hydroxychloroquine ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
quinoline derivatives 1395 118-42-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hydroxychloroquine
  • hydroxychloroquine sulfate
  • oxichloroquine
  • oxychlorochin
  • oxychloroquine
A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970). In March 2020, FDA issued an emergency use authorization (EUA) for hydroxychloroquine and chloroquine in the treatment of COVID-10. EUA was revoked in June 2020. Data from various published randomized, controlled clinical trials and retrospective, cohort studies have not substantiated initial reports of efficacy of 4-aminoquinoline antimalarials for treatment of COVID-19.
  • Molecular weight: 335.88
  • Formula: C18H26ClN3O
  • CLOGP: 4.12
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 48.39
  • ALOGS: -4.11
  • ROTB: 9

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.52 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 200 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 27 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 29.77 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 74 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 700 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 11 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.57 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 850 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
April 18, 1955 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 6984.25 11.14 17339 361456 801994 49424335
Drug intolerance 4788.28 11.14 6967 371828 212137 50014192
Rheumatoid arthritis 3554.86 11.14 5824 372971 196726 50029603
Contraindicated product administered 3320.82 11.14 4787 374008 144171 50082158
Joint swelling 3085.59 11.14 6101 372694 239185 49987144
Synovitis 2878.98 11.14 4062 374733 119803 50106526
Treatment failure 2710.49 11.14 4175 374620 133462 50092867
Therapeutic product effect decreased 1988.28 11.14 3612 375183 132438 50093891
Systemic lupus erythematosus 1956.45 11.14 3655 375140 136967 50089362
Arthropathy 1847.60 11.14 3816 374979 154090 50072239
Pemphigus 1619.33 11.14 3082 375713 117084 50109245
Abdominal discomfort 1488.91 11.14 4451 374344 227190 49999139
Hand deformity 1294.28 11.14 2525 376270 97674 50128655
Glossodynia 1275.97 11.14 2729 376066 112840 50113489
Death 1258.27 11.14 434 378361 324945 49901384
Pain 1246.91 11.14 7985 370810 570918 49655411
Alopecia 1234.30 11.14 4333 374462 240714 49985615
Swelling 1216.99 11.14 3782 375013 197090 50029239
Arthralgia 1101.34 11.14 6301 372494 432401 49793928
C-reactive protein abnormal 955.49 11.14 1109 377686 26700 50199629
Rheumatoid factor positive 880.44 11.14 1441 377354 48418 50177911
Hepatic enzyme increased 836.78 11.14 2593 376202 134787 50091542
Anti-cyclic citrullinated peptide antibody positive 827.36 11.14 1709 377086 68878 50157451
Therapeutic product effect incomplete 816.29 11.14 1987 376808 89528 50136801
Musculoskeletal stiffness 804.76 11.14 2449 376346 126032 50100297
Off label use 773.72 11.14 6125 372670 468301 49758028
Red blood cell sedimentation rate abnormal 762.06 11.14 766 378029 15577 50210752
Acute kidney injury 760.02 11.14 379 378416 227679 49998650
Peripheral swelling 726.32 11.14 3259 375536 202677 50023652
Wound 720.79 11.14 2078 376717 103716 50122613
Completed suicide 689.98 11.14 87 378708 131802 50094527
Condition aggravated 646.83 11.14 4116 374679 292942 49933387
Pericarditis 641.17 11.14 1651 377144 77038 50149291
Anaemia 595.55 11.14 607 378188 251849 49974480
Rash 591.37 11.14 5419 373376 432052 49794277
Constipation 591.36 11.14 327 378468 185381 50040948
Discomfort 562.60 11.14 1938 376857 106442 50119887
Hypersensitivity 558.03 11.14 3122 375673 212039 50014290
Drug hypersensitivity 553.42 11.14 3490 375305 247520 49978809
Red blood cell sedimentation rate increased 546.14 11.14 870 377925 28546 50197783
Dehydration 537.46 11.14 234 378561 152215 50074114
Loss of personal independence in daily activities 535.16 11.14 1435 377360 68615 50157714
Hypotension 517.79 11.14 600 378195 234869 49991460
Product use issue 494.84 11.14 2323 376472 147152 50079177
C-reactive protein increased 487.01 11.14 1341 377454 65133 50161196
Gastrointestinal disorder 480.54 11.14 1678 377117 92778 50133551
Maternal exposure during pregnancy 462.53 11.14 2390 376405 157388 50068941
Infusion related reaction 456.48 11.14 2486 376309 167071 50059258
Febrile neutropenia 455.19 11.14 89 378706 97578 50128751
Infection 449.70 11.14 2512 376283 170442 50055887
Hyponatraemia 449.34 11.14 87 378708 96052 50130277
Malignant neoplasm progression 435.43 11.14 17 378778 68107 50158222
Tremor 415.11 11.14 170 378625 114733 50111596
Muscle injury 411.81 11.14 879 377916 36232 50190097
Seizure 402.75 11.14 189 378606 117685 50108644
Folliculitis 396.63 11.14 895 377900 38330 50187999
Ill-defined disorder 377.14 11.14 1079 377716 53575 50172754
Lower respiratory tract infection 375.83 11.14 1560 377235 93641 50132688
Helicobacter infection 371.28 11.14 1010 377785 48692 50177637
Duodenal ulcer perforation 361.03 11.14 947 377848 44664 50181665
Toxicity to various agents 360.10 11.14 650 378145 211849 50014480
Dyspnoea 359.83 11.14 2513 376282 545095 49681234
Retinal toxicity 358.34 11.14 176 378619 1012 50225317
Irritable bowel syndrome 352.44 11.14 1013 377782 50428 50175901
Somnolence 345.75 11.14 390 378405 154595 50071734
Anxiety 339.44 11.14 502 378293 177104 50049225
Drug interaction 326.34 11.14 624 378171 198997 50027332
Impaired healing 323.52 11.14 1203 377592 68583 50157746
Dizziness 318.41 11.14 1422 377373 344947 49881382
Knee arthroplasty 316.75 11.14 776 378019 35070 50191259
Drug abuse 316.44 11.14 38 378757 59808 50166521
Atrial fibrillation 308.23 11.14 190 378605 101555 50124774
Psoriatic arthropathy 307.62 11.14 911 377884 46121 50180208
Sleep disorder due to general medical condition, insomnia type 297.47 11.14 699 378096 30748 50195581
Bradycardia 297.44 11.14 60 378735 64366 50161963
Pulmonary embolism 293.03 11.14 201 378594 101503 50124826
Rheumatoid nodule 292.39 11.14 416 378379 12319 50214010
Overdose 291.47 11.14 194 378601 99533 50126796
Renal failure 289.98 11.14 224 378571 106409 50119920
Product dose omission issue 288.95 11.14 588 378207 183250 50043079
Fall 284.87 11.14 1414 377381 333518 49892811
Blood iron abnormal 284.31 11.14 220 378575 3106 50223223
Neutropenia 282.88 11.14 418 378377 147547 50078782
Thrombocytopenia 281.74 11.14 324 378471 127349 50098980
Tachycardia 272.00 11.14 209 378586 99554 50126775
Depressed level of consciousness 265.01 11.14 37 378758 51916 50174413
Gastrointestinal haemorrhage 260.68 11.14 111 378684 73210 50153119
Inflammation 259.52 11.14 976 377819 55936 50170393
Multiple sclerosis relapse 257.71 11.14 16 378779 42948 50183381
Impaired work ability 249.79 11.14 401 378394 13239 50213090
Musculoskeletal disorder 249.26 11.14 458 378337 16891 50209438
Coma 248.36 11.14 60 378735 56819 50169510
Mobility decreased 244.38 11.14 1215 377580 78733 50147596
Hip arthroplasty 243.02 11.14 634 378161 29795 50196534
Cardio-respiratory arrest 240.97 11.14 54 378741 53838 50172491
Balance disorder 238.25 11.14 115 378680 70475 50155854
White blood cell count decreased 237.76 11.14 315 378480 116407 50109922
Arthritis 237.39 11.14 1278 377517 85443 50140886
Platelet count decreased 237.30 11.14 242 378553 100484 50125845
Blister 234.63 11.14 1260 377535 84158 50142171
Hyperkalaemia 234.42 11.14 39 378756 48050 50178279
Oedema peripheral 232.53 11.14 524 378271 157437 50068892
Retinopathy 230.97 11.14 179 378616 2533 50223796
Disease progression 228.49 11.14 228 378567 95638 50130691
Sinusitis 226.21 11.14 2107 376688 168451 50057878
Agitation 224.09 11.14 61 378734 53323 50173006
Abdominal pain 223.35 11.14 959 377836 235269 49991060
Cerebrovascular accident 220.18 11.14 230 378565 94450 50131879
Urinary tract infection 220.11 11.14 896 377899 223124 50003205
Neutrophil count decreased 216.37 11.14 41 378754 45985 50180344
Muscle spasms 215.22 11.14 381 378414 125172 50101157
Decreased appetite 213.20 11.14 779 378016 200144 50026185
Cardiac arrest 212.21 11.14 188 378607 83463 50142866
Bone erosion 203.72 11.14 336 378459 11351 50214978
Pulmonary fibrosis 202.19 11.14 516 378279 23921 50202408
Sepsis 199.66 11.14 436 378359 132489 50093840
Diarrhoea 199.41 11.14 3154 375641 585322 49641007
Cognitive disorder 197.69 11.14 44 378751 44079 50182250
Haemoglobin decreased 197.15 11.14 410 378385 126806 50099523
Osteoarthritis 195.21 11.14 1022 377773 67584 50158745
Asthenia 194.90 11.14 1493 377302 317549 49908780
Intentional overdose 194.48 11.14 113 378682 62391 50163938
Suicide attempt 194.23 11.14 72 378723 51660 50174669
Syncope 190.97 11.14 297 378498 102705 50123624
Hallucination 189.03 11.14 57 378738 46600 50179729
Blood glucose increased 187.38 11.14 155 378640 71169 50155160
Grip strength decreased 184.33 11.14 328 378467 11793 50214536
Neoplasm progression 183.86 11.14 8 378787 29149 50197180
Hyperhidrosis 182.43 11.14 241 378554 89185 50137144
Disability 181.95 11.14 336 378459 12439 50213890
Rhabdomyolysis 180.84 11.14 36 378759 38991 50187338
Epistaxis 179.41 11.14 130 378665 63824 50162505
Lactic acidosis 179.25 11.14 20 378775 33335 50192994
Joint range of motion decreased 177.79 11.14 414 378381 18098 50208231
Cardiac failure congestive 177.72 11.14 222 378573 84160 50142169
Respiratory failure 177.69 11.14 254 378541 90927 50135402
Cardiac failure 175.34 11.14 186 378609 75854 50150475
Metabolic acidosis 173.37 11.14 39 378756 38786 50187543
Granuloma skin 168.70 11.14 213 378582 5605 50220724
Blood parathyroid hormone decreased 168.66 11.14 236 378559 6878 50219451
Sedation 167.97 11.14 17 378778 30593 50195736
Dysphagia 167.41 11.14 200 378595 77318 50149011
Device expulsion 166.28 11.14 13 378782 28809 50197520
Panniculitis 164.00 11.14 256 378539 8247 50218082
International normalised ratio increased 163.79 11.14 59 378736 43093 50183236
Fibromyalgia 163.41 11.14 719 378076 44259 50182070
Musculoskeletal pain 161.83 11.14 1009 377786 71168 50155161
Chest pain 161.05 11.14 728 378067 176154 50050175
Tenosynovitis 160.79 11.14 286 378509 10279 50216050
Maculopathy 158.85 11.14 126 378669 1848 50224481
Deep vein thrombosis 158.44 11.14 189 378606 73115 50153214
Deafness transitory 156.14 11.14 120 378675 1676 50224653
Deformity 154.46 11.14 240 378555 7700 50218629
Wrong technique in product usage process 154.19 11.14 114 378681 55396 50170933
Depression 153.51 11.14 676 378119 164747 50061582
Disturbance in attention 152.64 11.14 25 378770 31161 50195168
Intentional product use issue 151.58 11.14 1041 377754 75877 50150452
Paraesthesia 149.78 11.14 434 378361 119809 50106520
Serotonin syndrome 148.82 11.14 9 378786 24704 50201625
Drug tolerance decreased 145.93 11.14 253 378542 8907 50217422
Feeling abnormal 144.88 11.14 469 378326 125023 50101306
Respiratory arrest 144.79 11.14 25 378770 29984 50196345
Hypoglycaemia 143.77 11.14 114 378681 53467 50172862
Pneumonia 143.77 11.14 1982 376813 376419 49849910
Rheumatic fever 143.54 11.14 360 378435 16507 50209822
Shoulder arthroplasty 143.35 11.14 152 378643 3296 50223033
Plasma cell myeloma 142.83 11.14 30 378765 31292 50195037
Therapeutic response decreased 140.87 11.14 713 378082 46518 50179811
Swollen joint count increased 139.97 11.14 330 378465 14543 50211786
Bone pain 139.12 11.14 91 378704 47138 50179191
Myalgia 136.41 11.14 475 378320 123844 50102485
Hypoxia 135.63 11.14 110 378685 51013 50175316
Blood pressure decreased 135.45 11.14 131 378664 55778 50170551
Neuropathy peripheral 135.06 11.14 330 378465 96427 50129902
Pleural effusion 134.34 11.14 253 378542 81201 50145128
Vomiting 133.97 11.14 2537 376258 458221 49768108
Stomatitis 133.21 11.14 1250 377545 100094 50126235
Nasopharyngitis 132.90 11.14 2105 376690 190822 50035507
Lupus nephritis 131.66 11.14 122 378673 2233 50224096
Chest discomfort 130.40 11.14 315 378480 92407 50133922
Joint effusion 129.22 11.14 295 378500 12726 50213603
Dyskinesia 128.46 11.14 26 378769 27835 50198494
Fluid retention 127.03 11.14 115 378680 50534 50175795
Sopor 126.86 11.14 5 378790 19874 50206455
Pancytopenia 126.64 11.14 275 378520 83755 50142574
Finger deformity 126.60 11.14 183 378612 5499 50220830
Encephalopathy 126.40 11.14 47 378748 33664 50192665
Hyperglycaemia 126.38 11.14 57 378738 36348 50189981
Musculoskeletal deformity 125.86 11.14 83 378712 895 50225434
Pneumonia aspiration 125.36 11.14 38 378757 30966 50195363
Drug withdrawal syndrome 125.26 11.14 19 378776 25062 50201267
Joint stiffness 124.47 11.14 503 378292 29805 50196524
Disorientation 122.49 11.14 56 378739 35428 50190901
Liver function test increased 122.42 11.14 446 378349 25160 50201169
Palmar-plantar erythrodysaesthesia syndrome 121.99 11.14 7 378788 20091 50206238
Melaena 121.94 11.14 26 378769 26838 50199491
Unresponsive to stimuli 121.11 11.14 39 378756 30570 50195759
Joint destruction 120.97 11.14 148 378647 3768 50222561
Pulmonary oedema 120.50 11.14 113 378682 48825 50177504
Blood cholesterol increased 119.47 11.14 765 378030 54450 50171879
Hepatic failure 119.39 11.14 46 378749 32237 50194092
Product quality issue 119.15 11.14 41 378754 30817 50195512
Polyarthritis 118.60 11.14 213 378582 7714 50218615
Blood bilirubin increased 117.91 11.14 46 378749 31992 50194337
X-ray abnormal 117.58 11.14 121 378674 2531 50223798
Fatigue 117.53 11.14 6442 372353 701159 49525170
Fine motor skill dysfunction 117.04 11.14 149 378646 3954 50222375
Irritability 116.47 11.14 34 378761 28392 50197937
Suicidal ideation 116.30 11.14 146 378649 55239 50171090
Rectal haemorrhage 115.33 11.14 73 378722 38485 50187844
Haemorrhage 115.24 11.14 138 378657 53303 50173026
Cholelithiasis 114.81 11.14 71 378724 37902 50188427
Vision blurred 114.73 11.14 262 378533 78385 50147944
Cerebral haemorrhage 113.35 11.14 31 378764 27021 50199308
Dysarthria 113.00 11.14 70 378725 37333 50188996
Multiple organ dysfunction syndrome 112.85 11.14 126 378669 50211 50176118
Blood calcium decreased 112.32 11.14 12 378783 20694 50205635
Myocardial infarction 111.81 11.14 320 378475 88707 50137622
Restlessness 110.97 11.14 26 378769 25147 50201182
Mental status changes 110.81 11.14 67 378728 36205 50190124
Hepatic function abnormal 110.62 11.14 53 378742 32628 50193701
Hypokalaemia 109.25 11.14 318 378477 87674 50138655
Flushing 107.15 11.14 212 378583 66803 50159526
Pyrexia 106.85 11.14 2105 376690 378098 49848231
Palpitations 105.74 11.14 358 378437 94148 50132181
Gastrooesophageal reflux disease 105.61 11.14 262 378533 76166 50150163
Vertigo 105.36 11.14 140 378655 51692 50174637
Abnormal behaviour 105.09 11.14 12 378783 19646 50206683
Cough 104.36 11.14 1229 377566 240035 49986294
Metastases to bone 104.13 11.14 8 378787 17987 50208342
Dysgeusia 102.90 11.14 84 378711 38832 50187497
Elbow deformity 102.06 11.14 84 378711 1302 50225027
Emotional distress 100.88 11.14 44 378751 28619 50197710
Colitis 100.84 11.14 84 378711 38445 50187884
Blood alkaline phosphatase increased 100.47 11.14 80 378715 37446 50188883
Osteonecrosis of jaw 99.47 11.14 60 378735 32466 50193863
Accidental overdose 99.39 11.14 14 378781 19519 50206810
Lethargy 98.97 11.14 135 378660 49297 50177032
Generalised tonic-clonic seizure 98.11 11.14 37 378758 26273 50200056
Adverse drug reaction 97.53 11.14 728 378067 54494 50171835
Pulmonary toxicity 97.06 11.14 160 378635 5402 50220927
Spinal stenosis 96.80 11.14 271 378524 13279 50213050
Hypomagnesaemia 96.16 11.14 27 378768 23129 50203200
Hospitalisation 96.14 11.14 230 378565 67707 50158622
Arthrodesis 95.34 11.14 105 378690 2380 50223949
Tuberculin test positive 94.54 11.14 118 378677 3068 50223261
Urinary retention 92.50 11.14 40 378755 26150 50200179
SLE arthritis 92.27 11.14 58 378737 572 50225757
Aphasia 92.25 11.14 49 378746 28445 50197884
Asthma 92.25 11.14 350 378445 88987 50137342
Intentional self-injury 92.23 11.14 29 378766 23083 50203246
Eye disorder 91.79 11.14 329 378466 18410 50207919
Device dislocation 91.58 11.14 24 378771 21522 50204807
Chills 91.52 11.14 392 378403 96295 50130034
Adverse event 91.40 11.14 601 378194 43162 50183167
Full blood count decreased 91.05 11.14 27 378768 22319 50204010
Jaundice 90.77 11.14 42 378753 26387 50199942
Ascites 90.43 11.14 81 378714 35780 50190549
Nausea 89.75 11.14 4343 374452 701055 49525274
Nodule 88.88 11.14 305 378490 16698 50209631
Skin necrosis 88.37 11.14 228 378567 10639 50215690
Metastases to liver 88.15 11.14 21 378774 20083 50206246
Renal phospholipidosis 87.70 11.14 32 378763 72 50226257
Gamma-glutamyltransferase increased 87.34 11.14 57 378738 29566 50196763
Abdominal distension 87.23 11.14 268 378527 72635 50153694
Aggression 86.98 11.14 25 378770 21091 50205238
Haematoma 86.89 11.14 61 378734 30449 50195880
Respiratory distress 86.77 11.14 61 378734 30428 50195901
Bone density decreased 86.61 11.14 229 378566 10846 50215483
Renal impairment 86.43 11.14 284 378511 75377 50150952
Mucosal inflammation 86.19 11.14 104 378691 40038 50186291
Neutropenic sepsis 85.64 11.14 5 378790 14142 50212187
Gastrointestinal pain 84.96 11.14 187 378608 7869 50218460
Body height below normal 84.74 11.14 88 378707 1861 50224468
Drug eruption 84.69 11.14 376 378419 23230 50203099
Adverse reaction 84.62 11.14 194 378601 8392 50217937
Muscle spasticity 84.43 11.14 302 378493 16882 50209447
Epilepsy 84.41 11.14 28 378767 21539 50204790
Lymphocyte count decreased 84.06 11.14 46 378749 26261 50200068
Blood urea increased 83.33 11.14 36 378759 23549 50202780
Physical disability 83.20 11.14 85 378710 1762 50224567
Altered state of consciousness 83.07 11.14 30 378765 21880 50204449
Joint laxity 82.93 11.14 96 378699 2302 50224027
Foot deformity 82.23 11.14 323 378472 18887 50207442
Transient ischaemic attack 82.12 11.14 72 378723 32138 50194191
Oral mucosal exfoliation 81.85 11.14 78 378717 1481 50224848
Diabetic ketoacidosis 81.73 11.14 17 378778 17855 50208474
Breast cancer stage III 81.67 11.14 111 378684 3145 50223184
Ear pain 81.55 11.14 423 378372 27860 50198469
Human antichimeric antibody positive 81.05 11.14 76 378719 1413 50224916
Incorrect dose administered 81.03 11.14 149 378646 48265 50178064
Erythema 81.01 11.14 703 378092 145711 50080618
Hypoaesthesia 80.59 11.14 589 378206 126668 50099661
Osteoporosis 80.58 11.14 594 378201 44285 50182044
Chronic kidney disease 80.24 11.14 108 378687 39663 50186666
Acute myocardial infarction 80.15 11.14 61 378734 29212 50197117
Colitis microscopic 79.99 11.14 161 378634 6359 50219970
Blood potassium decreased 79.02 11.14 96 378699 36849 50189480
Upper gastrointestinal haemorrhage 78.15 11.14 13 378782 16022 50210307
Memory impairment 78.05 11.14 317 378478 79043 50147286
Rheumatoid factor negative 77.41 11.14 51 378744 549 50225780
Surgical failure 76.72 11.14 60 378735 861 50225468
Herpes zoster 76.59 11.14 839 377956 69947 50156382
Bone marrow failure 76.36 11.14 57 378738 27567 50198762
Coronary artery disease 76.33 11.14 66 378729 29660 50196669
Red blood cell sedimentation rate 76.28 11.14 113 378682 3473 50222856
Small intestinal obstruction 76.18 11.14 14 378781 16054 50210275
Pancreatitis 75.99 11.14 126 378669 42488 50183841
Haematochezia 75.80 11.14 113 378682 39769 50186560
Ulcer 75.70 11.14 326 378469 19874 50206455
Seronegative arthritis 75.49 11.14 85 378710 1976 50224353
Swollen tongue 75.44 11.14 62 378733 28568 50197761
Status epilepticus 74.72 11.14 7 378788 13399 50212930
Mouth ulceration 74.58 11.14 410 378385 27614 50198715
Acute respiratory failure 73.79 11.14 64 378731 28718 50197611
Intentional product misuse 73.71 11.14 149 378646 46585 50179744
Pneumonia viral 73.62 11.14 160 378635 6674 50219655
Respiratory depression 73.46 11.14 4 378791 12006 50214323
Circulatory collapse 73.13 11.14 29 378766 19971 50206358
Flatulence 72.54 11.14 68 378727 29390 50196939
Glaucoma 72.28 11.14 270 378525 15416 50210913
Speech disorder 72.26 11.14 96 378699 35452 50190877
Drug level increased 72.01 11.14 27 378768 19241 50207088
Urinary incontinence 71.98 11.14 63 378732 28145 50198184
Dry skin 71.33 11.14 134 378661 43057 50183272
Product administration error 71.31 11.14 29 378766 19670 50206659
Gastritis 71.29 11.14 85 378710 32898 50193431
Accidental exposure to product 71.26 11.14 42 378753 23015 50203314
Pallor 70.65 11.14 43 378752 23156 50203173
Tubulointerstitial nephritis 70.53 11.14 14 378781 15197 50211132
Epicondylitis 70.38 11.14 79 378716 1830 50224499
Withdrawal syndrome 70.32 11.14 22 378773 17568 50208761
Hypervolaemia 69.99 11.14 53 378742 25446 50200883
Dysuria 69.95 11.14 66 378729 28438 50197891
Arrhythmia 69.90 11.14 87 378708 33045 50193284
Wheelchair user 69.83 11.14 130 378665 4842 50221487
Cardiac disorder 69.53 11.14 135 378660 42844 50183485
Product prescribing error 69.41 11.14 35 378760 20926 50205403
Interstitial lung disease 69.37 11.14 655 378140 52521 50173808
Oxygen saturation decreased 69.29 11.14 297 378498 72951 50153378
Spinal column injury 68.89 11.14 76 378719 1726 50224603
Cerebral infarction 68.70 11.14 38 378757 21566 50204763
Chronic obstructive pulmonary disease 68.60 11.14 190 378605 53245 50173084
Sciatica 68.16 11.14 329 378466 21053 50205276
Investigation abnormal 67.77 11.14 64 378731 1201 50225128
Myoclonus 67.76 11.14 13 378782 14457 50211872
Dementia 67.65 11.14 18 378777 15979 50210350
Acute hepatic failure 67.52 11.14 17 378778 15660 50210669
Ischaemic stroke 67.34 11.14 18 378777 15930 50210399
Night sweats 65.86 11.14 454 378341 33120 50193209
Orthostatic hypotension 65.85 11.14 74 378721 29407 50196922
Body temperature increased 65.80 11.14 431 378364 30910 50195419
Disseminated intravascular coagulation 65.75 11.14 23 378772 17112 50209217
Acute myeloid leukaemia 65.59 11.14 16 378779 15058 50211271
Wheezing 65.40 11.14 241 378554 61806 50164523
Device related infection 65.17 11.14 37 378758 20698 50205631
Respiratory disorder 64.94 11.14 428 378367 30759 50195570
Joint injury 64.30 11.14 328 378467 21461 50204868
Creatinine renal clearance decreased 64.15 11.14 7 378788 11874 50214455
Mental disorder 63.91 11.14 43 378752 21948 50204381
Swelling face 63.88 11.14 192 378603 52403 50173926
Enthesopathy 63.81 11.14 156 378639 7037 50219292
Feeling hot 63.53 11.14 123 378672 39079 50187250
Neurotoxicity 63.45 11.14 16 378779 14724 50211605
Inappropriate antidiuretic hormone secretion 63.29 11.14 11 378784 13132 50213197
Blood creatinine increased 63.09 11.14 324 378471 75836 50150493
Muscular weakness 62.95 11.14 434 378361 94579 50131750
Complication associated with device 62.91 11.14 16 378779 14639 50211690
Loose body in joint 62.80 11.14 60 378735 1143 50225186
Blood lactate dehydrogenase increased 62.80 11.14 34 378761 19528 50206801
Onychomycosis 62.45 11.14 125 378670 4917 50221412
Hallucination, visual 62.36 11.14 23 378772 16559 50209770
Muscle twitching 62.23 11.14 19 378776 15412 50210917
Rheumatoid lung 61.77 11.14 84 378711 2381 50223948
Neuroleptic malignant syndrome 61.53 11.14 6 378789 11124 50215205
Haematemesis 61.48 11.14 70 378725 27655 50198674
Fear of injection 61.37 11.14 139 378656 5964 50220365
Inappropriate schedule of product administration 60.97 11.14 303 378492 71528 50154801
Hepatocellular injury 60.32 11.14 63 378732 25884 50200445
Psychotic disorder 60.30 11.14 45 378750 21767 50204562
Weight decreased 59.58 11.14 1233 377562 220012 50006317
Electrolyte imbalance 59.40 11.14 27 378768 17142 50209187
Coordination abnormal 59.31 11.14 8 378787 11526 50214803
Hemiparesis 58.53 11.14 39 378756 20009 50206320
Injection site pain 58.36 11.14 540 378255 110484 50115845
Dislocation of vertebra 58.23 11.14 92 378703 2995 50223334
Clostridium difficile colitis 58.19 11.14 30 378765 17712 50208617
Vascular access complication 58.06 11.14 56 378739 1080 50225249
Metastases to central nervous system 57.60 11.14 8 378787 11274 50215055
Depressed mood 57.56 11.14 104 378691 33919 50192410
Mania 57.52 11.14 7 378788 10909 50215420
Cyanosis 57.21 11.14 21 378774 15163 50211166
Diabetes mellitus inadequate control 57.11 11.14 14 378781 13131 50213198
Wrist deformity 56.90 11.14 69 378726 1740 50224589
Delirium 56.68 11.14 126 378669 38066 50188263
Sleep apnoea syndrome 56.56 11.14 57 378738 23811 50202518
Head injury 56.20 11.14 58 378737 23962 50202367
Sleep disorder 56.12 11.14 666 378129 56617 50169712
Paranoia 56.12 11.14 6 378789 10342 50215987
Viral upper respiratory tract infection 56.08 11.14 146 378649 6850 50219479
Red cell distribution width decreased 55.59 11.14 54 378741 1051 50225278
Blood triglycerides increased 55.51 11.14 9 378786 11303 50215026
Cellulitis 55.41 11.14 307 378488 70491 50155838
Obstructive airways disorder 55.12 11.14 24 378771 15628 50210701
Back injury 54.90 11.14 146 378649 6939 50219390
Full blood count abnormal 54.12 11.14 57 378738 23331 50202998
Abortion spontaneous 54.02 11.14 148 378647 41624 50184705
Mental impairment 53.96 11.14 12 378783 12032 50214297
Parkinsonism 53.95 11.14 3 378792 8844 50217485
Nervous system disorder 53.85 11.14 27 378768 16196 50210133
Haematuria 53.26 11.14 68 378727 25545 50200784
Basal cell carcinoma 53.24 11.14 328 378467 23028 50203301
Heart rate increased 53.09 11.14 349 378446 76901 50149428
Multiple fractures 53.03 11.14 138 378657 6473 50219856
Back pain 52.44 11.14 1250 377545 218780 50007549
Type 2 diabetes mellitus 52.34 11.14 438 378357 33937 50192392
Underdose 50.89 11.14 46 378749 20232 50206097
Blood creatine phosphokinase increased 50.79 11.14 74 378721 26293 50200036
Anuria 50.79 11.14 11 378784 11233 50215096
Blood sodium decreased 50.69 11.14 50 378745 21097 50205232
Thrombosis 50.61 11.14 230 378565 55603 50170726
Abdominal pain lower 50.37 11.14 53 378742 21703 50204626
Subacute cutaneous lupus erythematosus 50.31 11.14 72 378723 2143 50224186
Extrapyramidal disorder 50.23 11.14 13 378782 11757 50214572
Cholestasis 50.21 11.14 70 378725 25331 50200998
Vaginal haemorrhage 50.20 11.14 66 378729 24485 50201844
Product label confusion 50.15 11.14 37 378758 484 50225845
Hypothermia 49.91 11.14 14 378781 12002 50214327
Coagulopathy 49.63 11.14 37 378758 17907 50208422
Akathisia 49.54 11.14 3 378792 8226 50218103
Anger 49.37 11.14 12 378783 11321 50215008
Device issue 49.29 11.14 46 378749 19926 50206403
Infusion site reaction 49.07 11.14 71 378724 2135 50224194
Mean platelet volume decreased 49.02 11.14 61 378734 1581 50224748
Therapy non-responder 48.58 11.14 590 378205 50432 50175897
Multiple sclerosis 48.49 11.14 49 378746 20444 50205885
Pulmonary congestion 48.22 11.14 27 378768 15220 50211109
Alanine aminotransferase increased 48.07 11.14 426 378369 87933 50138396
Foot operation 47.29 11.14 118 378677 5392 50220937
Tachypnoea 47.29 11.14 25 378770 14552 50211777
Blood glucose decreased 47.28 11.14 40 378755 18171 50208158
Poisoning deliberate 47.28 11.14 3 378792 7909 50218420
Cytomegalovirus infection 47.20 11.14 39 378756 17923 50208406
Poisoning 47.15 11.14 17 378778 12412 50213917
Mydriasis 46.79 11.14 11 378784 10616 50215713
Pulmonary hypertension 46.58 11.14 114 378681 33303 50193026
Ocular toxicity 46.47 11.14 36 378759 509 50225820
Blood magnesium decreased 46.36 11.14 13 378782 11147 50215182
Confusional state 46.32 11.14 1049 377746 184879 50041450
Device difficult to use 46.04 11.14 9 378786 9877 50216452
Nightmare 46.01 11.14 32 378763 16054 50210275
Leukocytosis 45.86 11.14 61 378734 22518 50203811
Renal tubular necrosis 45.82 11.14 10 378785 10158 50216171
Ankle arthroplasty 45.04 11.14 49 378746 1095 50225234
Incontinence 44.63 11.14 10 378785 9975 50216354
Bone density abnormal 44.51 11.14 81 378714 2964 50223365
Infective pulmonary exacerbation of cystic fibrosis 44.43 11.14 4 378791 7905 50218424
Renal disorder 43.96 11.14 87 378708 27418 50198911
Hyperthyroidism 43.95 11.14 18 378777 12157 50214172
Ileus 43.94 11.14 22 378773 13207 50213122
Antibody test positive 43.76 11.14 69 378726 2242 50224087
Metastases to lung 43.66 11.14 14 378781 11006 50215323
Muscle rigidity 43.62 11.14 10 378785 9819 50216510
Neck pain 43.18 11.14 633 378162 56434 50169895
Hypersomnia 43.10 11.14 31 378764 15283 50211046
Onychomadesis 43 11.14 87 378708 3449 50222880
Hypophosphataemia 42.88 11.14 6 378789 8408 50217921
Heart rate irregular 42.80 11.14 49 378746 19311 50207018
Skin exfoliation 42.78 11.14 120 378675 33492 50192837
Feeling cold 42.56 11.14 50 378745 19481 50206848
Blood albumin decreased 42.49 11.14 23 378772 13213 50213116
Transfusion 42.06 11.14 22 378773 12883 50213446
Haemorrhage intracranial 41.97 11.14 20 378775 12354 50213975
Intestinal obstruction 41.70 11.14 84 378711 26299 50200030
Pleural thickening 41.68 11.14 72 378723 2527 50223802
Ovarian neoplasm 41.67 11.14 41 378754 811 50225518
Anal incontinence 41.45 11.14 17 378778 11473 50214856
Hot flush 41.21 11.14 180 378615 43989 50182340
Mycotic allergy 41.16 11.14 40 378755 779 50225550
Glycosylated haemoglobin increased 41.10 11.14 14 378781 10592 50215737
Paraesthesia oral 41.08 11.14 20 378775 12201 50214128
Malnutrition 40.79 11.14 24 378771 13165 50213164
Transaminases abnormal 40.53 11.14 34 378761 542 50225787
Brain oedema 40.44 11.14 21 378774 12349 50213980
Phospholipidosis 40.38 11.14 16 378779 49 50226280
Aspartate aminotransferase increased 40.27 11.14 381 378414 77617 50148712
Osteoporotic fracture 40.19 11.14 79 378716 3066 50223263
Shock haemorrhagic 40.14 11.14 7 378788 8337 50217992
Oedema 40.11 11.14 334 378461 69847 50156482
Loss of consciousness 40.02 11.14 545 378250 103808 50122521
Ataxia 40 11.14 27 378768 13759 50212570
Aspiration 39.98 11.14 10 378785 9254 50217075
Myelosuppression 39.86 11.14 26 378769 13491 50212838
Presbyacusis 39.51 11.14 73 378722 2703 50223626
Bone swelling 39.45 11.14 47 378748 1163 50225166
Subdural haematoma 39.42 11.14 24 378771 12923 50213406
Pollakiuria 39.37 11.14 74 378721 23777 50202552
Sinus bradycardia 39.36 11.14 25 378770 13158 50213171
Dialysis 39.19 11.14 11 378784 9427 50216902
Cholecystitis 39.14 11.14 28 378767 13843 50212486
Sinus tachycardia 39.14 11.14 62 378733 21292 50205037
Cutaneous vasculitis 39.12 11.14 95 378700 4267 50222062
Haemoptysis 39.08 11.14 83 378712 25490 50200839
Amnesia 38.95 11.14 173 378622 42087 50184242
Amenorrhoea 38.94 11.14 8 378787 8476 50217853
Dyspnoea exertional 38.55 11.14 225 378570 51008 50175321
Mean cell volume decreased 38.51 11.14 70 378725 2559 50223770
Therapy cessation 38.44 11.14 86 378709 25925 50200404
Mood altered 38.44 11.14 24 378771 12749 50213580
Eye swelling 38.35 11.14 57 378738 20087 50206242
Hypoalbuminaemia 38.24 11.14 13 378782 9847 50216482
Pulmonary arterial hypertension 38.19 11.14 58 378737 20261 50206068
Contusion 38.17 11.14 1105 377690 111078 50115251
Laryngeal disorder 38.14 11.14 40 378755 856 50225473
Lip swelling 38.04 11.14 80 378715 24656 50201673
Nervousness 38.01 11.14 95 378700 27556 50198773
Angioedema 37.98 11.14 149 378646 37527 50188802
Blood pressure increased 37.88 11.14 735 378060 132397 50093932
Neck mass 37.71 11.14 80 378715 3281 50223048
Angina pectoris 37.56 11.14 88 378707 26100 50200229
Lipase increased 37.29 11.14 9 378786 8532 50217797
Haematotoxicity 37.17 11.14 7 378788 7888 50218441
Sensitivity to weather change 37.10 11.14 114 378681 5887 50220442
Lupus vasculitis 36.88 11.14 30 378765 457 50225872
International normalised ratio fluctuation 36.87 11.14 62 378733 2128 50224201
Pericardial effusion 36.69 11.14 86 378709 25503 50200826
Skin discolouration 36.68 11.14 124 378671 32633 50193696
Urine output decreased 36.66 11.14 16 378779 10405 50215924
Psychomotor hyperactivity 36.53 11.14 12 378783 9289 50217040
Acquired pigmented retinopathy 36.42 11.14 10 378785 3 50226326
Synovial cyst 36.33 11.14 139 378656 8027 50218302
Retching 36.25 11.14 26 378769 12836 50213493
Pleural fibrosis 36.19 11.14 79 378716 3305 50223024
Diplopia 36.18 11.14 55 378740 19205 50207124
Delusion 35.98 11.14 17 378778 10552 50215777
Supraventricular tachycardia 35.91 11.14 26 378769 12775 50213554
Aplastic anaemia 35.90 11.14 7 378788 7696 50218633
Drug resistance 35.89 11.14 54 378741 18935 50207394
Hip fracture 35.72 11.14 89 378706 25842 50200487
Pharyngitis 35.71 11.14 239 378556 17264 50209065
Subarachnoid haemorrhage 35.67 11.14 18 378777 10758 50215571
Injection site reaction 35.53 11.14 549 378246 49483 50176846
Acidosis 35.51 11.14 16 378779 10211 50216118
Overlap syndrome 35.39 11.14 33 378762 609 50225720
Cholecystitis chronic 35.38 11.14 14 378781 9655 50216674
Bronchitis chronic 35.37 11.14 85 378710 3792 50222537
Clostridium difficile infection 35.28 11.14 87 378708 25352 50200977
Retinitis 35.26 11.14 56 378739 1831 50224498
Acute coronary syndrome 35.25 11.14 13 378782 9361 50216968
Staphylococcal infection 35.17 11.14 142 378653 35474 50190855
Extremity contracture 35.09 11.14 45 378750 1203 50225126
Restrictive cardiomyopathy 35.03 11.14 24 378771 277 50226052
Pancreatitis acute 34.97 11.14 79 378716 23733 50202596
Injection site erythema 34.97 11.14 375 378420 74561 50151768
Graft versus host disease 34.96 11.14 3 378792 6163 50220166
Glomerular filtration rate decreased 34.92 11.14 22 378773 11630 50214699
Soft tissue disorder 34.87 11.14 89 378706 4125 50222204
Hypocalcaemia 34.68 11.14 95 378700 26721 50199608
Ageusia 34.54 11.14 22 378773 11561 50214768
Large intestine perforation 34.53 11.14 7 378788 7487 50218842
Frequent bowel movements 34.42 11.14 32 378763 13886 50212443
Ear infection 34.41 11.14 321 378474 25649 50200680
Faeces discoloured 34.37 11.14 42 378753 16082 50210247
Haemodialysis 34.26 11.14 10 378785 8352 50217977
Faecaloma 34.11 11.14 6 378789 7102 50219227
Taste disorder 34.02 11.14 10 378785 8314 50218015
Hallucination, auditory 33.92 11.14 19 378776 10709 50215620
Drug specific antibody 33.88 11.14 54 378741 1771 50224558
Panic attack 33.73 11.14 58 378737 19284 50207045
Abnormal dreams 33.62 11.14 14 378781 9363 50216966
Hepatic encephalopathy 33.58 11.14 15 378780 9621 50216708
Metastases to lymph nodes 33.56 11.14 6 378789 7018 50219311
Thrombotic microangiopathy 33.39 11.14 12 378783 8779 50217550
Breast cancer metastatic 33.29 11.14 18 378777 10346 50215983
Shock 33.28 11.14 65 378730 20585 50205744
Right ventricular failure 33.24 11.14 42 378753 15851 50210478
Sensory disturbance 33.22 11.14 24 378771 11805 50214524
Caesarean section 33.06 11.14 41 378754 15598 50210731
Myopathy toxic 32.68 11.14 26 378769 383 50225946
Presyncope 32.60 11.14 84 378711 24114 50202215
Dystonia 32.46 11.14 25 378770 11901 50214428
Hypoacusis 32.40 11.14 66 378729 20581 50205748
Deafness neurosensory 32.13 11.14 90 378705 4411 50221918
Polyuria 32.10 11.14 7 378788 7114 50219215
Infiltration anaesthesia 32.08 11.14 18 378777 141 50226188
Medication error 31.96 11.14 150 378645 35954 50190375
Cardiogenic shock 31.83 11.14 42 378753 15557 50210772
Hair follicle tumour benign 31.78 11.14 25 378770 362 50225967
Live birth 31.66 11.14 221 378574 16187 50210142
Face oedema 31.57 11.14 53 378742 17786 50208543
Upper respiratory tract infection 31.47 11.14 328 378467 65570 50160759
Brain injury 31.34 11.14 4 378791 6010 50220319
Rash erythematous 31.33 11.14 144 378651 34708 50191621
Stress cardiomyopathy 31.28 11.14 10 378785 7877 50218452
White blood cell count increased 30.99 11.14 187 378608 42053 50184276
Rash macular 30.78 11.14 61 378734 19216 50207113
Fracture 30.73 11.14 49 378746 16784 50209545
Lymphoedema 30.55 11.14 15 378780 9107 50217222
Enterocolitis 30.54 11.14 6 378789 6561 50219768
Joint arthroplasty 30.43 11.14 56 378739 2067 50224262
Prothrombin time prolonged 30.42 11.14 14 378781 8824 50217505
Eosinophil count increased 30.37 11.14 14 378781 8816 50217513
Bacteraemia 30.34 11.14 38 378757 14395 50211934
Accident 30.25 11.14 96 378699 5045 50221284
Mesenteritis 30.21 11.14 17 378778 134 50226195
Drug reaction with eosinophilia and systemic symptoms 30.21 11.14 110 378685 28314 50198015
Intermenstrual bleeding 30.11 11.14 7 378788 6807 50219522
Ejection fraction decreased 30.10 11.14 58 378737 18462 50207867
Hypothyroidism 30.08 11.14 142 378653 33983 50192346
Cholecystitis acute 30.04 11.14 8 378787 7098 50219231
Agranulocytosis 29.91 11.14 73 378722 21348 50204981
Labelled drug-drug interaction medication error 29.76 11.14 21 378774 10456 50215873
Colitis ischaemic 29.69 11.14 17 378778 9466 50216863
Myelodysplastic syndrome 29.61 11.14 42 378753 15090 50211239
Myocardial ischaemia 29.55 11.14 26 378769 11587 50214742
Influenza like illness 29.52 11.14 281 378514 57178 50169151
Petechiae 29.51 11.14 30 378765 12482 50213847
Histoplasmosis disseminated 29.50 11.14 42 378753 1244 50225085
Anti-cyclic citrullinated peptide antibody 29.41 11.14 47 378748 1545 50224784
Bloody discharge 29.41 11.14 40 378755 1134 50225195
Coeliac disease 29.40 11.14 136 378659 8549 50217780
Neck deformity 29.40 11.14 53 378742 1925 50224404
Wrist surgery 29.38 11.14 33 378762 765 50225564
Suspected suicide 29.32 11.14 3 378792 5354 50220975
Premature labour 28.83 11.14 26 378769 11450 50214879
Arteriosclerosis 28.81 11.14 16 378779 9061 50217268
Vasculitic rash 28.81 11.14 41 378754 1214 50225115
Salivary hypersecretion 28.67 11.14 7 378788 6584 50219745
Heavy menstrual bleeding 28.58 11.14 45 378750 15492 50210837
Anovulatory cycle 28.55 11.14 16 378779 125 50226204
Incorrect product administration duration 28.51 11.14 17 378778 9258 50217071
Central nervous system lesion 28.32 11.14 18 378777 9471 50216858
Hypovolaemia 28.19 11.14 18 378777 9447 50216882
Stevens-Johnson syndrome 28.17 11.14 77 378718 21675 50204654
Large intestine polyp 27.86 11.14 10 378785 7322 50219007
Bradyphrenia 27.82 11.14 6 378789 6146 50220183
Metabolic encephalopathy 27.69 11.14 3 378792 5118 50221211
Hyperreflexia 27.67 11.14 3 378792 5115 50221214
Hiatus hernia 27.64 11.14 60 378735 18284 50208045
Infusion site pain 27.56 11.14 31 378764 12315 50214014
Electrocardiogram U-wave abnormality 27.56 11.14 10 378785 22 50226307
Post procedural haemorrhage 27.48 11.14 10 378785 7260 50219069
Acute pulmonary oedema 27.46 11.14 10 378785 7257 50219072
Activated partial thromboplastin time prolonged 27.46 11.14 7 378788 6395 50219934
Hospice care 27.43 11.14 5 378790 5767 50220562
Injection site mass 27.36 11.14 47 378748 15633 50210696
Asphyxia 27.35 11.14 4 378791 5423 50220906
Hypoaesthesia oral 27.32 11.14 24 378771 10704 50215625
Mean cell haemoglobin decreased 27.30 11.14 70 378725 3253 50223076
Blood magnesium increased 27.20 11.14 64 378731 2816 50223513
Anhedonia 27.17 11.14 19 378776 9505 50216824
Diverticulitis 27.07 11.14 373 378422 32809 50193520
Visual acuity reduced 27.06 11.14 70 378725 20069 50206260
Eyelid oedema 26.85 11.14 19 378776 9447 50216882
Infusion site erythema 26.82 11.14 16 378779 8711 50217618
Optical coherence tomography abnormal 26.78 11.14 9 378786 14 50226315
Pathological fracture 26.70 11.14 12 378783 7670 50218659
Device malfunction 26.69 11.14 45 378750 15076 50211253
Diarrhoea haemorrhagic 26.66 11.14 12 378783 7663 50218666
Laboratory test abnormal 26.57 11.14 87 378708 23121 50203208
Throat irritation 26.55 11.14 126 378669 30113 50196216
Eye pain 26.50 11.14 116 378679 28333 50197996
Pemphigoid 26.23 11.14 6 378789 5901 50220428
Hyperbilirubinaemia 26.12 11.14 20 378775 9550 50216779
Throat tightness 26.11 11.14 75 378720 20772 50205557
Long QT syndrome 25.95 11.14 64 378731 2903 50223426
Gingivitis 25.92 11.14 11 378784 7273 50219056
Needle issue 25.86 11.14 11 378784 7264 50219065
Mycobacterium tuberculosis complex test positive 25.84 11.14 47 378748 1719 50224610
Alanine aminotransferase abnormal 25.74 11.14 79 378716 4077 50222252
Cold sweat 25.70 11.14 25 378770 10619 50215710
Disease susceptibility 25.42 11.14 17 378778 188 50226141
Tenderness 25.37 11.14 231 378564 18334 50207995
Cutaneous coccidioidomycosis 25.37 11.14 9 378786 18 50226311
Oesophagitis 25.35 11.14 38 378757 13345 50212984
Oliguria 25.34 11.14 15 378780 8201 50218128
Eye pruritus 25.32 11.14 34 378761 12500 50213829
Skin ulcer 25.25 11.14 388 378407 34930 50191399
Jaundice cholestatic 25.23 11.14 4 378791 5107 50221222
Ankle operation 25.15 11.14 38 378757 1189 50225140
Lower gastrointestinal haemorrhage 25.11 11.14 10 378785 6869 50219460
Transplant rejection 25.08 11.14 21 378774 9588 50216741
Crohn's disease 25.02 11.14 3 378792 4730 50221599
Hemiplegia 24.93 11.14 12 378783 7369 50218960
Pulseless electrical activity 24.88 11.14 10 378785 6831 50219498
Hypotonia 24.87 11.14 15 378780 8119 50218210
Renal injury 24.80 11.14 17 378778 8594 50217735
Troponin increased 24.78 11.14 15 378780 8103 50218226
Stress at work 24.75 11.14 35 378760 1030 50225299
Device breakage 24.75 11.14 21 378774 9526 50216803
Hepatic cytolysis 24.70 11.14 15 378780 8088 50218241
Oral discomfort 24.58 11.14 122 378673 7895 50218434
Proctalgia 24.50 11.14 4 378791 4999 50221330
Skin burning sensation 24.50 11.14 24 378771 10161 50216168
Pancreatic carcinoma 24.43 11.14 8 378787 6206 50220123
Diverticulum 24.41 11.14 26 378769 10588 50215741
Apathy 24.40 11.14 13 378782 7535 50218794
Burning sensation 24.31 11.14 220 378575 45226 50181103
Haemodynamic instability 24.26 11.14 15 378780 8009 50218320
Intestinal sepsis 24.24 11.14 18 378777 238 50226091
Device leakage 24.13 11.14 7 378788 5871 50220458
Unintended pregnancy 24.12 11.14 4 378791 4942 50221387
Device use error 24.10 11.14 5 378790 5261 50221068
Lupus-like syndrome 24.02 11.14 137 378658 9354 50216975
Fistula 23.97 11.14 16 378779 8202 50218127
Thyroid neoplasm 23.94 11.14 69 378726 3438 50222891
Muscle tightness 23.85 11.14 25 378770 10255 50216074
Klebsiella infection 23.84 11.14 12 378783 7182 50219147
Lupus myocarditis 23.79 11.14 11 378784 54 50226275
Limb operation 23.75 11.14 67 378728 3297 50223032
Toxic encephalopathy 23.71 11.14 6 378789 5509 50220820
Application site erythema 23.69 11.14 3 378792 4535 50221794
Pulmonary mass 23.69 11.14 229 378566 18476 50207853
Bone cyst 23.67 11.14 49 378746 1975 50224354
Failure to thrive 23.61 11.14 9 378786 6349 50219980
Bone disorder 23.47 11.14 229 378566 18523 50207806
Chromaturia 23.44 11.14 46 378749 14544 50211785
Mass excision 23.44 11.14 18 378777 251 50226078
Hypertensive crisis 23.35 11.14 39 378756 13115 50213214
Cartilage atrophy 23.28 11.14 15 378780 155 50226174
Device occlusion 23.25 11.14 8 378787 6015 50220314
White blood cell count abnormal 23.23 11.14 6 378789 5434 50220895
Tuberculosis 23.23 11.14 142 378653 9941 50216388
Malaise 23.21 11.14 2179 376616 333353 49892976
Dry mouth 23.15 11.14 289 378506 55889 50170440
Hypercalcaemia 23.08 11.14 272 378523 23080 50203249
COVID-19 treatment 23.05 11.14 13 378782 103 50226226
Sudden death 23.04 11.14 20 378775 8971 50217358
Hyperventilation 23.03 11.14 6 378789 5403 50220926
Drug level decreased 23.03 11.14 10 378785 6523 50219806
Retinal degeneration 22.88 11.14 28 378767 713 50225616
Lacrimation increased 22.88 11.14 59 378736 16933 50209396
Product substitution issue 22.86 11.14 44 378751 14013 50212316
Cystitis 22.86 11.14 218 378577 44346 50181983
Pain in extremity 22.62 11.14 2353 376442 270512 49955817
Blood calcium increased 22.55 11.14 15 378780 7704 50218625
Thinking abnormal 22.49 11.14 23 378772 9544 50216785
Fear 22.41 11.14 47 378748 14502 50211827
Influenza 22.32 11.14 505 378290 89033 50137296
Dysphonia 22.26 11.14 185 378610 38707 50187622
Pustular psoriasis 22.21 11.14 73 378722 3908 50222421
Migraine 22.20 11.14 413 378382 74867 50151462
Diabetic eye disease 22.11 11.14 14 378781 140 50226189
Haemorrhoids 22.10 11.14 71 378724 18982 50207347
Arteriosclerosis coronary artery 22.09 11.14 15 378780 7621 50218708
Hepatic necrosis 22.01 11.14 6 378789 5242 50221087
Blood thyroid stimulating hormone increased 22.00 11.14 9 378786 6083 50220246
Nail disorder 21.91 11.14 136 378659 9572 50216757
Chorioretinitis 21.89 11.14 22 378773 447 50225882
Hydronephrosis 21.88 11.14 19 378776 8522 50217807
Venoocclusive liver disease 21.81 11.14 3 378792 4258 50222071
Escherichia infection 21.77 11.14 30 378765 10911 50215418
Cushingoid 21.72 11.14 103 378692 6542 50219787
Infective exacerbation of bronchiectasis 21.69 11.14 19 378776 322 50226007
Fundoscopy abnormal 21.60 11.14 7 378788 9 50226320
Body tinea 21.59 11.14 37 378758 1290 50225039
Polyneuropathy 21.50 11.14 36 378759 12095 50214234
Thirst 21.40 11.14 29 378766 10621 50215708
Musculoskeletal chest pain 21.37 11.14 69 378726 18417 50207912
Femoral neck fracture 21.29 11.14 15 378780 7475 50218854
Sinus disorder 21.26 11.14 69 378726 18389 50207940
Ankylosing spondylitis 21.23 11.14 108 378687 7057 50219272
Femur fracture 21.10 11.14 396 378399 37068 50189261
Pelvic pain 21.08 11.14 32 378763 11181 50215148
Blood glucose fluctuation 21.03 11.14 3 378792 4143 50222186
Product storage error 21.00 11.14 37 378758 12187 50214142
Coma scale abnormal 20.88 11.14 5 378790 4766 50221563
Synovial fluid analysis 20.76 11.14 41 378754 1597 50224732
Liver injury 20.71 11.14 280 378515 24526 50201803
Foetal exposure during pregnancy 20.66 11.14 120 378675 27239 50199090
Major depression 20.63 11.14 13 378782 6871 50219458
Pregnancy with contraceptive device 20.57 11.14 3 378792 4076 50222253
Seasonal allergy 20.50 11.14 50 378745 14626 50211703
Product adhesion issue 20.45 11.14 4 378791 4388 50221941
Bronchospasm 20.44 11.14 51 378744 14803 50211526
Motor dysfunction 20.41 11.14 18 378777 8013 50218316
Peripheral sensory neuropathy 20.37 11.14 12 378783 6579 50219750
Sneezing 20.29 11.14 47 378748 13997 50212332
Hepatotoxicity 20.20 11.14 301 378494 26925 50199404
Head discomfort 20.19 11.14 32 378763 10987 50215342
Neutrophil count increased 20.12 11.14 48 378747 14147 50212182
Therapy interrupted 20.11 11.14 80 378715 20072 50206257
Juvenile idiopathic arthritis 19.99 11.14 57 378738 2822 50223507
Somnambulism 19.97 11.14 6 378789 4918 50221411
Hypercapnia 19.96 11.14 5 378790 4622 50221707
Peritonitis 19.92 11.14 55 378740 15431 50210898
Salt craving 19.84 11.14 11 378784 84 50226245
Ischaemia 19.83 11.14 4 378791 4293 50222036
Dyslipidaemia 19.82 11.14 10 378785 5978 50220351
Bronchopleural fistula 19.73 11.14 15 378780 206 50226123
Bradykinesia 19.66 11.14 3 378792 3940 50222389
Extradural abscess 19.55 11.14 27 378768 777 50225552
Limb deformity 19.53 11.14 67 378728 3667 50222662
Spinal fracture 19.52 11.14 56 378739 15517 50210812
Butterfly rash 19.51 11.14 34 378761 1202 50225127
Cardiomegaly 19.50 11.14 58 378737 15887 50210442
Skin toxicity 19.46 11.14 3 378792 3910 50222419
Drug effective for unapproved indication 19.36 11.14 45 378750 1964 50224365
Menstruation irregular 19.36 11.14 11 378784 6151 50220178
Adrenal insufficiency 19.35 11.14 177 378618 14066 50212263
Blood urine present 19.32 11.14 42 378753 12791 50213538
Respiration abnormal 19.32 11.14 7 378788 5095 50221234
Fungal infection 19.28 11.14 138 378657 29827 50196502
Post transplant lymphoproliferative disorder 19.22 11.14 4 378791 4200 50222129
Lung infiltration 19.21 11.14 45 378750 13348 50212981
Diffuse alopecia 19.18 11.14 23 378772 573 50225756
Wound infection 19.14 11.14 156 378639 11992 50214337
Functional gastrointestinal disorder 19.10 11.14 63 378732 3379 50222950
Dermatitis contact 18.98 11.14 22 378773 8624 50217705
Infective tenosynovitis 18.91 11.14 15 378780 220 50226109
Lung disorder 18.90 11.14 454 378341 44345 50181984
Sensory loss 18.89 11.14 18 378777 7720 50218609
Myocarditis 18.80 11.14 19 378776 7928 50218401
Aplasia 18.78 11.14 3 378792 3810 50222519
Metabolic disorder 18.78 11.14 8 378787 5278 50221051
Hepatic enzyme abnormal 18.74 11.14 79 378716 4770 50221559
Application site pain 18.68 11.14 3 378792 3795 50222534
Immune thrombocytopenia 18.68 11.14 24 378771 8993 50217336
Neuralgia 18.67 11.14 92 378703 21771 50204558
Blood loss anaemia 18.65 11.14 20 378775 8119 50218210
Respiratory acidosis 18.60 11.14 11 378784 6017 50220312
Hallucinations, mixed 18.56 11.14 4 378791 4099 50222230
Haemolysis 18.53 11.14 11 378784 6005 50220324
Granulocytopenia 18.45 11.14 8 378787 5223 50221106
Hyperuricaemia 18.45 11.14 6 378789 4674 50221655
Blood pressure inadequately controlled 18.38 11.14 5 378790 4375 50221954
Tinnitus 18.37 11.14 129 378666 28003 50198326
Palmoplantar pustulosis 18.36 11.14 19 378776 400 50225929
Antinuclear antibody positive 18.21 11.14 94 378701 6178 50220151
Hypovolaemic shock 18.20 11.14 8 378787 5180 50221149
West Nile viral infection 18.10 11.14 18 378777 361 50225968
Infected seroma 18.07 11.14 10 378785 76 50226253
Middle lobe syndrome 18.03 11.14 8 378787 35 50226294
Cerebral atrophy 17.96 11.14 6 378789 4595 50221734
Hepatic lesion 17.94 11.14 4 378791 4004 50222325
Partial seizures 17.87 11.14 7 378788 4858 50221471
Product residue present 17.84 11.14 3 378792 3669 50222660
Heart rate abnormal 17.84 11.14 4 378791 3988 50222341
Cholangitis 17.82 11.14 6 378789 4573 50221756
Expired product administered 17.80 11.14 9 378786 5373 50220956
Initial insomnia 17.76 11.14 8 378787 5107 50221222
Respiratory syncytial virus infection 17.69 11.14 8 378787 5094 50221235
Gallbladder disorder 17.65 11.14 65 378730 16677 50209652
Atrial septal defect 17.63 11.14 13 378782 6328 50220001
Hyperthermia 17.53 11.14 19 378776 7677 50218652
Duodenal ulcer 17.44 11.14 15 378780 6760 50219569
Incoherent 17.44 11.14 5 378790 4225 50222104
Androgenetic alopecia 17.41 11.14 12 378783 140 50226189
Tenosynovitis stenosans 17.40 11.14 46 378749 2178 50224151
Spinal meningioma benign 17.37 11.14 11 378784 110 50226219
Nystagmus 17.37 11.14 10 378785 5551 50220778
Hypomania 17.36 11.14 6 378789 4499 50221830
Lyme disease 17.32 11.14 50 378745 2493 50223836
Ketoacidosis 17.21 11.14 4 378791 3891 50222438
Larynx irritation 17.13 11.14 11 378784 113 50226216
Micturition urgency 17.12 11.14 22 378773 8242 50218087
Gastroenteritis 17.11 11.14 103 378692 23178 50203151
Symptom masked 17.07 11.14 23 378772 646 50225683
Visual field defect 17.05 11.14 87 378708 5692 50220637
Cryptococcal meningoencephalitis 17.00 11.14 9 378786 62 50226267
Toxic epidermal necrolysis 16.98 11.14 90 378705 20902 50205427
Ocular hyperaemia 16.98 11.14 86 378709 20206 50206123
Antiphospholipid syndrome 16.89 11.14 36 378759 1481 50224848
Therapy change 16.89 11.14 9 378786 5216 50221113
Internal haemorrhage 16.82 11.14 6 378789 4411 50221918
Pleuritic pain 16.80 11.14 94 378701 6372 50219957
Eyelid ptosis 16.80 11.14 13 378782 6174 50220155
Serum ferritin increased 16.76 11.14 9 378786 5193 50221136
Cutaneous lupus erythematosus 16.76 11.14 48 378747 2383 50223946
Neoplasm malignant 16.75 11.14 260 378535 23455 50202874
Peritonitis bacterial 16.65 11.14 7 378788 4654 50221675
Affect lability 16.61 11.14 26 378769 8972 50217357
Cranial nerve injury 16.60 11.14 6 378789 13 50226316
Product preparation error 16.55 11.14 6 378789 4366 50221963
Retinal deposits 16.53 11.14 9 378786 66 50226263
Electrocardiogram ST segment elevation 16.52 11.14 3 378792 3470 50222859
Productive cough 16.51 11.14 286 378509 52408 50173921
Nasal congestion 16.49 11.14 276 378519 50844 50175485
Natural killer-cell leukaemia 16.49 11.14 10 378785 92 50226237
Facial paralysis 16.47 11.14 45 378750 12670 50213659
Injection site haemorrhage 16.46 11.14 93 378702 21253 50205076
Septic shock 16.45 11.14 315 378480 56860 50169469
Brain neoplasm 16.43 11.14 4 378791 3769 50222560
Epigastric discomfort 16.37 11.14 87 378708 5783 50220546
Skin reaction 16.35 11.14 145 378650 11423 50214906
Application site pruritus 16.34 11.14 4 378791 3755 50222574
Wrong product administered 16.23 11.14 10 378785 5350 50220979
Eosinophilia 16.21 11.14 78 378717 18574 50207755
Dermatomyositis 16.21 11.14 44 378751 2117 50224212
Intestinal ischaemia 16.17 11.14 16 378779 6741 50219588
Incorrect dosage administered 16.09 11.14 38 378757 1676 50224653
Apnoea 16.09 11.14 17 378778 6949 50219380
Anaphylactoid reaction 16.08 11.14 3 378792 3403 50222926
Drug screen positive 16.05 11.14 3 378792 3399 50222930
Hypokinesia 16.01 11.14 43 378752 12174 50214155
Nephropathy toxic 15.99 11.14 22 378773 8007 50218322
Autoimmune haemolytic anaemia 15.99 11.14 5 378790 3994 50222335
Fibrin D dimer increased 15.94 11.14 6 378789 4266 50222063
Clostridial infection 15.93 11.14 5 378790 3985 50222344
Weight fluctuation 15.90 11.14 18 378777 7130 50219199
Gingival pain 15.83 11.14 13 378782 5993 50220336
Device failure 15.81 11.14 11 378784 5517 50220812
Hypergammaglobulinaemia 15.70 11.14 18 378777 427 50225902
Viral infection 15.67 11.14 146 378649 29840 50196489
Mycobacterial infection 15.66 11.14 36 378759 1560 50224769
Obsessive-compulsive disorder 15.64 11.14 3 378792 3337 50222992
Gastric ulcer haemorrhage 15.59 11.14 7 378788 4477 50221852
Cytopenia 15.59 11.14 26 378769 8749 50217580
Skin irritation 15.57 11.14 21 378774 7706 50218623
Gonorrhoea 15.55 11.14 10 378785 103 50226226
Atelectasis 15.53 11.14 77 378718 18193 50208136
Anticoagulation drug level increased 15.53 11.14 12 378783 169 50226160
Food allergy 15.51 11.14 23 378772 8114 50218215
Bacterial test positive 15.47 11.14 8 378787 4715 50221614
Atrioventricular block second degree 15.45 11.14 4 378791 3617 50222712
Cerebellar syndrome 15.45 11.14 3 378792 3308 50223021
Anterior chamber cleavage syndrome 15.36 11.14 12 378783 172 50226157
Contraindication to medical treatment 15.34 11.14 21 378774 599 50225730
Blood thyroid stimulating hormone decreased 15.33 11.14 6 378789 4166 50222163
Cerebral ischaemia 15.31 11.14 13 378782 5895 50220434
Left ventricular dysfunction 15.31 11.14 35 378760 10471 50215858
Granulomatous dermatitis 15.31 11.14 10 378785 106 50226223
Rash papular 15.31 11.14 46 378749 12558 50213771
Amylase increased 15.27 11.14 11 378784 5419 50220910
Peripheral coldness 15.19 11.14 34 378761 10249 50216080
Haemolytic anaemia 15.19 11.14 29 378766 9263 50217066
Lung neoplasm malignant 15.12 11.14 62 378733 15422 50210907
Macular degeneration 15.08 11.14 56 378739 14332 50211997
Cardiac failure acute 15.07 11.14 24 378771 8226 50218103
Posterior reversible encephalopathy syndrome 15.06 11.14 59 378736 14869 50211460
Premature delivery 15.06 11.14 255 378540 23408 50202921
Hypoxic-ischaemic encephalopathy 15.01 11.14 5 378790 3837 50222492
Osteopenia 15.00 11.14 194 378601 16824 50209505
Ovarian cyst 14.98 11.14 54 378741 13942 50212387
Exercise tolerance decreased 14.89 11.14 9 378786 4865 50221464
Neck surgery 14.85 11.14 34 378761 1469 50224860
Faeces soft 14.80 11.14 6 378789 4078 50222251
Fracture delayed union 14.79 11.14 44 378751 2232 50224097
Atrioventricular block 14.75 11.14 16 378779 6462 50219867
Adenoiditis 14.73 11.14 7 378788 37 50226292
Depressive symptom 14.72 11.14 3 378792 3197 50223132
Eructation 14.71 11.14 19 378776 7102 50219227
Restless legs syndrome 14.69 11.14 65 378730 15832 50210497
Rib fracture 14.68 11.14 84 378711 19137 50207192
Retinal haemorrhage 14.65 11.14 8 378787 4573 50221756
Extra dose administered 14.65 11.14 10 378785 5066 50221263
Pneumonia fungal 14.63 11.14 7 378788 4313 50222016
Diaphragm muscle weakness 14.55 11.14 6 378789 21 50226308
Insomnia 14.55 11.14 1119 377676 173746 50052583
Coronary artery stenosis 14.44 11.14 7 378788 4282 50222047
Unevaluable event 14.44 11.14 250 378545 45816 50180513
Toxic skin eruption 14.44 11.14 40 378755 11211 50215118
Creatinine urine abnormal 14.43 11.14 7 378788 39 50226290
Placenta accreta 14.42 11.14 12 378783 189 50226140
Pleuropericarditis 14.39 11.14 13 378782 230 50226099
Uterine leiomyoma 14.38 11.14 23 378772 7868 50218461
Abortion incomplete 14.24 11.14 3 378792 3123 50223206
Fluid intake reduced 14.21 11.14 3 378792 3119 50223210
Nocardiosis 14.19 11.14 36 378759 1662 50224667
Pruritus allergic 14.15 11.14 28 378767 1092 50225237
Respiratory rate decreased 14.12 11.14 3 378792 3105 50223224
Humerus fracture 14.07 11.14 22 378773 7596 50218733
Drug tolerance 14.05 11.14 74 378721 4902 50221427
Monocyte count increased 14.05 11.14 80 378715 5459 50220870
Generalised oedema 14.03 11.14 54 378741 13677 50212652
Ocular sarcoidosis 14.01 11.14 7 378788 42 50226287
Venous thrombosis 13.99 11.14 8 378787 4458 50221871
Drooling 13.95 11.14 4 378791 3380 50222949
Exposure to toxic agent 13.88 11.14 5 378790 3653 50222676
Gastric disorder 13.88 11.14 304 378491 29244 50197085
Gangrene 13.87 11.14 9 378786 4683 50221646
Tricuspid valve incompetence 13.85 11.14 49 378746 12721 50213608
Multiple system atrophy 13.77 11.14 12 378783 202 50226127
Congenital osteodystrophy 13.75 11.14 6 378789 25 50226304
Angina unstable 13.74 11.14 18 378777 6688 50219641
Breast pain 13.73 11.14 22 378773 7522 50218807
Neuropsychiatric lupus 13.72 11.14 11 378784 164 50226165
Dermatitis exfoliative 13.71 11.14 11 378784 5131 50221198
Antinuclear antibody negative 13.67 11.14 12 378783 204 50226125
Gastritis erosive 13.67 11.14 11 378784 5123 50221206
Normochromic normocytic anaemia 13.61 11.14 7 378788 4139 50222190
Red blood cell count decreased 13.58 11.14 175 378620 33660 50192669
Vitamin D deficiency 13.57 11.14 42 378753 11360 50214969
Rheumatoid factor 13.52 11.14 8 378787 70 50226259
Gastrointestinal toxicity 13.51 11.14 70 378725 4607 50221722
Monocyte count abnormal 13.50 11.14 11 378784 168 50226161
Intervertebral disc compression 13.49 11.14 25 378770 928 50225401
Blindness 13.44 11.14 75 378720 17194 50209135
Bursitis infective 13.42 11.14 29 378766 1205 50225124
Urticarial vasculitis 13.42 11.14 19 378776 560 50225769
Iodine allergy 13.37 11.14 21 378774 680 50225649
Petit mal epilepsy 13.35 11.14 4 378791 3285 50223044
Urine analysis abnormal 13.33 11.14 8 378787 4342 50221987
Retinogram abnormal 13.29 11.14 10 378785 135 50226194
Gastric ulcer 13.28 11.14 99 378696 21206 50205123
Urosepsis 13.25 11.14 65 378730 15400 50210929
Refusal of treatment by patient 13.24 11.14 11 378784 5042 50221287
Decubitus ulcer 13.22 11.14 32 378763 9386 50216943
Systemic inflammatory response syndrome 13.22 11.14 11 378784 5038 50221291
Spinal cord infection 13.21 11.14 19 378776 568 50225761
Ovarian granulosa cell tumour 13.20 11.14 5 378790 13 50226316
Potentiating drug interaction 13.20 11.14 6 378789 3810 50222519
Oropharyngeal pain 13.19 11.14 463 378332 77338 50148991
Muscle haemorrhage 13.15 11.14 3 378792 2955 50223374
Allergy to vaccine 13.13 11.14 11 378784 175 50226154
Rhinitis allergic 13.10 11.14 21 378774 7179 50219150
Post-traumatic stress disorder 13.07 11.14 8 378787 4295 50222034
Vaginal discharge 13.01 11.14 12 378783 5228 50221101
Non-small cell lung cancer 13.01 11.14 3 378792 2934 50223395
Lupus enteritis 13.01 11.14 7 378788 50 50226279
Catheterisation cardiac 13.00 11.14 7 378788 4033 50222296
Dermatitis bullous 12.98 11.14 21 378774 7152 50219177
Oral lichen planus 12.98 11.14 18 378777 520 50225809
Bipolar disorder 12.98 11.14 19 378776 6738 50219591
Brain natriuretic peptide increased 12.96 11.14 9 378786 4518 50221811
Atrial flutter 12.93 11.14 29 378766 8734 50217595
Foetal movement disorder 12.87 11.14 4 378791 4 50226325
Cerebral haematoma 12.86 11.14 4 378791 3207 50223122
Dry eye 12.86 11.14 323 378472 31772 50194557
Intrauterine infection 12.85 11.14 9 378786 108 50226221
Treatment noncompliance 12.83 11.14 154 378641 29996 50196333
Performance status decreased 12.76 11.14 4 378791 3191 50223138
Affective disorder 12.71 11.14 12 378783 5169 50221160
Erythematotelangiectatic rosacea 12.69 11.14 5 378790 15 50226314
Hyperinsulinaemic hypoglycaemia 12.67 11.14 7 378788 53 50226276
Pneumonia bacterial 12.67 11.14 22 378773 7287 50219042
Urine leukocyte esterase positive 12.66 11.14 3 378792 2880 50223449
Cytomegalovirus viraemia 12.65 11.14 10 378785 4699 50221630
Pre-existing condition improved 12.64 11.14 21 378774 7076 50219253
Coronary artery occlusion 12.63 11.14 23 378772 7480 50218849
Colon cancer 12.63 11.14 29 378766 8662 50217667
Culture urine positive 12.62 11.14 5 378790 3446 50222883
Blood glucose abnormal 12.58 11.14 19 378776 6653 50219676
Haematocrit decreased 12.57 11.14 185 378610 34791 50191538
Heparin-induced thrombocytopenia 12.57 11.14 7 378788 3958 50222371
C-reactive protein decreased 12.56 11.14 22 378773 781 50225548
Stent placement 12.54 11.14 5 378790 3433 50222896
Gastrointestinal infection 12.53 11.14 21 378774 7053 50219276
Eye irritation 12.51 11.14 76 378719 17064 50209265
Facial paresis 12.50 11.14 4 378791 3148 50223181
Mitral valve incompetence 12.47 11.14 78 378717 17393 50208936
Overwork 12.46 11.14 7 378788 55 50226274
Acute vestibular syndrome 12.46 11.14 5 378790 16 50226313
Parosmia 12.46 11.14 9 378786 4427 50221902
Coombs positive haemolytic anaemia 12.45 11.14 14 378781 325 50226004
Hepatitis 12.45 11.14 316 378479 31137 50195192
Root canal infection 12.42 11.14 12 378783 232 50226097
Blood creatine increased 12.36 11.14 11 378784 4876 50221453
Atrioventricular block first degree 12.34 11.14 17 378778 6184 50220145
Metastases to peritoneum 12.34 11.14 3 378792 2830 50223499
Portal hypertension 12.27 11.14 5 378790 3387 50222942
Localised oedema 12.26 11.14 11 378784 4856 50221473
Vitamin D decreased 12.25 11.14 28 378767 8378 50217951
Forced expiratory volume decreased 12.23 11.14 9 378786 4385 50221944
Cataract 12.22 11.14 451 378344 46849 50179480
Paradoxical drug reaction 12.21 11.14 6 378789 3641 50222688
Formication 12.20 11.14 6 378789 3640 50222689
Cardiopulmonary failure 12.15 11.14 5 378790 3368 50222961
Inflammatory marker increased 12.14 11.14 78 378717 5556 50220773
Exposed bone in jaw 12.13 11.14 3 378792 2797 50223532
Infusion site swelling 12.08 11.14 22 378773 7154 50219175
Nerve injury 12.02 11.14 28 378767 8322 50218007
Disease complication 12.01 11.14 3 378792 2779 50223550
DNA antibody 12.01 11.14 6 378789 36 50226293
Areflexia 12.00 11.14 3 378792 2777 50223552
White blood cells urine positive 11.95 11.14 10 378785 4568 50221761
Hepatitis cholestatic 11.95 11.14 17 378778 6100 50220229
Pathogen resistance 11.93 11.14 15 378780 5674 50220655
Anaphylactic shock 11.93 11.14 95 378700 20060 50206269
Autoimmune hepatitis 11.83 11.14 24 378771 7495 50218834
Lip ulceration 11.83 11.14 35 378760 1770 50224559
Blood uric acid increased 11.82 11.14 7 378788 3827 50222502
Multiple-drug resistance 11.80 11.14 5 378790 3309 50223020
Thoracic vertebral fracture 11.79 11.14 8 378787 4065 50222264
Hereditary angioedema 11.78 11.14 14 378781 5428 50220901
Varicose vein 11.72 11.14 9 378786 4291 50222038
Mycobacterium marinum infection 11.71 11.14 11 378784 205 50226124
Central nervous system lupus 11.69 11.14 13 378782 298 50226031
Gastric cancer 11.67 11.14 4 378791 3014 50223315
Eczema 11.67 11.14 111 378684 22591 50203738
Infection reactivation 11.67 11.14 24 378771 963 50225366
Occult blood positive 11.66 11.14 5 378790 3286 50223043
Smear cervix abnormal 11.66 11.14 46 378749 2695 50223634
Catheter site infection 11.64 11.14 9 378786 4277 50222052
Culture tissue specimen positive 11.62 11.14 4 378791 7 50226322
Peripheral ischaemia 11.59 11.14 9 378786 4267 50222062
Anticipatory anxiety 11.55 11.14 13 378782 302 50226027
C-reactive protein 11.55 11.14 22 378773 834 50225495
Urine abnormality 11.54 11.14 18 378777 6220 50220109
Transaminases increased 11.51 11.14 143 378652 27681 50198648
Mood swings 11.51 11.14 71 378724 15883 50210446
Obesity 11.50 11.14 183 378612 16592 50209737
Aortic arteriosclerosis 11.49 11.14 14 378781 5368 50220961
Injection site swelling 11.45 11.14 232 378563 41541 50184788
Blood lactic acid increased 11.43 11.14 15 378780 5570 50220759
Papulopustular rosacea 11.43 11.14 5 378790 21 50226308
Injection site induration 11.42 11.14 29 378766 8368 50217961
Screaming 11.42 11.14 4 378791 2974 50223355
Decreased interest 11.41 11.14 4 378791 2972 50223357
Thyroid disorder 11.38 11.14 145 378650 12532 50213797
Transient hypogammaglobulinaemia of infancy 11.37 11.14 6 378789 41 50226288
Electrocardiogram abnormal 11.36 11.14 25 378770 7580 50218749
Intervertebral disc space narrowing 11.33 11.14 23 378772 914 50225415
Kidney transplant rejection 11.31 11.14 8 378787 3979 50222350
Ganglioneuroma 11.29 11.14 9 378786 133 50226196
Scleritis 11.27 11.14 51 378744 3176 50223153
Blepharospasm 11.24 11.14 4 378791 2944 50223385
Vaginal haematoma 11.23 11.14 9 378786 134 50226195
Tooth loss 11.23 11.14 18 378777 6152 50220177
Bowel movement irregularity 11.21 11.14 8 378787 3960 50222369
Endocarditis 11.21 11.14 13 378782 5094 50221235
Complement factor C3 decreased 11.20 11.14 11 378784 217 50226112
Photopsia 11.20 11.14 8 378787 3958 50222371
Herpes zoster cutaneous disseminated 11.18 11.14 9 378786 135 50226194
Staphylococcal bacteraemia 11.16 11.14 12 378783 4865 50221464

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 3990.46 13.39 3934 58045 296866 29215682
Drug ineffective 2022.59 13.39 3074 58905 360096 29152452
Rheumatoid arthritis 1410.22 13.39 863 61116 31289 29481259
Drug intolerance 1298.66 13.39 957 61022 47422 29465126
Joint swelling 1175.22 13.39 911 61068 48719 29463829
Synovitis 982.26 13.39 472 61507 10418 29502130
Contraindicated product administered 842.94 13.39 507 61472 17759 29494789
Treatment failure 714.47 13.39 603 61376 36336 29476212
Apparent death 485.15 13.39 205 61774 3299 29509249
Therapeutic product effect decreased 438.58 13.39 415 61564 29036 29483512
C-reactive protein abnormal 432.88 13.39 230 61749 6306 29506242
Arthropathy 386.11 13.39 337 61642 21217 29491331
Bone erosion 377.19 13.39 160 61819 2600 29509948
Electrocardiogram QT prolonged 365.91 13.39 414 61565 35723 29476825
Arthralgia 348.38 13.39 847 61132 138770 29373778
Diverticulitis 317.43 13.39 277 61702 17427 29495121
Red blood cell sedimentation rate abnormal 306.40 13.39 131 61848 2172 29510376
Pain 305.01 13.39 918 61061 170514 29342034
Death 296.10 13.39 176 61803 341908 29170640
Red blood cell sedimentation rate increased 270.78 13.39 178 61801 7283 29505265
Loss of personal independence in daily activities 270.35 13.39 299 61680 25141 29487407
Musculoskeletal stiffness 267.42 13.39 360 61619 37098 29475450
Mobility decreased 236.78 13.39 281 61698 25499 29487049
Long QT syndrome 203.80 13.39 98 61881 2160 29510388
Condition aggravated 202.67 13.39 720 61259 145575 29366973
C-reactive protein increased 201.44 13.39 345 61634 43918 29468630
Febrile neutropenia 197.26 13.39 9 61970 112231 29400317
Impaired work ability 191.25 13.39 129 61850 5511 29507037
Sleep disorder due to general medical condition, insomnia type 191.08 13.39 79 61900 1199 29511349
Hand deformity 190.90 13.39 92 61887 2038 29510510
Drug hypersensitivity 180.87 13.39 425 61554 67981 29444567
Rheumatoid factor negative 175.76 13.39 66 61913 764 29511784
Intentional product use issue 172.39 13.39 315 61664 42183 29470365
Peripheral swelling 171.77 13.39 399 61580 63340 29449208
Rheumatoid factor positive 171.57 13.39 61 61918 597 29511951
Therapeutic product effect incomplete 162.80 13.39 294 61685 39011 29473537
Hepatitis 159.42 13.39 207 61772 20576 29491972
Lymphoma 150.95 13.39 141 61838 9687 29502861
Drug effective for unapproved indication 149.31 13.39 69 61910 1386 29511162
Knee arthroplasty 148.81 13.39 112 61867 5697 29506851
Anaemia 141.39 13.39 128 61851 200823 29311725
Pulmonary thrombosis 140.90 13.39 114 61865 6451 29506097
Polyarthritis 135.59 13.39 91 61888 3854 29508694
Product use in unapproved indication 135.33 13.39 445 61534 86430 29426118
Gastrointestinal disorder 132.18 13.39 225 61754 28481 29484067
Onychoclasis 131.24 13.39 67 61912 1686 29510862
Constipation 128.02 13.39 40 61939 114120 29398428
Drug ineffective for unapproved indication 124.01 13.39 151 61828 14063 29498485
Dehydration 122.06 13.39 44 61935 114704 29397844
Herpes zoster 119.61 13.39 221 61758 29831 29482717
Drug tolerance decreased 117.19 13.39 57 61922 1289 29511259
Terminal state 116.27 13.39 79 61900 3415 29509133
Joint stiffness 115.83 13.39 120 61859 9353 29503195
Osteoarthritis 115.62 13.39 165 61814 17938 29494610
Arthritis 112.41 13.39 194 61785 24825 29487723
Malignant neoplasm progression 112.27 13.39 12 61967 73847 29438701
Hypotension 110.02 13.39 148 61831 194206 29318342
Limb discomfort 109.50 13.39 117 61862 9451 29503097
Decreased appetite 108.96 13.39 87 61892 145255 29367293
Toxicity to various agents 104.75 13.39 126 61853 173535 29339013
Acne cystic 103.34 13.39 39 61940 458 29512090
Rheumatoid nodule 103.21 13.39 61 61918 2061 29510487
Drug specific antibody present 102.51 13.39 65 61914 2496 29510052
Joint lock 101.76 13.39 49 61930 1083 29511465
Anti-cyclic citrullinated peptide antibody positive 100.21 13.39 44 61935 780 29511768
Vomiting 98.96 13.39 184 61795 212076 29300472
Overdose 96.84 13.39 24 61955 79795 29432753
Tooth loss 96.69 13.39 72 61907 3602 29508946
Diarrhoea 96.24 13.39 366 61613 332332 29180216
Pyrexia 95.60 13.39 298 61681 287324 29225224
Seizure 95.18 13.39 38 61941 93085 29419463
Acute kidney injury 91.59 13.39 270 61709 264997 29247551
Bone cyst 91.04 13.39 37 61942 536 29512012
Abdominal pain 90.65 13.39 90 61889 135267 29377281
Confusional state 84.51 13.39 86 61893 127791 29384757
Mass 83.22 13.39 88 61891 7023 29505525
Disability 82.95 13.39 71 61908 4345 29508203
Physical disability 82.63 13.39 44 61935 1210 29511338
Photosensitivity reaction 80.17 13.39 98 61881 9160 29503388
X-ray abnormal 79.86 13.39 32 61947 446 29512102
Systemic lupus erythematosus 78.28 13.39 55 61924 2511 29510037
Completed suicide 78.26 13.39 46 61933 90200 29422348
Nodule 77.83 13.39 73 61906 5039 29507509
Psoriatic arthropathy 76.84 13.39 122 61857 14569 29497979
Intestinal polyp 74.64 13.39 37 61942 873 29511675
Drug abuse 73.20 13.39 38 61941 79845 29432703
Syncope 72.67 13.39 40 61939 81331 29431217
Cytology abnormal 71.09 13.39 28 61951 372 29512176
Ill-defined disorder 70.99 13.39 104 61875 11574 29500974
Drug use disorder 70.43 13.39 58 61921 3364 29509184
Hip arthroplasty 69.73 13.39 60 61919 3698 29508850
Joint arthroplasty 69.18 13.39 32 61947 644 29511904
Fall 67.27 13.39 172 61807 177006 29335542
Blood glucose increased 67.27 13.39 20 61959 58964 29453584
Foot deformity 66.30 13.39 60 61919 3955 29508593
Loss of consciousness 63.84 13.39 38 61941 74018 29438530
Pulmonary fibrosis 63.75 13.39 116 61863 15466 29497082
Bladder transitional cell carcinoma 62.03 13.39 47 61932 2414 29510134
Rhabdomyolysis 61.80 13.39 25 61954 60783 29451765
Hypertransaminasaemia 61.74 13.39 55 61924 3551 29508997
Arthritis bacterial 61.46 13.39 60 61919 4353 29508195
Hyperkalaemia 61.17 13.39 26 61953 61366 29451182
Alopecia 60.96 13.39 128 61851 18956 29493592
Neoplasm malignant 60.57 13.39 119 61860 16806 29495742
COVID-19 treatment 59.50 13.39 22 61957 243 29512305
Drug dependence 59.36 13.39 134 61845 20847 29491701
Skin ulcer 58.60 13.39 125 61854 18715 29493833
Pain in extremity 58.48 13.39 414 61565 110019 29402529
Platelet count decreased 57.82 13.39 81 61898 104591 29407957
Musculoskeletal pain 56.87 13.39 161 61818 28792 29483756
Victim of child abuse 56.67 13.39 30 61949 815 29511733
Hospitalisation 55.42 13.39 14 61965 45974 29466574
Dyspnoea 55.21 13.39 430 61549 326302 29186246
Intestinal sepsis 55.04 13.39 24 61955 418 29512130
Thrombocytopenia 54.99 13.39 126 61853 134697 29377851
Urinary tract infection 54.54 13.39 43 61936 72311 29440237
General physical health deterioration 54.45 13.39 82 61897 102775 29409773
Grip strength decreased 53.64 13.39 42 61937 2265 29510283
Inflammation 52.30 13.39 134 61845 22594 29489954
Blood creatinine increased 52.01 13.39 61 61918 85041 29427507
Plasma cell myeloma 51.63 13.39 8 61971 37107 29475441
Coma 51.59 13.39 10 61969 39440 29473108
Hallucination 51.27 13.39 15 61964 44697 29467851
Deep vein thrombosis 51.13 13.39 247 61732 57152 29455396
Premature baby 50.72 13.39 112 61867 17168 29495380
Blood pressure diastolic abnormal 49.93 13.39 42 61937 2509 29510039
Neutropenia 49.07 13.39 129 61850 131582 29380966
No adverse event 48.74 13.39 111 61868 17367 29495181
Gastric disorder 48.05 13.39 83 61896 10621 29501927
Dizziness 47.62 13.39 220 61759 189464 29323084
Soft tissue swelling 47.52 13.39 20 61959 318 29512230
Epistaxis 46.75 13.39 25 61954 51679 29460869
Ascites 46.40 13.39 10 61969 36609 29475939
Gait inability 46.13 13.39 112 61867 18263 29494285
Seronegative arthritis 46.09 13.39 27 61952 897 29511651
Skin laceration 46.07 13.39 83 61896 10979 29501569
Swelling 45.54 13.39 170 61809 35113 29477435
Liver function test increased 45.51 13.39 86 61893 11799 29500749
Renal impairment 44.84 13.39 63 61916 81270 29431278
Prerenal failure 44.74 13.39 34 61945 1754 29510794
Neutrophil count decreased 44.12 13.39 18 61961 43549 29468999
Somnolence 44.06 13.39 81 61898 93874 29418674
Cardiac failure 43.13 13.39 62 61917 79225 29433323
Lupus nephritis 42.88 13.39 17 61962 230 29512318
Gastrointestinal haemorrhage 42.47 13.39 63 61916 79470 29433078
Therapeutic response decreased 42.41 13.39 131 61848 24580 29487968
Blood pressure systolic abnormal 41.11 13.39 35 61944 2126 29510422
Skin mass 40.98 13.39 43 61936 3400 29509148
Oral surgery 40.86 13.39 21 61958 536 29512012
Immobile 39.95 13.39 35 61944 2210 29510338
Cardiac arrest 38.20 13.39 76 61903 85515 29427033
Malaise 37.76 13.39 189 61790 159413 29353135
C-reactive protein decreased 37.72 13.39 29 61950 1522 29511026
Pneumonia aspiration 37.49 13.39 15 61964 36722 29475826
Medical device implantation 37.39 13.39 20 61959 555 29511993
Hepatic function abnormal 36.95 13.39 18 61961 39241 29473307
Blood pressure decreased 36.89 13.39 25 61954 45452 29467096
Limb deformity 36.75 13.39 19 61960 491 29512057
Hyperglycaemia 36.66 13.39 13 61966 34274 29478274
Anxiety 36.23 13.39 78 61901 85287 29427261
Orthostatic hypotension 36.16 13.39 3 61976 22626 29489922
Disorientation 35.53 13.39 9 61970 29506 29483042
Pulmonary embolism 35.40 13.39 278 61701 76256 29436292
Restlessness 35.21 13.39 3 61976 22142 29490406
Disturbance in attention 33.80 13.39 3 61976 21421 29491127
Pancytopenia 33.65 13.39 78 61901 83090 29429458
Unresponsive to stimuli 33.64 13.39 6 61973 25120 29487428
Fine motor skill dysfunction 33.42 13.39 27 61952 1524 29511024
Blood urea increased 33.02 13.39 9 61970 28103 29484445
Infection 32.90 13.39 274 61705 76477 29436071
Blood pressure fluctuation 32.79 13.39 104 61875 19790 29492758
International normalised ratio increased 32.64 13.39 27 61952 44345 29468203
Lymphoedema 32.59 13.39 38 61941 3379 29509169
Heart block congenital 32.32 13.39 9 61970 35 29512513
Low birth weight baby 31.99 13.39 53 61926 6555 29505993
Dysphagia 31.83 13.39 41 61938 54885 29457663
Abdominal discomfort 31.67 13.39 190 61789 47713 29464835
Liver injury 31.47 13.39 77 61902 12613 29499935
Disease progression 31.43 13.39 79 61900 81837 29430711
Lethargy 31.37 13.39 20 61959 37560 29474988
Hypoglycaemia 31.34 13.39 33 61946 48313 29464235
Dactylitis 31.28 13.39 19 61960 675 29511873
Joint range of motion decreased 31.27 13.39 50 61929 6004 29506544
Basal cell carcinoma 31.23 13.39 92 61887 16818 29495730
Dyskinesia 31.13 13.39 3 61976 20058 29492490
Agitation 31.09 13.39 37 61942 51267 29461281
Haematuria 31.08 13.39 28 61951 44111 29468437
Aggression 30.95 13.39 18 61961 35523 29477025
Herpes simplex viraemia 30.93 13.39 10 61969 71 29512477
Fatigue 30.85 13.39 473 61506 316348 29196200
Intentional overdose 30.17 13.39 22 61957 38506 29474042
Bone marrow failure 30.05 13.39 10 61969 27439 29485109
Hepatic enzyme increased 29.76 13.39 145 61834 33654 29478894
Dysarthria 29.35 13.39 14 61965 30897 29481651
Sensitivity to weather change 29.10 13.39 24 61955 1395 29511153
Asthenia 28.91 13.39 300 61679 214950 29297598
Metabolic acidosis 28.85 13.39 22 61957 37640 29474908
Haematemesis 28.71 13.39 8 61971 24618 29487930
Chest pain 28.57 13.39 129 61850 111844 29400704
Medication error 28.54 13.39 5 61974 21206 29491342
Joint ankylosis 28.38 13.39 15 61964 406 29512142
Neoplasm progression 28.32 13.39 3 61976 18609 29493939
Irritability 28.16 13.39 6 61973 22146 29490402
Abdominal distension 27.94 13.39 33 61946 45878 29466670
Hyponatraemia 27.71 13.39 63 61916 67570 29444978
Maculopathy 27.70 13.39 19 61960 834 29511714
Foetal exposure during pregnancy 27.49 13.39 142 61837 33725 29478823
White blood cell count increased 27.38 13.39 23 61956 37493 29475055
Respiratory arrest 27.26 13.39 10 61969 25823 29486725
Muscle spasms 27.17 13.39 60 61919 65022 29447526
Cryopyrin associated periodic syndrome 27.02 13.39 9 61970 71 29512477
Blood bilirubin increased 27.00 13.39 19 61960 33874 29478674
Cognitive disorder 26.72 13.39 8 61971 23491 29489057
Interstitial lung disease 26.32 13.39 209 61770 57509 29455039
Vitamin D deficiency 26.31 13.39 44 61935 5485 29507063
External auditory canal atresia 26.25 13.39 11 61968 173 29512375
Flushing 26.23 13.39 14 61965 28978 29483570
Acute lung injury 26.20 13.39 22 61957 1311 29511237
Epidural lipomatosis 25.88 13.39 17 61962 694 29511854
Cerebral haemorrhage 25.86 13.39 17 61962 31409 29481139
Suicidal ideation 25.68 13.39 21 61958 34695 29477853
Thrombosis 25.49 13.39 166 61813 42879 29469669
Juvenile idiopathic arthritis 25.34 13.39 22 61957 1372 29511176
Pneumonia 25.05 13.39 497 61482 319675 29192873
Microcephaly 25.05 13.39 17 61962 733 29511815
Tuberculosis 25.02 13.39 50 61929 7146 29505402
Product use issue 24.96 13.39 189 61790 51255 29461293
Cerebrovascular accident 24.50 13.39 81 61898 76830 29435718
Cytomegalovirus infection 24.48 13.39 9 61970 23206 29489342
Neck mass 24.19 13.39 22 61957 1459 29511089
Aspartate aminotransferase increased 24.16 13.39 56 61923 59669 29452879
Latent tuberculosis 24.02 13.39 19 61960 1040 29511508
Hypofibrinogenaemia 23.94 13.39 22 61957 1479 29511069
Hypophagia 23.93 13.39 7 61972 20865 29491683
Joint effusion 23.62 13.39 36 61943 4148 29508400
Diffuse idiopathic skeletal hyperostosis 23.56 13.39 7 61972 36 29512512
Wheezing 23.50 13.39 21 61958 33219 29479329
Medium-chain acyl-coenzyme A dehydrogenase deficiency 23.40 13.39 7 61972 37 29512511
Pulmonary toxicity 23.38 13.39 39 61940 4851 29507697
Cardio-respiratory arrest 23.37 13.39 44 61935 50557 29461991
Atrial fibrillation 23.34 13.39 128 61851 105518 29407030
Fragile X syndrome 23.25 13.39 7 61972 38 29512510
Hepatic enzyme abnormal 23.18 13.39 26 61953 2216 29510332
Cutaneous lupus erythematosus 23.13 13.39 16 61963 712 29511836
Incorrect dose administered 23.12 13.39 21 61958 32963 29479585
Product quality issue 23.10 13.39 3 61976 15892 29496656
Ocular toxicity 22.68 13.39 10 61969 179 29512369
Glucose-6-phosphate dehydrogenase deficiency 22.62 13.39 9 61970 123 29512425
Iris coloboma 22.50 13.39 6 61973 19 29512529
Encephalitis Japanese B 22.50 13.39 6 61973 19 29512529
Disease recurrence 22.50 13.39 79 61900 15835 29496713
Hepatic cirrhosis 22.43 13.39 74 61905 14370 29498178
Retinal coloboma 22.26 13.39 6 61973 20 29512528
Vision blurred 22.25 13.39 31 61948 40145 29472403
Depressed level of consciousness 22.00 13.39 27 61952 36915 29475633
Osteonecrosis of jaw 21.98 13.39 4 61975 16506 29496042
Alanine aminotransferase abnormal 21.96 13.39 29 61950 2928 29509620
Oral disorder 21.93 13.39 33 61946 3760 29508788
Arthrodesis 21.84 13.39 13 61966 445 29512103
Infection reactivation 21.49 13.39 18 61961 1069 29511479
Septic shock 21.25 13.39 64 61915 62496 29450052
Hypokalaemia 21.18 13.39 46 61933 50157 29462391
Abnormal behaviour 21.17 13.39 11 61968 23116 29489432
Intestinal obstruction 21.14 13.39 7 61972 19270 29493278
Subdural haematoma 21.04 13.39 6 61973 18187 29494361
Coronavirus infection 21.03 13.39 30 61949 3258 29509290
Full blood count decreased 21.02 13.39 4 61975 15988 29496560
Palmar-plantar erythrodysaesthesia syndrome 20.94 13.39 3 61976 14756 29497792
External ear disorder 20.85 13.39 6 61973 27 29512521
Coronary artery disease 20.78 13.39 38 61941 44152 29468396
Acute myocardial infarction 20.76 13.39 44 61935 48394 29464154
Blood potassium increased 20.73 13.39 3 61976 14648 29497900
Drug withdrawal syndrome 20.67 13.39 6 61973 17978 29494570
Trisomy 8 20.61 13.39 7 61972 59 29512489
Meningitis noninfective 20.38 13.39 5 61974 10 29512538
Therapy partial responder 20.37 13.39 38 61941 5161 29507387
Suicide attempt 20.24 13.39 25 61954 34085 29478463
PaO2/FiO2 ratio decreased 20.17 13.39 6 61973 31 29512517
Ossicle disorder 20.01 13.39 6 61973 32 29512516
Anaphylactic reaction 20.00 13.39 17 61962 27556 29484992
Stevens-Johnson syndrome 19.91 13.39 5 61974 16492 29496056
Mycobacterium fortuitum infection 19.88 13.39 9 61970 172 29512376
Panniculitis 19.68 13.39 18 61961 1203 29511345
Red blood cell sedimentation rate 19.57 13.39 13 61966 541 29512007
Cellulitis 19.34 13.39 42 61937 45798 29466750
Mental status changes 19.29 13.39 27 61952 34900 29477648
Haemorrhage 19.26 13.39 41 61938 45031 29467517
Urticaria 19.24 13.39 187 61792 54473 29458075
Blood pressure systolic increased 19.15 13.39 78 61901 16767 29495781
Squamous cell carcinoma 19.15 13.39 56 61923 10195 29502353
Myalgia 19.03 13.39 85 61894 73934 29438614
Jaundice 18.98 13.39 20 61959 29276 29483272
Erectile dysfunction 18.96 13.39 7 61972 18002 29494546
Pneumatosis intestinalis 18.93 13.39 28 61951 3141 29509407
Acute cutaneous lupus erythematosus 18.80 13.39 7 61972 79 29512469
Liver function test 18.63 13.39 6 61973 42 29512506
Maternal exposure during pregnancy 18.54 13.39 32 61947 4091 29508457
Antinuclear antibody positive 18.37 13.39 18 61961 1312 29511236
Urinary retention 18.28 13.39 24 61955 31874 29480674
Methaemoglobinaemia 18.01 13.39 25 61954 2646 29509902
Andersen-Tawil syndrome 17.92 13.39 4 61975 4 29512544
Neonatal lupus erythematosus 17.92 13.39 4 61975 4 29512544
Therapeutic response unexpected 17.90 13.39 49 61930 8589 29503959
Cardiogenic shock 17.75 13.39 9 61970 19181 29493367
Granuloma skin 17.73 13.39 13 61966 635 29511913
Blood creatine phosphokinase increased 17.35 13.39 37 61942 40607 29471941
Hypocalcaemia 17.24 13.39 11 61968 20654 29491894
Neutrophil Pelger-Huet anomaly present 17.19 13.39 9 61970 239 29512309
Scleroderma renal crisis 17.12 13.39 7 61972 103 29512445
Oral pustule 17.08 13.39 9 61970 242 29512306
Viral load abnormal 16.94 13.39 6 61973 58 29512490
Peritonitis 16.94 13.39 5 61974 14819 29497729
Lupus pneumonitis 16.85 13.39 6 61973 59 29512489
Device related infection 16.59 13.39 6 61973 15630 29496918
Unevaluable event 16.56 13.39 23 61956 29828 29482720
Gamma-glutamyltransferase increased 16.50 13.39 19 61960 26718 29485830
Lymphocyte count decreased 16.43 13.39 10 61969 19261 29493287
Bronchopulmonary aspergillosis 16.36 13.39 60 61919 12284 29500264
Melaena 16.33 13.39 25 61954 31151 29481397
Angioedema 16.33 13.39 26 61953 31889 29480659
Stent placement 16.29 13.39 31 61948 4275 29508273
Maternal exposure before pregnancy 16.24 13.39 11 61968 473 29512075
Joint warmth 16.19 13.39 9 61970 270 29512278
Abscess 16.05 13.39 51 61928 9711 29502837
Cytokine storm 16.03 13.39 12 61967 605 29511943
Red blood cell count decreased 16.01 13.39 18 61961 25584 29486964
Ataxia 15.96 13.39 3 61976 12100 29500448
Pancreatitis 15.94 13.39 30 61949 34484 29478064
Angina pectoris 15.91 13.39 21 61958 27829 29484719
Bradycardia 15.90 13.39 77 61902 65552 29446996
Stress ulcer 15.86 13.39 6 61973 71 29512477
Blood pressure diastolic increased 15.79 13.39 28 61951 3658 29508890
Viral vasculitis 15.78 13.39 6 61973 72 29512476
Q fever 15.74 13.39 7 61972 128 29512420
Tuberculin test positive 15.72 13.39 15 61964 1058 29511490
Bursa removal 15.64 13.39 7 61972 130 29512418
Anomalous pulmonary venous connection 15.56 13.39 6 61973 75 29512473
Oedema 15.55 13.39 39 61940 40444 29472104
Gout 15.54 13.39 8 61971 16903 29495645
Metastases to liver 15.51 13.39 3 61976 11853 29500695
Wrist surgery 15.50 13.39 7 61972 133 29512415
Haematocrit decreased 15.47 13.39 23 61956 28999 29483549
Visual acuity reduced 15.29 13.39 6 61973 14870 29497678
Colitis ulcerative 15.16 13.39 4 61975 12765 29499783
Ankle deformity 15.09 13.39 8 61971 218 29512330
Pulmonary oedema 15.03 13.39 43 61936 42692 29469856
Blood parathyroid hormone decreased 14.97 13.39 13 61966 811 29511737
Raoultella ornithinolytica infection 14.92 13.39 4 61975 13 29512535
Hepatic failure 14.90 13.39 27 61952 31485 29481063
Dysuria 14.90 13.39 15 61964 22425 29490123
Disseminated intravascular coagulation 14.88 13.39 12 61967 19968 29492580
Shoulder operation 14.85 13.39 13 61966 820 29511728
Chronic kidney disease 14.84 13.39 34 61945 36382 29476166
Synovial cyst 14.70 13.39 19 61960 1878 29510670
Speech sound disorder 14.56 13.39 7 61972 154 29512394
Acute respiratory distress syndrome 14.53 13.39 90 61889 22845 29489703
Vasculitis 14.51 13.39 43 61936 7885 29504663
Nervousness 14.50 13.39 3 61976 11303 29501245
Retro-orbital neoplasm 14.48 13.39 4 61975 15 29512533
Electrolyte imbalance 14.44 13.39 3 61976 11271 29501277
Cyanosis 14.43 13.39 3 61976 11264 29501284
Faeces discoloured 14.37 13.39 5 61974 13346 29499202
Tender joint count increased 14.34 13.39 5 61974 46 29512502
Encephalopathy 14.32 13.39 27 61952 31016 29481532
Aortoenteric fistula 14.22 13.39 6 61973 96 29512452
Localised infection 14.17 13.39 62 61917 13754 29498794
Disseminated strongyloidiasis 14.11 13.39 6 61973 98 29512450
Oedema peripheral 14.00 13.39 144 61835 103413 29409135
Hallucination, visual 13.95 13.39 7 61972 15008 29497540
Full blood count abnormal 13.95 13.39 7 61972 15006 29497542
Tubulointerstitial nephritis 13.90 13.39 10 61969 17633 29494915
Malnutrition 13.83 13.39 3 61976 10938 29501610
Ventricular fibrillation 13.81 13.39 8 61971 15825 29496723
Neurological examination abnormal 13.79 13.39 8 61971 261 29512287
Aortic bruit 13.68 13.39 7 61972 177 29512371
Therapeutic product effect delayed 13.56 13.39 14 61965 1086 29511462
Herpes dermatitis 13.46 13.39 5 61974 56 29512492
Product dose omission issue 13.45 13.39 133 61846 96250 29416298
Urinary incontinence 13.44 13.39 9 61970 16472 29496076
Olfactory nerve disorder 13.39 13.39 4 61975 21 29512527

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 6525.90 11.13 13554 313546 826693 63344939
Drug intolerance 5127.42 11.13 5502 321598 182490 63989142
Joint swelling 3677.23 11.13 4971 322129 210411 63961221
Synovitis 3512.53 11.13 3346 323754 95744 64075888
Rheumatoid arthritis 3371.38 11.13 4155 322945 160139 64011493
Off label use 3198.07 11.13 8666 318434 624140 63547492
Contraindicated product administered 3127.25 11.13 3265 323835 104564 64067068
Treatment failure 2842.72 11.13 3225 323875 113591 64058041
Therapeutic product effect decreased 2079.89 11.13 2738 324362 112613 64059019
Arthropathy 2035.38 11.13 2776 324324 118191 64053441
Arthralgia 1446.08 11.13 5220 321880 437040 63734592
Systemic lupus erythematosus 1395.97 11.13 1841 325259 75771 64095861
Pain 1289.42 11.13 5880 321220 547631 63624001
C-reactive protein abnormal 1270.36 11.13 1105 325995 27942 64143690
Death 1213.35 11.13 467 326633 482238 63689394
Hand deformity 1211.48 11.13 1542 325558 61229 64110403
Rheumatoid factor positive 1075.99 11.13 1094 326006 33844 64137788
Red blood cell sedimentation rate abnormal 1071.88 11.13 788 326312 15518 64156114
Musculoskeletal stiffness 1055.62 11.13 2085 325015 121121 64050511
Swelling 1021.21 11.13 2405 324695 157813 64013819
Abdominal discomfort 999.40 11.13 2583 324517 179739 63991893
Pemphigus 990.95 11.13 1374 325726 59327 64112305
Peripheral swelling 968.68 11.13 2785 324315 206368 63965264
Anti-cyclic citrullinated peptide antibody positive 949.04 11.13 1213 325887 48349 64123283
Acute kidney injury 905.08 11.13 583 326517 448657 63722975
Alopecia 829.34 11.13 2270 324830 163420 64008212
Drug hypersensitivity 826.73 11.13 2868 324232 234947 63936685
Glossodynia 820.77 11.13 1301 325799 63395 64108237
Therapeutic product effect incomplete 791.10 11.13 1671 325429 101811 64069821
Hepatic enzyme increased 763.71 11.13 1891 325209 128052 64043580
Condition aggravated 754.45 11.13 3805 323295 368621 63803011
Red blood cell sedimentation rate increased 733.84 11.13 848 326252 30387 64141245
Completed suicide 718.98 11.13 134 326966 224280 63947352
Loss of personal independence in daily activities 679.97 11.13 1275 325825 71179 64100453
Febrile neutropenia 648.21 11.13 91 327009 187566 63984066
Pericarditis 640.84 11.13 1143 325957 61373 64110259
Anaemia 638.04 11.13 589 326511 378091 63793541
C-reactive protein increased 561.40 11.13 1385 325715 93524 64078108
Gastrointestinal disorder 560.42 11.13 1337 325763 88372 64083260
Hypersensitivity 527.83 11.13 2183 324917 194269 63977363
Hypotension 527.81 11.13 696 326404 380278 63791354
Wound 511.75 11.13 1171 325929 75306 64096326
Dehydration 504.42 11.13 234 326866 216529 63955103
Bone erosion 492.52 11.13 434 326666 11161 64160471
Malignant neoplasm progression 469.60 11.13 25 327075 112846 64058786
Constipation 464.53 11.13 295 326805 229042 63942590
Arthritis 462.08 11.13 1191 325909 82623 64089009
Infusion related reaction 447.46 11.13 1835 325265 162632 64009000
Rash 445.27 11.13 3899 323201 454650 63716982
Helicobacter infection 440.95 11.13 738 326362 37624 64134008
Infection 440.12 11.13 1981 325119 182899 63988733
Toxicity to various agents 435.46 11.13 734 326366 362779 63808853
Discomfort 434.27 11.13 1138 325962 79740 64091892
Drug abuse 432.49 11.13 75 327025 132299 64039333
Retinal toxicity 431.12 11.13 184 326916 1146 64170486
Maternal exposure during pregnancy 419.23 11.13 1252 325848 94632 64077000
Sleep disorder due to general medical condition, insomnia type 415.57 11.13 586 326514 25684 64145948
Duodenal ulcer perforation 397.81 11.13 666 326434 33959 64137673
Seizure 389.97 11.13 179 326921 166713 64004919
Hyponatraemia 379.14 11.13 139 326961 148200 64023432
Osteoarthritis 375.15 11.13 925 326175 62411 64109221
Psoriatic arthropathy 365.94 11.13 729 326371 42552 64129080
Neutropenia 362.93 11.13 408 326692 239216 63932416
Muscle injury 362.10 11.13 551 326549 25886 64145746
Irritable bowel syndrome 352.14 11.13 659 326441 36710 64134922
Rheumatoid nodule 351.40 11.13 375 326725 12276 64159356
Sinusitis 345.89 11.13 1562 325538 144366 64027266
Product use issue 341.88 11.13 1600 325500 150115 64021517
Mobility decreased 338.18 11.13 1081 326019 84759 64086873
Ill-defined disorder 335.88 11.13 711 326389 43341 64128291
Lower respiratory tract infection 333.97 11.13 1148 325952 93466 64078166
Thrombocytopenia 331.38 11.13 388 326712 223413 63948219
Folliculitis 330.25 11.13 567 326533 29510 64142122
Inflammation 322.50 11.13 891 326209 64409 64107223
Hyperkalaemia 322.30 11.13 61 327039 101068 64070564
Impaired work ability 320.75 11.13 391 326709 14828 64156804
Overdose 309.80 11.13 215 326885 159351 64012281
Gastrointestinal haemorrhage 307.37 11.13 143 326957 132169 64039463
Somnolence 306.93 11.13 348 326752 203297 63968335
Tremor 303.67 11.13 188 326912 148042 64023590
Knee arthroplasty 303.06 11.13 514 326586 26485 64145147
Impaired healing 302.46 11.13 829 326271 59644 64111988
Rhabdomyolysis 293.01 11.13 55 327045 91671 64079961
Fibromyalgia 292.69 11.13 594 326506 35137 64136495
Dyspnoea 290.51 11.13 2296 324804 716378 63455254
Atrial fibrillation 285.36 11.13 268 326832 170821 64000811
Platelet count decreased 280.55 11.13 262 326838 167449 64004183
Bradycardia 275.78 11.13 127 326973 118092 64053540
Musculoskeletal disorder 273.71 11.13 393 326707 17513 64154119
Disability 271.71 11.13 322 326778 11850 64159782
Cardio-respiratory arrest 258.55 11.13 88 327012 98305 64073327
Coma 252.70 11.13 66 327034 87549 64084083
Decreased appetite 245.06 11.13 678 326422 280611 63891021
Cardiac arrest 244.60 11.13 252 326848 153812 64017820
Intentional product use issue 239.62 11.13 1039 326061 94325 64077307
Depressed level of consciousness 239.38 11.13 59 327041 81377 64090255
Lactic acidosis 236.66 11.13 20 327080 61390 64110242
Nasopharyngitis 234.46 11.13 1750 325350 194323 63977309
Drug tolerance decreased 233.51 11.13 229 326871 6769 64164863
Neutrophil count decreased 232.69 11.13 53 327047 77143 64094489
Hip arthroplasty 232.42 11.13 401 326699 20950 64150682
Renal failure 231.19 11.13 352 326748 181336 63990296
Sepsis 230.38 11.13 517 326583 229824 63941808
Joint range of motion decreased 230.12 11.13 378 326722 18965 64152667
Syncope 225.05 11.13 281 326819 157354 64014278
Musculoskeletal pain 223.15 11.13 910 326190 80384 64091248
Blood parathyroid hormone decreased 221.83 11.13 228 326872 7138 64164494
Panniculitis 220.21 11.13 248 326852 8631 64163001
Grip strength decreased 216.51 11.13 282 326818 11442 64160190
Granuloma skin 216.30 11.13 206 326894 5868 64165764
Anxiety 214.14 11.13 441 326659 202208 63969424
Agitation 213.86 11.13 90 327010 88277 64083355
Retinopathy 208.51 11.13 157 326943 3208 64168424
Tachycardia 207.97 11.13 272 326828 149307 64022325
White blood cell count decreased 206.42 11.13 300 326800 157537 64014095
Dizziness 206.14 11.13 1307 325793 428856 63742776
Pneumonia 204.33 11.13 1835 325265 557741 63613891
Hallucination 203.94 11.13 58 327042 72730 64098902
Joint stiffness 203.73 11.13 466 326634 29938 64141694
Metabolic acidosis 203.58 11.13 54 327046 70904 64100728
Cardiac failure 200.67 11.13 225 326875 132148 64039484
Herpes zoster 198.33 11.13 862 326238 78325 64093307
Pulmonary fibrosis 198.06 11.13 456 326644 29422 64142210
Epistaxis 196.06 11.13 128 326972 98003 64073629
International normalised ratio increased 195.85 11.13 78 327022 79089 64092543
Abdominal pain 193.55 11.13 870 326230 311505 63860127
Blister 191.91 11.13 867 326233 80100 64091532
Cerebrovascular accident 189.40 11.13 252 326848 137331 64034301
Fall 186.83 11.13 1292 325808 415534 63756098
Disease progression 186.53 11.13 268 326832 141412 64030220
Polyarthritis 186.17 11.13 238 326862 9477 64162155
Cardiac failure congestive 184.04 11.13 235 326865 130345 64041287
Therapeutic response decreased 182.98 11.13 632 326468 51556 64120076
Nodule 179.76 11.13 325 326775 17622 64154010
Maculopathy 178.53 11.13 127 326973 2369 64169263
Respiratory arrest 177.48 11.13 28 327072 52957 64118675
Lupus nephritis 177.22 11.13 125 326975 2299 64169333
Drug interaction 173.44 11.13 1100 326000 360983 63810649
Joint effusion 170.78 11.13 271 326829 13202 64158430
Blood glucose increased 168.95 11.13 149 326951 97924 64073708
Oedema peripheral 167.79 11.13 528 326572 209789 63961843
Pyrexia 165.08 11.13 1926 325174 556718 63614914
Fine motor skill dysfunction 164.74 11.13 158 326942 4541 64167091
Neoplasm progression 164.48 11.13 11 327089 40953 64130679
Hepatic function abnormal 163.00 11.13 61 327039 64252 64107380
Hypoglycaemia 162.93 11.13 130 326970 89762 64081870
Pneumonia aspiration 162.80 11.13 49 327051 59222 64112410
Vomiting 162.08 11.13 1902 325198 549215 63622417
Cognitive disorder 159.78 11.13 41 327059 55046 64116586
Intentional overdose 158.16 11.13 134 326966 89810 64081822
Multiple sclerosis relapse 156.85 11.13 14 327086 41121 64130511
Foot deformity 154.14 11.13 290 326810 16214 64155418
Osteoporosis 154.01 11.13 517 326583 41563 64130069
Balance disorder 153.84 11.13 120 326980 83806 64087826
Long QT syndrome 152.82 11.13 158 326942 4981 64166651
Pancytopenia 152.06 11.13 311 326789 142998 64028634
Disorientation 151.81 11.13 47 327053 55781 64115851
Tenosynovitis 151.35 11.13 239 326861 11594 64160038
Renal impairment 148.41 11.13 287 326813 134730 64036902
Rheumatoid factor negative 147.18 11.13 83 327017 1010 64170622
Pulmonary embolism 146.63 11.13 328 326772 146028 64025604
Electrocardiogram QT prolonged 146.41 11.13 792 326308 78656 64092976
Deformity 144.55 11.13 169 326931 6128 64165504
Plasma cell myeloma 144.22 11.13 29 327071 46046 64125586
Suicide attempt 144.04 11.13 91 327009 70916 64100716
Melaena 143.97 11.13 46 327054 53502 64118130
Disturbance in attention 143.86 11.13 19 327081 41055 64130577
Cerebral haemorrhage 142.58 11.13 41 327059 51049 64120583
Acute myocardial infarction 141.91 11.13 89 327011 69629 64102003
Dysphagia 141.60 11.13 201 326899 106611 64065021
Hyperglycaemia 141.36 11.13 66 327034 60902 64110730
Blood bilirubin increased 140.24 11.13 58 327042 57495 64114137
Multiple organ dysfunction syndrome 139.30 11.13 186 326914 101227 64070405
Adverse event 139.10 11.13 479 326621 39010 64132622
Asthenia 138.92 11.13 1444 325656 426600 63745032
X-ray abnormal 137.79 11.13 89 327011 1406 64170226
Finger deformity 137.48 11.13 150 326950 5036 64166596
Hyperhidrosis 136.03 11.13 267 326833 124653 64046979
Unresponsive to stimuli 136.00 11.13 43 327057 50350 64121282
Haemoglobin decreased 133.88 11.13 522 326578 194541 63977091
Blood creatinine increased 133.83 11.13 307 326793 135475 64036157
Apparent death 133.76 11.13 110 326990 2566 64169066
Ascites 133.47 11.13 74 327026 61927 64109705
Blood pressure decreased 132.27 11.13 145 326955 86054 64085578
Loss of consciousness 131.00 11.13 355 326745 148010 64023622
Respiratory failure 130.39 11.13 402 326698 160781 64010851
Confusional state 130.31 11.13 783 326317 260361 63911271
Encephalopathy 129.83 11.13 68 327032 58751 64112881
Diverticulitis 129.60 11.13 461 326639 38157 64133475
Physical disability 129.28 11.13 101 326999 2184 64169448
Sedation 127.90 11.13 27 327073 41435 64130197
Muscle spasms 127.87 11.13 333 326767 140690 64030942
Dysarthria 127.74 11.13 71 327029 59335 64112297
Hypoxia 126.93 11.13 156 326944 87993 64083639
Restlessness 126.72 11.13 24 327076 39761 64131871
Aggression 125.57 11.13 39 327061 46193 64125439
Sopor 125.13 11.13 6 327094 29655 64141977
Drug effective for unapproved indication 124.95 11.13 122 326978 3586 64168046
Glaucoma 124.73 11.13 264 326836 16084 64155548
Blood urea increased 124.02 11.13 35 327065 44118 64127514
Hepatic failure 123.82 11.13 63 327037 55331 64116301
Pleural effusion 123.23 11.13 288 326812 126271 64045361
Jaundice 122.95 11.13 46 327054 48466 64123166
Dyskinesia 122.85 11.13 25 327075 39363 64132269
Pulmonary oedema 121.09 11.13 132 326968 78542 64093090
Ulcer 120.75 11.13 321 326779 22669 64148963
Tuberculin test positive 120.71 11.13 110 326990 2958 64168674
Myocardial infarction 120.12 11.13 434 326666 165387 64006245
Elbow deformity 120.11 11.13 77 327023 1200 64170432
Product dose omission issue 119.52 11.13 544 326556 194203 63977429
Joint destruction 119.48 11.13 118 326982 3518 64168114
Spinal stenosis 119.33 11.13 236 326864 13695 64157937
Joint injury 118.10 11.13 318 326782 22629 64149003
Palmar-plantar erythrodysaesthesia syndrome 117.91 11.13 7 327093 28812 64142820
Mental status changes 116.53 11.13 84 327016 61078 64110554
Coronary artery disease 116.45 11.13 82 327018 60351 64111281
Breast cancer stage III 115.96 11.13 105 326995 2800 64168832
Adverse drug reaction 115.40 11.13 497 326603 44967 64126665
Chest pain 114.86 11.13 713 326387 235267 63936365
Stomatitis 114.72 11.13 949 326151 108656 64062976
Accidental overdose 114.06 11.13 17 327083 33540 64138092
Haematuria 113.97 11.13 84 327016 60387 64111245
Oral mucosal exfoliation 113.90 11.13 77 327023 1318 64170314
Joint laxity 113.33 11.13 94 327006 2220 64169412
Urinary retention 111.41 11.13 55 327045 49146 64122486
Shoulder arthroplasty 110.27 11.13 99 327001 2610 64169022
Abnormal behaviour 109.85 11.13 19 327081 33603 64138029
Bone density decreased 109.73 11.13 188 326912 9764 64161868
Diarrhoea 109.70 11.13 2810 324290 719894 63451738
Rheumatic fever 109.70 11.13 181 326919 9113 64162519
SLE arthritis 109.56 11.13 54 327046 488 64171144
Renal phospholipidosis 109.20 11.13 35 327065 79 64171553
Haemorrhage 108.49 11.13 146 326954 79205 64092427
Urinary tract infection 107.98 11.13 709 326391 230887 63940745
Bone marrow failure 106.48 11.13 55 327045 47897 64123735
Blood cholesterol increased 105.35 11.13 518 326582 49548 64122084
Swollen joint count increased 104.90 11.13 160 326940 7529 64164103
Myalgia 104.06 11.13 432 326668 158185 64013447
Pain in extremity 103.83 11.13 2134 324966 300951 63870681
Human antichimeric antibody positive 103.48 11.13 73 327027 1343 64170289
Irritability 103.44 11.13 29 327071 36717 64134915
Seronegative arthritis 103.36 11.13 96 327004 2647 64168985
Musculoskeletal deformity 102.78 11.13 55 327045 599 64171033
Neuroleptic malignant syndrome 102.48 11.13 6 327094 24990 64146642
Diabetic ketoacidosis 101.71 11.13 15 327085 29830 64141802
Drug withdrawal syndrome 101.54 11.13 18 327082 31273 64140359
Epilepsy 101.07 11.13 23 327077 33508 64138124
Liver function test increased 100.76 11.13 366 326734 30604 64141028
Rectal haemorrhage 100.46 11.13 99 327001 61718 64109914
Skin necrosis 99.75 11.13 223 326877 14106 64157526
Serotonin syndrome 98.30 11.13 38 327062 39244 64132388
Lethargy 96.80 11.13 136 326964 72458 64099174
Body height below normal 95.66 11.13 77 327023 1741 64169891
Tubulointerstitial nephritis 93.57 11.13 21 327079 30888 64140744
Respiratory distress 93.17 11.13 77 327023 52254 64119378
Arthrodesis 93.08 11.13 80 327020 1987 64169645
Bone cyst 92.82 11.13 82 327018 2115 64169517
Surgical failure 92.50 11.13 55 327045 744 64170888
Rheumatoid lung 91.95 11.13 86 327014 2393 64169239
Upper gastrointestinal haemorrhage 91.62 11.13 32 327068 35188 64136444
Wrong technique in product usage process 91.43 11.13 117 326983 64857 64106775
Circulatory collapse 90.63 11.13 29 327071 33703 64137929
Hypomagnesaemia 90.52 11.13 38 327062 37338 64134294
Blood alkaline phosphatase increased 90.45 11.13 91 327009 56188 64115444
Blood creatine phosphokinase increased 90.38 11.13 98 327002 58460 64113172
Haematemesis 90.25 11.13 64 327036 46935 64124697
Generalised tonic-clonic seizure 89.57 11.13 45 327055 39812 64131820
Contusion 89.10 11.13 927 326173 113038 64058594
Neurotoxicity 88.41 11.13 16 327084 27388 64144244
Orthostatic hypotension 87.98 11.13 65 327035 46673 64124959
Osteonecrosis of jaw 87.95 11.13 46 327054 39779 64131853
Altered state of consciousness 87.91 11.13 41 327059 37861 64133771
Neuropathy peripheral 86.81 11.13 305 326795 117220 64054412
Fluid retention 86.32 11.13 105 326995 59501 64112131
Eye disorder 85.81 11.13 250 326850 18619 64153013
Gamma-glutamyltransferase increased 85.59 11.13 72 327028 48438 64123194
Blood calcium decreased 84.46 11.13 14 327086 25540 64146092
Lymphocyte count decreased 84.14 11.13 51 327049 40648 64130984
Colitis microscopic 84.06 11.13 142 326958 7290 64164342
Fatigue 83.60 11.13 4616 322484 744114 63427518
Metastases to bone 83.49 11.13 5 327095 20430 64151202
Loose body in joint 82.59 11.13 60 327040 1158 64170474
Sciatica 82.29 11.13 258 326842 20006 64151626
Skin ulcer 82.09 11.13 440 326660 43534 64128098
Tumour lysis syndrome 81.78 11.13 4 327096 19436 64152196
Sleep disorder 80.55 11.13 549 326551 59160 64112472
Vision blurred 80.52 11.13 215 326885 90101 64081531
Emotional distress 80.52 11.13 41 327059 35997 64135635
Acute myeloid leukaemia 80.48 11.13 20 327080 27443 64144189
Epicondylitis 80.03 11.13 70 327030 1781 64169851
Disseminated intravascular coagulation 79.78 11.13 32 327068 32316 64139316
Suicidal ideation 79.76 11.13 134 326966 66408 64105224
Investigation abnormal 79.51 11.13 61 327039 1283 64170349
Exposure during pregnancy 79.36 11.13 669 326431 77006 64094626
Neutropenic sepsis 78.61 11.13 12 327088 23260 64148372
Joint arthroplasty 78.04 11.13 72 327028 1968 64169664
Wrist deformity 77.69 11.13 68 327032 1732 64169900
Red blood cell sedimentation rate 77.57 11.13 95 327005 3619 64168013
Haematoma 76.39 11.13 73 327027 46177 64125455
Mucosal inflammation 75.97 11.13 125 326975 62459 64109173
Status epilepticus 75.91 11.13 10 327090 21653 64149979
Dislocation of vertebra 75.33 11.13 86 327014 3038 64168594
Cholelithiasis 74.95 11.13 72 327028 45434 64126198
Cerebral infarction 74.80 11.13 59 327041 40985 64130647
Chronic kidney disease 74.76 11.13 111 326989 57808 64113824
Acute respiratory failure 73.33 11.13 87 327013 49847 64121785
Hypokalaemia 73.27 11.13 343 326757 121560 64050072
Sensitivity to weather change 72.93 11.13 126 326974 6588 64165044
Cytomegalovirus infection 72.29 11.13 50 327050 37149 64134483
Subdural haematoma 72.10 11.13 26 327074 28028 64143604
Deep vein thrombosis 71.77 11.13 282 326818 104900 64066732
Adverse reaction 71.69 11.13 135 326965 7552 64164080
Intentional self-injury 71.19 11.13 29 327071 29015 64142617
Device expulsion 71.16 11.13 11 327089 21125 64150507
Dysuria 71.09 11.13 65 327035 41992 64129640
Metastases to liver 71.01 11.13 17 327083 23924 64147708
Gastric disorder 70.90 11.13 315 326785 28882 64142750
Small intestinal obstruction 69.41 11.13 17 327083 23556 64148076
Aphasia 69.40 11.13 63 327037 40843 64130789
Dysgeusia 69.05 11.13 82 327018 46965 64124667
Bone pain 68.67 11.13 84 327016 47488 64124144
COVID-19 treatment 68.59 11.13 37 327063 410 64171222
Femur fracture 68.15 11.13 348 326752 33787 64137845
Hospitalisation 67.82 11.13 178 326922 75029 64096603
Mouth ulceration 67.77 11.13 335 326765 32109 64139523
Viral upper respiratory tract infection 67.76 11.13 137 326963 8078 64163554
Synovial cyst 67.75 11.13 132 326968 7575 64164057
Blood lactate dehydrogenase increased 67.61 11.13 42 327058 33036 64138596
Intentional product misuse 67.59 11.13 168 326932 72127 64099505
Drug eruption 67.06 11.13 361 326739 35775 64135857
Ear pain 67.05 11.13 279 326821 24857 64146775
Blood iron abnormal 67.01 11.13 52 327048 1113 64170519
Bone density abnormal 66.92 11.13 76 327024 2669 64168963
Device related infection 66.71 11.13 36 327064 30590 64141042
Product quality issue 66.43 11.13 34 327066 29765 64141867
Hallucination, visual 66.28 11.13 29 327071 27805 64143827
Arrhythmia 65.90 11.13 104 326996 52840 64118792
Basal cell carcinoma 65.54 11.13 320 326780 30518 64141114
Therapy non-responder 64.91 11.13 563 326537 65336 64106296
Hepatitis 64.42 11.13 424 326676 45158 64126474
Pancreatitis 64.34 11.13 128 326972 59479 64112153
Pallor 64.29 11.13 61 327039 38720 64132912
Colitis 64.19 11.13 125 326975 58549 64113083
Premature delivery 64.16 11.13 224 326876 18365 64153267
Drug ineffective for unapproved indication 63.99 11.13 320 326780 30813 64140819
Transient ischaemic attack 63.79 11.13 78 327022 44104 64127528
Enthesopathy 63.76 11.13 147 326953 9491 64162141
Wheelchair user 63.42 11.13 97 327003 4575 64167057
Chills 62.52 11.13 423 326677 136841 64034791
Haemoptysis 62.34 11.13 95 327005 48953 64122679
Onychomadesis 62.23 11.13 75 327025 2809 64168823
Product use in unapproved indication 62.17 11.13 1249 325851 175369 63996263
Neck mass 62.15 11.13 89 327011 3955 64167677
Hypophosphataemia 62.02 11.13 3 327097 14717 64156915
Gastrooesophageal reflux disease 61.91 11.13 215 326885 82928 64088704
Withdrawal syndrome 61.70 11.13 21 327079 23471 64148161
Muscle twitching 61.49 11.13 11 327089 18987 64152645
Cyanosis 61.41 11.13 18 327082 22137 64149495
Terminal state 61.37 11.13 93 327007 4351 64167281
Cardiogenic shock 61.16 11.13 45 327055 32382 64139250
Onychomycosis 61.06 11.13 101 326999 5095 64166537
Subacute cutaneous lupus erythematosus 60.96 11.13 76 327024 2949 64168683
Product administration error 60.94 11.13 32 327068 27611 64144021
Vertigo 60.92 11.13 130 326970 58881 64112751
Clostridium difficile colitis 60.77 11.13 31 327069 27192 64144440
Depression 60.66 11.13 615 326485 182676 63988956
Night sweats 60.18 11.13 350 326750 35696 64135936
Cardiac disorder 60.12 11.13 120 326980 55696 64115936
Flushing 59.49 11.13 202 326898 78446 64093186
Incorrect dose administered 59.34 11.13 138 326962 60627 64111005
Tenderness 59.04 11.13 226 326874 19376 64152256
Presbyacusis 58.92 11.13 69 327031 2506 64169126
Myoclonus 58.51 11.13 27 327073 25091 64146541
Haemorrhage intracranial 58.29 11.13 24 327076 23860 64147772
Paraesthesia 58.10 11.13 421 326679 134101 64037531
Myelosuppression 58.07 11.13 24 327076 23806 64147826
Fear of injection 57.85 11.13 106 326994 5806 64165826
Ileus 57.82 11.13 22 327078 22944 64148688
Hyperthyroidism 57.82 11.13 11 327089 18168 64153464
Extrapyramidal disorder 57.76 11.13 14 327086 19538 64152094
Coordination abnormal 57.30 11.13 5 327095 14959 64156673
Abdominal distension 57.15 11.13 271 326829 95723 64075909
Hypothermia 57.15 11.13 15 327085 19841 64151791
Limb discomfort 57.04 11.13 281 326819 26894 64144738
Ovarian neoplasm 56.94 11.13 36 327064 547 64171085
Flatulence 56.93 11.13 58 327042 35608 64136024
Tachypnoea 56.76 11.13 32 327068 26539 64145093
Blood triglycerides increased 56.74 11.13 13 327087 18853 64152779
Inappropriate antidiuretic hormone secretion 56.70 11.13 21 327079 22268 64149364
Poisoning 56.70 11.13 20 327080 21859 64149773
White blood cell count increased 56.70 11.13 160 326940 65854 64105778
Angina pectoris 56.64 11.13 88 327012 44993 64126639
Osteoporotic fracture 56.50 11.13 80 327020 3518 64168114
Delirium 56.32 11.13 172 326928 69022 64102610
Multiple fractures 56.23 11.13 106 326994 5934 64165698
Intestinal sepsis 56.19 11.13 37 327063 605 64171027
Electrolyte imbalance 55.97 11.13 29 327071 25214 64146418
Angioedema 55.22 11.13 147 326953 61674 64109958
Hypervolaemia 54.84 11.13 68 327032 38217 64133415
Haematochezia 54.73 11.13 164 326936 66209 64105423
Gastritis 54.69 11.13 82 327018 42536 64129096
Neck pain 54.62 11.13 514 326586 61019 64110613
Bone swelling 54.59 11.13 47 327053 1170 64170462
Deafness transitory 54.58 11.13 40 327060 783 64170849
Psychotic disorder 54.33 11.13 57 327043 34521 64137111
Muscle spasticity 54.22 11.13 197 326903 16472 64155160
Myocardial ischaemia 54.15 11.13 25 327075 23226 64148406
Urinary incontinence 54.14 11.13 62 327038 36089 64135543
Paranoia 53.95 11.13 9 327091 16343 64155289
Device dislocation 53.80 11.13 20 327080 21158 64150474
Bone disorder 53.62 11.13 197 326903 16562 64155070
Pancreatitis acute 53.51 11.13 84 327016 42771 64128861
Dry skin 53.40 11.13 112 326988 51049 64120583
Full blood count decreased 53.03 11.13 24 327076 22558 64149074
Hypophagia 52.93 11.13 74 327026 39513 64132119
Poisoning deliberate 52.91 11.13 4 327096 13454 64158178
Cataract 52.61 11.13 442 326658 50820 64120812
Chest discomfort 52.27 11.13 359 326741 115747 64055885
Dialysis 52.22 11.13 11 327089 16909 64154723
Spinal column injury 51.61 11.13 55 327045 1797 64169835
Neck deformity 51.56 11.13 53 327047 1659 64169973
Ischaemic stroke 51.34 11.13 43 327057 28992 64142640
Pleural thickening 51.31 11.13 66 327034 2644 64168988
Haemodialysis 50.90 11.13 12 327088 17065 64154567
Second primary malignancy 50.46 11.13 3 327097 12334 64159298
Intestinal obstruction 50.37 11.13 66 327034 36220 64135412
Tuberculosis 50.20 11.13 163 326937 12875 64158757
Aspiration 50.06 11.13 12 327088 16873 64154759
Injection site reaction 49.84 11.13 406 326694 46258 64125374
Blood potassium decreased 49.67 11.13 80 327020 40319 64131313
Hypoalbuminaemia 49.65 11.13 14 327086 17660 64153972
Cholestasis 49.60 11.13 95 327005 44777 64126855
Infusion site reaction 49.58 11.13 57 327043 2029 64169603
Ataxia 49.52 11.13 25 327075 22059 64149573
Neoplasm malignant 49.50 11.13 252 326848 24436 64147196
Pleural fibrosis 49.32 11.13 80 327020 3970 64167662
Miosis 49.29 11.13 5 327095 13261 64158371
Thyroid neoplasm 49.20 11.13 64 327036 2593 64169039
Erectile dysfunction 48.95 11.13 4 327096 12623 64159009
Wheezing 48.25 11.13 227 326873 80352 64091280
Palpitations 48.07 11.13 321 326779 104167 64067465
Pemphigoid 47.97 11.13 5 327095 12981 64158651
Dry eye 47.94 11.13 281 326819 28738 64142894
Mycotic allergy 47.75 11.13 40 327060 958 64170674
Hepatic enzyme abnormal 47.71 11.13 97 327003 5742 64165890
Hepatocellular injury 47.24 11.13 99 327001 45136 64126496
Swollen tongue 47.07 11.13 65 327035 34889 64136743
Blood sodium decreased 46.99 11.13 48 327052 29434 64142198
Mental disorder 46.96 11.13 39 327061 26406 64145226
Graft versus host disease 46.93 11.13 7 327093 13806 64157826
Obstructive airways disorder 46.62 11.13 30 327070 23155 64148477
Alanine aminotransferase abnormal 46.60 11.13 106 326994 6782 64164850
Pulmonary congestion 46.53 11.13 32 327068 23848 64147784
Septic shock 46.48 11.13 328 326772 105109 64066523
Glycosylated haemoglobin increased 46.30 11.13 12 327088 16007 64155625
Chronic obstructive pulmonary disease 46.25 11.13 194 326906 70854 64100778
Dementia 45.83 11.13 24 327076 20742 64150890
Anti-cyclic citrullinated peptide antibody 45.69 11.13 45 327055 1337 64170295
Hepatic encephalopathy 45.54 11.13 25 327075 21041 64150591
Drug use disorder 45.30 11.13 97 327003 5957 64165675
Muscle rigidity 45.23 11.13 16 327084 17457 64154175
Anger 45.10 11.13 12 327088 15729 64155903
Blood pressure diastolic abnormal 45 11.13 148 326952 11769 64159863
Acute coronary syndrome 44.60 11.13 21 327079 19289 64152343
Presyncope 44.55 11.13 68 327032 35021 64136611
Drug specific antibody 44.42 11.13 54 327046 2041 64169591
Coagulopathy 44.36 11.13 58 327042 31862 64139770
Head injury 44.30 11.13 61 327039 32781 64138851
Accidental exposure to product 44.25 11.13 41 327059 26323 64145309
Shock haemorrhagic 44.12 11.13 15 327085 16776 64154856
Agranulocytosis 43.97 11.13 79 327021 38150 64133482
Malnutrition 43.87 11.13 21 327079 19104 64152528
International normalised ratio fluctuation 43.80 11.13 64 327036 2897 64168735
Acquired pigmented retinopathy 43.79 11.13 11 327089 4 64171628
Blood pressure systolic abnormal 43.56 11.13 130 326970 9812 64161820
Full blood count abnormal 43.52 11.13 52 327048 29705 64141927
Pericardial effusion 43.48 11.13 83 327017 39171 64132461
Speech disorder 43.40 11.13 115 326985 48326 64123306
Mydriasis 43.25 11.13 12 327088 15300 64156332
Limb deformity 43.14 11.13 68 327032 3293 64168339
Joint lock 43.06 11.13 62 327038 2769 64168863
Cellulitis 42.94 11.13 288 326812 93369 64078263
Urine output decreased 42.87 11.13 15 327085 16477 64155155
Dystonia 42.84 11.13 21 327079 18844 64152788
Subarachnoid haemorrhage 42.67 11.13 20 327080 18418 64153214
Renal tubular necrosis 42.59 11.13 30 327070 22080 64149552
Delusion 42.53 11.13 19 327081 17995 64153637
Lupus-like syndrome 42.42 11.13 119 326981 8672 64162960
Nervous system disorder 42.27 11.13 33 327067 23045 64148587
Complication associated with device 42.26 11.13 12 327088 15068 64156564
Shock 42.23 11.13 81 327019 38159 64133473
Lupus vasculitis 42.20 11.13 28 327072 464 64171168
Gastrointestinal pain 42.07 11.13 108 326992 7466 64164166
Glomerular filtration rate decreased 41.19 11.13 24 327076 19548 64152084
Brain oedema 41.16 11.13 31 327069 22044 64149588
Parkinsonism 41.10 11.13 11 327089 14362 64157270
Aplastic anaemia 41.06 11.13 10 327090 13910 64157722
Faeces discoloured 40.89 11.13 42 327058 25687 64145945
Pneumonia viral 40.85 11.13 109 326991 7713 64163919
Aspartate aminotransferase increased 40.83 11.13 399 326701 119389 64052243
Dyspnoea exertional 40.53 11.13 214 326886 73516 64098116
Hair follicle tumour benign 40.35 11.13 26 327074 409 64171223
Thrombotic microangiopathy 40.22 11.13 17 327083 16638 64154994
Antibody test positive 40.00 11.13 55 327045 2352 64169280
Blood glucose decreased 39.96 11.13 35 327065 23088 64148544
Hemiparesis 39.63 11.13 56 327044 29771 64141861
Extremity contracture 39.63 11.13 45 327055 1580 64170052
Myelodysplastic syndrome 39.48 11.13 49 327051 27530 64144102
Metastases to lung 39.48 11.13 14 327086 15250 64156382
Lipase increased 39.37 11.13 12 327088 14390 64157242
Lower gastrointestinal haemorrhage 39.23 11.13 11 327089 13928 64157704
Salivary hypersecretion 39.23 11.13 7 327093 12106 64159526
Pulmonary thrombosis 39.16 11.13 130 326970 10388 64161244
Hypersomnia 38.98 11.13 26 327074 19691 64151941
Hyperammonaemia 38.78 11.13 3 327097 9901 64161731
Laryngeal disorder 38.78 11.13 34 327066 868 64170764
Pustular psoriasis 38.43 11.13 73 327027 4110 64167522
Histoplasmosis disseminated 38.36 11.13 49 327051 1949 64169683
Overlap syndrome 38.36 11.13 31 327069 705 64170927
Retinitis 38.26 11.13 50 327050 2035 64169597
Transfusion 37.97 11.13 22 327078 17972 64153660
Neutrophil count increased 37.89 11.13 43 327057 25131 64146501
Acute hepatic failure 37.80 11.13 46 327054 26066 64145566
Transaminases abnormal 37.63 11.13 31 327069 725 64170907
Petechiae 37.59 11.13 24 327076 18602 64153030
Polyuria 37.45 11.13 9 327091 12634 64158998
Leukocytosis 37.42 11.13 85 327015 37655 64133977
Labelled drug-drug interaction medication error 37.40 11.13 34 327066 22028 64149604
Metastases to central nervous system 37.30 11.13 12 327088 13900 64157732
Arteriosclerosis coronary artery 37.26 11.13 16 327084 15513 64156119
Exostosis 37.05 11.13 135 326965 11303 64160329
Lyme disease 36.89 11.13 53 327047 2362 64169270
Underdose 36.86 11.13 46 327054 25783 64145849
Troponin increased 36.74 11.13 16 327084 15383 64156249
Cutaneous vasculitis 36.68 11.13 93 327007 6380 64165252
Prothrombin time prolonged 36.54 11.13 17 327083 15724 64155908
Alanine aminotransferase increased 36.48 11.13 491 326609 138540 64033092
Brain injury 36.39 11.13 4 327096 9961 64161671
Wrist surgery 36.36 11.13 30 327070 703 64170929
Bloody discharge 36.19 11.13 41 327059 1436 64170196
Hypertensive crisis 36.16 11.13 24 327076 18224 64153408
Psychomotor hyperactivity 36.12 11.13 14 327086 14437 64157195
Myopathy toxic 36.10 11.13 32 327068 829 64170803
Live birth 36.09 11.13 132 326968 11072 64160560
Bronchospasm 36.06 11.13 34 327066 21648 64149984
Nightmare 36.01 11.13 32 327068 20961 64150671
Acidosis 35.81 11.13 23 327077 17772 64153860
Restrictive cardiomyopathy 35.79 11.13 32 327068 839 64170793
Cough 35.78 11.13 1214 325886 300934 63870698
Osteopenia 35.74 11.13 165 326935 15375 64156257
Infective pulmonary exacerbation of cystic fibrosis 35.73 11.13 8 327092 11788 64159844
Pulmonary toxicity 35.68 11.13 110 326990 8451 64163181
Mania 35.68 11.13 19 327081 16267 64155365
Sinus bradycardia 35.67 11.13 38 327062 22855 64148777
Infiltration anaesthesia 35.63 11.13 17 327083 142 64171490
Antinuclear antibody positive 35.63 11.13 90 327010 6160 64165472
Hypovolaemia 35.53 11.13 17 327083 15469 64156163
Hypothyroidism 35.53 11.13 97 327003 40360 64131272
Weight increased 35.45 11.13 1370 325730 211978 63959654
Phospholipidosis 35.45 11.13 16 327084 116 64171516
Cytology abnormal 35.45 11.13 22 327078 323 64171309
Ankle operation 35.36 11.13 34 327066 980 64170652
Bronchitis chronic 35.36 11.13 68 327032 3864 64167768
Abdominal pain lower 34.87 11.13 50 327050 26419 64145213
Drug resistance 34.85 11.13 79 327021 35023 64136609
Haematotoxicity 34.80 11.13 11 327089 12885 64158747
Juvenile idiopathic arthritis 34.78 11.13 67 327033 3812 64167820
Hypocalcaemia 34.54 11.13 103 326997 41650 64129982
Asphyxia 34.53 11.13 4 327096 9562 64162070
Polyneuropathy 34.51 11.13 30 327070 19864 64151768
Multiple allergies 34.49 11.13 85 327015 5729 64165903
Coeliac disease 34.47 11.13 99 327001 7313 64164319
Mental impairment 34.45 11.13 20 327080 16323 64155309
Peritonitis 34.23 11.13 46 327054 24977 64146655
Arteriosclerosis 34.09 11.13 19 327081 15858 64155774
Lupus myocarditis 34.09 11.13 14 327086 78 64171554
Stevens-Johnson syndrome 34.07 11.13 77 327023 34172 64137460
Medication error 34.05 11.13 134 326966 49832 64121800
End stage renal disease 34.04 11.13 6 327094 10469 64161163
Hallucination, auditory 33.94 11.13 22 327078 16917 64154715
Haemorrhagic stroke 33.91 11.13 5 327095 9946 64161686
Blood magnesium decreased 33.89 11.13 14 327086 13891 64157741
Gait inability 33.26 11.13 345 326755 42023 64129609
Hypofibrinogenaemia 33.19 11.13 43 327057 1735 64169897
Incontinence 33.15 11.13 10 327090 12071 64159561
Metastases to lymph nodes 33.14 11.13 3 327097 8714 64162918
Blood magnesium increased 32.98 11.13 59 327041 3172 64168460
Anal incontinence 32.89 11.13 18 327082 15178 64156454
Suspected suicide 32.84 11.13 3 327097 8651 64162981
Acute pulmonary oedema 32.70 11.13 12 327088 12797 64158835
Personality change 32.55 11.13 3 327097 8590 64163042
Drug level decreased 32.52 11.13 9 327091 11494 64160138
Oesophagitis 32.49 11.13 37 327063 21593 64150039
Bacteraemia 32.42 11.13 54 327046 26857 64144775
Drug specific antibody present 32.33 11.13 77 327023 5077 64166555
Feeling hot 32.05 11.13 121 326979 45542 64126090
Carpal tunnel syndrome 32.04 11.13 162 326938 15666 64155966
Victim of child abuse 31.89 11.13 30 327070 841 64170791
Swelling face 31.81 11.13 173 326927 58993 64112639
Granulocytopenia 31.79 11.13 7 327093 10433 64161199
Device issue 31.63 11.13 41 327059 22607 64149025
Pathogen resistance 31.60 11.13 12 327088 12531 64159101
Ejection fraction decreased 31.53 11.13 61 327039 28646 64142986
Clostridium difficile infection 31.53 11.13 87 327013 36076 64135556
Anhedonia 31.51 11.13 15 327085 13691 64157941
Sinus tachycardia 31.50 11.13 73 327027 32115 64139517
Deafness neurosensory 31.47 11.13 87 327013 6287 64165345
Diabetes mellitus inadequate control 31.46 11.13 37 327063 21284 64150348
Tenosynovitis stenosans 31.40 11.13 44 327056 1916 64169716
Vascular access complication 31.29 11.13 33 327067 1065 64170567
Respiratory disorder 31.22 11.13 300 326800 35811 64135821
Mesenteritis 31.16 11.13 17 327083 193 64171439
Activated partial thromboplastin time prolonged 31.14 11.13 13 327087 12818 64158814
Toxic encephalopathy 31.08 11.13 6 327094 9809 64161823
Butterfly rash 31.00 11.13 34 327066 1148 64170484
Synovial fluid analysis 30.95 11.13 39 327061 1530 64170102
Asthma 30.86 11.13 321 326779 94904 64076728
Foot operation 30.71 11.13 67 327033 4168 64167464
Faecaloma 30.70 11.13 6 327094 9722 64161910
Hyperuricaemia 30.69 11.13 7 327093 10184 64161448
Optical coherence tomography abnormal 30.63 11.13 9 327091 13 64171619
Stress at work 30.48 11.13 31 327069 958 64170674
Transplant rejection 30.48 11.13 26 327074 17375 64154257
Cushingoid 30.13 11.13 96 327004 7507 64164125
Type 2 diabetes mellitus 30.10 11.13 284 326816 33736 64137896
Drug level increased 30.02 11.13 82 327018 34114 64137518
Duodenal ulcer 29.96 11.13 18 327082 14417 64157215
Feeling cold 29.95 11.13 46 327054 23632 64148000
Metabolic encephalopathy 29.88 11.13 3 327097 8022 64163610
Nail disorder 29.83 11.13 104 326996 8520 64163112
Intestinal polyp 29.81 11.13 40 327060 1671 64169961
Feeling abnormal 29.79 11.13 487 326613 133115 64038517
Failure to thrive 29.68 11.13 8 327092 10396 64161236
Pollakiuria 29.67 11.13 73 327027 31457 64140175
Maternal exposure timing unspecified 29.66 11.13 51 327049 2656 64168976
Renal injury 29.63 11.13 21 327079 15408 64156224
Cholangitis 29.53 11.13 9 327091 10793 64160839
Post procedural haemorrhage 29.52 11.13 13 327087 12418 64159214
Pulmonary hypertension 29.20 11.13 116 326984 43023 64128609
Gastric haemorrhage 29.14 11.13 16 327084 13465 64158167
Oliguria 29.11 11.13 19 327081 14557 64157075
Mood altered 29.08 11.13 23 327077 15956 64155676
Cholecystitis 29.05 11.13 34 327066 19602 64152030
Body temperature increased 28.99 11.13 299 326801 36367 64135265
Latent tuberculosis 28.98 11.13 51 327049 2706 64168926
Colitis ischaemic 28.88 11.13 16 327084 13398 64158234
Cutaneous coccidioidomycosis 28.81 11.13 9 327091 18 64171614
Eosinophil count increased 28.73 11.13 18 327082 14094 64157538
Diffuse alopecia 28.65 11.13 24 327076 575 64171057
Bursitis 28.64 11.13 197 326903 21288 64150344
No adverse event 28.63 11.13 245 326855 28316 64143316
Anovulatory cycle 28.60 11.13 13 327087 96 64171536
Prostatic specific antigen increased 28.51 11.13 5 327095 8755 64162877
Mycobacterium tuberculosis complex test positive 28.50 11.13 43 327057 2004 64169628
Peripheral sensory neuropathy 28.47 11.13 11 327089 11367 64160265
Cartilage atrophy 28.46 11.13 15 327085 158 64171474
Fracture delayed union 28.06 11.13 42 327058 1943 64169689
Disease susceptibility 28.03 11.13 17 327083 239 64171393
Vasculitic rash 27.97 11.13 42 327058 1949 64169683
Depressed mood 27.93 11.13 110 326990 40902 64130730
Large intestine polyp 27.92 11.13 10 327090 10827 64160805
Anuria 27.88 11.13 33 327067 18931 64152701
Diarrhoea haemorrhagic 27.86 11.13 11 327089 11216 64160416
Muscular weakness 27.79 11.13 466 326634 126872 64044760
Face oedema 27.74 11.13 52 327048 24709 64146923
Kidney transplant rejection 27.73 11.13 7 327093 9504 64162128
Ventricular fibrillation 27.72 11.13 49 327051 23811 64147821
Pulseless electrical activity 27.71 11.13 15 327085 12724 64158908
Soft tissue disorder 27.46 11.13 55 327045 3221 64168411
Hypercalcaemia 27.17 11.13 261 326839 31155 64140477
Skin exfoliation 27.13 11.13 126 326974 44759 64126873
Device difficult to use 27.08 11.13 8 327092 9790 64161842
Drug tolerance 27.07 11.13 80 327020 6005 64165627
Toxic epidermal necrolysis 27.06 11.13 97 327003 37069 64134563
Immune thrombocytopenia 27.02 11.13 22 327078 15044 64156588
Oedema 26.98 11.13 317 326783 91618 64080014
Body tinea 26.88 11.13 33 327067 1260 64170372
Multiple sclerosis 26.75 11.13 34 327066 18907 64152725
Supraventricular tachycardia 26.64 11.13 34 327066 18873 64152759
Sleep apnoea syndrome 26.59 11.13 71 327029 29761 64141871
Wound infection 26.57 11.13 147 326953 14717 64156915
Dyslipidaemia 26.56 11.13 7 327093 9235 64162397
Sudden death 26.43 11.13 38 327062 20058 64151574
Product prescribing error 26.38 11.13 91 327009 35178 64136454
Smear cervix abnormal 26.37 11.13 45 327055 2329 64169303
Coronary artery stenosis 26.34 11.13 12 327088 11236 64160396
Hyperthermia 26.31 11.13 24 327076 15526 64156106
Staphylococcal infection 26.26 11.13 150 326950 50528 64121104
Red cell distribution width decreased 26.20 11.13 30 327070 1063 64170569
Lip swelling 26.18 11.13 79 327021 31828 64139804
C-reactive protein decreased 26.04 11.13 42 327058 2074 64169558
Cytopenia 26.04 11.13 24 327076 15447 64156185
Pancreatic carcinoma 26.01 11.13 10 327090 10363 64161269
Post transplant lymphoproliferative disorder 26.00 11.13 8 327092 9536 64162096
Cold sweat 25.99 11.13 27 327073 16428 64155204
Infection reactivation 25.96 11.13 41 327059 1989 64169643
Device occlusion 25.79 11.13 9 327091 9904 64161728
Mass excision 25.71 11.13 17 327083 280 64171352
Peritonitis bacterial 25.71 11.13 7 327093 9036 64162596
Blood albumin decreased 25.65 11.13 42 327058 21031 64150601
Pneumonitis 25.60 11.13 150 326950 50215 64121417
Therapy cessation 25.56 11.13 82 327018 32407 64139225
Ankle arthroplasty 25.41 11.13 27 327073 879 64170753
C-reactive protein 25.38 11.13 28 327072 952 64170680
Secretion discharge 25.31 11.13 124 326976 11840 64159792
Haemodynamic instability 25.25 11.13 23 327077 14889 64156743
Diplopia 25.16 11.13 62 327038 26703 64144929
Hepatic necrosis 25.16 11.13 6 327094 8467 64163165
Ocular toxicity 25.10 11.13 23 327077 623 64171009
Retinal degeneration 25.10 11.13 29 327071 1038 64170594
Right ventricular failure 25.03 11.13 44 327056 21427 64150205
Mean platelet volume decreased 25.01 11.13 37 327063 1694 64169938
Ageusia 24.99 11.13 20 327080 13793 64157839
Leukoencephalopathy 24.94 11.13 3 327097 6964 64164668
Enterocolitis 24.92 11.13 15 327085 12003 64159629
Ileus paralytic 24.91 11.13 6 327094 8409 64163223
Aplasia 24.87 11.13 3 327097 6950 64164682
Angina unstable 24.86 11.13 25 327075 15442 64156190
Weight decreased 24.79 11.13 1190 325910 284549 63887083
Device leakage 24.26 11.13 6 327094 8260 64163372
Memory impairment 24.16 11.13 298 326802 85384 64086248
Retching 24.13 11.13 25 327075 15231 64156401
Arthritis bacterial 24.12 11.13 91 327009 7748 64163884
Chromaturia 24.02 11.13 49 327051 22562 64149070
Gout 23.96 11.13 45 327055 21368 64150264
Respiratory depression 23.90 11.13 52 327048 23391 64148241
Respiratory acidosis 23.89 11.13 10 327090 9845 64161787
Heart rate irregular 23.86 11.13 66 327034 27347 64144285
Taste disorder 23.81 11.13 9 327091 9424 64162208
Frequent bowel movements 23.70 11.13 35 327065 18270 64153362
Joint dislocation 23.67 11.13 118 326982 11347 64160285
Incoherent 23.30 11.13 4 327096 7114 64164518
Limb operation 23.29 11.13 47 327053 2767 64168865
Lung infiltration 23.28 11.13 44 327056 20845 64150787
Eyelid oedema 23.20 11.13 17 327083 12262 64159370
Precancerous cells present 23.20 11.13 27 327073 974 64170658
Pneumonia fungal 23.20 11.13 8 327092 8869 64162763
Proctalgia 23.15 11.13 5 327095 7554 64164078
Needle issue 23.14 11.13 9 327091 9263 64162369
Large intestine perforation 23.11 11.13 18 327082 12586 64159046
Blood pressure fluctuation 22.84 11.13 380 326720 51491 64120141
Gastritis erosive 22.84 11.13 10 327090 9585 64162047
Infective tenosynovitis 22.56 11.13 16 327084 297 64171335
Extradural abscess 22.54 11.13 29 327071 1162 64170470
BK virus infection 22.51 11.13 5 327095 7407 64164225
Cholecystitis acute 22.43 11.13 15 327085 11345 64160287
Cardiac failure acute 22.40 11.13 30 327070 16314 64155318
Bladder cancer 22.34 11.13 14 327086 10960 64160672
Ketoacidosis 22.15 11.13 4 327096 6859 64164773
Coma scale abnormal 22.13 11.13 6 327094 7768 64163864
Partial seizures 22.04 11.13 5 327095 7302 64164330
Ear infection 22.03 11.13 198 326902 23206 64148426
Heart rate increased 21.89 11.13 360 326740 98315 64073317
Adenovirus infection 21.82 11.13 5 327095 7250 64164382
Panic attack 21.75 11.13 46 327054 20907 64150725
Blood loss anaemia 21.71 11.13 23 327077 13869 64157763
Amylase increased 21.66 11.13 11 327089 9674 64161958
Scleritis 21.59 11.13 47 327053 2919 64168713
Pneumocystis jirovecii pneumonia 21.56 11.13 70 327030 27564 64144068
Hospice care 21.49 11.13 6 327094 7619 64164013
Catatonia 21.47 11.13 6 327094 7614 64164018
Eye swelling 21.43 11.13 51 327049 22230 64149402
Abnormal dreams 21.37 11.13 13 327087 10343 64161289
Hypoxic-ischaemic encephalopathy 21.36 11.13 5 327095 7147 64164485
Hemiplegia 21.26 11.13 20 327080 12748 64158884
Middle lobe syndrome 21.22 11.13 8 327092 34 64171598
Anal abscess 20.99 11.13 6 327094 7502 64164130
Epigastric discomfort 20.90 11.13 79 327021 6732 64164900
Diabetic eye disease 20.79 11.13 12 327088 153 64171479
Chorioretinitis 20.73 11.13 21 327079 646 64170986
Device malfunction 20.67 11.13 36 327064 17597 64154035
Androgenetic alopecia 20.59 11.13 12 327088 156 64171476
Intestinal ischaemia 20.54 11.13 17 327083 11532 64160100
Pathological fracture 20.48 11.13 10 327090 8995 64162637
Anticoagulation drug level increased 20.41 11.13 21 327079 658 64170974
Device use error 20.40 11.13 4 327096 6467 64165165
Thirst 20.36 11.13 25 327075 14112 64157520
Visual acuity reduced 20.32 11.13 70 327030 27071 64144561
Interstitial lung disease 20.30 11.13 644 326456 97088 64074544
Walking aid user 20.23 11.13 74 327026 6207 64165425
Rash pruritic 20.18 11.13 406 326694 56998 64114634
Pulmonary haemorrhage 20.16 11.13 22 327078 13087 64158545
Prostate cancer 20.10 11.13 44 327056 19751 64151881
Cutaneous lupus erythematosus 20.10 11.13 43 327057 2639 64168993
Cerebral atrophy 20.04 11.13 6 327094 7279 64164353
Inappropriate schedule of product administration 20.04 11.13 338 326762 91948 64079684
Pulmonary arterial hypertension 19.97 11.13 64 327036 25303 64146329
Natural killer-cell leukaemia 19.95 11.13 10 327090 94 64171538
Tendon disorder 19.89 11.13 74 327026 6258 64165374
Hepatitis C 19.86 11.13 16 327084 10999 64160633
Spinal meningioma benign 19.77 11.13 10 327090 96 64171536
Intervertebral disc compression 19.74 11.13 25 327075 986 64170646
Hepatic lesion 19.68 11.13 3 327097 5821 64165811
Nervousness 19.67 11.13 80 327020 29476 64142156
Polydipsia 19.66 11.13 3 327097 5818 64165814
General physical health deterioration 19.61 11.13 842 326258 203583 63968049
Eyelid ptosis 19.60 11.13 12 327088 9513 64162119
Kidney duplex 19.54 11.13 6 327094 11 64171621
Gastric ulcer 19.40 11.13 83 327017 30151 64141481
Urticarial vasculitis 19.39 11.13 17 327083 434 64171198
Femoral neck fracture 19.37 11.13 10 327090 8714 64162918
Skin reaction 19.37 11.13 118 326982 12234 64159398
Refusal of treatment by patient 19.37 11.13 9 327091 8330 64163302
Oral disorder 19.26 11.13 93 327007 8828 64162804
Drug screen positive 19.24 11.13 3 327097 5726 64165906
Infected seroma 19.19 11.13 9 327091 72 64171560
Placenta accreta 19.17 11.13 12 327088 179 64171453
Thyroid disorder 19.17 11.13 113 326987 11579 64160053
Autoimmune haemolytic anaemia 19.16 11.13 6 327094 7070 64164562
Trigger finger 19.12 11.13 50 327050 3495 64168137
Fistula 19.12 11.13 13 327087 9748 64161884
PaO2/FiO2 ratio decreased 19.10 11.13 7 327093 27 64171605
Viral vasculitis 19.08 11.13 11 327089 140 64171492
Double stranded DNA antibody positive 19.07 11.13 16 327084 384 64171248
Skin toxicity 18.98 11.13 5 327095 6597 64165035
Hepatic cancer 18.97 11.13 7 327093 7441 64164191
Antiphospholipid syndrome 18.93 11.13 31 327069 1551 64170081
Myocarditis 18.91 11.13 36 327064 17007 64154625
External auditory canal atresia 18.89 11.13 6 327094 13 64171619
Enteritis 18.87 11.13 20 327080 12057 64159575
Neck surgery 18.79 11.13 30 327070 1469 64170163
Rotator cuff repair 18.79 11.13 30 327070 1469 64170163
Fear 18.75 11.13 47 327053 20124 64151508
Amenorrhoea 18.70 11.13 5 327095 6534 64165098
Cholecystitis chronic 18.69 11.13 12 327088 9275 64162357
Toxic skin eruption 18.66 11.13 44 327056 19240 64152392
Left ventricular dysfunction 18.64 11.13 36 327064 16918 64154714
Ankylosing spondylitis 18.62 11.13 87 327013 8147 64163485
Klebsiella infection 18.59 11.13 24 327076 13257 64158375
Retinal coloboma 18.58 11.13 6 327094 14 64171618
Iris coloboma 18.58 11.13 6 327094 14 64171618
Bronchopleural fistula 18.58 11.13 19 327081 591 64171041
Stress cardiomyopathy 18.58 11.13 12 327088 9245 64162387
Cerebral ischaemia 18.56 11.13 14 327086 9948 64161684
Gastric cancer 18.51 11.13 5 327095 6488 64165144
Blood pressure systolic increased 18.48 11.13 353 326747 49100 64122532
Rash macular 18.48 11.13 60 327040 23625 64148007
Hepatomegaly 18.43 11.13 36 327064 16846 64154786
Neuropsychiatric lupus 18.42 11.13 11 327089 150 64171482
Metabolic disorder 18.36 11.13 8 327092 7689 64163943
Drug reaction with eosinophilia and systemic symptoms 18.29 11.13 181 326919 54036 64117596
Systemic inflammatory response syndrome 18.29 11.13 15 327085 10220 64161412
Photosensitivity reaction 18.27 11.13 156 326944 18017 64153615
Renal tubular disorder 18.26 11.13 4 327096 5983 64165649
Histoplasmosis 18.22 11.13 35 327065 1987 64169645
Gingivitis 18.20 11.13 8 327092 7651 64163981
Electrocardiogram ST segment elevation 18.20 11.13 7 327093 7252 64164380
Allergy to vaccine 18.17 11.13 11 327089 154 64171478
Hyperventilation 18.16 11.13 6 327094 6834 64164798
Shoulder operation 18.05 11.13 36 327064 2102 64169530
Dactylitis 18.03 11.13 34 327066 1904 64169728
Cranial nerve injury 18.02 11.13 6 327094 16 64171616
Adenoiditis 17.99 11.13 7 327093 33 64171599
Cytomegalovirus viraemia 17.98 11.13 17 327083 10811 64160821
Decubitus ulcer 17.89 11.13 25 327075 13354 64158278
Product substitution issue 17.89 11.13 40 327060 17821 64153811
Anaphylactic shock 17.82 11.13 86 327014 30242 64141390
Cardiomegaly 17.79 11.13 61 327039 23623 64148009
Nausea 17.76 11.13 3617 323483 782183 63389449
Apnoea 17.74 11.13 16 327084 10406 64161226
Atrioventricular block first degree 17.65 11.13 17 327083 10717 64160915
Pulmonary mass 17.65 11.13 193 326907 23823 64147809
Hepatitis fulminant 17.57 11.13 5 327095 6269 64165363
Peripheral coldness 17.56 11.13 26 327074 13558 64158074
Micturition urgency 17.52 11.13 16 327084 10343 64161289
Menopausal symptoms 17.48 11.13 30 327070 1560 64170072
Obesity 17.37 11.13 170 326930 20392 64151240
Sensory disturbance 17.35 11.13 25 327075 13183 64158449
Back disorder 17.32 11.13 98 327002 9892 64161740
Haemorrhoids 17.23 11.13 63 327037 23938 64147694
Erythema 17.22 11.13 774 326326 186296 63985336
Urosepsis 17.21 11.13 56 327044 22038 64149594
Blood uric acid increased 17.19 11.13 10 327090 8153 64163479
Hypovolaemic shock 17.19 11.13 16 327084 10250 64161382
Transaminases increased 17.16 11.13 144 326956 44450 64127182
Gastric ulcer haemorrhage 17.12 11.13 10 327090 8133 64163499
Cachexia 17.11 11.13 13 327087 9204 64162428
Exposure to toxic agent 17.08 11.13 5 327095 6154 64165478
Diffuse idiopathic skeletal hyperostosis 17.04 11.13 7 327093 39 64171593
Hypotonia 17.04 11.13 19 327081 11193 64160439
Oral discomfort 16.99 11.13 86 327014 8320 64163312
Intrauterine infection 16.96 11.13 8 327092 65 64171567
Visual field defect 16.93 11.13 84 327016 8062 64163570
Benign prostatic hyperplasia 16.92 11.13 13 327087 9152 64162480
Therapy interrupted 16.88 11.13 49 327051 19987 64151645
Haemoglobin increased 16.86 11.13 3 327097 5198 64166434
Tongue disorder 16.84 11.13 112 326988 11968 64159664
Central nervous system lupus 16.80 11.13 13 327087 277 64171355
Upper limb fracture 16.77 11.13 131 326969 14735 64156897
Joint space narrowing 16.77 11.13 12 327088 226 64171406
Oral herpes 16.73 11.13 179 326921 21973 64149659
Blood thyroid stimulating hormone increased 16.66 11.13 9 327091 7645 64163987
Osteosclerosis 16.64 11.13 47 327053 3439 64168193
Impaired quality of life 16.61 11.13 71 327029 6400 64165232
Erysipelas 16.61 11.13 13 327087 9068 64162564
Hypoacusis 16.60 11.13 71 327029 25796 64145836
Incorrect product administration duration 16.58 11.13 15 327085 9743 64161889
Bradyphrenia 16.54 11.13 14 327086 9392 64162240
Intermenstrual bleeding 16.51 11.13 3 327097 5122 64166510
Cardiac failure chronic 16.47 11.13 13 327087 9028 64162604
Hypoventilation 16.43 11.13 5 327095 6001 64165631
Mass 16.36 11.13 133 326967 15143 64156489
Symptom masked 16.35 11.13 25 327075 1179 64170453
Staphylococcal bacteraemia 16.34 11.13 17 327083 10338 64161294
Hypertransaminasaemia 16.28 11.13 76 327024 7115 64164517
Thrombosis in device 16.27 11.13 3 327097 5068 64166564
Breast cancer metastatic 16.25 11.13 8 327092 7161 64164471
Atelectasis 16.20 11.13 77 327023 27189 64144443
Heart rate abnormal 16.11 11.13 3 327097 5032 64166600
Hypernatraemia 16.08 11.13 23 327077 12166 64159466
Cerebellar syndrome 16.03 11.13 3 327097 5013 64166619
Bacterial sepsis 15.90 11.13 9 327091 7448 64164184
Cyst 15.87 11.13 110 326990 11917 64159715
Occult blood positive 15.86 11.13 6 327094 6281 64165351
Gastrointestinal perforation 15.80 11.13 4 327096 5420 64166212
Oxygen saturation decreased 15.79 11.13 418 326682 106758 64064874
Adjustment disorder with depressed mood 15.73 11.13 37 327063 2420 64169212
Rash erythematous 15.73 11.13 164 326936 48469 64123163
External ear disorder 15.71 11.13 8 327092 78 64171554
Retinal haemorrhage 15.67 11.13 9 327091 7389 64164243
Blood potassium increased 15.66 11.13 73 327027 25907 64145725
Coronary artery bypass 15.62 11.13 5 327095 5810 64165822
Drug level below therapeutic 15.62 11.13 9 327091 7375 64164257
Lupus enteritis 15.60 11.13 7 327093 50 64171582
Portal hypertension 15.58 11.13 6 327094 6213 64165419
Atrioventricular block 15.53 11.13 23 327077 11992 64159640
Hydronephrosis 15.53 11.13 30 327070 14095 64157537
Mean cell volume decreased 15.51 11.13 46 327054 3460 64168172
Immobile 15.44 11.13 66 327034 5949 64165683
Staphylococcal sepsis 15.43 11.13 26 327074 12873 64158759
Hypercapnia 15.41 11.13 10 327090 7684 64163948
Tendonitis 15.37 11.13 164 326936 20118 64151514
Fundoscopy abnormal 15.37 11.13 7 327093 52 64171580
Muscle haemorrhage 15.36 11.13 5 327095 5748 64165884
Nystagmus 15.34 11.13 14 327086 9054 64162578
Posterior reversible encephalopathy syndrome 15.34 11.13 62 327038 22884 64148748
Peripheral ischaemia 15.32 11.13 12 327088 8366 64163266
Hiccups 15.31 11.13 12 327088 8364 64163268
Iodine allergy 15.28 11.13 16 327084 512 64171120
Urticaria 15.28 11.13 903 326197 146414 64025218
Infection susceptibility increased 15.27 11.13 39 327061 2687 64168945
Injection site pain 15.25 11.13 439 326661 110969 64060663
Larynx irritation 15.25 11.13 9 327091 120 64171512
Carcinoid tumour pulmonary 15.22 11.13 13 327087 320 64171312
Clinical trial participant 15.18 11.13 9 327091 121 64171511
Oral lichen planus 15.17 11.13 18 327082 663 64170969
Speech sound disorder 15.14 11.13 7 327093 54 64171578
Device failure 15.10 11.13 5 327095 5687 64165945
Blood chloride increased 15.08 11.13 3 327097 4800 64166832
Forced expiratory volume decreased 15.06 11.13 8 327092 6859 64164773
Thinking abnormal 15.05 11.13 22 327078 11534 64160098
Overwork 15.04 11.13 7 327093 55 64171577
DNA antibody 14.98 11.13 6 327094 31 64171601
Atrioventricular block second degree 14.94 11.13 7 327093 6447 64165185
Neutrophil/lymphocyte ratio increased 14.93 11.13 4 327096 3 64171629
Coronary artery occlusion 14.84 11.13 30 327070 13861 64157771
Ossicle disorder 14.82 11.13 6 327094 32 64171600
Anaphylactoid reaction 14.79 11.13 3 327097 4735 64166897
Escherichia sepsis 14.78 11.13 9 327091 7156 64164476
Appendicitis 14.76 11.13 29 327071 13540 64158092
Tricuspid valve incompetence 14.75 11.13 41 327059 16962 64154670
Azotaemia 14.69 11.13 10 327090 7492 64164140
Erythematotelangiectatic rosacea 14.59 11.13 5 327095 15 64171617
Somnambulism 14.58 11.13 4 327096 5137 64166495
Duodenitis 14.57 11.13 8 327092 6733 64164899
Snoring 14.54 11.13 3 327097 4679 64166953
Complement factor C4 decreased 14.51 11.13 11 327089 227 64171405
Clostridial infection 14.48 11.13 4 327096 5115 64166517
Vaginal haematoma 14.45 11.13 9 327091 133 64171499
Andersen-Tawil syndrome 14.41 11.13 4 327096 4 64171628
Bacterial test positive 14.37 11.13 8 327092 6682 64164950
Paraesthesia oral 14.34 11.13 28 327072 13103 64158529
Acute generalised exanthematous pustulosis 14.30 11.13 121 326979 13937 64157695
Wrong product administered 14.19 11.13 11 327089 7709 64163923
Hepatocellular carcinoma 14.18 11.13 13 327087 8390 64163242
Faeces soft 14.10 11.13 6 327094 5849 64165783
Eosinophilic pneumonia 14.07 11.13 3 327097 4574 64167058
Gangrene 14.07 11.13 10 327090 7328 64164304
Complement factor C3 decreased 14.06 11.13 12 327088 295 64171337
Colon cancer 14.05 11.13 27 327073 12712 64158920
Apathy 14.03 11.13 22 327078 11210 64160422
Disability assessment scale score increased 13.97 11.13 36 327064 2494 64169138
Haematocrit decreased 13.97 11.13 194 326906 54461 64117171
Ganglioneuroma 13.94 11.13 9 327091 142 64171490
Hiatus hernia 13.93 11.13 53 327047 19904 64151728
Brain natriuretic peptide increased 13.87 11.13 11 327089 7622 64164010
Eye pruritus 13.82 11.13 27 327073 12632 64159000
Procedural complication 13.80 11.13 10 327090 7255 64164377
Pulse absent 13.77 11.13 15 327085 8931 64162701
Blood phosphorus increased 13.74 11.13 4 327096 4942 64166690
Hyperbilirubinaemia 13.73 11.13 58 327042 21147 64150485
Antinuclear antibody 13.68 11.13 14 327086 436 64171196
Paradoxical drug reaction 13.61 11.13 7 327093 6113 64165519
Transient hypogammaglobulinaemia of infancy 13.59 11.13 6 327094 41 64171591
Hypoaesthesia 13.54 11.13 572 326528 138536 64033096
Generalised oedema 13.53 11.13 57 327043 20796 64150836
Human anti-human antibody test 13.51 11.13 13 327087 375 64171257
Therapy change 13.38 11.13 8 327092 6426 64165206
Brain death 13.38 11.13 4 327096 4857 64166775
Cardiac tamponade 13.35 11.13 13 327087 8151 64163481
Papulopustular rosacea 13.31 11.13 5 327095 21 64171611
Blood pH decreased 13.30 11.13 3 327097 4399 64167233
Aortic arteriosclerosis 13.30 11.13 11 327089 7465 64164167
Skin papilloma 13.29 11.13 57 327043 5146 64166486
Elbow operation 13.29 11.13 11 327089 259 64171373
Hypomania 13.29 11.13 6 327094 5648 64165984
Fibrin D dimer increased 13.27 11.13 9 327091 6756 64164876
Dizziness postural 13.27 11.13 18 327082 9734 64161898
Nephropathy toxic 13.23 11.13 45 327055 17469 64154163
Dermatitis acneiform 13.17 11.13 14 327086 8429 64163203
Central nervous system lesion 13.17 11.13 25 327075 11824 64159808
Gingival pain 13.13 11.13 8 327092 6359 64165273
Pleuritic pain 13.11 11.13 78 327022 8018 64163614
Anticipatory anxiety 13.11 11.13 11 327089 264 64171368
Accident 13.11 11.13 69 327031 6777 64164855
Expired product administered 13.09 11.13 7 327093 5980 64165652
Blood chloride decreased 13.09 11.13 11 327089 7405 64164227
Gonorrhoea 12.97 11.13 9 327091 161 64171471
Feeding disorder 12.94 11.13 111 326989 12838 64158794
Respiration abnormal 12.93 11.13 8 327092 6307 64165325
Parainfluenzae virus infection 12.88 11.13 4 327096 4739 64166893
Lupus pancreatitis 12.87 11.13 3 327097 0 64171632
Electrocardiogram abnormal 12.85 11.13 31 327069 13450 64158182
Cytomegalovirus test positive 12.83 11.13 5 327095 5139 64166493
Granulomatous dermatitis 12.83 11.13 12 327088 334 64171298
Amnesia 12.82 11.13 170 326930 48099 64123533
Lacunar infarction 12.80 11.13 6 327094 5526 64166106
Internal haemorrhage 12.78 11.13 12 327088 7655 64163977
Meningitis streptococcal 12.69 11.13 9 327091 167 64171465
Injection site hypersensitivity 12.67 11.13 27 327073 1652 64169980
Tender joint count increased 12.63 11.13 8 327092 122 64171510
Sensory loss 12.63 11.13 20 327080 10149 64161483
Euphoric mood 12.62 11.13 9 327091 6582 64165050
Carotid artery stenosis 12.57 11.13 13 327087 7928 64163704
Rheumatoid factor 12.57 11.13 8 327092 123 64171509
Localised infection 12.57 11.13 219 326881 29942 64141690
Compartment syndrome 12.56 11.13 3 327097 4229 64167403
Knee deformity 12.53 11.13 19 327081 889 64170743
Bradykinesia 12.50 11.13 9 327091 6551 64165081
Lymphocyte percentage decreased 12.48 11.13 4 327096 4645 64166987
Vaginal haemorrhage 12.47 11.13 53 327047 19291 64152341
Influenza like illness 12.43 11.13 229 326871 61473 64110159
Brain herniation 12.40 11.13 9 327091 6524 64165108
Hypergammaglobulinaemia 12.40 11.13 16 327084 643 64170989
Squamous cell carcinoma of skin 12.39 11.13 26 327074 11850 64159782
Connective tissue disorder 12.39 11.13 21 327079 1081 64170551
Initial insomnia 12.38 11.13 7 327093 5797 64165835
Retinal injury 12.38 11.13 11 327089 286 64171346
Acute cutaneous lupus erythematosus 12.37 11.13 12 327088 350 64171282
Blood culture positive 12.32 11.13 13 327087 7855 64163777
Adrenal insufficiency 12.32 11.13 171 326929 22316 64149316
Blood disorder 12.31 11.13 10 327090 6847 64164785
Fracture pain 12.31 11.13 12 327088 352 64171280
Spinal X-ray abnormal 12.30 11.13 5 327095 27 64171605
Infected varicose vein 12.30 11.13 5 327095 27 64171605
Localised oedema 12.29 11.13 11 327089 7180 64164452
Cerebral haematoma 12.26 11.13 11 327089 7174 64164458
Dermatitis exfoliative 12.26 11.13 21 327079 10331 64161301
Congestive cardiomyopathy 12.24 11.13 21 327079 10323 64161309
Sinus node dysfunction 12.21 11.13 10 327090 6818 64164814
Gastrointestinal necrosis 12.21 11.13 5 327095 4987 64166645
Vasculitis 12.20 11.13 143 326957 17952 64153680
Urine analysis abnormal 12.20 11.13 7 327093 5749 64165883
Aspergillosis oral 12.19 11.13 6 327094 54 64171578
International normalised ratio abnormal 12.19 11.13 5 327095 4983 64166649
Performance status decreased 12.13 11.13 6 327094 5358 64166274
Escherichia infection 12.13 11.13 38 327062 15130 64156502
Foetal growth restriction 12.13 11.13 27 327073 1703 64169929
Blindness 12.05 11.13 64 327036 21955 64149677
Pregnancy 11.98 11.13 160 326940 20705 64150927
Injection site mass 11.96 11.13 46 327054 17224 64154408
Renal disorder 11.96 11.13 118 326982 35247 64136385
Liver transplant 11.95 11.13 3 327097 4089 64167543
Coronary arterial stent insertion 11.95 11.13 7 327093 5685 64165947
Hallucinations, mixed 11.94 11.13 8 327092 6044 64165588
Biopsy heart abnormal 11.93 11.13 4 327096 11 64171621
Arthritis salmonella 11.93 11.13 4 327096 11 64171621
Breast cancer 11.91 11.13 211 326889 28937 64142695
Venous thrombosis 11.84 11.13 9 327091 6372 64165260
Depressive symptom 11.84 11.13 4 327096 4492 64167140
Viral load abnormal 11.83 11.13 6 327094 58 64171574
Facial paresis 11.80 11.13 5 327095 4887 64166745
Exercise tolerance decreased 11.79 11.13 13 327087 7697 64163935
Skin discolouration 11.76 11.13 118 326982 35137 64136495
Spinal fusion surgery 11.75 11.13 43 327057 3608 64168024
Brain neoplasm 11.74 11.13 5 327095 4873 64166759
Acute vestibular syndrome 11.73 11.13 5 327095 31 64171601
Rhinitis 11.71 11.13 23 327077 10742 64160890
Multiple system atrophy 11.69 11.13 12 327088 375 64171257
Herpes simplex viraemia 11.68 11.13 10 327090 247 64171385
Oral surgery 11.67 11.13 19 327081 946 64170686
Aplasia pure red cell 11.66 11.13 11 327089 7003 64164629
Retinal depigmentation 11.62 11.13 11 327089 311 64171321
Hyperlactacidaemia 11.61 11.13 5 327095 4839 64166793
Treatment noncompliance 11.60 11.13 153 326947 43329 64128303
Hip fracture 11.60 11.13 85 327015 27014 64144618
Intervertebral disc space narrowing 11.55 11.13 23 327077 1341 64170291
Hepatitis cholestatic 11.55 11.13 28 327072 12127 64159505
Blood bicarbonate decreased 11.55 11.13 5 327095 4824 64166808
Venoocclusive disease 11.49 11.13 3 327097 3982 64167650
Contraindication to medical treatment 11.48 11.13 19 327081 959 64170673
Back injury 11.47 11.13 73 327027 7684 64163948
Hyperphosphataemia 11.47 11.13 3 327097 3978 64167654
Loss of employment 11.44 11.13 28 327072 1879 64169753
Palindromic rheumatism 11.39 11.13 11 327089 319 64171313
Blood calcium increased 11.39 11.13 16 327084 8526 64163106
Pseudomonal sepsis 11.38 11.13 6 327094 5166 64166466
Hepatic cytolysis 11.37 11.13 35 327065 14014 64157618
Wound dehiscence 11.27 11.13 8 327092 5866 64165766
Disseminated strongyloidiasis 11.27 11.13 7 327093 103 64171529
Culture tissue specimen positive 11.21 11.13 4 327096 14 64171618
Oesophageal carcinoma 11.20 11.13 5 327095 4738 64166894
Cryptococcal meningoencephalitis 11.20 11.13 9 327091 203 64171429
Cardiovascular disorder 11.20 11.13 42 327058 15839 64155793
Pneumonia cytomegaloviral 11.19 11.13 4 327096 4335 64167297
Mean cell haemoglobin decreased 11.19 11.13 46 327054 4076 64167556

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC P01BA02 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
ANTIMALARIALS
Aminoquinolines
FDA EPC N0000175482 Antimalarial
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000962 Antimalarials
MeSH PA D000977 Antiparasitic Agents
MeSH PA D000981 Antiprotozoal Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D004791 Enzyme Inhibitors
CHEBI has role CHEBI:35842 anti-rheumatic drugs
CHEBI has role CHEBI:38068 antimalarials
CHEBI has role CHEBI:50177 dermatologic agent
CHEBI has role CHEBI:149553 anticoronaviral drug
FDA EPC N0000175713 Antirheumatic Agent

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Ovale malaria indication 19341001 DOID:12919
Vivax malaria indication 27052006 DOID:12978
Quartan malaria indication 27618009 DOID:14324
Systemic lupus erythematosus indication 55464009 DOID:9074
Falciparum malaria indication 62676009 DOID:14067
Rheumatoid arthritis indication 69896004 DOID:7148
Discoid lupus erythematosus indication 200938002
Plasmodium Malariae Malaria Prevention indication
Plasmodium Ovale Malaria Prevention indication
Malaria Prevention indication
Plasmodium Falciparum Malaria Prevention indication
Vasculitis of the skin off-label use 53312001
Porphyria cutanea tarda off-label use 61860000 DOID:3132
Q fever endocarditis off-label use 95890006
Coronavirus infection off-label use 186747009
Polymorphic light eruption off-label use 238525001
Juvenile rheumatoid arthritis off-label use 410795001
Hypercalcemia associated with Sarcoidosis off-label use
Alcoholism contraindication 7200002
Psoriasis contraindication 9014002 DOID:8893
Visual field defect contraindication 12184005
Retinal disorder contraindication 29555009 DOID:5679
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Neutropenic disorder contraindication 303011007 DOID:1227
Disorder of macula of retina contraindication 312999006
Disorder of eye contraindication 371405004 DOID:5614
Visual impairment contraindication 397540003
Porphyria contraindication 418470004




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.51 Basic
pKa2 7.83 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Toll-like receptor 7 Membrane receptor ANTAGONIST IC50 5.56 IUPHAR CHEMBL
Toll-like receptor 9 Membrane receptor ANTAGONIST IC50 7.10 IUPHAR CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 4.14 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Ki 4.81 CHEMBL
Muscarinic acetylcholine receptor M2 GPCR Ki 5.98 DRUG MATRIX
Muscarinic acetylcholine receptor M3 GPCR Ki 5.32 CHEMBL
Muscarinic acetylcholine receptor M4 GPCR Ki 5.26 CHEMBL
Muscarinic acetylcholine receptor M5 GPCR Ki 4.70 CHEMBL
Alpha-2C adrenergic receptor GPCR Ki 4.80 CHEMBL
Hemoglobin subunit alpha Secreted WOMBAT-PK
Alpha-1D adrenergic receptor GPCR Ki 5.63 DRUG MATRIX
Transmembrane protein 97 Enzyme Ki 6 CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 5.19 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.90 CHEMBL
Genome polyprotein Unclassified Ki 4.04 CHEMBL

External reference:

IDSource
4019780 VUID
N0000147871 NUI
D02114 KEGG_DRUG
747-36-4 SECONDARY_CAS_RN
4018253 VANDF
4019780 VANDF
C0020336 UMLSCUI
CHEBI:5801 CHEBI
CHEMBL1535 ChEMBL_ID
DB01611 DRUGBANK_ID
CHEMBL1690 ChEMBL_ID
D006886 MESH_DESCRIPTOR_UI
3652 PUBCHEM_CID
7198 IUPHAR_LIGAND_ID
796 INN_ID
4QWG6N8QKH UNII
153972 RXNORM
15082 MMSL
1645 MMSL
4852 MMSL
d00817 MMSL
002949 NDDF
004906 NDDF
13502005 SNOMEDCT_US
373540008 SNOMEDCT_US
83490000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0093-2401 TABLET, FILM COATED 200 mg ORAL ANDA 25 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0373 TABLET, FILM COATED 200 mg ORAL ANDA 27 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0373 TABLET, FILM COATED 200 mg ORAL ANDA 27 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0591-3041 TABLET, FILM COATED 200 mg ORAL ANDA 25 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8374 TABLET, FILM COATED 200 mg ORAL ANDA 10 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8401 TABLET 200 mg ORAL ANDA 30 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8401 TABLET 200 mg ORAL ANDA 30 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0781-5994 TABLET, FILM COATED 200 mg ORAL ANDA 25 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0781-5994 TABLET, FILM COATED 200 mg ORAL ANDA 25 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6884 TABLET, FILM COATED 200 mg ORAL ANDA 14 sections
HYDROXYCHLOROQUINE SULFATE HUMAN PRESCRIPTION DRUG LABEL 1 0904-7046 TABLET 200 mg ORAL ANDA 17 sections
HYDROXYCHLOROQUINE SULFATE HUMAN PRESCRIPTION DRUG LABEL 1 0904-7046 TABLET 200 mg ORAL ANDA 17 sections
Hydroxychloroquine Sulfate Human Prescription Drug Label 1 16571-687 TABLET, FILM COATED 200 mg ORAL ANDA 11 sections
Hydroxychloroquine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16714-110 TABLET, FILM COATED 200 mg ORAL ANDA 25 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16714-753 TABLET, FILM COATED 200 mg ORAL ANDA 25 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16714-753 TABLET, FILM COATED 200 mg ORAL ANDA 25 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16729-485 TABLET 200 mg ORAL ANDA 26 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16729-561 TABLET 100 mg ORAL ANDA 26 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16729-562 TABLET 300 mg ORAL ANDA 26 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16729-563 TABLET 400 mg ORAL ANDA 26 sections
Hydroxychloroquine Sulfate Human Prescription Drug Label 1 42385-927 TABLET, FILM COATED 200 mg ORAL ANDA 11 sections
Hydroxychloroquine Sulfate Human Prescription Drug Label 1 43353-051 TABLET 200 mg ORAL NDA AUTHORIZED GENERIC 24 sections
HYDROXYCHLOROQUINE SULFATE Human Prescription Drug Label 1 43598-721 TABLET 200 mg ORAL ANDA 17 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 50090-2508 TABLET, FILM COATED 200 mg ORAL ANDA 16 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 50090-2508 TABLET, FILM COATED 200 mg ORAL ANDA 16 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 50090-3432 TABLET 200 mg ORAL NDA AUTHORIZED GENERIC 24 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 50090-4659 TABLET, FILM COATED 200 mg ORAL ANDA 20 sections
HYDROXYCHLOROQUINE SULFATE HUMAN PRESCRIPTION DRUG LABEL 1 50090-5388 TABLET 200 mg ORAL ANDA 9 sections
Hydroxychloroquine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 50090-5573 TABLET, FILM COATED 200 mg ORAL ANDA 12 sections
Hydroxychloroquine Sulfate Human Prescription Drug Label 1 50090-5675 TABLET, FILM COATED 200 mg ORAL ANDA 11 sections