hydrocortisone cypionate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
corticosteroids, except prednisolone derivatives 1390 508-99-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hydrocortisone cypionate
  • cortisol cypionate
  • hydrocortisone cyclopentylpropionate
  • Molecular weight: 486.65
  • Formula: C29H42O6
  • CLOGP: 5.04
  • LIPINSKI: 1
  • HAC: 6
  • HDO: 2
  • TPSA: 100.90
  • ALOGS: -5.17
  • ROTB: 7
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
S (Water solubility) 0.23 mg/mL Bocci G, Oprea TI, Benet LZ

Approvals:

DateAgencyCompanyOrphan
May 10, 1955 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:49167 anti-asthmatic drugs
CHEBI has role CHEBI:50857 anti-allergic drugs
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:88188 allergenic drug

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.94 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST CHEMBL CHEMBL

External reference:

IDSource
4017944 VUID
N0000179568 NUI
D00976 KEGG_DRUG
4017941 VANDF
4017944 VANDF
C0612688 UMLSCUI
CHEBI:5783 CHEBI
CHEBI:17650 CHEBI
CHEMBL1549 ChEMBL_ID
DB14541 DRUGBANK_ID
C029109 MESH_SUPPLEMENTAL_RECORD_UI
4XDY25L70B UNII
223253 PUBCHEM_CID
DB00741 DRUGBANK_ID
163524 RXNORM
2500 MMSL
4837 MMSL
4841 MMSL
d00254 MMSL
002147 NDDF
002150 NDDF
109063008 SNOMEDCT_US
16602005 SNOMEDCT_US
396458002 SNOMEDCT_US
C0020268 UMLSCUI
38 INN_ID
5754 PUBCHEM_CID
D006854 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None