hydroxyamfetamine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1394 | 103-86-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Amphetamine metabolite with sympathomimetic effects. It is sometimes called alpha-methyltyramine, which may also refer to the meta isomer, gepefrine.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| July 16, 1969 | FDA | PHARMICS |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| FDA MoA | N0000000122 | Adrenergic Agonists |
| MeSH PA | D009184 | Mydriatics |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D013566 | Sympathomimetics |
| FDA EPC | N0000175883 | Adrenergic Receptor Agonist |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Dilated pupil | indication | 37125009 | |
| Ocular hypertension | contraindication | 4210003 | DOID:9282 |
| Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Conduction disorder of the heart | contraindication | 44808001 | |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Open-angle glaucoma | contraindication | 84494001 | DOID:1067 |
| Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
| Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 10.68 | acidic |
| pKa2 | 9.89 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Trace amine-associated receptor 1 | GPCR | AGONIST | EC50 | 5.53 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
| Beta-secretase 1 | Enzyme | Kd | 3.10 | CHEMBL | |||||
| Trace amine-associated receptor 1 | GPCR | EC50 | 7.30 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4018012 | VUID |
| N0000179438 | NUI |
| D04473 | KEGG_DRUG |
| 306-21-8 | SECONDARY_CAS_RN |
| 4018012 | VANDF |
| 4022170 | VANDF |
| C0030140 | UMLSCUI |
| CHEBI:103855 | CHEBI |
| CHEMBL1546 | ChEMBL_ID |
| CHEMBL1200705 | ChEMBL_ID |
| 3651 | PUBCHEM_CID |
| DB09352 | DRUGBANK_ID |
| 7839 | RXNORM |
| 4851 | MMSL |
| 001823 | NDDF |
| 004734 | NDDF |
| 387062009 | SNOMEDCT_US |
| 387290000 | SNOMEDCT_US |
| 52883001 | SNOMEDCT_US |
| D010136 | MESH_DESCRIPTOR_UI |
| 136 | INN_ID |
| 59IG47SZ0E | UNII |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Paremyd | HUMAN PRESCRIPTION DRUG LABEL | 2 | 17478-704 | SOLUTION | 10 mg | OPHTHALMIC | NDA | 21 sections |
| Paremyd | HUMAN PRESCRIPTION DRUG LABEL | 2 | 17478-704 | SOLUTION | 10 mg | OPHTHALMIC | NDA | 21 sections |