hydroxychloroquine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
quinoline derivatives 1395 118-42-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hydroxychloroquine
  • hydroxychloroquine sulfate
  • oxichloroquine
  • oxychlorochin
  • oxychloroquine
A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970). In March 2020, FDA issued an emergency use authorization (EUA) for hydroxychloroquine and chloroquine in the treatment of COVID-10. EUA was revoked in June 2020. Data from various published randomized, controlled clinical trials and retrospective, cohort studies have not substantiated initial reports of efficacy of 4-aminoquinoline antimalarials for treatment of COVID-19.
  • Molecular weight: 335.88
  • Formula: C18H26ClN3O
  • CLOGP: 4.12
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 48.39
  • ALOGS: -4.11
  • ROTB: 9

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.52 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 200 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 27 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 29.77 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 74 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 700 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 11 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.57 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 850 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
April 18, 1955 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 7892.46 10.68 8285 265418 231930 46180429
Drug ineffective 7657.11 10.68 13895 259808 663943 45748416
Drug intolerance 4843.18 10.68 5090 268613 141959 46270400
Contraindicated product administered 3021.73 10.68 2985 270718 76962 46335397
Synovitis 2816.99 10.68 2547 271156 58528 46353831
Treatment failure 2776.36 10.68 3062 270641 90025 46322334
Joint swelling 2745.77 10.68 4072 269631 162001 46250358
Therapeutic product effect decreased 1656.17 10.68 2224 271479 80377 46331982
Systemic lupus erythematosus 1496.80 10.68 1877 271826 63303 46349056
Arthropathy 1326.45 10.68 2028 271675 82672 46329687
C-reactive protein abnormal 1040.45 10.68 918 272785 20352 46392007
Therapeutic product effect incomplete 1030.98 10.68 1731 271972 76422 46335937
Pemphigus 1004.27 10.68 1282 272421 43992 46368367
Arthralgia 998.51 10.68 4501 269202 360102 46052257
Death 983.66 10.68 370 273333 335178 46077181
Abdominal discomfort 967.06 10.68 2484 271219 148681 46263678
Pain 821.07 10.68 5181 268522 471767 45940592
Hand deformity 801.51 10.68 1001 272702 33573 46378786
Red blood cell sedimentation rate abnormal 800.57 10.68 654 273049 12995 46399364
Rheumatoid factor positive 799.18 10.68 779 272924 19682 46392677
Alopecia 733.36 10.68 2355 271348 160059 46252300
Musculoskeletal stiffness 713.52 10.68 1693 272010 96300 46316059
Glossodynia 647.22 10.68 1029 272674 43344 46369015
Loss of personal independence in daily activities 620.16 10.68 1163 272540 56020 46356339
Drug hypersensitivity 618.10 10.68 2946 270757 240879 46171480
Off label use 613.89 10.68 4064 269639 375777 46036582
Condition aggravated 595.35 10.68 2925 270778 242127 46170232
Swelling 587.79 10.68 1834 271869 122677 46289682
Red blood cell sedimentation rate increased 559.89 10.68 681 273022 22208 46390151
Acute kidney injury 559.36 10.68 346 273357 235509 46176850
Completed suicide 550.55 10.68 96 273607 145824 46266535
Hepatic enzyme increased 539.79 10.68 1361 272342 80426 46331933
Anti-cyclic citrullinated peptide antibody positive 490.17 10.68 583 273120 18562 46393797
Peripheral swelling 476.66 10.68 2012 271691 156059 46256300
C-reactive protein increased 463.19 10.68 1046 272657 57544 46354815
Dyspnoea 429.33 10.68 1568 272135 513980 45898379
Retinal toxicity 396.79 10.68 170 273533 903 46411456
Dehydration 383.59 10.68 230 273473 159310 46253049
Anaemia 380.75 10.68 569 273134 255210 46157149
Constipation 364.21 10.68 292 273411 173805 46238554
Confusional state 342.24 10.68 262 273441 159630 46252729
Hyponatraemia 338.49 10.68 88 273615 101244 46311115
Blood iron abnormal 332.49 10.68 216 273487 2954 46409405
Hypotension 326.49 10.68 538 273165 232051 46180308
Malignant neoplasm progression 307.95 10.68 18 273685 64908 46347451
Febrile neutropenia 305.14 10.68 88 273615 94539 46317820
Mobility decreased 291.49 10.68 899 272804 59695 46352664
Seizure 290.68 10.68 181 273522 122873 46289486
Tremor 290.32 10.68 158 273545 115481 46296878
Rheumatoid nodule 289.48 10.68 309 273394 8711 46403648
Knee arthroplasty 289.02 10.68 507 273196 23158 46389201
Impaired work ability 278.64 10.68 357 273346 12279 46400080
Rash 274.16 10.68 3243 270460 353269 46059090
Arthritis 270.97 10.68 1032 272671 76284 46336075
Retinopathy 264.12 10.68 170 273533 2286 46410073
Inflammation 261.41 10.68 752 272951 48029 46364330
Infection 255.64 10.68 1495 272208 132097 46280262
Drug abuse 251.90 10.68 36 273667 63372 46348987
Drug interaction 249.96 10.68 509 273194 202585 46209774
Wound 237.29 10.68 668 273035 42134 46370225
Musculoskeletal disorder 236.91 10.68 368 273335 15177 46397182
Anxiety 234.27 10.68 444 273259 181513 46230846
Product use issue 234.20 10.68 1137 272566 93507 46318852
Bone erosion 230.93 10.68 281 273422 9162 46403197
Bradycardia 230.29 10.68 53 273650 66245 46346114
Overdose 225.99 10.68 161 273542 101818 46310541
Osteoarthritis 224.84 10.68 837 272866 61188 46351171
Pulmonary embolism 222.11 10.68 186 273517 108399 46303960
Somnolence 219.48 10.68 362 273341 156159 46256200
Psoriatic arthropathy 218.81 10.68 585 273118 35794 46376565
Atrial fibrillation 213.66 10.68 176 273527 103414 46308945
Pericarditis 210.34 10.68 446 273257 23481 46388878
Toxicity to various agents 208.90 10.68 596 273107 211170 46201189
Disability 200.60 10.68 272 273431 9895 46402464
Renal failure 200.44 10.68 222 273481 113372 46298987
Fibromyalgia 199.11 10.68 566 273137 35897 46376462
Joint range of motion decreased 199.08 10.68 335 273368 14789 46397570
Cardio-respiratory arrest 197.96 10.68 53 273650 59816 46352543
Musculoskeletal pain 197.42 10.68 875 272828 69253 46343106
Dizziness 188.52 10.68 1196 272507 339218 46073141
Hip arthroplasty 188.29 10.68 362 273341 17750 46394609
Hyperkalaemia 187.54 10.68 35 273668 50674 46361685
Multiple sclerosis relapse 187.27 10.68 16 273687 42109 46370250
Gastrointestinal haemorrhage 185.16 10.68 112 273591 77261 46335098
Pulmonary fibrosis 184.17 10.68 381 273322 19711 46392648
Gastrointestinal disorder 181.24 10.68 761 272942 58815 46353544
Coma 179.53 10.68 59 273644 58290 46354069
Pyrexia 178.34 10.68 1255 272448 347547 46064812
Tachycardia 174.32 10.68 196 273507 99426 46312933
Neutropenia 174.29 10.68 361 273342 142843 46269516
Plasma cell myeloma 172.63 10.68 27 273676 44451 46367908
Product dose omission issue 170.04 10.68 469 273234 168051 46244308
Thrombocytopenia 169.84 10.68 301 273402 126280 46286079
Decreased appetite 166.86 10.68 580 273123 193256 46219103
Tenosynovitis 166.75 10.68 213 273490 7302 46405057
Grip strength decreased 166.40 10.68 228 273475 8378 46403981
Depressed level of consciousness 165.24 10.68 38 273665 47531 46364828
Hypersensitivity 162.49 10.68 1467 272236 148854 46263505
Infusion related reaction 162.44 10.68 1083 272620 100125 46312234
Liver function test increased 162.18 10.68 391 273312 22435 46389924
Therapeutic response decreased 162.01 10.68 589 273114 42556 46369803
Shoulder arthroplasty 161.68 10.68 139 273564 2969 46409390
Agitation 158.66 10.68 63 273640 55352 46357007
Deformity 156.81 10.68 203 273500 7054 46405305
Hallucination 156.35 10.68 49 273654 49902 46362457
Neutrophil count decreased 156.32 10.68 32 273671 43394 46368965
Cardiac arrest 153.67 10.68 182 273521 90217 46322142
Cerebrovascular accident 152.73 10.68 222 273481 100817 46311542
Oedema peripheral 150.50 10.68 459 273244 159247 46253112
Finger deformity 150.26 10.68 168 273535 4994 46407365
Blood parathyroid hormone decreased 149.34 10.68 155 273548 4226 46408133
Granuloma skin 148.49 10.68 139 273564 3331 46409028
Panniculitis 148.11 10.68 175 273528 5529 46406830
Asthenia 147.54 10.68 1143 272560 309932 46102427
Suicide attempt 147.34 10.68 69 273634 54967 46357392
Platelet count decreased 146.11 10.68 225 273478 99799 46312560
Abdominal pain 145.99 10.68 773 272930 229258 46183101
Intentional overdose 144.54 10.68 102 273601 64842 46347517
Deafness transitory 144.26 10.68 100 273603 1532 46410827
White blood cell count decreased 144.21 10.68 274 273429 111957 46300402
Haemoglobin decreased 143.81 10.68 341 273362 128608 46283751
Maternal exposure during pregnancy 143.27 10.68 1061 272642 101488 46310871
Lactic acidosis 142.54 10.68 16 273687 33893 46378466
Joint stiffness 142.38 10.68 415 273288 26693 46385666
Fine motor skill dysfunction 139.06 10.68 138 273565 3562 46408797
Rhabdomyolysis 136.85 10.68 38 273665 41871 46370488
Muscle spasms 134.57 10.68 329 273374 122784 46289575
X-ray abnormal 134.17 10.68 85 273618 1110 46411249
Maculopathy 133.76 10.68 95 273608 1516 46410843
Disease progression 133.71 10.68 205 273498 91095 46321264
Blood glucose increased 133.41 10.68 135 273568 71878 46340481
Metabolic acidosis 132.68 10.68 32 273671 38748 46373611
Cardiac failure congestive 132.47 10.68 208 273495 91542 46320817
Joint effusion 132.43 10.68 246 273457 11749 46400610
Fall 129.93 10.68 1268 272435 327829 46084530
Herpes zoster 129.29 10.68 759 272944 67113 46345246
Eye disorder 129.14 10.68 311 273392 17830 46394529
Neoplasm progression 127.73 10.68 7 273696 26676 46385683
Balance disorder 126.46 10.68 115 273588 64406 46347953
Lupus nephritis 124.11 10.68 104 273599 2142 46410217
Deep vein thrombosis 122.79 10.68 173 273530 79600 46332759
Discomfort 122.11 10.68 570 273133 46100 46366259
Joint destruction 122.10 10.68 118 273585 2946 46409413
Musculoskeletal deformity 121.30 10.68 69 273634 730 46411629
Cardiac failure 119.49 10.68 177 273526 79771 46332588
Syncope 119.36 10.68 274 273429 104529 46307830
Breast cancer stage III 118.94 10.68 83 273620 1286 46411073
International normalised ratio increased 116.22 10.68 65 273638 46818 46365541
Device expulsion 115.76 10.68 13 273690 27529 46384830
Epistaxis 115.23 10.68 124 273579 64181 46348178
Polyarthritis 112.68 10.68 164 273539 6378 46405981
Respiratory arrest 111.65 10.68 30 273673 33786 46378573
Spinal stenosis 111.61 10.68 235 273468 12308 46400051
Product quality issue 111.50 10.68 35 273668 35613 46376746
Tuberculin test positive 110.98 10.68 111 273592 2893 46409466
Drug withdrawal syndrome 110.02 10.68 15 273688 27369 46384990
Nodule 109.45 10.68 266 273437 15339 46397020
Ill-defined disorder 109.08 10.68 376 273327 26451 46385908
Blood pressure decreased 108.35 10.68 105 273598 57054 46355305
Elbow deformity 107.77 10.68 78 273625 1284 46411075
Sepsis 107.76 10.68 421 273282 135593 46276766
Disturbance in attention 106.11 10.68 27 273676 31533 46380826
Pulmonary toxicity 105.68 10.68 134 273569 4559 46407800
Urinary tract infection 104.92 10.68 808 272895 219458 46192901
Hypoxia 104.47 10.68 90 273613 51748 46360611
Respiratory failure 103.89 10.68 253 273450 94563 46317796
Drug tolerance decreased 103.86 10.68 108 273595 2951 46409408
Cognitive disorder 103.84 10.68 43 273660 36840 46375519
Arthrodesis 103.30 10.68 94 273609 2170 46410189
SLE arthritis 102.93 10.68 57 273646 570 46411789
Serotonin syndrome 102.89 10.68 11 273692 24209 46388150
Dysphagia 102.61 10.68 185 273518 77127 46335232
Pneumonia viral 102.58 10.68 158 273545 6466 46405893
Adverse reaction 102.24 10.68 176 273527 7914 46404445
Hyperhidrosis 102.09 10.68 233 273470 89075 46323284
Chest pain 101.77 10.68 611 273092 175713 46236646
Glaucoma 100.77 10.68 261 273442 15660 46396699
Joint laxity 99.52 10.68 89 273614 2007 46410352
Bone density decreased 99.01 10.68 193 273510 9559 46402800
Helicobacter infection 98.81 10.68 215 273488 11521 46400838
Sopor 98.79 10.68 4 273699 19824 46392535
Sciatica 97.79 10.68 289 273414 18731 46393628
Body height below normal 97.20 10.68 83 273620 1756 46410603
Adverse drug reaction 97.04 10.68 515 273188 43847 46368512
Dyskinesia 96.75 10.68 25 273678 28900 46383459
Disorientation 96.20 10.68 48 273655 36870 46375489
Osteoporosis 96.17 10.68 482 273221 40126 46372233
Depression 95.79 10.68 594 273109 169510 46242849
Seronegative arthritis 95.73 10.68 58 273645 696 46411663
Wrong technique in product usage process 94.15 10.68 108 273595 54314 46358045
Mouth ulceration 93.78 10.68 358 273345 26474 46385885
Feeling abnormal 93.46 10.68 396 273307 124664 46287695
Palmar-plantar erythrodysaesthesia syndrome 93.04 10.68 7 273696 20444 46391915
Interstitial lung disease 93.03 10.68 588 273115 53361 46358998
Human antichimeric antibody positive 92.75 10.68 72 273631 1324 46411035
Hepatic failure 92.40 10.68 40 273663 33376 46378983
Hepatic function abnormal 92.36 10.68 43 273660 34378 46377981
Oral mucosal exfoliation 92.27 10.68 75 273628 1478 46410881
Hypoglycaemia 91.72 10.68 110 273593 54239 46358120
Paraesthesia 91.42 10.68 366 273337 117071 46295288
Unresponsive to stimuli 91.40 10.68 37 273666 32137 46380222
Hyperglycaemia 90.78 10.68 46 273657 35025 46377334
Diarrhoea 90.21 10.68 2546 271157 557056 45855303
Blood bilirubin increased 89.74 10.68 44 273659 34140 46378219
Irritability 89.50 10.68 29 273674 28917 46383442
Surgical failure 89.43 10.68 61 273642 909 46411450
Suicidal ideation 88.03 10.68 121 273582 56261 46356098
Melaena 87.34 10.68 27 273676 27745 46384614
Duodenal ulcer perforation 87.22 10.68 169 273534 8333 46404026
Pneumonia aspiration 87.12 10.68 38 273665 31567 46380792
Foot deformity 86.69 10.68 242 273461 15183 46397176
Fluid retention 86.48 10.68 103 273600 50943 46361416
Multiple organ dysfunction syndrome 85.84 10.68 106 273597 51604 46360755
Bone pain 85.59 10.68 89 273614 46801 46365558
Asthma 85.52 10.68 264 273439 91278 46321081
Cerebral haemorrhage 84.98 10.68 30 273673 28341 46384018
Sedation 84.30 10.68 16 273687 22894 46389465
Rheumatoid factor negative 84.28 10.68 48 273655 509 46411850
Spinal column injury 84.14 10.68 76 273627 1737 46410622
Encephalopathy 84.07 10.68 46 273657 33543 46378816
Vomiting 84.03 10.68 2018 271685 450776 45961583
Restlessness 83.59 10.68 23 273680 25501 46386858
Abnormal behaviour 83.51 10.68 12 273691 21046 46391313
Myalgia 82.87 10.68 405 273298 122683 46289676
Myocardial infarction 82.36 10.68 294 273409 97234 46315125
Colitis microscopic 82.03 10.68 142 273561 6414 46405945
Pleural effusion 81.25 10.68 234 273469 82718 46329641
Physical disability 80.54 10.68 75 273628 1785 46410574
Cholelithiasis 79.36 10.68 66 273637 38615 46373744
Sinusitis 78.89 10.68 1132 272571 128636 46283723
Emotional distress 78.40 10.68 41 273662 30666 46381693
Investigation abnormal 78.26 10.68 58 273645 992 46411367
Hypokalaemia 77.94 10.68 260 273443 87764 46324595
Pulmonary oedema 77.47 10.68 112 273591 50993 46361366
Lethargy 75.76 10.68 114 273589 51057 46361302
Intentional self-injury 75.09 10.68 24 273679 24142 46388217
Gastrointestinal pain 75.03 10.68 147 273556 7308 46405051
Neuropathy peripheral 74.76 10.68 277 273426 90616 46321743
Intentional product use issue 74.74 10.68 548 273155 52232 46360127
Dysarthria 74.47 10.68 66 273637 37432 46374927
Metastases to bone 74.07 10.68 8 273695 17468 46394891
Lower respiratory tract infection 74.07 10.68 565 273138 54524 46357835
Accidental overdose 73.86 10.68 14 273689 20052 46392307
Ulcer 73.54 10.68 247 273456 17145 46395214
Mental status changes 73.31 10.68 69 273634 38019 46374340
Juvenile idiopathic arthritis 73.23 10.68 105 273598 4027 46408332
Neck pain 73.12 10.68 565 273138 54741 46357618
Skin necrosis 71.72 10.68 157 273546 8447 46403912
Aggression 71.72 10.68 22 273681 22722 46389637
Rectal haemorrhage 71.65 10.68 71 273632 38184 46374175
Jaundice 71.47 10.68 40 273663 28805 46383554
Wheelchair user 71.25 10.68 102 273601 3906 46408453
Chest discomfort 70.44 10.68 281 273422 89988 46322371
Haemorrhage 70.40 10.68 134 273569 54735 46357624
Osteonecrosis of jaw 70.20 10.68 59 273644 34343 46378016
Onychomycosis 70.11 10.68 103 273600 4040 46408319
Pancytopenia 69.44 10.68 260 273443 84798 46327561
Epicondylitis 69.25 10.68 67 273636 1675 46410684
Loose body in joint 69.15 10.68 54 273649 1002 46411357
Fear of injection 68.59 10.68 102 273601 4045 46408314
Generalised tonic-clonic seizure 68.09 10.68 37 273666 27085 46385274
Blood alkaline phosphatase increased 68.08 10.68 79 273624 39530 46372829
Injection site reaction 67.86 10.68 497 273206 47352 46365007
Viral upper respiratory tract infection 67.76 10.68 136 273567 6882 46405477
Dysgeusia 67.21 10.68 83 273620 40408 46371951
Epilepsy 66.29 10.68 28 273675 23710 46388649
Vertigo 65.13 10.68 129 273574 51919 46360440
Rheumatoid lung 64.99 10.68 64 273639 1636 46410723
Respiratory distress 64.80 10.68 55 273648 31861 46380498
Red blood cell sedimentation rate 64.55 10.68 65 273638 1708 46410651
Vision blurred 63.55 10.68 246 273457 79462 46332897
Urinary retention 63.34 10.68 37 273666 26024 46386335
Blood urea increased 63.04 10.68 35 273668 25317 46387042
Drug eruption 62.92 10.68 270 273433 21059 46391300
Ascites 62.84 10.68 73 273630 36511 46375848
Hospitalisation 62.66 10.68 178 273525 63207 46349152
Hypomagnesaemia 62.34 10.68 26 273677 22184 46390175
Speech disorder 62.30 10.68 72 273631 36095 46376264
Device dislocation 62.04 10.68 25 273678 21777 46390582
Wheezing 62.03 10.68 138 273565 53248 46359111
Altered state of consciousness 61.36 10.68 30 273673 23318 46389041
Circulatory collapse 61.20 10.68 25 273678 21599 46390760
Dislocation of vertebra 60.86 10.68 55 273648 1258 46411101
Back injury 60.80 10.68 129 273574 6792 46405567
Full blood count decreased 60.75 10.68 27 273676 22184 46390175
Transient ischaemic attack 60.65 10.68 69 273634 34834 46377525
Colitis 60.48 10.68 78 273625 37269 46375090
Acute myocardial infarction 60.08 10.68 59 273644 31865 46380494
Gastrooesophageal reflux disease 59.55 10.68 229 273474 74115 46338244
Red cell distribution width decreased 59.39 10.68 46 273657 843 46411516
Gamma-glutamyltransferase increased 59.34 10.68 59 273644 31681 46380678
Joint injury 58.86 10.68 246 273457 18963 46393396
Pneumonia 58.45 10.68 1720 271983 374600 46037759
Metastases to liver 58.16 10.68 21 273682 19564 46392795
Vascular access complication 58.13 10.68 47 273656 919 46411440
Haematoma 57.60 10.68 61 273642 31811 46380548
Pancreatitis 57.33 10.68 105 273598 43522 46368837
Coronary artery disease 57.27 10.68 68 273635 33684 46378675
Bone density abnormal 57.06 10.68 80 273623 3004 46409355
Aphasia 57.06 10.68 50 273653 28517 46383842
Pain in extremity 56.86 10.68 1949 271754 256731 46155628
Diabetic ketoacidosis 56.73 10.68 18 273685 18192 46394167
Flushing 56.40 10.68 192 273511 64422 46347937
Swollen tongue 56.20 10.68 53 273650 29179 46383180
Blood calcium decreased 55.47 10.68 12 273691 15661 46396698
Enthesopathy 55.33 10.68 99 273604 4591 46407768
Hypoaesthesia 55.14 10.68 439 273264 118430 46293929
Acute respiratory failure 54.66 10.68 54 273649 29084 46383275
Cerebral infarction 54.25 10.68 35 273668 23331 46389028
Chills 54.18 10.68 335 273368 95697 46316662
Small intestinal obstruction 54.04 10.68 14 273689 16158 46396201
Infusion site reaction 53.95 10.68 59 273644 1710 46410649
Palpitations 53.90 10.68 332 273371 94927 46317432
Adverse event 53.69 10.68 364 273339 33820 46378539
Chronic obstructive pulmonary disease 53.25 10.68 167 273536 57466 46354893
Upper gastrointestinal haemorrhage 53.12 10.68 16 273687 16722 46395637
Status epilepticus 53.08 10.68 9 273694 13970 46398389
Memory impairment 52.29 10.68 254 273449 77083 46335276
Cutaneous vasculitis 51.98 10.68 88 273615 3903 46408456
Erythema 51.78 10.68 561 273142 142259 46270100
Blood potassium decreased 51.46 10.68 90 273613 37973 46374386
Bone marrow failure 51.17 10.68 59 273644 29610 46382749
Drug specific antibody 51.10 10.68 49 273654 1211 46411148
Foot operation 50.85 10.68 96 273607 4641 46407718
Pleural thickening 50.54 10.68 69 273634 2526 46409833
Complication associated with device 50.40 10.68 14 273689 15427 46396932
Delirium 50.35 10.68 88 273615 37140 46375219
Therapy non-responder 50.33 10.68 413 273290 40739 46371620
Myopathy toxic 50.25 10.68 27 273676 253 46412106
Arrhythmia 50.24 10.68 79 273624 34762 46377597
Neck mass 50.22 10.68 78 273625 3215 46409144
Acute myeloid leukaemia 50.22 10.68 15 273688 15763 46396596
Ovarian neoplasm 49.90 10.68 40 273663 772 46411587
Intentional product misuse 49.85 10.68 128 273575 47000 46365359
Withdrawal syndrome 49.67 10.68 22 273681 18112 46394247
Lymphocyte count decreased 49.66 10.68 46 273657 25543 46386816
Inappropriate antidiuretic hormone secretion 49.50 10.68 11 273692 14091 46398268
Product prescribing error 49.38 10.68 28 273675 20019 46392340
Flatulence 49.19 10.68 58 273645 28820 46383539
Presbyacusis 48.97 10.68 71 273632 2751 46409608
Abdominal distension 48.97 10.68 242 273461 73109 46339250
Neutropenic sepsis 48.92 10.68 7 273696 12317 46400042
Sensitivity to weather change 48.67 10.68 103 273600 5413 46406946
Wrist deformity 48.53 10.68 52 273651 1472 46410887
Diverticulitis 48.47 10.68 346 273357 32693 46379666
Hallucination, visual 48.46 10.68 22 273681 17851 46394508
Infective pulmonary exacerbation of cystic fibrosis 48.31 10.68 4 273699 10803 46401556
Fluid overload 48.05 10.68 53 273650 27132 46385227
Nasopharyngitis 47.93 10.68 1212 272491 152786 46259573
Soft tissue disorder 47.65 10.68 87 273616 4099 46408260
Mean platelet volume decreased 47.63 10.68 52 273651 1504 46410855
Antibody test positive 47.46 10.68 61 273642 2104 46410255
Tubulointerstitial nephritis 47.18 10.68 14 273689 14774 46397585
Psychotic disorder 47.14 10.68 38 273665 22583 46389776
Synovial cyst 47.08 10.68 121 273582 7225 46405134
Blood count abnormal 46.94 10.68 23 273680 17855 46394504
Drug level increased 46.52 10.68 25 273678 18416 46393943
Chronic kidney disease 46.38 10.68 107 273596 40764 46371595
Ear infection 46.17 10.68 261 273442 22752 46389607
Disseminated intravascular coagulation 46.16 10.68 27 273676 18978 46393381
Pharyngitis 46.15 10.68 215 273488 17368 46394991
Ocular toxicity 46.14 10.68 31 273672 450 46411909
Renal impairment 45.92 10.68 252 273451 74120 46338239
Extremity contracture 45.90 10.68 45 273658 1144 46411215
Cardiac disorder 45.71 10.68 120 273583 43738 46368621
Osteoporotic fracture 45.58 10.68 71 273632 2934 46409425
Renal tubular necrosis 45.41 10.68 5 273698 10754 46401605
Onychomadesis 45.33 10.68 69 273634 2794 46409565
Gastritis 44.94 10.68 83 273620 34295 46378064
Urinary incontinence 44.75 10.68 61 273642 28469 46383890
Ischaemic stroke 44.69 10.68 21 273682 16701 46395658
Multiple fractures 44.62 10.68 100 273603 5467 46406892
Pallor 44.54 10.68 42 273661 23124 46389235
Deafness neurosensory 44.48 10.68 88 273615 4406 46407953
Pleural fibrosis 44.25 10.68 77 273626 3492 46408867
Multiple sclerosis 44.18 10.68 48 273655 24743 46387616
Dysuria 44.18 10.68 59 273644 27774 46384585
Sleep disorder due to general medical condition, insomnia type 44.00 10.68 96 273607 5153 46407206
Mental disorder 43.89 10.68 40 273663 22385 46389974
Blood triglycerides increased 43.84 10.68 8 273695 11775 46400584
Oedema 43.79 10.68 223 273480 66848 46345511
Anti-cyclic citrullinated peptide antibody 43.75 10.68 25 273678 267 46412092
Ankle arthroplasty 43.67 10.68 33 273670 582 46411777
Product administration error 43.65 10.68 31 273672 19650 46392709
Hepatocellular injury 43.47 10.68 66 273637 29456 46382903
Mucosal inflammation 43.46 10.68 103 273600 38873 46373486
Acute hepatic failure 43.35 10.68 16 273687 14705 46397654
Myoclonus 43.28 10.68 15 273688 14337 46398022
Pulmonary arterial hypertension 43.18 10.68 53 273650 25875 46386484
Diabetes mellitus inadequate control 43.10 10.68 12 273691 13202 46399157
Cutaneous lupus erythematosus 42.97 10.68 63 273640 2466 46409893
Blood cholesterol increased 42.88 10.68 390 273313 39623 46372736
Phospholipidosis 42.80 10.68 16 273687 55 46412304
Transaminases abnormal 42.54 10.68 31 273672 516 46411843
Impaired healing 42.41 10.68 364 273339 36379 46375980
Product label confusion 42.21 10.68 26 273677 322 46412037
Paranoia 42.11 10.68 6 273697 10591 46401768
Laryngeal disorder 42.05 10.68 37 273666 816 46411543
Coeliac disease 41.87 10.68 114 273589 7047 46405312
Lupus vasculitis 41.85 10.68 29 273674 444 46411915
Neck deformity 41.84 10.68 53 273650 1801 46410558
Device related infection 41.82 10.68 37 273666 21004 46391355
Mean cell volume decreased 41.78 10.68 61 273642 2379 46409980
Bronchitis chronic 41.73 10.68 82 273621 4085 46408274
Coordination abnormal 41.68 10.68 7 273696 10942 46401417
Muscle twitching 41.46 10.68 17 273686 14655 46397704
Alanine aminotransferase increased 41.31 10.68 326 273377 88125 46324234
Accident 41.26 10.68 92 273611 5012 46407347
Cyanosis 41.25 10.68 21 273682 15950 46396409
Electrolyte imbalance 41.10 10.68 25 273678 17201 46395158
Dementia 41.07 10.68 18 273685 14912 46397447
Metastases to central nervous system 40.94 10.68 8 273695 11213 46401146
Sleep disorder 40.84 10.68 437 273266 46358 46366001
Blood lactate dehydrogenase increased 40.80 10.68 36 273667 20464 46391895
Haemorrhage intracranial 40.68 10.68 12 273691 12712 46399647
Neuroleptic malignant syndrome 40.43 10.68 8 273695 11114 46401245
Blood glucose decreased 40.30 10.68 31 273672 18861 46393498
Inappropriate schedule of product administration 40.29 10.68 220 273483 64793 46347566
Basal cell carcinoma 40.21 10.68 231 273472 20256 46392103
Incorrect dose administered 39.99 10.68 135 273568 45415 46366944
Poisoning 39.90 10.68 16 273687 13978 46398381
Oxygen saturation decreased 39.67 10.68 240 273463 68924 46343435
Muscle injury 39.66 10.68 88 273615 4778 46407581
Overlap syndrome 39.66 10.68 31 273672 576 46411783
Haematuria 39.59 10.68 60 273643 26798 46385561
Mental impairment 39.36 10.68 12 273691 12444 46399915
Blood creatinine increased 39.31 10.68 274 273429 76129 46336230
Nervous system disorder 39.05 10.68 23 273680 16106 46396253
Insomnia 39.00 10.68 706 272997 164218 46248141
Clostridium difficile colitis 38.87 10.68 31 273672 18522 46393837
Respiratory depression 38.84 10.68 10 273693 11590 46400769
Schizophrenia 38.78 10.68 3 273700 8565 46403794
Coagulopathy 38.64 10.68 31 273672 18468 46393891
Neurotoxicity 38.59 10.68 16 273687 13701 46398658
Head injury 38.31 10.68 53 273650 24583 46387776
Anger 38.22 10.68 11 273692 11841 46400518
Joint arthroplasty 38.13 10.68 53 273650 1974 46410385
Acquired pigmented retinopathy 38.11 10.68 10 273693 4 46412355
Haematochezia 38.00 10.68 104 273599 37389 46374970
International normalised ratio fluctuation 37.80 10.68 55 273648 2138 46410221
Hair follicle tumour benign 37.56 10.68 25 273678 357 46412002
Bone swelling 37.52 10.68 41 273662 1187 46411172
Subacute cutaneous lupus erythematosus 37.42 10.68 51 273652 1864 46410495
Accidental exposure to product 37.36 10.68 41 273662 21040 46391319
Hepatotoxicity 37.32 10.68 263 273440 24746 46387613
Haematemesis 37.25 10.68 70 273633 28736 46383623
Aspartate aminotransferase increased 37.25 10.68 289 273414 78411 46333948
Depressed mood 37.19 10.68 88 273615 33231 46379128
Feeling hot 37.12 10.68 107 273596 37821 46374538
Restrictive cardiomyopathy 37.06 10.68 23 273680 289 46412070
Mania 37.00 10.68 9 273694 10837 46401522
Hemiparesis 36.72 10.68 38 273665 20031 46392328
Pruritus 36.72 10.68 1111 272592 241241 46171118
Wrist surgery 36.51 10.68 33 273670 755 46411604
Hypothermia 36.28 10.68 13 273690 12170 46400189
Anuria 36.14 10.68 11 273692 11420 46400939
Pulmonary mass 36.14 10.68 203 273500 17654 46394705
Muscular weakness 36.04 10.68 354 273349 91490 46320869
Swelling face 36.02 10.68 174 273529 52885 46359474
Device difficult to use 35.68 10.68 3 273700 8001 46404358
Swollen joint count increased 35.43 10.68 56 273647 2344 46410015
Parkinsonism 35.37 10.68 3 273700 7945 46404414
Extrapyramidal disorder 35.35 10.68 11 273692 11257 46401102
Sleep apnoea syndrome 35.30 10.68 47 273656 22154 46390205
Mood altered 35.28 10.68 16 273687 12991 46399368
Glycosylated haemoglobin increased 35.24 10.68 10 273693 10866 46401493
Dry skin 35.03 10.68 123 273580 40893 46371466
Shock 34.98 10.68 46 273657 21799 46390560
Cytomegalovirus infection 34.76 10.68 33 273670 18111 46394248
Underdose 34.71 10.68 38 273665 19520 46392839
Ankle operation 34.49 10.68 39 273664 1174 46411185
Mesenteritis 34.45 10.68 17 273686 131 46412228
Bone disorder 34.30 10.68 218 273485 19815 46392544
Infiltration anaesthesia 34.23 10.68 17 273686 133 46412226
Nail disorder 34.14 10.68 113 273590 7783 46404576
Back pain 34.04 10.68 954 272749 209085 46203274
Tachypnoea 34.00 10.68 21 273682 14330 46398029
Cushingoid 33.93 10.68 97 273606 6169 46406190
Dry eye 33.75 10.68 298 273405 30024 46382335
Vasculitic rash 33.69 10.68 40 273663 1270 46411089
Tenderness 33.56 10.68 191 273512 16690 46395669
Blood magnesium increased 33.31 10.68 62 273641 2965 46409394
Tardive dyskinesia 33.15 10.68 3 273700 7540 46404819
Lung disorder 33.08 10.68 394 273309 42910 46369449
Ileus 32.74 10.68 21 273682 14043 46398316
Abortion spontaneous 32.70 10.68 138 273565 43508 46368851
Poisoning deliberate 32.66 10.68 4 273699 7922 46404437
Muscle rigidity 32.57 10.68 9 273694 9952 46402407
Cholestasis 32.49 10.68 68 273635 26825 46385534
Breast cancer metastatic 32.42 10.68 20 273683 13658 46398701
Renal injury 32.38 10.68 8 273695 9533 46402826
Hypophosphataemia 32.19 10.68 3 273700 7364 46404995
Retinal degeneration 32.13 10.68 26 273677 509 46411850
Nightmare 32.02 10.68 30 273673 16568 46395791
Nervousness 31.94 10.68 75 273628 28400 46383959
Pulmonary congestion 31.93 10.68 24 273679 14775 46397584
Anovulatory cycle 31.81 10.68 16 273687 129 46412230
Femur fracture 31.58 10.68 344 273359 36653 46375706
Blood sodium decreased 31.57 10.68 49 273654 21677 46390682
Akathisia 31.53 10.68 4 273699 7710 46404649
Mean cell haemoglobin decreased 31.24 10.68 59 273644 2853 46409506
Optical coherence tomography abnormal 31.12 10.68 9 273694 9 46412350
Rheumatic fever 31.00 10.68 58 273645 2785 46409574
Pustular psoriasis 30.91 10.68 71 273632 3946 46408413
Vaginal haemorrhage 30.72 10.68 65 273638 25539 46386820
Blood magnesium decreased 30.64 10.68 13 273690 10979 46401380
Abdominal pain lower 30.56 10.68 48 273655 21133 46391226
Bone cyst 30.47 10.68 48 273655 2003 46410356
Amnesia 30.35 10.68 133 273570 41498 46370861
Mydriasis 30.19 10.68 12 273691 10541 46401818
Blood albumin decreased 30.03 10.68 22 273681 13723 46398636
Heart rate irregular 29.92 10.68 39 273664 18552 46393807
Folliculitis 29.76 10.68 92 273611 6111 46406248
Ageusia 29.75 10.68 15 273688 11457 46400902
Shock haemorrhagic 29.72 10.68 7 273696 8617 46403742
Anal incontinence 29.66 10.68 16 273687 11762 46400597
Cough 29.56 10.68 1078 272625 229171 46183188
Thyroid neoplasm 29.51 10.68 66 273637 3603 46408756
Amenorrhoea 29.15 10.68 8 273695 8887 46403472
Uterine perforation 29.14 10.68 4 273699 7263 46405096
Device issue 29.10 10.68 45 273658 19935 46392424
Psychomotor hyperactivity 29.07 10.68 10 273693 9603 46402756
Limb operation 29.07 10.68 62 273641 3276 46409083
Disease susceptibility 29.01 10.68 17 273686 191 46412168
Crohn's disease 28.95 10.68 3 273700 6768 46405591
Malnutrition 28.59 10.68 24 273679 13979 46398380
Incontinence 28.57 10.68 11 273692 9851 46402508
Hypersomnia 28.51 10.68 29 273674 15410 46396949
Thrombosis 28.39 10.68 202 273501 55867 46356492
Hepatic encephalopathy 28.33 10.68 12 273691 10145 46402214
Fatigue 28.28 10.68 4024 269679 604673 45807686
Intestinal sepsis 28.28 10.68 18 273685 237 46412122
Medication error 28.24 10.68 90 273613 30821 46381538
Electrocardiogram U-wave abnormality 28.15 10.68 11 273692 44 46412315
Skin reaction 28.11 10.68 133 273570 10813 46401546
Osteopenia 28.07 10.68 183 273520 16778 46395581
Urine output decreased 28.05 10.68 15 273688 11082 46401277
Stress at work 27.99 10.68 32 273671 975 46411384
Graft versus host disease 27.96 10.68 3 273700 6585 46405774
Peritonitis bacterial 27.96 10.68 8 273695 8645 46403714
Hyperthyroidism 27.93 10.68 17 273686 11694 46400665
Epigastric discomfort 27.92 10.68 85 273618 5599 46406760
Transfusion 27.85 10.68 22 273681 13209 46399150
Heart rate increased 27.80 10.68 292 273411 74499 46337860
Retinitis 27.76 10.68 21 273682 371 46411988
Sinus bradycardia 27.67 10.68 24 273679 13758 46398601
Sinus tachycardia 27.65 10.68 53 273650 21596 46390763
Lip swelling 27.61 10.68 68 273635 25327 46387032
Pulmonary haemosiderosis 27.52 10.68 9 273694 18 46412341
Pulmonary hypertension 27.46 10.68 113 273590 35880 46376479
Faecaloma 27.30 10.68 6 273697 7746 46404613
Nonalcoholic fatty liver disease 27.04 10.68 28 273675 761 46411598
Drug reaction with eosinophilia and systemic symptoms 27.02 10.68 86 273617 29462 46382897
Acute coronary syndrome 26.98 10.68 13 273690 10191 46402168
Acidosis 26.96 10.68 16 273687 11158 46401201
Cholecystitis chronic 26.82 10.68 14 273689 10485 46401874
Leukocytosis 26.75 10.68 61 273642 23337 46389022
Eye swelling 26.75 10.68 48 273655 20055 46392304
Mass excision 26.69 10.68 18 273685 263 46412096
Dialysis 26.58 10.68 13 273690 10103 46402256
Blood creatine phosphokinase increased 26.55 10.68 79 273624 27645 46384714
Polyuria 26.52 10.68 5 273698 7190 46405169
Lupus myocarditis 26.37 10.68 11 273692 54 46412305
Obstructive airways disorder 26.15 10.68 24 273679 13388 46398971
Bradyphrenia 26.03 10.68 3 273700 6227 46406132
Brain oedema 25.95 10.68 21 273682 12457 46399902
Lipase increased 25.93 10.68 9 273694 8594 46403765
Intestinal obstruction 25.92 10.68 73 273630 26002 46386357
Eosinophil count increased 25.92 10.68 7 273696 7859 46404500
Abnormal dreams 25.83 10.68 14 273689 10265 46402094
Feeling cold 25.72 10.68 44 273659 18727 46393632
Drug effective for unapproved indication 25.61 10.68 38 273665 1504 46410855
Renal disorder 25.59 10.68 76 273627 26610 46385749
Cartilage atrophy 25.56 10.68 15 273688 169 46412190
Skin ulcer 25.53 10.68 297 273406 32161 46380198
Petechiae 25.52 10.68 22 273681 12648 46399711
Subarachnoid haemorrhage 25.49 10.68 17 273686 11136 46401223
Cellulitis 25.49 10.68 276 273427 70012 46342347
Aspiration 25.42 10.68 12 273691 9519 46402840
Hypoalbuminaemia 25.15 10.68 14 273689 10113 46402246
Adrenal insufficiency 25.12 10.68 147 273556 12977 46399382
Irritable bowel syndrome 24.83 10.68 174 273529 16341 46396018
General physical health deterioration 24.77 10.68 504 273199 115265 46297094
Cataract 24.76 10.68 389 273314 45026 46367333
Large intestine perforation 24.50 10.68 7 273696 7573 46404786
Subdural haematoma 24.48 10.68 24 273679 12973 46399386
Hypocalcaemia 24.46 10.68 78 273625 26707 46385652
Angina pectoris 24.43 10.68 78 273625 26697 46385662
Delusion 24.32 10.68 18 273685 11170 46401189
Long QT syndrome 24.32 10.68 55 273648 3025 46409334
Faeces discoloured 24.26 10.68 38 273665 16749 46395610
Paraesthesia oral 24.25 10.68 20 273683 11753 46400606
Bronchopleural fistula 24.18 10.68 16 273687 226 46412133
Haemodialysis 23.98 10.68 12 273691 9205 46403154
Antiphospholipid syndrome 23.97 10.68 39 273664 1673 46410686
Hallucination, auditory 23.78 10.68 17 273686 10739 46401620
Stress cardiomyopathy 23.71 10.68 8 273695 7776 46404583
Secretion discharge 23.66 10.68 112 273591 9107 46403252
Histoplasmosis disseminated 23.64 10.68 31 273672 1091 46411268
Cholecystitis 23.64 10.68 30 273673 14436 46397923
Retching 23.58 10.68 25 273678 13032 46399327
Pleuritic pain 23.57 10.68 87 273616 6329 46406030
Mycobacterium tuberculosis complex test positive 23.54 10.68 37 273666 1541 46410818
Metastases to lung 23.52 10.68 17 273686 10679 46401680
Infected seroma 23.36 10.68 10 273693 53 46412306
Supraventricular tachycardia 23.31 10.68 26 273677 13244 46399115
Fundoscopy abnormal 23.28 10.68 7 273696 9 46412350
Wound infection 23.15 10.68 121 273582 10238 46402121
Muscle spasticity 23.11 10.68 130 273573 11310 46401049
Orthostatic hypotension 23.09 10.68 71 273632 24587 46387772
Limb deformity 23.01 10.68 59 273644 3517 46408842
Dermatomyositis 23 10.68 42 273661 1979 46410380
Incorrect dosage administered 22.98 10.68 38 273665 1653 46410706
Antinuclear antibody positive 22.94 10.68 85 273618 6195 46406164
Peritonitis 22.88 10.68 55 273648 20659 46391700
Prothrombin time prolonged 22.79 10.68 14 273689 9582 46402777
Neoplasm malignant 22.66 10.68 224 273479 23275 46389084
Hip fracture 22.43 10.68 80 273623 26476 46385883
Aplastic anaemia 22.41 10.68 7 273696 7146 46405213
Cardiomyopathy 22.24 10.68 166 273537 15907 46396452
COVID-19 treatment 22.04 10.68 13 273690 148 46412211
Infective tenosynovitis 22.02 10.68 15 273688 223 46412136
Anhedonia 21.99 10.68 17 273686 10318 46402041
Pollakiuria 21.91 10.68 71 273632 24190 46388169
Bloody discharge 21.85 10.68 28 273675 963 46411396
Haemodynamic instability 21.75 10.68 9 273694 7716 46404643
Night sweats 21.72 10.68 250 273453 27000 46385359
Diabetic eye disease 21.67 10.68 13 273690 153 46412206
Metastases to lymph nodes 21.67 10.68 6 273697 6625 46405734
Tuberculosis 21.64 10.68 118 273585 10147 46402212
Metabolic encephalopathy 21.61 10.68 3 273700 5400 46406959
Sensory disturbance 21.58 10.68 24 273679 12243 46400116
Hiatus hernia 21.51 10.68 47 273656 18255 46394104
Synovial fluid analysis 21.50 10.68 33 273670 1346 46411013
Infective exacerbation of bronchiectasis 21.43 10.68 18 273685 372 46411987
Panic attack 21.38 10.68 55 273648 20187 46392172
Incorrect product administration duration 21.35 10.68 15 273688 9562 46402797
Neck surgery 21.34 10.68 34 273669 1433 46410926
Haematotoxicity 21.34 10.68 7 273696 6926 46405433
Therapy cessation 21.33 10.68 82 273621 26547 46385812
Enterocolitis 21.27 10.68 5 273698 6163 46406196
Mycobacterial infection 21.26 10.68 36 273667 1597 46410762
West Nile viral infection 21.23 10.68 18 273685 377 46411982
Skin exfoliation 21.21 10.68 110 273593 32828 46379531
Asphyxia 21.20 10.68 3 273700 5323 46407036
Brain injury 21.18 10.68 5 273698 6145 46406214
Colitis ischaemic 21.14 10.68 17 273686 10115 46402244
Ear pain 21.02 10.68 210 273493 21882 46390477
Cardiogenic shock 21.02 10.68 40 273663 16344 46396015
Hypertension 20.96 10.68 939 272764 195417 46216942
Clostridium difficile infection 20.95 10.68 76 273627 25027 46387332
Dystonia 20.95 10.68 21 273682 11236 46401123
Oral discomfort 20.91 10.68 97 273606 7821 46404538
Cholecystitis acute 20.87 10.68 9 273694 7529 46404830
Eyelid oedema 20.84 10.68 18 273685 10339 46402020
Large intestine polyp 20.81 10.68 10 273693 7851 46404508
Haemoptysis 20.75 10.68 81 273622 26108 46386251
Salivary hypersecretion 20.75 10.68 6 273697 6439 46405920
Unintended pregnancy 20.72 10.68 4 273699 5656 46406703
Butterfly rash 20.66 10.68 27 273676 947 46411412
Systemic lupus erythematosus rash 20.63 10.68 31 273672 1241 46411118
Bacteraemia 20.58 10.68 32 273671 14147 46398212
Glomerular filtration rate decreased 20.44 10.68 23 273680 11671 46400688
Tenosynovitis stenosans 20.31 10.68 39 273664 1910 46410449
Respiratory disorder 20.24 10.68 247 273456 27053 46385306
Hypovolaemia 20.12 10.68 17 273686 9871 46402488
Caesarean section 20.04 10.68 42 273661 16561 46395798
Failure to thrive 20.04 10.68 7 273696 6657 46405702
Agranulocytosis 19.98 10.68 65 273638 22120 46390239
Frequent bowel movements 19.82 10.68 27 273676 12605 46399754
White blood cell count increased 19.71 10.68 165 273538 44054 46368305
Bursitis 19.56 10.68 190 273513 19652 46392707
Weight increased 19.55 10.68 777 272926 163696 46248663
Bursitis infective 19.54 10.68 29 273674 1148 46411211
Arteriosclerosis 19.48 10.68 17 273686 9716 46402643
Acute pulmonary oedema 19.46 10.68 11 273692 7880 46404479
Larynx irritation 19.45 10.68 11 273692 115 46412244
Activated partial thromboplastin time prolonged 19.44 10.68 8 273695 6881 46405478
Myocardial ischaemia 19.26 10.68 28 273675 12721 46399638
Gingivitis 19.25 10.68 10 273693 7510 46404849
Chondrodystrophy 19.24 10.68 10 273693 87 46412272
Product adhesion issue 19.24 10.68 3 273700 4952 46407407
Premature delivery 19.21 10.68 206 273497 21863 46390496
Stevens-Johnson syndrome 19.14 10.68 71 273632 23226 46389133
Hot flush 19.12 10.68 163 273540 43354 46369005
Inflammatory marker increased 19.08 10.68 73 273630 5402 46406957
Cutaneous sarcoidosis 19.03 10.68 16 273687 331 46412028
Pericardial effusion 18.98 10.68 81 273622 25462 46386897
Application site erythema 18.97 10.68 3 273700 4901 46407458
Pemphigoid 18.88 10.68 5 273698 5686 46406673
Post procedural haemorrhage 18.83 10.68 10 273693 7416 46404943
Diplopia 18.80 10.68 55 273648 19350 46393009
Ataxia 18.77 10.68 33 273670 13897 46398462
Face oedema 18.76 10.68 54 273649 19099 46393260
Visual field defect 18.71 10.68 78 273625 6005 46406354
Infusion site pain 18.65 10.68 19 273684 10088 46402271
Hyperreflexia 18.64 10.68 4 273699 5250 46407109
Thinking abnormal 18.62 10.68 18 273685 9796 46402563
Retinal deposits 18.61 10.68 9 273694 66 46412293
Diverticulum 18.56 10.68 23 273680 11183 46401176
Lymphoedema 18.53 10.68 14 273689 8598 46403761
Thrombotic microangiopathy 18.53 10.68 13 273690 8293 46404066
Androgenetic alopecia 18.48 10.68 12 273691 164 46412195
Hypergammaglobulinaemia 18.47 10.68 18 273685 454 46411905
Pancreatitis acute 18.41 10.68 79 273624 24793 46387566
Proctalgia 18.41 10.68 3 273700 4793 46407566
Migraine 18.40 10.68 294 273409 69732 46342627
Renal phospholipidosis 18.39 10.68 5 273698 3 46412356
Right ventricular failure 18.36 10.68 42 273661 16051 46396308
Lower gastrointestinal haemorrhage 18.35 10.68 10 273693 7310 46405049
Mycotic allergy 18.30 10.68 19 273684 518 46411841
Rash erythematous 18.25 10.68 122 273581 34228 46378131
Device breakage 18.13 10.68 18 273685 9674 46402685
Creatinine urine abnormal 18.11 10.68 7 273696 27 46412332
Monocyte count increased 18.05 10.68 68 273635 4996 46407363
Cranial nerve injury 18.03 10.68 6 273697 13 46412346
Anterior chamber cleavage syndrome 17.99 10.68 12 273691 172 46412187
Cerebral atrophy 17.99 10.68 3 273700 4713 46407646
Taste disorder 17.97 10.68 6 273697 5872 46406487
Skin discolouration 17.90 10.68 115 273588 32565 46379794
Pancreatic carcinoma 17.89 10.68 8 273695 6549 46405810
Device use error 17.76 10.68 4 273699 5077 46407282
Hyperbilirubinaemia 17.74 10.68 21 273682 10417 46401942
Ganglioneuroma 17.67 10.68 11 273692 139 46412220
Pulseless electrical activity 17.66 10.68 10 273693 7157 46405202
Skin burning sensation 17.65 10.68 22 273681 10670 46401689
Ocular sarcoidosis 17.54 10.68 7 273696 30 46412329
Nephropathy toxic 17.53 10.68 11 273692 7443 46404916
Localised infection 17.49 10.68 215 273488 23586 46388773
Lipidosis 17.44 10.68 6 273697 15 46412344
Intervertebral disc compression 17.43 10.68 25 273678 959 46411400
Coma scale abnormal 17.38 10.68 4 273699 5002 46407357
Middle lobe syndrome 17.36 10.68 7 273696 31 46412328
Fistula 17.27 10.68 13 273690 7997 46404362
Fracture 17.21 10.68 45 273658 16426 46395933
Carpal tunnel syndrome 17.20 10.68 155 273548 15704 46396655
Gait inability 17.14 10.68 296 273407 34907 46377452
Myelodysplastic syndrome 17.13 10.68 42 273661 15669 46396690
C-reactive protein 17.08 10.68 15 273688 330 46412029
Infusion site erythema 17.00 10.68 12 273691 7630 46404729
Drug resistance 16.99 10.68 49 273654 17319 46395040
Body tinea 16.92 10.68 24 273679 911 46411448
Hospice care 16.91 10.68 5 273698 5290 46407069
Premature labour 16.88 10.68 25 273678 11274 46401085
Pregnancy with contraceptive device 16.88 10.68 3 273700 4500 46407859
Thyroid disorder 16.86 10.68 125 273578 11951 46400408
Hyperventilation 16.86 10.68 6 273697 5641 46406718
Night blindness 16.82 10.68 15 273688 337 46412022
Intervertebral disc space narrowing 16.81 10.68 23 273680 844 46411515
Oliguria 16.70 10.68 16 273687 8743 46403616
Transplant rejection 16.64 10.68 19 273684 9577 46402782
Device occlusion 16.62 10.68 7 273696 5938 46406421
Product use in unapproved indication 16.59 10.68 667 273036 89606 46322753
Alanine aminotransferase abnormal 16.58 10.68 42 273661 2485 46409874
Cold sweat 16.57 10.68 24 273679 10921 46401438
Hypoacusis 16.52 10.68 65 273638 20904 46391455
Diarrhoea haemorrhagic 16.43 10.68 12 273691 7497 46404862
Adenoiditis 16.36 10.68 7 273696 37 46412322
Mycobacterium marinum infection 16.36 10.68 10 273693 122 46412237
Injury 16.31 10.68 172 273531 43855 46368504
Allergy to vaccine 16.24 10.68 11 273692 162 46412197
Muscle tightness 16.19 10.68 22 273681 10283 46402076
Placenta accreta 16.18 10.68 11 273692 163 46412196
Pruritus allergic 16.18 10.68 25 273678 1026 46411333
Lip ulceration 16.17 10.68 33 273670 1690 46410669
Pelvic pain 16.08 10.68 27 273676 11575 46400784
Obesity 16.00 10.68 140 273563 14066 46398293
Psoriasis 15.98 10.68 345 273358 78259 46334100
Diaphragm muscle weakness 15.97 10.68 6 273697 21 46412338
Retinogram abnormal 15.95 10.68 10 273693 128 46412231
Loss of consciousness 15.91 10.68 498 273205 107740 46304619
Granulomatous dermatitis 15.76 10.68 9 273694 96 46412263
Hepatic enzyme abnormal 15.75 10.68 58 273645 4214 46408145
Hepatitis 15.73 10.68 271 273432 31944 46380415
Chromaturia 15.72 10.68 41 273662 14978 46397381
Smear cervix abnormal 15.67 10.68 41 273662 2475 46409884
Central nervous system lesion 15.65 10.68 20 273683 9595 46402764
Gonorrhoea 15.63 10.68 10 273693 133 46412226
Jaundice cholestatic 15.61 10.68 5 273698 5024 46407335
Pathogen resistance 15.60 10.68 8 273695 6052 46406307
No adverse event 15.59 10.68 127 273576 34104 46378255
Venoocclusive liver disease 15.57 10.68 3 273700 4248 46408111
Presyncope 15.56 10.68 82 273621 24372 46387987
Gastroenteritis 15.53 10.68 81 273622 24138 46388221
Arteriosclerosis coronary artery 15.43 10.68 15 273688 8141 46404218
Gastric disorder 15.42 10.68 231 273472 26474 46385885
Apathy 15.41 10.68 12 273691 7256 46405103
Urticarial vasculitis 15.36 10.68 16 273687 438 46411921
Eye pruritus 15.30 10.68 29 273674 11869 46400490
Oesophagitis 15.27 10.68 36 273667 13615 46398744
Hyperinsulinaemic hypoglycaemia 15.24 10.68 7 273696 45 46412314
Sudden death 15.23 10.68 20 273683 9484 46402875
Femoral neck fracture 15.22 10.68 15 273688 8088 46404271
Congenital osteodystrophy 15.16 10.68 6 273697 25 46412334
Wrong product administered 15.15 10.68 7 273696 5623 46406736
Antinuclear antibody negative 15.13 10.68 12 273691 228 46412131
Fracture delayed union 15.09 10.68 37 273666 2145 46410214
Hepatic necrosis 15.02 10.68 7 273696 5594 46406765
Hypercalcaemia 14.99 10.68 189 273514 20857 46391502
Dyspnoea exertional 14.99 10.68 206 273497 50083 46362276
Rash macular 14.98 10.68 60 273643 19200 46393159
Drug level decreased 14.93 10.68 8 273695 5904 46406455
Visual acuity reduced 14.72 10.68 73 273630 22040 46390319
Cardiac septal hypertrophy 14.71 10.68 8 273695 77 46412282
Dermatitis allergic 14.61 10.68 125 273578 12478 46399881
Hypotonia 14.59 10.68 16 273687 8213 46404146
Respiratory acidosis 14.56 10.68 9 273694 6139 46406220
Cyst 14.56 10.68 121 273582 11979 46400380
Tendon disorder 14.55 10.68 63 273640 4932 46407427
Gastrointestinal toxicity 14.49 10.68 57 273646 4274 46408085
Product preparation error 14.48 10.68 3 273700 4036 46408323
Lupus-like syndrome 14.46 10.68 87 273616 7757 46404602
White blood cell count abnormal 14.41 10.68 6 273697 5126 46407233
Application site pain 14.40 10.68 3 273700 4020 46408339
Multiple allergies 14.39 10.68 83 273620 7288 46405071
Hypertensive crisis 14.38 10.68 37 273666 13578 46398781
Blood pressure inadequately controlled 14.37 10.68 4 273699 4402 46407957
Iodine allergy 14.34 10.68 17 273686 539 46411820
Nausea 14.30 10.68 3698 270005 683756 45728603
Diffuse alopecia 14.24 10.68 17 273686 543 46411816
Lyme disease 14.20 10.68 38 273665 2325 46410034
Haemolysis 14.17 10.68 9 273694 6050 46406309
Fear 14.14 10.68 48 273655 16124 46396235
Klebsiella infection 14.12 10.68 11 273692 6651 46405708
Hyperuricaemia 14.10 10.68 5 273698 4712 46407647
Multiple system atrophy 14.09 10.68 11 273692 204 46412155
Toxic encephalopathy 14.09 10.68 6 273697 5056 46407303
Coronary artery stenosis 14.08 10.68 5 273698 4708 46407651
Troponin increased 14.07 10.68 15 273688 7801 46404558
Weight decreased 14.03 10.68 1055 272648 209794 46202565
Hemiplegia 14.03 10.68 12 273691 6926 46405433
Palindromic rheumatism 13.98 10.68 9 273694 121 46412238
Clear cell renal cell carcinoma 13.98 10.68 23 273680 996 46411363
Device leakage 13.94 10.68 7 273696 5358 46407001
Thirst 13.90 10.68 27 273676 10949 46401410
Overwork 13.86 10.68 7 273696 57 46412302
Partial seizures 13.84 10.68 6 273697 5004 46407355
Retinal injury 13.82 10.68 11 273692 210 46412149
Throat tightness 13.82 10.68 68 273635 20571 46391788
Thrombophlebitis superficial 13.81 10.68 6 273697 4997 46407362
Scleritis 13.80 10.68 43 273660 2869 46409490
Hepatic lesion 13.76 10.68 3 273700 3894 46408465
Retinal disorder 13.73 10.68 28 273675 1433 46410926
Product residue present 13.68 10.68 3 273700 3879 46408480
Pulmonary sarcoidosis 13.68 10.68 21 273682 857 46411502
Hypercapnia 13.67 10.68 5 273698 4621 46407738
Impaired quality of life 13.67 10.68 46 273657 3196 46409163
Coombs positive haemolytic anaemia 13.66 10.68 14 273689 376 46411983
Precancerous cells present 13.63 10.68 25 273678 1182 46411177
Menstruation irregular 13.60 10.68 11 273692 6528 46405831
Product substitution issue 13.57 10.68 44 273659 14987 46397372
Pathological fracture 13.50 10.68 16 273687 7934 46404425
Eye pain 13.49 10.68 102 273601 27838 46384521
Retinal depigmentation 13.44 10.68 12 273691 270 46412089
Acute vestibular syndrome 13.42 10.68 5 273698 17 46412342
Stillbirth 13.40 10.68 11 273692 6480 46405879
Hypoaesthesia oral 13.35 10.68 26 273677 10533 46401826
Blood thyroid stimulating hormone increased 13.34 10.68 9 273694 5860 46406499
DNULL antibody 13.27 10.68 6 273697 37 46412322
Breast pain 13.20 10.68 15 273688 7579 46404780
Gastric ulcer haemorrhage 13.18 10.68 6 273697 4862 46407497
Blood calcium increased 13.18 10.68 15 273688 7572 46404787
Respiration abnormal 13.17 10.68 5 273698 4516 46407843
Incoherent 13.12 10.68 5 273698 4507 46407852
Injection site hypersensitivity 13.10 10.68 28 273675 1482 46410877
Respiratory syncytial virus infection 13.03 10.68 6 273697 4829 46407530
Major depression 13.01 10.68 12 273691 6678 46405681
Immunisation reaction 12.99 10.68 5 273698 19 46412340
Rheumatoid factor 12.99 10.68 7 273696 66 46412293
Biopsy heart abnormal 12.95 10.68 4 273699 6 46412353
Device malfunction 12.89 10.68 38 273665 13336 46399023
Hyperkeratosis 12.86 10.68 61 273642 4964 46407395
Internal haemorrhage 12.85 10.68 5 273698 4450 46407909
Arthritis bacterial 12.82 10.68 67 273636 5669 46406690
External auditory canal atresia 12.81 10.68 7 273696 68 46412291
Transient hypogammaglobulinaemia of infancy 12.76 10.68 6 273697 41 46412318
Lung infiltration 12.75 10.68 41 273662 14002 46398357
Staphylococcal infection 12.75 10.68 141 273562 35630 46376729
Palmoplantar pustulosis 12.75 10.68 13 273690 347 46412012
Electrocardiogram ST segment elevation 12.73 10.68 3 273700 3692 46408667
Ischaemia 12.71 10.68 5 273698 4419 46407940
Foetal exposure during pregnancy 12.70 10.68 117 273586 30630 46381729
Therapy change 12.69 10.68 7 273696 5083 46407276
Dysphonia 12.69 10.68 154 273549 38260 46374099
Red blood cell count decreased 12.68 10.68 126 273577 32497 46379862
Peripheral sensory neuropathy 12.66 10.68 12 273691 6591 46405768
Complement factor C3 decreased 12.60 10.68 9 273694 145 46412214
Culture tissue specimen positive 12.58 10.68 4 273699 7 46412352
Skin toxicity 12.53 10.68 3 273700 3651 46408708
Angioedema 12.51 10.68 159 273544 39183 46373176
Blood urine present 12.50 10.68 34 273669 12248 46400111
Gastroenteritis cryptosporidial 12.47 10.68 7 273696 72 46412287
COVID-19 12.47 10.68 165 273538 18410 46393949
Somnambulism 12.45 10.68 7 273696 5030 46407329
Application site pruritus 12.44 10.68 4 273699 4009 46408350
Lupus pancreatitis 12.44 10.68 3 273700 0 46412359
Clostridial infection 12.43 10.68 5 273698 4360 46407999
Gluten sensitivity 12.37 10.68 15 273688 487 46411872
Delusional disorder, persecutory type 12.34 10.68 9 273694 150 46412209
Expired product administered 12.28 10.68 9 273694 5613 46406746
Lupus enteritis 12.23 10.68 7 273696 75 46412284
Bronchospasm 12.17 10.68 49 273654 15658 46396701
Heparin-induced thrombocytopenia 12.16 10.68 5 273698 4304 46408055
Ketoacidosis 12.16 10.68 4 273699 3951 46408408
Incorrect route of product administration 12.14 10.68 52 273651 16331 46396028
Aplasia 12.13 10.68 3 273700 3573 46408786
Dermatitis contact 12.11 10.68 18 273685 8105 46404254
Ovarian granulosa cell tumour 12.08 10.68 5 273698 24 46412335
Cornea verticillata 12.08 10.68 6 273697 47 46412312
Polyneuropathy 12.02 10.68 32 273671 11612 46400747
Motor dysfunction 12.00 10.68 15 273688 7267 46405092
Monocyte count abnormal 11.97 10.68 10 273693 205 46412154
Drug screen positive 11.85 10.68 4 273699 3887 46408472
Neuralgia 11.84 10.68 75 273628 21308 46391051
Needle issue 11.78 10.68 10 273693 5794 46406565
Duodenal ulcer 11.76 10.68 15 273688 7203 46405156
Infected varicose vein 11.76 10.68 5 273698 26 46412333
Hydronephrosis 11.73 10.68 20 273683 8525 46403834
Body temperature increased 11.73 10.68 208 273495 24653 46387706
Labelled drug-drug interaction medication error 11.73 10.68 22 273681 9039 46403320
Hypovolaemic shock 11.71 10.68 8 273695 5175 46407184
Anaphylactoid reaction 11.71 10.68 3 273700 3488 46408871
Oral herpes 11.70 10.68 169 273534 19221 46393138
Complement factor C4 decreased 11.70 10.68 7 273696 82 46412277
Myocarditis 11.68 10.68 17 273686 7722 46404637
Vaginal haematoma 11.68 10.68 8 273695 120 46412239
Quality of life decreased 11.65 10.68 65 273638 5637 46406722
Hallucinations, mixed 11.65 10.68 4 273699 3845 46408514
Exposure via ingestion 11.59 10.68 3 273700 3464 46408895
Pleuropericarditis 11.58 10.68 10 273693 215 46412144
Brain neoplasm 11.53 10.68 4 273699 3820 46408539
Ejection fraction decreased 11.50 10.68 60 273643 17877 46394482
Throat irritation 11.50 10.68 111 273592 28790 46383569
Functional gastrointestinal disorder 11.47 10.68 43 273660 3151 46409208
Rash papular 11.47 10.68 38 273665 12860 46399499
Spondyloarthropathy 11.47 10.68 17 273686 672 46411687
Neuropsychiatric lupus 11.46 10.68 8 273695 124 46412235
Pneumonia legionella 11.46 10.68 25 273678 1342 46411017
Immune reconstitution inflammatory syndrome 11.46 10.68 10 273693 5715 46406644
Atrioventricular block second degree 11.41 10.68 4 273699 3795 46408564
Cytomegalovirus viraemia 11.40 10.68 6 273697 4472 46407887
Forced expiratory volume decreased 11.37 10.68 8 273695 5096 46407263
Musculoskeletal chest pain 11.36 10.68 61 273642 18045 46394314
Neutrophil count increased 11.34 10.68 44 273659 14209 46398150
Gait disturbance 11.33 10.68 994 272709 144269 46268090
Apnoea 11.20 10.68 16 273687 7323 46405036
Dry mouth 11.18 10.68 241 273462 54685 46357674
Bacterial test positive 11.12 10.68 6 273697 4410 46407949
Erythematotelangiectatic rosacea 11.11 10.68 4 273699 12 46412347
Heart block congenital 11.11 10.68 4 273699 12 46412347
Facial bones fracture 11.09 10.68 3 273700 3365 46408994
Anticoagulation drug level increased 11.09 10.68 9 273694 177 46412182
Fluid intake reduced 11.08 10.68 3 273700 3363 46408996
Productive cough 11.07 10.68 220 273483 50495 46361864
Hypoxic-ischaemic encephalopathy 11.06 10.68 5 273698 4068 46408291
Eructation 11.04 10.68 16 273687 7279 46405080
Eyelid ptosis 11.00 10.68 12 273691 6176 46406183
HLA marker study positive 11.00 10.68 9 273694 179 46412180
Histoplasmosis 11.00 10.68 28 273675 1662 46410697
Hypomania 10.99 10.68 6 273697 4382 46407977
Injection site mass 10.99 10.68 48 273655 14992 46397367
Herpes simplex reactivation 10.97 10.68 12 273691 348 46412011
Herpes zoster cutaneous disseminated 10.94 10.68 8 273695 134 46412225
Encephalitis 10.92 10.68 78 273625 7370 46404989
Cardiomegaly 10.91 10.68 59 273644 17423 46394936
Skin papilloma 10.91 10.68 51 273652 4125 46408234
Blood loss anaemia 10.88 10.68 21 273682 8536 46403823
Mouth swelling 10.88 10.68 4 273699 3685 46408674
COVID-19 pneumonia 10.87 10.68 43 273660 3232 46409127
Serum ferritin increased 10.85 10.68 9 273694 5274 46407085
Cholangitis 10.85 10.68 7 273696 4667 46407692
Hepatitis B reactivation 10.82 10.68 26 273677 1488 46410871
Granulocytopenia 10.81 10.68 9 273694 5264 46407095
Myopathy 10.78 10.68 89 273614 8792 46403567
Muscle haemorrhage 10.78 10.68 3 273700 3301 46409058
Lacrimation increased 10.77 10.68 52 273651 15809 46396550
Dyslipidaemia 10.70 10.68 10 273693 5530 46406829

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 2443.09 13.09 1271 51976 39926 29859305
Off label use 2428.52 13.09 2567 50680 246723 29652508
Drug ineffective 1930.41 13.09 2664 50583 337723 29561508
Drug intolerance 1277.48 13.09 866 52381 44425 29854806
Joint swelling 1137.67 13.09 818 52429 46128 29853103
Synovitis 961.93 13.09 428 52819 9355 29889876
Contraindicated product administered 832.21 13.09 465 52782 16766 29882465
Treatment failure 691.31 13.09 538 52709 34141 29865090
Apparent death 505.24 13.09 202 53045 3340 29895891
Therapeutic product effect decreased 442.83 13.09 386 52861 28690 29870541
C-reactive protein abnormal 366.08 13.09 185 53062 5408 29893823
Arthropathy 335.46 13.09 285 52962 20442 29878789
Bone erosion 331.28 13.09 132 53115 2161 29897070
Diverticulitis 330.75 13.09 263 52984 17182 29882049
Arthralgia 318.13 13.09 727 52520 135064 29764167
Loss of personal independence in daily activities 292.30 13.09 268 52979 21267 29877964
Pain 287.37 13.09 812 52435 171829 29727402
Death 266.57 13.09 153 53094 357130 29542101
Red blood cell sedimentation rate increased 260.24 13.09 162 53085 7133 29892098
Red blood cell sedimentation rate abnormal 248.85 13.09 100 53147 1675 29897556
Electrocardiogram QT prolonged 230.64 13.09 301 52946 35534 29863697
Mobility decreased 225.43 13.09 254 52993 25745 29873486
Musculoskeletal stiffness 210.40 13.09 288 52959 35593 29863638
Sleep disorder due to general medical condition, insomnia type 197.37 13.09 76 53171 1130 29898101
Hand deformity 190.54 13.09 84 53163 1789 29897442
Impaired work ability 190.44 13.09 121 53126 5522 29893709
Condition aggravated 186.18 13.09 603 52644 137263 29761968
Therapeutic product effect incomplete 181.13 13.09 260 52987 33574 29865657
Long QT syndrome 172.91 13.09 84 53163 2249 29896982
Rheumatoid factor positive 166.70 13.09 54 53193 465 29898766
Drug effective for unapproved indication 161.30 13.09 64 53183 1035 29898196
Febrile neutropenia 159.89 13.09 7 53240 106686 29792545
Knee arthroplasty 156.62 13.09 107 53140 5523 29893708
C-reactive protein increased 155.54 13.09 278 52969 43195 29856036
Peripheral swelling 154.91 13.09 338 52909 60736 29838495
Drug hypersensitivity 154.64 13.09 362 52885 68157 29831074
Hepatitis 153.54 13.09 194 53053 22162 29877069
Onychoclasis 142.12 13.09 66 53181 1593 29897638
Pulmonary thrombosis 140.64 13.09 105 53142 6238 29892993
COVID-19 138.71 13.09 165 53082 17713 29881518
Rheumatoid factor negative 131.91 13.09 46 53201 507 29898724
Lymphoma 131.53 13.09 123 53124 9998 29889233
Anaemia 121.06 13.09 115 53132 207877 29691354
Drug specific antibody present 120.31 13.09 63 53184 1984 29897247
Intentional product use issue 118.92 13.09 224 53023 36216 29863015
Product use in unapproved indication 118.56 13.09 343 52904 73350 29825881
Osteoarthritis 113.14 13.09 151 53096 18198 29881033
Dehydration 111.80 13.09 40 53207 123499 29775732
Herpes zoster 111.60 13.09 195 53052 29748 29869483
Terminal state 111.06 13.09 73 53174 3531 29895700
Limb discomfort 110.01 13.09 106 53141 8944 29890287
Drug tolerance decreased 109.30 13.09 49 53198 1087 29898144
Joint stiffness 108.84 13.09 107 53140 9254 29889977
Joint lock 108.66 13.09 48 53199 1027 29898204
Gastrointestinal disorder 107.16 13.09 185 53062 27952 29871279
Acne cystic 106.43 13.09 38 53209 451 29898780
Hypotension 102.09 13.09 124 53123 200441 29698790
Tooth loss 100.02 13.09 71 53176 3898 29895333
Constipation 98.07 13.09 39 53208 112867 29786364
Polyarthritis 97.79 13.09 65 53182 3204 29896027
Drug abuse 96.94 13.09 15 53232 82057 29817174
Systemic lupus erythematosus 96.83 13.09 59 53188 2497 29896734
Arthritis 92.34 13.09 160 53087 24241 29874990
Mass 91.29 13.09 86 53161 7054 29892177
Acute kidney injury 91.16 13.09 222 53025 273620 29625611
Decreased appetite 90.56 13.09 80 53167 149830 29749401
Disability 88.83 13.09 69 53178 4349 29894882
Toxicity to various agents 88.60 13.09 111 53136 177072 29722159
Diarrhoea 88.49 13.09 302 52945 333801 29565430
Malignant neoplasm progression 88.18 13.09 12 53235 72275 29826956
Anti-cyclic citrullinated peptide antibody positive 87.88 13.09 37 53210 701 29898530
Seizure 87.19 13.09 33 53214 98442 29800789
Photosensitivity reaction 84.46 13.09 95 53152 9599 29889632
Physical disability 84.44 13.09 41 53206 1096 29898135
Bone cyst 84.41 13.09 33 53214 512 29898719
Overdose 83.96 13.09 23 53224 84314 29814917
Nodule 83.94 13.09 69 53178 4719 29894512
X-ray abnormal 82.29 13.09 32 53215 489 29898742
Vomiting 81.42 13.09 168 53079 219650 29679581
Intestinal polyp 80.79 13.09 37 53210 864 29898367
Rheumatoid nodule 77.12 13.09 44 53203 1646 29897585
Drug use disorder 77.03 13.09 56 53191 3192 29896039
Confusional state 76.65 13.09 76 53171 134758 29764473
Pyrexia 76.02 13.09 269 52978 294220 29605011
Cytology abnormal 75.57 13.09 28 53219 372 29898859
Bladder transitional cell carcinoma 71.51 13.09 48 53199 2405 29896826
Joint arthroplasty 69.90 13.09 30 53217 597 29898634
Blood glucose increased 68.78 13.09 13 53234 61517 29837714
COVID-19 pneumonia 68.46 13.09 60 53187 4480 29894751
Hip arthroplasty 67.88 13.09 55 53192 3685 29895546
Alopecia 66.00 13.09 121 53126 19154 29880077
Foot deformity 65.48 13.09 52 53195 3385 29895846
Arthritis bacterial 65.33 13.09 58 53189 4406 29894825
Plasma cell myeloma 64.90 13.09 9 53238 53453 29845778
Abdominal pain 63.66 13.09 89 53158 135565 29763666
Intestinal sepsis 62.46 13.09 25 53222 414 29898817
Syncope 62.04 13.09 37 53210 84866 29814365
Coronavirus infection 60.46 13.09 50 53197 3448 29895783
Loss of consciousness 58.83 13.09 34 53213 79341 29819890
Hyperkalaemia 58.60 13.09 22 53225 65988 29833243
Pulmonary fibrosis 58.55 13.09 103 53144 15787 29883444
Rhabdomyolysis 58.47 13.09 20 53227 63560 29835671
Deep vein thrombosis 57.96 13.09 237 53010 60264 29838967
Hypertransaminasaemia 57.89 13.09 51 53196 3834 29895397
Musculoskeletal pain 57.60 13.09 152 53095 30788 29868443
Neoplasm malignant 57.45 13.09 109 53138 17705 29881526
COVID-19 treatment 56.67 13.09 21 53226 279 29898952
Psoriatic arthropathy 56.58 13.09 101 53146 15660 29883571
Completed suicide 55.46 13.09 57 53190 99435 29799796
Fall 54.63 13.09 155 53092 181717 29717514
Ill-defined disorder 52.33 13.09 78 53169 10406 29888825
Blood creatinine increased 51.32 13.09 52 53195 91323 29807908
Prerenal failure 50.71 13.09 35 53212 1836 29897395
Pain in extremity 49.21 13.09 350 52897 109871 29789360
Gait inability 48.52 13.09 105 53142 18736 29880495
General physical health deterioration 48.45 13.09 64 53183 99880 29799351
Hospitalisation 48.19 13.09 10 53237 44309 29854922
Therapeutic response decreased 47.76 13.09 122 53125 24227 29875004
Dizziness 46.28 13.09 184 53063 194725 29704506
Drug ineffective for unapproved indication 46.01 13.09 75 53172 10805 29888426
Hallucination 45.86 13.09 15 53232 49044 29850187
Liver function test increased 45.66 13.09 76 53171 11140 29888091
Pulmonary embolism 43.94 13.09 263 52984 77872 29821359
Renal impairment 43.85 13.09 51 53196 84133 29815098
Lupus nephritis 43.82 13.09 17 53230 258 29898973
Gastric disorder 43.67 13.09 72 53175 10471 29888760
Oral surgery 43.61 13.09 21 53226 551 29898680
Basal cell carcinoma 43.04 13.09 91 53156 15977 29883254
Somnolence 42.90 13.09 66 53181 96697 29802534
Platelet count decreased 42.78 13.09 77 53170 106052 29793179
Infection 42.76 13.09 261 52986 77813 29821418
Skin mass 42.72 13.09 41 53206 3441 29895790
Urinary tract infection 42.41 13.09 41 53206 73618 29825613
Foetal exposure during pregnancy 42.31 13.09 153 53094 36718 29862513
Coma 42.22 13.09 10 53237 40439 29858792
Medical device implantation 41.87 13.09 20 53227 515 29898716
Inflammation 41.80 13.09 109 53138 21917 29877314
Agitation 41.74 13.09 22 53225 54051 29845180
Type 2 lepra reaction 41.45 13.09 18 53229 369 29898862
Aggression 40.81 13.09 8 53239 36899 29862332
Premature baby 40.69 13.09 91 53156 16600 29882631
Dyspnoea 40.21 13.09 389 52858 332906 29566325
Grip strength decreased 39.59 13.09 32 53215 2136 29897095
Epistaxis 38.81 13.09 23 53224 52958 29846273
Dactylitis 38.17 13.09 18 53229 450 29898781
Soft tissue swelling 37.72 13.09 15 53232 244 29898987
Limb deformity 37.49 13.09 18 53229 469 29898762
Thrombocytopenia 37.39 13.09 122 53125 136922 29762309
C-reactive protein decreased 36.95 13.09 27 53220 1551 29897680
Skin ulcer 36.50 13.09 94 53153 18755 29880476
Anxiety 36.39 13.09 65 53182 89806 29809425
Immobile 35.94 13.09 30 53217 2096 29897135
Ascites 35.34 13.09 10 53237 35911 29863320
Cardiac arrest 35.10 13.09 70 53177 92780 29806451
Gastrointestinal haemorrhage 35.02 13.09 59 53188 83387 29815844
External auditory canal atresia 34.35 13.09 12 53235 133 29899098
Hyperglycaemia 34.26 13.09 10 53237 35190 29864041
Seronegative arthritis 34.00 13.09 20 53227 793 29898438
Disease progression 33.96 13.09 56 53191 79818 29819413
Malaise 33.93 13.09 167 53080 166795 29732436
Heart block congenital 33.39 13.09 9 53238 37 29899194
Neutrophil count decreased 33.16 13.09 17 53230 42437 29856794
Drug dependence 33.11 13.09 98 53149 21197 29878034
Pneumonia aspiration 32.84 13.09 13 53234 37767 29861464
Neutropenia 32.64 13.09 118 53129 128422 29770809
Hepatic function abnormal 32.46 13.09 17 53230 41928 29857303
Metabolic acidosis 32.38 13.09 13 53234 37448 29861783
Dysphagia 32.12 13.09 32 53215 56666 29842565
Orthostatic hypotension 31.68 13.09 3 53244 23976 29875255
Skin laceration 31.63 13.09 65 53182 11186 29888045
Septic shock 31.56 13.09 40 53207 63567 29835664
Low birth weight baby 31.47 13.09 46 53201 6030 29893201
Blood urea increased 30.39 13.09 9 53238 31372 29867859
Lymphoedema 29.98 13.09 34 53213 3465 29895766
Microcephaly 29.82 13.09 17 53230 635 29898596
Blood pressure decreased 29.74 13.09 24 53223 47051 29852180
Blood pressure fluctuation 29.58 13.09 83 53164 17420 29881811
Vitamin D deficiency 29.51 13.09 41 53206 5129 29894102
Restlessness 29.40 13.09 3 53244 22596 29876635
International normalised ratio increased 29.35 13.09 25 53222 47714 29851517
Abdominal discomfort 29.20 13.09 167 53080 48624 29850607
Lethargy 29.16 13.09 17 53230 39502 29859729
Swelling 29.12 13.09 134 53113 35841 29863390
Cognitive disorder 28.71 13.09 4 53243 23686 29875545
Disorientation 28.67 13.09 10 53237 31408 29867823
Unresponsive to stimuli 28.64 13.09 6 53241 26413 29872818
Therapy partial responder 28.50 13.09 34 53213 3657 29895574
Liver injury 28.44 13.09 66 53181 12334 29886897
Dyskinesia 28.15 13.09 3 53244 21831 29877400
Cardiac failure 28.12 13.09 67 53180 83351 29815880
Fatigue 27.92 13.09 402 52845 320271 29578960
Sensitivity to weather change 27.70 13.09 22 53225 1432 29897799
Thrombosis 27.58 13.09 148 53099 42083 29857148
Fine motor skill dysfunction 27.49 13.09 20 53227 1141 29898090
Hepatic enzyme abnormal 26.83 13.09 26 53221 2208 29897023
Aspartate aminotransferase increased 26.46 13.09 45 53202 63377 29835854
Hypoglycaemia 26.41 13.09 31 53216 50950 29848281
Neck mass 26.35 13.09 21 53226 1374 29897857
Bone marrow failure 26.30 13.09 10 53237 29775 29869456
Respiratory arrest 25.54 13.09 10 53237 29248 29869983
Circulatory collapse 25.50 13.09 3 53244 20211 29879020
Irritability 25.47 13.09 5 53242 23045 29876186
Hypofibrinogenaemia 25.32 13.09 22 53225 1623 29897608
Blood bilirubin increased 25.32 13.09 17 53230 36619 29862612
Blood pressure systolic abnormal 24.92 13.09 21 53226 1486 29897745
Suicidal ideation 24.63 13.09 17 53230 36097 29863134
Cytomegalovirus infection 24.41 13.09 6 53241 23668 29875563
Ocular toxicity 24.32 13.09 10 53237 178 29899053
Hypophagia 24.20 13.09 5 53242 22231 29877000
Disturbance in attention 24.04 13.09 5 53242 22124 29877107
Intentional overdose 23.97 13.09 23 53224 41458 29857773
Infection reactivation 23.92 13.09 17 53230 935 29898296
Cerebrovascular accident 23.66 13.09 73 53174 83404 29815827
Abnormal behaviour 23.65 13.09 8 53239 25615 29873616
Cardio-respiratory arrest 23.59 13.09 41 53206 57265 29841966
Blood pressure diastolic abnormal 23.51 13.09 19 53228 1268 29897963
Haematuria 23.50 13.09 27 53220 44807 29854424
Iris coloboma 23.48 13.09 6 53241 19 29899212
Encephalitis Japanese B 23.48 13.09 6 53241 19 29899212
Retinal coloboma 23.24 13.09 6 53241 20 29899211
Product quality issue 23.16 13.09 3 53244 18771 29880460
Pulmonary toxicity 23.11 13.09 34 53213 4482 29894749
Joint range of motion decreased 22.98 13.09 39 53208 5806 29893425
Hepatic enzyme increased 22.98 13.09 119 53128 33375 29865856
White blood cell count increased 22.92 13.09 22 53225 39651 29859580
Squamous cell carcinoma 22.90 13.09 54 53193 10196 29889035
Peritonitis 22.87 13.09 5 53242 21370 29877861
Oral disorder 22.87 13.09 32 53215 4030 29895201
Flushing 22.75 13.09 12 53235 29480 29869751
Chest pain 22.54 13.09 120 53127 117507 29781724
Maculopathy 22.51 13.09 16 53231 880 29898351
Hypokalaemia 22.45 13.09 34 53213 50158 29849073
Arthrodesis 21.99 13.09 12 53235 411 29898820
Neoplasm progression 21.94 13.09 3 53244 18020 29881211
External ear disorder 21.83 13.09 6 53241 27 29899204
Cerebral haemorrhage 21.75 13.09 16 53231 32871 29866360
Joint ankylosis 21.64 13.09 11 53236 325 29898906
Asthenia 21.54 13.09 271 52976 221019 29678212
Haematemesis 21.21 13.09 10 53237 26193 29873038
Meningitis noninfective 21.20 13.09 5 53242 10 29899221
Muscle spasms 21.12 13.09 53 53194 64785 29834446
Pancytopenia 20.97 13.09 79 53168 84973 29814258
Altered state of consciousness 20.63 13.09 5 53242 19914 29879317
Mycobacterium fortuitum infection 20.23 13.09 9 53238 196 29899035
Incorrect dose administered 20.21 13.09 16 53231 31670 29867561
Victim of child abuse 20.17 13.09 10 53237 280 29898951
Dysarthria 19.95 13.09 15 53232 30475 29868756
Shoulder operation 19.91 13.09 14 53233 757 29898474
Antinuclear antibody positive 19.76 13.09 18 53229 1414 29897817
Hepatic failure 19.52 13.09 19 53228 34024 29865207
Subdural haematoma 19.19 13.09 5 53242 18967 29880264
Oral pustule 19.05 13.09 9 53238 226 29899005
Vision blurred 19.02 13.09 28 53219 41788 29857443
Tuberculin test positive 18.89 13.09 15 53232 976 29898255
Hyponatraemia 18.88 13.09 59 53188 67143 29832088
Hepatic cirrhosis 18.86 13.09 67 53180 15932 29883299
Atrial fibrillation 18.72 13.09 114 53133 108010 29791221
Osteonecrosis of jaw 18.66 13.09 5 53242 18613 29880618
Neutrophil Pelger-Huet anomaly present 18.59 13.09 9 53238 239 29898992
Neonatal lupus erythematosus 18.57 13.09 4 53243 4 29899227
Scleroderma renal crisis 18.56 13.09 7 53240 98 29899133
Red blood cell count decreased 18.47 13.09 12 53235 26309 29872922
Lupus pneumonitis 18.39 13.09 6 53241 53 29899178
Depressed level of consciousness 17.97 13.09 25 53222 38197 29861034
Cardiac failure congestive 17.95 13.09 83 53164 84324 29814907
Speech sound disorder 17.91 13.09 6 53241 58 29899173
Haematocrit decreased 17.76 13.09 17 53230 30682 29868549
Intestinal obstruction 17.73 13.09 6 53241 19206 29880025
Abdominal distension 17.66 13.09 34 53213 45675 29853556
Melaena 17.58 13.09 19 53228 32418 29866813
Medium-chain acyl-coenzyme A dehydrogenase deficiency 17.44 13.09 5 53242 27 29899204
Fragile X syndrome 17.29 13.09 5 53242 28 29899203
Suicide attempt 17.25 13.09 24 53223 36673 29862558
Abscess 17.23 13.09 48 53199 10030 29889201
Pneumonia 17.16 13.09 458 52789 333848 29565383
Myalgia 17.13 13.09 74 53173 76593 29822638
Restrictive cardiomyopathy 17.11 13.09 9 53238 286 29898945
Stevens-Johnson syndrome 17.06 13.09 5 53242 17551 29881680
Medication error 16.98 13.09 8 53239 20964 29878267
Blood potassium increased 16.93 13.09 4 53243 16209 29883022
Palmar-plantar erythrodysaesthesia syndrome 16.91 13.09 3 53244 14867 29884364
Wheezing 16.91 13.09 18 53229 30920 29868311
PaO2/FiO2 ratio decreased 16.86 13.09 5 53242 31 29899200
Unevaluable event 16.81 13.09 19 53228 31766 29867465
Acute myocardial infarction 16.68 13.09 44 53203 52895 29846336
Interstitial lung disease 16.67 13.09 172 53075 60025 29839206
Acute cutaneous lupus erythematosus 16.67 13.09 6 53241 73 29899158
Myopathy toxic 16.61 13.09 10 53237 414 29898817
Jaundice 16.56 13.09 20 53227 32466 29866765
Ankle deformity 16.47 13.09 8 53239 214 29899017
Viral vasculitis 16.45 13.09 6 53241 76 29899155
Glucose-6-phosphate dehydrogenase deficiency 16.42 13.09 7 53240 137 29899094
Psychotic disorder 16.23 13.09 9 53238 21506 29877725
Full blood count decreased 16.17 13.09 4 53243 15713 29883518
Renal phospholipidosis 16.00 13.09 3 53244 0 29899231
Facial neuralgia 15.98 13.09 5 53242 38 29899193
Haemoglobin decreased 15.96 13.09 128 53119 113970 29785261
Stent placement 15.91 13.09 29 53218 4567 29894664
Acute pulmonary histoplasmosis 15.91 13.09 6 53241 84 29899147
Coronary artery disease 15.91 13.09 41 53206 49671 29849560
Andersen-Tawil syndrome 15.81 13.09 4 53243 12 29899219
Therapeutic product effect delayed 15.42 13.09 14 53233 1095 29898136
Anomalous pulmonary venous connection 15.35 13.09 6 53241 93 29899138
Shock 15.27 13.09 11 53236 22848 29876383
Symptom recurrence 15.26 13.09 7 53240 164 29899067
Cryopyrin associated periodic syndrome 15.24 13.09 5 53242 45 29899186
Joint effusion 15.15 13.09 25 53222 3638 29895593
Retro-orbital neoplasm 15.13 13.09 4 53243 15 29899216
Pulmonary haemosiderosis 15.13 13.09 4 53243 15 29899216
Aortic bruit 15.07 13.09 7 53240 169 29899062
Urinary retention 15.01 13.09 22 53225 32895 29866336
Fracture 14.92 13.09 33 53214 5973 29893258
Oedema 14.91 13.09 34 53213 42959 29856272
Trisomy 8 14.86 13.09 5 53242 49 29899182
Disseminated strongyloidiasis 14.86 13.09 5 53242 49 29899182
Mental status changes 14.83 13.09 27 53220 37052 29862179
IVth nerve paralysis 14.77 13.09 5 53242 50 29899181
Haemorrhage 14.75 13.09 38 53209 46041 29853190
Retinopathy 14.68 13.09 18 53229 1992 29897239
Hypocalcaemia 14.66 13.09 10 53237 21366 29877865
Erectile dysfunction 14.51 13.09 7 53240 18095 29881136
Emotional distress 14.41 13.09 5 53242 15760 29883471
C-reactive protein 14.33 13.09 6 53241 112 29899119
Hepatitis C 14.31 13.09 3 53244 13202 29886029
Brachycephaly 14.26 13.09 5 53242 56 29899175
Encephalopathy 14.22 13.09 22 53225 32183 29867048
Urticaria 14.17 13.09 154 53093 54452 29844779
Product use issue 13.96 13.09 134 53113 45882 29853349
Histoplasmosis 13.84 13.09 14 53233 1252 29897979
Varicella zoster virus infection 13.82 13.09 14 53233 1254 29897977
Fibromyalgia 13.82 13.09 20 53227 2598 29896633
Neutrophil count increased 13.77 13.09 5 53242 15318 29883913
Multiple organ dysfunction syndrome 13.75 13.09 62 53185 63425 29835806
Osteomyelitis bacterial 13.74 13.09 8 53239 311 29898920
Elbow operation 13.60 13.09 6 53241 128 29899103
Olfactory nerve disorder 13.60 13.09 4 53243 24 29899207
Seborrhoeic dermatitis 13.60 13.09 14 53233 1279 29897952
Child abuse 13.55 13.09 7 53240 214 29899017
Lupus myocarditis 13.46 13.09 4 53243 25 29899206
Anaphylactic reaction 13.46 13.09 18 53229 27964 29871267
Cutaneous lupus erythematosus 13.45 13.09 10 53237 590 29898641
Gout 13.42 13.09 7 53240 17308 29881923
Blood creatine phosphokinase increased 13.40 13.09 37 53210 43811 29855420
Latent tuberculosis 13.39 13.09 12 53235 923 29898308
Depression 13.33 13.09 100 53147 90337 29808894
Wrist deformity 13.23 13.09 8 53239 334 29898897
Cellulitis 13.19 13.09 41 53206 46743 29852488
Disease recurrence 13.17 13.09 55 53192 14106 29885125
Disseminated intravascular coagulation 13.15 13.09 12 53235 22159 29877072
Herpes dermatitis 13.13 13.09 5 53242 72 29899159
Atheroembolism 13.12 13.09 7 53240 229 29899002
Heart rate increased 13.12 13.09 31 53216 38690 29860541

Pharmacologic Action:

SourceCodeDescription
ATC P01BA02 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
ANTIMALARIALS
Aminoquinolines
FDA EPC N0000175482 Antimalarial
FDA EPC N0000175713 Antirheumatic Agent
CHEBI has role CHEBI:35842 antirheumatic agent
CHEBI has role CHEBI:38068 antimalarials
CHEBI has role CHEBI:50177 dermatological agent
CHEBI has role CHEBI:149553 anti-coronaviral agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000962 Antimalarials
MeSH PA D000977 Antiparasitic Agents
MeSH PA D000981 Antiprotozoal Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D004791 Enzyme Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Ovale malaria indication 19341001 DOID:12919
Vivax malaria indication 27052006 DOID:12978
Quartan malaria indication 27618009 DOID:14324
Systemic lupus erythematosus indication 55464009 DOID:9074
Falciparum malaria indication 62676009 DOID:14067
Rheumatoid arthritis indication 69896004 DOID:7148
Discoid lupus erythematosus indication 200938002
Plasmodium Malariae Malaria Prevention indication
Plasmodium Ovale Malaria Prevention indication
Malaria Prevention indication
Plasmodium Falciparum Malaria Prevention indication
Vasculitis of the skin off-label use 53312001
Porphyria cutanea tarda off-label use 61860000 DOID:3132
Q fever endocarditis off-label use 95890006
Coronavirus infection off-label use 186747009
Polymorphic light eruption off-label use 238525001
Juvenile rheumatoid arthritis off-label use 410795001
Hypercalcemia associated with Sarcoidosis off-label use
Alcoholism contraindication 7200002
Psoriasis contraindication 9014002 DOID:8893
Visual field defect contraindication 12184005
Retinal disorder contraindication 29555009 DOID:5679
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Neutropenic disorder contraindication 303011007 DOID:1227
Disorder of macula of retina contraindication 312999006
Disorder of eye contraindication 371405004 DOID:5614
Visual impairment contraindication 397540003
Porphyria contraindication 418470004

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.51 Basic
pKa2 7.83 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Toll-like receptor 7 Membrane receptor ANTAGONIST IC50 5.56 IUPHAR CHEMBL
Toll-like receptor 9 Membrane receptor ANTAGONIST IC50 7.10 IUPHAR CHEMBL
Alpha-1D adrenergic receptor GPCR Ki 5.63 DRUG MATRIX
Potassium voltage-gated channel subfamily H member 2 Ion channel WOMBAT-PK
Hemoglobin subunit alpha Secreted WOMBAT-PK
Muscarinic acetylcholine receptor M2 GPCR Ki 5.98 DRUG MATRIX
SARS-CoV-2 Virus INHIBITOR EC50 5.35 SCIENTIFIC LITERATURE

External reference:

IDSource
4019780 VUID
N0000147871 NUI
D02114 KEGG_DRUG
747-36-4 SECONDARY_CAS_RN
4018253 VANDF
4019780 VANDF
C0020336 UMLSCUI
CHEBI:5801 CHEBI
CHEMBL1535 ChEMBL_ID
CHEMBL1690 ChEMBL_ID
DB01611 DRUGBANK_ID
D006886 MESH_DESCRIPTOR_UI
7198 IUPHAR_LIGAND_ID
796 INN_ID
4QWG6N8QKH UNII
3652 PUBCHEM_CID
153972 RXNORM
15082 MMSL
1645 MMSL
4852 MMSL
d00817 MMSL
002949 NDDF
004906 NDDF
13502005 SNOMEDCT_US
373540008 SNOMEDCT_US
83490000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0093-2401 TABLET, FILM COATED 200 mg ORAL ANDA 10 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0373 TABLET, FILM COATED 200 mg ORAL ANDA 26 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0591-3041 TABLET, FILM COATED 200 mg ORAL ANDA 16 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8325 TABLET, FILM COATED 200 mg ORAL ANDA 11 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8374 TABLET, FILM COATED 200 mg ORAL ANDA 10 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8401 TABLET 200 mg ORAL ANDA 23 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0781-1407 TABLET, FILM COATED 200 mg ORAL ANDA 14 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0781-5994 TABLET, FILM COATED 200 mg ORAL ANDA 25 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6884 TABLET, FILM COATED 200 mg ORAL ANDA 14 sections
HYDROXYCHLOROQUINE SULFATE HUMAN PRESCRIPTION DRUG LABEL 1 0904-7046 TABLET 200 mg ORAL ANDA 16 sections
Hydroxychloroquine Sulfate Human Prescription Drug Label 1 16571-687 TABLET, FILM COATED 200 mg ORAL ANDA 11 sections
Hydroxychloroquine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16714-110 TABLET, FILM COATED 200 mg ORAL ANDA 12 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16714-753 TABLET, FILM COATED 200 mg ORAL ANDA 14 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16729-485 TABLET 200 mg ORAL ANDA 23 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 42292-011 TABLET, FILM COATED 200 mg ENTERAL ANDA 24 sections
Hydroxychloroquine Sulfate Human Prescription Drug Label 1 42385-927 TABLET, FILM COATED 200 mg ORAL ANDA 11 sections
Hydroxychloroquine Sulfate Human Prescription Drug Label 1 43353-051 TABLET 200 mg ORAL NDA AUTHORIZED GENERIC 24 sections
HYDROXYCHLOROQUINE SULFATE Human Prescription Drug Label 1 43598-721 TABLET 200 mg ORAL ANDA 17 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 50090-2508 TABLET, FILM COATED 200 mg ORAL ANDA 16 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 50090-2508 TABLET, FILM COATED 200 mg ORAL ANDA 16 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 50090-3432 TABLET 200 mg ORAL NDA AUTHORIZED GENERIC 24 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 50090-4659 TABLET, FILM COATED 200 mg ORAL ANDA 20 sections
HYDROXYCHLOROQUINE SULFATE HUMAN PRESCRIPTION DRUG LABEL 1 50090-5388 TABLET 200 mg ORAL ANDA 9 sections
HYDROXYCHLOROQUINE SULFATE HUMAN PRESCRIPTION DRUG LABEL 1 50268-412 TABLET 200 mg ORAL ANDA 15 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 53002-4850 TABLET, FILM COATED 200 mg ORAL ANDA 16 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 53808-1112 TABLET, FILM COATED 200 mg ORAL ANDA 13 sections
Hydroxychloroquine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 55154-2074 TABLET, FILM COATED 200 mg ORAL ANDA 12 sections
HYDROXYCHLOROQUINE SULFATE HUMAN PRESCRIPTION DRUG LABEL 1 57664-761 TABLET 200 mg ORAL ANDA 9 sections
Plaquenil Human Prescription Drug Label 1 59212-562 TABLET 200 mg ORAL NDA 25 sections
HYDROXYCHLOROQUINE SULFATEfilm coated HUMAN PRESCRIPTION DRUG LABEL 1 59746-780 TABLET 200 mg ORAL ANDA 12 sections