hydroxyamfetamine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1394 103-86-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hydroxyamphetamine hydrobromide
  • hydroxyamfetamine hydrobromide
  • hydroxyamfetamine
  • hydroxyamphetamine
  • oxamphetamine
  • hydroxyamphetamide
  • paredrine
  • hydroxyamphetamin
  • para-Hydroxyamphetamine
  • methyltyramine
Amphetamine metabolite with sympathomimetic effects. It is sometimes called alpha-methyltyramine, which may also refer to the meta isomer, gepefrine.
  • Molecular weight: 151.21
  • Formula: C9H13NO
  • CLOGP: 1.07
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 2
  • TPSA: 46.25
  • ALOGS: -1.68
  • ROTB: 2

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
July 16, 1969 FDA PHARMICS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA MoA N0000000122 Adrenergic Agonists
MeSH PA D009184 Mydriatics
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D013566 Sympathomimetics
FDA EPC N0000175883 Adrenergic Receptor Agonist

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Dilated pupil indication 37125009
Ocular hypertension contraindication 4210003 DOID:9282
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Conduction disorder of the heart contraindication 44808001
Diabetes mellitus contraindication 73211009 DOID:9351
Open-angle glaucoma contraindication 84494001 DOID:1067
Angle-closure glaucoma contraindication 392291006 DOID:13550
Myocardial ischemia contraindication 414795007 DOID:3393




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.68 acidic
pKa2 9.89 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Trace amine-associated receptor 1 GPCR AGONIST EC50 5.53 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Beta-secretase 1 Enzyme Kd 3.10 CHEMBL
Trace amine-associated receptor 1 GPCR EC50 7.30 CHEMBL

External reference:

IDSource
4018012 VUID
N0000179438 NUI
D04473 KEGG_DRUG
306-21-8 SECONDARY_CAS_RN
4018012 VANDF
4022170 VANDF
C0030140 UMLSCUI
CHEBI:103855 CHEBI
CHEMBL1546 ChEMBL_ID
CHEMBL1200705 ChEMBL_ID
3651 PUBCHEM_CID
DB09352 DRUGBANK_ID
7839 RXNORM
4851 MMSL
001823 NDDF
004734 NDDF
387062009 SNOMEDCT_US
387290000 SNOMEDCT_US
52883001 SNOMEDCT_US
D010136 MESH_DESCRIPTOR_UI
136 INN_ID
59IG47SZ0E UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Paremyd HUMAN PRESCRIPTION DRUG LABEL 2 17478-704 SOLUTION 10 mg OPHTHALMIC NDA 21 sections
Paremyd HUMAN PRESCRIPTION DRUG LABEL 2 17478-704 SOLUTION 10 mg OPHTHALMIC NDA 21 sections