hydromorphone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
opioid receptor antagonists/agonists, morphinan derivates 1393 466-99-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hydromorphone
  • dihydromorphinone
  • dihydromorphone
  • dimorphone
  • hydromorphon
  • hydromorphone hydrochloride
  • hydromorphone HCl
An opioid analgesic made from MORPHINE and used mainly as an analgesic. It has a shorter duration of action than morphine.
  • Molecular weight: 285.34
  • Formula: C17H19NO3
  • CLOGP: 0.72
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 49.77
  • ALOGS: -1.81
  • ROTB: 0
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mg O
4 mg P
4 mg R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 10 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 6 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.20 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 42 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 4.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 28 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.86 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.30 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Jan. 11, 1984 FDA PURDUE PHARM PRODS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 512.20 10.14 1466 112500 309221 63065835
Temperature regulation disorder 303.71 10.14 169 113797 5963 63369093
Macular degeneration 270.81 10.14 273 113693 24103 63350953
Food allergy 216.85 10.14 173 113793 11228 63363828
Coeliac disease 191.33 10.14 169 113797 12628 63362428
Constipation 173.36 10.14 831 113135 224112 63150944
Immunodeficiency 159 10.14 189 113777 20065 63354991
Pneumonia viral 152.35 10.14 121 113845 7801 63367255
Drug withdrawal syndrome 148.27 10.14 212 113754 26982 63348074
Alopecia 141.46 10.14 243 113723 337293 63037763
Soft tissue disorder 136.50 10.14 90 113876 4332 63370724
Pneumonia aspiration 131.02 10.14 228 113738 34312 63340744
Somnolence 130.33 10.14 650 113316 178035 63197021
Exostosis 124.53 10.14 157 113809 17705 63357351
Joint dislocation 119.72 10.14 158 113808 18642 63356414
Bursitis 118.34 10.14 227 113739 36814 63338242
Drug dependence 116.41 10.14 179 113787 24304 63350752
Retinitis 115.65 10.14 93 113873 6103 63368953
Hepatic cirrhosis 112.26 10.14 177 113789 24557 63350499
Bone erosion 109.90 10.14 147 113819 17570 63357486
Arthritis 108.54 10.14 454 113512 115467 63259589
Nausea 107.84 10.14 2139 111827 852332 62522724
Rheumatoid arthritis 103.69 10.14 795 113171 253024 63122032
Pemphigus 102.57 10.14 107 113859 183619 63191437
Systemic lupus erythematosus 97.32 10.14 140 113826 208778 63166278
Lower respiratory tract infection 96.47 10.14 59 113907 132248 63242808
Maternal exposure during pregnancy 91.57 10.14 159 113807 219903 63155153
Glossodynia 91.32 10.14 112 113854 178764 63196292
Delirium 86.26 10.14 242 113724 50299 63324757
Vaginal flatulence 84.98 10.14 60 113906 3233 63371823
Therapeutic product effect incomplete 84.20 10.14 445 113521 124611 63250445
Hyperaesthesia 82.98 10.14 93 113873 9265 63365791
Arthropathy 82.75 10.14 187 113779 234605 63140451
Muscle injury 82.73 10.14 10 113956 65335 63309721
Swelling 81.19 10.14 240 113726 275138 63099918
Ankylosing spondylitis 80.98 10.14 97 113869 10377 63364679
Respiratory rate decreased 78.92 10.14 59 113907 3476 63371580
Procedural pain 78.71 10.14 140 113826 21429 63353627
Back pain 77.88 10.14 770 113196 263375 63111681
Folliculitis 75.19 10.14 17 113949 70300 63304756
Irritable bowel syndrome 75.07 10.14 27 113939 82385 63292671
Osteoporosis 74.89 10.14 250 113716 57088 63317968
Hypermobility syndrome 74.11 10.14 34 113932 789 63374267
Unresponsive to stimuli 73.18 10.14 177 113789 33639 63341417
Foot deformity 72.70 10.14 157 113809 27696 63347360
Extremity contracture 70.78 10.14 38 113928 1247 63373809
Blepharospasm 68.13 10.14 68 113898 5928 63369128
Duodenal ulcer perforation 67.70 10.14 36 113930 87173 63287883
Overdose 66.49 10.14 393 113573 114685 63260371
Rash erythematous 66.21 10.14 197 113769 42313 63332743
Respiratory depression 64.81 10.14 100 113866 13615 63361441
Vomiting 64.68 10.14 1384 112582 558233 62816823
Laryngitis 64.33 10.14 112 113854 16855 63358201
Proctitis 64.22 10.14 63 113903 5378 63369678
Hyperhidrosis 64.07 10.14 371 113595 107465 63267591
Drug interaction 63.74 10.14 205 113761 228926 63146130
Sleep disorder due to general medical condition, insomnia type 63.68 10.14 9 113957 52208 63322848
Lupus-like syndrome 61.99 10.14 104 113862 15191 63359865
Abdominal discomfort 61.90 10.14 331 113635 320554 63054502
Oral pain 61.85 10.14 149 113817 28245 63346811
Helicobacter infection 60.15 10.14 47 113919 92738 63282318
Intentional overdose 59.96 10.14 29 113937 74123 63300933
Rash 59.62 10.14 682 113284 560189 62814867
Taste disorder 58.20 10.14 95 113871 13567 63361489
Gastrooesophageal reflux disease 58.09 10.14 331 113635 95308 63279748
Pain 57.92 10.14 1738 112228 738890 62636166
Malignant neoplasm progression 57.16 10.14 295 113671 81826 63293230
Blister 55.61 10.14 92 113874 129722 63245334
Device related thrombosis 54.30 10.14 36 113930 1749 63373307
Sickle cell anaemia with crisis 53.81 10.14 60 113906 5943 63369113
Female genital tract fistula 53.58 10.14 67 113899 7492 63367564
Narcotic bowel syndrome 53.41 10.14 17 113949 136 63374920
Radiculopathy 52.72 10.14 71 113895 8540 63366516
Migraine 52.21 10.14 341 113625 103005 63272051
Inadequate analgesia 50.36 10.14 42 113924 2901 63372155
Coma 50.33 10.14 239 113727 64125 63310931
Fluid retention 49.89 10.14 226 113740 59460 63315596
Medical device site pain 49.71 10.14 17 113949 174 63374882
Product dose omission issue 49.55 10.14 234 113732 234079 63140977
Implant site extravasation 49.32 10.14 22 113944 477 63374579
Joint stiffness 48.96 10.14 176 113790 41693 63333363
Hand deformity 48.39 10.14 137 113829 159320 63215736
Breast cancer metastatic 47.75 10.14 81 113885 11937 63363119
Injection site erythema 46.88 10.14 48 113918 83126 63291930
Neoplasm progression 46.82 10.14 158 113808 36270 63338786
Accidental death 46.40 10.14 34 113932 1942 63373114
Hypoaesthesia 46.26 10.14 484 113482 167909 63207147
Chronic sinusitis 45.12 10.14 82 113884 12761 63362295
Abdominal pain 44.13 10.14 756 113210 292700 63082356
Impaired healing 43.61 10.14 73 113893 102469 63272587
Asthma 43.10 10.14 383 113583 127178 63247878
Herpes zoster 42.81 10.14 274 113692 82188 63292868
Neutropenia 41.72 10.14 167 113799 174838 63200218
Injection site pain 41.26 10.14 109 113857 129691 63245365
Drug diversion 41.22 10.14 24 113942 924 63374132
Cardiac failure congestive 40.05 10.14 65 113901 92368 63282688
Decompression sickness 39.86 10.14 12 113954 78 63374978
Sinusitis 39.77 10.14 241 113725 226412 63148644
Vaginal discharge 39.23 10.14 64 113902 9134 63365922
Drug reaction with eosinophilia and systemic symptoms 38.63 10.14 7 113959 33829 63341227
Pericarditis 38.49 10.14 115 113851 131464 63243592
Abortion spontaneous 37.33 10.14 19 113947 47176 63327880
Myocardial infarction 37.27 10.14 77 113889 99816 63275240
Hereditary angioedema 36.94 10.14 56 113910 7506 63367550
Anti-cyclic citrullinated peptide antibody positive 36.62 10.14 98 113868 116114 63258942
Postmortem blood drug level increased 36.49 10.14 19 113947 585 63374471
Injection site swelling 36.38 10.14 20 113946 47552 63327504
Hyponatraemia 35.54 10.14 94 113872 111806 63263250
Erythema 34.97 10.14 475 113491 175276 63199780
Alveolitis 34.87 10.14 34 113932 2881 63372175
Anaphylactic reaction 34.53 10.14 220 113746 65880 63309176
Rheumatoid factor negative 33.46 10.14 18 113948 593 63374463
Red blood cell sedimentation rate increased 33.42 10.14 162 113804 43820 63331236
Injection site pruritus 33.03 10.14 20 113946 45096 63329960
Hepatitis 33.03 10.14 15 113951 39773 63335283
Small intestinal obstruction 32.46 10.14 89 113877 18248 63356808
Hepatic function abnormal 32.43 10.14 13 113953 37129 63337927
Interstitial lung disease 32.37 10.14 38 113928 61870 63313186
Faecal volume decreased 31.90 10.14 12 113954 165 63374891
Secondary amyloidosis 31.79 10.14 11 113955 117 63374939
Foetal exposure during pregnancy 31.71 10.14 9 113957 31953 63343103
Plasma cell myeloma 31.54 10.14 138 113828 35767 63339289
Pregnancy 30.40 10.14 14 113952 36822 63338234
Tissue infiltration 30.23 10.14 17 113949 612 63374444
Hypertensive encephalopathy 30.01 10.14 17 113949 621 63374435
Paraesthesia oral 29.75 10.14 89 113877 19167 63355889
Pustular psoriasis 29.64 10.14 39 113927 4587 63370469
Mental status changes 29.48 10.14 145 113821 39454 63335602
Overwork 29.44 10.14 9 113957 62 63374994
Tenderness 29.07 10.14 98 113868 22480 63352576
Acute chest syndrome 28.52 10.14 18 113948 803 63374253
Weight decreased 28.51 10.14 674 113292 276124 63098932
Labelled drug-drug interaction issue 28.27 10.14 20 113946 1081 63373975
Orthostatic hypotension 27.95 10.14 15 113951 36145 63338911
Intentional self-injury 27.88 10.14 6 113960 25681 63349375
Head banging 27.78 10.14 14 113952 402 63374654
Obstruction 27.59 10.14 31 113935 3096 63371960
Scar 27.56 10.14 70 113896 13712 63361344
Rhesus antigen positive 27.52 10.14 10 113956 124 63374932
Blood pressure systolic increased 27.44 10.14 162 113804 47235 63327821
Platelet aggregation inhibition 26.95 10.14 10 113956 132 63374924
COVID-19 26.90 10.14 108 113858 112995 63262061
Drug eruption 26.82 10.14 9 113957 28685 63346371
Basal ganglion degeneration 26.80 10.14 14 113952 434 63374622
Psoriatic arthropathy 26.75 10.14 80 113886 91440 63283616
Visual impairment 26.71 10.14 250 113716 84196 63290860
Drug ineffective for unapproved indication 26.27 10.14 126 113840 33937 63341119
Compartment syndrome 26.13 10.14 26 113940 2258 63372798
Acute kidney injury 26.08 10.14 325 113641 263090 63111966
Rash pruritic 25.95 10.14 42 113924 59757 63315299
Biliary tract infection 25.92 10.14 16 113950 686 63374370
Pruritus 25.83 10.14 475 113491 360978 63014078
Opiates positive 25.81 10.14 13 113953 373 63374683
Toxicologic test abnormal 25.53 10.14 16 113950 705 63374351
Upper respiratory tract infection 25.50 10.14 242 113724 81805 63293251
Bacillus infection 25.45 10.14 17 113949 836 63374220
Clostridium test positive 25.33 10.14 30 113936 3171 63371885
Osteoarthritis 24.74 10.14 271 113695 95072 63279984
Bursitis infective 24.73 10.14 20 113946 1323 63373733
Malaise 24.69 10.14 946 113020 415008 62960048
Cholestasis 24.58 10.14 11 113955 29423 63345633
Oral candidiasis 24.28 10.14 93 113873 22705 63352351
Balance disorder 23.82 10.14 75 113891 84347 63290709
Post procedural complication 23.68 10.14 76 113890 16998 63358058
Pulmonary fibrosis 23.55 10.14 22 113944 39787 63335269
Ill-defined disorder 23.51 10.14 72 113894 81683 63293373
Blood pressure fluctuation 23.48 10.14 153 113813 46164 63328892
Immunoglobulins decreased 23.28 10.14 19 113947 1273 63373783
Dyspnoea 23.27 10.14 961 113005 660352 62714704
Screaming 23.26 10.14 29 113937 3233 63371823
Hepatocellular injury 23.23 10.14 10 113956 27371 63347685
No adverse event 23.21 10.14 24 113942 41381 63333675
Pancreatitis 23.04 10.14 159 113807 48896 63326160
Frequent bowel movements 22.97 10.14 92 113874 22930 63352126
Myelosuppression 22.92 10.14 7 113959 23696 63351360
Alanine aminotransferase increased 22.88 10.14 102 113864 103668 63271388
Red blood cell sedimentation rate abnormal 22.78 10.14 4 113962 19778 63355278
Suicide attempt 22.68 10.14 47 113919 60871 63314185
Drug abuse 22.59 10.14 214 113752 72304 63302752
Lactobacillus infection 22.56 10.14 7 113959 51 63375005
Drug ineffective 22.55 10.14 2171 111795 1042594 62332462
Drug intolerance 22.54 10.14 719 113247 307942 63067114
Bronchomalacia 22.20 10.14 10 113956 222 63374834
Premature baby 22.19 10.14 5 113961 20730 63354326
Intestinal obstruction 22.19 10.14 112 113854 30787 63344269
Bradycardia 22.13 10.14 63 113903 73164 63301892
Monoplegia 22.09 10.14 28 113938 3173 63371883
Colitis ulcerative 21.95 10.14 99 113867 25992 63349064
White blood cell count decreased 21.80 10.14 153 113813 138951 63236105
Ear infection 21.72 10.14 130 113836 38083 63336973
Lactic acidosis 21.68 10.14 22 113944 38265 63336791
Dry eye 21.33 10.14 25 113941 40736 63334320
Cardiac failure 21.27 10.14 85 113881 89057 63285999
Exposure during pregnancy 21.13 10.14 178 113788 155369 63219687
Amputation stump pain 21.09 10.14 6 113960 31 63375025
Injection site reaction 21.08 10.14 46 113920 58478 63316578
Cryopyrin associated periodic syndrome 20.83 10.14 11 113955 349 63374707
Withdrawal syndrome 20.83 10.14 81 113885 19916 63355140
Rheumatoid nodule 20.81 10.14 3 113963 17152 63357904
Malignant polyp 20.75 10.14 9 113957 182 63374874
Apnoea 20.68 10.14 45 113921 7977 63367079
Cholangitis infective 20.66 10.14 11 113955 355 63374701
Cytomegalovirus infection 20.60 10.14 6 113960 20946 63354110
Product name confusion 20.18 10.14 7 113959 75 63374981
Metastases to bone 20.18 10.14 83 113883 20936 63354120
Wound 19.91 10.14 192 113774 163071 63211985
Gastrointestinal disorder 19.76 10.14 146 113820 131093 63243963
Colitis 19.75 10.14 152 113814 48376 63326680
Radiation necrosis 19.64 10.14 11 113955 393 63374663
Ligament pain 19.57 10.14 9 113957 210 63374846
Tumour pain 19.55 10.14 18 113948 1419 63373637
Groin pain 19.55 10.14 51 113915 10152 63364904
Red cell distribution width increased 19.55 10.14 52 113914 10472 63364584
Cystitis 19.54 10.14 167 113799 54824 63320232
Treatment failure 19.53 10.14 246 113720 198797 63176259
Syncope 19.44 10.14 127 113839 117258 63257798
Renal impairment 19.38 10.14 87 113879 88268 63286788
Pulmonary congestion 19.33 10.14 72 113894 17346 63357710
Multiple sclerosis relapse 19.26 10.14 36 113930 48442 63326614
Rheumatic fever 18.97 10.14 30 113936 43081 63331975
Poor venous access 18.88 10.14 64 113902 14721 63360335
Anaesthesia 18.88 10.14 11 113955 424 63374632
Limb mass 18.80 10.14 26 113940 3206 63371850
Urticaria thermal 18.79 10.14 11 113955 428 63374628
Eye irritation 18.68 10.14 8 113958 21963 63353093
Incorrect route of product administration 18.66 10.14 98 113868 27354 63347702
Mental disorder 18.65 10.14 94 113872 25825 63349231
Extradural haematoma 18.60 10.14 19 113947 1703 63373353
Accidental overdose 18.54 10.14 87 113879 23222 63351834
Foreign body embolism 18.53 10.14 4 113962 4 63375052
Caesarean section 18.44 10.14 4 113962 17028 63358028
Hypocalcaemia 18.21 10.14 18 113948 31695 63343361
Live birth 17.89 10.14 12 113954 25618 63349438
Inappropriate schedule of product administration 17.88 10.14 274 113692 103691 63271365
Spinal cord compression 17.88 10.14 29 113937 4119 63370937
Multiple organ dysfunction syndrome 17.76 10.14 48 113918 56704 63318352
Sedation 17.76 10.14 125 113841 38684 63336372
Status epilepticus 17.72 10.14 3 113963 15230 63359826
Palpitations 17.68 10.14 124 113842 112646 63262410
Cholangitis sclerosing 17.53 10.14 18 113948 1623 63373433
Uterine enlargement 17.48 10.14 16 113950 1252 63373804
Virologic failure 17.36 10.14 19 113947 1843 63373213
Ocular procedural complication 17.22 10.14 10 113956 383 63374673
Hepatotoxicity 17.04 10.14 25 113941 37016 63338040
Substance dependence 17.04 10.14 8 113958 196 63374860
Iodine allergy 17.02 10.14 13 113953 791 63374265
Localised infection 16.68 10.14 102 113864 30108 63344948
Respiratory syncytial virus infection 16.56 10.14 38 113928 6980 63368076
Adiposis dolorosa 16.53 10.14 9 113957 304 63374752
Antidepressant drug level above therapeutic 16.24 10.14 10 113956 427 63374629
Iritis 16.21 10.14 24 113942 3151 63371905
Vitamin K deficiency 16.18 10.14 10 113956 430 63374626
Sopor 15.98 10.14 10 113956 22154 63352902
Miliaria 15.94 10.14 15 113951 1216 63373840
Seasonal allergy 15.74 10.14 9 113957 20941 63354115
Discomfort 15.63 10.14 209 113757 167165 63207891
Toxic leukoencephalopathy 15.58 10.14 12 113954 739 63374317
Treatment noncompliance 15.47 10.14 27 113939 37298 63337758
Knee arthroplasty 15.40 10.14 48 113918 54158 63320898
Renal cyst 15.34 10.14 47 113919 10255 63364801
Heart rate increased 15.31 10.14 246 113720 93992 63281064
Occipital neuralgia 15.28 10.14 10 113956 475 63374581
Mucosal inflammation 15.21 10.14 39 113927 46889 63328167
Spinal pain 15.16 10.14 55 113911 13084 63361972
Urticaria 15.13 10.14 208 113758 165594 63209462
Therapeutic product effect decreased 15.01 10.14 250 113716 192937 63182119
Blood pressure increased 14.98 10.14 389 113577 161673 63213383
Dental caries 14.96 10.14 48 113918 10731 63364325
Scratch 14.89 10.14 35 113931 6530 63368526
Grip strength decreased 14.81 10.14 11 113955 22276 63352780
Blood immunoglobulin M decreased 14.67 10.14 13 113953 975 63374081
Pneumocystis jirovecii pneumonia 14.64 10.14 6 113960 16908 63358148
Drug tolerance 14.63 10.14 36 113930 6913 63368143
Ischaemic stroke 14.55 10.14 7 113959 17950 63357106
Melaena 14.46 10.14 20 113946 30345 63344711
Food aversion 14.45 10.14 12 113954 824 63374232
Vulvovaginal inflammation 14.41 10.14 12 113954 827 63374229
Premature delivery 14.37 10.14 20 113946 30261 63344795
Lip dry 14.20 10.14 5 113961 15465 63359591
Conjunctivitis 14.16 10.14 10 113956 20786 63354270
Photophobia 14.15 10.14 66 113900 17569 63357487
Progressive multifocal leukoencephalopathy 14.14 10.14 3 113963 12968 63362088
Swollen joint count increased 14.12 10.14 27 113939 36027 63339029
Dyspnoea exertional 14.07 10.14 58 113908 60244 63314812
Clostridium difficile infection 14.06 10.14 97 113869 29825 63345231
Obstructive airways disorder 14.03 10.14 10 113956 20689 63354367
Hyperkalaemia 14.02 10.14 50 113916 54153 63320903
Neuralgia 13.98 10.14 87 113879 25839 63349217
Silicon granuloma 13.90 10.14 3 113963 3 63375053
Heart rate irregular 13.86 10.14 78 113888 22343 63352713
Gastrointestinal haemorrhage 13.86 10.14 87 113879 81089 63293967
C-reactive protein increased 13.84 10.14 243 113723 94464 63280592
Abdominal tenderness 13.82 10.14 39 113927 8127 63366929
Aptyalism 13.82 10.14 10 113956 560 63374496
Injection site warmth 13.80 10.14 5 113961 15190 63359866
Basal cell carcinoma 13.77 10.14 18 113948 27973 63347083
Respiratory failure 13.71 10.14 258 113708 101600 63273456
Skin necrosis 13.71 10.14 4 113962 13946 63361110
Respiratory arrest 13.70 10.14 103 113863 32542 63342514
Eye operation 13.68 10.14 19 113947 2353 63372703
Agranulocytosis 13.60 10.14 15 113951 25119 63349937
Foetal death 13.56 10.14 47 113919 10933 63364123
Metabolic acidosis 13.45 10.14 39 113927 45030 63330026
Blood triglycerides increased 13.39 10.14 3 113963 12485 63362571
Stevens-Johnson syndrome 13.38 10.14 15 113951 24935 63350121
General physical health deterioration 13.36 10.14 464 113502 200938 63174118
Transient ischaemic attack 13.33 10.14 30 113936 37723 63337333
Fistula 13.28 10.14 45 113921 10348 63364708
Diarrhoea 13.26 10.14 1105 112861 714261 62660795
Toe amputation 13.25 10.14 17 113949 1950 63373106
Cerebral infarction 13.22 10.14 14 113952 23879 63351177
Hypothermia 13.15 10.14 4 113962 13577 63361479
Psychiatric symptom 13.12 10.14 29 113937 5194 63369862
Tubulointerstitial nephritis 13.00 10.14 10 113956 19893 63355163
Oxygen saturation abnormal 12.99 10.14 23 113943 3506 63371550
Visual acuity reduced 12.98 10.14 12 113954 21814 63353242
Bowel movement irregularity 12.97 10.14 29 113937 5235 63369821
Hip arthroplasty 12.97 10.14 43 113923 47603 63327453
Haematochezia 12.89 10.14 150 113816 53394 63321662
Aspartate aminotransferase increased 12.85 10.14 102 113864 90175 63284881
Infection 12.81 10.14 518 113448 228655 63146401
Implant site haematoma 12.78 10.14 5 113961 77 63374979
Synovitis 12.74 10.14 432 113534 186486 63188570
Wrong technique in product usage process 12.72 10.14 63 113903 62277 63312779
Eye pruritus 12.69 10.14 9 113957 18662 63356394
Left ventricular dilatation 12.63 10.14 9 113957 492 63374564
Allodynia 12.61 10.14 11 113955 808 63374248
Infusion site mass 12.58 10.14 17 113949 2051 63373005
Ocular hyperaemia 12.55 10.14 16 113950 25128 63349928
Postoperative ileus 12.49 10.14 9 113957 501 63374555
Intervertebral disc protrusion 12.43 10.14 79 113887 23630 63351426
Substance abuse 12.43 10.14 27 113939 4780 63370276
Contusion 12.38 10.14 192 113774 149852 63225204
Carbohydrate antigen 19-9 increased 12.35 10.14 7 113959 256 63374800
Mucous stools 12.31 10.14 25 113941 4223 63370833
Weight increased 12.10 10.14 366 113600 260426 63114630
Eastern Cooperative Oncology Group performance status worsened 12.05 10.14 13 113953 1241 63373815
Tachyphylaxis 12.03 10.14 7 113959 269 63374787
Coronary artery disease 12.03 10.14 25 113941 32352 63342704
Intracranial pressure increased 12.00 10.14 28 113938 5199 63369857
Psychogenic seizure 11.99 10.14 15 113951 1677 63373379
Rubella 11.95 10.14 6 113960 171 63374885
Product storage error 11.86 10.14 6 113960 14950 63360106
Product substitution issue 11.84 10.14 7 113959 15989 63359067
Foreign body reaction 11.77 10.14 5 113961 96 63374960
Complement factor C4 decreased 11.71 10.14 7 113959 283 63374773
Perineal pain 11.67 10.14 7 113959 285 63374771
Confusional state 11.65 10.14 329 113637 236051 63139005
Anuria 11.62 10.14 4 113962 12547 63362509
Liver function test abnormal 11.61 10.14 135 113831 48046 63327010
Presyncope 11.60 10.14 20 113946 27765 63347291
Intestinal pseudo-obstruction 11.59 10.14 11 113955 901 63374155
Apnoeic attack 11.56 10.14 7 113959 290 63374766
Administration site bruise 11.55 10.14 8 113958 418 63374638
Complement factor C3 decreased 11.54 10.14 7 113959 291 63374765
Secretion discharge 11.50 10.14 48 113918 12183 63362873
Lower respiratory tract infection viral 11.50 10.14 11 113955 910 63374146
Skin laceration 11.50 10.14 75 113891 22633 63352423
Nervousness 11.49 10.14 95 113871 30884 63344172
Inguinal hernia 11.46 10.14 16 113950 1991 63373065
Diaphragmatic hernia 11.45 10.14 8 113958 424 63374632
Choroid melanoma 11.44 10.14 4 113962 44 63375012
Mitral valve incompetence 11.39 10.14 11 113955 19583 63355473
Central nervous system infection 11.33 10.14 10 113956 746 63374310
Intestinal perforation 11.29 10.14 47 113919 11916 63363140
Therapy interrupted 11.29 10.14 26 113940 32429 63342627
Administration site erythema 11.23 10.14 10 113956 755 63374301
Hypoxia 11.23 10.14 160 113806 59632 63315424
Psychotic disorder 11.21 10.14 18 113948 25694 63349362
Condition aggravated 11.20 10.14 599 113367 401618 62973438
Umbilical discharge 11.19 10.14 5 113961 109 63374947
Bacteraemia 11.16 10.14 61 113905 17287 63357769
Respiratory tract inflammation 11.13 10.14 9 113957 595 63374461
Rib fracture 11.06 10.14 74 113892 22523 63352533
Wound infection bacterial 11.00 10.14 9 113957 605 63374451
Breast cancer 11.00 10.14 47 113919 48336 63326720
Pseudostroke 10.98 10.14 4 113962 50 63375006
Respiratory rate increased 10.90 10.14 51 113915 13597 63361459
Complex regional pain syndrome 10.88 10.14 17 113949 2340 63372716
Diaphragmatic paralysis 10.88 10.14 9 113957 615 63374441
Klebsiella infection 10.87 10.14 37 113929 8529 63366527
Death 10.86 10.14 796 113170 373585 63001471
Cerebrospinal fluid leakage 10.85 10.14 12 113954 1178 63373878
Liver injury 10.78 10.14 64 113902 60456 63314600
Rectal haemorrhage 10.78 10.14 135 113831 48895 63326161
Stomatococcal infection 10.74 10.14 5 113961 120 63374936
Rash maculo-papular 10.73 10.14 26 113940 31870 63343186
Gastric infection 10.68 10.14 21 113945 3466 63371590
Coccygectomy 10.63 10.14 3 113963 15 63375041
Implant site infection 10.61 10.14 11 113955 1003 63374053
Emotional distress 10.61 10.14 97 113869 32452 63342604
Abdominal hernia 10.59 10.14 26 113940 4986 63370070
Bone pain 10.57 10.14 147 113819 54494 63320562
Irregular breathing 10.54 10.14 7 113959 341 63374715
Device failure 10.46 10.14 29 113937 5982 63369074
Liver iron concentration abnormal 10.44 10.14 4 113962 58 63374998
Implant site pain 10.44 10.14 17 113949 2423 63372633
Soft tissue swelling 10.41 10.14 12 113954 1232 63373824
Weight fluctuation 10.41 10.14 40 113926 9779 63365277
Brain injury 10.36 10.14 32 113934 7011 63368045
Pain in extremity 10.33 10.14 709 113257 330777 63044279
Rectal fissure 10.32 10.14 9 113957 661 63374395
Ileus 10.31 10.14 53 113913 14672 63360384
Eyelid oedema 10.30 10.14 3 113963 10476 63364580
Pouchitis 10.30 10.14 8 113958 499 63374557
Breast conserving surgery 10.30 10.14 11 113955 1038 63374018
Escherichia bacteraemia 10.26 10.14 22 113944 3861 63371195
Monoclonal gammopathy 10.21 10.14 9 113957 670 63374386
Encephalitis brain stem 10.20 10.14 5 113961 135 63374921
Blood calcium decreased 10.19 10.14 20 113946 26431 63348625
Pulmonary embolism 10.18 10.14 278 113688 116406 63258650
Food intolerance 10.15 10.14 20 113946 3305 63371751

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug dependence 243.23 11.34 247 57440 23970 34875274
Appendicolith 218.03 11.34 150 57537 8451 34890793
Nausea 165.02 11.34 1040 56647 338868 34560376
Sedation 163.03 11.34 187 57500 20819 34878425
Appendicitis 161.51 11.34 158 57529 14649 34884595
Stress 145.67 11.34 213 57474 30134 34869110
Hyperaesthesia 144.63 11.34 92 57595 4538 34894706
Drug withdrawal syndrome 136.42 11.34 166 57521 19668 34879576
Constipation 135.00 11.34 514 57173 136468 34762776
Pain 124.88 11.34 666 57021 204009 34695235
Respiratory depression 110.15 11.34 135 57552 16110 34883134
Cardiogenic shock 106.85 11.34 172 57515 26446 34872798
Vomiting 104.28 11.34 732 56955 246889 34652355
Abdominal pain 97.37 11.34 529 57158 163089 34736155
Abdominal distension 94.39 11.34 260 57427 58232 34841012
Blood phosphorus increased 89.10 11.34 85 57602 7636 34891608
General physical health deterioration 81.92 11.34 423 57264 127846 34771398
Ascites 73.12 11.34 205 57482 46366 34852878
Victim of child abuse 66.84 11.34 32 57655 895 34898349
Toxicologic test abnormal 65.24 11.34 27 57660 529 34898715
Postmortem blood drug level abnormal 58.13 11.34 21 57666 280 34898964
Somnolence 56.65 11.34 345 57342 110771 34788473
Drug tolerance 56.45 11.34 43 57644 2839 34896405
Ventricular fibrillation 56.31 11.34 120 57567 22834 34876410
Hyponatraemia 55.75 11.34 277 57410 82414 34816830
Epidural lipomatosis 51.55 11.34 28 57659 1026 34898218
Inadequate analgesia 48.83 11.34 40 57647 2935 34896309
Product used for unknown indication 47.76 11.34 26 57661 957 34898287
Drug interaction 47.30 11.34 202 57485 225744 34673500
Medical device site pain 46.80 11.34 13 57674 67 34899177
Nightmare 45.90 11.34 84 57603 14307 34884937
Chest injury 45.71 11.34 30 57657 1561 34897683
Drug hypersensitivity 44.87 11.34 256 57431 80273 34818971
Back pain 44.77 11.34 349 57338 121440 34777804
Hyperhidrosis 44.41 11.34 244 57443 75448 34823796
Cardiac failure 41.28 11.34 54 57633 91194 34808050
Child abuse 41.04 11.34 18 57669 409 34898835
Interstitial lung disease 40.73 11.34 29 57658 65253 34833991
Product prescribing error 40.05 11.34 105 57582 22822 34876422
Painful respiration 39.70 11.34 25 57662 1211 34898033
Unresponsive to stimuli 39.05 11.34 117 57570 27452 34871792
Myoclonus 38.47 11.34 79 57608 14646 34884598
Neuralgia 38.21 11.34 80 57607 15033 34884211
Systemic infection 38.08 11.34 45 57642 5167 34894077
Arachnoiditis 36.70 11.34 16 57671 358 34898886
Myocardial infarction 36.56 11.34 92 57595 120993 34778251
Device power source issue 36.54 11.34 16 57671 362 34898882
Juvenile idiopathic arthritis 36.48 11.34 28 57659 1869 34897375
Serotonin syndrome 35.55 11.34 92 57595 19841 34879403
Product dose omission issue 35.34 11.34 92 57595 119619 34779625
Respiratory rate decreased 35.16 11.34 30 57657 2329 34896915
Apnoeic attack 34.71 11.34 16 57671 410 34898834
Acute kidney injury 34.70 11.34 329 57358 304659 34594585
Prostate cancer metastatic 34.22 11.34 45 57642 5758 34893486
Nephrolithiasis 34.15 11.34 119 57568 30214 34869030
Postoperative ileus 32.40 11.34 18 57669 690 34898554
Confusional state 32.36 11.34 372 57315 143788 34755456
Pelvic pain 31.88 11.34 29 57658 2451 34896793
Walking aid user 31.85 11.34 26 57661 1898 34897346
Plasma cell myeloma 31.32 11.34 145 57542 41892 34857352
Delirium 30.78 11.34 149 57538 43842 34855402
Xyphoid retraction 29.45 11.34 11 57676 162 34899082
Cardiac failure congestive 29.44 11.34 58 57629 83212 34816032
Rhabdomyolysis 29.15 11.34 42 57645 68121 34831123
Renal failure 28.98 11.34 114 57573 130443 34768801
Substance abuse 28.79 11.34 48 57639 7593 34891651
Hepatic function abnormal 28.61 11.34 19 57668 44344 34854900
Withdrawal syndrome 28.14 11.34 63 57624 12392 34886852
Mental status changes 28.11 11.34 131 57556 37952 34861292
Drug abuse 28.01 11.34 268 57419 98828 34800416
Drug tolerance increased 27.11 11.34 14 57673 462 34898782
Terminal insomnia 27.04 11.34 15 57672 573 34898671
Neutropenia 25.98 11.34 152 57535 156626 34742618
Dry mouth 25.46 11.34 108 57579 30057 34869187
Renal impairment 25.39 11.34 76 57611 94437 34804807
Anaesthetic complication neurological 25.35 11.34 12 57675 327 34898917
Myasthenia gravis 25.35 11.34 43 57644 6897 34892347
Febrile neutropenia 25.06 11.34 340 57347 136509 34762735
Syncope 24.95 11.34 73 57614 91378 34807866
Opiates positive 24.50 11.34 14 57673 567 34898677
Anaemia of malignant disease 24.32 11.34 13 57674 461 34898783
Blood creatine phosphokinase increased 24.16 11.34 23 57664 44834 34854410
Substance dependence 23.96 11.34 12 57675 371 34898873
Sepsis 23.59 11.34 396 57291 166165 34733079
Seizure like phenomena 23.41 11.34 15 57672 749 34898495
Incorrect route of product administration 22.94 11.34 65 57622 14780 34884464
Drug reaction with eosinophilia and systemic symptoms 22.87 11.34 13 57674 32999 34866245
Suicide attempt 22.33 11.34 19 57668 39097 34860147
Drug therapy 22.29 11.34 17 57670 1124 34898120
Electrocardiogram QT prolonged 22.05 11.34 21 57666 40931 34858313
Blood pressure systolic increased 21.60 11.34 85 57602 22867 34876377
Coronary artery disease 21.41 11.34 29 57658 48276 34850968
Cerebral haemorrhage 21.16 11.34 16 57671 34921 34864323
Immune-mediated hepatitis 21.15 11.34 22 57665 2193 34897051
Blood uric acid increased 20.98 11.34 48 57639 9576 34889668
Malignant neoplasm progression 20.54 11.34 229 57458 87817 34811427
Blood pressure diastolic abnormal 20.52 11.34 32 57655 4786 34894458
Respiratory arrest 20.35 11.34 96 57591 27947 34871297
Oesophageal infection 20.27 11.34 10 57677 299 34898945
Sickle cell anaemia with crisis 20.23 11.34 29 57658 4024 34895220
Eosinophilia 20.15 11.34 9 57678 26213 34873031
Death 20.13 11.34 825 56862 397224 34502020
Congenital megaureter 19.65 11.34 8 57679 150 34899094
Neoplasm progression 19.33 11.34 83 57604 23217 34876027
Lymphoedema 19.05 11.34 28 57659 3975 34895269
Atrial fibrillation 19.04 11.34 121 57566 122272 34776972
Neurotoxicity 18.85 11.34 69 57618 17941 34881303
Forced expiratory flow decreased 18.69 11.34 8 57679 171 34899073
Gastrointestinal haemorrhage 18.52 11.34 79 57608 88398 34810846
Sputum discoloured 18.19 11.34 40 57647 7772 34891472
Foreign body embolism 17.98 11.34 4 57683 6 34899238
Microembolism 17.96 11.34 5 57682 26 34899218
Iron deficiency 17.91 11.34 32 57655 5349 34893895
Blood pressure systolic abnormal 17.91 11.34 27 57660 3921 34895323
Hot flush 17.90 11.34 68 57619 17998 34881246
Haemorrhoids thrombosed 17.61 11.34 8 57679 198 34899046
Hypoxia 17.58 11.34 153 57534 54942 34844302
Poor venous access 17.48 11.34 31 57656 5152 34894092
Lethargy 17.45 11.34 122 57565 41000 34858244
Lactic acidosis 17.39 11.34 19 57668 34753 34864491
Oesophageal mucosa erythema 17.36 11.34 5 57682 30 34899214
Sleep disorder therapy 17.31 11.34 14 57673 1009 34898235
Device kink 17.17 11.34 10 57677 420 34898824
Sleep disorder 17.14 11.34 100 57587 31588 34867656
Melaena 16.97 11.34 20 57667 35360 34863884
Metastasis 16.92 11.34 27 57660 4117 34895127
Mucosal atrophy 16.89 11.34 6 57681 76 34899168
Hypoglycaemia 16.88 11.34 41 57646 54599 34844645
Clostridium test positive 16.81 11.34 24 57663 3318 34895926
Intentional overdose 16.69 11.34 29 57658 43645 34855599
Multiple organ dysfunction syndrome 16.45 11.34 196 57491 76370 34822874
Injection related reaction 16.20 11.34 9 57678 345 34898899
Hip surgery 16.18 11.34 14 57673 1108 34898136
Antasthmatic drug level 16.12 11.34 5 57682 40 34899204
Pancreatic carcinoma metastatic 16.11 11.34 22 57665 2918 34896326
Cerebral infarction 16.09 11.34 13 57674 27442 34871802
Angioedema 16.00 11.34 23 57664 37351 34861893
Bradycardia 16.00 11.34 67 57620 75351 34823893
Delirium tremens 15.99 11.34 11 57676 619 34898625
Analgesic drug level 15.81 11.34 5 57682 43 34899201
Cytomegalovirus infection 15.79 11.34 12 57675 26123 34873121
Overdose 15.74 11.34 224 57463 90835 34808409
Spinal shock 15.60 11.34 5 57682 45 34899199
Epilepsy 15.56 11.34 8 57679 21487 34877757
Axillary pain 15.54 11.34 9 57678 374 34898870
Injection site mass 15.51 11.34 34 57653 6592 34892652
Arrhythmia 15.37 11.34 22 57665 35786 34863458
Burkholderia test positive 15.23 11.34 13 57674 1010 34898234
Intentional product use issue 15.07 11.34 158 57529 59658 34839586
Ventricular tachycardia 15.06 11.34 13 57674 26566 34872678
Hepatocellular injury 15.02 11.34 9 57678 22202 34877042
Tendon disorder 14.99 11.34 21 57666 2854 34896390
Postoperative delirium 14.88 11.34 7 57680 188 34899056
Device computer issue 14.85 11.34 4 57683 18 34899226
Type IIa hyperlipidaemia 14.78 11.34 7 57680 191 34899053
Cerebrovascular accident 14.69 11.34 81 57606 84730 34814514
Allergy to metals 14.62 11.34 6 57681 115 34899129
Pathological fracture 14.47 11.34 26 57661 4365 34894879
Decreased appetite 14.42 11.34 368 57319 166024 34733220
Hepatitis 14.41 11.34 11 57676 23893 34875351
Thymic cancer metastatic 14.39 11.34 5 57682 59 34899185
Blood pressure diastolic increased 14.37 11.34 28 57659 4997 34894247
Rash 14.37 11.34 270 57417 222482 34676762
Urinary tract disorder 14.30 11.34 18 57669 2206 34897038
Hypersomnia 14.24 11.34 49 57638 12358 34886886
Shock symptom 14.11 11.34 6 57681 126 34899118
Hallucination 13.91 11.34 138 57549 51360 34847884
Acute myocardial infarction 13.84 11.34 44 57643 53675 34845569
Brief psychotic disorder with marked stressors 13.75 11.34 7 57680 224 34899020
Infusion site mass 13.69 11.34 8 57679 338 34898906
Muscle spasticity 13.54 11.34 30 57657 5858 34893386
Bone marrow failure 13.54 11.34 17 57670 29236 34870008
COVID-19 13.47 11.34 74 57613 77476 34821768
Bladder cancer 13.46 11.34 5 57682 16273 34882971
Labelled drug-drug interaction medication error 13.38 11.34 4 57683 14935 34884309
Allodynia 13.28 11.34 11 57676 820 34898424
Paranasal sinus discomfort 13.17 11.34 11 57676 829 34898415
Palpitations 13.16 11.34 29 57658 39957 34859287
Myalgia 13.15 11.34 83 57604 84027 34815217
Postmortem blood drug level increased 13.13 11.34 7 57680 247 34898997
Facial wasting 13.11 11.34 6 57681 151 34899093
Ankle fracture 13.05 11.34 24 57663 4101 34895143
Hyperphosphataemia 13.02 11.34 25 57662 4412 34894832
Bone infarction 12.95 11.34 7 57680 254 34898990
Dyspnoea paroxysmal nocturnal 12.74 11.34 14 57673 1485 34897759
Allergy to chemicals 12.73 11.34 5 57682 85 34899159
Post-thoracotomy pain syndrome 12.48 11.34 4 57683 36 34899208
Fluid intake reduced 12.30 11.34 22 57665 3679 34895565
Ankylosing spondylitis 12.27 11.34 28 57659 5576 34893668
Tubulointerstitial nephritis 12.26 11.34 10 57677 21014 34878230
Treatment failure 12.21 11.34 38 57649 46659 34852585
Liver function test increased 12.17 11.34 52 57635 14513 34884731
Starvation 12.08 11.34 7 57680 291 34898953
Harlequin syndrome 12.08 11.34 3 57684 9 34899235
Administration related reaction 12.08 11.34 5 57682 98 34899146
Orthostatic hypotension 12.06 11.34 15 57672 25904 34873340
Pneumocystis jirovecii pneumonia 11.97 11.34 9 57678 19701 34879543
Blood pressure increased 11.91 11.34 208 57479 87894 34811350
Basal cell carcinoma 11.91 11.34 9 57678 19649 34879595
Device failure 11.86 11.34 17 57670 2359 34896885
Neck pain 11.82 11.34 77 57610 25272 34873972
Anal stenosis 11.82 11.34 6 57681 191 34899053
Thrombocytopenia 11.81 11.34 184 57503 156063 34743181
Aortic aneurysm 11.79 11.34 31 57656 6748 34892496
Autoimmune lung disease 11.77 11.34 4 57683 44 34899200
Postmortem blood drug level 11.70 11.34 6 57681 195 34899049
Withdrawal hypertension 11.70 11.34 6 57681 195 34899049
Failure to thrive 11.70 11.34 36 57651 8565 34890679
Eating disorder 11.69 11.34 35 57652 8205 34891039
Red cell distribution width increased 11.68 11.34 29 57658 6094 34893150
Gastrointestinal tract irritation 11.66 11.34 7 57680 311 34898933
Oxygen saturation decreased 11.65 11.34 138 57549 53680 34845564
Liver disorder 11.64 11.34 23 57664 32974 34866270
Hyperkalaemia 11.62 11.34 67 57620 69322 34829922
Needle issue 11.55 11.34 29 57658 6136 34893108
Carditis 11.46 11.34 6 57681 204 34899040
Odynophagia 11.45 11.34 27 57660 5494 34893750
Foetal exposure during pregnancy 11.44 11.34 29 57658 38072 34861172
International normalised ratio increased 11.35 11.34 40 57647 47287 34851957

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 371.26 10.06 1290 143551 297626 79301921
Temperature regulation disorder 292.70 10.06 163 144678 5690 79593857
Constipation 276.93 10.06 1132 143709 281918 79317629
Drug withdrawal syndrome 239.02 10.06 305 144536 34413 79565134
Nausea 214.91 10.06 2665 142176 954531 78645016
Food allergy 212.16 10.06 168 144673 10656 79588891
Hyperaesthesia 210.68 10.06 176 144665 12046 79587501
Appendicolith 203.50 10.06 149 144692 8402 79591145
Coeliac disease 196.78 10.06 164 144677 11187 79588360
Drug dependence 191.15 10.06 298 144543 40471 79559076
Somnolence 164.08 10.06 862 143979 238119 79361428
Pain 162.42 10.06 1971 142870 701831 78897716
Respiratory depression 148.09 10.06 215 144626 27415 79572132
Immunodeficiency 147.87 10.06 190 144651 21578 79577969
Exostosis 138.57 10.06 162 144679 16696 79582851
Joint dislocation 137.94 10.06 162 144679 16777 79582770
Drug interaction 133.71 10.06 353 144488 414830 79184717
Rheumatoid arthritis 132.92 10.06 737 144104 207733 79391814
Back pain 121.81 10.06 957 143884 303223 79296324
Vomiting 118.12 10.06 1779 143062 664049 78935498
Retinitis 113.64 10.06 89 144752 5554 79593993
Appendicitis 110.26 10.06 161 144680 20633 79578914
Sedation 107.46 10.06 269 144572 51626 79547921
Bursitis 102.29 10.06 211 144630 35633 79563914
Abdominal pain 97.48 10.06 1109 143732 388460 79211087
Bone erosion 97.28 10.06 140 144701 17707 79581840
Foot deformity 92.63 10.06 161 144680 23913 79575634
Hyperhidrosis 90.85 10.06 527 144314 150965 79448582
Stress 87.84 10.06 331 144510 79281 79520266
Delirium 87.76 10.06 345 144496 84282 79515265
Arthritis 87.59 10.06 427 144414 114453 79485094
Ankylosing spondylitis 86.80 10.06 109 144732 12096 79587451
General physical health deterioration 86.06 10.06 820 144021 274418 79325129
Unresponsive to stimuli 82.67 10.06 256 144585 55532 79544015
Toxicologic test abnormal 82.32 10.06 43 144798 1317 79598230
Medical device site pain 80.82 10.06 28 144813 295 79599252
Interstitial lung disease 80.03 10.06 53 144788 112547 79487000
Respiratory rate decreased 79.17 10.06 70 144771 5173 79594374
Hepatic cirrhosis 78.72 10.06 187 144654 34719 79564828
Pneumonia viral 78.61 10.06 90 144751 9068 79590479
Neutropenia 77.86 10.06 265 144576 287445 79312102
Procedural pain 76.88 10.06 145 144696 22939 79576608
Lower respiratory tract infection 75.38 10.06 74 144767 129146 79470401
Myocardial infarction 75.30 10.06 137 144704 183992 79415555
Intentional overdose 75.14 10.06 50 144791 105910 79493637
Acute kidney injury 73.65 10.06 597 144244 518807 79080740
Soft tissue disorder 69.83 10.06 55 144786 3460 79596087
Lupus-like syndrome 67.33 10.06 103 144738 13754 79585793
Blood phosphorus increased 66.67 10.06 88 144753 10259 79589288
Therapeutic product effect incomplete 65.89 10.06 462 144379 141183 79458364
Osteoporosis 65.60 10.06 232 144609 53880 79545667
Neoplasm progression 63.88 10.06 223 144618 51459 79548088
Cardiac failure congestive 63.71 10.06 100 144741 142302 79457245
Victim of child abuse 63.08 10.06 32 144809 921 79598626
Drug reaction with eosinophilia and systemic symptoms 61.44 10.06 20 144821 64224 79535323
Malignant neoplasm progression 58.88 10.06 436 144405 135554 79463993
Pneumonia aspiration 58.46 10.06 259 144582 66708 79532839
Laryngitis 57.50 10.06 104 144737 15935 79583612
Extremity contracture 57.35 10.06 37 144804 1695 79597852
Hepatic function abnormal 56.72 10.06 31 144810 73076 79526471
Inadequate analgesia 56.72 10.06 55 144786 4574 79594973
Cardiac failure 55.78 10.06 124 144717 154718 79444829
Hypermobility syndrome 53.64 10.06 24 144817 518 79599029
Macular degeneration 53.53 10.06 83 144758 11213 79588334
Joint stiffness 52.05 10.06 178 144663 40652 79558895
Sickle cell anaemia with crisis 52.01 10.06 68 144773 7854 79591693
Cardiogenic shock 51.06 10.06 180 144661 41734 79557813
Product dose omission issue 50.70 10.06 254 144587 247283 79352264
Muscle injury 50.33 10.06 13 144828 48548 79550999
Narcotic bowel syndrome 50.30 10.06 19 144822 261 79599286
Folliculitis 49.95 10.06 19 144822 55361 79544186
Orthostatic hypotension 49.45 10.06 20 144821 56144 79543403
Postmortem blood drug level abnormal 49.33 10.06 24 144817 630 79598917
Sleep disorder due to general medical condition, insomnia type 48.45 10.06 10 144831 43546 79556001
Abdominal distension 48.09 10.06 377 144464 119273 79480274
Incorrect route of product administration 47.83 10.06 156 144685 34773 79564774
Opiates positive 47.59 10.06 27 144814 977 79598570
Drug resistance 46.32 10.06 10 144831 42203 79557344
Breast cancer metastatic 46.18 10.06 67 144774 8535 79591012
Syncope 45.37 10.06 170 144671 179279 79420268
Epidural lipomatosis 45.07 10.06 28 144813 1200 79598347
Blood pressure systolic increased 44.76 10.06 240 144601 66746 79532801
Drug tolerance 44.30 10.06 66 144775 8609 79590938
Renal impairment 44.24 10.06 143 144698 157640 79441907
Hepatitis 44.16 10.06 23 144818 55704 79543843
Lactic acidosis 43.73 10.06 38 144803 70321 79529226
Rhabdomyolysis 43.71 10.06 75 144766 103056 79496491
Postoperative ileus 43.49 10.06 26 144815 1039 79598508
Suicide attempt 43.36 10.06 52 144789 82880 79516667
Alopecia 43.14 10.06 245 144596 231110 79368437
Ascites 42.14 10.06 258 144583 75304 79524243
Drug diversion 42.12 10.06 27 144814 1223 79598324
Duodenal ulcer perforation 42.08 10.06 35 144806 66176 79533371
Neuralgia 42.08 10.06 145 144696 33239 79566308
Irritable bowel syndrome 41.96 10.06 31 144810 62210 79537337
Implant site extravasation 41.47 10.06 23 144818 796 79598751
Mental status changes 41.46 10.06 235 144606 66724 79532823
Agranulocytosis 41.36 10.06 15 144826 45015 79554532
Bradycardia 40.02 10.06 120 144721 135437 79464110
Gastrointestinal haemorrhage 39.96 10.06 136 144705 147583 79451964
Chronic sinusitis 39.92 10.06 79 144762 12947 79586600
Plasma cell myeloma 39.88 10.06 197 144644 53062 79546485
Cytomegalovirus infection 39.52 10.06 14 144827 42630 79556917
Child abuse 39.30 10.06 18 144823 411 79599136
Decompression sickness 39.20 10.06 12 144829 82 79599465
Postmortem blood drug level increased 39.01 10.06 22 144819 787 79598760
Injection site pruritus 38.98 10.06 14 144827 42269 79557278
Coronary artery disease 38.75 10.06 37 144804 65437 79534110
Clostridium test positive 38.69 10.06 53 144788 6401 79593146
Hepatocellular injury 38.67 10.06 19 144822 47574 79551973
Poor venous access 38.53 10.06 95 144746 18054 79581493
Small intestinal obstruction 38.42 10.06 123 144718 27149 79572398
Vaginal flatulence 38.13 10.06 34 144807 2541 79597006
Malaise 37.94 10.06 1161 143680 488708 79110839
Alanine aminotransferase increased 37.30 10.06 160 144681 162410 79437137
Apnoeic attack 37.09 10.06 20 144821 654 79598893
Device related thrombosis 36.93 10.06 34 144807 2649 79596898
Drug intolerance 36.75 10.06 679 144162 263440 79336107
Osteoarthritis 36.69 10.06 278 144563 87031 79512516
Foreign body embolism 36.03 10.06 8 144833 10 79599537
Blister 35.82 10.06 105 144736 119371 79480176
COVID-19 35.68 10.06 156 144685 157518 79442029
Fluid retention 35.61 10.06 233 144608 69576 79529971
Rash 35.30 10.06 791 144050 577567 79021980
Rash erythematous 35.27 10.06 202 144639 57567 79541980
Fatigue 35.25 10.06 2043 142798 927684 78671863
Helicobacter infection 35.08 10.06 45 144796 69659 79529888
Blepharospasm 35.01 10.06 48 144793 5803 79593744
Myoclonus 34.74 10.06 120 144721 27540 79572007
Systemic infection 34.66 10.06 63 144778 9689 79589858
Asthma 34.32 10.06 386 144455 134709 79464838
Blood pressure increased 33.94 10.06 556 144285 210804 79388743
Gastrooesophageal reflux disease 33.72 10.06 313 144528 103933 79495614
Hypoaesthesia 33.47 10.06 484 144357 178868 79420679
Myelosuppression 32.87 10.06 16 144825 40280 79559267
Acute myocardial infarction 32.67 10.06 56 144785 76980 79522567
Drug tolerance increased 32.56 10.06 18 144823 619 79598928
Cholestasis 32.56 10.06 28 144813 52081 79547466
Product used for unknown indication 32.50 10.06 25 144816 1519 79598028
Injection site swelling 32.39 10.06 23 144818 47109 79552438
Anaesthetic complication neurological 32.38 10.06 18 144823 626 79598921
Apnoea 32.33 10.06 68 144773 11636 79587911
Melaena 32.02 10.06 38 144803 60852 79538695
Scar 31.69 10.06 79 144762 15117 79584430
Inappropriate schedule of product administration 31.35 10.06 376 144465 133252 79466295
Drug eruption 30.78 10.06 21 144820 43914 79555633
Overwork 30.54 10.06 9 144832 53 79599494
Maternal exposure during pregnancy 30.34 10.06 136 144705 136402 79463145
Eosinophilia 30.03 10.06 23 144818 45322 79554225
Accidental death 30.00 10.06 38 144803 4253 79595294
Migraine 29.98 10.06 266 144575 87227 79512320
Chest injury 29.93 10.06 31 144810 2790 79596757
Ventricular fibrillation 29.79 10.06 126 144715 31800 79567747
Status epilepticus 29.45 10.06 5 144836 25036 79574511
Impaired healing 29.31 10.06 73 144768 87582 79511965
Blood pressure fluctuation 28.89 10.06 215 144626 66930 79532617
Xyphoid retraction 28.43 10.06 11 144830 162 79599385
Drug abuse 28.39 10.06 434 144407 162257 79437290
Anaemia of malignant disease 28.25 10.06 18 144823 807 79598740
Cerebral haemorrhage 28.24 10.06 38 144803 57635 79541912
Cerebrovascular accident 28.10 10.06 166 144675 155126 79444421
Acute chest syndrome 27.98 10.06 23 144818 1538 79598009
Neurotoxicity 27.79 10.06 125 144716 32393 79567154
Arthropathy 27.65 10.06 198 144643 176913 79422634
Overdose 27.53 10.06 479 144362 183727 79415820
Rhesus antigen positive 27.40 10.06 10 144831 124 79599423
Injection site erythema 27.03 10.06 64 144777 78133 79521414
Rash pruritic 26.91 10.06 56 144785 71573 79527974
Device failure 26.91 10.06 44 144797 6217 79593330
Cerebral infarction 26.81 10.06 26 144815 45650 79553897
Pustular psoriasis 26.63 10.06 38 144803 4768 79594779
Arachnoiditis 26.60 10.06 17 144824 766 79598781
Hyperkalaemia 26.60 10.06 112 144729 114286 79485261
Renal failure 26.59 10.06 235 144606 200733 79398814
Transient ischaemic attack 26.54 10.06 34 144807 52661 79546886
Metastases to bone 26.46 10.06 101 144740 24326 79575221
Red cell distribution width increased 26.45 10.06 74 144767 15168 79584379
Sepsis 26.29 10.06 658 144183 268770 79330777
Alveolitis 26.08 10.06 35 144806 4145 79595402
Nephrolithiasis 26.05 10.06 176 144665 53115 79546432
Biliary tract infection 26.04 10.06 21 144820 1367 79598180
Tissue infiltration 25.98 10.06 16 144825 675 79598872
Tubulointerstitial nephritis 25.83 10.06 19 144822 38216 79561331
Secondary amyloidosis 25.77 10.06 11 144830 211 79599336
Aspartate aminotransferase increased 25.73 10.06 147 144694 138494 79461053
Platelet aggregation inhibition 25.67 10.06 10 144831 150 79599397
Extrapyramidal disorder 25.65 10.06 5 144836 22674 79576873
Oral pain 25.52 10.06 120 144721 31678 79567869
Heart rate increased 25.45 10.06 333 144508 120391 79479156
Electrocardiogram QT prolonged 25.27 10.06 82 144759 90304 79509243
Abortion spontaneous 25.18 10.06 11 144830 29496 79570051
Substance dependence 25.10 10.06 14 144827 490 79599057
Pneumocystis jirovecii pneumonia 24.90 10.06 14 144827 32494 79567053
Allodynia 24.88 10.06 22 144819 1626 79597921
Palpitations 24.72 10.06 132 144709 126478 79473069
Pregnancy 24.57 10.06 9 144832 26842 79572705
Amputation stump pain 24.55 10.06 7 144834 36 79599511
Drug ineffective 24.32 10.06 2278 142563 1078635 78520912
Ligament pain 24.18 10.06 11 144830 247 79599300
Prostate cancer metastatic 24.17 10.06 33 144808 3974 79595573
Ear infection 24.12 10.06 125 144716 34307 79565240
Radiculopathy 24.07 10.06 51 144790 8773 79590774
Death 23.97 10.06 1258 143583 565256 79034291
Systemic lupus erythematosus 23.82 10.06 126 144715 121023 79478524
Labelled drug-drug interaction issue 23.63 10.06 20 144821 1393 79598154
Infusion related reaction 23.57 10.06 566 144275 229671 79369876
Withdrawal syndrome 23.53 10.06 104 144737 26750 79572797
Infusion site mass 23.52 10.06 21 144820 1572 79597975
Device power source issue 23.41 10.06 17 144824 946 79598601
Intentional self-injury 23.38 10.06 15 144826 32404 79567143
Hypoglycaemia 23.29 10.06 100 144741 101494 79498053
Red blood cell sedimentation rate increased 23.22 10.06 153 144688 45789 79553758
Sinusitis 23.14 10.06 235 144606 195266 79404281
Weight decreased 23.13 10.06 825 144016 354373 79245174
Hypertensive encephalopathy 23.11 10.06 17 144824 965 79598582
Red blood cell sedimentation rate abnormal 22.93 10.06 5 144836 20958 79578589
Respiratory arrest 22.92 10.06 181 144660 57369 79542178
Taste disorder 22.87 10.06 72 144769 15751 79583796
Sopor 22.83 10.06 16 144825 32994 79566553
Bacillus infection 22.79 10.06 18 144823 1137 79598410
Hypoxia 22.70 10.06 287 144554 102956 79496591
Pulmonary fibrosis 22.69 10.06 28 144813 44084 79555463
Myasthenia gravis 22.68 10.06 55 144786 10344 79589203
Rash maculo-papular 22.66 10.06 42 144799 56036 79543511
Febrile neutropenia 22.49 10.06 564 144277 230435 79369112
Paraesthesia oral 22.47 10.06 85 144756 20386 79579161
Progressive multifocal leukoencephalopathy 22.36 10.06 5 144836 20595 79578952
Glossodynia 22.31 10.06 104 144737 103233 79496314
Hereditary angioedema 22.27 10.06 37 144804 5298 79594249
Basal cell carcinoma 22.25 10.06 21 144820 37354 79562193
International normalised ratio increased 22.23 10.06 79 144762 84642 79514905
Prostate cancer 21.87 10.06 17 144824 33251 79566296
Bone marrow failure 21.80 10.06 37 144804 51070 79548477
Female genital tract fistula 21.74 10.06 39 144802 5936 79593611
Ischaemic stroke 21.69 10.06 17 144824 33114 79566433
Head banging 21.56 10.06 13 144828 528 79599019
Blood creatine phosphokinase increased 21.36 10.06 56 144785 66034 79533513
Acute generalised exanthematous pustulosis 21.30 10.06 3 144838 17251 79582296
Cholangitis infective 21.28 10.06 14 144827 663 79598884
Radiation necrosis 21.18 10.06 12 144829 433 79599114
Nervousness 21.16 10.06 118 144723 33297 79566250
Basal ganglion degeneration 21.11 10.06 12 144829 436 79599111
Labelled drug-drug interaction medication error 21.05 10.06 12 144829 27638 79571909
Swelling 20.77 10.06 273 144568 216438 79383109
Visual acuity reduced 20.76 10.06 14 144827 29455 79570092
Liver disorder 20.73 10.06 65 144776 72352 79527195
Bladder cancer 20.67 10.06 5 144836 19521 79580026
Rheumatoid factor negative 20.44 10.06 17 144824 1156 79598391
Intestinal obstruction 20.38 10.06 141 144700 42879 79556668
Hepatotoxicity 20.28 10.06 39 144802 51313 79548234
Ventricular tachycardia 20.16 10.06 28 144813 41907 79557640
Drug therapy 20.09 10.06 17 144824 1184 79598363
Stevens-Johnson syndrome 20.00 10.06 25 144816 39141 79560406
Pemphigus 19.90 10.06 103 144738 99479 79500068
Miliaria 19.72 10.06 19 144822 1567 79597980
Proctitis 19.70 10.06 39 144802 6393 79593154
Cryopyrin associated periodic syndrome 19.64 10.06 11 144830 388 79599159
Pancreatitis 19.29 10.06 200 144641 68375 79531172
Rib fracture 19.26 10.06 101 144740 27846 79571701
Diabetes mellitus inadequate control 19.24 10.06 10 144831 24254 79575293
Synovitis 19.06 10.06 382 144459 150352 79449195
Blood pressure diastolic increased 19.06 10.06 64 144777 14478 79585069
Blood immunoglobulin M decreased 18.82 10.06 17 144824 1292 79598255
Tumour pain 18.74 10.06 22 144819 2277 79597270
Decreased appetite 18.66 10.06 780 144061 341638 79257909
Hypothermia 18.60 10.06 9 144832 22737 79576810
Urticaria thermal 18.53 10.06 11 144830 434 79599113
Groin pain 18.43 10.06 59 144782 13021 79586526
Hyperthermia 18.37 10.06 5 144836 18032 79581515
Nightmare 18.19 10.06 94 144747 25767 79573780
Hypercapnia 18.16 10.06 46 144795 8889 79590658
Dyspnoea exertional 18.00 10.06 89 144752 86984 79512563
Malignant polyp 17.99 10.06 8 144833 170 79599377
Fistula 17.90 10.06 58 144783 12882 79586665
Cystitis 17.90 10.06 160 144681 52572 79546975
Limb mass 17.83 10.06 27 144814 3572 79595975
Sinus bradycardia 17.77 10.06 12 144829 25235 79574312
Type IIa hyperlipidaemia 17.71 10.06 9 144832 260 79599287
Herpes zoster 17.67 10.06 252 144589 92831 79506716
Pruritus 17.67 10.06 564 144277 394084 79205463
Administration site erythema 17.65 10.06 10 144831 361 79599186
Blood urea increased 17.62 10.06 39 144802 48751 79550796
Spinal cord compression 17.56 10.06 37 144804 6340 79593207
Immune-mediated hepatitis 17.51 10.06 27 144814 3629 79595918
Screaming 17.39 10.06 28 144813 3905 79595642
Neck pain 17.16 10.06 211 144630 75206 79524341
Forced expiratory flow decreased 17.10 10.06 9 144832 280 79599267
Administration site bruise 17.06 10.06 8 144833 193 79599354
Compartment syndrome 17.02 10.06 32 144809 5050 79594497
Gastrointestinal disorder 17.01 10.06 141 144700 122064 79477483
Device infusion issue 16.90 10.06 21 144820 2305 79597242
Body temperature decreased 16.82 10.06 108 144733 32037 79567510
Metabolic acidosis 16.69 10.06 85 144756 82444 79517103
Tenderness 16.68 10.06 86 144755 23556 79575991
Injection site pain 16.65 10.06 153 144688 129685 79469862
Platelet count decreased 16.61 10.06 251 144590 194413 79405134
Blood pressure diastolic abnormal 16.55 10.06 74 144767 19128 79580419
Psychomotor hyperactivity 16.55 10.06 5 144836 16844 79582703
Septic shock 16.50 10.06 143 144698 122658 79476889
Lupus vulgaris 16.44 10.06 25 144816 3321 79596226
Adiposis dolorosa 16.43 10.06 9 144832 304 79599243
Urticaria 16.42 10.06 237 144604 184964 79414583
Haematotoxicity 16.38 10.06 4 144837 15515 79584032
White blood cell count decreased 16.33 10.06 242 144599 188046 79411501
Dyspnoea 16.29 10.06 1338 143503 855687 78743860
Cardiac failure acute 16.24 10.06 7 144834 18922 79580625
Sleep disorder therapy 16.12 10.06 14 144827 1010 79598537
Spinal shock 16.11 10.06 5 144836 36 79599511
Anuria 16.10 10.06 9 144832 20954 79578593
Terminal insomnia 15.93 10.06 15 144826 1202 79598345
Frequent bowel movements 15.92 10.06 100 144741 29439 79570108
Atrial fibrillation 15.92 10.06 258 144583 197628 79401919
Scratch 15.91 10.06 42 144799 8321 79591226
Pelvic pain 15.90 10.06 57 144784 13324 79586223
Seasonal allergy 15.88 10.06 5 144836 16401 79583146
Painful respiration 15.84 10.06 25 144816 3428 79596119
Conjunctivitis 15.84 10.06 14 144827 25701 79573846
Tricuspid valve incompetence 15.82 10.06 8 144833 19704 79579843
Upper respiratory tract infection 15.81 10.06 243 144598 90925 79508622
Post procedural complication 15.66 10.06 85 144756 23744 79575803
Antasthmatic drug level 15.65 10.06 5 144836 40 79599507
Diarrhoea 15.64 10.06 1382 143459 879107 78720440
Myocardial ischaemia 15.59 10.06 14 144827 25505 79574042
Uterine enlargement 15.49 10.06 13 144828 895 79598652
Seizure like phenomena 15.44 10.06 18 144823 1849 79597698
Occipital neuralgia 15.35 10.06 10 144831 466 79599081
Pulmonary hypertension 15.34 10.06 41 144800 48039 79551508
Pain in extremity 15.28 10.06 809 144032 363729 79235818
Ocular procedural complication 15.25 10.06 10 144831 471 79599076
Thrombocytopenia 15.23 10.06 366 144475 264893 79334654
Oral candidiasis 15.17 10.06 99 144742 29529 79570018
Analgesic drug level 15.13 10.06 5 144836 45 79599502
Product substitution issue 15.12 10.06 9 144832 20247 79579300
Lymphopenia 15.09 10.06 20 144821 30537 79569010
Umbilical hernia 15.04 10.06 33 144808 5812 79593735
Microembolism 15.04 10.06 5 144836 46 79599501
Weight fluctuation 14.96 10.06 51 144790 11624 79587923
Full blood count abnormal 14.90 10.06 32 144809 40442 79559105
Hand deformity 14.87 10.06 119 144722 103800 79495747
Mitral valve incompetence 14.83 10.06 18 144823 28547 79571000
Juvenile idiopathic arthritis 14.73 10.06 29 144812 4734 79594813
Vaginal discharge 14.73 10.06 38 144803 7425 79592122
Photophobia 14.71 10.06 75 144766 20453 79579094
Epstein-Barr virus infection 14.67 10.06 4 144837 14412 79585135
Mucosal inflammation 14.64 10.06 79 144762 75501 79524046
Multiple sclerosis relapse 14.60 10.06 40 144801 46493 79553054
Tenosynovitis 14.59 10.06 5 144836 15549 79583998
Pancreatitis acute 14.57 10.06 44 144797 49560 79549987
Failure to thrive 14.54 10.06 51 144790 11793 79587754
Eye operation 14.53 10.06 19 144822 2194 79597353
Blood glucose increased 14.52 10.06 136 144705 114839 79484708
Mental disorder 14.48 10.06 102 144739 31200 79568347
Anaesthesia 14.42 10.06 10 144831 517 79599030
Salivary hypersecretion 14.38 10.06 4 144837 14220 79585327
Eye irritation 14.33 10.06 10 144831 20671 79578876
Pulmonary toxicity 14.29 10.06 3 144838 12911 79586636
Inappropriate antidiuretic hormone secretion 14.29 10.06 16 144825 26297 79573250
Heart rate irregular 14.26 10.06 105 144736 32574 79566973
Arthritis infective 14.20 10.06 40 144801 8231 79591316
Obstruction 14.18 10.06 28 144813 4582 79594965
Pericarditis 14.17 10.06 121 144720 104115 79495432
C-reactive protein abnormal 14.14 10.06 43 144798 48324 79551223
Atrioventricular septal defect 14.06 10.06 6 144835 115 79599432
Serotonin syndrome 13.96 10.06 134 144707 44893 79554654
Incision site swelling 13.94 10.06 8 144833 296 79599251
Hyperglycaemia 13.91 10.06 73 144768 70262 79529285
Silicon granuloma 13.86 10.06 3 144838 3 79599544
Lethargy 13.84 10.06 216 144625 81076 79518471
Circulatory collapse 13.69 10.06 30 144811 37638 79561909
Caesarean section 13.69 10.06 3 144838 12532 79587015
Anaphylactic shock 13.64 10.06 28 144813 35968 79563579
Aspergillus infection 13.63 10.06 9 144832 19152 79580395
Vitamin K deficiency 13.63 10.06 11 144830 717 79598830
Pulmonary arterial hypertension 13.57 10.06 19 144822 28347 79571200
Skin necrosis 13.55 10.06 8 144833 18079 79581468
Substance abuse 13.51 10.06 46 144795 10480 79589067
Altered state of consciousness 13.51 10.06 38 144803 43784 79555763
Anxiety 13.50 10.06 566 144275 247946 79351601
Treatment failure 13.47 10.06 223 144618 170263 79429284
Chronic kidney disease 13.45 10.06 68 144773 66086 79533461
Anti-cyclic citrullinated peptide antibody positive 13.43 10.06 92 144749 83051 79516496
Accidental overdose 13.38 10.06 120 144721 39461 79560086
Cholangitis sclerosing 13.38 10.06 20 144821 2617 79596930
Grip strength decreased 13.36 10.06 12 144829 21857 79577690
Abdominal tenderness 13.34 10.06 46 144795 10548 79588999
Haematuria 13.30 10.06 72 144769 68764 79530783
Monoplegia 13.29 10.06 25 144816 3946 79595601
Dysgeusia 13.27 10.06 56 144785 57121 79542426
Rhinitis allergic 13.27 10.06 3 144838 12266 79587281
Palmar-plantar erythrodysaesthesia syndrome 13.22 10.06 25 144816 33109 79566438
Obstructive airways disorder 13.21 10.06 23 144818 31436 79568111
Presyncope 13.10 10.06 35 144806 41019 79558528
Oxygen saturation abnormal 13.10 10.06 27 144814 4555 79594992
Osteonecrosis of jaw 12.94 10.06 38 144803 43188 79556359
Oxygen saturation decreased 12.82 10.06 316 144525 128731 79470816
Pathogen resistance 12.80 10.06 5 144836 14337 79585210
Schizophrenia 12.79 10.06 6 144835 15434 79584113
Lip dry 12.76 10.06 6 144835 15412 79584135
Spinal laminectomy 12.71 10.06 10 144831 628 79598919
Bone pain 12.70 10.06 156 144685 55586 79543961
Psychotic disorder 12.69 10.06 36 144805 41366 79558181
Abdominal pain lower 12.68 10.06 100 144741 31682 79567865
Postoperative delirium 12.63 10.06 8 144833 355 79599192
Shock 12.53 10.06 39 144802 43509 79556038
Ileus 12.47 10.06 86 144755 26125 79573422
Eastern Cooperative Oncology Group performance status worsened 12.44 10.06 17 144824 2048 79597499
Asphyxia 12.41 10.06 3 144838 11717 79587830
Aggression 12.40 10.06 49 144792 50909 79548638
Rubella 12.25 10.06 6 144835 160 79599387
Oesophageal infection 12.23 10.06 10 144831 664 79598883
Withdrawal hypertension 12.22 10.06 8 144833 376 79599171
Implant site haematoma 12.08 10.06 6 144835 165 79599382
Colorectal cancer metastatic 12.06 10.06 13 144828 1225 79598322
Lactobacillus infection 12.03 10.06 8 144833 386 79599161
Granulocytopenia 11.96 10.06 3 144838 11428 79588119
Adverse drug reaction 11.91 10.06 178 144663 66214 79533333
Live birth 11.80 10.06 10 144831 18734 79580813
Gastric infection 11.79 10.06 23 144818 3730 79595817
Clostridium difficile infection 11.77 10.06 124 144717 42561 79556986
Post procedural pulmonary embolism 11.70 10.06 7 144834 280 79599267
Treatment noncompliance 11.64 10.06 52 144789 52216 79547331
Purpura 11.59 10.06 11 144830 19516 79580031
Respiratory rate increased 11.57 10.06 73 144768 21527 79578020
Spinal pain 11.57 10.06 57 144784 15335 79584212
Hip surgery 11.53 10.06 21 144820 3234 79596313
Angina unstable 11.44 10.06 8 144833 16519 79583028
Delirium tremens 11.44 10.06 10 144831 728 79598819
Eczema 11.43 10.06 37 144804 40781 79558766
Hypopnoea 11.42 10.06 28 144813 5301 79594246
Gallbladder disorder 11.39 10.06 67 144774 19273 79580274
Central nervous system lesion 11.38 10.06 5 144836 13363 79586184
Infusion site granuloma 11.34 10.06 3 144838 11 79599536
Autoimmune lung disease 11.31 10.06 4 144837 45 79599502
Burkholderia test positive 11.29 10.06 9 144832 576 79598971
Brief psychotic disorder with marked stressors 11.23 10.06 7 144834 302 79599245
Device computer issue 11.21 10.06 5 144836 107 79599440
Blood triglycerides increased 11.20 10.06 13 144828 21027 79578520
Respiratory syncytial virus infection 11.13 10.06 40 144801 9362 79590185
Product storage error 11.04 10.06 8 144833 16218 79583329
Toxic leukoencephalopathy 11.04 10.06 12 144829 1142 79598405
Tuberculosis 11.00 10.06 7 144834 15191 79584356
Diabetic ketoacidosis 10.96 10.06 29 144812 34093 79565454
Colitis microscopic 10.94 10.06 3 144838 10765 79588782
No adverse event 10.92 10.06 33 144808 37159 79562388
Product prescribing error 10.90 10.06 127 144714 44686 79554861
Breast conserving surgery 10.85 10.06 10 144831 780 79598767
Abdominal discomfort 10.81 10.06 360 144481 250367 79349180
Odynophagia 10.80 10.06 45 144796 11282 79588265
Coma 10.77 10.06 249 144592 100400 79499147
Extradural haematoma 10.76 10.06 19 144822 2857 79596690
Jaundice 10.76 10.06 55 144786 53294 79546253
Headache 10.74 10.06 1350 143491 652422 78947125
Shock symptom 10.71 10.06 6 144835 212 79599335
Umbilical discharge 10.69 10.06 5 144836 120 79599427
Infective pulmonary exacerbation of cystic fibrosis 10.64 10.06 5 144836 12846 79586701
Reading disorder 10.61 10.06 11 144830 991 79598556
Bronchopulmonary aspergillosis 10.60 10.06 15 144826 22279 79577268
Coccygectomy 10.59 10.06 3 144838 15 79599532
Intestinal resection 10.58 10.06 22 144819 3735 79595812
Gastrointestinal mucosa hyperaemia 10.53 10.06 8 144833 477 79599070
Wheezing 10.44 10.06 149 144692 116515 79483032
Weight bearing difficulty 10.44 10.06 20 144821 3201 79596346
Complement factor C4 decreased 10.43 10.06 7 144834 343 79599204
Liver iron concentration abnormal 10.39 10.06 4 144837 58 79599489
Cardiomyopathy 10.39 10.06 23 144818 28751 79570796
Drug level increased 10.38 10.06 37 144804 39614 79559933
Disseminated intravascular coagulation 10.38 10.06 32 144809 35810 79563737
Intervertebral disc protrusion 10.36 10.06 76 144765 23545 79576002
Blood pressure systolic abnormal 10.32 10.06 60 144781 17187 79582360
Choroid melanoma 10.21 10.06 4 144837 61 79599486
Gross motor delay 10.18 10.06 5 144836 134 79599413
Metastases to liver 10.17 10.06 87 144754 28227 79571320
Hepatitis acute 10.14 10.06 8 144833 15534 79584013
Atrioventricular block first degree 10.13 10.06 5 144836 12486 79587061
Bladder perforation 10.13 10.06 7 144834 360 79599187
Chest discomfort 10.12 10.06 183 144658 137861 79461686
Colitis ulcerative 10.09 10.06 102 144739 34640 79564907
Lymphoedema 10.07 10.06 47 144794 12366 79587181
Cough 10.07 10.06 554 144287 366235 79233312

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N02AA03 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Natural opium alkaloids
ATC N02AA53 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Natural opium alkaloids
ATC N02AG04 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with antispasmodics
MeSH PA D000700 Analgesics
MeSH PA D000701 Analgesics, Opioid
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D009294 Narcotics
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35482 narcotic analgesic
CHEBI has role CHEBI:55322 mu-opioid agonists
FDA MoA N0000175684 Full Opioid Agonists
FDA EPC N0000175690 Opioid Agonist

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Pain indication 22253000
Cough indication 49727002
Severe pain indication 76948002
Common cold indication 82272006 DOID:10459
Acute postoperative pain indication 107401000119105
Severe Pain with Opioid Tolerance indication
Chronic Pain with Opioid Tolerance indication
Suicidal thoughts contraindication 6471006
Dependent drug abuse contraindication 6525002
Alcohol withdrawal delirium contraindication 8635005
Asthenia contraindication 13791008
Constipation contraindication 14760008 DOID:2089
Mood swings contraindication 18963009
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Alcohol intoxication contraindication 25702006
Complete atrioventricular block contraindication 27885002
Shock contraindication 27942005
Hypercapnia contraindication 29596007
Dehydration contraindication 34095006
Disorder of gallbladder contraindication 39621005 DOID:0060262
Hypothyroidism contraindication 40930008 DOID:1459
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Bradycardia contraindication 48867003
Hepatic failure contraindication 59927004
Ulcerative colitis contraindication 64766004 DOID:8577
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Urethral stricture contraindication 76618002
Decreased respiratory function contraindication 80954004
Injury of head contraindication 82271004
Cor pulmonale contraindication 83291003 DOID:8515
Pulmonary emphysema contraindication 87433001
Kidney disease contraindication 90708001 DOID:557
Acute abdominal pain contraindication 116290004
Neoplasm of brain contraindication 126952004 DOID:1319
Seizure disorder contraindication 128613002
Drug-induced psychosis contraindication 191483003 DOID:1742
Disease of liver contraindication 235856003 DOID:409
Morbid obesity contraindication 238136002 DOID:11981
Sepsis syndrome contraindication 238150007
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Exacerbation of asthma contraindication 281239006
Lesion of brain contraindication 301766008
Deficiency of cholinesterase contraindication 360607009
Coma contraindication 371632003
Primary adrenocortical insufficiency contraindication 373662000
Operation on gastrointestinal tract contraindication 386621005
Hypoxia contraindication 389086002
Central nervous system depression contraindication 418072004
Dysfunction of sphincter of Oddi contraindication 430887001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.67 acidic
pKa2 8.64 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Mu-type opioid receptor GPCR AGONIST Ki 9.55 CHEMBL CHEMBL
Kappa-type opioid receptor GPCR Ki 8.55 CHEMBL
Delta-type opioid receptor GPCR Ki 7.42 CHEMBL
Opioid receptor GPCR EC50 9 CHEMBL

External reference:

IDSource
4019779 VUID
N0000147870 NUI
D00839 KEGG_DRUG
71-68-1 SECONDARY_CAS_RN
4018035 VANDF
4019779 VANDF
C0012306 UMLSCUI
CHEBI:5790 CHEBI
CHEMBL398707 ChEMBL_ID
DB00327 DRUGBANK_ID
CHEMBL1237055 ChEMBL_ID
D004091 MESH_DESCRIPTOR_UI
5284570 PUBCHEM_CID
7082 IUPHAR_LIGAND_ID
1770 INN_ID
Q812464R06 UNII
203177 RXNORM
1470 MMSL
4848 MMSL
7015 MMSL
d00255 MMSL
001547 NDDF
004622 NDDF
387485001 SNOMEDCT_US
414428000 SNOMEDCT_US
44508008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-0264 TABLET 4 mg ORAL ANDA 33 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-0264 TABLET 4 mg ORAL ANDA 33 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-0264 TABLET 4 mg ORAL ANDA 33 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-0265 TABLET 8 mg ORAL ANDA 33 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-0265 TABLET 8 mg ORAL ANDA 33 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-0265 TABLET 8 mg ORAL ANDA 33 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-0386 SOLUTION 1 mg ORAL ANDA 33 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-0386 SOLUTION 1 mg ORAL ANDA 33 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-0386 SOLUTION 1 mg ORAL ANDA 33 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0406-3243 TABLET 2 mg ORAL ANDA 38 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0406-3243 TABLET 2 mg ORAL ANDA 38 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0406-3243 TABLET 2 mg ORAL ANDA 38 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0406-3244 TABLET 4 mg ORAL ANDA 38 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0406-3244 TABLET 4 mg ORAL ANDA 38 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0406-3244 TABLET 4 mg ORAL ANDA 38 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0406-3249 TABLET 8 mg ORAL ANDA 38 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0406-3249 TABLET 8 mg ORAL ANDA 38 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0406-3249 TABLET 8 mg ORAL ANDA 38 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-1283 INJECTION, SOLUTION 1 mg INTRAMUSCULAR NDA 35 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-1283 INJECTION, SOLUTION 1 mg INTRAMUSCULAR NDA 35 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-1283 INJECTION, SOLUTION 1 mg INTRAMUSCULAR NDA 35 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-1283 INJECTION, SOLUTION 1 mg INTRAMUSCULAR NDA 35 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-1304 INJECTION, SOLUTION 4 mg INTRAMUSCULAR NDA 33 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-1312 INJECTION, SOLUTION 2 mg INTRAMUSCULAR NDA 35 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-1312 INJECTION, SOLUTION 2 mg INTRAMUSCULAR NDA 35 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-1312 INJECTION, SOLUTION 2 mg INTRAMUSCULAR NDA 35 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-1312 INJECTION, SOLUTION 2 mg INTRAMUSCULAR NDA 35 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-1380 INJECTION, SOLUTION 4 mg INTRAMUSCULAR NDA 35 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-1380 INJECTION, SOLUTION 4 mg INTRAMUSCULAR NDA 35 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-1380 INJECTION, SOLUTION 4 mg INTRAMUSCULAR NDA 35 sections