
Rhinitis 25.72 10.88 45 745019 13527 89869856
Dizziness postural 25.62 10.88 22 745042 9031 89874352
Incoherent 25.41 10.88 5 745059 4972 89878411
Hepatic enzyme abnormal 25.21 10.88 127 744937 7515 89875868
Paradoxical drug reaction 25.17 10.88 8 745056 5758 89877625
Body tinea 25.15 10.88 55 745009 2093 89881290
Metabolic encephalopathy 25.13 10.88 12 745052 6740 89876643
Ventricular tachycardia 25.06 10.88 111 744953 24597 89858786
Transaminases increased 24.90 10.88 191 744873 37001 89846382
Product residue present 24.88 10.88 3 745061 4288 89879095
Lupus myocarditis 24.70 10.88 12 745052 60 89883323
Choking 24.57 10.88 38 745026 11995 89871388
Embedded device 24.56 10.88 3 745061 4245 89879138
Device failure 24.56 10.88 13 745051 6884 89876499
Atrial septal defect 24.55 10.88 19 745045 8215 89875168
Cutaneous coccidioidomycosis 24.54 10.88 9 745055 18 89883365
Muscular weakness 24.51 10.88 1419 743645 205247 89678136
Paronychia 24.48 10.88 18 745046 7988 89875395
Exercise tolerance decreased 24.39 10.88 16 745048 7535 89875848
Head discomfort 24.37 10.88 62 745002 16271 89867112
Hypovolaemic shock 24.35 10.88 14 745050 7080 89876303
Treatment noncompliance 24.25 10.88 290 744774 51437 89831946
Mitral valve incompetence 24.19 10.88 99 744965 22425 89860958
Pancreatic carcinoma 24.14 10.88 20 745044 8357 89875026
Carotid artery occlusion 24.02 10.88 11 745053 6331 89877052
Diffuse alopecia 23.99 10.88 39 745025 1181 89882202
Shrinking lung syndrome 23.98 10.88 16 745048 159 89883224
Wrist surgery 23.96 10.88 34 745030 911 89882472
Blood urine present 23.96 10.88 68 744996 17210 89866173
Sensitivity to weather change 23.91 10.88 140 744924 8774 89874609
Injection site nodule 23.90 10.88 4 745060 4469 89878914
Nocardiosis 23.75 10.88 60 745004 2510 89880873
Drug level above therapeutic 23.74 10.88 9 745055 5800 89877583
Impetigo herpetiformis 23.71 10.88 15 745049 135 89883248
Hypopnoea 23.59 10.88 4 745060 4427 89878956
Cardiovascular disorder 23.57 10.88 47 745017 13445 89869938
Blood creatine increased 23.55 10.88 14 745050 6953 89876430
Coronary artery stenosis 23.54 10.88 7 745057 5259 89878124
Electrocardiogram abnormal 23.54 10.88 30 745034 10268 89873115
Menstruation irregular 23.53 10.88 19 745045 8041 89875342
Brain natriuretic peptide increased 23.40 10.88 10 745054 5995 89877388
Atelectasis 23.36 10.88 112 744952 24297 89859086
Injection site pruritus 23.30 10.88 307 744757 53527 89829856
Internal haemorrhage 23.23 10.88 11 745053 6209 89877174
Non-small cell lung cancer 23.23 10.88 4 745060 4377 89879006
Central nervous system lymphoma 23.19 10.88 52 745012 2013 89881370
Granulocytopenia 23.14 10.88 12 745052 6429 89876954
Cytomegalovirus mucocutaneous ulcer 23.13 10.88 11 745053 52 89883331
Cartilage atrophy 23.10 10.88 16 745048 170 89883213
Bruxism 23.10 10.88 4 745060 4359 89879024
Fibrin D dimer increased 23.09 10.88 8 745056 5452 89877931
Gastrointestinal toxicity 23.05 10.88 145 744919 9322 89874061
Cardiomyopathy 23.05 10.88 261 744803 19945 89863438
Vitamin D deficiency 22.96 10.88 71 744993 17485 89865898
Insurance issue 22.96 10.88 34 745030 10924 89872459
Clostridial infection 22.96 10.88 5 745059 4631 89878752
Anterior chamber cleavage syndrome 22.86 10.88 16 745048 173 89883210
Brain death 22.86 10.88 3 745061 4018 89879365
Loss of employment 22.83 10.88 65 744999 2922 89880461
Pneumonia bacterial 22.82 10.88 44 745020 12746 89870637
Hepatitis cholestatic 22.80 10.88 22 745042 8539 89874844
Pre-existing condition improved 22.79 10.88 25 745039 9144 89874239
Hereditary angioedema 22.77 10.88 26 745038 9339 89874044
Syringe issue 22.72 10.88 3 745061 3999 89879384
Hepatic cirrhosis 22.70 10.88 681 744383 62572 89820811
Neuromyopathy 22.67 10.88 30 745034 751 89882632
Aplasia 22.64 10.88 3 745061 3988 89879395
Bronchitis chronic 22.62 10.88 88 744976 4655 89878728
Brain neoplasm 22.61 10.88 6 745058 4858 89878525
Pain of skin 22.52 10.88 63 745001 16019 89867364
Pseudomonas infection 22.51 10.88 56 745008 14809 89868574
Red blood cell count decreased 22.45 10.88 258 744806 46093 89837290
Low density lipoprotein increased 22.45 10.88 20 745044 8065 89875318
Therapeutic response unexpected 22.37 10.88 98 744966 21782 89861601
Drooling 22.32 10.88 5 745059 4541 89878842
Increased appetite 22.30 10.88 39 745025 11726 89871657
Tuberculosis 22.26 10.88 178 744886 12371 89871012
Eye discharge 22.25 10.88 21 745043 8237 89875146
Application site pruritus 22.25 10.88 4 745060 4243 89879140
Cerebral ischaemia 22.24 10.88 16 745048 7180 89876203
Bacterial infection 22.19 10.88 108 744956 23336 89860047
Rib fracture 22.11 10.88 127 744937 26308 89857075
Heparin-induced thrombocytopenia 22.09 10.88 8 745056 5304 89878079
Gastric ulcer haemorrhage 22.09 10.88 8 745056 5303 89878080
Fistula 22.09 10.88 41 745023 12048 89871335
White blood cells urine positive 22.05 10.88 13 745051 6485 89876898
Mean cell haemoglobin decreased 21.96 10.88 99 744965 5596 89877787
Expired product administered 21.91 10.88 15 745049 6907 89876476
Retinal haemorrhage 21.83 10.88 10 745054 5754 89877629
Pharyngitis 21.75 10.88 276 744788 21671 89861712
Hepatic necrosis 21.68 10.88 13 745051 6425 89876958
Metastases to peritoneum 21.58 10.88 4 745060 4151 89879232
Fluid intake reduced 21.56 10.88 4 745060 4148 89879235
Parosmia 21.48 10.88 16 745048 7053 89876330
Mean cell haemoglobin concentration decreased 21.48 10.88 5 745059 4423 89878960
Laboratory test abnormal 21.45 10.88 230 744834 41624 89841759
Hyperlactacidaemia 21.44 10.88 4 745060 4132 89879251
Petit mal epilepsy 21.43 10.88 7 745057 4951 89878432
Nail operation 21.41 10.88 48 745016 1858 89881525
Haematocrit decreased 21.39 10.88 230 744834 41602 89841781
Neutrophil count abnormal 21.38 10.88 4 745060 4124 89879259
Peripheral coldness 21.30 10.88 52 745012 13840 89869543
Hepatic lesion 21.24 10.88 10 745054 5663 89877720
Intestinal ischaemia 21.23 10.88 25 745039 8858 89874525
Peritonitis bacterial 21.15 10.88 8 745056 5163 89878220
Nystagmus 21.14 10.88 17 745047 7210 89876173
Immune thrombocytopenia 21.13 10.88 49 745015 13277 89870106
Catheter site infection 21.12 10.88 10 745054 5644 89877739
Breast cancer female 21.07 10.88 58 745006 14828 89868555
COVID-19 treatment 21.02 10.88 13 745051 112 89883271
Skin ulcer 21.02 10.88 550 744514 49525 89833858
Cardiac murmur 20.79 10.88 78 744986 18116 89865267
Ventricular extrasystoles 20.79 10.88 49 745015 13201 89870182
Staphylococcal sepsis 20.77 10.88 28 745036 9355 89874028
Metastases to meninges 20.73 10.88 3 745061 3732 89879651
Infusion site extravasation 20.72 10.88 33 745031 10295 89873088
Bipolar disorder 20.72 10.88 26 745038 8959 89874424
Blood phosphorus increased 20.70 10.88 5 745059 4313 89879070
Intestinal sepsis 20.70 10.88 19 745045 311 89883072
Vitamin D decreased 20.69 10.88 42 745022 11937 89871446
Diaphragm muscle weakness 20.69 10.88 9 745055 33 89883350
Enteritis 20.69 10.88 33 745031 10288 89873095
Tooth loss 20.60 10.88 19 745045 7535 89875848
Ankle operation 20.55 10.88 41 745023 1461 89881922
Gastrointestinal inflammation 20.55 10.88 15 745049 6681 89876702
Psychiatric symptom 20.51 10.88 17 745047 7101 89876282
Cornea verticillata 20.50 10.88 17 745047 241 89883142
Cerebral haematoma 20.49 10.88 5 745059 4284 89879099
Diverticulum 20.47 10.88 43 745021 12070 89871313
Cardiac failure acute 20.46 10.88 42 745022 11887 89871496
Vitamin B12 decreased 20.44 10.88 9 745055 5301 89878082
Bacterial test positive 20.38 10.88 10 745054 5529 89877854
Ischaemia 20.35 10.88 9 745055 5286 89878097
Respiratory rate decreased 20.34 10.88 4 745060 3979 89879404
Infusion site swelling 20.32 10.88 41 745023 11679 89871704
Laryngitis 20.31 10.88 554 744510 50199 89833184
Penicillium infection 20.30 10.88 18 745046 281 89883102
Escherichia infection 20.29 10.88 65 744999 15830 89867553
Neoplasm 20.28 10.88 26 745038 8877 89874506
Hypophagia 20.27 10.88 193 744871 35744 89847639
Breast pain 20.24 10.88 34 745030 10384 89872999
Pathological fracture 20.21 10.88 30 745034 9630 89873753
Blepharospasm 20.19 10.88 598 744466 54847 89828536
Obsessive-compulsive disorder 20.11 10.88 6 745058 4498 89878885
Temperature intolerance 20.09 10.88 43 745021 11987 89871396
BK virus infection 20.07 10.88 6 745058 4492 89878891
Lupus enteritis 20.02 10.88 11 745053 74 89883309
Nerve injury 19.99 10.88 38 745026 11068 89872315
Bronchopleural fistula 19.99 10.88 17 745047 250 89883133
Thoracic vertebral fracture 19.96 10.88 10 745054 5464 89877919
Malaise 19.96 10.88 4387 740677 581599 89301784
Polyp 19.95 10.88 20 745044 7624 89875759
Palindromic rheumatism 19.94 10.88 15 745049 183 89883200
Concussion 19.92 10.88 38 745026 11053 89872330
Spondylitis 19.89 10.88 191 744873 13987 89869396
Urine analysis abnormal 19.86 10.88 9 745055 5212 89878171
Cushingoid 19.85 10.88 150 744914 10245 89873138
Fundoscopy abnormal 19.77 10.88 7 745057 12 89883371
Atrioventricular block second degree 19.75 10.88 6 745058 4446 89878937
Vulvovaginal candidiasis 19.74 10.88 4 745060 3896 89879487
Hyperprolactinaemia 19.70 10.88 10 745054 5423 89877960
Tender joint count 19.70 10.88 39 745025 1382 89882001
Gastritis erosive 19.62 10.88 16 745048 6739 89876644
Skin fissures 19.61 10.88 96 744968 20713 89862670
Blood chloride decreased 19.59 10.88 14 745050 6305 89877078
Endophthalmitis 19.58 10.88 7 745057 4678 89878705
Cerebral atrophy 19.58 10.88 11 745053 5635 89877748
Type I hypersensitivity 19.55 10.88 5 745059 4150 89879233
Dysmenorrhoea 19.49 10.88 7 745057 4665 89878718
Coronary artery occlusion 19.47 10.88 25 745039 8529 89874854
Bowel movement irregularity 19.46 10.88 15 745049 6499 89876884
Nephrolithiasis 19.43 10.88 285 744779 48800 89834583
Concomitant disease aggravated 19.37 10.88 41 745023 11477 89871906
Foetal exposure during pregnancy 19.36 10.88 243 744821 42732 89840651
Asthma-chronic obstructive pulmonary disease overlap syndrome 19.35 10.88 8 745056 4891 89878492
Pulse absent 19.33 10.88 13 745051 6042 89877341
Synovial fluid analysis 19.32 10.88 59 745005 2759 89880624
Disease susceptibility 19.29 10.88 17 745047 263 89883120
Drug level below therapeutic 19.21 10.88 12 745052 5802 89877581
Adenovirus infection 19.16 10.88 7 745057 4615 89878768
Mycobacterium tuberculosis complex test positive 19.15 10.88 56 745008 2556 89880827
Decubitus ulcer 19.09 10.88 43 745021 11770 89871613
Macular telangiectasia 19.05 10.88 5 745059 0 89883383
Emphysema 19.03 10.88 45 745019 12110 89871273
Staphylococcal bacteraemia 18.97 10.88 20 745044 7449 89875934
Diabetic eye disease 18.94 10.88 14 745050 166 89883217
Cardiac sarcoidosis 18.88 10.88 12 745052 109 89883274
Product dispensing error 18.77 10.88 46 745018 12227 89871156
Refusal of treatment by patient 18.75 10.88 12 745052 5726 89877657
Sluggishness 18.74 10.88 13 745051 5946 89877437
Spinal compression fracture 18.73 10.88 63 745001 15115 89868268
Drug screen positive 18.71 10.88 4 745060 3753 89879630
Hyperlipidaemia 18.68 10.88 111 744953 22805 89860578
Drug-induced liver injury 18.66 10.88 915 744149 89403 89793980
Granulomatous dermatitis 18.66 10.88 15 745049 203 89883180
Formication 18.64 10.88 8 745056 4783 89878600
Performance status decreased 18.57 10.88 6 745058 4274 89879109
Blood magnesium increased 18.57 10.88 66 744998 3342 89880041
Upper-airway cough syndrome 18.55 10.88 63 745001 15072 89868311
Systemic infection 18.53 10.88 8 745056 4767 89878616
Dermatitis acneiform 18.52 10.88 15 745049 6339 89877044
Cytomegalovirus viraemia 18.51 10.88 21 745043 7565 89875818
Pruritus allergic 18.50 10.88 43 745021 1705 89881678
Human herpesvirus 6 infection 18.49 10.88 3 745061 3429 89879954
Breast cancer stage II 18.46 10.88 400 744664 34934 89848449
Bone cyst 18.42 10.88 52 745012 2326 89881057
Blood glucose abnormal 18.42 10.88 31 745033 9461 89873922
Device use issue 18.40 10.88 4 745060 3709 89879674
Heart rate decreased 18.39 10.88 319 744745 53186 89830197
Faecal calprotectin increased 18.38 10.88 5 745059 3982 89879401
Blood pressure abnormal 18.30 10.88 91 744973 19554 89863829
Ear discomfort 18.28 10.88 35 745029 10165 89873218
Urine abnormality 18.25 10.88 22 745042 7715 89875668
Polydipsia 18.24 10.88 6 745058 4225 89879158
Haemorrhage subcutaneous 18.23 10.88 3 745061 3393 89879990
Varicose vein 18.19 10.88 20 745044 7307 89876076
Catheterisation cardiac 18.15 10.88 9 745055 4947 89878436
Haemoglobin abnormal 18.05 10.88 19 745045 7081 89876302
Hypertriglyceridaemia 18.01 10.88 23 745041 7866 89875517
Crying 17.98 10.88 130 744934 25515 89857868
Laryngeal oedema 17.96 10.88 18 745046 6863 89876520
General symptom 17.89 10.88 192 744872 14476 89868907
Body mass index abnormal 17.88 10.88 26 745038 713 89882670
Vertigo positional 17.85 10.88 3 745061 3341 89880042
Micrognathia 17.76 10.88 17 745047 294 89883089
Snoring 17.76 10.88 10 745054 5116 89878267
Colorectal cancer 17.72 10.88 5 745059 3888 89879495
Retinal injury 17.69 10.88 19 745045 379 89883004
Hepatic cancer 17.67 10.88 9 745055 4872 89878511
Pneumonia fungal 17.66 10.88 19 745045 7012 89876371
Mixed liver injury 17.64 10.88 22 745042 7601 89875782
Invasive ductal breast carcinoma 17.64 10.88 23 745041 7795 89875588
Cutaneous tuberculosis 17.63 10.88 14 745050 186 89883197
Truncus arteriosus persistent 17.58 10.88 19 745045 382 89883001
Haemorrhoidal haemorrhage 17.57 10.88 11 745053 5312 89878071
Intestinal perforation 17.55 10.88 57 745007 13824 89869559
Ventricular fibrillation 17.53 10.88 58 745006 13986 89869397
Neoplasm malignant 17.53 10.88 383 744681 33497 89849886
Hypocomplementaemia 17.52 10.88 16 745048 260 89883123
Hypokinesia 17.48 10.88 68 744996 15629 89867754
Pneumocystis jirovecii pneumonia 17.46 10.88 105 744959 21511 89861872
Jugular vein thrombosis 17.46 10.88 4 745060 3577 89879806
Gait disturbance 17.42 10.88 2420 742644 258076 89625307
Ocular discomfort 17.40 10.88 16 745048 6354 89877029
Limb deformity 17.39 10.88 74 744990 4078 89879305
Flank pain 17.36 10.88 90 744974 19132 89864251
Placenta accreta 17.35 10.88 15 745049 226 89883157
Breast cancer recurrent 17.32 10.88 12 745052 5491 89877892
Middle lobe syndrome 17.31 10.88 8 745056 35 89883348
Breast cancer stage I 17.26 10.88 33 745031 9591 89873792
Prescription drug used without a prescription 17.20 10.88 3 745061 3252 89880131
Low birth weight baby 17.18 10.88 135 744929 9332 89874051
Supraventricular extrasystoles 17.17 10.88 11 745053 5246 89878137
Apnoea 17.13 10.88 32 745032 9382 89874001
Biliary colic 17.10 10.88 6 745058 4057 89879326
Infected seroma 17.09 10.88 10 745054 77 89883306
Genital abscess 17.09 10.88 17 745047 309 89883074
Antinuclear antibody negative 17.03 10.88 16 745048 270 89883113
Injection site urticaria 17.03 10.88 83 744981 17928 89865455
Red blood cells urine positive 16.98 10.88 3 745061 3222 89880161
Incorrect drug administration rate 16.96 10.88 11 745053 5212 89878171
Disseminated varicella zoster virus infection 16.95 10.88 20 745044 444 89882939
Oxygen saturation abnormal 16.94 10.88 7 745057 4281 89879102
Diabetes insipidus 16.88 10.88 3 745061 3209 89880174
Renal tubular disorder 16.85 10.88 3 745061 3204 89880179
Ovarian cyst 16.84 10.88 79 744985 17239 89866144
Occult blood positive 16.83 10.88 6 745058 4017 89879366
Skeletal dysplasia 16.77 10.88 11 745053 106 89883277
Stress at work 16.76 10.88 36 745028 1353 89882030
Screaming 16.73 10.88 5 745059 3745 89879638
Diverticulum intestinal 16.71 10.88 31 745033 9111 89874272
Vulvovaginal pain 16.70 10.88 4 745060 3470 89879913
Malabsorption 16.68 10.88 11 745053 5167 89878216
Appetite disorder 16.66 10.88 31 745033 9102 89874281
Hepatomegaly 16.66 10.88 55 745009 13271 89870112
Tenderness 16.64 10.88 312 744752 26556 89856827
Infective exacerbation of bronchiectasis 16.61 10.88 20 745044 454 89882929
Sleep disorder due to a general medical condition 16.60 10.88 263 744801 44475 89838908
Folate deficiency 16.54 10.88 3 745061 3162 89880221
Anaphylactoid reaction 16.54 10.88 8 745056 4460 89878923
Bladder cancer 16.53 10.88 14 745050 5787 89877596
Blood disorder 16.49 10.88 24 745040 7766 89875617
Gastric cancer 16.43 10.88 11 745053 5125 89878258
Eye movement disorder 16.42 10.88 16 745048 6182 89877201
Dry mouth 16.39 10.88 1741 743323 182318 89701065
Azotaemia 16.39 10.88 12 745052 5336 89878047
Abortion incomplete 16.36 10.88 3 745061 3137 89880246
Product dose omission in error 16.35 10.88 100 744964 20403 89862980
Spinal meningioma benign 16.35 10.88 11 745053 111 89883272
Hypoxic-ischaemic encephalopathy 16.33 10.88 9 745055 4659 89878724
Candida infection 16.33 10.88 190 744874 33867 89849516
Cardiopulmonary failure 16.28 10.88 7 745057 4181 89879202
Respiratory acidosis 16.24 10.88 26 745038 8093 89875290
Tooth extraction 16.19 10.88 45 745019 11468 89871915
Blood thyroid stimulating hormone decreased 16.18 10.88 14 745050 5726 89877657
Acne 16.12 10.88 153 744911 28354 89855029
Coombs positive haemolytic anaemia 16.08 10.88 20 745044 470 89882913
Areflexia 16.07 10.88 5 745059 3648 89879735
Incorrect product administration duration 16.06 10.88 93 744971 19229 89864154
Double stranded DNA antibody positive 16.06 10.88 19 745045 423 89882960
Infectious crystalline keratopathy 16.05 10.88 6 745058 13 89883370
Atrioventricular block 16.01 10.88 30 745034 8785 89874598
Colitis ulcerative 16.01 10.88 375 744689 59891 89823492
Biliary obstruction 15.91 10.88 4 745060 3358 89880025
Trigeminal neuralgia 15.91 10.88 7 745057 4124 89879259
Thrombophlebitis 15.91 10.88 10 745054 4818 89878565
Herpes simplex hepatitis 15.88 10.88 22 745042 576 89882807
Intervertebral disc compression 15.87 10.88 33 745031 1212 89882171
Protein total decreased 15.85 10.88 21 745043 7068 89876315
Abdominal tenderness 15.84 10.88 33 745031 9291 89874092
Optic neuritis 15.82 10.88 35 745029 9643 89873740
Congenital cardiovascular anomaly 15.82 10.88 20 745044 478 89882905
Allergy to chemicals 15.80 10.88 67 744997 3687 89879696
Pleuropericarditis 15.80 10.88 17 745047 340 89883043
Seroma 15.78 10.88 3 745061 3057 89880326
Peritonitis 15.77 10.88 96 744968 19609 89863774
Cranial nerve injury 15.75 10.88 6 745058 14 89883369
Skin abrasion 15.74 10.88 44 745020 11191 89872192
Gingival hyperpigmentation 15.62 10.88 5 745059 5 89883378
Chorioretinitis 15.54 10.88 26 745038 807 89882576
Bronchitis 15.53 10.88 1065 743999 151862 89731521
Haemolytic anaemia 15.52 10.88 47 745017 11650 89871733
Humerus fracture 15.50 10.88 36 745028 9749 89873634
Respiratory syncytial virus infection 15.47 10.88 40 745024 10440 89872943
Urinary tract infection enterococcal 15.46 10.88 3 745061 3013 89880370
Clostridium test positive 15.43 10.88 13 745051 5388 89877995
Coeliac disease 15.40 10.88 478 744586 44132 89839251
Forced expiratory volume decreased 15.38 10.88 15 745049 5793 89877590
Renal pain 15.37 10.88 25 745039 7734 89875649
Natural killer-cell leukaemia 15.36 10.88 10 745054 95 89883288
Metabolic alkalosis 15.36 10.88 5 745059 3544 89879839
Economic problem 15.34 10.88 4 745060 3277 89880106
Blood potassium abnormal 15.30 10.88 3 745061 2991 89880392
Localised oedema 15.27 10.88 17 745047 6177 89877206
Catheter site pain 15.25 10.88 14 745050 5565 89877818
Communication disorder 15.24 10.88 4 745060 3262 89880121
Multiple epiphyseal dysplasia 15.19 10.88 10 745054 97 89883286
Neoplasm recurrence 15.19 10.88 4 745060 3255 89880128
Electrocardiogram ST segment elevation 15.16 10.88 7 745057 4009 89879374
Angina unstable 15.13 10.88 22 745042 7121 89876262
Poor quality product administered 15.11 10.88 7 745057 4001 89879382
Macular oedema 15.06 10.88 11 745053 4898 89878485
Peroneal nerve palsy 15.04 10.88 15 745049 5733 89877650
Venous thrombosis 15.01 10.88 14 745050 5523 89877860
Dermatitis exfoliative 15.01 10.88 14 745050 5522 89877861
Tongue discolouration 14.98 10.88 5 745059 3488 89879895
Aortic stenosis 14.96 10.88 18 745046 6318 89877065
Vitamin B12 deficiency 14.94 10.88 24 745040 7462 89875921
Inadequate analgesia 14.94 10.88 4 745060 3220 89880163
Fracture delayed union 14.93 10.88 50 745014 2456 89880927
Lepromatous leprosy 14.93 10.88 6 745058 17 89883366
Ganglioneuroma 14.91 10.88 11 745053 130 89883253
Injection site rash 14.87 10.88 127 744937 24046 89859337
Eosinophil count decreased 14.86 10.88 4 745060 3208 89880175
End stage renal disease 14.85 10.88 30 745034 8541 89874842
Hepatitis toxic 14.84 10.88 6 745058 3719 89879664
Larynx irritation 14.83 10.88 12 745052 164 89883219
Gastroenteritis 14.82 10.88 161 744903 29068 89854315
Accident 14.81 10.88 103 744961 6851 89876532
Adrenal insufficiency 14.77 10.88 336 744728 29585 89853798
Blood pressure systolic decreased 14.77 10.88 34 745030 9236 89874147
Dermatitis bullous 14.75 10.88 40 745024 10276 89873107
Kidney transplant rejection 14.75 10.88 11 745053 4846 89878537
Ulcer haemorrhage 14.73 10.88 301 744763 26020 89857363
Behaviour disorder 14.73 10.88 10 745054 4625 89878758
Hereditary motor and sensory neuropathy 14.69 10.88 10 745054 103 89883280
Long QT syndrome 14.69 10.88 69 744995 3968 89879415
Tooth disorder 14.69 10.88 174 744890 30916 89852467
Cystic fibrosis 14.67 10.88 7 745057 3934 89879449
Premature delivery 14.64 10.88 420 744644 38342 89845041
Gonorrhoea 14.64 10.88 11 745053 134 89883249
Salt craving 14.64 10.88 11 745053 134 89883249
Subcutaneous drug absorption impaired 14.58 10.88 173 744891 13372 89870011
Haemolysis 14.56 10.88 30 745034 8480 89874903
Obstruction 14.55 10.88 7 745057 3914 89879469
Odynophagia 14.54 10.88 33 745031 9010 89874373
Product administered at inappropriate site 14.52 10.88 8 745056 4143 89879240
Onychoclasis 14.51 10.88 24 745040 7375 89876008
Heart block congenital 14.45 10.88 6 745058 19 89883364
Iridocyclitis 14.42 10.88 6 745058 3655 89879728
Serum ferritin increased 14.42 10.88 24 745040 7357 89876026
Intracranial pressure increased 14.40 10.88 21 745043 6790 89876593
Abdominal hernia 14.37 10.88 16 745048 5812 89877571
Coloboma 14.30 10.88 10 745054 108 89883275
Tearfulness 14.29 10.88 11 745053 4769 89878614
Bilirubin conjugated increased 14.29 10.88 4 745060 3126 89880257
Myositis 14.20 10.88 278 744786 23850 89859533
Gastrointestinal sounds abnormal 14.17 10.88 10 745054 4533 89878850
Acute respiratory distress syndrome 14.16 10.88 159 744905 28527 89854856
Symptom masked 14.13 10.88 28 745036 993 89882390
Inflammatory bowel disease 14.11 10.88 13 745051 5158 89878225
Systemic candida 14.09 10.88 12 745052 4947 89878436
Limb operation 14.08 10.88 74 744990 4453 89878930
Throat clearing 14.07 10.88 7 745057 3840 89879543
Retinal deposits 14.05 10.88 9 745055 83 89883300
Endocarditis 14.02 10.88 23 745041 7090 89876293
Monocyte count abnormal 14.00 10.88 14 745050 256 89883127
Palmoplantar pustulosis 13.99 10.88 21 745043 593 89882790
Muscle haemorrhage 13.98 10.88 5 745059 3341 89880042
Tenosynovitis stenosans 13.97 10.88 67 744997 3886 89879497
Negative cardiac inotropic effect 13.97 10.88 5 745059 9 89883374
Overlap syndrome 13.96 10.88 119 744945 8429 89874954
Retinal disorder 13.93 10.88 41 745023 1878 89881505
Culture urine positive 13.93 10.88 7 745057 3818 89879565
Pulmonary haemorrhage 13.92 10.88 28 745036 7985 89875398
Menstrual disorder 13.91 10.88 18 745046 6120 89877263
Skin weeping 13.91 10.88 3 745061 2797 89880586
Complement factor C3 decreased 13.90 10.88 15 745049 301 89883082
Pneumonia klebsiella 13.89 10.88 4 745060 3068 89880315
Drug effective for unapproved indication 13.87 10.88 112 744952 7806 89875577
Plasmacytoma 13.86 10.88 3 745061 2790 89880593
Oral lichen planus 13.84 10.88 24 745040 767 89882616
Deafness neurosensory 13.80 10.88 100 744964 6741 89876642
Gastroenteritis cryptosporidial 13.78 10.88 9 745055 86 89883297
Juvenile idiopathic arthritis 13.77 10.88 67 744997 3910 89879473
Abdominal pain upper 13.73 10.88 3013 742051 329661 89553722
Catheter site erythema 13.72 10.88 12 745052 4882 89878501
Extradural abscess 13.72 10.88 32 745032 1272 89882111
Immunosuppressant drug level increased 13.70 10.88 11 745053 4669 89878714
Enthesophyte 13.68 10.88 11 745053 149 89883234
Urticarial vasculitis 13.67 10.88 28 745036 1017 89882366
Rheumatoid factor quantitative increased 13.64 10.88 5 745059 10 89883373
Hordeolum 13.63 10.88 12 745052 4866 89878517
Disease complication 13.59 10.88 7 745057 3765 89879618
Gout 13.56 10.88 82 744982 16777 89866606
Urine leukocyte esterase positive 13.55 10.88 5 745059 3277 89880106
Androgenetic alopecia 13.55 10.88 12 745052 187 89883196
Product administered to patient of inappropriate age 13.54 10.88 11 745053 4642 89878741
Adenoiditis 13.53 10.88 7 745057 41 89883342
Thyroid function test abnormal 13.51 10.88 8 745056 3981 89879402
Peripheral ischaemia 13.49 10.88 16 745048 5651 89877732
Catatonia 13.48 10.88 18 745046 6038 89877345
Mouth swelling 13.46 10.88 16 745048 5646 89877737
Potentiating drug interaction 13.46 10.88 16 745048 5646 89877737
Vitreous floaters 13.44 10.88 26 745038 7523 89875860
Defaecation urgency 13.44 10.88 19 745045 6223 89877160
Bezoar 13.44 10.88 3 745061 2731 89880652
Facial bones fracture 13.43 10.88 7 745057 3740 89879643
Swelling of eyelid 13.41 10.88 15 745049 5439 89877944
Neutrophil percentage increased 13.41 10.88 4 745060 2999 89880384
Feeling of body temperature change 13.39 10.88 16 745048 5633 89877750
Congestive cardiomyopathy 13.38 10.88 25 745039 7329 89876054
Atypical femur fracture 13.38 10.88 20 745044 6401 89876982
Autoimmune haemolytic anaemia 13.37 10.88 16 745048 5629 89877754
Skin laceration 13.37 10.88 143 744921 25892 89857491
Decreased interest 13.36 10.88 10 745054 4397 89878986
Facial paresis 13.35 10.88 8 745056 3955 89879428
Neutrophilic dermatosis 13.33 10.88 14 745050 272 89883111
Bacterial pericarditis 13.32 10.88 5 745059 11 89883372
Right ventricular diastolic collapse 13.32 10.88 5 745059 11 89883372
West Nile viral infection 13.31 10.88 19 745045 512 89882871
Gastrointestinal infection 13.30 10.88 46 745018 10944 89872439
Trismus 13.30 10.88 12 745052 4809 89878574
Photopsia 13.28 10.88 13 745051 5011 89878372
Creatinine urine abnormal 13.26 10.88 7 745057 43 89883340
Diverticulitis 13.25 10.88 475 744589 44712 89838671
Injection site induration 13.23 10.88 43 745021 10425 89872958
Latent tuberculosis 13.22 10.88 54 745010 2922 89880461
Short stature 13.22 10.88 28 745036 1042 89882341
Infusion site pruritus 13.21 10.88 22 745042 6743 89876640
Hepatic cyst 13.17 10.88 21 745043 6547 89876836
Eye inflammation 13.16 10.88 28 745036 7823 89875560
Duodenitis 13.10 10.88 10 745054 4353 89879030
Sputum increased 13.09 10.88 4 745060 2953 89880430
Lung transplant 13.08 10.88 7 745057 3685 89879698
Blood chloride increased 13.07 10.88 5 745059 3205 89880178
Cryptococcal meningoencephalitis 13.04 10.88 11 745053 160 89883223
Feeling of despair 13.03 10.88 5 745059 3199 89880184
Electrocardiogram T wave inversion 13.03 10.88 7 745057 3676 89879707
Exposure via ingestion 12.96 10.88 3 745061 2664 89880719
Rheumatic disorder 12.96 10.88 59 745005 3349 89880034
Multiple system atrophy 12.94 10.88 12 745052 199 89883184
Chronic myeloid leukaemia 12.94 10.88 3 745061 2661 89880722
Catheter site haemorrhage 12.93 10.88 7 745057 3661 89879722
Hypercalcaemia 12.93 10.88 371 744693 33869 89849514
Platelet count abnormal 12.93 10.88 10 745054 4325 89879058
Systemic inflammatory response syndrome 12.90 10.88 21 745043 6495 89876888
Exposed bone in jaw 12.88 10.88 4 745060 2922 89880461
Hypertrophic cardiomyopathy 12.88 10.88 44 745020 2184 89881199
Bile duct stone 12.87 10.88 9 745055 4098 89879285
Cachexia 12.86 10.88 23 745041 6855 89876528
Gliosis 12.83 10.88 18 745046 477 89882906
Analgesic drug level increased 12.83 10.88 4 745060 2915 89880468
Gingival bleeding 12.78 10.88 71 744993 14832 89868551
Psoriasis 12.77 10.88 1043 744021 146711 89736672
Lung opacity 12.72 10.88 19 745045 6083 89877300
Neurological symptom 12.71 10.88 23 745041 6824 89876559
Blood pressure systolic abnormal 12.70 10.88 228 744836 19250 89864133
Complement factor C4 decreased 12.66 10.88 14 745050 289 89883094
Enterococcal infection 12.65 10.88 41 745023 9950 89873433
High grade B-cell lymphoma Burkitt-like lymphoma recurrent 12.65 10.88 8 745056 72 89883311
Lymphoma 12.64 10.88 63 745001 13528 89869855
Compression fracture 12.63 10.88 34 745030 8755 89874628
Portal hypertension 12.61 10.88 12 745052 4689 89878694
Humoral immune defect 12.60 10.88 16 745048 384 89882999
Infective tenosynovitis 12.60 10.88 16 745048 384 89882999
Microtia 12.57 10.88 16 745048 385 89882998
Lacunar infarction 12.57 10.88 6 745058 3371 89880012
Iatrogenic infection 12.49 10.88 5 745059 14 89883369
Biliary dyskinesia 12.48 10.88 3 745061 2596 89880787
Cytomegalovirus test positive 12.45 10.88 7 745057 3584 89879799
Hepatitis C 12.41 10.88 17 745047 5643 89877740
Abdominal wall haematoma 12.41 10.88 6 745058 3346 89880037
Undifferentiated connective tissue disease 12.40 10.88 10 745054 136 89883247
Extrasystoles 12.40 10.88 17 745047 5640 89877743
Fungaemia 12.40 10.88 6 745058 3344 89880039
Hypertension 12.39 10.88 4070 740994 453462 89429921
Tetany 12.37 10.88 3 745061 2581 89880802
Visual field defect 12.36 10.88 101 744963 7065 89876318
Congenital osteodystrophy 12.35 10.88 6 745058 30 89883353
Decreased activity 12.30 10.88 31 745033 8161 89875222
Porphyria acute 12.29 10.88 212 744852 17763 89865620
Erysipelas 12.28 10.88 36 745028 9016 89874367
Antinuclear antibody positive 12.24 10.88 123 744941 9118 89874265
Pyelonephritis acute 12.24 10.88 16 745048 5416 89877967
Hepatitis acute 12.23 10.88 47 745017 10840 89872543
Oral discomfort 12.23 10.88 136 744928 10347 89873036
Mycobacterial infection 12.21 10.88 43 745021 2167 89881216
Osteolysis 12.19 10.88 7 745057 3543 89879840
Gastric haemorrhage 12.19 10.88 25 745039 7078 89876305
Injection site warmth 12.17 10.88 89 744975 17426 89865957
Jaw cyst 12.16 10.88 10 745054 140 89883243
Sputum discoloured 12.16 10.88 108 744956 20283 89863100
Hyperaesthesia 12.15 10.88 46 745018 10656 89872727
Mean cell volume increased 12.14 10.88 14 745050 5007 89878376
Electrocardiogram ST segment depression 12.10 10.88 6 745058 3297 89880086
Pupillary reflex impaired 12.10 10.88 3 745061 2542 89880841
Rotator cuff repair 12.09 10.88 46 745018 2408 89880975
Anticoagulation drug level increased 12.07 10.88 14 745050 305 89883078
Attention deficit hyperactivity disorder 12.04 10.88 10 745054 4174 89879209
Phlebitis 12.04 10.88 27 745037 7403 89875980
Parainfluenzae virus infection 12.04 10.88 4 745060 2799 89880584
Fibrosis 12 10.88 87 744977 5865 89877518
Functional gastrointestinal disorder 12.00 10.88 77 744987 4985 89878398
Uterine cancer 11.99 10.88 16 745048 5369 89878014
Oxygen consumption increased 11.98 10.88 12 745052 4577 89878806
Erythema of eyelid 11.97 10.88 6 745058 3277 89880106
Lung adenocarcinoma 11.92 10.88 17 745047 5548 89877835
Contraindication to medical treatment 11.92 10.88 25 745039 924 89882459
Abnormal faeces 11.91 10.88 23 745041 6659 89876724
Iodine allergy 11.90 10.88 24 745040 862 89882521
Injection site discomfort 11.90 10.88 19 745045 5921 89877462
Pharyngitis streptococcal 11.88 10.88 59 745005 12683 89870700
Kidney infection 11.88 10.88 146 744918 25770 89857613
Carbohydrate antigen 125 increased 11.86 10.88 6 745058 3260 89880123
Angle closure glaucoma 11.85 10.88 4 745060 2771 89880612
Mediastinal cyst 11.85 10.88 7 745057 55 89883328
Bone disorder 11.84 10.88 261 744803 22859 89860524
Hair colour changes 11.84 10.88 7 745057 3487 89879896
Incorrect dose administered by device 11.83 10.88 18 745046 5719 89877664
Escherichia bacteraemia 11.82 10.88 18 745046 5717 89877666
Hypertonic bladder 11.78 10.88 11 745053 4337 89879046
Product distribution issue 11.76 10.88 8 745056 3697 89879686
Erythema nodosum 11.76 10.88 18 745046 5706 89877677
Product monitoring error 11.73 10.88 12 745052 4532 89878851
Blindness transient 11.72 10.88 12 745052 4531 89878852
Skin reaction 11.69 10.88 216 744848 18337 89865046
Infusion site rash 11.66 10.88 3 745061 2480 89880903
Pneumothorax 11.65 10.88 101 744963 19066 89864317
Product supply issue 11.63 10.88 5 745059 2987 89880396
Ileal stenosis 11.63 10.88 3 745061 2475 89880908
Lupus pleurisy 11.62 10.88 4 745060 6 89883377
Biopsy heart abnormal 11.62 10.88 4 745060 6 89883377
Pulmonary function test abnormal 11.61 10.88 4 745060 2735 89880648
Food poisoning 11.61 10.88 15 745049 5103 89878280
Gastrointestinal necrosis 11.60 10.88 6 745058 3219 89880164
Procedural complication 11.59 10.88 19 745045 5859 89877524
Pulmonary pain 11.58 10.88 15 745049 5099 89878284
Panic reaction 11.57 10.88 13 745051 4704 89878679
Self-medication 11.57 10.88 6 745058 3214 89880169
Libido decreased 11.57 10.88 5 745059 2977 89880406
Splenic infection 11.56 10.88 5 745059 18 89883365
Overwork 11.54 10.88 7 745057 58 89883325
Femur fracture 11.52 10.88 476 744588 45606 89837777
Anal fistula 11.52 10.88 11 745053 4290 89879093
Product taste abnormal 11.50 10.88 3 745061 2457 89880926
Postoperative wound infection 11.50 10.88 64 745000 13362 89870021
Persecutory delusion 11.49 10.88 6 745058 3202 89880181
Pneumatosis intestinalis 11.49 10.88 7 745057 3430 89879953
Middle ear effusion 11.48 10.88 4 745060 2717 89880666
Therapeutic reaction time decreased 11.48 10.88 8 745056 3650 89879733
Venoocclusive disease 11.46 10.88 3 745061 2452 89880931
Cerebellar syndrome 11.46 10.88 9 745055 3863 89879520
Self-injurious ideation 11.46 10.88 6 745058 3197 89880186
Vulvovaginal dryness 11.45 10.88 7 745057 3424 89879959
Autoimmune hepatitis 11.43 10.88 45 745019 10306 89873077
Ocular sarcoidosis 11.39 10.88 8 745056 87 89883296
Red blood cell count increased 11.39 10.88 8 745056 3635 89879748
Oral mucosal blistering 11.35 10.88 25 745039 6899 89876484
Tongue oedema 11.35 10.88 17 745047 5437 89877946
Hunger 11.35 10.88 23 745041 6540 89876843
Social avoidant behaviour 11.34 10.88 7 745057 3406 89879977
Alanine aminotransferase abnormal 11.34 10.88 80 744984 5346 89878037
Meningitis cryptococcal 11.31 10.88 37 745027 1796 89881587
Injection site discolouration 11.29 10.88 39 745025 9281 89874102
SARS-CoV-2 test positive 11.28 10.88 50 745014 11078 89872305
Chronic lymphocytic leukaemia 11.25 10.88 6 745058 3164 89880219
Culture tissue specimen positive 11.25 10.88 4 745060 7 89883376
Foetal movement disorder 11.25 10.88 4 745060 7 89883376
Product complaint 11.21 10.88 65 744999 13435 89869948
Arthritis salmonella 11.16 10.88 5 745059 20 89883363
Acute vestibular syndrome 11.16 10.88 5 745059 20 89883363
Impaired quality of life 11.14 10.88 129 744935 23015 89860368
Asthenopia 11.12 10.88 5 745059 2909 89880474
Night blindness 11.12 10.88 17 745047 488 89882895
Compartment syndrome 11.11 10.88 5 745059 2907 89880476
Abnormal weight gain 11.11 10.88 4 745060 2661 89880722
Rhinovirus infection 11.09 10.88 20 745044 5943 89877440
Solid organ transplant rejection 11.09 10.88 6 745058 39 89883344
Hypergammaglobulinaemia 11.07 10.88 19 745045 602 89882781
Gingival swelling 11.05 10.88 15 745049 4998 89878385
Idiopathic intracranial hypertension 11.02 10.88 8 745056 3573 89879810
Poor dental condition 10.99 10.88 17 745047 493 89882890
Pulmonary infarction 10.98 10.88 5 745059 2887 89880496
Lymphocyte percentage decreased 10.98 10.88 6 745058 3121 89880262
Appendicitis 10.97 10.88 45 745019 10186 89873197
Bundle branch block left 10.96 10.88 31 745033 7854 89875529
Brain herniation 10.95 10.88 11 745053 4189 89879194
Haemarthrosis 10.95 10.88 10 745054 3984 89879399
Vulvovaginal pruritus 10.94 10.88 10 745054 3983 89879400
Mycobacterium marinum infection 10.94 10.88 13 745051 291 89883092
Connective tissue disorder 10.93 10.88 36 745028 1753 89881630
Blood bicarbonate decreased 10.93 10.88 6 745058 3113 89880270
Varices oesophageal 10.92 10.88 9 745055 3770 89879613
Device related sepsis 10.92 10.88 14 745050 4779 89878604
Panic disorder 10.90 10.88 6 745058 3109 89880274
Swollen joint count 10.90 10.88 114 744950 8539 89874844

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 3024.50 12.91 4865 79772 633470 41903228
Rheumatoid arthritis 1798.21 12.91 1093 83544 41347 42495351
Drug ineffective 1794.39 12.91 3872 80765 626325 41910373
Joint swelling 1337.02 12.91 1095 83542 66927 42469771
Drug intolerance 1176.04 12.91 1094 83543 79330 42457368
Synovitis 1170.84 12.91 586 84051 14981 42521717
Contraindicated product administered 859.54 12.91 567 84070 24705 42511993
Treatment failure 788.32 12.91 785 83852 61839 42474859
C-reactive protein abnormal 581.74 12.91 309 84328 8952 42527746
Arthropathy 525.68 12.91 450 84187 29147 42507551
Apparent death 521.44 12.91 216 84421 3492 42533206
Therapeutic product effect decreased 511.26 12.91 501 84136 38649 42498049
Electrocardiogram QT prolonged 462.52 12.91 522 84115 47423 42489275
Bone erosion 447.53 12.91 204 84433 4199 42532499
Arthralgia 417.70 12.91 1115 83522 204123 42332575
Musculoskeletal stiffness 383.14 12.91 521 84116 57244 42479454
Pain 379.76 12.91 1207 83430 243641 42293057
Red blood cell sedimentation rate abnormal 368.79 12.91 171 84466 3665 42533033
Death 335.26 12.91 268 84369 470917 42065781
Red blood cell sedimentation rate increased 318.71 12.91 215 84422 9709 42526989
Hand deformity 307.31 12.91 150 84487 3618 42533080
Diverticulitis 305.71 12.91 296 84341 22477 42514221
C-reactive protein increased 274.84 12.91 470 84167 63090 42473608
Febrile neutropenia 261.68 12.91 31 84606 185672 42351026
Mobility decreased 256.36 12.91 333 84304 34973 42501725
Drug hypersensitivity 219.02 12.91 557 84080 98832 42437866
Peripheral swelling 193.79 12.91 501 84136 89769 42446929
Rheumatoid factor negative 191.15 12.91 73 84564 941 42535757
Rheumatoid factor positive 190.68 12.91 69 84568 757 42535941
Sleep disorder due to general medical condition, insomnia type 187.87 12.91 80 84557 1389 42535309
Loss of personal independence in daily activities 184.00 12.91 344 84293 49472 42487226
Anaemia 183.47 12.91 172 84465 280106 42256592
Long QT syndrome 177.46 12.91 98 84539 3069 42533629
Drug ineffective for unapproved indication 168.28 12.91 317 84320 45846 42490852
Drug tolerance decreased 166.05 12.91 85 84552 2275 42534423
Osteoarthritis 166.02 12.91 223 84414 24182 42512516
Onychoclasis 162.30 12.91 87 84550 2565 42534133
Arthritis 161.01 12.91 295 84342 41770 42494928
Malignant neoplasm progression 160.54 12.91 15 84622 108385 42428313
Gastrointestinal disorder 154.93 12.91 308 84329 46345 42490353
Knee arthroplasty 154.74 12.91 133 84504 8648 42528050
Constipation 153.60 12.91 65 84572 162226 42374472
Pulmonary thrombosis 152.33 12.91 129 84508 8219 42528479
Condition aggravated 148.51 12.91 955 83682 259799 42276899
Lymphoma 148.40 12.91 162 84475 14159 42522539
Polyarthritis 146.01 12.91 103 84534 5001 42531697
Limb discomfort 142.11 12.91 150 84487 12617 42524081
Anti-cyclic citrullinated peptide antibody positive 140.75 12.91 71 84566 1841 42534857
Herpes zoster 139.24 12.91 265 84372 38612 42498086
Rheumatoid nodule 139.13 12.91 82 84555 2913 42533785
Psoriatic arthropathy 138.56 12.91 207 84430 24760 42511938
Therapeutic product effect incomplete 138.30 12.91 380 84257 70559 42466139
Terminal state 137.65 12.91 94 84543 4329 42532369
Vomiting 128.82 12.91 237 84400 289486 42247212
Joint stiffness 128.74 12.91 140 84497 12182 42524516
Hepatitis 128.74 12.91 210 84427 27090 42509608
Intentional product use issue 128.49 12.91 373 84264 71460 42465238
Impaired work ability 127.42 12.91 138 84499 11953 42524745
Bone cyst 123.56 12.91 62 84575 1589 42535109
Grip strength decreased 123.06 12.91 81 84556 3507 42533191
Dehydration 123.00 12.91 64 84573 141703 42394995
Abdominal pain 120.87 12.91 120 84517 190351 42346347
Pyrexia 119.74 12.91 393 84244 393649 42143049
Acute kidney injury 118.18 12.91 357 84280 366980 42169718
Decreased appetite 116.56 12.91 127 84510 193010 42343688
Premature baby 109.03 12.91 178 84459 22975 42513723
Hypotension 107.29 12.91 219 84418 257412 42279286
Seizure 106.70 12.91 53 84584 120508 42416190
Joint lock 103.62 12.91 52 84585 1333 42535365
Acne cystic 102.93 12.91 40 84597 542 42536156
Overdose 101.41 12.91 41 84596 105223 42431475
Confusional state 101.33 12.91 110 84527 167487 42369211
Pain in extremity 99.09 12.91 573 84064 150031 42386667
Toxicity to various agents 98.63 12.91 191 84446 228945 42307753
Drug effective for unapproved indication 98.09 12.91 91 84546 6542 42530156
Photosensitivity reaction 92.44 12.91 120 84517 12582 42524116
Tooth loss 92.27 12.91 72 84565 4082 42532616
Blood pressure systolic abnormal 91.89 12.91 81 84556 5447 42531251
Drug specific antibody present 90.21 12.91 70 84567 3936 42532762
Intestinal sepsis 89.79 12.91 39 84598 712 42535986
Joint arthroplasty 89.10 12.91 42 84595 935 42535763
Diarrhoea 89.02 12.91 544 84093 460305 42076393
Foot deformity 87.74 12.91 76 84561 4992 42531706
Somnolence 84.84 12.91 93 84544 141012 42395686
Blood pressure diastolic abnormal 84.74 12.91 81 84556 6047 42530651
Drug dependence 83.56 12.91 181 84456 28913 42507785
Rhabdomyolysis 82.62 12.91 26 84611 77993 42458705
Hip arthroplasty 80.81 12.91 74 84563 5231 42531467
X-ray abnormal 79.40 12.91 32 84605 480 42536218
Disability 79.36 12.91 77 84560 5856 42530842
Neutropenia 78.40 12.91 175 84462 199256 42337442
Mass 75.53 12.91 90 84547 8649 42528049
Skin ulcer 75.50 12.91 161 84476 25440 42511258
Alanine aminotransferase abnormal 75.38 12.91 69 84568 4875 42531823
Gait inability 74.87 12.91 150 84487 22683 42514015
Lactic acidosis 73.47 12.91 4 84633 45257 42491441
Physical disability 73.42 12.91 46 84591 1827 42534871
Dyspnoea 73.18 12.91 547 84090 442074 42094624
Cytology abnormal 72.82 12.91 28 84609 368 42536330
Victim of child abuse 72.74 12.91 39 84598 1150 42535548
Foetal exposure during pregnancy 72.69 12.91 233 84404 47078 42489620
Low birth weight baby 72.37 12.91 94 84543 9861 42526837
Ascites 71.55 12.91 13 84624 56665 42480033
Epidural lipomatosis 70.04 12.91 44 84593 1756 42534942
Thrombocytopenia 69.95 12.91 173 84464 190106 42346592
Systemic lupus erythematosus 69.28 12.91 89 84548 9235 42527463
Arthritis bacterial 68.98 12.91 71 84566 5797 42530901
Hospitalisation 68.31 12.91 31 84606 74299 42462399
Lupus nephritis 68.17 12.91 29 84608 502 42536196
Blood pressure systolic increased 68.10 12.91 163 84474 27805 42508893
Joint ankylosis 67.79 12.91 42 84595 1635 42535063
Inflammation 67.59 12.91 183 84454 33664 42503034
Myelosuppression 67.52 12.91 3 84634 40458 42496240
Hyperkalaemia 67.29 12.91 38 84599 80420 42456278
Ill-defined disorder 67.07 12.91 118 84519 16178 42520520
Syncope 66.06 12.91 60 84577 99346 42437352
Juvenile idiopathic arthritis 65.79 12.91 49 84588 2590 42534108
Intestinal polyp 65.65 12.91 38 84599 1304 42535394
Nodule 63.99 12.91 100 84537 12434 42524264
Product use in unapproved indication 63.21 12.91 601 84036 183855 42352843
Hyponatraemia 63.06 12.91 65 84572 101397 42435301
Neoplasm malignant 62.48 12.91 139 84498 22604 42514094
Coma 62.02 12.91 15 84622 53539 42483159
Disease progression 61.52 12.91 120 84517 143536 42393162
General physical health deterioration 60.82 12.91 131 84506 151115 42385583
Bladder transitional cell carcinoma 60.78 12.91 47 84590 2629 42534069
COVID-19 treatment 60.33 12.91 22 84615 247 42536451
Loss of consciousness 59.88 12.91 57 84580 92297 42444401
Completed suicide 58.60 12.91 63 84574 96402 42440296
Blood glucose increased 58.54 12.91 37 84600 73662 42463036
Borderline leprosy 58.14 12.91 14 84623 27 42536671
Plasma cell myeloma 57.76 12.91 12 84625 47566 42489132
Swelling 57.76 12.91 239 84398 54646 42482052
Hallucination 57.69 12.91 21 84616 57486 42479212
Pulmonary fibrosis 57.07 12.91 148 84489 26533 42510165
Drug abuse 56.64 12.91 75 84562 104696 42432002
Platelet count decreased 56.57 12.91 119 84518 138462 42398236
Neutrophil count decreased 55.89 12.91 28 84609 63387 42473311
Localised infection 55.39 12.91 124 84513 20249 42516449
Joint range of motion decreased 54.48 12.91 72 84565 7681 42529017
Tuberculosis 53.56 12.91 82 84555 10017 42526681
Scleroderma renal crisis 53.50 12.91 23 84614 409 42536289
Skin laceration 53.01 12.91 98 84539 13960 42522738
Dizziness 52.91 12.91 285 84352 248969 42287729
Musculoskeletal pain 52.86 12.91 166 84471 33174 42503524
Blood creatinine increased 51.45 12.91 87 84550 109916 42426782
Deep vein thrombosis 50.65 12.91 293 84344 76664 42460034
Abdominal distension 50.45 12.91 41 84596 71694 42465004
Liver function test increased 50.25 12.91 118 84519 19880 42516818
Fall 49.85 12.91 268 84369 234252 42302446
Soft tissue swelling 49.33 12.91 26 84611 740 42535958
Disseminated strongyloidiasis 49.12 12.91 23 84614 504 42536194
Urinary tract infection 48.80 12.91 76 84561 99208 42437490
Orthostatic hypotension 48.70 12.91 3 84634 30567 42506131
Heart block congenital 48.34 12.91 13 84624 46 42536652
Epistaxis 47.24 12.91 38 84599 66788 42469910
Dactylitis 46.97 12.91 29 84608 1122 42535576
Therapeutic response decreased 46.11 12.91 170 84467 36842 42499856
Gastrointestinal haemorrhage 45.97 12.91 77 84560 97649 42439049
Alopecia 45.70 12.91 145 84492 29131 42507567
Renal impairment 45.53 12.91 94 84543 110134 42426564
Medication error 45.49 12.91 6 84631 33148 42503550
Seronegative arthritis 45.33 12.91 29 84608 1195 42535503
Gastric disorder 44.81 12.91 83 84554 11839 42524859
Musculoskeletal discomfort 44.80 12.91 73 84564 9403 42527295
Blood pressure fluctuation 44.53 12.91 136 84501 26772 42509926
Infection 43.88 12.91 376 84261 111692 42425006
Neoplasm progression 42.94 12.91 4 84633 28996 42507702
Blood pressure decreased 42.71 12.91 32 84605 58300 42478398
Hepatic enzyme increased 42.51 12.91 192 84445 45592 42491106
Rheumatoid lung 42.14 12.91 25 84612 899 42535799
Disturbance in attention 41.96 12.91 5 84632 29861 42506837
Hepatic cirrhosis 41.84 12.91 109 84528 19593 42517105
Joint effusion 41.80 12.91 55 84582 5842 42530856
Osteolysis 41.51 12.91 43 84594 3537 42533161
Limb deformity 41.16 12.91 21 84616 558 42536140
Therapeutic product ineffective for unapproved indication 40.46 12.91 13 84624 96 42536602
Epilepsy 40.43 12.91 3 84634 26168 42510530
Oral surgery 39.99 12.91 21 84616 593 42536105
Aggression 39.67 12.91 19 84618 44144 42492554
Hypertransaminasaemia 39.51 12.91 68 84569 9159 42527539
Dyskinesia 38.97 12.91 3 84634 25387 42511311
Maternal exposure during pregnancy 38.91 12.91 58 84579 6920 42529778
Pancytopenia 38.73 12.91 113 84524 117630 42419068
Hepatic fibrosis 38.56 12.91 48 84589 4824 42531874
Restlessness 38.48 12.91 6 84631 29243 42507455
Herpes simplex viraemia 38.31 12.91 13 84624 116 42536582
Hepatic function abnormal 38.13 12.91 28 84609 51539 42485159
Basal cell carcinoma 37.71 12.91 115 84522 22618 42514080
Abdominal discomfort 37.48 12.91 267 84370 74988 42461710
Anxiety 37.41 12.91 116 84521 118444 42418254
Skin mass 37.41 12.91 47 84590 4769 42531929
Prerenal failure 37.18 12.91 34 84603 2399 42534299
Cardiac failure 37.04 12.91 100 84537 106756 42429942
Medical device implantation 36.96 12.91 20 84617 601 42536097
Product use issue 36.89 12.91 270 84367 76481 42460217
Agitation 36.87 12.91 44 84593 64270 42472428
Tenosynovitis 36.75 12.91 46 84591 4649 42532049
Immobile 36.19 12.91 36 84601 2822 42533876
Red blood cell sedimentation rate 36.11 12.91 24 84613 1056 42535642
No adverse event 35.74 12.91 163 84474 38858 42497840
Ventricular fibrillation 35.74 12.91 8 84629 30115 42506583
Neurotoxicity 35.73 12.91 3 84634 23648 42513050
C-reactive protein decreased 35.65 12.91 32 84605 2204 42534494
Suicide attempt 35.44 12.91 24 84613 46076 42490622
Dysphagia 35.40 12.91 56 84581 72663 42464035
Wheezing 35.28 12.91 34 84603 54747 42481951
Blood bilirubin increased 35.25 12.91 20 84617 42232 42494466
Hepatic enzyme abnormal 34.93 12.91 39 84598 3493 42533205
Cardiac arrest 34.46 12.91 107 84530 109213 42427485
Type 1 lepra reaction 34.42 12.91 10 84627 50 42536648
Granuloma skin 34.28 12.91 24 84613 1151 42535547
Unresponsive to stimuli 34.07 12.91 10 84627 31393 42505305
Shoulder operation 33.92 12.91 26 84611 1435 42535263
Maculopathy 33.81 12.91 23 84614 1052 42535646
Liver injury 33.78 12.91 99 84538 19049 42517649
Maternal exposure before pregnancy 33.77 12.91 23 84614 1054 42535644
Disorientation 33.70 12.91 15 84622 36374 42500324
External auditory canal atresia 33.33 12.91 13 84624 178 42536520
Flushing 33.15 12.91 16 84621 37012 42499686
Immobilisation syndrome 33.07 12.91 17 84620 459 42536239
Intestinal obstruction 32.65 12.91 7 84630 27151 42509547
Haematuria 32.65 12.91 40 84597 57759 42478939
Septic shock 32.36 12.91 85 84552 91587 42445111
International normalised ratio increased 32.07 12.91 29 84608 48139 42488559
Vitamin D deficiency 31.35 12.91 57 84580 8016 42528682
Asthenia 31.30 12.91 382 84255 280411 42256287
Blood pressure diastolic increased 31.17 12.91 50 84587 6355 42530343
Food intolerance 31.05 12.91 26 84611 1630 42535068
Urticaria 30.88 12.91 252 84385 73784 42462914
Diabetic ketoacidosis 30.80 12.91 4 84633 22363 42514335
Circulatory collapse 30.75 12.91 5 84632 23631 42513067
Anaphylactic reaction 30.58 12.91 24 84613 42719 42493979
Panniculitis 30.48 12.91 29 84608 2152 42534546
Infection reactivation 30.33 12.91 29 84608 2165 42534533
C-reactive protein 30.32 12.91 10 84627 81 42536617
Appendicitis 30.10 12.91 3 84634 20610 42516088
Product dose omission issue 29.75 12.91 182 84455 154183 42382515
Incorrect dose administered 29.56 12.91 37 84600 52937 42483761
Cryopyrin associated periodic syndrome 29.10 12.91 10 84627 93 42536605
Respiratory depression 29.03 12.91 93 84544 18775 42517923
Chondropathy 28.96 12.91 22 84615 1198 42535500
Dysarthria 28.93 12.91 22 84615 39785 42496913
Hyperglycaemia 28.91 12.91 29 84608 45830 42490868
Cutaneous lupus erythematosus 28.77 12.91 19 84618 827 42535871
Hypophagia 28.49 12.91 9 84628 26947 42509751
Sensitivity to weather change 28.24 12.91 27 84610 2016 42534682
Full blood count abnormal 28.16 12.91 12 84625 29864 42506834
Fatigue 28.13 12.91 655 83982 434986 42101712
Lethargy 28.04 12.91 31 84606 46859 42489839
Nail bed bleeding 27.95 12.91 15 84622 443 42536255
Acute lung injury 27.85 12.91 24 84613 1565 42535133
Malaise 27.85 12.91 278 84359 211878 42324820
Subdural haematoma 27.74 12.91 6 84631 23132 42513566
Tubulointerstitial nephritis 27.68 12.91 14 84623 31534 42505164
Sedation 27.54 12.91 13 84624 30462 42506236
Cerebrovascular accident 27.27 12.91 100 84537 97060 42439638
Blood parathyroid hormone decreased 27.16 12.91 24 84613 1619 42535079
Bone marrow failure 27.13 12.91 16 84621 33077 42503621
Haematemesis 27.11 12.91 13 84624 30186 42506512
Irritability 26.99 12.91 11 84626 28117 42508581
Pneumonia 26.90 12.91 636 84001 421513 42115185
Gout 26.88 12.91 11 84626 28044 42508654
Cardio-respiratory arrest 26.83 12.91 47 84590 58589 42478109
Cardiogenic shock 26.80 12.91 19 84618 35621 42501077
Foetal growth restriction 26.76 12.91 42 84595 5241 42531457
Blood urea increased 26.68 12.91 16 84621 32777 42503921
Stent placement 26.30 12.91 42 84595 5318 42531380
Urinary retention 26.26 12.91 27 84610 42187 42494511
Fine motor skill dysfunction 26.15 12.91 27 84610 2212 42534486
Drug use disorder 25.99 12.91 61 84576 10272 42526426
Lymphoedema 25.99 12.91 40 84597 4908 42531790
Cytomegalovirus infection 25.95 12.91 16 84621 32290 42504408
Muscle spasms 25.87 12.91 86 84551 85958 42450740
Skin injury 25.84 12.91 29 84608 2612 42534086
Therapy non-responder 25.80 12.91 188 84449 53171 42483527
Colitis ulcerative 25.51 12.91 10 84627 26165 42510533
Full blood count decreased 25.34 12.91 5 84632 20555 42516143
Disseminated varicella zoster virus infection 25.26 12.91 17 84620 764 42535934
Depressed level of consciousness 25.24 12.91 35 84602 47935 42488763
Erectile dysfunction 25.14 12.91 9 84628 24904 42511794
Product quality issue 25.10 12.91 3 84634 17879 42518819
Nodular regenerative hyperplasia 25.10 12.91 19 84618 1029 42535669
Dyspepsia 24.98 12.91 154 84483 41198 42495500
Troponin increased 24.87 12.91 4 84633 19058 42517640
Liver disorder 24.81 12.91 149 84488 39495 42497203
Agranulocytosis 24.81 12.91 15 84622 30597 42506101
Microcephaly 24.76 12.91 18 84619 916 42535782
Neck mass 24.72 12.91 24 84613 1826 42534872
Ocular toxicity 24.70 12.91 13 84624 369 42536329
Atrial fibrillation 24.64 12.91 169 84468 139424 42397274
Strongyloidiasis 24.32 12.91 32 84605 3399 42533299
Oral disorder 24.02 12.91 38 84599 4774 42531924
Hypophosphataemia 23.98 12.91 6 84631 20939 42515759
PaO2/FiO2 ratio decreased 23.77 12.91 7 84630 37 42536661
Vision blurred 23.71 12.91 44 84593 53655 42483043
Neck deformity 23.64 12.91 9 84628 115 42536583
Dysgeusia 23.46 12.91 20 84617 34169 42502529
Palmar-plantar erythrodysaesthesia syndrome 23.37 12.91 6 84631 20576 42516122
Retinal toxicity 23.36 12.91 14 84623 513 42536185
Medium-chain acyl-coenzyme A dehydrogenase deficiency 23.17 12.91 7 84630 41 42536657
Latent tuberculosis 23.00 12.91 22 84615 1643 42535055
Pneumatosis intestinalis 23.00 12.91 37 84600 4715 42531983
Respiratory arrest 22.94 12.91 14 84623 28410 42508288
Fragile X syndrome 22.89 12.91 7 84630 43 42536655
Thrombocytosis 22.86 12.91 37 84600 4738 42531960
Abnormal behaviour 22.82 12.91 12 84625 26439 42510259
Iris coloboma 22.82 12.91 6 84631 19 42536679
Encephalitis Japanese B 22.82 12.91 6 84631 19 42536679
Osteonecrosis of jaw 22.72 12.91 5 84632 19044 42517654
Interstitial lung disease 22.67 12.91 247 84390 78215 42458483
Retinal coloboma 22.58 12.91 6 84631 20 42536678
Diffuse idiopathic skeletal hyperostosis 22.36 12.91 7 84630 47 42536651
Pancreatitis 22.33 12.91 32 84605 43236 42493462
Bradycardia 22.05 12.91 91 84546 85393 42451305
Coronary artery disease 22.01 12.91 46 84591 53674 42483024
Ataxia 21.92 12.91 3 84634 16122 42520576
Squamous cell carcinoma 21.83 12.91 66 84571 12916 42523782
Blood potassium increased 21.83 12.91 5 84632 18531 42518167
Injection related reaction 21.35 12.91 14 84623 602 42536096
Antiphospholipid syndrome 21.12 12.91 14 84623 613 42536085
Sarcoidosis 21.10 12.91 31 84606 3651 42533047
Cognitive disorder 21.09 12.91 22 84615 34150 42502548
Cerebral haemorrhage 20.93 12.91 28 84609 38938 42497760
Clostridium difficile colitis 20.91 12.91 8 84629 21244 42515454
Lupus pneumonitis 20.87 12.91 7 84630 60 42536638
Tenderness 20.79 12.91 51 84586 8832 42527866
Melaena 20.65 12.91 28 84609 38718 42497980
External ear disorder 20.65 12.91 6 84631 30 42536668
Nightmare 20.63 12.91 12 84625 25000 42511698
Tachycardia 20.62 12.91 117 84520 100970 42435728
Ossicle disorder 20.33 12.91 6 84631 32 42536666
Therapeutic response unexpected 20.22 12.91 59 84578 11322 42525376
Glucose-6-phosphate dehydrogenase deficiency 20.19 12.91 10 84627 249 42536449
Trisomy 8 20.01 12.91 7 84630 69 42536629
Hepatic steatosis 19.94 12.91 90 84547 21358 42515340
Hypofibrinogenaemia 19.94 12.91 22 84615 1945 42534753
Suicidal ideation 19.93 12.91 41 84596 48120 42488578
Enthesopathy 19.91 12.91 35 84602 4793 42531905
White blood cell count increased 19.85 12.91 37 84600 45050 42491648
Tender joint count decreased 19.80 12.91 10 84627 260 42536438
Swollen joint count decreased 19.80 12.91 10 84627 260 42536438
Meningitis noninfective 19.74 12.91 5 84632 13 42536685
Acute myocardial infarction 19.72 12.91 55 84582 58110 42478588
Degenerative bone disease 19.66 12.91 7 84630 73 42536625
Arthrodesis 19.64 12.91 13 84624 568 42536130
Pneumonia aspiration 19.59 12.91 44 84593 50034 42486664
Blood lactate dehydrogenase increased 19.49 12.91 14 84623 26067 42510631
Angioedema 19.47 12.91 34 84603 42443 42494255
Tender joint count 19.47 12.91 5 84632 14 42536684
Jaundice 19.46 12.91 24 84613 34565 42502133
Delusion 19.43 12.91 3 84634 14731 42521967
Haemorrhoids 19.38 12.91 5 84632 17092 42519606
Stevens-Johnson syndrome 19.22 12.91 10 84627 22168 42514530
Acute cutaneous lupus erythematosus 19.16 12.91 7 84630 79 42536619
Unevaluable event 19.07 12.91 24 84613 34264 42502434
Rebound effect 19.04 12.91 44 84593 7335 42529363
Double stranded DNA antibody positive 19.02 12.91 9 84628 202 42536496
Hallucination, visual 18.94 12.91 9 84628 21011 42515687
Retinopathy 18.90 12.91 23 84614 2258 42534440
Preterm premature rupture of membranes 18.85 12.91 7 84630 83 42536615
Child abuse 18.82 12.91 15 84622 877 42535821
Aspartate aminotransferase increased 18.76 12.91 84 84553 77079 42459619
Bone hypertrophy 18.74 12.91 10 84627 292 42536406
Q fever 18.57 12.91 8 84629 143 42536555
Haemorrhage 18.57 12.91 60 84577 60503 42476195
Mononeuropathy multiplex 18.45 12.91 12 84625 509 42536189
Anaphylactic shock 18.40 12.91 12 84625 23505 42513193
Peritonitis 18.35 12.91 7 84630 18626 42518072
Visual acuity reduced 18.30 12.91 6 84631 17544 42519154
Wrist surgery 18.27 12.91 8 84629 149 42536549
Drug withdrawal syndrome 18.26 12.91 10 84627 21539 42515159
Disease recurrence 18.23 12.91 111 84526 29567 42507131
Tooth injury 18.18 12.91 17 84620 1234 42535464
Neonatal lupus erythematosus 18.13 12.91 4 84633 4 42536694
Andersen-Tawil syndrome 18.13 12.91 4 84633 4 42536694
Acute respiratory distress syndrome 18.11 12.91 112 84525 29996 42506702
Chronic kidney disease 18.08 12.91 42 84595 47199 42489499
Mucosal inflammation 18.02 12.91 45 84592 49329 42487369
Antinuclear antibody positive 17.98 12.91 19 84618 1599 42535099
Altered state of consciousness 17.87 12.91 19 84618 29240 42507458
Hypoglycaemia 17.86 12.91 60 84577 59794 42476904
Psychotic disorder 17.81 12.91 19 84618 29189 42507509
Dysstasia 17.79 12.91 65 84572 14021 42522677
Oral pustule 17.78 12.91 9 84628 235 42536463
Swollen tongue 17.78 12.91 10 84627 21221 42515477
Gastric ulcer 17.76 12.91 7 84630 18255 42518443
Tracheo-oesophageal fistula 17.74 12.91 12 84625 544 42536154
Eye disorder 17.65 12.91 57 84580 11555 42525143
Labyrinthitis 17.61 12.91 15 84622 963 42535735
Oedema peripheral 17.55 12.91 179 84458 135897 42400801
Product prescribing error 17.54 12.91 100 84537 26012 42510686
Cellulitis 17.53 12.91 63 84574 61522 42475176
Faeces discoloured 17.42 12.91 6 84631 17008 42519690
Transient ischaemic attack 17.36 12.91 25 84612 33714 42502984
Angina pectoris 17.30 12.91 24 84613 32872 42503826
Tendon disorder 17.24 12.91 27 84610 3362 42533336
Electrocardiogram PR prolongation 17.21 12.91 15 84622 993 42535705
Neutrophil count increased 17.06 12.91 9 84628 19795 42516903
Neutrophil Pelger-Huet anomaly present 16.98 12.91 9 84628 259 42536439
Malnutrition 16.97 12.91 4 84633 14538 42522160
Cartilage injury 16.93 12.91 12 84625 587 42536111
Hypoalbuminaemia 16.88 12.91 5 84632 15605 42521093
Anticoagulation drug level increased 16.87 12.91 12 84625 590 42536108
Underdose 16.85 12.91 6 84631 16660 42520038
Eczema 16.82 12.91 26 84611 34060 42502638
Hyperhidrosis 16.76 12.91 108 84529 90404 42446294
Presyncope 16.75 12.91 12 84625 22375 42514323
Enzyme abnormality 16.74 12.91 9 84628 267 42536431
Optic nerve operation 16.61 12.91 11 84626 481 42536217
Meningitis 16.51 12.91 36 84601 5773 42530925
Pulmonary toxicity 16.48 12.91 46 84591 8609 42528089
Electrocardiogram QRS complex prolonged 16.45 12.91 36 84601 5787 42530911
Encephalopathy 16.42 12.91 36 84601 41297 42495401
Hyperphosphataemia 16.37 12.91 3 84634 13001 42523697
Synovial cyst 16.33 12.91 23 84614 2606 42534092
Joint space narrowing 16.20 12.91 8 84629 198 42536500
Pancreatitis acute 16.19 12.91 26 84611 33538 42503160
Hepatic failure 16.13 12.91 32 84605 38068 42498630
Antiphospholipid antibodies positive 16.03 12.91 10 84627 394 42536304
Blood sodium decreased 16.02 12.91 8 84629 18154 42518544
Perineal infection 16.02 12.91 12 84625 640 42536058
Bursa removal 15.96 12.91 7 84630 131 42536567
Electrolyte imbalance 15.91 12.91 7 84630 17094 42519604
Hypocalcaemia 15.88 12.91 22 84615 30151 42506547
Gamma-glutamyltransferase increased 15.83 12.91 25 84612 32472 42504226
Urinary incontinence 15.71 12.91 12 84625 21656 42515042
T-cell receptor gene rearrangement test 15.67 12.91 3 84634 0 42536698
Activated partial thromboplastin time prolonged 15.62 12.91 6 84631 15897 42520801
Immune reconstitution inflammatory syndrome 15.61 12.91 50 84587 10093 42526605
Aspiration 15.60 12.91 8 84629 17878 42518820
Histoplasmosis disseminated 15.60 12.91 20 84617 2071 42534627
Face oedema 15.48 12.91 4 84633 13662 42523036
SAPHO syndrome 15.48 12.91 10 84627 419 42536279
Ankle deformity 15.40 12.91 8 84629 221 42536477
Poisoning 15.37 12.91 5 84632 14694 42522004
Fracture 15.36 12.91 43 84594 8060 42528638
Therapeutic product effect delayed 15.36 12.91 17 84620 1508 42535190
Polyneuropathy 15.32 12.91 9 84628 18652 42518046
Eye infection toxoplasmal 15.29 12.91 9 84628 319 42536379
Speech sound disorder 15.22 12.91 7 84630 147 42536551
Device issue 15.22 12.91 4 84633 13505 42523193
Tuberculin test positive 15.21 12.91 15 84622 1163 42535535
Liver function test 15.20 12.91 6 84631 85 42536613
Hypokalaemia 15.17 12.91 82 84555 71639 42465059
Accidental exposure to product 15.17 12.91 11 84626 20382 42516316
Miosis 15.11 12.91 4 84633 13442 42523256
Gastrointestinal infection 15.03 12.91 38 84599 6705 42529993
Device related infection 15 12.91 11 84626 20268 42516430
Cardiovascular disorder 14.97 12.91 4 84633 13361 42523337
Treatment noncompliance 14.81 12.91 33 84604 37639 42499059
Metabolic acidosis 14.79 12.91 53 84584 51805 42484893
Blood creatine phosphokinase increased 14.74 12.91 48 84589 48290 42488408
Metastases to liver 14.69 12.91 7 84630 16319 42520379
Ileus 14.66 12.91 10 84627 19129 42517569
Diabetes mellitus 14.61 12.91 183 84454 59904 42476794
Supraventricular tachyarrhythmia 14.59 12.91 6 84631 95 42536603
Lupus-like syndrome 14.51 12.91 24 84613 3130 42533568
Vertigo 14.41 12.91 29 84608 34318 42502380
Systemic lupus erythematosus rash 14.41 12.91 7 84630 167 42536531
Mental disorder 14.38 12.91 9 84628 18020 42518678
Tooth fracture 14.33 12.91 28 84609 4156 42532542
Drug reaction with eosinophilia and systemic symptoms 14.32 12.91 137 84500 41938 42494760
Oropharyngeal candidiasis 14.23 12.91 13 84624 916 42535782
Pulmonary oedema 14.18 12.91 56 84581 53216 42483482
Heart rate increased 14.17 12.91 56 84581 53199 42483499
Hypoxia 14.10 12.91 81 84556 69705 42466993
Ophthalmic herpes zoster 14.09 12.91 14 84623 1096 42535602
Blood pressure diastolic decreased 14.06 12.91 49 84588 10326 42526372
Wrong technique in product usage process 13.95 12.91 41 84596 42594 42494104
Exostosis 13.90 12.91 33 84604 5598 42531100
Blood potassium decreased 13.89 12.91 12 84625 20372 42516326
Viral vasculitis 13.89 12.91 6 84631 108 42536590
Metastases to bone 13.87 12.91 6 84631 14803 42521895
Viral load abnormal 13.84 12.91 6 84631 109 42536589
Dyspnoea exertional 13.81 12.91 52 84585 50096 42486602
Shoulder arthroplasty 13.80 12.91 12 84625 792 42535906
Drug tolerance 13.76 12.91 24 84613 3266 42533432
Intentional overdose 13.76 12.91 54 84583 51402 42485296
Hypovolaemia 13.72 12.91 3 84634 11482 42525216
Spinal cord oedema 13.63 12.91 8 84629 282 42536416
Pernio-like erythema 13.60 12.91 3 84634 3 42536695
Blood alkaline phosphatase increased 13.56 12.91 29 84608 33568 42503130
Nervousness 13.47 12.91 5 84632 13527 42523171
Acute pulmonary histoplasmosis 13.42 12.91 7 84630 195 42536503
Myalgia 13.39 12.91 124 84513 95956 42440742
Coronavirus infection 13.35 12.91 31 84606 5183 42531515
Cerebral infarction 13.35 12.91 26 84611 31143 42505555
Subarachnoid haemorrhage 13.34 12.91 6 84631 14466 42522232
Scrotal infection 13.31 12.91 12 84625 831 42535867
Mycobacterium fortuitum infection 13.30 12.91 9 84628 408 42536290
Rectal haemorrhage 13.30 12.91 52 84585 49554 42487144
Oxygen saturation decreased 13.25 12.91 191 84446 64496 42472202
Pulmonary embolism 13.24 12.91 321 84316 119291 42417407
Memory impairment 13.24 12.91 53 84584 50169 42486529
Device malfunction 13.24 12.91 4 84633 12323 42524375
Pruritus 13.22 12.91 280 84357 188491 42348207
Empyema 13.15 12.91 27 84610 4153 42532545
Tremor 13.12 12.91 126 84511 96803 42439895
Shock haemorrhagic 13.10 12.91 8 84629 16234 42520464
Respiratory symptom 13.07 12.91 3 84634 11103 42525595
Lupus myocarditis 13.02 12.91 4 84633 25 42536673
Sepsis 13.01 12.91 299 84338 199035 42337663
Aortoenteric fistula 13.00 12.91 6 84631 127 42536571
Chest pain 12.92 12.91 197 84440 139333 42397365

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug intolerance 4576.39 11.06 8374 638267 398138 109544520
Drug ineffective 4247.74 11.06 18802 627839 1501738 108440920
Synovitis 3806.91 11.06 6200 640441 267892 109674766
Joint swelling 3719.58 11.06 8073 638568 434772 109507886
Contraindicated product administered 3131.30 11.06 5380 641261 242887 109699771
Treatment failure 2861.77 11.06 5508 641133 271726 109670932
Arthropathy 2479.12 11.06 5302 641339 282220 109660438
Therapeutic product effect decreased 2380.86 11.06 4739 641902 239577 109703081
Rheumatoid arthritis 2202.13 11.06 5185 641456 294428 109648230
Systemic lupus erythematosus 2024.64 11.06 4543 642098 249795 109692863
Death 1777.19 11.06 937 645704 697932 109244726
Hand deformity 1711.73 11.06 3879 642762 214627 109728031
Acute kidney injury 1600.43 11.06 862 645779 634568 109308090
Arthralgia 1561.97 11.06 8802 637839 770830 109171828
Pemphigus 1517.58 11.06 3660 642981 210910 109731748
Swelling 1436.52 11.06 4916 641725 346125 109596533
C-reactive protein abnormal 1401.70 11.06 2630 644011 127065 109815593
Musculoskeletal stiffness 1387.47 11.06 4186 642455 275636 109667022
Anti-cyclic citrullinated peptide antibody positive 1377.67 11.06 3188 643453 178796 109763862
Off label use 1373.35 11.06 14073 632568 1486112 108456546
Glossodynia 1352.88 11.06 3579 643062 218425 109724233
Febrile neutropenia 1322.41 11.06 152 646489 316615 109626043
Anaemia 1286.32 11.06 806 645835 546280 109396378
Rheumatoid factor positive 1270.60 11.06 2545 644096 129095 109813563
Abdominal discomfort 1239.86 11.06 5070 641571 388788 109553870
Alopecia 1217.36 11.06 4782 641859 359971 109582687
Hepatic enzyme increased 1185.44 11.06 4346 642295 316546 109626112
Pericarditis 1157.30 11.06 3353 643288 215761 109726897
Pain 1115.93 11.06 9447 637194 945508 108997150
Red blood cell sedimentation rate abnormal 1113.94 11.06 1014 645627 23495 109919163
Peripheral swelling 1073.14 11.06 4942 641699 399092 109543566
Constipation 1017.69 11.06 409 646232 357377 109585281
Wound 1001.18 11.06 3332 643309 231105 109711553
Helicobacter infection 964.80 11.06 2788 643853 179089 109763569
Duodenal ulcer perforation 952.31 11.06 2734 643907 174966 109767692
Drug hypersensitivity 943.25 11.06 5182 641459 448908 109493750
Psoriatic arthropathy 897.14 11.06 2860 643781 193901 109748757
Hypotension 882.43 11.06 1059 645582 522790 109419868
Hypersensitivity 850.60 11.06 4628 642013 399370 109543288
Malignant neoplasm progression 845.47 11.06 42 646599 174525 109768133
Red blood cell sedimentation rate increased 830.92 11.06 1576 645065 76726 109865932
Neutropenia 812.89 11.06 602 646039 374018 109568640
Dehydration 808.71 11.06 311 646330 279200 109663458
Completed suicide 794.16 11.06 217 646424 242164 109700494
Folliculitis 781.65 11.06 2456 644185 165197 109777461
Gastrointestinal disorder 778.89 11.06 3138 643503 238814 109703844
C-reactive protein increased 774.40 11.06 2916 643725 215003 109727655
Muscle injury 759.68 11.06 2172 644469 138635 109804023
Hyponatraemia 751.39 11.06 175 646466 217478 109725180
Impaired healing 747.41 11.06 2690 643951 194027 109748631
Maternal exposure during pregnancy 734.79 11.06 3196 643445 251687 109690971
Irritable bowel syndrome 733.95 11.06 2371 644270 161844 109780814
Infusion related reaction 719.39 11.06 4241 642400 376921 109565737
Sleep disorder due to general medical condition, insomnia type 712.03 11.06 1770 644871 103873 109838785
Toxicity to various agents 711.12 11.06 1068 645573 479487 109463171
Ill-defined disorder 682.31 11.06 2244 644397 154609 109788049
Somnolence 674.07 11.06 456 646185 296993 109645665
Mobility decreased 672.06 11.06 2961 643680 234461 109708197
Fibromyalgia 662.75 11.06 2353 644288 168556 109774102
Osteoarthritis 661.44 11.06 2459 644182 180164 109762494
Discomfort 659.56 11.06 2745 643896 211962 109730696
Drug abuse 648.49 11.06 125 646516 177286 109765372
Inflammation 640.82 11.06 2530 644111 190708 109751950
Condition aggravated 640.50 11.06 6837 639804 727999 109214659
Seizure 628.37 11.06 253 646388 220932 109721726
Thrombocytopenia 621.02 11.06 674 645967 348211 109594447
Lower respiratory tract infection 620.51 11.06 2941 643700 240165 109702493
Infection 570.60 11.06 3849 642792 358351 109584307
Blister 560.19 11.06 2723 643918 224653 109718005
Therapeutic product effect incomplete 546.89 11.06 2674 643967 221131 109721527
Drug interaction 540.74 11.06 1340 645301 498843 109443815
Tremor 523.30 11.06 264 646377 201968 109740690
Rheumatic fever 519.02 11.06 1738 644903 120841 109821817
Loss of personal independence in daily activities 512.54 11.06 1983 644658 148037 109794621
Atrial fibrillation 512.26 11.06 358 646283 229284 109713374
Sinusitis 495.08 11.06 3199 643442 293489 109649169
Arthritis 486.16 11.06 2106 644535 165480 109777178
Disease progression 485.53 11.06 427 646214 243607 109699051
Platelet count decreased 480.87 11.06 385 646256 230058 109712600
Sepsis 480.51 11.06 731 645910 326615 109616043
Gastrointestinal haemorrhage 475.53 11.06 186 646455 165332 109777326
Bone erosion 473.02 11.06 918 645723 45453 109897205
Joint range of motion decreased 472.72 11.06 1678 644963 120154 109822504
Rhabdomyolysis 463.62 11.06 74 646567 120327 109822331
Product use issue 462.73 11.06 3265 643376 308430 109634228
Bradycardia 458.06 11.06 168 646473 155349 109787309
Musculoskeletal pain 457.28 11.06 2201 644440 180822 109761836
Neutrophil count decreased 455.32 11.06 79 646562 120862 109821796
Retinal toxicity 451.63 11.06 212 646429 1447 109941211
Hyperkalaemia 449.52 11.06 119 646522 135677 109806981
Type 2 diabetes mellitus 435.32 11.06 2121 644520 175111 109767547
Stomatitis 427.82 11.06 2876 643765 267366 109675292
Coma 426.59 11.06 85 646556 117784 109824874
Grip strength decreased 415.13 11.06 1219 645422 78955 109863703
Dyspnoea 413.47 11.06 4310 642331 1102562 108840096
Rash 409.89 11.06 6907 639734 814057 109128601
Blood cholesterol increased 404.51 11.06 2141 644500 182644 109760014
Depressed level of consciousness 402.12 11.06 83 646558 112195 109830463
Lactic acidosis 398.58 11.06 40 646601 92771 109849887
Nasopharyngitis 389.91 11.06 3768 642873 390593 109552065
Product dose omission issue 379.70 11.06 822 645819 320960 109621698
Swollen joint count increased 379.04 11.06 1214 645427 82447 109860211
Overdose 372.85 11.06 492 646149 233302 109709356
Syncope 372.82 11.06 380 646261 202156 109740502
Cardiac arrest 364.62 11.06 367 646274 196386 109746272
White blood cell count decreased 363.50 11.06 485 646156 228905 109713753
Pulmonary embolism 361.14 11.06 433 646208 214041 109728617
Cardio-respiratory arrest 358.65 11.06 115 646526 115721 109826937
Cytokine release syndrome 356.81 11.06 12 646629 70294 109872364
Renal failure 353.00 11.06 485 646156 226089 109716569
Knee arthroplasty 351.18 11.06 1003 645638 63945 109878713
Agitation 350.43 11.06 112 646529 112939 109829719
Cerebrovascular accident 348.85 11.06 327 646314 180957 109761701
Liver injury 347.32 11.06 1769 644872 148644 109794014
Rheumatoid nodule 346.57 11.06 506 646135 19790 109922868
Fall 346.16 11.06 2089 644552 601393 109341265
Facet joint syndrome 343.85 11.06 1296 645345 95532 109847126
Lupus nephritis 343.27 11.06 255 646386 4390 109938268
Pulmonary fibrosis 338.82 11.06 1337 645304 100705 109841953
Hallucination 331.71 11.06 91 646550 101341 109841317
Epistaxis 322.77 11.06 180 646461 130192 109812466
Hyperhidrosis 319.75 11.06 374 646267 186924 109755734
Pancytopenia 317.27 11.06 458 646183 209155 109733503
Neoplasm progression 305.02 11.06 18 646623 64577 109878081
Tachycardia 304.53 11.06 536 646105 226109 109716549
Sedation 299.30 11.06 30 646611 69653 109873005
Hip arthroplasty 296.97 11.06 857 645784 54956 109887702
Suicide attempt 293.96 11.06 118 646523 103276 109839382
Intentional product use issue 291.98 11.06 2461 644180 245445 109697213
Dysphagia 284.00 11.06 287 646354 153313 109789345
Sciatica 283.96 11.06 1182 645459 91217 109851441
Hypoxia 282.05 11.06 207 646434 129308 109813350
Night sweats 279.97 11.06 1533 645108 132450 109810208
Lip dry 278.16 11.06 1242 645399 98841 109843817
Cardiac failure 277.07 11.06 417 646224 187209 109755449
Cognitive disorder 272.47 11.06 86 646555 87425 109855233
Urinary tract infection 269.69 11.06 989 645652 325293 109617365
Joint stiffness 267.50 11.06 934 645707 66309 109876349
International normalised ratio increased 267.10 11.06 87 646554 86685 109855973
Pneumonia 266.87 11.06 3569 643072 873145 109069513
Myelosuppression 266.03 11.06 109 646532 94231 109848427
Blood glucose increased 264.43 11.06 231 646410 132265 109810393
Intentional overdose 262.04 11.06 233 646408 132268 109810390
Retinopathy 257.54 11.06 211 646430 4218 109938440
Musculoskeletal disorder 256.36 11.06 469 646172 22195 109920463
Bursitis 255.20 11.06 1462 645179 128456 109814202
Contusion 254.63 11.06 2278 644363 231083 109711575
Plasma cell myeloma 253.11 11.06 34 646607 62902 109879756
Blood creatinine increased 252.54 11.06 425 646216 182464 109760194
Metabolic acidosis 252.30 11.06 134 646507 99610 109843048
Renal impairment 251.02 11.06 448 646193 187997 109754661
Balance disorder 249.04 11.06 190 646451 116370 109826288
Blood bilirubin increased 248.71 11.06 68 646573 75904 109866754
Maculopathy 248.28 11.06 177 646464 2850 109939808
Hepatic function abnormal 245.66 11.06 107 646534 89188 109853470
Adverse event 243.69 11.06 1269 645372 107540 109835118
Foot deformity 242.26 11.06 728 645913 47752 109894906
Hyperglycaemia 242.07 11.06 97 646544 84993 109857665
Ascites 240.22 11.06 121 646520 92687 109849971
Neuropathy peripheral 239.88 11.06 425 646216 178852 109763806
Gait inability 239.26 11.06 1490 645151 134886 109807772
Drug tolerance decreased 239.06 11.06 510 646131 27030 109915628
Pneumonia aspiration 238.74 11.06 88 646553 81145 109861513
Exposure during pregnancy 238.44 11.06 1737 644904 165687 109776971
Melaena 235.74 11.06 56 646585 68701 109873957
Multiple organ dysfunction syndrome 234.99 11.06 326 646315 151384 109791274
Hypoglycaemia 233.42 11.06 201 646440 115903 109826755
Injury 233.20 11.06 1805 644836 175460 109767198
Dysarthria 232.69 11.06 100 646541 84021 109858637
Breast cancer stage III 232.16 11.06 998 645643 78119 109864539
Blood pressure decreased 231.68 11.06 199 646442 114892 109827766
Disorientation 229.96 11.06 64 646577 70607 109872051
Cardiac failure congestive 229.38 11.06 329 646312 150671 109791987
Disability 228.92 11.06 530 646111 29693 109912965
Obesity 228.17 11.06 1284 645357 112067 109830591
Respiratory failure 226.79 11.06 584 646057 214748 109727910
Abdominal pain 226.12 11.06 1915 644726 511074 109431584
Pyrexia 225.99 11.06 3794 642847 894471 109048187
Haemoglobin decreased 222.98 11.06 728 645913 247999 109694659
Multiple sclerosis relapse 222.80 11.06 19 646622 50221 109892437
Sleep disorder 221.78 11.06 1949 644692 196695 109745963
Peripheral venous disease 219.70 11.06 1025 645616 83092 109859566
Urinary retention 219.59 11.06 67 646574 69616 109873042
Acute myocardial infarction 218.68 11.06 108 646533 83669 109858989
Unresponsive to stimuli 218.62 11.06 52 646589 63738 109878920
Blood parathyroid hormone decreased 217.23 11.06 322 646319 12767 109929891
Colitis 215.80 11.06 169 646472 102154 109840504
Restlessness 215.61 11.06 35 646606 56224 109886434
Diarrhoea 215.25 11.06 5050 641591 1134455 108808203
Cerebral haemorrhage 214.85 11.06 57 646584 64911 109877747
Granuloma skin 214.34 11.06 296 646345 10987 109931671
Polyarthritis 213.96 11.06 392 646249 18571 109924087
Encephalopathy 213.84 11.06 103 646538 80952 109861706
Panniculitis 212.21 11.06 350 646291 15232 109927426
Disturbance in attention 211.55 11.06 51 646590 61944 109880714
Vision blurred 209.23 11.06 268 646373 128754 109813904
Respiratory arrest 208.93 11.06 43 646598 58256 109884402
Dyskinesia 208.79 11.06 27 646614 51419 109891239
Serotonin syndrome 207.15 11.06 46 646595 59107 109883551
Impaired work ability 199.78 11.06 463 646178 25956 109916702
Chest discomfort 198.45 11.06 452 646189 173396 109769262
Hypomagnesaemia 197.68 11.06 54 646587 60316 109882342
Haematochezia 196.78 11.06 231 646410 115293 109827365
Palmar-plantar erythrodysaesthesia syndrome 195.02 11.06 11 646630 41014 109901644
Tubulointerstitial nephritis 194.62 11.06 40 646601 54244 109888414
Deep vein thrombosis postoperative 193.66 11.06 773 645868 58518 109884140
Myalgia 193.07 11.06 660 645981 221721 109720937
Pulmonary oedema 190.75 11.06 184 646457 100475 109842183
Cough 189.43 11.06 1755 644886 459886 109482772
Weight increased 188.43 11.06 3474 643167 416170 109526488
Jaundice 188.39 11.06 56 646585 59180 109883478
Palpitations 188.24 11.06 406 646235 158806 109783852
Haemorrhage 187.52 11.06 208 646433 106484 109836174
Aggression 186.45 11.06 57 646584 59153 109883505
Wound infection 186.44 11.06 1081 645560 95384 109847274
Pleural effusion 186.32 11.06 483 646158 177226 109765432
Orthostatic hypotension 186.05 11.06 77 646564 66172 109876486
Dry skin 184.72 11.06 214 646427 107439 109835219
Wrong technique in product usage process 183.27 11.06 145 646496 87203 109855455
Sopor 182.80 11.06 7 646634 36539 109906119
Deformity 181.79 11.06 259 646382 9901 109932757
Intentional product misuse 180.56 11.06 312 646329 132592 109810066
Mucosal inflammation 179.57 11.06 178 646463 95963 109846695
Altered state of consciousness 178.73 11.06 57 646584 57569 109885089
Osteoporosis 178.55 11.06 992 645649 86160 109856498
Hepatic failure 177.33 11.06 90 646551 68649 109874009
Onychomadesis 176.22 11.06 628 646013 45035 109897623
Loss of consciousness 175.62 11.06 575 646066 195731 109746927
Autoimmune disorder 171.77 11.06 799 645842 64684 109877974
X-ray abnormal 171.58 11.06 552 646089 37565 109905093
Joint effusion 169.90 11.06 377 646264 20528 109922130
Chills 169.27 11.06 560 646081 190020 109752638
Coronary artery disease 168.91 11.06 105 646536 71585 109871073
Bone marrow failure 166.10 11.06 65 646576 57783 109884875
Angioedema 165.58 11.06 199 646442 98301 109844357
Therapeutic response decreased 165.29 11.06 1048 645593 95451 109847207
Vomiting 164.76 11.06 4061 642580 906614 109036044
Finger deformity 164.46 11.06 496 646145 32596 109910062
Blood urea increased 164.10 11.06 58 646583 54899 109887759
Lethargy 163.83 11.06 183 646458 93393 109849265
Upper gastrointestinal haemorrhage 163.67 11.06 45 646596 50051 109892607
Myocardial infarction 162.74 11.06 576 646065 191507 109751151
Herpes zoster 162.71 11.06 1139 645502 107240 109835418
Live birth 162.26 11.06 820 645821 68664 109873994
Nodule 162.08 11.06 489 646152 32142 109910516
Tumour lysis syndrome 160.90 11.06 4 646637 30797 109911861
Hypophosphataemia 160.54 11.06 8 646633 33174 109909484
Dislocation of vertebra 160.00 11.06 591 646050 43130 109899528
Anxiety 159.75 11.06 1271 645370 343807 109598851
Generalised tonic-clonic seizure 159.39 11.06 60 646581 54620 109888038
Accidental overdose 157.72 11.06 53 646588 51781 109890877
Mental status changes 157.66 11.06 128 646513 75994 109866664
Incorrect dose administered 156.22 11.06 227 646414 103414 109839244
Tenosynovitis 155.95 11.06 314 646327 15969 109926689
Therapy non-responder 155.62 11.06 1504 645137 155803 109786855
Respiratory distress 155.30 11.06 106 646535 68768 109873890
Haematemesis 154.57 11.06 76 646565 59032 109883626
Swollen tongue 154.26 11.06 80 646561 60282 109882376
Suicidal ideation 153.47 11.06 194 646447 93743 109848915
Full blood count abnormal 152.86 11.06 68 646573 55984 109886674
Abnormal behaviour 152.52 11.06 23 646618 39016 109903642
Irritability 152.40 11.06 45 646596 47764 109894894
Nail disorder 151.30 11.06 706 645935 57229 109885429
Haematuria 150.11 11.06 158 646483 82847 109859811
Neurotoxicity 149.46 11.06 32 646609 42175 109900483
Joint destruction 149.29 11.06 246 646395 10697 109931961
Onychomycosis 148.76 11.06 530 646111 38001 109904657
Aphasia 148.11 11.06 80 646561 58917 109883741
Neuroleptic malignant syndrome 148.01 11.06 14 646627 34045 109908613
Skin exfoliation 147.42 11.06 177 646464 87474 109855184
Chronic obstructive pulmonary disease 146.69 11.06 258 646383 108900 109833758
Deep vein thrombosis 145.25 11.06 382 646259 139505 109803153
Drug withdrawal syndrome 145.10 11.06 24 646617 38030 109904628
Diabetic ketoacidosis 144.68 11.06 34 646607 42024 109900634
Dysgeusia 144.54 11.06 118 646523 69867 109872791
Metastases to bone 144.37 11.06 10 646631 31362 109911296
Pain in extremity 143.60 11.06 3797 642844 483321 109459337
Circulatory collapse 143.53 11.06 37 646604 42956 109899702
Blood calcium decreased 142.63 11.06 20 646621 35825 109906833
Rheumatoid factor negative 142.52 11.06 91 646550 1209 109941449
Liver function test increased 142.09 11.06 946 645695 87602 109855056
Hypokalaemia 141.62 11.06 567 646074 181881 109760777
Osteonecrosis of jaw 141.12 11.06 52 646589 47965 109894693
Blood alkaline phosphatase increased 139.91 11.06 125 646516 70810 109871848
Apparent death 139.60 11.06 124 646517 2778 109939880
Vertigo 139.23 11.06 182 646459 86688 109855970
Lower limb fracture 138.91 11.06 834 645807 74514 109868144
Hepatic cytolysis 137.70 11.06 75 646566 54978 109887680
Lymphocyte count decreased 137.43 11.06 82 646559 57161 109885497
Dizziness 136.25 11.06 3077 643564 695116 109247542
Haemoptysis 135.70 11.06 130 646511 71224 109871434
Bone pain 135.54 11.06 109 646532 65024 109877634
Dysuria 135.40 11.06 93 646548 60138 109882520
Seronegative arthritis 134.52 11.06 261 646380 12916 109929742
Hypercholesterolaemia 133.64 11.06 950 645691 89887 109852771
Tuberculin test positive 132.98 11.06 134 646507 3534 109939124
Obstructive airways disorder 132.26 11.06 52 646589 46097 109896561
Poisoning deliberate 131.84 11.06 5 646636 26326 109916332
Urticaria 131.84 11.06 2607 644034 316250 109626408
Intentional self-injury 131.27 11.06 29 646612 37400 109905258
Metastases to liver 131.23 11.06 24 646617 35362 109907296
Cardiogenic shock 130.95 11.06 87 646554 57251 109885407
Fine motor skill dysfunction 130.46 11.06 172 646469 6102 109936556
Decreased appetite 129.95 11.06 1978 644663 473868 109468790
Status epilepticus 129.50 11.06 16 646625 31555 109911103
Lupus-like syndrome 129.36 11.06 527 646114 40265 109902393
Septic shock 129.05 11.06 479 646162 157049 109785609
Blood creatine phosphokinase increased 128.93 11.06 142 646499 72935 109869723
Transient ischaemic attack 128.30 11.06 111 646530 63871 109878787
Cholestasis 128.08 11.06 113 646528 64405 109878253
Haematoma 127.89 11.06 93 646548 58383 109884275
Cerebral infarction 127.66 11.06 72 646569 51766 109890892
Inappropriate schedule of product administration 126.63 11.06 686 645955 202951 109739707
Liver disorder 126.26 11.06 1330 645311 140913 109801745
Road traffic accident 126.21 11.06 1066 645575 106332 109836326
Rheumatoid lung 125.44 11.06 140 646501 4164 109938494
Adverse drug reaction 125.25 11.06 1050 645591 104509 109838149
Chronic kidney disease 125.20 11.06 157 646484 76134 109866524
Acute myeloid leukaemia 124.94 11.06 34 646607 38076 109904582
Hyperthyroidism 124.61 11.06 13 646628 29248 109913410
Pallor 124.54 11.06 89 646552 56378 109886280
Adjustment disorder with depressed mood 124.47 11.06 548 646093 43335 109899323
Device expulsion 123.47 11.06 17 646624 30874 109911784
Hallucination, visual 121.37 11.06 40 646601 39565 109903093
C-reactive protein 121.22 11.06 422 646219 29909 109912749
Oedema peripheral 120.69 11.06 1283 645358 327377 109615281
Subdural haematoma 120.50 11.06 32 646609 36422 109906236
Angina pectoris 120.22 11.06 112 646529 62183 109880475
Hepatitis 119.49 11.06 919 645722 89135 109853523
Anti-cyclic citrullinated peptide antibody 119.46 11.06 320 646321 19644 109923014
Inappropriate antidiuretic hormone secretion 119.18 11.06 26 646615 33825 109908833
Bone density decreased 118.95 11.06 279 646362 15763 109926895
Elbow deformity 118.59 11.06 86 646555 1424 109941234
Accidental exposure to product 118.14 11.06 73 646568 49935 109892723
Flatulence 117.92 11.06 80 646561 52069 109890589
Dyspnoea exertional 117.55 11.06 272 646369 103788 109838870
Extrapyramidal disorder 117.50 11.06 15 646626 28852 109913806
Muscle twitching 116.11 11.06 18 646623 29917 109912741
SLE arthritis 116.08 11.06 62 646579 575 109942083
Troponin increased 115.23 11.06 18 646623 29748 109912910
Tachypnoea 115.21 11.06 43 646598 39352 109903306
Hypothyroidism 114.51 11.06 155 646486 72744 109869914
Cytomegalovirus infection 113.43 11.06 91 646550 54353 109888305
Nightmare 112.68 11.06 43 646598 38820 109903838
Lung disorder 112.44 11.06 1575 645066 178472 109764186
Rectal haemorrhage 112.06 11.06 344 646297 119489 109823169
Clostridium difficile colitis 111.90 11.06 58 646583 43720 109898938
Blood lactate dehydrogenase increased 111.46 11.06 60 646581 44274 109898384
Withdrawal syndrome 110.69 11.06 24 646617 31356 109911302
Coordination abnormal 110.62 11.06 10 646631 25218 109917440
Schizophrenia 109.78 11.06 4 646637 21822 109920836
Intestinal obstruction 109.60 11.06 90 646551 53137 109889521
Ischaemic stroke 109.50 11.06 52 646589 41211 109901447
Injection site pain 109.17 11.06 602 646039 177320 109765338
Adverse reaction 109.09 11.06 401 646240 29193 109913465
Small intestinal obstruction 108.93 11.06 27 646614 32186 109910472
Cholelithiasis 108.87 11.06 126 646515 63296 109879362
Emotional distress 108.00 11.06 64 646577 44783 109897875
Miosis 107.32 11.06 5 646636 21978 109920680
Electrolyte imbalance 107.31 11.06 41 646600 36987 109905671
Joint laxity 106.68 11.06 100 646541 2407 109940251
Flushing 106.46 11.06 289 646352 104447 109838211
Renal phospholipidosis 105.70 11.06 50 646591 348 109942310
Retinitis 104.39 11.06 420 646221 31907 109910751
Pancreatitis acute 104.27 11.06 119 646522 60155 109882503
Gamma-glutamyltransferase increased 103.96 11.06 123 646518 61186 109881472
Wrist deformity 103.88 11.06 110 646531 3079 109939579
Cardiac disorder 103.66 11.06 179 646462 76101 109866557
Nausea 103.59 11.06 6043 640598 1229647 108713011
Joint injury 103.42 11.06 486 646155 39508 109903150
Human antichimeric antibody positive 103.42 11.06 84 646557 1658 109941000
Exostosis 102.87 11.06 536 646105 45420 109897238
Acute respiratory failure 102.82 11.06 176 646465 75084 109867574
Asthenia 102.80 11.06 3156 643485 685843 109256815
Presyncope 102.74 11.06 81 646560 48806 109893852
Hypervolaemia 102.63 11.06 83 646558 49377 109893281
Hemiparesis 102.46 11.06 65 646576 43838 109898820
Subarachnoid haemorrhage 102.19 11.06 24 646617 29678 109912980
Product administration error 101.72 11.06 45 646596 37172 109905486
Device related infection 101.54 11.06 52 646589 39467 109903191
Long QT syndrome 101.15 11.06 163 646478 6955 109935703
Erythema 100.91 11.06 1153 645488 290294 109652364
Myoclonus 99.94 11.06 34 646607 32964 109909694
Swelling face 99.77 11.06 247 646394 92074 109850584
Full blood count decreased 99.10 11.06 32 646609 32067 109910591
Neck pain 99.01 11.06 1129 645512 122001 109820657
Device dislocation 98.96 11.06 31 646610 31673 109910985
Skin necrosis 97.24 11.06 312 646329 21200 109921458
Eczema 96.10 11.06 172 646469 72121 109870537
Shoulder arthroplasty 96.10 11.06 112 646529 3495 109939163
Fluid retention 96.02 11.06 260 646381 94047 109848611
Shock haemorrhagic 95.78 11.06 21 646620 27226 109915432
Oral mucosal exfoliation 95.25 11.06 78 646563 1558 109941100
Hypothermia 95.08 11.06 19 646622 26283 109916375
Arrhythmia 94.78 11.06 163 646478 69412 109873246
Bone cyst 94.53 11.06 111 646530 3492 109939166
Ileus 94.22 11.06 31 646610 30698 109911960
Spinal stenosis 94.10 11.06 285 646356 18771 109923887
Blood potassium decreased 93.44 11.06 107 646534 54007 109888651
Ventricular fibrillation 92.58 11.06 64 646577 41249 109901409
Musculoskeletal deformity 92.43 11.06 75 646566 1478 109941180
Body height below normal 92.29 11.06 85 646556 1999 109940659
Back injury 92.11 11.06 532 646109 46867 109895791
Dementia 91.90 11.06 35 646606 31638 109911020
Poisoning 91.67 11.06 28 646613 29077 109913581
Blepharospasm 91.63 11.06 592 646049 54259 109888399
Parkinsonism 91.60 11.06 11 646630 22176 109920482
Pemphigoid 91.51 11.06 6 646635 19701 109922957
Shock 91.41 11.06 107 646534 53481 109889177
Aplastic anaemia 91.20 11.06 16 646625 24292 109918366
Prescribed underdose 90.90 11.06 673 645968 64501 109878157
Dry mouth 90.89 11.06 1659 644982 198289 109744369
Urinary incontinence 90.67 11.06 90 646551 48497 109894161
Paranoia 90.17 11.06 12 646629 22362 109920296
Psychotic disorder 89.83 11.06 99 646542 50838 109891820
Glaucoma 89.73 11.06 313 646328 22204 109920454
Neutropenic sepsis 89.17 11.06 34 646607 30712 109911946
Leukocytosis 89.14 11.06 110 646531 53718 109888940
Diverticulitis 89.01 11.06 577 646064 52945 109889713
Hypophagia 88.78 11.06 106 646535 52520 109890138
Disseminated intravascular coagulation 88.55 11.06 67 646574 41219 109901439
Erectile dysfunction 88.12 11.06 5 646636 18551 109924107
Blood sodium decreased 87.70 11.06 58 646583 38261 109904397
Gastritis 87.60 11.06 111 646530 53588 109889070
Hepatocellular injury 87.59 11.06 100 646541 50542 109892116
Electrocardiogram QT prolonged 87.57 11.06 999 645642 107961 109834697
Feeling abnormal 87.11 11.06 658 645983 180053 109762605
Ear pain 86.80 11.06 571 646070 52655 109890003
Akathisia 86.55 11.06 3 646638 17110 109925548
Haemorrhage intracranial 85.76 11.06 31 646610 28938 109913720
Premature delivery 85.72 11.06 381 646260 30251 109912407
Aspartate aminotransferase increased 85.58 11.06 565 646076 159371 109783287
Activated partial thromboplastin time prolonged 85.52 11.06 14 646627 22354 109920304
Glycosylated haemoglobin increased 85.51 11.06 17 646624 23602 109919056
Malnutrition 84.56 11.06 27 646614 27252 109915406
Coagulopathy 84.45 11.06 69 646572 40842 109901816
Cyanosis 84.43 11.06 34 646607 29707 109912951
Myocardial ischaemia 83.45 11.06 26 646615 26658 109916000
Haematotoxicity 83.33 11.06 12 646629 21070 109921588
Depressed mood 83.26 11.06 142 646499 60667 109881991
Agranulocytosis 82.94 11.06 146 646495 61614 109881044
Drug resistance 82.49 11.06 126 646515 56248 109886410
Second primary malignancy 82.45 11.06 6 646635 18062 109924596
Pneumonitis 81.73 11.06 206 646435 76325 109866333
Eye pruritus 81.46 11.06 45 646596 32730 109909928
Lupus vulgaris 81.31 11.06 403 646238 33480 109909178
Graft versus host disease 81.01 11.06 8 646633 18798 109923860
Dystonia 80.96 11.06 25 646616 25780 109916878
Hypoalbuminaemia 80.83 11.06 34 646607 28940 109913718
COVID-19 80.76 11.06 980 645661 244080 109698578
Clostridium difficile infection 80.71 11.06 112 646529 52017 109890641
Anaphylactic shock 80.55 11.06 110 646531 51436 109891222
Speech disorder 80.48 11.06 148 646493 61421 109881237
Red blood cell sedimentation rate 80.46 11.06 124 646517 5090 109937568
Therapy interrupted 80.22 11.06 104 646537 49718 109892940
Surgical failure 79.81 11.06 56 646585 878 109941780
Back pain 79.19 11.06 1611 645030 369385 109573273
Loose body in joint 79.13 11.06 66 646575 1354 109941304
Blood triglycerides increased 79.09 11.06 21 646620 23905 109918753
Hyperphosphataemia 79.09 11.06 4 646637 16377 109926281
Proctitis 79.06 11.06 5 646636 16922 109925736
Maternal exposure timing unspecified 78.53 11.06 286 646355 20727 109921931
Appendicitis 78.45 11.06 34 646607 28430 109914228
Ataxia 78.28 11.06 39 646602 30069 109912589
Physical disability 78.19 11.06 121 646520 4985 109937673
Drug tolerance 78.13 11.06 244 646397 16341 109926317
Device issue 78.06 11.06 53 646588 34482 109908176
Cellulitis 78.05 11.06 425 646216 125591 109817067
Pregnancy 77.98 11.06 539 646102 50528 109892130
Sinus tachycardia 77.89 11.06 87 646554 44406 109898252
Muscle rigidity 77.73 11.06 22 646619 24009 109918649
Pulmonary congestion 77.71 11.06 42 646599 30924 109911734
Injection site reaction 77.23 11.06 829 645812 88241 109854417
Paraesthesia oral 77.01 11.06 51 646590 33620 109909038
Head injury 76.53 11.06 83 646558 42934 109899724
Drug level increased 76.44 11.06 100 646541 47619 109895039
Transfusion 75.84 11.06 27 646614 25445 109917213
Blood phosphorus increased 75.80 11.06 5 646636 16335 109926323
Venoocclusive liver disease 75.76 11.06 3 646638 15204 109927454
Metastases to central nervous system 75.47 11.06 20 646621 22797 109919861
Prescribed overdose 75.41 11.06 814 645827 86767 109855891
Bacteraemia 75.18 11.06 82 646559 42308 109900350
Joint arthroplasty 75.15 11.06 98 646543 3439 109939219
Arteriosclerosis coronary artery 74.15 11.06 27 646614 25091 109917567
Hypovolaemia 73.61 11.06 18 646623 21656 109921002
Mental disorder 73.37 11.06 71 646570 38720 109903938
Aspiration 72.92 11.06 44 646597 30489 109912169
Neutrophil count increased 72.08 11.06 58 646583 34594 109908064
Labelled drug-drug interaction medication error 71.72 11.06 41 646600 29261 109913397
Hemiplegia 71.60 11.06 22 646619 22760 109919898
Wheelchair user 71.28 11.06 148 646493 7694 109934964
Skin ulcer 71.24 11.06 625 646016 63020 109879638
Thrombotic microangiopathy 71.04 11.06 41 646600 29108 109913550
Salivary hypersecretion 71.03 11.06 9 646632 17412 109925246
Hypersomnia 70.51 11.06 38 646603 28023 109914635
Brain oedema 69.92 11.06 48 646593 31050 109911608
Polyneuropathy 69.88 11.06 51 646590 31961 109910697
Hypoaesthesia 69.88 11.06 2366 644275 311857 109630801
Ulcer 69.37 11.06 461 646180 42655 109900003
Ejection fraction decreased 69.32 11.06 82 646559 40798 109901860
Dialysis 69.21 11.06 15 646626 19604 109923054
Jaundice cholestatic 69.18 11.06 4 646637 14604 109928054
End stage renal disease 68.83 11.06 20 646621 21453 109921205
Blood pressure systolic abnormal 68.72 11.06 308 646333 24542 109918116
Abdominal pain lower 68.50 11.06 70 646571 37213 109905445
Hepatic encephalopathy 68.50 11.06 40 646601 28216 109914442
Arthrodesis 68.45 11.06 82 646559 2636 109940022
Blood glucose decreased 68.34 11.06 44 646597 29444 109913214
Anger 68.14 11.06 14 646627 18993 109923665
Laryngitis 67.96 11.06 453 646188 41958 109900700
Metastases to lung 67.73 11.06 25 646616 23038 109919620
Rash erythematous 67.54 11.06 248 646393 81584 109861074
Intestinal sepsis 67.30 11.06 52 646589 952 109941706
Weight decreased 67.27 11.06 2154 644487 465903 109476755
Toxic encephalopathy 66.79 11.06 6 646635 15208 109927450
Transplant rejection 66.67 11.06 30 646611 24537 109918121
Joint dislocation 66.60 11.06 384 646257 33806 109908852
Urine output decreased 66.55 11.06 17 646624 19859 109922799
Abdominal pain upper 66.47 11.06 2583 644058 346528 109596130
Bloody discharge 66.45 11.06 81 646560 2652 109940006
Drug effective for unapproved indication 66.35 11.06 208 646433 13959 109928699
Acute coronary syndrome 66.30 11.06 26 646615 23086 109919572
Bronchospasm 66.24 11.06 48 646593 30191 109912467
Arteriosclerosis 66.04 11.06 31 646610 24736 109917922
Blood iron abnormal 65.94 11.06 61 646580 1443 109941215
International normalised ratio fluctuation 65.74 11.06 99 646542 3981 109938677
Epicondylitis 65.73 11.06 78 646563 2482 109940176
Product label confusion 65.69 11.06 285 646356 22392 109920266
Prostate cancer 65.45 11.06 74 646567 37567 109905091
Faecaloma 65.12 11.06 6 646635 14902 109927756
Mydriasis 65.10 11.06 24 646617 22133 109920525
Toxic epidermal necrolysis 65.10 11.06 147 646494 56580 109886078
Investigation abnormal 65.00 11.06 76 646565 2380 109940278
Diplopia 64.87 11.06 90 646551 41804 109900854
Bladder cancer 64.86 11.06 19 646622 20273 109922385
Myelodysplastic syndrome 64.84 11.06 74 646567 37410 109905248
Skin haemorrhage 64.79 11.06 32 646609 24795 109917863
Nasal polyps 64.45 11.06 3 646638 13197 109929461
Asphyxia 64.07 11.06 5 646636 14210 109928448
Therapy cessation 63.97 11.06 102 646539 44755 109897903
Blood uric acid increased 63.80 11.06 23 646618 21506 109921152
Drug level decreased 63.79 11.06 15 646626 18533 109924125
Stevens-Johnson syndrome 63.77 11.06 110 646531 46791 109895867
Polyuria 63.73 11.06 13 646628 17725 109924933
Tenderness 63.59 11.06 340 646301 29097 109913561
Pollakiuria 63.50 11.06 100 646541 44095 109898563
Lower gastrointestinal haemorrhage 63.48 11.06 15 646626 18471 109924187
Chronic sinusitis 62.98 11.06 34 646607 25050 109917608
Cholangitis 62.95 11.06 10 646631 16325 109926333
Vaginal discharge 62.55 11.06 14 646627 17894 109924764
Multiple fractures 62.52 11.06 152 646489 8788 109933870
COVID-19 treatment 62.46 11.06 37 646604 426 109942232
Lipase increased 62.46 11.06 16 646625 18656 109924002
Personality disorder 62.41 11.06 3 646638 12834 109929824
Infusion site reaction 62.18 11.06 236 646405 17446 109925212
Glomerular filtration rate decreased 62.09 11.06 47 646594 28909 109913749
Lip swelling 61.71 11.06 127 646514 50540 109892118
Butterfly rash 61.56 11.06 69 646572 2062 109940596
Acute hepatic failure 60.94 11.06 74 646567 36394 109906264
Anal incontinence 60.91 11.06 26 646615 21938 109920720
Alanine aminotransferase increased 60.50 11.06 735 645906 183038 109759620
Diabetes mellitus inadequate control 60.50 11.06 51 646590 29724 109912934
Hospitalisation 60.37 11.06 537 646104 141956 109800702
Coeliac disease 60.24 11.06 446 646195 42741 109899917
Lyme disease 60.19 11.06 98 646543 4218 109938440
Antiphospholipid syndrome 60.09 11.06 74 646567 2449 109940209
Respiratory disorder 59.86 11.06 660 645981 70722 109871936
Procedural pain 59.60 11.06 72 646569 35493 109907165
Central nervous system lupus 59.56 11.06 55 646586 1298 109941360
Pathogen resistance 59.39 11.06 15 646626 17657 109925001
Deafness transitory 59.25 11.06 50 646591 1043 109941615
Post transplant lymphoproliferative disorder 59.18 11.06 10 646631 15603 109927055
Eye disorder 59.17 11.06 329 646312 28577 109914081
Face oedema 59.07 11.06 65 646576 33404 109909254
Haemorrhagic stroke 59.04 11.06 6 646635 13783 109928875
Hallucination, auditory 59.01 11.06 41 646600 26356 109916302
Haemodynamic instability 58.98 11.06 30 646611 22858 109919800
Hepatic enzyme abnormal 58.93 11.06 157 646484 9606 109933052
Pericardial effusion 58.80 11.06 157 646484 57060 109885598
Eosinophilia 58.77 11.06 160 646481 57776 109884882
Hyperammonaemia 58.74 11.06 6 646635 13726 109928932
Synovial cyst 58.38 11.06 173 646468 11257 109931401
Micturition urgency 58.35 11.06 20 646621 19300 109923358
Enterocolitis 58.30 11.06 19 646622 18930 109923728
Anuria 58.24 11.06 35 646606 24306 109918352
Acute pulmonary oedema 57.95 11.06 14 646627 16982 109925676
Haemodialysis 57.73 11.06 16 646625 17703 109924955
Hypertensive crisis 56.99 11.06 36 646605 24336 109918322
Faeces discoloured 56.60 11.06 69 646572 33879 109908779
Petechiae 56.53 11.06 33 646608 23284 109919374
Temperature regulation disorder 56.46 11.06 5 646636 12821 109929837
Mental impairment 56.38 11.06 31 646610 22608 109920050
Duodenal ulcer 55.90 11.06 22 646619 19492 109923166
Abdominal distension 55.88 11.06 705 645936 174398 109768260
Device difficult to use 55.88 11.06 20 646621 18785 109923873
Tuberculosis 55.86 11.06 229 646412 17545 109925113
Female genital tract fistula 55.56 11.06 14 646627 16505 109926153
Fatigue 55.34 11.06 8010 638631 1207948 108734710
Terminal state 55.13 11.06 110 646531 5557 109937101
Pustular psoriasis 54.98 11.06 190 646451 13415 109929243
Colitis microscopic 54.95 11.06 188 646453 13206 109929452
Benign prostatic hyperplasia 54.85 11.06 19 646622 18215 109924443
Influenza like illness 54.84 11.06 298 646343 88114 109854544
Infective pulmonary exacerbation of cystic fibrosis 54.81 11.06 10 646631 14761 109927897
Enthesopathy 54.61 11.06 179 646462 12299 109930359
Gastric disorder 54.48 11.06 358 646283 32999 109909659
Cholecystitis 54.24 11.06 43 646598 25839 109916819
Gout 54.20 11.06 81 646560 36485 109906173
Mania 53.97 11.06 27 646614 20769 109921889
Blood calcium increased 53.92 11.06 19 646622 18021 109924637
Heart rate increased 53.75 11.06 559 646082 143275 109799383
Walking aid user 53.75 11.06 289 646352 24786 109917872
Retching 53.73 11.06 33 646608 22649 109920009
Thirst 53.66 11.06 30 646611 21677 109920981
Hyperuricaemia 53.57 11.06 10 646631 14521 109928137
Pulmonary hypertension 53.43 11.06 156 646485 55064 109887594
Sensitivity to weather change 53.35 11.06 154 646487 9874 109932784
Acquired pigmented retinopathy 53.11 11.06 14 646627 6 109942652
Sleep apnoea syndrome 53.07 11.06 97 646544 40350 109902308
Thyroid neoplasm 53.05 11.06 80 646561 3221 109939437
Delusion 52.96 11.06 37 646604 23718 109918940
Bone swelling 52.67 11.06 59 646582 1762 109940896
Myocarditis 52.35 11.06 59 646582 29996 109912662
Blood pressure diastolic abnormal 52.29 11.06 293 646348 25522 109917136
Bone density abnormal 52.25 11.06 87 646554 3816 109938842
Eye swelling 52.17 11.06 70 646571 32978 109909680
Sudden death 51.79 11.06 40 646601 24355 109918303
Anticipatory anxiety 51.34 11.06 49 646592 1207 109941451
Device leakage 51.34 11.06 15 646626 16033 109926625
Toxic skin eruption 51.30 11.06 51 646590 27464 109915194
Adjustment disorder 50.98 11.06 3 646638 10792 109931866
Colitis ischaemic 50.86 11.06 20 646621 17730 109924928
Foot operation 50.78 11.06 124 646517 7189 109935469
Chest pain 50.76 11.06 1746 644895 374629 109568029
Feeling cold 50.66 11.06 75 646566 33912 109908746
Presbyacusis 50.64 11.06 72 646569 2747 109939911
Incontinence 50.62 11.06 17 646624 16618 109926040
Cystitis haemorrhagic 50.53 11.06 6 646635 12203 109930455
Device malfunction 50.44 11.06 45 646596 25513 109917145
Acidosis 50.36 11.06 35 646606 22496 109920162
Ear infection 50.32 11.06 575 646066 62157 109880501
Hyperthermia 50.32 11.06 31 646610 21241 109921417
Oliguria 50.29 11.06 23 646618 18634 109924024
Sinus bradycardia 50.14 11.06 59 646582 29424 109913234
Metastases to lymph nodes 50.05 11.06 13 646628 15019 109927639
Prostatic specific antigen increased 49.73 11.06 7 646634 12504 109930154
Renal tubular necrosis 49.70 11.06 63 646578 30412 109912246
Enteritis 49.52 11.06 25 646616 19131 109923527
Ovarian neoplasm 49.44 11.06 36 646605 600 109942058
Hyperbilirubinaemia 49.41 11.06 64 646577 30607 109912051
Oesophageal carcinoma 49.38 11.06 5 646636 11519 109931139
Suspected suicide 49.00 11.06 14 646627 15185 109927473
Proctalgia 48.96 11.06 9 646632 13213 109929445
Failure to thrive 48.66 11.06 10 646631 13564 109929094
Hypopnoea 48.60 11.06 5 646636 11375 109931283
Prothrombin time prolonged 48.56 11.06 20 646621 17241 109925417
Alanine aminotransferase abnormal 48.36 11.06 142 646499 9192 109933466
Gastric ulcer 48.36 11.06 100 646541 39727 109902931
Basal cell carcinoma 48.32 11.06 440 646201 44830 109897828
Hypocalcaemia 48.29 11.06 207 646434 65159 109877499
Needle issue 48.08 11.06 22 646619 17818 109924840
Mood altered 48.05 11.06 33 646608 21342 109921316
Gingival pain 48.03 11.06 16 646625 15720 109926938
Eosinophil count increased 48.02 11.06 32 646609 21026 109921632
Eosinophilic granulomatosis with polyangiitis 47.49 11.06 4 646637 10682 109931976
Neck mass 47.40 11.06 94 646547 4727 109937931
Hepatic cirrhosis 47.32 11.06 604 646037 67022 109875636
Gastric haemorrhage 47.16 11.06 17 646624 15898 109926760
Exposure to toxic agent 47.08 11.06 9 646632 12849 109929809
Panic attack 47.02 11.06 60 646581 28880 109913778
Viral upper respiratory tract infection 47.00 11.06 149 646492 10059 109932599
Drug ineffective for unapproved indication 46.96 11.06 854 645787 101984 109840674
Vascular device infection 46.67 11.06 19 646622 16493 109926165
Anhedonia 46.54 11.06 16 646625 15412 109927246
Hypoacusis 46.52 11.06 84 646557 35107 109907551
Complication associated with device 46.45 11.06 30 646611 20043 109922615
Oesophagitis 46.17 11.06 60 646581 28655 109914003
Renal injury 46.06 11.06 26 646615 18687 109923971
Neck deformity 46.03 11.06 56 646585 1830 109940828
Drug eruption 45.85 11.06 498 646143 53161 109889497
Sensory loss 45.79 11.06 35 646606 21422 109921236
Mesenteritis 45.65 11.06 28 646613 345 109942313
Hypertension 45.64 11.06 3518 643123 506566 109436092
Lacrimation increased 45.45 11.06 69 646572 30881 109911777
Rhinitis allergic 45.42 11.06 24 646617 17898 109924760
Device occlusion 45.38 11.06 16 646625 15169 109927489
Nervous system disorder 45.36 11.06 72 646569 31649 109911009
Heart rate irregular 45.14 11.06 82 646559 34192 109908466
Cholecystitis acute 44.87 11.06 18 646623 15764 109926894
Pulseless electrical activity 44.64 11.06 21 646620 16736 109925922
Dysphonia 44.35 11.06 261 646380 75668 109866990
Ketoacidosis 44.22 11.06 4 646637 10083 109932575
Rash papular 44.18 11.06 58 646583 27581 109915077
Subacute cutaneous lupus erythematosus 43.94 11.06 93 646548 4901 109937757
Coronary artery stenosis 43.76 11.06 13 646628 13745 109928913
Productive cough 43.63 11.06 442 646199 113863 109828795
Lupus vasculitis 43.60 11.06 33 646608 585 109942073
Chronic graft versus host disease 43.56 11.06 3 646638 9454 109933204
Dermatitis atopic 43.56 11.06 51 646590 25490 109917168
Urosepsis 43.51 11.06 70 646571 30605 109912053
Sneezing 43.50 11.06 75 646566 31909 109910749
Eyelid ptosis 43.48 11.06 12 646629 13315 109929343
Ileus paralytic 43.44 11.06 8 646633 11729 109930929
Product prescribing error 43.40 11.06 154 646487 51177 109891481
Psychomotor hyperactivity 43.37 11.06 33 646608 20244 109922414
Tinnitus 43.34 11.06 194 646447 60346 109882312
Neoplasm malignant 43.26 11.06 368 646273 36775 109905883
Bacterial infection 43.14 11.06 132 646509 45904 109896754
Hospice care 43.07 11.06 10 646631 12463 109930195
Rhinitis 42.95 11.06 41 646600 22504 109920154
Dyspepsia 42.95 11.06 1440 645201 189525 109753133
Haemorrhoids 42.95 11.06 90 646551 35582 109907076
Oxygen saturation decreased 42.95 11.06 652 645989 156330 109786328
Juvenile idiopathic arthritis 42.94 11.06 103 646538 5904 109936754
Thrombosis 42.80 11.06 417 646224 108245 109834413
Arterial occlusive disease 42.64 11.06 18 646623 15290 109927368
Neuralgia 42.63 11.06 143 646498 48335 109894323
Pneumocystis jirovecii pneumonia 42.61 11.06 119 646522 42616 109900042
Pancreatitis 42.53 11.06 346 646295 93187 109849471
Blood potassium increased 42.51 11.06 81 646560 33168 109909490
Hydronephrosis 42.47 11.06 35 646606 20630 109922028
Granulocytopenia 42.33 11.06 11 646630 12704 109929954
Serositis 42.27 11.06 49 646592 1520 109941138
Limb discomfort 42.05 11.06 394 646247 40460 109902198
Post procedural haemorrhage 42.01 11.06 19 646622 15493 109927165
Food allergy 41.98 11.06 33 646608 19915 109922743
Ageusia 41.98 11.06 32 646609 19613 109923045
Cutaneous lupus erythematosus 41.77 11.06 74 646567 3414 109939244
Large intestine polyp 41.75 11.06 18 646623 15099 109927559
Skin toxicity 41.58 11.06 9 646632 11774 109930884
White blood cell count increased 41.44 11.06 364 646277 96478 109846180
Partial seizures 41.44 11.06 8 646633 11341 109931317
Transaminases increased 41.36 11.06 210 646431 63180 109879478
Porphyria acute 41.31 11.06 218 646423 18562 109924096
Pleural fibrosis 41.16 11.06 83 646558 4225 109938433
Blindness 41.08 11.06 95 646546 36264 109906394
Spinal column injury 41.08 11.06 59 646582 2272 109940386
Antibody test positive 41.04 11.06 69 646572 3051 109939607
Blood magnesium decreased 40.93 11.06 34 646607 19962 109922696
Cold sweat 40.89 11.06 41 646600 21990 109920668
Osteoporotic fracture 40.86 11.06 94 646547 5243 109937415
Hypernatraemia 40.80 11.06 27 646614 17806 109924852
Histoplasmosis disseminated 40.74 11.06 78 646563 3821 109938837
Chromaturia 40.71 11.06 68 646573 29292 109913366
Kidney transplant rejection 40.62 11.06 10 646631 11977 109930681
Brain injury 40.61 11.06 14 646627 13462 109929196
Phospholipidosis 40.55 11.06 25 646616 311 109942347
Aortic stenosis 40.35 11.06 13 646628 13046 109929612
Supraventricular tachycardia 40.34 11.06 50 646591 24372 109918286
Dissociation 40.34 11.06 5 646636 9837 109932821
Stress cardiomyopathy 40.31 11.06 21 646620 15785 109926873
Influenza 40.12 11.06 721 645920 168380 109774278
Multiple sclerosis 39.99 11.06 55 646586 25643 109917015
Neurologic neglect syndrome 39.93 11.06 4 646637 9294 109933364
Hypomania 39.92 11.06 6 646635 10204 109932454
Peripheral sensory neuropathy 39.89 11.06 24 646617 16656 109926002
Femoral neck fracture 39.74 11.06 12 646629 12555 109930103
Visual acuity reduced 39.73 11.06 80 646561 32093 109910565
Amylase increased 39.51 11.06 12 646629 12507 109930151
Nervousness 39.49 11.06 99 646542 36752 109905906
Neuropsychiatric lupus 39.44 11.06 22 646619 224 109942434
Cardiovascular disorder 39.30 11.06 45 646596 22715 109919943
Atrioventricular block first degree 39.19 11.06 17 646624 14208 109928450
Staphylococcal sepsis 39.16 11.06 27 646614 17427 109925231
Femur fracture 39.06 11.06 415 646226 44054 109898604
Lung infiltration 39.04 11.06 52 646589 24576 109918082
Cardiac failure acute 39.03 11.06 50 646591 24028 109918630
Joint lock 39.01 11.06 73 646568 3515 109939143
Drug dose omission by device 38.97 11.06 18 646623 14498 109928160
Right ventricular failure 38.95 11.06 57 646584 25897 109916761
Skin burning sensation 38.95 11.06 42 646599 21783 109920875
Colorectal cancer 38.94 11.06 4 646637 9110 109933548
Left ventricular dysfunction 38.91 11.06 48 646593 23445 109919213
Arteriospasm coronary 38.86 11.06 4 646637 9096 109933562
Gastritis erosive 38.79 11.06 11 646630 11989 109930669
Drug level above therapeutic 38.63 11.06 10 646631 11578 109931080
Staphylococcal bacteraemia 38.54 11.06 25 646616 16663 109925995
Ankle arthroplasty 38.43 11.06 60 646581 2491 109940167
Ventricular tachycardia 38.41 11.06 156 646485 49853 109892805
Foetal growth restriction 38.20 11.06 66 646575 2984 109939674
Hair follicle tumour benign 38.18 11.06 27 646614 429 109942229
Eye pain 38.03 11.06 157 646484 49942 109892716
Drug specific antibody 37.81 11.06 63 646578 2765 109939893
Nephropathy toxic 37.77 11.06 64 646577 27414 109915244
Affect lability 37.77 11.06 32 646609 18605 109924053
Mass excision 37.62 11.06 25 646616 357 109942301
Pancreatic carcinoma 37.57 11.06 20 646621 14852 109927806
Borderline leprosy 37.52 11.06 14 646627 48 109942610
Sinus disorder 37.40 11.06 85 646556 32643 109910015
Coma scale abnormal 37.38 11.06 6 646635 9720 109932938
Peritonitis bacterial 37.26 11.06 8 646633 10525 109932133
Pneumonia fungal 37.04 11.06 20 646621 14734 109927924
Metastasis 37.00 11.06 3 646638 8264 109934394
Blood test abnormal 37.00 11.06 69 646572 28485 109914173
Rash macular 36.91 11.06 110 646531 38576 109904082
Limb deformity 36.78 11.06 73 646568 3673 109938985
Faeces soft 36.75 11.06 10 646631 11200 109931458
Generalised oedema 36.52 11.06 78 646563 30626 109912032
Hepatic cancer 36.48 11.06 10 646631 11146 109931512
Apnoea 36.48 11.06 17 646624 13622 109929036
Blood loss anaemia 36.47 11.06 31 646610 17994 109924664
Eyelid oedema 36.44 11.06 22 646619 15240 109927418
Sickle cell anaemia with crisis 36.43 11.06 6 646635 9539 109933119
Peritonitis 36.20 11.06 86 646555 32521 109910137
Parosmia 35.92 11.06 16 646625 13164 109929494
Forced expiratory volume decreased 35.90 11.06 16 646625 13160 109929498
Sexual dysfunction 35.79 11.06 4 646637 8526 109934132
Normal newborn 35.76 11.06 235 646406 21661 109920997
Personality change 35.72 11.06 10 646631 10992 109931666
Red blood cell vacuolisation 35.65 11.06 10 646631 8 109942650
Laryngeal disorder 35.64 11.06 39 646602 1134 109941524
Device breakage 35.55 11.06 18 646623 13751 109928907
Pleural thickening 35.52 11.06 68 646573 3331 109939327
Cardiomegaly 35.49 11.06 73 646568 29057 109913601
Mouth ulceration 35.42 11.06 434 646207 47704 109894954
Cytopenia 35.41 11.06 77 646564 30039 109912619
Cytomegalovirus viraemia 35.39 11.06 31 646610 17733 109924925
Disseminated strongyloidiasis 35.38 11.06 29 646612 580 109942078
Eating disorder 35.38 11.06 80 646561 30778 109911880
Normochromic normocytic anaemia 35.35 11.06 16 646625 13041 109929617
Incoherent 34.86 11.06 4 646637 8354 109934304
Aplasia 34.84 11.06 3 646638 7870 109934788
Fear of injection 34.76 11.06 123 646518 8788 109933870
Fear 34.74 11.06 51 646590 23142 109919516
Tender joint count 34.70 11.06 42 646599 1365 109941293
Victim of child abuse 34.62 11.06 39 646602 1172 109941486
Renal disorder 34.55 11.06 160 646481 49319 109893339
Hiccups 34.48 11.06 16 646625 12853 109929805
Hypotonia 34.48 11.06 25 646616 15720 109926938
Lupus myocarditis 34.40 11.06 15 646626 84 109942574
Motor dysfunction 34.33 11.06 56 646585 24350 109918308
Migraine 34.29 11.06 1277 645364 170375 109772283
Klebsiella infection 34.07 11.06 40 646601 19969 109922689
Gastric cancer 33.94 11.06 11 646630 10997 109931661
Decubitus ulcer 33.77 11.06 34 646607 18202 109924456
Pulmonary arterial hypertension 33.74 11.06 89 646552 32479 109910179
Blood phosphorus decreased 33.71 11.06 3 646638 7662 109934996
Body tinea 33.63 11.06 51 646590 2064 109940594
Cachexia 33.58 11.06 17 646624 12988 109929670
Hyperventilation 33.32 11.06 6 646635 8941 109933717
Gangrene 33.19 11.06 28 646613 16313 109926345
Immune thrombocytopenia 33.17 11.06 50 646591 22444 109920214
Brain natriuretic peptide increased 33.17 11.06 12 646629 11197 109931461
Large intestine perforation 33.15 11.06 29 646612 16600 109926058
Extremity contracture 33.15 11.06 46 646595 1715 109940943
Hepatitis C 33.12 11.06 16 646625 12557 109930101
Skin irritation 33.09 11.06 28 646613 16291 109926367
Pulmonary toxicity 33.06 11.06 197 646444 17549 109925109
Hiatus hernia 32.94 11.06 70 646571 27536 109915122
Bradykinesia 32.87 11.06 11 646630 10777 109931881
Diffuse alopecia 32.81 11.06 40 646601 1310 109941348
Drug reaction with eosinophilia and systemic symptoms 32.77 11.06 314 646327 81781 109860877
Depressive symptom 32.77 11.06 5 646636 8409 109934249
Apathy 32.76 11.06 28 646613 16211 109926447
Hyperlipidaemia 32.73 11.06 104 646537 35744 109906914
Facial paralysis 32.73 11.06 57 646584 24157 109918501
Amenorrhoea 32.68 11.06 7 646634 9224 109933434
Loss of employment 32.64 11.06 65 646576 3279 109939379
BK virus infection 32.56 11.06 18 646623 13088 109929570
Abnormal dreams 32.56 11.06 17 646624 12763 109929895
Radiculopathy 32.56 11.06 39 646602 19297 109923361
Joint ankylosis 32.55 11.06 55 646586 2442 109940216
Bone disorder 32.54 11.06 224 646417 20968 109921690
Cytology abnormal 32.52 11.06 22 646619 324 109942334
Metabolic encephalopathy 32.46 11.06 12 646629 11048 109931610
Swollen joint count 32.36 11.06 118 646523 8556 109934102
Injection site mass 32.31 11.06 59 646582 24554 109918104
Cushingoid 32.26 11.06 145 646496 11567 109931091
Anovulatory cycle 32.17 11.06 16 646625 126 109942532
Staphylococcal infection 32.14 11.06 258 646383 69686 109872972
Retinal degeneration 32.09 11.06 44 646597 1622 109941036
Drug level below therapeutic 32.08 11.06 14 646627 11659 109930999
Infiltration anaesthesia 31.89 11.06 17 646624 157 109942501
Aortic arteriosclerosis 31.88 11.06 12 646629 10926 109931732
Stress 31.82 11.06 429 646212 104919 109837739
Sensory disturbance 31.70 11.06 33 646608 17396 109925262
Clostridium test positive 31.67 11.06 12 646629 10881 109931777
Product preparation error 31.60 11.06 12 646629 10867 109931791
Wrist surgery 31.60 11.06 32 646609 849 109941809
Tricuspid valve incompetence 31.54 11.06 57 646584 23816 109918842
Metabolic disorder 31.53 11.06 11 646630 10499 109932159
Neurological symptom 31.38 11.06 27 646614 15581 109927077
Heart rate abnormal 31.38 11.06 3 646638 7235 109935423
Breast cancer stage II 31.24 11.06 270 646371 27105 109915553
Extra dose administered 31.24 11.06 16 646625 12143 109930515
General physical health deterioration 31.18 11.06 2890 643751 422405 109520253
Angina unstable 31.17 11.06 30 646611 16402 109926256
Hepatitis cholestatic 31.13 11.06 34 646607 17532 109925126
Atrial flutter 31.11 11.06 59 646582 24203 109918455
Overlap syndrome 31.11 11.06 120 646521 8939 109933719
Hypoventilation 31.02 11.06 5 646636 8076 109934582
Synovial fluid analysis 30.98 11.06 56 646585 2625 109940033
Spondylitis 30.95 11.06 140 646501 11198 109931460
Hypovolaemic shock 30.85 11.06 24 646617 14559 109928099
Tension headache 30.75 11.06 9 646632 9609 109933049
Vascular access complication 30.75 11.06 54 646587 2474 109940184
Dermatitis acneiform 30.73 11.06 18 646623 12677 109929981
Blood albumin decreased 30.64 11.06 73 646568 27579 109915079
Hot flush 30.61 11.06 243 646398 65793 109876865
Myasthenia gravis 30.59 11.06 49 646592 21462 109921196
Pulmonary alveolar haemorrhage 30.49 11.06 44 646597 20106 109922552
Gait disturbance 30.44 11.06 1951 644690 276257 109666401
Latent tuberculosis 30.40 11.06 70 646571 3907 109938751
Scleroderma renal crisis 30.35 11.06 32 646609 891 109941767
Wrong product administered 30.35 11.06 13 646628 10947 109931711
Multiple-drug resistance 30.33 11.06 20 646621 13215 109929443
Non-small cell lung cancer 30.26 11.06 5 646636 7930 109934728
Myopathy toxic 30.18 11.06 38 646603 1287 109941371
Intestinal ischaemia 30.15 11.06 30 646611 16149 109926509
Colon cancer 30.06 11.06 31 646610 16412 109926246
Red cell distribution width decreased 30.06 11.06 50 646591 2191 109940467
Restrictive cardiomyopathy 30.05 11.06 34 646607 1027 109941631
Skin discolouration 30.04 11.06 166 646475 48880 109893778
Hypoaesthesia oral 30.03 11.06 33 646608 16969 109925689
Fluid intake reduced 30.02 11.06 3 646638 6983 109935675
Device use error 30.00 11.06 8 646633 9081 109933577
Paradoxical drug reaction 29.93 11.06 10 646631 9807 109932851
Hyperlactacidaemia 29.92 11.06 6 646635 8280 109934378
Renal tubular disorder 29.90 11.06 4 646637 7425 109935233
Respiration abnormal 29.89 11.06 10 646631 9799 109932859
Disseminated varicella zoster virus infection 29.59 11.06 37 646604 1244 109941414
Gastric ulcer haemorrhage 29.54 11.06 11 646630 10083 109932575
Atrioventricular block 29.54 11.06 33 646608 16844 109925814
Cerebral ischaemia 29.53 11.06 17 646624 12087 109930571
Antinuclear antibody positive 29.51 11.06 119 646522 9049 109933609
Hip fracture 29.35 11.06 106 646535 35045 109907613
Renal function test abnormal 29.29 11.06 8 646633 8938 109933720
Pulmonary haemorrhage 29.00 11.06 32 646609 16424 109926234
Pulse absent 28.80 11.06 15 646626 11277 109931381
Viral infection 28.78 11.06 187 646454 52952 109889706
Shrinking lung syndrome 28.76 11.06 16 646625 162 109942496
Leukoencephalopathy 28.68 11.06 9 646632 9186 109933472
Exposure via skin contact 28.63 11.06 21 646620 13126 109929532
Nail operation 28.58 11.06 42 646599 1652 109941006
Dizziness postural 28.50 11.06 26 646615 14583 109928075
Retinal haemorrhage 28.41 11.06 10 646631 9491 109933167
Refusal of treatment by patient 28.38 11.06 10 646631 9484 109933174
Drooling 28.36 11.06 4 646637 7135 109935523
Fibrin D dimer increased 28.36 11.06 11 646630 9834 109932824
Breast cancer metastatic 28.30 11.06 15 646626 11166 109931492
Fracture delayed union 28.05 11.06 48 646593 2153 109940505
Sleep terror 27.98 11.06 3 646638 6607 109936051
Bacterial sepsis 27.88 11.06 13 646628 10413 109932245
Cartilage atrophy 27.87 11.06 16 646625 173 109942485
Azotaemia 27.87 11.06 12 646629 10073 109932585
Respiratory acidosis 27.70 11.06 24 646617 13802 109928856
Intestinal perforation 27.68 11.06 50 646591 20894 109921764
Cardiac failure chronic 27.64 11.06 24 646617 13787 109928871
Epidural lipomatosis 27.57 11.06 46 646595 2021 109940637
Cutaneous coccidioidomycosis 27.55 11.06 9 646632 18 109942640
Parainfluenzae virus infection 27.49 11.06 4 646637 6970 109935688
Neuritis 27.48 11.06 5 646636 7394 109935264
Cystitis 27.47 11.06 250 646391 65786 109876872
Eructation 27.44 11.06 25 646616 14032 109928626
Endophthalmitis 27.41 11.06 7 646634 8180 109934478
Infusion site pain 27.39 11.06 37 646604 17382 109925276
Catatonia 27.39 11.06 16 646625 11284 109931374
Muscle spasticity 27.38 11.06 326 646315 35589 109907069
Double stranded DNA antibody positive 27.38 11.06 24 646617 528 109942130
Intermenstrual bleeding 27.28 11.06 4 646637 6930 109935728
Tenosynovitis stenosans 27.08 11.06 63 646578 3540 109939118
Carotid artery occlusion 27.04 11.06 11 646630 9554 109933104
Pneumonia bacterial 27.03 11.06 72 646569 26189 109916469
Duodenitis 26.95 11.06 10 646631 9186 109933472
Nasal congestion 26.94 11.06 408 646233 97874 109844784
Diarrhoea haemorrhagic 26.91 11.06 31 646610 15608 109927050
Respiratory tract infection 26.89 11.06 278 646363 71339 109871319
Cystoid macular oedema 26.82 11.06 54 646587 2746 109939912
Cytomegalovirus infection reactivation 26.80 11.06 41 646600 18292 109924366
Nasal oedema 26.78 11.06 4 646637 6835 109935823
Electrocardiogram ST segment elevation 26.78 11.06 10 646631 9150 109933508
Obsessive-compulsive disorder 26.66 11.06 5 646636 7236 109935422
Venoocclusive disease 26.58 11.06 3 646638 6347 109936311
Device failure 26.48 11.06 5 646636 7202 109935456
Cerebral atrophy 26.42 11.06 10 646631 9075 109933583
Paronychia 26.42 11.06 16 646625 11065 109931593
Clostridial infection 26.33 11.06 3 646638 6299 109936359
Petit mal epilepsy 26.16 11.06 6 646635 7541 109935117
Asthma 25.95 11.06 1197 645444 249094 109693564
Haematocrit decreased 25.92 11.06 254 646387 65863 109876795
Ankle operation 25.79 11.06 36 646605 1350 109941308
Taste disorder 25.77 11.06 531 646110 64856 109877802
Cerebral haematoma 25.77 11.06 12 646629 9620 109933038
Nephrolithiasis 25.69 11.06 255 646386 65957 109876701
Escherichia sepsis 25.68 11.06 14 646627 10258 109932400
Injection site swelling 25.67 11.06 234 646407 61556 109881102
Hepatic necrosis 25.57 11.06 13 646628 9909 109932749
Blood pressure increased 25.52 11.06 1242 645399 257131 109685527
Blood lactic acid increased 25.50 11.06 33 646608 15788 109926870
Bronchiectasis 25.49 11.06 118 646523 36375 109906283
Injection site erythema 25.46 11.06 392 646249 93784 109848874
Hypercapnia 25.39 11.06 17 646624 11142 109931516
Hepatocellular carcinoma 25.38 11.06 13 646628 9867 109932791
Diabetes insipidus 25.37 11.06 4 646637 6566 109936092
Electrocardiogram abnormal 25.33 11.06 44 646597 18665 109923993
Coronary artery occlusion 25.31 11.06 33 646608 15739 109926919
Hypoxic-ischaemic encephalopathy 25.30 11.06 10 646631 8837 109933821
Hepatic lesion 25.29 11.06 9 646632 8484 109934174
Back disorder 25.28 11.06 209 646432 20713 109921945
Ocular toxicity 25.26 11.06 35 646606 1303 109941355
Pulmonary thrombosis 25.26 11.06 153 646488 13710 109928948
Transaminases abnormal 25.20 11.06 30 646611 958 109941700
Escherichia bacteraemia 25.19 11.06 14 646627 10150 109932508
Treatment noncompliance 25.13 11.06 289 646352 72701 109869957
Systemic infection 25.11 11.06 13 646628 9806 109932852
Cardiac murmur 24.99 11.06 68 646573 24560 109918098
Erysipelas 24.98 11.06 24 646617 13134 109929524
Polydipsia 24.94 11.06 7 646634 7681 109934977
Lung opacity 24.87 11.06 19 646622 11633 109931025
Insomnia 24.74 11.06 2439 644202 358151 109584507
Hallucinations, mixed 24.57 11.06 10 646631 8683 109933975
Drug screen positive 24.53 11.06 4 646637 6406 109936252
Somnambulism 24.51 11.06 4 646637 6401 109936257
Restless legs syndrome 24.24 11.06 69 646572 24557 109918101
Product monitoring error 24.07 11.06 11 646630 8916 109933742
Bradyphrenia 23.93 11.06 20 646621 11708 109930950
Choking 23.86 11.06 32 646609 15078 109927580
Respiratory depression 23.85 11.06 101 646540 31900 109910758
Dermatomyositis 23.76 11.06 68 646573 4338 109938320
Central nervous system lymphoma 23.73 11.06 54 646587 2990 109939668
Atrial tachycardia 23.69 11.06 12 646629 9166 109933492
Complication of device insertion 23.66 11.06 11 646630 8827 109933831
Congestive cardiomyopathy 23.60 11.06 29 646612 14190 109928468
Product storage error 23.57 11.06 58 646583 21670 109920988
Lupus enteritis 23.56 11.06 11 646630 74 109942584
Cutaneous vasculitis 23.52 11.06 141 646500 12588 109930070
Central nervous system lesion 23.49 11.06 34 646607 15519 109927139
Blood chloride decreased 23.41 11.06 12 646629 9103 109933555
Anosmia 23.39 11.06 23 646618 12449 109930209
Nystagmus 23.31 11.06 20 646621 11557 109931101
Rotator cuff repair 23.27 11.06 45 646596 2221 109940437
Respiratory symptom 23.24 11.06 32 646609 14913 109927745
General symptom 23.24 11.06 108 646533 8738 109933920
Peripheral coldness 22.98 11.06 46 646595 18494 109924164
Mean platelet volume decreased 22.96 11.06 56 646585 3244 109939414
Ulcer haemorrhage 22.89 11.06 217 646424 22354 109920304
Placenta accreta 22.70 11.06 15 646626 212 109942446
Palindromic rheumatism 22.69 11.06 19 646622 392 109942266
Therapeutic product ineffective for unapproved indication 22.67 11.06 17 646624 297 109942361
Blood magnesium increased 22.59 11.06 61 646580 3762 109938896
Leukopenia 22.48 11.06 680 645961 148111 109794547
Shoulder operation 22.43 11.06 57 646584 3388 109939270
Enterococcal infection 22.38 11.06 54 646587 20312 109922346
Injection site haemorrhage 22.36 11.06 108 646533 32920 109909738
Type I hypersensitivity 22.32 11.06 5 646636 6388 109936270
Gastrointestinal pain 22.32 11.06 132 646509 11728 109930930
Cholecystitis chronic 22.26 11.06 14 646627 9486 109933172
Haemorrhage subcutaneous 22.25 11.06 3 646638 5536 109937122
Hyperreflexia 22.19 11.06 14 646627 9471 109933187
Vasculitic rash 22.18 11.06 44 646597 2213 109940445
Rash maculo-papular 22.14 11.06 303 646338 73919 109868739
Adenovirus infection 22.13 11.06 19 646622 10975 109931683
Total lung capacity decreased 22.12 11.06 7 646634 7107 109935551
Initial insomnia 22.10 11.06 17 646624 10372 109932286
Photosensitivity reaction 22.10 11.06 238 646403 25351 109917307
Atelectasis 22.08 11.06 125 646516 36587 109906071
Cataract 22.04 11.06 615 646026 78870 109863788
Vaginal haemorrhage 22.02 11.06 74 646567 25000 109917658
Occult blood positive 21.98 11.06 8 646633 7437 109935221
Affective disorder 21.93 11.06 20 646621 11221 109931437
Blood creatine increased 21.89 11.06 21 646620 11500 109931158
Eye movement disorder 21.89 11.06 15 646626 9713 109932945
Pyelonephritis 21.85 11.06 75 646566 25175 109917483
Escherichia infection 21.81 11.06 69 646572 23747 109918911
Persecutory delusion 21.81 11.06 5 646636 6286 109936372
Haemorrhoidal haemorrhage 21.78 11.06 10 646631 8083 109934575
Tearfulness 21.74 11.06 8 646633 7387 109935271
Bronchitis chronic 21.74 11.06 71 646570 4869 109937789
Therapy change 21.73 11.06 16 646625 9981 109932677
Product substitution issue 21.69 11.06 66 646575 22995 109919663
Fistula 21.62 11.06 35 646606 15264 109927394
Autoimmune haemolytic anaemia 21.59 11.06 18 646623 10549 109932109
Musculoskeletal chest pain 21.52 11.06 91 646550 28756 109913902
Disease susceptibility 21.43 11.06 17 646624 324 109942334
Mitral valve incompetence 21.41 11.06 111 646530 33218 109909440
Mite allergy 21.38 11.06 4 646637 5799 109936859
Short stature 21.38 11.06 29 646612 1058 109941600
Pneumonia cytomegaloviral 21.35 11.06 7 646634 6947 109935711
Human herpesvirus 6 infection 21.33 11.06 6 646635 6575 109936083
Blood pressure systolic increased 21.32 11.06 636 646005 82355 109860303
Pseudomonas infection 21.32 11.06 87 646554 27766 109914892
Osteopenia 21.28 11.06 211 646430 21998 109920660
Bacterial test positive 21.25 11.06 10 646631 7967 109934691
Intervertebral disc compression 21.24 11.06 33 646608 1364 109941294
Systemic inflammatory response syndrome 21.23 11.06 27 646614 13016 109929642
Subcutaneous drug absorption impaired 21.23 11.06 95 646546 7564 109935094
Peripheral ischaemia 21.19 11.06 20 646621 11038 109931620
Psychiatric decompensation 21.18 11.06 4 646637 5761 109936897
Wound dehiscence 21.18 11.06 10 646631 7952 109934706
Stress at work 21.14 11.06 32 646609 1293 109941365
Performance status decreased 21.13 11.06 8 646633 7258 109935400
Sputum increased 21.11 11.06 4 646637 5747 109936911
Hepatomegaly 21.08 11.06 60 646581 21354 109921304
Infection reactivation 21.06 11.06 62 646579 4019 109938639
Product use in unapproved indication 21.05 11.06 2954 643687 444423 109498235
Blood disorder 20.93 11.06 16 646625 9794 109932864
Chorioretinitis 20.93 11.06 33 646608 1382 109941276
Rheumatic disorder 20.92 11.06 57 646584 3534 109939124
Brain herniation 20.85 11.06 13 646628 8850 109933808
Skin reaction 20.81 11.06 202 646439 20942 109921716
Concomitant disease aggravated 20.80 11.06 40 646601 16324 109926334
Plasmacytoma 20.79 11.06 3 646638 5259 109937399
Gastrointestinal inflammation 20.78 11.06 15 646626 9454 109933204
Type 1 lepra reaction 20.74 11.06 10 646631 73 109942585
Anaphylactoid reaction 20.73 11.06 7 646634 6819 109935839
Exercise tolerance decreased 20.68 11.06 24 646617 12043 109930615
Muscle tightness 20.64 11.06 34 646607 14728 109927930
Snoring 20.53 11.06 7 646634 6777 109935881
Sudden cardiac death 20.53 11.06 4 646637 5633 109937025
Blood immunoglobulin E increased 20.52 11.06 9 646632 7473 109935185
Lung neoplasm malignant 20.47 11.06 115 646526 33727 109908931
Fungal infection 20.41 11.06 194 646447 50612 109892046
Head discomfort 20.39 11.06 51 646590 18949 109923709
Metastases to peritoneum 20.39 11.06 4 646637 5606 109937052
Red blood cells urine positive 20.38 11.06 3 646638 5182 109937476
Allergy to vaccine 20.25 11.06 14 646627 214 109942444
Procedural complication 20.23 11.06 12 646629 8393 109934265
Faecal calprotectin increased 20.21 11.06 7 646634 6712 109935946
Clonus 20.21 11.06 13 646628 8703 109933955
Retinal injury 20.18 11.06 19 646622 460 109942198
Body mass index abnormal 20.17 11.06 26 646615 902 109941756
Thinking abnormal 20.14 11.06 36 646605 15104 109927554
Mixed connective tissue disease 20.13 11.06 18 646623 407 109942251
Middle lobe syndrome 20.11 11.06 8 646633 34 109942624
Arthritis bacterial 20.09 11.06 120 646521 10700 109931958
Breast cancer stage I 20.08 11.06 9 646632 7378 109935280
Nodular regenerative hyperplasia 20.04 11.06 35 646606 1596 109941062
Smear cervix abnormal 19.92 11.06 47 646594 2665 109939993
Ocular hyperaemia 19.90 11.06 141 646500 39145 109903513
Lacunar infarction 19.88 11.06 6 646635 6280 109936378
Gastrointestinal necrosis 19.83 11.06 7 646634 6633 109936025
Tension 19.82 11.06 3 646638 5075 109937583
Sensation of foreign body 19.74 11.06 11 646630 7964 109934694
Rales 19.74 11.06 76 646565 24663 109917995
Secretion discharge 19.73 11.06 193 646448 20051 109922607
Oral candidiasis 19.70 11.06 167 646474 44593 109898065
Macular degeneration 19.66 11.06 63 646578 21596 109921062
Trigger finger 19.62 11.06 70 646571 5022 109937636
Soft tissue disorder 19.60 11.06 55 646586 3469 109939189
Product physical issue 19.60 11.06 3 646638 5033 109937625
Internal haemorrhage 19.55 11.06 18 646623 10053 109932605
Hepatitis fulminant 19.53 11.06 13 646628 8547 109934111
Brain death 19.51 11.06 7 646634 6566 109936092
Hypocomplementaemia 19.48 11.06 16 646625 321 109942337
Blood thyroid stimulating hormone increased 19.47 11.06 26 646615 12275 109930383
Unevaluable event 19.43 11.06 237 646404 58990 109883668
Immune-mediated myositis 19.39 11.06 6 646635 6180 109936478
Urine analysis abnormal 19.39 11.06 8 646633 6889 109935769
Protein total decreased 19.38 11.06 21 646620 10869 109931789
Pelvic pain 19.38 11.06 40 646601 15902 109926756
Eosinophilic pneumonia 19.34 11.06 9 646632 7218 109935440
Varices oesophageal 19.28 11.06 9 646632 7206 109935452
PaO2/FiO2 ratio decreased 19.24 11.06 8 646633 39 109942619
Uterine perforation 19.12 11.06 8 646633 6832 109935826
Prostate cancer metastatic 19.11 11.06 3 646638 4940 109937718
Intracranial pressure increased 19.10 11.06 20 646621 10515 109932143
Anal abscess 19.04 11.06 24 646617 11614 109931044
Hypofibrinogenaemia 19.02 11.06 44 646597 2463 109940195
Frequent bowel movements 19.01 11.06 298 646343 71092 109871566
Mycobacterium tuberculosis complex test positive 18.97 11.06 52 646589 3236 109939422
Anticoagulation drug level increased 18.95 11.06 26 646615 959 109941699
Thrombosis in device 18.94 11.06 4 646637 5323 109937335
Exposure via ingestion 18.88 11.06 3 646638 4897 109937761
Intestinal polyp 18.84 11.06 43 646598 2386 109940272
Areflexia 18.79 11.06 8 646633 6761 109935897
Mean cell haemoglobin concentration decreased 18.76 11.06 5 646636 5677 109936981
Sinus congestion 18.70 11.06 103 646538 30356 109912302
Feeling hot 18.70 11.06 398 646243 90708 109851950
Granulomatous dermatitis 18.67 11.06 19 646622 507 109942151
Eosinophil count decreased 18.58 11.06 6 646635 6012 109936646
Lung adenocarcinoma 18.55 11.06 17 646624 9514 109933144
Transplant failure 18.52 11.06 5 646636 5630 109937028
Low density lipoprotein increased 18.51 11.06 21 646620 10645 109932013
Ventricular hypokinesia 18.48 11.06 23 646618 11191 109931467
Cytomegalovirus test positive 18.46 11.06 9 646632 7027 109935631
Neoplasm recurrence 18.46 11.06 4 646637 5228 109937430
Catheter site infection 18.45 11.06 12 646629 7988 109934670
Spinal meningioma benign 18.43 11.06 10 646631 96 109942562
Skin abrasion 18.41 11.06 42 646599 16109 109926549
Pericardial haemorrhage 18.38 11.06 4 646637 5213 109937445
Metabolic alkalosis 18.32 11.06 5 646636 5590 109937068
Natural killer-cell leukaemia 18.25 11.06 10 646631 98 109942560
Renal cancer 18.24 11.06 30 646611 13004 109929654
Carcinoid tumour pulmonary 18.21 11.06 17 646624 407 109942251
Therapeutic response shortened 18.18 11.06 100 646541 29483 109913175
Candida infection 18.17 11.06 186 646455 47823 109894835
Diverticulum intestinal haemorrhagic 18.17 11.06 3 646638 4760 109937898
Biliary obstruction 18.14 11.06 5 646636 5553 109937105
Throat tightness 18.06 11.06 118 646523 33371 109909287
Embolism 18.05 11.06 43 646598 16246 109926412
External auditory canal atresia 18.05 11.06 6 646635 13 109942645
Scleritis 17.96 11.06 71 646570 5349 109937309
Dermatitis exfoliative 17.95 11.06 24 646617 11323 109931335
Spinal fusion surgery 17.94 11.06 103 646538 9053 109933605
Increased appetite 17.85 11.06 38 646603 14939 109927719
Lymphadenopathy 17.84 11.06 264 646377 63571 109879087
Steroid dependence 17.84 11.06 14 646627 8455 109934203
Ventricular extrasystoles 17.78 11.06 70 646571 22571 109920087
Complement factor C3 decreased 17.77 11.06 16 646625 365 109942293
Iris coloboma 17.74 11.06 6 646635 14 109942644
Retinal coloboma 17.74 11.06 6 646635 14 109942644
Embolic stroke 17.73 11.06 15 646626 8728 109933930
Muscle haemorrhage 17.70 11.06 9 646632 6860 109935798
Blood pH decreased 17.68 11.06 3 646638 4666 109937992
Antineutrophil cytoplasmic antibody positive 17.66 11.06 4 646637 5072 109937586
Cytomegalovirus mucocutaneous ulcer 17.63 11.06 11 646630 140 109942518
Rhinovirus infection 17.58 11.06 26 646615 11763 109930895
Blood culture positive 17.48 11.06 16 646625 8960 109933698
Communication disorder 17.48 11.06 4 646637 5035 109937623
Supraventricular extrasystoles 17.44 11.06 13 646628 8060 109934598
Infective tenosynovitis 17.43 11.06 18 646623 489 109942169
Complication of device removal 17.42 11.06 3 646638 4617 109938041
Carbuncle 17.41 11.06 31 646610 1436 109941222
Laryngeal oedema 17.36 11.06 19 646622 9788 109932870
Localised oedema 17.30 11.06 17 646624 9206 109933452
Obstruction 17.29 11.06 6 646635 5746 109936912
Product administered to patient of inappropriate age 17.29 11.06 13 646628 8023 109934635
Psychiatric symptom 17.26 11.06 17 646624 9196 109933462
Drug specific antibody present 17.26 11.06 96 646545 8338 109934320
Mean cell volume increased 17.25 11.06 14 646627 8316 109934342
Bruxism 17.25 11.06 4 646637 4990 109937668
Knee deformity 17.24 11.06 32 646609 1531 109941127
Expired product administered 17.21 11.06 14 646627 8306 109934352
Social avoidant behaviour 17.21 11.06 5 646636 5364 109937294
Ischaemic cardiomyopathy 17.18 11.06 13 646628 7998 109934660
Oral lichen planus 17.13 11.06 24 646617 903 109941755
Metastases to spine 17.08 11.06 5 646636 5338 109937320
Infected seroma 17.08 11.06 9 646632 81 109942577
Squamous cell carcinoma of skin 17.08 11.06 48 646593 17155 109925503
Thrombophlebitis 17.07 11.06 12 646629 7667 109934991
Neoplasm 16.98 11.06 24 646617 11063 109931595
Herpes simplex hepatitis 16.98 11.06 22 646619 767 109941891
Blood chloride increased 16.95 11.06 8 646633 6364 109936294
Device related sepsis 16.93 11.06 12 646629 7635 109935023
Immune-mediated lung disease 16.88 11.06 5 646636 5298 109937360
Blood pressure inadequately controlled 16.87 11.06 12 646629 7621 109935037
Product administration interrupted 16.75 11.06 25 646616 11267 109931391
Behaviour disorder 16.73 11.06 19 646622 9628 109933030
Endocarditis 16.72 11.06 33 646608 13338 109929320
Screaming 16.68 11.06 4 646637 4877 109937781
Chronic lymphocytic leukaemia 16.65 11.06 7 646634 5961 109936697
Klebsiella bacteraemia 16.62 11.06 4 646637 4865 109937793
Oxygen saturation abnormal 16.62 11.06 6 646635 5605 109937053
Application site erythema 16.61 11.06 6 646635 5604 109937054
Hepatitis E 16.59 11.06 3 646638 4456 109938202
Pathological fracture 16.56 11.06 28 646613 12004 109930654
Herpes simplex viraemia 16.55 11.06 20 646621 649 109942009
Platelet count abnormal 16.54 11.06 8 646633 6274 109936384
Lupus endocarditis 16.51 11.06 13 646628 245 109942413
Libido decreased 16.50 11.06 7 646634 5928 109936730
Inflammatory bowel disease 16.48 11.06 11 646630 7223 109935435
Posture abnormal 16.48 11.06 3 646638 4435 109938223
Aplasia pure red cell 16.47 11.06 19 646622 9559 109933099
Complement factor C4 decreased 16.45 11.06 15 646626 348 109942310
Coronary arterial stent insertion 16.40 11.06 7 646634 5908 109936750
Adenoiditis 16.38 11.06 7 646634 37 109942621
Compartment syndrome 16.38 11.06 7 646634 5903 109936755
Hydrocephalus 16.35 11.06 22 646619 10353 109932305
Carotid artery stenosis 16.34 11.06 18 646623 9245 109933413
Unintended pregnancy 16.31 11.06 4 646637 4804 109937854
Red blood cell count decreased 16.29 11.06 279 646362 65644 109877014
Polycystic ovaries 16.25 11.06 4 646637 4792 109937866
Connective tissue disorder 16.24 11.06 34 646607 1778 109940880
Hepatic cyst 16.22 11.06 13 646628 7770 109934888
Gingivitis 16.19 11.06 22 646619 10309 109932349
Multiple allergies 16.18 11.06 125 646516 12138 109930520
Acute cutaneous lupus erythematosus 16.12 11.06 16 646625 414 109942244
Blood pressure systolic decreased 16.11 11.06 34 646607 13407 109929251
Limb operation 16.09 11.06 56 646585 3968 109938690
Prescription drug used without a prescription 16.07 11.06 6 646635 5490 109937168
Neutrophil count abnormal 16.05 11.06 5 646636 5127 109937531
Disease complication 15.99 11.06 7 646634 5820 109936838
Hypercalcaemia 15.87 11.06 371 646270 46286 109896372
Impetigo herpetiformis 15.85 11.06 10 646631 130 109942528
Humerus fracture 15.85 11.06 24 646617 10752 109931906
Carpal tunnel syndrome 15.84 11.06 202 646439 22408 109920250
Pneumothorax 15.82 11.06 131 646510 35154 109907504
Troponin T increased 15.80 11.06 3 646638 4303 109938355
Mood swings 15.79 11.06 74 646567 22738 109919920
C-reactive protein decreased 15.79 11.06 45 646596 2864 109939794
Arthritis salmonella 15.77 11.06 6 646635 22 109942636
Joint space narrowing 15.76 11.06 22 646619 825 109941833
Diabetic eye disease 15.75 11.06 12 646629 215 109942443
Euphoric mood 15.74 11.06 17 646624 8810 109933848
Infection susceptibility increased 15.71 11.06 59 646582 4339 109938319
Acute lymphocytic leukaemia 15.71 11.06 7 646634 5758 109936900
Kidney duplex 15.57 11.06 6 646635 23 109942635
Respiratory tract congestion 15.51 11.06 111 646530 30746 109911912
Retinal artery occlusion 15.50 11.06 3 646638 4246 109938412
Cardiopulmonary failure 15.49 11.06 14 646627 7889 109934769
Grip strength 15.47 11.06 99 646542 9042 109933616
Organising pneumonia 15.47 11.06 38 646603 14205 109928453
Haemoglobin abnormal 15.46 11.06 18 646623 9020 109933638
Lymphopenia 15.46 11.06 155 646486 40015 109902643
Mouth haemorrhage 15.43 11.06 35 646606 13453 109929205
Abdominal wall haematoma 15.43 11.06 7 646634 5698 109936960
Pulmonary function test abnormal 15.41 11.06 5 646636 4995 109937663
Hereditary motor and sensory neuropathy 15.40 11.06 10 646631 137 109942521
Intrauterine infection 15.37 11.06 8 646633 70 109942588
Penicillium infection 15.35 11.06 19 646622 632 109942026
Intra-abdominal haemorrhage 15.34 11.06 6 646635 5336 109937322
Rheumatoid factor quantitative increased 15.30 11.06 5 646636 10 109942648
Heavy menstrual bleeding 15.28 11.06 47 646594 16318 109926340
Mean cell volume decreased 15.26 11.06 70 646571 5632 109937026
Hepatorenal syndrome 15.26 11.06 4 646637 4593 109938065
Hypertensive heart disease 15.26 11.06 4 646637 4592 109938066
Cardiac operation 15.24 11.06 8 646633 5987 109936671
Pneumonia klebsiella 15.23 11.06 10 646631 6622 109936036
Dermatitis bullous 15.21 11.06 52 646589 17477 109925181
Vitamin B12 deficiency 15.17 11.06 22 646619 10033 109932625
Cerebellar syndrome 15.16 11.06 9 646632 6293 109936365
White blood cells urine positive 15.15 11.06 13 646628 7511 109935147
Ganglioneuroma 15.09 11.06 10 646631 142 109942516
Post-traumatic stress disorder 15.07 11.06 10 646631 6586 109936072
Blepharitis 15.04 11.06 4 646637 4548 109938110
Chondropathy 15.03 11.06 44 646597 2843 109939815
Nocturia 15.02 11.06 50 646591 16940 109925718
Odynophagia 15.02 11.06 38 646603 14063 109928595
Gingival hyperpigmentation 14.99 11.06 5 646636 11 109942647
Hyperprolactinaemia 14.98 11.06 10 646631 6565 109936093
Capillary leak syndrome 14.96 11.06 5 646636 4903 109937755
Craniocerebral injury 14.96 11.06 8 646633 5926 109936732
Precancerous cells present 14.93 11.06 27 646614 1266 109941392
Subdural haemorrhage 14.91 11.06 10 646631 6548 109936110
Economic problem 14.90 11.06 3 646638 4128 109938530
Polyp 14.90 11.06 22 646619 9958 109932700
Speech sound disorder 14.88 11.06 7 646634 48 109942610
Blood urine present 14.88 11.06 82 646559 24163 109918495
Clinical trial participant 14.88 11.06 9 646632 108 109942550
Bilirubin conjugated increased 14.82 11.06 9 646632 6215 109936443
Oropharyngeal pain 14.82 11.06 643 645998 134633 109808025
Neck surgery 14.81 11.06 36 646605 2081 109940577
Catheterisation cardiac 14.67 11.06 9 646632 6182 109936476
Humoral immune defect 14.67 11.06 20 646621 733 109941925
Peripheral motor neuropathy 14.67 11.06 3 646638 4083 109938575
Urine abnormality 14.63 11.06 19 646622 9077 109933581
Stenotrophomonas infection 14.62 11.06 8 646633 5850 109936808
Tongue oedema 14.61 11.06 16 646625 8240 109934418
Posterior reversible encephalopathy syndrome 14.60 11.06 127 646514 33734 109908924
Blood sodium increased 14.59 11.06 7 646634 5516 109937142
Ocular discomfort 14.59 11.06 17 646624 8516 109934142
Urticarial vasculitis 14.59 11.06 23 646618 963 109941695
Urinary tract obstruction 14.56 11.06 6 646635 5171 109937487
Dermatitis contact 14.55 11.06 38 646603 13915 109928743
High grade B-cell lymphoma Burkitt-like lymphoma recurrent 14.55 11.06 8 646633 79 109942579
External ear disorder 14.55 11.06 8 646633 79 109942579
Abdominal tenderness 14.52 11.06 32 646609 12425 109930233
Intraventricular haemorrhage 14.52 11.06 7 646634 5500 109937158
Adrenocortical insufficiency acute 14.48 11.06 4 646637 4436 109938222
Cardiomyopathy 14.46 11.06 276 646365 33249 109909409
Enthesophyte 14.46 11.06 10 646631 153 109942505
Pain of skin 14.44 11.06 64 646577 19965 109922693
Pseudomonal sepsis 14.44 11.06 19 646622 9027 109933631
Histoplasmosis 14.43 11.06 44 646597 2909 109939749
Catheter site pain 14.42 11.06 10 646631 6436 109936222
Drug-induced liver injury 14.42 11.06 849 645792 119218 109823440
Splenomegaly 14.41 11.06 84 646557 24414 109918244
Hypertrophic cardiomyopathy 14.41 11.06 46 646595 3117 109939541
Gastroenteritis 14.40 11.06 151 646490 38649 109904009
Embedded device 14.40 11.06 3 646638 4030 109938628
Facial operation 14.37 11.06 4 646637 3 109942655
Neutrophil/lymphocyte ratio increased 14.37 11.06 4 646637 3 109942655
Facial pain 14.36 11.06 44 646597 15295 109927363
Haemothorax 14.34 11.06 12 646629 7019 109935639
Potentiating drug interaction 14.33 11.06 29 646612 11614 109931044
Malabsorption 14.33 11.06 10 646631 6415 109936243
Facial paresis 14.33 11.06 9 646632 6104 109936554
Hepatic enzyme 14.28 11.06 64 646577 5099 109937559
Fungaemia 14.21 11.06 9 646632 6077 109936581
Sluggishness 14.14 11.06 14 646627 7553 109935105
Cystic fibrosis 14.11 11.06 5 646636 4726 109937932
Throat irritation 14.10 11.06 224 646417 53328 109889330
Overwork 14.09 11.06 7 646634 55 109942603
Squamous cell carcinoma of the cervix 14.07 11.06 13 646628 307 109942351
Macular oedema 14.07 11.06 12 646629 6954 109935704
Blood pressure fluctuation 14.06 11.06 553 646088 74271 109868387
International normalised ratio abnormal 14.04 11.06 10 646631 6347 109936311
Ossicle disorder 14.00 11.06 6 646635 32 109942626
Mononeuropathy multiplex 13.99 11.06 21 646620 842 109941816
Asthma-chronic obstructive pulmonary disease overlap syndrome 13.99 11.06 10 646631 6334 109936324
Androgenetic alopecia 13.96 11.06 12 646629 257 109942401
Portal hypertension 13.93 11.06 18 646623 8619 109934039
Middle insomnia 13.90 11.06 67 646574 20435 109922223
Psychomotor retardation 13.90 11.06 15 646626 7777 109934881
Hepatic steatosis 13.87 11.06 379 646262 48452 109894206
Lymphoedema 13.85 11.06 43 646598 14886 109927772
Embolism venous 13.84 11.06 6 646635 5017 109937641
Andersen-Tawil syndrome 13.84 11.06 4 646637 4 109942654
Jugular vein thrombosis 13.78 11.06 7 646634 5338 109937320
Diffuse idiopathic skeletal hyperostosis 13.77 11.06 7 646634 58 109942600
Fundoscopy abnormal 13.77 11.06 7 646634 58 109942600
Pneumonia viral 13.77 11.06 112 646529 11045 109931613
Bile duct stone 13.75 11.06 10 646631 6279 109936379
Paralysis 13.73 11.06 46 646595 15554 109927104
Ischaemic hepatitis 13.71 11.06 5 646636 4643 109938015
Formication 13.68 11.06 8 646633 5640 109937018
Poor quality product administered 13.68 11.06 5 646636 4636 109938022
Blood pressure abnormal 13.67 11.06 76 646565 22348 109920310
Extradural abscess 13.61 11.06 34 646607 2000 109940658
Hypoproteinaemia 13.60 11.06 9 646632 5936 109936722
Facial bones fracture 13.60 11.06 6 646635 4965 109937693
Mediastinal cyst 13.57 11.06 7 646634 60 109942598
Device deployment issue 13.56 11.06 4 646637 4249 109938409
Peroneal nerve palsy 13.53 11.06 14 646627 7400 109935258
Lung transplant 13.51 11.06 7 646634 5279 109937379
Blood blister 13.51 11.06 3 646638 3856 109938802
Therapeutic reaction time decreased 13.48 11.06 7 646634 5272 109937386
Myoglobin blood increased 13.46 11.06 4 646637 4228 109938430
Bronchopleural fistula 13.45 11.06 21 646620 872 109941786
Sinus node dysfunction 13.45 11.06 20 646621 9027 109933631
Venous thrombosis 13.44 11.06 18 646623 8487 109934171
Liver transplant 13.43 11.06 5 646636 4584 109938074
Bradyarrhythmia 13.43 11.06 6 646635 4928 109937730
Bone marrow disorder 13.41 11.06 4 646637 4219 109938439
Cholestatic liver injury 13.38 11.06 14 646627 7362 109935296
Nephrogenic anaemia 13.38 11.06 5 646636 4572 109938086
Iron deficiency anaemia 13.33 11.06 119 646522 31440 109911218
Catheter site haemorrhage 13.32 11.06 9 646632 5871 109936787
Mouth swelling 13.29 11.06 14 646627 7340 109935318
DNA antibody 13.29 11.06 6 646635 37 109942621
Exposed bone in jaw 13.27 11.06 3 646638 3808 109938850
Viral vasculitis 13.26 11.06 11 646630 224 109942434
Genital abscess 13.25 11.06 12 646629 276 109942382
Atrioventricular block second degree 13.25 11.06 17 646624 8164 109934494
Adenocarcinoma of colon 13.24 11.06 10 646631 6158 109936500
Lip oedema 13.15 11.06 15 646626 7585 109935073
Muscle atrophy 13.15 11.06 37 646604 13217 109929441
Large intestinal stenosis 13.11 11.06 3 646638 3777 109938881
Application site pruritus 13.10 11.06 4 646637 4156 109938502
Bone density increased 13.08 11.06 22 646619 973 109941685
Seasonal allergy 13.06 11.06 65 646576 19657 109923001
Sleep disorder due to a general medical condition 13.06 11.06 220 646421 51892 109890766
N-terminal prohormone brain natriuretic peptide increased 13.04 11.06 10 646631 6111 109936547
Pancreatitis necrotising 13.03 11.06 8 646633 5493 109937165
Symptom masked 13.02 11.06 32 646609 1863 109940795
Paresis 13.01 11.06 6 646635 4838 109937820
Vaginal haematoma 13.00 11.06 9 646632 138 109942520
Blood bicarbonate decreased 12.96 11.06 9 646632 5788 109936870
Cell death 12.94 11.06 9 646632 5782 109936876
Diverticulum intestinal 12.94 11.06 31 646610 11688 109930970
Cutaneous tuberculosis 12.93 11.06 12 646629 285 109942373
Cardiac sarcoidosis 12.93 11.06 13 646628 342 109942316
Visual field defect 12.92 11.06 102 646539 9970 109932688
Autonomic nervous system imbalance 12.89 11.06 9 646632 5771 109936887
Renal cell carcinoma 12.88 11.06 15 646626 7515 109935143
Electrocardiogram ST segment depression 12.86 11.06 8 646633 5453 109937205
Yellow skin 12.82 11.06 4 646637 4098 109938560
Culture urine positive 12.79 11.06 6 646635 4790 109937868
Dactylitis 12.79 11.06 53 646588 4080 109938578
Cranial nerve injury 12.78 11.06 6 646635 41 109942617
Transient hypogammaglobulinaemia of infancy 12.78 11.06 6 646635 41 109942617
Diastolic dysfunction 12.77 11.06 34 646607 12370 109930288
Pyelonephritis acute 12.74 11.06 14 646627 7199 109935459
Tendon disorder 12.73 11.06 88 646553 8249 109934409
Urinary tract infection enterococcal 12.72 11.06 3 646638 3699 109938959
Coronary artery bypass 12.71 11.06 10 646631 6032 109936626
Brain neoplasm 12.70 11.06 11 646630 6326 109936332
Abdominal hernia 12.69 11.06 12 646629 6617 109936041
Left ventricular failure 12.67 11.06 30 646611 11359 109931299
Deafness neurosensory 12.66 11.06 98 646543 9521 109933137
Nocardiosis 12.63 11.06 81 646560 7405 109935253
Retinal depigmentation 12.59 11.06 13 646628 353 109942305
Biopsy heart abnormal 12.59 11.06 4 646637 7 109942651
Product administered at inappropriate site 12.56 11.06 8 646633 5385 109937273
Trismus 12.56 11.06 12 646629 6584 109936074
Ureterolithiasis 12.55 11.06 5 646636 4397 109938261
Fracture 12.54 11.06 89 646552 24699 109917959
Nerve block 12.51 11.06 19 646622 770 109941888
Neutrophilia 12.48 11.06 26 646615 10303 109932355
Aspergillus infection 12.46 11.06 93 646548 25523 109917135
Tracheal dilatation 12.44 11.06 3 646638 0 109942658
Senile pruritus 12.44 11.06 3 646638 0 109942658
Vulvovaginal exfoliation 12.44 11.06 3 646638 0 109942658
Lupus pancreatitis 12.44 11.06 3 646638 0 109942658
Laryngeal pain 12.43 11.06 10 646631 5965 109936693
Swollen joint count decreased 12.39 11.06 13 646628 360 109942298
Respiratory rate decreased 12.37 11.06 11 646630 6247 109936411
Defaecation urgency 12.37 11.06 20 646621 8727 109933931
Blindness transient 12.35 11.06 10 646631 5946 109936712
Homicidal ideation 12.34 11.06 3 646638 3624 109939034
Papulopustular rosacea 12.31 11.06 6 646635 45 109942613
Intestinal dilatation 12.31 11.06 3 646638 3617 109939041
Larynx irritation 12.29 11.06 10 646631 198 109942460
Tetany 12.23 11.06 3 646638 3601 109939057
Optical coherence tomography abnormal 12.21 11.06 9 646632 153 109942505
Aortic valve incompetence 12.16 11.06 29 646612 10952 109931706
Gliosis 12.14 11.06 18 646623 714 109941944
Pruritus allergic 12.13 11.06 29 646612 1659 109940999
Spinal X-ray abnormal 12.09 11.06 5 646636 24 109942634
Negative cardiac inotropic effect 12.09 11.06 5 646636 24 109942634
Lipidosis 12.09 11.06 6 646635 47 109942611
Antinuclear antibody 12.08 11.06 14 646627 434 109942224
Vertigo positional 12.07 11.06 4 646637 3944 109938714
Colitis ulcerative 12.07 11.06 352 646289 77011 109865647
Analgesic drug level increased 12.06 11.06 4 646637 3942 109938716
Atypical pneumonia 12.06 11.06 17 646624 7845 109934813
Heparin-induced thrombocytopenia 12.00 11.06 31 646610 11393 109931265
Lepromatous leprosy 11.99 11.06 8 646633 115 109942543
Menopausal symptoms 11.97 11.06 37 646604 2464 109940194
Actinic keratosis 11.96 11.06 14 646627 6999 109935659
Aortic dissection 11.93 11.06 7 646634 4926 109937732
Spinal cord compression 11.92 11.06 16 646625 7536 109935122
Malignant melanoma in situ 11.92 11.06 3 646638 3539 109939119
Diabetic neuropathy 11.91 11.06 14 646627 6985 109935673
Pneumonia pseudomonal 11.89 11.06 16 646625 7530 109935128
Biliary colic 11.88 11.06 6 646635 4591 109938067
Dyspnoea at rest 11.88 11.06 19 646622 8327 109934331
Streptococcal infection 11.87 11.06 29 646612 10861 109931797
Major depression 11.80 11.06 28 646613 10593 109932065
Product quality issue 11.78 11.06 559 646082 76740 109865918
Hepatitis acute 11.77 11.06 63 646578 18703 109923955
Audiogram abnormal 11.77 11.06 5 646636 26 109942632
Rheumatoid vasculitis 11.77 11.06 16 646625 585 109942073
Paraparesis 11.74 11.06 6 646635 4560 109938098
Epstein-Barr virus infection 11.70 11.06 63 646578 18675 109923983
Bone hypertrophy 11.68 11.06 18 646623 739 109941919
Food poisoning 11.66 11.06 12 646629 6360 109936298
Episcleritis 11.63 11.06 24 646617 1242 109941416
Infected varicose vein 11.62 11.06 5 646636 27 109942631
Monocyte count decreased 11.61 11.06 4 646637 3847 109938811
Concussion 11.60 11.06 32 646609 11506 109931152
Benign mediastinal neoplasm 11.58 11.06 6 646635 52 109942606
Polyomavirus viraemia 11.58 11.06 3 646638 3471 109939187
Vascular pseudoaneurysm 11.55 11.06 5 646636 4185 109938473
Contraindication to medical treatment 11.55 11.06 25 646616 1338 109941320
Cerebellar infarction 11.54 11.06 5 646636 4182 109938476
Microvascular coronary artery disease 11.53 11.06 13 646628 391 109942267
Blood pressure diastolic increased 11.52 11.06 164 646477 18643 109924015
Stridor 11.51 11.06 14 646627 6881 109935777
Systemic mycosis 11.50 11.06 4 646637 3825 109938833
Slow speech 11.45 11.06 3 646638 3445 109939213
Immunosuppressant drug level increased 11.43 11.06 33 646608 11691 109930967
Encephalitis 11.41 11.06 64 646577 18775 109923883
Aspergillosis oral 11.39 11.06 6 646635 54 109942604
Allergy to chemicals 11.38 11.06 44 646597 3281 109939377
Pulmonary infarction 11.37 11.06 5 646636 4146 109938512
Culture tissue specimen positive 11.37 11.06 4 646637 11 109942647
Electrocardiogram U-wave abnormality 11.36 11.06 7 646634 87 109942571
Feeling of despair 11.35 11.06 4 646637 3794 109938864
Human anti-human antibody test 11.35 11.06 13 646628 398 109942260
Splenic infection 11.32 11.06 5 646636 29 109942629
Iridocyclitis 11.31 11.06 9 646632 5399 109937259
Retinal disorder 11.29 11.06 35 646606 2335 109940323
Device use issue 11.28 11.06 4 646637 3780 109938878
Anorectal discomfort 11.26 11.06 5 646636 4121 109938537
Oxygen consumption increased 11.23 11.06 10 646631 5675 109936983
Solid organ transplant rejection 11.20 11.06 6 646635 56 109942602
Infusion site extravasation 11.16 11.06 33 646608 11601 109931057
Intestinal haemorrhage 11.14 11.06 16 646625 7325 109935333
Diabetic foot 11.11 11.06 5 646636 4090 109938568
Lupus encephalitis 11.11 11.06 6 646635 57 109942601
Self-medication 11.11 11.06 12 646629 6220 109936438
Sputum discoloured 11.10 11.06 107 646534 27838 109914820
General physical condition abnormal 11.07 11.06 17 646624 7573 109935085

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC P01BA02 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
ANTIMALARIALS
Aminoquinolines
FDA EPC N0000175482 Antimalarial
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000962 Antimalarials
MeSH PA D000977 Antiparasitic Agents
MeSH PA D000981 Antiprotozoal Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D018501 Antirheumatic Agents
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:33281 antimicrobial agent
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35718 antifungal agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:38068 antimalarial
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:50864 insulin-sensitizing drug
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:149553 anticoronaviral agent
FDA EPC N0000175713 Antirheumatic Agent

Related Drugs by ATC class:

P01BA Aminoquinolines 4 drugs
amodiaquinechloroquineprimaquinetafenoquine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ovale malaria indication 19341001 DOID:12919
Vivax malaria indication 27052006 DOID:12978
Quartan malaria indication 27618009 DOID:14324
Systemic lupus erythematosus indication 55464009 DOID:9074
Falciparum malaria indication 62676009 DOID:14067
Rheumatoid arthritis indication 69896004 DOID:7148
Discoid lupus erythematosus indication 200938002
Plasmodium Malariae Malaria Prevention indication
Plasmodium Ovale Malaria Prevention indication
Malaria Prevention indication
Plasmodium Falciparum Malaria Prevention indication
Vasculitis of the skin off-label use 53312001
Porphyria cutanea tarda off-label use 61860000 DOID:3132
Q fever endocarditis off-label use 95890006
Coronavirus infection off-label use 186747009
Polymorphic light eruption off-label use 238525001
Juvenile rheumatoid arthritis off-label use 410795001
Hypercalcemia associated with Sarcoidosis off-label use
Alcoholism contraindication 7200002
Psoriasis contraindication 9014002 DOID:8893
Visual field defect contraindication 12184005
Retinal disorder contraindication 29555009 DOID:5679
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Neutropenic disorder contraindication 303011007 DOID:1227
Disorder of macula of retina contraindication 312999006
Disorder of eye contraindication 371405004 DOID:5614
Visual impairment contraindication 397540003
Porphyria contraindication 418470004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.51 Basic
pKa2 7.83 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Toll-like receptor 9 Membrane receptor ANTAGONIST IC50 7.10 IUPHAR CHEMBL
Toll-like receptor 7 Membrane receptor ANTAGONIST IC50 5.56 IUPHAR CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 4.14 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Ki 4.81 CHEMBL
Muscarinic acetylcholine receptor M2 GPCR Ki 5.98 DRUG MATRIX
Muscarinic acetylcholine receptor M3 GPCR Ki 5.32 CHEMBL
Muscarinic acetylcholine receptor M4 GPCR Ki 5.26 CHEMBL
Muscarinic acetylcholine receptor M5 GPCR Ki 4.70 CHEMBL
Alpha-2C adrenergic receptor GPCR Ki 4.80 CHEMBL
Hemoglobin subunit alpha Secreted WOMBAT-PK
Alpha-1D adrenergic receptor GPCR Ki 5.63 DRUG MATRIX
Transmembrane protein 97 Enzyme Ki 6 CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 5.19 CHEMBL
Cyclic GMP-AMP synthase Enzyme IC50 4.64 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.90 CHEMBL
Genome polyprotein Polyprotein Ki 4.04 CHEMBL

External reference:

IDSource
4019780 VUID
N0000147871 NUI
D02114 KEGG_DRUG
747-36-4 SECONDARY_CAS_RN
4018253 VANDF
4019780 VANDF
C0020336 UMLSCUI
CHEBI:5801 CHEBI
CHEMBL1535 ChEMBL_ID
CHEMBL1690 ChEMBL_ID
DB01611 DRUGBANK_ID
D006886 MESH_DESCRIPTOR_UI
3652 PUBCHEM_CID
7198 IUPHAR_LIGAND_ID
796 INN_ID
4QWG6N8QKH UNII
153972 RXNORM
15082 MMSL
1645 MMSL
4852 MMSL
d00817 MMSL
002949 NDDF
004906 NDDF
13502005 SNOMEDCT_US
373540008 SNOMEDCT_US
83490000 SNOMEDCT_US
4QWG6N8QKH INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0093-2401 TABLET, FILM COATED 200 mg ORAL ANDA 26 sections
Hydroxychloroquine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8459 TABLET, FILM COATED 200 mg ORAL ANDA 25 sections
HYDROXYCHLOROQUINE SULFATE HUMAN PRESCRIPTION DRUG LABEL 1 0904-7046 TABLET, FILM COATED 200 mg ORAL ANDA 26 sections
Hydroxychloroquine Sulfate Human Prescription Drug Label 1 16571-112 TABLET, FILM COATED 200 mg ORAL ANDA 26 sections
Hydroxychloroquine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16714-110 TABLET, FILM COATED 200 mg ORAL ANDA 26 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16729-485 TABLET 200 mg ORAL ANDA 27 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16729-485 TABLET 200 mg ORAL ANDA 27 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16729-561 TABLET 100 mg ORAL ANDA 27 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16729-561 TABLET 100 mg ORAL ANDA 27 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16729-562 TABLET 300 mg ORAL ANDA 27 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16729-562 TABLET 300 mg ORAL ANDA 27 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16729-563 TABLET 400 mg ORAL ANDA 27 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16729-563 TABLET 400 mg ORAL ANDA 27 sections
HYDROXYCHLOROQUINE SULFATE Human Prescription Drug Label 1 42385-971 TABLET, FILM COATED 200 mg ORAL ANDA 26 sections
HYDROXYCHLOROQUINE SULFATE Human Prescription Drug Label 1 43598-131 TABLET 400 mg ORAL ANDA 26 sections
HYDROXYCHLOROQUINE SULFATE Human Prescription Drug Label 1 43598-131 TABLET 400 mg ORAL ANDA 26 sections
HYDROXYCHLOROQUINE SULFATE Human Prescription Drug Label 1 43598-132 TABLET 300 mg ORAL ANDA 26 sections
HYDROXYCHLOROQUINE SULFATE Human Prescription Drug Label 1 43598-132 TABLET 300 mg ORAL ANDA 26 sections
HYDROXYCHLOROQUINE SULFATE Human Prescription Drug Label 1 43598-133 TABLET 100 mg ORAL ANDA 26 sections
HYDROXYCHLOROQUINE SULFATE Human Prescription Drug Label 1 43598-133 TABLET 100 mg ORAL ANDA 26 sections
HYDROXYCHLOROQUINE SULFATE Human Prescription Drug Label 1 43598-721 TABLET 200 mg ORAL ANDA 26 sections
HYDROXYCHLOROQUINE SULFATE Human Prescription Drug Label 1 43598-721 TABLET 200 mg ORAL ANDA 26 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 50090-2508 TABLET, FILM COATED 200 mg ORAL ANDA 16 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 50090-3432 TABLET 200 mg ORAL NDA AUTHORIZED GENERIC 24 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 50090-4659 TABLET, FILM COATED 200 mg ORAL ANDA 28 sections
HYDROXYCHLOROQUINE SULFATE HUMAN PRESCRIPTION DRUG LABEL 1 50090-5388 TABLET 200 mg ORAL ANDA 9 sections
Hydroxychloroquine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 50090-5573 TABLET, FILM COATED 200 mg ORAL ANDA 26 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 50090-6280 TABLET 200 mg ORAL ANDA 26 sections
Hydroxychloroquine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 50090-6629 TABLET, FILM COATED 200 mg ORAL ANDA 26 sections
Hydroxychloroquine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 50090-7306 TABLET, FILM COATED 200 mg ORAL ANDA 26 sections