Stem definition | Drug id | CAS RN |
---|---|---|
corticosteroids, except prednisolone derivatives | 1388 | 50-23-7 |
Dose | Unit | Route |
---|---|---|
30 | mg | O |
30 | mg | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.23 mg/mL | Bocci G, Oprea TI, Benet LZ |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 353.81 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Vd (Volume of distribution) | 0.38 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 5.70 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.20 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 1.60 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
May 27, 2021 | EMA | Diurnal Europe B.V. | |
Aug. 5, 1952 | FDA | MERCK |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Infusion related reaction | 600.87 | 9.84 | 2010 | 212648 | 243511 | 63030853 |
Pericarditis | 598.73 | 9.84 | 1353 | 213305 | 130226 | 63144138 |
Anti-cyclic citrullinated peptide antibody positive | 568.20 | 9.84 | 1230 | 213428 | 114982 | 63159382 |
Rheumatoid factor positive | 531.73 | 9.84 | 993 | 213665 | 83413 | 63190951 |
Wound | 521.83 | 9.84 | 1468 | 213190 | 161795 | 63112569 |
Duodenal ulcer perforation | 489.39 | 9.84 | 977 | 213681 | 86232 | 63188132 |
Discomfort | 479.21 | 9.84 | 1447 | 213211 | 165927 | 63108437 |
Helicobacter infection | 472.94 | 9.84 | 999 | 213659 | 91786 | 63182578 |
Completed suicide | 456.30 | 9.84 | 7 | 214651 | 145666 | 63128698 |
Hand deformity | 440.95 | 9.84 | 1362 | 213296 | 158095 | 63116269 |
Intentional product use issue | 418.34 | 9.84 | 1160 | 213498 | 126732 | 63147632 |
Glossodynia | 393.23 | 9.84 | 1414 | 213244 | 177462 | 63096902 |
Synovitis | 371.17 | 9.84 | 1430 | 213228 | 185488 | 63088876 |
Rheumatic fever | 364.46 | 9.84 | 578 | 214080 | 42533 | 63231831 |
Hepatic enzyme increased | 353.16 | 9.84 | 1487 | 213171 | 200841 | 63073523 |
Systemic lupus erythematosus | 348.91 | 9.84 | 1515 | 213143 | 207403 | 63066961 |
Toxicity to various agents | 348.00 | 9.84 | 202 | 214456 | 247048 | 63027316 |
Pemphigus | 342.46 | 9.84 | 1378 | 213280 | 182348 | 63092016 |
Adrenocortical insufficiency acute | 306.57 | 9.84 | 138 | 214520 | 1560 | 63272804 |
Swollen joint count increased | 285.11 | 9.84 | 469 | 214189 | 35585 | 63238779 |
Death | 283.60 | 9.84 | 521 | 214137 | 373860 | 62900504 |
Blister | 276.46 | 9.84 | 1016 | 213642 | 128798 | 63145566 |
Arthropathy | 272.31 | 9.84 | 1535 | 213123 | 233257 | 63041107 |
Type 2 diabetes mellitus | 266.28 | 9.84 | 635 | 214023 | 63233 | 63211131 |
Swelling | 255.95 | 9.84 | 1700 | 212958 | 273678 | 63000686 |
Hypersensitivity | 239.17 | 9.84 | 1751 | 212907 | 290934 | 62983430 |
Blood cholesterol increased | 237.56 | 9.84 | 779 | 213879 | 93253 | 63181111 |
Product use issue | 218.01 | 9.84 | 1383 | 213275 | 219137 | 63055227 |
Abdominal discomfort | 217.19 | 9.84 | 1838 | 212820 | 319047 | 62955317 |
Fall | 216.06 | 9.84 | 647 | 214011 | 391687 | 62882677 |
Drug abuse | 194.13 | 9.84 | 13 | 214645 | 72505 | 63201859 |
Drug intolerance | 191.68 | 9.84 | 1735 | 212923 | 306926 | 62967438 |
Folliculitis | 188.88 | 9.84 | 595 | 214063 | 69722 | 63204642 |
Irritable bowel syndrome | 185.53 | 9.84 | 657 | 214001 | 81755 | 63192609 |
Alopecia | 182.24 | 9.84 | 1842 | 212816 | 335694 | 62938670 |
Condition aggravated | 181.20 | 9.84 | 2117 | 212541 | 400100 | 62874264 |
Injury | 178.00 | 9.84 | 599 | 214059 | 72648 | 63201716 |
Drug interaction | 171.37 | 9.84 | 321 | 214337 | 228810 | 63045554 |
Maternal exposure during pregnancy | 164.63 | 9.84 | 1290 | 213368 | 218772 | 63055592 |
Muscle injury | 163.77 | 9.84 | 540 | 214118 | 64805 | 63209559 |
Intentional overdose | 161.45 | 9.84 | 28 | 214630 | 74124 | 63200240 |
Steroid withdrawal syndrome | 161.36 | 9.84 | 63 | 214595 | 482 | 63273882 |
Overdose | 152.06 | 9.84 | 101 | 214557 | 114977 | 63159387 |
Adrenal insufficiency | 151.08 | 9.84 | 240 | 214418 | 17675 | 63256689 |
Hip arthroplasty | 149.53 | 9.84 | 426 | 214232 | 47220 | 63227144 |
Drug hypersensitivity | 145.91 | 9.84 | 1649 | 213009 | 309038 | 62965326 |
Colitis ulcerative | 138.71 | 9.84 | 286 | 214372 | 25805 | 63248559 |
Fibromyalgia | 136.11 | 9.84 | 586 | 214072 | 79834 | 63194530 |
Sleep disorder due to general medical condition, insomnia type | 134.87 | 9.84 | 436 | 214222 | 51781 | 63222583 |
Treatment failure | 126 | 9.84 | 1124 | 213534 | 197919 | 63076445 |
Rash | 125.47 | 9.84 | 2623 | 212035 | 558248 | 62716116 |
Product dose omission issue | 118.55 | 9.84 | 401 | 214257 | 233912 | 63040452 |
Acute kidney injury | 116.80 | 9.84 | 476 | 214182 | 262939 | 63011425 |
Liver injury | 108.62 | 9.84 | 449 | 214209 | 60071 | 63214293 |
Contraindicated product administered | 107.92 | 9.84 | 1168 | 213490 | 216480 | 63057884 |
Knee arthroplasty | 105.95 | 9.84 | 413 | 214245 | 53793 | 63220571 |
Therapeutic product effect decreased | 105.34 | 9.84 | 1057 | 213601 | 192130 | 63082234 |
Deep vein thrombosis postoperative | 103.81 | 9.84 | 158 | 214500 | 11211 | 63263153 |
Impaired healing | 98.62 | 9.84 | 639 | 214019 | 101903 | 63172461 |
Prescribed overdose | 97.24 | 9.84 | 295 | 214363 | 33858 | 63240506 |
Joint swelling | 96.92 | 9.84 | 1601 | 213057 | 326065 | 62948299 |
Suicide attempt | 92.58 | 9.84 | 45 | 214613 | 60873 | 63213491 |
Inappropriate schedule of product administration | 91.64 | 9.84 | 634 | 214024 | 103331 | 63171033 |
Craniopharyngioma | 91.38 | 9.84 | 30 | 214628 | 128 | 63274236 |
Frequent bowel movements | 89.60 | 9.84 | 223 | 214435 | 22799 | 63251565 |
Off label use | 88.62 | 9.84 | 2941 | 211717 | 671521 | 62602843 |
Lip dry | 87.48 | 9.84 | 174 | 214484 | 15296 | 63259068 |
Blood pressure fluctuation | 85.77 | 9.84 | 347 | 214311 | 45970 | 63228394 |
Facet joint syndrome | 84.19 | 9.84 | 149 | 214509 | 11989 | 63262375 |
Device expulsion | 83.41 | 9.84 | 10 | 214648 | 34912 | 63239452 |
Autoimmune disorder | 82.86 | 9.84 | 181 | 214477 | 16996 | 63257368 |
Febrile bone marrow aplasia | 80.29 | 9.84 | 111 | 214547 | 7214 | 63267150 |
Anaemia | 79.55 | 9.84 | 623 | 214035 | 292807 | 62981557 |
Sedation | 77.49 | 9.84 | 18 | 214640 | 38791 | 63235573 |
General physical health deterioration | 77.06 | 9.84 | 1029 | 213629 | 200373 | 63073991 |
Adverse event | 76.99 | 9.84 | 440 | 214218 | 67119 | 63207245 |
Adjustment disorder with depressed mood | 76.98 | 9.84 | 130 | 214528 | 10074 | 63264290 |
Live birth | 76.39 | 9.84 | 225 | 214433 | 25405 | 63248959 |
Mobility decreased | 73.94 | 9.84 | 679 | 213979 | 120480 | 63153884 |
Musculoskeletal stiffness | 73.44 | 9.84 | 950 | 213708 | 183668 | 63090696 |
Hypofibrinogenaemia | 73.28 | 9.84 | 47 | 214611 | 1123 | 63273241 |
Lower respiratory tract infection | 73.08 | 9.84 | 726 | 213932 | 131581 | 63142783 |
Psoriatic arthropathy | 72.49 | 9.84 | 544 | 214114 | 90976 | 63183388 |
Cognitive disorder | 72.35 | 9.84 | 50 | 214608 | 55765 | 63218599 |
Lupus vulgaris | 70.51 | 9.84 | 94 | 214564 | 5900 | 63268464 |
Cerebrovascular accident | 69.22 | 9.84 | 165 | 214493 | 107859 | 63166505 |
Cardiac failure congestive | 68.57 | 9.84 | 130 | 214528 | 92303 | 63182061 |
Atrial fibrillation | 67.92 | 9.84 | 187 | 214471 | 116449 | 63157915 |
Drug tolerance decreased | 67.73 | 9.84 | 169 | 214489 | 17304 | 63257060 |
Myocardial infarction | 67.72 | 9.84 | 148 | 214510 | 99745 | 63174619 |
Renal impairment | 67.55 | 9.84 | 122 | 214536 | 88233 | 63186131 |
X-ray abnormal | 67.49 | 9.84 | 108 | 214550 | 8002 | 63266362 |
Secondary adrenocortical insufficiency | 67.08 | 9.84 | 48 | 214610 | 1380 | 63272984 |
Malignant neoplasm progression | 66.80 | 9.84 | 109 | 214549 | 82012 | 63192352 |
Nausea | 66.57 | 9.84 | 2295 | 212363 | 852176 | 62422188 |
Haemoglobin decreased | 66.25 | 9.84 | 260 | 214398 | 145225 | 63129139 |
Drug level below therapeutic | 66.18 | 9.84 | 82 | 214576 | 4784 | 63269580 |
Female genital tract fistula | 66.13 | 9.84 | 103 | 214555 | 7456 | 63266908 |
Syncope | 65.56 | 9.84 | 192 | 214466 | 117193 | 63157171 |
Pituitary tumour benign | 65.08 | 9.84 | 54 | 214604 | 1941 | 63272423 |
Interstitial lung disease | 64.91 | 9.84 | 68 | 214590 | 61840 | 63212524 |
Platelet count decreased | 64.81 | 9.84 | 190 | 214468 | 115932 | 63158432 |
Anti-cyclic citrullinated peptide antibody | 64.66 | 9.84 | 96 | 214562 | 6662 | 63267702 |
Neutropenia | 64.58 | 9.84 | 338 | 214320 | 174667 | 63099697 |
Peripheral venous disease | 64.58 | 9.84 | 154 | 214504 | 15323 | 63259041 |
Coma | 63.84 | 9.84 | 74 | 214584 | 64290 | 63210074 |
Wheezing | 63.08 | 9.84 | 545 | 214113 | 95050 | 63179314 |
Ill-defined disorder | 61.97 | 9.84 | 481 | 214177 | 81274 | 63193090 |
Dislocation of vertebra | 61.18 | 9.84 | 107 | 214551 | 8528 | 63265836 |
Full blood count abnormal | 60.82 | 9.84 | 16 | 214642 | 31701 | 63242663 |
Balance disorder | 60.65 | 9.84 | 121 | 214537 | 84301 | 63190063 |
White blood cell count decreased | 59.33 | 9.84 | 255 | 214403 | 138849 | 63135515 |
Injection site pain | 57.18 | 9.84 | 235 | 214423 | 129565 | 63144799 |
Wrong technique in product usage process | 56.28 | 9.84 | 77 | 214581 | 62263 | 63212101 |
Serotonin syndrome | 55.90 | 9.84 | 14 | 214644 | 28668 | 63245696 |
Gastrointestinal haemorrhage | 55.24 | 9.84 | 120 | 214538 | 81056 | 63193308 |
Cardio-respiratory arrest | 55.20 | 9.84 | 73 | 214585 | 59886 | 63214478 |
Disease progression | 54.86 | 9.84 | 221 | 214437 | 122537 | 63151827 |
Injection site erythema | 54.11 | 9.84 | 126 | 214532 | 83048 | 63191316 |
Depressed level of consciousness | 53.74 | 9.84 | 79 | 214579 | 61999 | 63212365 |
Intentional self-injury | 53.13 | 9.84 | 11 | 214647 | 25676 | 63248688 |
Cardiac failure | 52.58 | 9.84 | 142 | 214516 | 89000 | 63185364 |
Stomatitis | 51.47 | 9.84 | 705 | 213953 | 138020 | 63136344 |
Somnolence | 50.91 | 9.84 | 374 | 214284 | 178311 | 63096053 |
Breast cancer | 50.88 | 9.84 | 53 | 214605 | 48330 | 63226034 |
Electrocardiogram QT prolonged | 50.32 | 9.84 | 77 | 214581 | 59453 | 63214911 |
Blood creatinine increased | 49.54 | 9.84 | 143 | 214515 | 87701 | 63186663 |
Chronic obstructive pulmonary disease | 49.32 | 9.84 | 85 | 214573 | 62601 | 63211763 |
Suicidal ideation | 48.78 | 9.84 | 85 | 214573 | 62336 | 63212028 |
Rheumatoid arthritis | 48.41 | 9.84 | 587 | 214071 | 253232 | 63021132 |
Adverse drug reaction | 48.24 | 9.84 | 446 | 214212 | 79268 | 63195096 |
Pneumonia | 47.68 | 9.84 | 1178 | 213480 | 455589 | 62818775 |
Breast cancer stage III | 47.35 | 9.84 | 107 | 214551 | 10279 | 63264085 |
Tremor | 47.33 | 9.84 | 258 | 214400 | 131981 | 63142383 |
Respiratory arrest | 46.80 | 9.84 | 26 | 214632 | 32619 | 63241745 |
Joint range of motion decreased | 44.29 | 9.84 | 222 | 214436 | 32206 | 63242158 |
Hyperadrenocorticism | 43.31 | 9.84 | 22 | 214636 | 331 | 63274033 |
Intentional product misuse | 43.16 | 9.84 | 88 | 214570 | 60829 | 63213535 |
Urticaria | 43.11 | 9.84 | 794 | 213864 | 165008 | 63109356 |
Bradycardia | 42.92 | 9.84 | 117 | 214541 | 73110 | 63201254 |
Hypercholesterolaemia | 42.86 | 9.84 | 164 | 214494 | 21170 | 63253194 |
Product use in unapproved indication | 42.60 | 9.84 | 846 | 213812 | 178234 | 63096130 |
Weight increased | 42.60 | 9.84 | 1169 | 213489 | 259623 | 63014741 |
Cardiac arrest | 41.09 | 9.84 | 167 | 214491 | 92378 | 63181986 |
Loss of consciousness | 40.88 | 9.84 | 233 | 214425 | 117888 | 63156476 |
Injection site swelling | 40.72 | 9.84 | 61 | 214597 | 47511 | 63226853 |
Pulmonary fibrosis | 40.67 | 9.84 | 252 | 214406 | 39557 | 63234807 |
Hypotension | 40.10 | 9.84 | 664 | 213994 | 271940 | 63002424 |
Cardiac disorder | 39.89 | 9.84 | 69 | 214589 | 50747 | 63223617 |
Grip strength decreased | 39.69 | 9.84 | 165 | 214493 | 22122 | 63252242 |
Hypertension | 39.60 | 9.84 | 1230 | 213428 | 278073 | 62996291 |
Poor venous access | 39.57 | 9.84 | 125 | 214533 | 14660 | 63259704 |
Hospitalisation | 39.39 | 9.84 | 151 | 214507 | 84930 | 63189434 |
Wound infection | 39.31 | 9.84 | 160 | 214498 | 21250 | 63253114 |
Contusion | 39.16 | 9.84 | 719 | 213939 | 149325 | 63125039 |
Thrombocytopenia | 39.03 | 9.84 | 325 | 214333 | 150832 | 63123532 |
Prescribed underdose | 38.97 | 9.84 | 201 | 214457 | 29488 | 63244876 |
Adrenal suppression | 38.74 | 9.84 | 29 | 214629 | 895 | 63273469 |
Blood creatine phosphokinase increased | 38.46 | 9.84 | 28 | 214630 | 30402 | 63243962 |
Dehydration | 37.33 | 9.84 | 390 | 214268 | 172964 | 63101400 |
Faecal calprotectin increased | 37.32 | 9.84 | 50 | 214608 | 3153 | 63271211 |
Femur fracture | 37.26 | 9.84 | 52 | 214606 | 41704 | 63232660 |
Cortisol decreased | 37.14 | 9.84 | 32 | 214626 | 1212 | 63273152 |
Lactic acidosis | 36.92 | 9.84 | 45 | 214613 | 38242 | 63236122 |
Lower limb fracture | 36.81 | 9.84 | 171 | 214487 | 24050 | 63250314 |
Gastrointestinal disorder | 36.77 | 9.84 | 636 | 214022 | 130603 | 63143761 |
Anal fissure | 36.74 | 9.84 | 59 | 214599 | 4384 | 63269980 |
Feeling abnormal | 36.55 | 9.84 | 323 | 214335 | 148069 | 63126295 |
Orthostatic hypotension | 36.48 | 9.84 | 41 | 214617 | 36119 | 63238245 |
Accidental exposure to product | 36.25 | 9.84 | 24 | 214634 | 27381 | 63246983 |
Vaginal flatulence | 36.24 | 9.84 | 50 | 214608 | 3243 | 63271121 |
Therapy cessation | 35.99 | 9.84 | 30 | 214628 | 30427 | 63243937 |
Leukopenia | 35.89 | 9.84 | 137 | 214521 | 77153 | 63197211 |
Vaginal discharge | 35.69 | 9.84 | 89 | 214569 | 9109 | 63265255 |
Musculoskeletal injury | 35.43 | 9.84 | 14 | 214644 | 111 | 63274253 |
Multiple sclerosis relapse | 35.23 | 9.84 | 69 | 214589 | 48409 | 63225955 |
Arthralgia | 35.18 | 9.84 | 2304 | 212354 | 567406 | 62706958 |
Renal failure | 35.08 | 9.84 | 243 | 214415 | 117409 | 63156955 |
Bronchitis | 34.85 | 9.84 | 263 | 214395 | 124672 | 63149692 |
Human bocavirus infection | 34.63 | 9.84 | 20 | 214638 | 393 | 63273971 |
Blepharospasm | 34.57 | 9.84 | 68 | 214590 | 5928 | 63268436 |
Melaena | 34.56 | 9.84 | 31 | 214627 | 30334 | 63244030 |
Maternal exposure timing unspecified | 34.55 | 9.84 | 75 | 214583 | 7012 | 63267352 |
Hepatic function abnormal | 34.41 | 9.84 | 45 | 214613 | 37097 | 63237267 |
Drug withdrawal syndrome | 34.40 | 9.84 | 25 | 214633 | 27169 | 63247195 |
Metastases to bone | 34.33 | 9.84 | 14 | 214644 | 21005 | 63253359 |
Red blood cell sedimentation rate abnormal | 34.27 | 9.84 | 12 | 214646 | 19770 | 63254594 |
Therapeutic response shortened | 34.13 | 9.84 | 103 | 214555 | 11785 | 63262579 |
C-reactive protein | 33.95 | 9.84 | 60 | 214598 | 4822 | 63269542 |
Injection site reaction | 33.93 | 9.84 | 94 | 214564 | 58430 | 63215934 |
Pleural effusion | 33.82 | 9.84 | 181 | 214477 | 93029 | 63181335 |
Hypothalamic pituitary adrenal axis suppression | 33.68 | 9.84 | 15 | 214643 | 165 | 63274199 |
Proctitis | 32.95 | 9.84 | 63 | 214595 | 5378 | 63268986 |
Herpes zoster | 32.84 | 9.84 | 155 | 214503 | 82307 | 63192057 |
Seizure | 32.53 | 9.84 | 289 | 214369 | 132345 | 63142019 |
Hyperhidrosis | 32.51 | 9.84 | 222 | 214436 | 107614 | 63166750 |
Rhabdomyolysis | 32.42 | 9.84 | 62 | 214596 | 43889 | 63230475 |
Hypothalamo-pituitary disorder | 32.39 | 9.84 | 24 | 214634 | 729 | 63273635 |
Alanine aminotransferase increased | 32.10 | 9.84 | 212 | 214446 | 103558 | 63170806 |
Migraine | 31.95 | 9.84 | 509 | 214149 | 102837 | 63171527 |
Osteonecrosis of jaw | 31.08 | 9.84 | 44 | 214614 | 35079 | 63239285 |
Unevaluable event | 30.95 | 9.84 | 81 | 214577 | 51305 | 63223059 |
Acute myocardial infarction | 30.72 | 9.84 | 38 | 214620 | 32086 | 63242278 |
Therapy interrupted | 30.40 | 9.84 | 39 | 214619 | 32416 | 63241948 |
Creatinine renal clearance decreased | 29.83 | 9.84 | 9 | 214649 | 16299 | 63258065 |
Hepatotoxicity | 29.34 | 9.84 | 50 | 214608 | 36991 | 63237373 |
Eczema | 29.06 | 9.84 | 198 | 214460 | 32093 | 63242271 |
Liver function test abnormal | 28.98 | 9.84 | 76 | 214582 | 48105 | 63226259 |
Fistula | 28.86 | 9.84 | 89 | 214569 | 10304 | 63264060 |
Perfume sensitivity | 28.81 | 9.84 | 23 | 214635 | 782 | 63273582 |
Body temperature fluctuation | 28.68 | 9.84 | 37 | 214621 | 2248 | 63272116 |
Insulin-like growth factor increased | 28.17 | 9.84 | 24 | 214634 | 895 | 63273469 |
Aspartate aminotransferase increased | 28.14 | 9.84 | 184 | 214474 | 90093 | 63184271 |
Drug level decreased | 28.01 | 9.84 | 74 | 214584 | 7845 | 63266519 |
Night sweats | 27.97 | 9.84 | 270 | 214388 | 48544 | 63225820 |
Abortion spontaneous | 27.96 | 9.84 | 75 | 214583 | 47120 | 63227244 |
Asthenia | 27.71 | 9.84 | 1039 | 213619 | 382565 | 62891799 |
Nasopharyngitis | 27.60 | 9.84 | 1086 | 213572 | 253171 | 63021193 |
Neuroleptic malignant syndrome | 27.48 | 9.84 | 4 | 214654 | 12052 | 63262312 |
Skin ulcer | 27.36 | 9.84 | 66 | 214592 | 42979 | 63231385 |
Hypopituitarism | 27.33 | 9.84 | 26 | 214632 | 1122 | 63273242 |
Haematochezia | 27.24 | 9.84 | 289 | 214369 | 53255 | 63221109 |
Myelosuppression | 27.21 | 9.84 | 24 | 214634 | 23679 | 63250685 |
Pruritus | 27.00 | 9.84 | 1487 | 213171 | 359966 | 62914398 |
Fluid retention | 26.94 | 9.84 | 107 | 214551 | 59579 | 63214785 |
Oedema peripheral | 26.74 | 9.84 | 465 | 214193 | 189046 | 63085318 |
Obesity | 26.57 | 9.84 | 183 | 214475 | 29769 | 63244595 |
Dry eye | 26.30 | 9.84 | 62 | 214596 | 40699 | 63233665 |
Plasma cell myeloma | 26.18 | 9.84 | 51 | 214607 | 35854 | 63238510 |
Steroid dependence | 26.06 | 9.84 | 31 | 214627 | 1733 | 63272631 |
Urticaria thermal | 25.94 | 9.84 | 17 | 214641 | 422 | 63273942 |
Oedema | 25.88 | 9.84 | 469 | 214189 | 97153 | 63177211 |
International normalised ratio increased | 25.86 | 9.84 | 76 | 214582 | 46349 | 63228015 |
Agitation | 25.79 | 9.84 | 109 | 214549 | 59648 | 63214716 |
Rhinovirus infection | 25.68 | 9.84 | 51 | 214607 | 4478 | 63269886 |
Mucous stools | 25.50 | 9.84 | 49 | 214609 | 4199 | 63270165 |
Arrhythmia | 25.43 | 9.84 | 57 | 214601 | 38083 | 63236281 |
Insulin-like growth factor decreased | 25.03 | 9.84 | 16 | 214642 | 380 | 63273984 |
Device dislocation | 25.01 | 9.84 | 30 | 214628 | 25675 | 63248689 |
Salpingo-oophorectomy unilateral | 24.97 | 9.84 | 22 | 214636 | 859 | 63273505 |
Chronic kidney disease | 24.79 | 9.84 | 75 | 214583 | 45323 | 63229041 |
Drug level above therapeutic | 24.75 | 9.84 | 52 | 214606 | 4753 | 63269611 |
Neoplasm recurrence | 24.56 | 9.84 | 37 | 214621 | 2601 | 63271763 |
Blood glucose increased | 24.47 | 9.84 | 174 | 214484 | 83582 | 63190782 |
Normal tension glaucoma | 24.39 | 9.84 | 8 | 214650 | 34 | 63274330 |
Gait inability | 24.27 | 9.84 | 280 | 214378 | 52679 | 63221685 |
Herpes simplex oesophagitis | 24.08 | 9.84 | 12 | 214646 | 173 | 63274191 |
Dizziness | 24.07 | 9.84 | 1198 | 213460 | 428727 | 62845637 |
Natural killer-cell leukaemia | 23.92 | 9.84 | 10 | 214648 | 93 | 63274271 |
Ascites | 23.92 | 9.84 | 65 | 214593 | 40663 | 63233701 |
Thrombosis | 23.90 | 9.84 | 125 | 214533 | 64630 | 63209734 |
Renal disorder | 23.90 | 9.84 | 47 | 214611 | 32927 | 63241437 |
Sciatica | 23.85 | 9.84 | 198 | 214460 | 34126 | 63240238 |
Dyskinesia | 23.73 | 9.84 | 45 | 214613 | 31957 | 63242407 |
Complication associated with device | 23.65 | 9.84 | 14 | 214644 | 16964 | 63257400 |
Heart rate irregular | 23.57 | 9.84 | 143 | 214515 | 22278 | 63252086 |
Pulmonary hypertension | 23.53 | 9.84 | 57 | 214601 | 37066 | 63237298 |
Sleep disorder | 23.46 | 9.84 | 397 | 214261 | 81169 | 63193195 |
Pulmonary arterial hypertension | 23.43 | 9.84 | 25 | 214633 | 22552 | 63251812 |
Hypophysitis | 23.41 | 9.84 | 30 | 214628 | 1811 | 63272553 |
Drug eruption | 23.41 | 9.84 | 38 | 214620 | 28656 | 63245708 |
Diabetes insipidus | 23.29 | 9.84 | 36 | 214622 | 2589 | 63271775 |
Transient ischaemic attack | 23.12 | 9.84 | 59 | 214599 | 37694 | 63236670 |
Blood parathyroid hormone decreased | 22.90 | 9.84 | 3 | 214655 | 9788 | 63264576 |
Rheumatoid nodule | 22.72 | 9.84 | 15 | 214643 | 17140 | 63257224 |
Hypercalcaemia | 22.64 | 9.84 | 38 | 214620 | 28284 | 63246080 |
Anal fistula | 22.60 | 9.84 | 42 | 214616 | 3509 | 63270855 |
Perioral dermatitis | 22.58 | 9.84 | 13 | 214645 | 254 | 63274110 |
Exposure during pregnancy | 22.54 | 9.84 | 687 | 213971 | 154860 | 63119504 |
Musculoskeletal disorder | 22.40 | 9.84 | 22 | 214636 | 20622 | 63253742 |
Radiculopathy | 22.31 | 9.84 | 72 | 214586 | 8539 | 63265825 |
Dysarthria | 22.31 | 9.84 | 72 | 214586 | 42639 | 63231725 |
Dermatitis atopic | 22.27 | 9.84 | 78 | 214580 | 9646 | 63264718 |
Antithrombin III | 22.23 | 9.84 | 11 | 214647 | 156 | 63274208 |
Breast cancer female | 22.19 | 9.84 | 9 | 214649 | 13550 | 63260814 |
Walking aid user | 22.03 | 9.84 | 83 | 214575 | 10634 | 63263730 |
Tendon pain | 22.00 | 9.84 | 40 | 214618 | 3286 | 63271078 |
Basal cell carcinoma | 21.97 | 9.84 | 38 | 214620 | 27953 | 63246411 |
Hallucination | 21.85 | 9.84 | 103 | 214555 | 54714 | 63219650 |
Constipation | 21.84 | 9.84 | 586 | 214072 | 224357 | 63050007 |
Vision blurred | 21.79 | 9.84 | 202 | 214456 | 91722 | 63182642 |
Bursitis | 21.77 | 9.84 | 206 | 214452 | 36835 | 63237529 |
Device difficult to use | 21.76 | 9.84 | 8 | 214650 | 12788 | 63261576 |
Faecal volume decreased | 21.62 | 9.84 | 11 | 214647 | 166 | 63274198 |
Blood calcium decreased | 21.60 | 9.84 | 35 | 214623 | 26416 | 63247948 |
Colitis | 21.53 | 9.84 | 255 | 214403 | 48273 | 63226091 |
Neoplasm progression | 21.50 | 9.84 | 58 | 214600 | 36370 | 63237994 |
Product prescribing error | 21.27 | 9.84 | 35 | 214623 | 26254 | 63248110 |
Product quality issue | 21.24 | 9.84 | 57 | 214601 | 35808 | 63238556 |
Schizophrenia | 21.13 | 9.84 | 4 | 214654 | 9948 | 63264416 |
Cataract | 21.13 | 9.84 | 110 | 214548 | 56943 | 63217421 |
Coronary artery disease | 21.09 | 9.84 | 49 | 214609 | 32328 | 63242036 |
Poisoning deliberate | 20.87 | 9.84 | 6 | 214652 | 11212 | 63263152 |
Abdominal pain upper | 20.83 | 9.84 | 875 | 213783 | 205569 | 63068795 |
Metastases to liver | 20.53 | 9.84 | 30 | 214628 | 23609 | 63250755 |
Proctalgia | 20.51 | 9.84 | 56 | 214602 | 6054 | 63268310 |
Haematuria | 19.91 | 9.84 | 43 | 214615 | 29114 | 63245250 |
Aphasia | 19.88 | 9.84 | 52 | 214606 | 32948 | 63241416 |
Epistaxis | 19.85 | 9.84 | 154 | 214504 | 72571 | 63201793 |
Excessive eye blinking | 19.75 | 9.84 | 23 | 214635 | 1257 | 63273107 |
Vertigo | 19.72 | 9.84 | 120 | 214538 | 59767 | 63214597 |
Respiratory failure | 19.60 | 9.84 | 235 | 214423 | 101623 | 63172741 |
Metabolic acidosis | 19.58 | 9.84 | 82 | 214576 | 44987 | 63229377 |
Panniculitis | 19.56 | 9.84 | 7 | 214651 | 11378 | 63262986 |
Respiratory depression | 19.55 | 9.84 | 11 | 214647 | 13704 | 63260660 |
Pancytopenia | 19.29 | 9.84 | 222 | 214436 | 96711 | 63177653 |
Palmar-plantar erythrodysaesthesia syndrome | 19.23 | 9.84 | 30 | 214628 | 22985 | 63251379 |
Adrenal disorder | 19.03 | 9.84 | 26 | 214632 | 1671 | 63272693 |
Lung neoplasm malignant | 19.01 | 9.84 | 23 | 214635 | 19610 | 63254754 |
Hypoaesthesia | 18.90 | 9.84 | 722 | 213936 | 167671 | 63106693 |
Toxic skin eruption | 18.85 | 9.84 | 10 | 214648 | 12875 | 63261489 |
Airway peak pressure increased | 18.85 | 9.84 | 12 | 214646 | 283 | 63274081 |
Granuloma skin | 18.77 | 9.84 | 3 | 214655 | 8434 | 63265930 |
Road traffic accident | 18.76 | 9.84 | 198 | 214460 | 36434 | 63237930 |
Diaphragm muscle weakness | 18.58 | 9.84 | 6 | 214652 | 24 | 63274340 |
Therapeutic product effect incomplete | 18.56 | 9.84 | 304 | 214354 | 124752 | 63149612 |
Strongyloidiasis | 18.55 | 9.84 | 22 | 214636 | 1226 | 63273138 |
Secondary immunodeficiency | 18.32 | 9.84 | 23 | 214635 | 1360 | 63273004 |
Hypomagnesaemia | 18.31 | 9.84 | 44 | 214614 | 28693 | 63245671 |
Myoclonus | 18.30 | 9.84 | 16 | 214642 | 15852 | 63258512 |
Pneumonia aspiration | 18.20 | 9.84 | 58 | 214600 | 34482 | 63239882 |
Asphyxia | 18.16 | 9.84 | 54 | 214604 | 6127 | 63268237 |
Hypertensive crisis | 18.13 | 9.84 | 15 | 214643 | 15271 | 63259093 |
Drug resistance | 18.12 | 9.84 | 31 | 214627 | 22902 | 63251462 |
Meningitis candida | 18.11 | 9.84 | 7 | 214651 | 52 | 63274312 |
Gastroenteritis norovirus | 17.84 | 9.84 | 28 | 214630 | 2040 | 63272324 |
Injection site bruising | 17.75 | 9.84 | 77 | 214581 | 41833 | 63232531 |
Myalgia | 17.75 | 9.84 | 369 | 214289 | 146160 | 63128204 |
Joint effusion | 17.59 | 9.84 | 19 | 214639 | 17041 | 63257323 |
Neutrophil count decreased | 17.55 | 9.84 | 115 | 214543 | 56291 | 63218073 |
Diarrhoea | 17.52 | 9.84 | 2135 | 212523 | 713231 | 62561133 |
Sinusitis fungal | 17.50 | 9.84 | 26 | 214632 | 1805 | 63272559 |
Product storage error | 17.34 | 9.84 | 15 | 214643 | 14941 | 63259423 |
Osteopenia | 17.29 | 9.84 | 25 | 214633 | 19760 | 63254604 |
Injection site pruritus | 17.27 | 9.84 | 86 | 214572 | 45030 | 63229334 |
Skin fragility | 17.22 | 9.84 | 16 | 214642 | 670 | 63273694 |
Back pain | 17.19 | 9.84 | 724 | 213934 | 263421 | 63010943 |
Dystonia | 17.09 | 9.84 | 13 | 214645 | 13806 | 63260558 |
Tenosynovitis | 17.04 | 9.84 | 13 | 214645 | 13782 | 63260582 |
Parkinsonism | 16.97 | 9.84 | 7 | 214651 | 10432 | 63263932 |
Blood alkaline phosphatase increased | 16.97 | 9.84 | 81 | 214577 | 42886 | 63231478 |
Myelodysplastic syndrome | 16.89 | 9.84 | 19 | 214639 | 16735 | 63257629 |
Anticipatory anxiety | 16.88 | 9.84 | 21 | 214637 | 1230 | 63273134 |
Pseudohypoaldosteronism | 16.84 | 9.84 | 5 | 214653 | 14 | 63274350 |
Hypophagia | 16.81 | 9.84 | 52 | 214606 | 31207 | 63243157 |
Dysphagia | 16.81 | 9.84 | 205 | 214453 | 88380 | 63185984 |
Palpitations | 16.78 | 9.84 | 274 | 214384 | 112496 | 63161868 |
Hypogonadism | 16.72 | 9.84 | 8 | 214650 | 105 | 63274259 |
Bone disorder | 16.70 | 9.84 | 29 | 214629 | 21297 | 63253067 |
Clostridium difficile colitis | 16.69 | 9.84 | 123 | 214535 | 20446 | 63253918 |
Gastrointestinal toxicity | 16.68 | 9.84 | 3 | 214655 | 7738 | 63266626 |
Allergy test positive | 16.62 | 9.84 | 15 | 214643 | 605 | 63273759 |
Urinary retention | 16.59 | 9.84 | 50 | 214608 | 30251 | 63244113 |
Eczema herpeticum | 16.38 | 9.84 | 9 | 214649 | 160 | 63274204 |
No adverse event | 16.38 | 9.84 | 78 | 214580 | 41327 | 63233037 |
Dyspepsia | 16.34 | 9.84 | 457 | 214201 | 101739 | 63172625 |
Natural killer cell count decreased | 16.33 | 9.84 | 6 | 214652 | 38 | 63274326 |
Hepatitis | 16.31 | 9.84 | 74 | 214584 | 39714 | 63234650 |
Upper gastrointestinal haemorrhage | 16.30 | 9.84 | 24 | 214634 | 18828 | 63255536 |
Hyponatraemia | 16.28 | 9.84 | 273 | 214385 | 111627 | 63162737 |
Loss of employment | 16.15 | 9.84 | 28 | 214630 | 2216 | 63272148 |
Hypoxia | 16.13 | 9.84 | 127 | 214531 | 59665 | 63214699 |
B-lymphocyte count increased | 16.13 | 9.84 | 8 | 214650 | 114 | 63274250 |
Hyperkalaemia | 16.12 | 9.84 | 112 | 214546 | 54091 | 63220273 |
Anal abscess | 16.09 | 9.84 | 43 | 214615 | 4589 | 63269775 |
Ulcer | 15.83 | 9.84 | 41 | 214617 | 26066 | 63248298 |
Macular degeneration | 15.79 | 9.84 | 37 | 214621 | 24339 | 63250025 |
Metastases to lung | 15.77 | 9.84 | 12 | 214646 | 12738 | 63261626 |
Full blood count decreased | 15.68 | 9.84 | 41 | 214617 | 25983 | 63248381 |
Taste disorder | 15.57 | 9.84 | 89 | 214569 | 13573 | 63260791 |
Bone marrow failure | 15.56 | 9.84 | 49 | 214609 | 29241 | 63245123 |
Haematoma | 15.34 | 9.84 | 63 | 214595 | 34757 | 63239607 |
Muscle rigidity | 15.30 | 9.84 | 10 | 214648 | 11490 | 63262874 |
Red blood cell count decreased | 15.26 | 9.84 | 78 | 214580 | 40567 | 63233797 |
Hyperemesis gravidarum | 15.23 | 9.84 | 14 | 214644 | 578 | 63273786 |
Tendonitis | 15.18 | 9.84 | 116 | 214542 | 19499 | 63254865 |
Blood potassium increased | 15.17 | 9.84 | 24 | 214634 | 18285 | 63256079 |
Akathisia | 15.09 | 9.84 | 6 | 214652 | 9140 | 63265224 |
Pituitary tumour recurrent | 15.04 | 9.84 | 7 | 214651 | 86 | 63274278 |
Mitral valve incompetence | 15.02 | 9.84 | 27 | 214631 | 19567 | 63254797 |
Tardive dyskinesia | 15.00 | 9.84 | 5 | 214653 | 8497 | 63265867 |
Rectal haemorrhage | 14.96 | 9.84 | 241 | 214417 | 48789 | 63225575 |
Cerebral microangiopathy | 14.95 | 9.84 | 10 | 214648 | 257 | 63274107 |
Ventricular tachycardia | 14.90 | 9.84 | 28 | 214630 | 19951 | 63254413 |
Depression | 14.88 | 9.84 | 529 | 214129 | 195963 | 63078401 |
Catarrh | 14.81 | 9.84 | 22 | 214636 | 1527 | 63272837 |
Myocardial ischaemia | 14.78 | 9.84 | 13 | 214645 | 12846 | 63261518 |
Excessive skin | 14.78 | 9.84 | 8 | 214650 | 138 | 63274226 |
Defaecation urgency | 14.75 | 9.84 | 39 | 214619 | 4136 | 63270228 |
Sedation complication | 14.69 | 9.84 | 15 | 214643 | 13807 | 63260557 |
Neoplasm malignant | 14.47 | 9.84 | 52 | 214606 | 29809 | 63244555 |
Cough | 14.43 | 9.84 | 826 | 213832 | 291917 | 62982447 |
Psychotic disorder | 14.38 | 9.84 | 42 | 214616 | 25670 | 63248694 |
Sputum increased | 14.31 | 9.84 | 28 | 214630 | 2431 | 63271933 |
Abnormal behaviour | 14.30 | 9.84 | 32 | 214626 | 21394 | 63252970 |
Altered state of consciousness | 14.27 | 9.84 | 41 | 214617 | 25189 | 63249175 |
Drug specific antibody present | 14.26 | 9.84 | 39 | 214619 | 4220 | 63270144 |
Secondary hypogonadism | 14.23 | 9.84 | 7 | 214651 | 98 | 63274266 |
Breast cancer stage I | 14.14 | 9.84 | 3 | 214655 | 6886 | 63267478 |
Haematotoxicity | 14.13 | 9.84 | 7 | 214651 | 9369 | 63264995 |
Proteinuria | 14.13 | 9.84 | 27 | 214631 | 19118 | 63255246 |
Tuberculosis gastrointestinal | 14.09 | 9.84 | 11 | 214647 | 362 | 63274002 |
CSF lymphocyte count abnormal | 14.08 | 9.84 | 3 | 214655 | 0 | 63274364 |
Infection | 13.92 | 9.84 | 926 | 213732 | 228247 | 63046117 |
Pain in jaw | 13.88 | 9.84 | 88 | 214570 | 43408 | 63230956 |
C-reactive protein abnormal | 13.85 | 9.84 | 226 | 214432 | 45870 | 63228494 |
Pulmonary embolism | 13.79 | 9.84 | 295 | 214363 | 116389 | 63157975 |
Erythema nodosum | 13.77 | 9.84 | 42 | 214616 | 4833 | 63269531 |
Labelled drug-drug interaction medication error | 13.73 | 9.84 | 15 | 214643 | 13384 | 63260980 |
Pulmonary oedema | 13.69 | 9.84 | 119 | 214539 | 54754 | 63219610 |
Extrapyramidal disorder | 13.47 | 9.84 | 15 | 214643 | 13269 | 63261095 |
Mastocytosis | 13.44 | 9.84 | 13 | 214645 | 573 | 63273791 |
Blood potassium decreased | 13.42 | 9.84 | 85 | 214573 | 41941 | 63232423 |
Cerebral infarction | 13.39 | 9.84 | 39 | 214619 | 23854 | 63250510 |
Enterococcal sepsis | 13.36 | 9.84 | 20 | 214638 | 1398 | 63272966 |
Device malfunction | 13.34 | 9.84 | 25 | 214633 | 17832 | 63256532 |
Cellulitis | 13.25 | 9.84 | 196 | 214462 | 81762 | 63192602 |
Head injury | 13.08 | 9.84 | 48 | 214610 | 27348 | 63247016 |
Tongue disorder | 13.03 | 9.84 | 10 | 214648 | 10570 | 63263794 |
Oral candidiasis | 13.01 | 9.84 | 126 | 214532 | 22672 | 63251692 |
Hypoaldosteronism | 12.94 | 9.84 | 8 | 214650 | 179 | 63274185 |
Skin injury | 12.83 | 9.84 | 22 | 214636 | 1726 | 63272638 |
Embolism venous | 12.75 | 9.84 | 31 | 214627 | 3123 | 63271241 |
Abdominal pain | 12.75 | 9.84 | 1155 | 213503 | 292301 | 62982063 |
Blood urea increased | 12.74 | 9.84 | 46 | 214612 | 26333 | 63248031 |
Cerebral haemorrhage | 12.68 | 9.84 | 57 | 214601 | 30672 | 63243692 |
Synovial cyst | 12.67 | 9.84 | 10 | 214648 | 10423 | 63263941 |
Diabetic ketoacidosis | 12.59 | 9.84 | 32 | 214626 | 20473 | 63253891 |
Hip fracture | 12.57 | 9.84 | 54 | 214604 | 29420 | 63244944 |
Torsade de pointes | 12.55 | 9.84 | 16 | 214642 | 13335 | 63261029 |
Gastrointestinal scarring | 12.43 | 9.84 | 10 | 214648 | 344 | 63274020 |
Drug tolerance | 12.41 | 9.84 | 4 | 214654 | 6945 | 63267419 |
Carpal tunnel syndrome | 12.39 | 9.84 | 33 | 214625 | 20784 | 63253580 |
Atrial septal defect | 12.38 | 9.84 | 4 | 214654 | 6934 | 63267430 |
Transplant rejection | 12.27 | 9.84 | 11 | 214647 | 10769 | 63263595 |
Rash pruritic | 12.27 | 9.84 | 136 | 214522 | 59663 | 63214701 |
Dysgeusia | 12.24 | 9.84 | 100 | 214558 | 46610 | 63227754 |
Jaundice | 12.23 | 9.84 | 54 | 214604 | 29197 | 63245167 |
Aspergillus infection | 12.20 | 9.84 | 57 | 214601 | 8036 | 63266328 |
Insomnia | 12.17 | 9.84 | 599 | 214059 | 214653 | 63059711 |
Aborted pregnancy | 12.10 | 9.84 | 5 | 214653 | 45 | 63274319 |
Seronegative arthritis | 12.03 | 9.84 | 35 | 214623 | 3924 | 63270440 |
Pus in stool | 12.01 | 9.84 | 5 | 214653 | 46 | 63274318 |
Aggression | 12.00 | 9.84 | 40 | 214618 | 23458 | 63250906 |
Disorientation | 11.99 | 9.84 | 81 | 214577 | 39371 | 63234993 |
Vaginal haemorrhage | 11.95 | 9.84 | 50 | 214608 | 27437 | 63246927 |
Restlessness | 11.94 | 9.84 | 55 | 214603 | 29398 | 63244966 |
Acute generalised exanthematous pustulosis | 11.85 | 9.84 | 12 | 214646 | 11087 | 63263277 |
Brachycephaly | 11.84 | 9.84 | 4 | 214654 | 19 | 63274345 |
Ischaemic stroke | 11.84 | 9.84 | 27 | 214631 | 17930 | 63256434 |
Faecal calprotectin abnormal | 11.83 | 9.84 | 6 | 214652 | 90 | 63274274 |
White blood cell count increased | 11.81 | 9.84 | 106 | 214552 | 48455 | 63225909 |
Diffuse large B-cell lymphoma | 11.75 | 9.84 | 4 | 214654 | 6708 | 63267656 |
Breast cancer metastatic | 11.72 | 9.84 | 14 | 214644 | 12004 | 63262360 |
Delusion | 11.72 | 9.84 | 14 | 214644 | 12003 | 63262361 |
Tessellated fundus | 11.64 | 9.84 | 5 | 214653 | 50 | 63274314 |
Blood pressure systolic abnormal | 11.61 | 9.84 | 17 | 214641 | 13369 | 63260995 |
Mydriasis | 11.58 | 9.84 | 14 | 214644 | 11942 | 63262422 |
Pulmonary toxicity | 11.56 | 9.84 | 9 | 214649 | 9446 | 63264918 |
Neutrophilic panniculitis | 11.56 | 9.84 | 5 | 214653 | 51 | 63274313 |
Osteomyelitis | 11.51 | 9.84 | 47 | 214611 | 25973 | 63248391 |
Shared psychotic disorder | 11.51 | 9.84 | 4 | 214654 | 21 | 63274343 |
Hypoperfusion | 11.48 | 9.84 | 19 | 214639 | 1448 | 63272916 |
Increased bronchial secretion | 11.38 | 9.84 | 21 | 214637 | 1745 | 63272619 |
Duodenal ulcer | 11.38 | 9.84 | 6 | 214652 | 7750 | 63266614 |
Electrocardiogram QRS complex prolonged | 11.37 | 9.84 | 3 | 214655 | 5935 | 63268429 |
Anorectal ulcer | 11.31 | 9.84 | 5 | 214653 | 54 | 63274310 |
Norovirus test positive | 11.30 | 9.84 | 8 | 214650 | 226 | 63274138 |
Mental status changes | 11.21 | 9.84 | 83 | 214575 | 39516 | 63234848 |
Arteriosclerosis coronary artery | 11.20 | 9.84 | 57 | 214601 | 8316 | 63266048 |
Blood pressure diastolic abnormal | 11.18 | 9.84 | 20 | 214638 | 14522 | 63259842 |
Pneumatosis intestinalis | 11.16 | 9.84 | 25 | 214633 | 2388 | 63271976 |
Chromaturia | 11.13 | 9.84 | 25 | 214633 | 16692 | 63257672 |
PO2 decreased | 11.11 | 9.84 | 19 | 214639 | 1487 | 63272877 |
Neutropenic infection | 11.10 | 9.84 | 18 | 214640 | 1349 | 63273015 |
Non-consummation | 11.07 | 9.84 | 5 | 214653 | 57 | 63274307 |
Pancreatic carcinoma | 11.04 | 9.84 | 6 | 214652 | 7622 | 63266742 |
Pyoderma gangrenosum | 10.97 | 9.84 | 32 | 214626 | 3593 | 63270771 |
Tendon rupture | 10.96 | 9.84 | 56 | 214602 | 8183 | 63266181 |
Hypervolaemia | 10.96 | 9.84 | 54 | 214604 | 28359 | 63246005 |
Adrenocorticotropic hormone deficiency | 10.96 | 9.84 | 10 | 214648 | 409 | 63273955 |
Eye injury | 10.94 | 9.84 | 28 | 214630 | 2911 | 63271453 |
Electrocardiogram abnormal | 10.90 | 9.84 | 9 | 214649 | 9170 | 63265194 |
Skin necrosis | 10.89 | 9.84 | 19 | 214639 | 13931 | 63260433 |
Burns second degree | 10.89 | 9.84 | 22 | 214636 | 1956 | 63272408 |
Ankle fracture | 10.86 | 9.84 | 28 | 214630 | 17827 | 63256537 |
Confusional state | 10.82 | 9.84 | 934 | 213724 | 235446 | 63038918 |
Febrile neutropenia | 10.82 | 9.84 | 497 | 214161 | 117952 | 63156412 |
Enthesopathy | 10.79 | 9.84 | 8 | 214650 | 8606 | 63265758 |
Injection site mass | 10.78 | 9.84 | 30 | 214628 | 18626 | 63255738 |
Invasive ductal breast carcinoma | 10.78 | 9.84 | 5 | 214653 | 6953 | 63267411 |
Gamma-glutamyltransferase increased | 10.78 | 9.84 | 69 | 214589 | 33962 | 63240402 |
Glomerular filtration rate decreased | 10.78 | 9.84 | 18 | 214640 | 13423 | 63260941 |
Subdural haematoma | 10.75 | 9.84 | 20 | 214638 | 14308 | 63260056 |
Skin weeping | 10.74 | 9.84 | 13 | 214645 | 740 | 63273624 |
Blood pressure abnormal | 10.72 | 9.84 | 22 | 214636 | 15176 | 63259188 |
Mood altered | 10.70 | 9.84 | 21 | 214637 | 14722 | 63259642 |
Immunodeficiency | 10.68 | 9.84 | 34 | 214624 | 20220 | 63254144 |
Pneumatosis | 10.64 | 9.84 | 10 | 214648 | 425 | 63273939 |
Pain | 10.64 | 9.84 | 2737 | 211921 | 737891 | 62536473 |
Leukoencephalopathy | 10.63 | 9.84 | 36 | 214622 | 4377 | 63269987 |
Hepatic rupture | 10.63 | 9.84 | 5 | 214653 | 63 | 63274301 |
Platelet count increased | 10.60 | 9.84 | 28 | 214630 | 17683 | 63256681 |
Enterovirus infection | 10.57 | 9.84 | 15 | 214643 | 999 | 63273365 |
Blood corticotrophin decreased | 10.56 | 9.84 | 9 | 214649 | 336 | 63274028 |
Foetal death | 10.48 | 9.84 | 13 | 214645 | 10967 | 63263397 |
Laboratory test abnormal | 10.47 | 9.84 | 51 | 214607 | 26861 | 63247503 |
White blood cell count abnormal | 10.45 | 9.84 | 4 | 214654 | 6238 | 63268126 |
Bone density decreased | 10.44 | 9.84 | 21 | 214637 | 14591 | 63259773 |
Intermenstrual bleeding | 10.40 | 9.84 | 7 | 214651 | 7919 | 63266445 |
Therapy non-responder | 10.39 | 9.84 | 333 | 214325 | 75568 | 63198796 |
Accidental overdose | 10.38 | 9.84 | 42 | 214616 | 23267 | 63251097 |
Status asthmaticus | 10.36 | 9.84 | 14 | 214644 | 890 | 63273474 |
Retinitis | 10.36 | 9.84 | 45 | 214613 | 6151 | 63268213 |
Therapeutic reaction time decreased | 10.34 | 9.84 | 24 | 214634 | 2346 | 63272018 |
Respiratory tract infection | 10.33 | 9.84 | 90 | 214568 | 41393 | 63232971 |
Miosis | 10.33 | 9.84 | 6 | 214652 | 7347 | 63267017 |
Injection site rash | 10.32 | 9.84 | 31 | 214627 | 18778 | 63255586 |
Surgery | 10.29 | 9.84 | 75 | 214583 | 35837 | 63238527 |
Lymphocyte count decreased | 10.29 | 9.84 | 60 | 214598 | 30197 | 63244167 |
Jaundice cholestatic | 10.26 | 9.84 | 6 | 214652 | 7318 | 63267046 |
Vaginal abscess | 10.26 | 9.84 | 10 | 214648 | 445 | 63273919 |
Optic glioma | 10.21 | 9.84 | 3 | 214655 | 8 | 63274356 |
Product administration error | 10.20 | 9.84 | 40 | 214618 | 22357 | 63252007 |
Dyspnoea exertional | 10.17 | 9.84 | 143 | 214515 | 60159 | 63214205 |
Glucocorticoid deficiency | 10.12 | 9.84 | 8 | 214650 | 268 | 63274096 |
Heart rate decreased | 10.08 | 9.84 | 213 | 214445 | 45347 | 63229017 |
Aplastic anaemia | 10.04 | 9.84 | 61 | 214597 | 9508 | 63264856 |
Astrocytoma | 10.04 | 9.84 | 5 | 214653 | 72 | 63274292 |
Spondylitis | 10.04 | 9.84 | 35 | 214623 | 4319 | 63270045 |
Blood growth hormone increased | 9.98 | 9.84 | 10 | 214648 | 460 | 63273904 |
Eating disorder | 9.97 | 9.84 | 32 | 214626 | 18984 | 63255380 |
Cerebral vasoconstriction | 9.93 | 9.84 | 16 | 214642 | 1192 | 63273172 |
Nodule | 9.93 | 9.84 | 37 | 214621 | 20989 | 63253375 |
Geotrichum infection | 9.91 | 9.84 | 10 | 214648 | 464 | 63273900 |
Abortion induced | 9.91 | 9.84 | 12 | 214646 | 10230 | 63264134 |
Pituitary infarction | 9.88 | 9.84 | 4 | 214654 | 34 | 63274330 |
Visual pathway disorder | 9.88 | 9.84 | 4 | 214654 | 34 | 63274330 |
Muscle spasticity | 9.88 | 9.84 | 39 | 214619 | 21755 | 63252609 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Intentional product use issue | 276.87 | 10.17 | 537 | 92258 | 59279 | 34804857 |
Blood pressure fluctuation | 247.61 | 10.17 | 320 | 92475 | 24929 | 34839207 |
Adrenal insufficiency | 233.27 | 10.17 | 234 | 92561 | 13813 | 34850323 |
Drug abuse | 224.03 | 10.17 | 9 | 92786 | 99087 | 34765049 |
Completed suicide | 203.09 | 10.17 | 15 | 92780 | 98153 | 34765983 |
Toxicity to various agents | 196.64 | 10.17 | 147 | 92648 | 200215 | 34663921 |
Off label use | 191.35 | 10.17 | 1822 | 90973 | 417702 | 34446434 |
Death | 187.24 | 10.17 | 496 | 92299 | 397553 | 34466583 |
Inappropriate schedule of product administration | 177.47 | 10.17 | 461 | 92334 | 61835 | 34802301 |
Craniopharyngioma | 166.29 | 10.17 | 52 | 92743 | 247 | 34863889 |
Adrenocortical insufficiency acute | 153.29 | 10.17 | 78 | 92717 | 1522 | 34862614 |
Infusion related reaction | 152.50 | 10.17 | 394 | 92401 | 52663 | 34811473 |
Graft loss | 133.68 | 10.17 | 59 | 92736 | 824 | 34863312 |
Condition aggravated | 131.15 | 10.17 | 916 | 91879 | 191280 | 34672856 |
Frequent bowel movements | 126.79 | 10.17 | 163 | 92632 | 12624 | 34851512 |
Colitis ulcerative | 126.71 | 10.17 | 186 | 92609 | 16334 | 34847802 |
Febrile bone marrow aplasia | 115.20 | 10.17 | 125 | 92670 | 8084 | 34856052 |
Serum sickness | 108.19 | 10.17 | 67 | 92728 | 1933 | 34862203 |
Adrenal suppression | 106.97 | 10.17 | 46 | 92749 | 601 | 34863535 |
Heart rate decreased | 99.82 | 10.17 | 244 | 92551 | 31501 | 34832635 |
Hypofibrinogenaemia | 89.99 | 10.17 | 56 | 92739 | 1630 | 34862506 |
Febrile neutropenia | 83.86 | 10.17 | 636 | 92159 | 136213 | 34727923 |
Bronchiectasis | 83.46 | 10.17 | 116 | 92679 | 9685 | 34854451 |
Aplastic anaemia | 82.75 | 10.17 | 115 | 92680 | 9601 | 34854535 |
Heart rate irregular | 81.84 | 10.17 | 149 | 92646 | 15658 | 34848478 |
Faecal calprotectin increased | 80.02 | 10.17 | 61 | 92734 | 2483 | 34861653 |
Hypopituitarism | 79.10 | 10.17 | 58 | 92737 | 2224 | 34861912 |
Impaired quality of life | 77.14 | 10.17 | 86 | 92709 | 5732 | 34858404 |
Intentional overdose | 74.55 | 10.17 | 13 | 92782 | 43661 | 34820475 |
Drug level below therapeutic | 74.45 | 10.17 | 83 | 92712 | 5532 | 34858604 |
Diabetes insipidus | 66.36 | 10.17 | 58 | 92737 | 2870 | 34861266 |
Drug interaction | 66.02 | 10.17 | 342 | 92453 | 225604 | 34638532 |
Leukoencephalopathy | 65.92 | 10.17 | 68 | 92727 | 4147 | 34859989 |
Interstitial lung disease | 65.05 | 10.17 | 47 | 92748 | 65235 | 34798901 |
Product use issue | 64.55 | 10.17 | 335 | 92460 | 62881 | 34801255 |
Drug specific antibody present | 64.46 | 10.17 | 60 | 92735 | 3225 | 34860911 |
Overdose | 60.97 | 10.17 | 92 | 92703 | 90967 | 34773169 |
Body temperature fluctuation | 59.21 | 10.17 | 43 | 92752 | 1624 | 34862512 |
Steroid withdrawal syndrome | 56.03 | 10.17 | 22 | 92773 | 224 | 34863912 |
Steroid dependence | 55.87 | 10.17 | 40 | 92755 | 1477 | 34862659 |
Cortisol decreased | 54.08 | 10.17 | 35 | 92760 | 1092 | 34863044 |
Mucosal inflammation | 52.89 | 10.17 | 223 | 92572 | 38399 | 34825737 |
Arthralgia | 51.56 | 10.17 | 683 | 92112 | 169358 | 34694778 |
Pituitary tumour benign | 48.89 | 10.17 | 30 | 92765 | 851 | 34863285 |
Fall | 48.65 | 10.17 | 327 | 92468 | 202558 | 34661578 |
Tendon pain | 48.07 | 10.17 | 49 | 92746 | 2946 | 34861190 |
Myocardial infarction | 47.20 | 10.17 | 164 | 92631 | 120921 | 34743215 |
Blood pressure increased | 47.09 | 10.17 | 397 | 92398 | 87705 | 34776431 |
Insulin-like growth factor decreased | 47.08 | 10.17 | 20 | 92775 | 253 | 34863883 |
Anal inflammation | 44.97 | 10.17 | 33 | 92762 | 1267 | 34862869 |
Soft tissue mass | 44.89 | 10.17 | 30 | 92765 | 989 | 34863147 |
Tendon disorder | 44.27 | 10.17 | 46 | 92749 | 2829 | 34861307 |
Eczema | 44.04 | 10.17 | 128 | 92667 | 18308 | 34845828 |
Acute kidney injury | 43.90 | 10.17 | 559 | 92236 | 304429 | 34559707 |
Gingival disorder | 43.17 | 10.17 | 34 | 92761 | 1453 | 34862683 |
Septic shock | 42.89 | 10.17 | 332 | 92463 | 71502 | 34792634 |
Pseudostroke | 42.67 | 10.17 | 12 | 92783 | 36 | 34864100 |
Fistula | 42.63 | 10.17 | 70 | 92725 | 6770 | 34857366 |
Multimorbidity | 42.14 | 10.17 | 28 | 92767 | 914 | 34863222 |
Cardiac failure | 40.90 | 10.17 | 116 | 92679 | 91132 | 34773004 |
Suicide attempt | 40.50 | 10.17 | 27 | 92768 | 39089 | 34825047 |
Oesophageal perforation | 40.49 | 10.17 | 30 | 92765 | 1169 | 34862967 |
Therapeutic response shortened | 39.86 | 10.17 | 71 | 92724 | 7333 | 34856803 |
Sedation | 38.72 | 10.17 | 5 | 92790 | 21001 | 34843135 |
Anaemia | 38.03 | 10.17 | 416 | 92379 | 232919 | 34631217 |
Atrial fibrillation | 37.54 | 10.17 | 182 | 92613 | 122211 | 34741925 |
Insulin-like growth factor increased | 37.33 | 10.17 | 29 | 92766 | 1214 | 34862922 |
Anal fissure | 36.86 | 10.17 | 51 | 92744 | 4239 | 34859897 |
Weight increased | 36.19 | 10.17 | 392 | 92403 | 92641 | 34771495 |
Tendon rupture | 36.17 | 10.17 | 66 | 92729 | 6946 | 34857190 |
Hypophysitis | 35.96 | 10.17 | 37 | 92758 | 2249 | 34861887 |
Poor venous access | 34.98 | 10.17 | 55 | 92740 | 5128 | 34859008 |
Drug level decreased | 34.49 | 10.17 | 69 | 92726 | 7777 | 34856359 |
Hypertriglyceridaemia | 34.42 | 10.17 | 72 | 92723 | 8376 | 34855760 |
Flushing | 33.90 | 10.17 | 173 | 92622 | 32247 | 34831889 |
Colitis | 33.10 | 10.17 | 192 | 92603 | 37558 | 34826578 |
Superinfection | 32.99 | 10.17 | 37 | 92758 | 2482 | 34861654 |
Neoplasm recurrence | 32.88 | 10.17 | 35 | 92760 | 2214 | 34861922 |
Hypogonadism | 32.80 | 10.17 | 35 | 92760 | 2220 | 34861916 |
Anal fistula | 31.97 | 10.17 | 54 | 92741 | 5345 | 34858791 |
Erythema | 31.32 | 10.17 | 367 | 92428 | 88413 | 34775723 |
Growth retardation | 31.06 | 10.17 | 31 | 92764 | 1817 | 34862319 |
Pelvic abscess | 30.61 | 10.17 | 23 | 92772 | 916 | 34863220 |
Cardio-respiratory arrest | 30.50 | 10.17 | 63 | 92732 | 55210 | 34808926 |
Gastrointestinal haemorrhage | 30.47 | 10.17 | 126 | 92669 | 88351 | 34775785 |
Renal impairment | 29.87 | 10.17 | 139 | 92656 | 94374 | 34769762 |
Blood pressure diastolic decreased | 29.75 | 10.17 | 71 | 92724 | 9023 | 34855113 |
Epiphysiolysis | 29.51 | 10.17 | 11 | 92784 | 96 | 34864040 |
Secondary adrenocortical insufficiency | 29.13 | 10.17 | 27 | 92768 | 1443 | 34862693 |
Meningitis candida | 28.61 | 10.17 | 10 | 92785 | 71 | 34864065 |
Crohn's disease | 28.21 | 10.17 | 38 | 92757 | 3079 | 34861057 |
Hallucination | 27.33 | 10.17 | 60 | 92735 | 51438 | 34812698 |
Subdural haematoma | 27.32 | 10.17 | 10 | 92785 | 20411 | 34843725 |
Lichen planus | 27.20 | 10.17 | 22 | 92773 | 977 | 34863159 |
Oral disorder | 27.18 | 10.17 | 44 | 92751 | 4205 | 34859931 |
Dermatitis atopic | 27.16 | 10.17 | 50 | 92745 | 5297 | 34858839 |
Idiopathic intracranial hypertension | 27.01 | 10.17 | 19 | 92776 | 682 | 34863454 |
Chorioretinopathy | 26.87 | 10.17 | 26 | 92769 | 1467 | 34862669 |
Myelopathy | 26.60 | 10.17 | 33 | 92762 | 2464 | 34861672 |
Thyroxine free decreased | 26.54 | 10.17 | 14 | 92781 | 295 | 34863841 |
Hypertrophic cardiomyopathy | 26.38 | 10.17 | 23 | 92772 | 1134 | 34863002 |
Thermophobia | 26.36 | 10.17 | 9 | 92786 | 59 | 34864077 |
Thyrotoxic periodic paralysis | 25.98 | 10.17 | 11 | 92784 | 138 | 34863998 |
Pituitary haemorrhage | 25.95 | 10.17 | 12 | 92783 | 188 | 34863948 |
Angina pectoris | 25.87 | 10.17 | 27 | 92768 | 31336 | 34832800 |
Drug hypersensitivity | 25.84 | 10.17 | 327 | 92468 | 80202 | 34783934 |
Feeling cold | 25.54 | 10.17 | 74 | 92721 | 10565 | 34853571 |
Respiratory disorder | 25.41 | 10.17 | 110 | 92685 | 19154 | 34844982 |
Neuroleptic malignant syndrome | 25.35 | 10.17 | 8 | 92787 | 17926 | 34846210 |
Renal failure | 24.89 | 10.17 | 224 | 92571 | 130333 | 34733803 |
Rash erythematous | 24.53 | 10.17 | 131 | 92664 | 24846 | 34839290 |
Abdominal pain | 24.27 | 10.17 | 587 | 92208 | 163031 | 34701105 |
Electrocardiogram QT prolonged | 24.04 | 10.17 | 45 | 92750 | 40907 | 34823229 |
Platelet count decreased | 23.88 | 10.17 | 203 | 92592 | 119514 | 34744622 |
Posterior reversible encephalopathy syndrome | 23.66 | 10.17 | 69 | 92726 | 9885 | 34854251 |
Meningitis tuberculous | 22.82 | 10.17 | 17 | 92778 | 668 | 34863468 |
Perioral dermatitis | 22.76 | 10.17 | 10 | 92785 | 138 | 34863998 |
Drug ineffective | 22.74 | 10.17 | 1453 | 91342 | 455298 | 34408838 |
SARS-CoV-2 test negative | 22.70 | 10.17 | 20 | 92775 | 1000 | 34863136 |
Chills | 22.65 | 10.17 | 321 | 92474 | 80722 | 34783414 |
Blood growth hormone decreased | 22.43 | 10.17 | 7 | 92788 | 33 | 34864103 |
Disease progression | 22.13 | 10.17 | 182 | 92613 | 107895 | 34756241 |
Adrenocorticotropic hormone deficiency | 21.95 | 10.17 | 19 | 92776 | 928 | 34863208 |
Shared psychotic disorder | 21.85 | 10.17 | 6 | 92789 | 16 | 34864120 |
Anal abscess | 21.67 | 10.17 | 51 | 92744 | 6422 | 34857714 |
Transplant failure | 21.66 | 10.17 | 36 | 92759 | 3517 | 34860619 |
Extrapyramidal disorder | 21.61 | 10.17 | 4 | 92791 | 12876 | 34851260 |
Hyperkalaemia | 21.36 | 10.17 | 103 | 92692 | 69286 | 34794850 |
Weight fluctuation | 20.90 | 10.17 | 44 | 92751 | 5141 | 34858995 |
Blood creatine phosphokinase increased | 20.85 | 10.17 | 56 | 92739 | 44801 | 34819335 |
Device dislocation | 20.67 | 10.17 | 49 | 92746 | 6200 | 34857936 |
Lactic acidosis | 20.60 | 10.17 | 38 | 92757 | 34734 | 34829402 |
Aggression | 20.18 | 10.17 | 46 | 92749 | 38918 | 34825218 |
Respiratory depression | 20.03 | 10.17 | 9 | 92786 | 16236 | 34847900 |
Strongyloidiasis | 20.03 | 10.17 | 30 | 92765 | 2681 | 34861455 |
Weight decreased | 20.02 | 10.17 | 611 | 92184 | 175690 | 34688446 |
Musculoskeletal injury | 19.99 | 10.17 | 9 | 92786 | 132 | 34864004 |
Coronary artery disease | 19.78 | 10.17 | 64 | 92731 | 48241 | 34815895 |
Intentional self-injury | 19.72 | 10.17 | 6 | 92789 | 13765 | 34850371 |
Pneumoretroperitoneum | 19.64 | 10.17 | 9 | 92786 | 138 | 34863998 |
Symptom masked | 19.43 | 10.17 | 15 | 92780 | 622 | 34863514 |
Transient ischaemic attack | 19.35 | 10.17 | 27 | 92768 | 27586 | 34836550 |
Gastrointestinal inflammation | 19.33 | 10.17 | 34 | 92761 | 3477 | 34860659 |
Cholangitis infective | 19.31 | 10.17 | 11 | 92784 | 271 | 34863865 |
Body temperature decreased | 19.21 | 10.17 | 77 | 92718 | 12957 | 34851179 |
Stevens-Johnson syndrome | 19.16 | 10.17 | 99 | 92696 | 18540 | 34845596 |
Periorbital infection | 19.07 | 10.17 | 9 | 92786 | 148 | 34863988 |
Coma | 19.06 | 10.17 | 60 | 92735 | 45618 | 34818518 |
Haematochezia | 18.98 | 10.17 | 198 | 92597 | 46336 | 34817800 |
Intentional product misuse | 18.97 | 10.17 | 60 | 92735 | 45551 | 34818585 |
Skin irritation | 18.74 | 10.17 | 44 | 92751 | 5533 | 34858603 |
Optic nerve disorder | 18.72 | 10.17 | 15 | 92780 | 657 | 34863479 |
Strabismus | 18.64 | 10.17 | 23 | 92772 | 1708 | 34862428 |
Cushingoid | 18.59 | 10.17 | 29 | 92766 | 2685 | 34861451 |
Blood growth hormone increased | 18.50 | 10.17 | 12 | 92783 | 376 | 34863760 |
Immunosuppressant drug level increased | 18.45 | 10.17 | 46 | 92749 | 6009 | 34858127 |
Intestinal intraepithelial lymphocytes increased | 18.39 | 10.17 | 9 | 92786 | 161 | 34863975 |
Hospitalisation | 18.38 | 10.17 | 83 | 92712 | 56819 | 34807317 |
Pyrexia | 18.32 | 10.17 | 1069 | 91726 | 331944 | 34532192 |
Haemorrhoids | 18.29 | 10.17 | 82 | 92713 | 14493 | 34849643 |
Depressed level of consciousness | 18.07 | 10.17 | 56 | 92739 | 42785 | 34821351 |
Tooth injury | 18.05 | 10.17 | 19 | 92776 | 1186 | 34862950 |
Bronchial haemorrhage | 18.02 | 10.17 | 15 | 92780 | 694 | 34863442 |
Pruritus | 18.01 | 10.17 | 499 | 92296 | 141482 | 34722654 |
Chronic kidney disease | 18.00 | 10.17 | 53 | 92742 | 41157 | 34822979 |
Syncope | 17.82 | 10.17 | 156 | 92639 | 91295 | 34772841 |
Rhabdomyolysis | 17.76 | 10.17 | 107 | 92688 | 68056 | 34796080 |
Candida infection | 17.46 | 10.17 | 93 | 92702 | 17622 | 34846514 |
Astrocytoma | 17.40 | 10.17 | 9 | 92786 | 182 | 34863954 |
Bradycardia | 17.32 | 10.17 | 123 | 92672 | 75295 | 34788841 |
Inflammatory marker increased | 17.25 | 10.17 | 40 | 92755 | 4988 | 34859148 |
White blood cell count decreased | 17.21 | 10.17 | 166 | 92629 | 95279 | 34768857 |
Body temperature increased | 16.99 | 10.17 | 91 | 92704 | 17277 | 34846859 |
Splenic peliosis | 16.88 | 10.17 | 5 | 92790 | 19 | 34864117 |
Stress | 16.86 | 10.17 | 138 | 92657 | 30209 | 34833927 |
Glioma | 16.58 | 10.17 | 11 | 92784 | 358 | 34863778 |
Klebsiella infection | 16.46 | 10.17 | 55 | 92740 | 8476 | 34855660 |
Pituitary tumour | 16.45 | 10.17 | 13 | 92782 | 558 | 34863578 |
Pouchitis | 16.29 | 10.17 | 14 | 92781 | 677 | 34863459 |
Vestibular neuronitis | 16.28 | 10.17 | 9 | 92786 | 209 | 34863927 |
Cardiac failure congestive | 16.24 | 10.17 | 142 | 92653 | 83128 | 34781008 |
Blood pressure diastolic increased | 16.18 | 10.17 | 39 | 92756 | 4986 | 34859150 |
Pharyngitis streptococcal | 16.10 | 10.17 | 27 | 92768 | 2657 | 34861479 |
Neuralgia | 16.04 | 10.17 | 81 | 92714 | 15032 | 34849104 |
Product quality issue | 16.02 | 10.17 | 13 | 92782 | 17022 | 34847114 |
Kounis syndrome | 16.00 | 10.17 | 26 | 92769 | 2492 | 34861644 |
Lung consolidation | 15.93 | 10.17 | 43 | 92752 | 5893 | 34858243 |
Accidental exposure to product | 15.93 | 10.17 | 7 | 92788 | 12795 | 34851341 |
Cryptococcal fungaemia | 15.84 | 10.17 | 7 | 92788 | 98 | 34864038 |
Pituitary tumour recurrent | 15.84 | 10.17 | 7 | 92788 | 98 | 34864038 |
Clostridium difficile infection | 15.84 | 10.17 | 95 | 92700 | 18803 | 34845333 |
Mantle cell lymphoma stage III | 15.78 | 10.17 | 5 | 92790 | 25 | 34864111 |
Lacrimal duct neoplasm | 15.78 | 10.17 | 5 | 92790 | 25 | 34864111 |
Hyperbilirubinaemia | 15.64 | 10.17 | 87 | 92708 | 16756 | 34847380 |
Cryptitis | 15.61 | 10.17 | 9 | 92786 | 227 | 34863909 |
Otitis media acute | 15.61 | 10.17 | 13 | 92782 | 602 | 34863534 |
Delirium | 15.54 | 10.17 | 62 | 92733 | 43929 | 34820207 |
Malignant neoplasm progression | 15.51 | 10.17 | 154 | 92641 | 87892 | 34776244 |
Body height below normal | 15.40 | 10.17 | 9 | 92786 | 233 | 34863903 |
Aphthous ulcer | 15.27 | 10.17 | 38 | 92757 | 4957 | 34859179 |
Diarrhoea haemorrhagic | 15.23 | 10.17 | 46 | 92749 | 6718 | 34857418 |
Perineal infection | 15.17 | 10.17 | 13 | 92782 | 626 | 34863510 |
Hydrocephalus | 15.16 | 10.17 | 39 | 92756 | 5193 | 34858943 |
Melaena | 15.10 | 10.17 | 46 | 92749 | 35334 | 34828802 |
Blood thyroid stimulating hormone decreased | 15.09 | 10.17 | 22 | 92773 | 1919 | 34862217 |
Posturing | 15.05 | 10.17 | 12 | 92783 | 522 | 34863614 |
Eczema herpeticum | 14.98 | 10.17 | 8 | 92787 | 173 | 34863963 |
Anaplastic astrocytoma | 14.95 | 10.17 | 7 | 92788 | 113 | 34864023 |
Scrotal infection | 14.93 | 10.17 | 13 | 92782 | 640 | 34863496 |
Proctalgia | 14.90 | 10.17 | 41 | 92754 | 5682 | 34858454 |
Blood pressure systolic increased | 14.76 | 10.17 | 108 | 92687 | 22844 | 34841292 |
Gastrointestinal anastomotic leak | 14.75 | 10.17 | 11 | 92784 | 433 | 34863703 |
Bladder cancer | 14.60 | 10.17 | 13 | 92782 | 16265 | 34847871 |
Back pain | 14.60 | 10.17 | 425 | 92370 | 121364 | 34742772 |
Impaired work ability | 14.56 | 10.17 | 46 | 92749 | 6884 | 34857252 |
Cerebral infarction | 14.55 | 10.17 | 32 | 92763 | 27423 | 34836713 |
Sepsis | 14.55 | 10.17 | 560 | 92235 | 166001 | 34698135 |
Wrong technique in product usage process | 14.51 | 10.17 | 48 | 92747 | 35938 | 34828198 |
Shunt malfunction | 14.46 | 10.17 | 8 | 92787 | 186 | 34863950 |
Rectal haemorrhage | 14.45 | 10.17 | 167 | 92628 | 40082 | 34824054 |
Skin exfoliation | 14.31 | 10.17 | 123 | 92672 | 27309 | 34836827 |
Disseminated cryptococcosis | 14.26 | 10.17 | 18 | 92777 | 1368 | 34862768 |
Microvillous inclusion disease | 14.23 | 10.17 | 8 | 92787 | 192 | 34863944 |
Congenital cardiovascular anomaly | 14.23 | 10.17 | 8 | 92787 | 192 | 34863944 |
Addison's disease | 14.22 | 10.17 | 4 | 92791 | 12 | 34864124 |
Pneumonia | 14.17 | 10.17 | 803 | 91992 | 361824 | 34502312 |
Renal disorder | 14.09 | 10.17 | 29 | 92766 | 25451 | 34838685 |
Pulmonary arterial hypertension | 14.06 | 10.17 | 3 | 92792 | 8736 | 34855400 |
Dyspnoea exertional | 14.05 | 10.17 | 63 | 92732 | 43216 | 34820920 |
Perineal pain | 14.05 | 10.17 | 14 | 92781 | 819 | 34863317 |
Cryptococcal meningoencephalitis | 13.97 | 10.17 | 7 | 92788 | 132 | 34864004 |
Probiotic therapy | 13.92 | 10.17 | 7 | 92788 | 133 | 34864003 |
Anaphylactic reaction | 13.91 | 10.17 | 139 | 92656 | 32162 | 34831974 |
Dermatitis diaper | 13.79 | 10.17 | 9 | 92786 | 285 | 34863851 |
Optic nerve operation | 13.79 | 10.17 | 11 | 92784 | 479 | 34863657 |
Abscess | 13.73 | 10.17 | 65 | 92730 | 11752 | 34852384 |
Suicidal ideation | 13.59 | 10.17 | 58 | 92737 | 40330 | 34823806 |
Lip swelling | 13.58 | 10.17 | 81 | 92714 | 15999 | 34848137 |
Glioblastoma multiforme | 13.56 | 10.17 | 13 | 92782 | 725 | 34863411 |
Prothrombin level abnormal | 13.45 | 10.17 | 6 | 92789 | 86 | 34864050 |
Cardiac disorder | 13.28 | 10.17 | 64 | 92731 | 43062 | 34821074 |
Blood creatinine increased | 13.26 | 10.17 | 175 | 92620 | 94801 | 34769335 |
Leukopenia | 13.24 | 10.17 | 105 | 92690 | 62751 | 34801385 |
Short stature | 13.03 | 10.17 | 6 | 92789 | 93 | 34864043 |
Hepatic function abnormal | 12.99 | 10.17 | 67 | 92728 | 44296 | 34819840 |
Apnoeic attack | 12.93 | 10.17 | 10 | 92785 | 416 | 34863720 |
Cerebrospinal fluid leakage | 12.92 | 10.17 | 11 | 92784 | 525 | 34863611 |
Perirectal abscess | 12.84 | 10.17 | 19 | 92776 | 1679 | 34862457 |
Product dose omission issue | 12.83 | 10.17 | 232 | 92563 | 119479 | 34744657 |
Functional gastrointestinal disorder | 12.80 | 10.17 | 22 | 92773 | 2209 | 34861927 |
Adrenal insufficiency neonatal | 12.73 | 10.17 | 3 | 92792 | 3 | 34864133 |
Administration site bruise | 12.73 | 10.17 | 3 | 92792 | 3 | 34864133 |
Stress at work | 12.73 | 10.17 | 8 | 92787 | 237 | 34863899 |
Blood corticotrophin increased | 12.70 | 10.17 | 6 | 92789 | 99 | 34864037 |
Rectal abscess | 12.68 | 10.17 | 17 | 92778 | 1371 | 34862765 |
Rash | 12.59 | 10.17 | 717 | 92078 | 222035 | 34642101 |
Urticaria | 12.54 | 10.17 | 234 | 92561 | 62143 | 34801993 |
Serotonin syndrome | 12.51 | 10.17 | 21 | 92774 | 19912 | 34844224 |
Cerebral haemorrhage | 12.49 | 10.17 | 49 | 92746 | 34888 | 34829248 |
Pharyngeal paraesthesia | 12.46 | 10.17 | 12 | 92783 | 673 | 34863463 |
General physical health deterioration | 12.39 | 10.17 | 253 | 92542 | 128016 | 34736120 |
Feeling hot | 12.37 | 10.17 | 91 | 92704 | 19281 | 34844855 |
Multiple organ dysfunction syndrome | 12.35 | 10.17 | 278 | 92517 | 76288 | 34787848 |
Gram stain positive | 12.33 | 10.17 | 6 | 92789 | 106 | 34864030 |
Heart rate increased | 12.32 | 10.17 | 182 | 92613 | 46161 | 34817975 |
Neurotoxicity | 12.31 | 10.17 | 86 | 92709 | 17924 | 34846212 |
Lung neoplasm malignant | 12.19 | 10.17 | 17 | 92778 | 17378 | 34846758 |
Phaeochromocytoma crisis | 12.16 | 10.17 | 5 | 92790 | 58 | 34864078 |
Anorectal disorder | 12.12 | 10.17 | 15 | 92780 | 1117 | 34863019 |
Prostate cancer | 12.11 | 10.17 | 59 | 92736 | 39590 | 34824546 |
Cardiac failure chronic | 12.09 | 10.17 | 3 | 92792 | 7876 | 34856260 |
Foetal exposure during pregnancy | 12.05 | 10.17 | 56 | 92739 | 38045 | 34826091 |
Blood glucose increased | 12.04 | 10.17 | 116 | 92679 | 66602 | 34797534 |
Myelitis transverse | 12.04 | 10.17 | 15 | 92780 | 1125 | 34863011 |
Liver disorder | 11.98 | 10.17 | 46 | 92749 | 32951 | 34831185 |
Short-bowel syndrome | 11.94 | 10.17 | 8 | 92787 | 265 | 34863871 |
Blood luteinising hormone decreased | 11.93 | 10.17 | 6 | 92789 | 114 | 34864022 |
Incorrect dose administered | 11.93 | 10.17 | 162 | 92633 | 40353 | 34823783 |
Neutrophil count decreased | 11.90 | 10.17 | 83 | 92712 | 51021 | 34813115 |
Pharyngitis bacterial | 11.86 | 10.17 | 5 | 92790 | 62 | 34864074 |
Trichosporon infection | 11.76 | 10.17 | 12 | 92783 | 722 | 34863414 |
Agranulocytosis | 11.63 | 10.17 | 29 | 92766 | 23792 | 34840344 |
Pallor | 11.63 | 10.17 | 111 | 92684 | 25369 | 34838767 |
Hypernatraemia | 11.60 | 10.17 | 49 | 92746 | 8441 | 34855695 |
Drug level above therapeutic | 11.57 | 10.17 | 31 | 92764 | 4230 | 34859906 |
Coordination abnormal | 11.56 | 10.17 | 3 | 92792 | 7641 | 34856495 |
Skin warm | 11.53 | 10.17 | 21 | 92774 | 2206 | 34861930 |
Congenital adrenal gland hypoplasia | 11.52 | 10.17 | 3 | 92792 | 6 | 34864130 |
Dermal cyst | 11.49 | 10.17 | 19 | 92776 | 1848 | 34862288 |
Infected dermal cyst | 11.48 | 10.17 | 13 | 92782 | 881 | 34863255 |
Tracheobronchitis | 11.48 | 10.17 | 14 | 92781 | 1027 | 34863109 |
Full blood count abnormal | 11.41 | 10.17 | 20 | 92775 | 18648 | 34845488 |
Potentiating drug interaction | 11.35 | 10.17 | 34 | 92761 | 4943 | 34859193 |
Dry skin | 11.31 | 10.17 | 130 | 92665 | 31157 | 34832979 |
Toxic epidermal necrolysis | 11.26 | 10.17 | 97 | 92698 | 21549 | 34842587 |
Unmasking of previously unidentified disease | 11.25 | 10.17 | 13 | 92782 | 901 | 34863235 |
Rales | 11.22 | 10.17 | 54 | 92741 | 9829 | 34854307 |
Chronic sinusitis | 11.19 | 10.17 | 21 | 92774 | 2258 | 34861878 |
Mean cell volume decreased | 11.18 | 10.17 | 16 | 92779 | 1372 | 34862764 |
Lichenification | 11.18 | 10.17 | 9 | 92786 | 397 | 34863739 |
Morganella infection | 11.15 | 10.17 | 10 | 92785 | 512 | 34863624 |
Blood corticotrophin decreased | 11.15 | 10.17 | 7 | 92788 | 207 | 34863929 |
Arm amputation | 11.14 | 10.17 | 6 | 92789 | 132 | 34864004 |
Haemoglobin decreased | 11.14 | 10.17 | 240 | 92555 | 120532 | 34743604 |
Skin papilloma | 11.11 | 10.17 | 20 | 92775 | 2083 | 34862053 |
Apoptosis | 11.08 | 10.17 | 9 | 92786 | 402 | 34863734 |
Antibody test abnormal | 11.03 | 10.17 | 7 | 92788 | 211 | 34863925 |
Psychotic disorder | 11.01 | 10.17 | 31 | 92764 | 24421 | 34839715 |
Thyroxine decreased | 11 | 10.17 | 7 | 92788 | 212 | 34863924 |
Contraindicated product prescribed | 10.97 | 10.17 | 9 | 92786 | 408 | 34863728 |
Biopsy | 10.95 | 10.17 | 8 | 92787 | 305 | 34863831 |
Gonadotrophin deficiency | 10.93 | 10.17 | 4 | 92791 | 33 | 34864103 |
Leptotrichia infection | 10.83 | 10.17 | 5 | 92790 | 78 | 34864058 |
Cortisol abnormal | 10.82 | 10.17 | 4 | 92791 | 34 | 34864102 |
Mental fatigue | 10.71 | 10.17 | 6 | 92789 | 143 | 34863993 |
Metabolic acidosis | 10.64 | 10.17 | 70 | 92725 | 43610 | 34820526 |
Type 1 diabetes mellitus | 10.59 | 10.17 | 30 | 92765 | 4228 | 34859908 |
Loss of consciousness | 10.58 | 10.17 | 155 | 92640 | 82512 | 34781624 |
Pulmonary artery dilatation | 10.55 | 10.17 | 7 | 92788 | 228 | 34863908 |
Hypothalamo-pituitary disorder | 10.54 | 10.17 | 12 | 92783 | 818 | 34863318 |
Anal haemorrhage | 10.54 | 10.17 | 22 | 92773 | 2556 | 34861580 |
Hypothyroidism | 10.53 | 10.17 | 93 | 92702 | 20809 | 34843327 |
Defaecation urgency | 10.47 | 10.17 | 22 | 92773 | 2567 | 34861569 |
Haematemesis | 10.47 | 10.17 | 38 | 92757 | 27673 | 34836463 |
Diplegia | 10.30 | 10.17 | 13 | 92782 | 988 | 34863148 |
Delusion | 10.28 | 10.17 | 11 | 92784 | 12624 | 34851512 |
Blood culture positive | 10.28 | 10.17 | 32 | 92763 | 4751 | 34859385 |
Hypersensitivity | 10.28 | 10.17 | 223 | 92572 | 60812 | 34803324 |
Unevaluable event | 10.24 | 10.17 | 48 | 92747 | 32542 | 34831594 |
Liver function test abnormal | 10.23 | 10.17 | 45 | 92750 | 31029 | 34833107 |
Dizziness | 10.21 | 10.17 | 475 | 92320 | 218046 | 34646090 |
Necrotising bronchiolitis | 10.21 | 10.17 | 3 | 92792 | 11 | 34864125 |
Job dissatisfaction | 10.21 | 10.17 | 6 | 92789 | 157 | 34863979 |
Skin lesion | 10.19 | 10.17 | 96 | 92699 | 21865 | 34842271 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 683.46 | 9.47 | 21 | 252810 | 245746 | 79245811 |
Intentional product use issue | 648.06 | 9.47 | 1466 | 251365 | 150646 | 79340911 |
Toxicity to various agents | 558.25 | 9.47 | 322 | 252509 | 421218 | 79070339 |
Infusion related reaction | 541.48 | 9.47 | 1783 | 251048 | 228454 | 79263103 |
Pericarditis | 449.72 | 9.47 | 1010 | 251821 | 103226 | 79388331 |
Drug abuse | 448.25 | 9.47 | 15 | 252816 | 162676 | 79328881 |
Wound | 446.79 | 9.47 | 1076 | 251755 | 115103 | 79376454 |
Anti-cyclic citrullinated peptide antibody positive | 441.55 | 9.47 | 877 | 251954 | 82266 | 79409291 |
Glossodynia | 433.26 | 9.47 | 990 | 251841 | 102347 | 79389210 |
Duodenal ulcer perforation | 428.32 | 9.47 | 760 | 252071 | 65451 | 79426106 |
Systemic lupus erythematosus | 412.28 | 9.47 | 1071 | 251760 | 120078 | 79371479 |
Pemphigus | 411.93 | 9.47 | 949 | 251882 | 98633 | 79392924 |
Helicobacter infection | 404.02 | 9.47 | 763 | 252068 | 68941 | 79422616 |
Hand deformity | 386.25 | 9.47 | 950 | 251881 | 102969 | 79388588 |
Discomfort | 365.05 | 9.47 | 1048 | 251783 | 124569 | 79366988 |
Adrenocortical insufficiency acute | 353.50 | 9.47 | 179 | 252652 | 2864 | 79488693 |
Rheumatoid factor positive | 346.75 | 9.47 | 655 | 252176 | 59184 | 79432373 |
Death | 335.87 | 9.47 | 819 | 252012 | 565695 | 78925862 |
Inappropriate schedule of product administration | 314.77 | 9.47 | 1036 | 251795 | 132592 | 79358965 |
Blood pressure fluctuation | 297.80 | 9.47 | 658 | 252173 | 66487 | 79425070 |
Adrenal insufficiency | 282.78 | 9.47 | 398 | 252433 | 28089 | 79463468 |
Blister | 270.44 | 9.47 | 914 | 251917 | 118562 | 79372995 |
Synovitis | 267.80 | 9.47 | 1066 | 251765 | 149668 | 79341889 |
Rheumatic fever | 258.97 | 9.47 | 382 | 252449 | 28143 | 79463414 |
Drug interaction | 247.53 | 9.47 | 598 | 252233 | 414585 | 79076972 |
Off label use | 245.39 | 9.47 | 4135 | 248696 | 903080 | 78588477 |
Arthropathy | 237.31 | 9.47 | 1151 | 251680 | 175960 | 79315597 |
Condition aggravated | 234.34 | 9.47 | 2523 | 250308 | 498601 | 78992956 |
Product use issue | 230.31 | 9.47 | 1290 | 251541 | 208532 | 79283025 |
Alopecia | 222.07 | 9.47 | 1373 | 251458 | 229982 | 79261575 |
Swelling | 220 | 9.47 | 1305 | 251526 | 215406 | 79276151 |
Irritable bowel syndrome | 213.39 | 9.47 | 552 | 252279 | 61689 | 79429868 |
Folliculitis | 209.62 | 9.47 | 510 | 252321 | 54870 | 79436687 |
Intentional overdose | 208.88 | 9.47 | 41 | 252790 | 105919 | 79385638 |
Fall | 203.92 | 9.47 | 825 | 252006 | 486804 | 79004753 |
Overdose | 200.88 | 9.47 | 173 | 252658 | 184033 | 79307524 |
Colitis ulcerative | 200.86 | 9.47 | 380 | 252451 | 34362 | 79457195 |
Abdominal discomfort | 200.69 | 9.47 | 1422 | 251409 | 249305 | 79242252 |
Hepatic enzyme increased | 200.56 | 9.47 | 1123 | 251708 | 181487 | 79310070 |
Hypersensitivity | 200.52 | 9.47 | 1471 | 251360 | 260768 | 79230789 |
Craniopharyngioma | 192.17 | 9.47 | 65 | 252766 | 335 | 79491222 |
Maternal exposure during pregnancy | 189.84 | 9.47 | 897 | 251934 | 135641 | 79355916 |
Swollen joint count increased | 189.61 | 9.47 | 294 | 252537 | 22633 | 79468924 |
Acute kidney injury | 181.85 | 9.47 | 938 | 251893 | 518466 | 78973091 |
Muscle injury | 177.20 | 9.47 | 441 | 252390 | 48120 | 79443437 |
Steroid withdrawal syndrome | 154.89 | 9.47 | 65 | 252766 | 656 | 79490901 |
Blood cholesterol increased | 153.36 | 9.47 | 598 | 252233 | 83122 | 79408435 |
Frequent bowel movements | 150.04 | 9.47 | 306 | 252525 | 29233 | 79462324 |
Sleep disorder due to general medical condition, insomnia type | 147.96 | 9.47 | 385 | 252446 | 43171 | 79448386 |
Type 2 diabetes mellitus | 144.49 | 9.47 | 454 | 252377 | 56668 | 79434889 |
Drug level below therapeutic | 142.01 | 9.47 | 165 | 252666 | 9605 | 79481952 |
Hip arthroplasty | 139.28 | 9.47 | 333 | 252498 | 35423 | 79456134 |
Fibromyalgia | 133.17 | 9.47 | 478 | 252353 | 63862 | 79427695 |
Interstitial lung disease | 132.44 | 9.47 | 98 | 252733 | 112502 | 79379055 |
Drug intolerance | 130.72 | 9.47 | 1346 | 251485 | 262773 | 79228784 |
Secondary immunodeficiency | 128.99 | 9.47 | 96 | 252735 | 3138 | 79488419 |
Injury | 127.96 | 9.47 | 536 | 252295 | 76960 | 79414597 |
Anaemia | 126.27 | 9.47 | 859 | 251972 | 444156 | 79047401 |
Weight increased | 126.25 | 9.47 | 1390 | 251441 | 275996 | 79215561 |
Drug hypersensitivity | 114.85 | 9.47 | 1450 | 251381 | 297466 | 79194091 |
Suicide attempt | 112.90 | 9.47 | 61 | 252770 | 82871 | 79408686 |
Faecal calprotectin increased | 111.21 | 9.47 | 111 | 252720 | 5430 | 79486127 |
Impaired healing | 109.72 | 9.47 | 559 | 252272 | 87096 | 79404461 |
Rash | 109.16 | 9.47 | 2499 | 250332 | 575859 | 78915698 |
Myocardial infarction | 108.11 | 9.47 | 267 | 252564 | 183862 | 79307695 |
Deep vein thrombosis postoperative | 107.85 | 9.47 | 151 | 252680 | 10601 | 79480956 |
Sedation | 104.56 | 9.47 | 19 | 252812 | 51876 | 79439681 |
Atrial fibrillation | 99.75 | 9.47 | 309 | 252522 | 197577 | 79293980 |
Lip dry | 98.38 | 9.47 | 176 | 252655 | 15242 | 79476315 |
Heart rate irregular | 98.09 | 9.47 | 276 | 252555 | 32403 | 79459154 |
Facet joint syndrome | 97.77 | 9.47 | 148 | 252683 | 11154 | 79480403 |
Liver injury | 97.72 | 9.47 | 397 | 252434 | 56217 | 79435340 |
Psoriatic arthropathy | 96.63 | 9.47 | 496 | 252335 | 77503 | 79414054 |
Contraindicated product administered | 95.33 | 9.47 | 838 | 251993 | 156700 | 79334857 |
Lower respiratory tract infection | 94.72 | 9.47 | 718 | 252113 | 128502 | 79363055 |
Cardio-respiratory arrest | 91.57 | 9.47 | 126 | 252705 | 108384 | 79383173 |
Coma | 90.98 | 9.47 | 111 | 252720 | 100538 | 79391019 |
Pituitary tumour benign | 90.72 | 9.47 | 71 | 252760 | 2505 | 79489052 |
Cardiac failure | 90.52 | 9.47 | 225 | 252606 | 154617 | 79336940 |
Gastrointestinal haemorrhage | 89.24 | 9.47 | 211 | 252620 | 147508 | 79344049 |
Knee arthroplasty | 88.38 | 9.47 | 320 | 252511 | 42928 | 79448629 |
Renal impairment | 86.34 | 9.47 | 237 | 252594 | 157546 | 79334011 |
Autoimmune disorder | 85.44 | 9.47 | 173 | 252658 | 16439 | 79475118 |
Febrile bone marrow aplasia | 84.84 | 9.47 | 150 | 252681 | 12870 | 79478687 |
Body temperature fluctuation | 83.38 | 9.47 | 80 | 252751 | 3727 | 79487830 |
Hypopituitarism | 83.24 | 9.47 | 76 | 252755 | 3323 | 79488234 |
Syncope | 83.00 | 9.47 | 291 | 252540 | 179158 | 79312399 |
Heart rate decreased | 82.86 | 9.47 | 441 | 252390 | 69875 | 79421682 |
Therapeutic response shortened | 80.17 | 9.47 | 164 | 252667 | 15699 | 79475858 |
Anal fissure | 78.48 | 9.47 | 109 | 252722 | 7594 | 79483963 |
Aplastic anaemia | 77.69 | 9.47 | 174 | 252657 | 17731 | 79473826 |
Platelet count decreased | 77.65 | 9.47 | 335 | 252496 | 194329 | 79297228 |
Product dose omission issue | 77.16 | 9.47 | 464 | 252367 | 247073 | 79244484 |
Secondary adrenocortical insufficiency | 76.97 | 9.47 | 69 | 252762 | 2945 | 79488612 |
Live birth | 76.73 | 9.47 | 178 | 252653 | 18566 | 79472991 |
Peripheral venous disease | 76.32 | 9.47 | 161 | 252670 | 15748 | 79475809 |
Diabetes insipidus | 75.37 | 9.47 | 88 | 252743 | 5149 | 79486408 |
Cortisol decreased | 74.62 | 9.47 | 59 | 252772 | 2113 | 79489444 |
Therapeutic product effect decreased | 74.40 | 9.47 | 821 | 252010 | 163042 | 79328515 |
Poor venous access | 73.91 | 9.47 | 172 | 252659 | 17977 | 79473580 |
Depressed level of consciousness | 73.07 | 9.47 | 121 | 252710 | 96531 | 79395026 |
Stomatitis | 73.03 | 9.47 | 749 | 252082 | 146008 | 79345549 |
Intentional product misuse | 73.01 | 9.47 | 118 | 252713 | 95047 | 79396510 |
Arthralgia | 71.97 | 9.47 | 2345 | 250486 | 569458 | 78922099 |
Adjustment disorder with depressed mood | 71.64 | 9.47 | 114 | 252717 | 8972 | 79482585 |
Cardiac failure congestive | 70.59 | 9.47 | 224 | 252607 | 142178 | 79349379 |
Electrocardiogram QT prolonged | 70.35 | 9.47 | 111 | 252720 | 90275 | 79401282 |
Joint swelling | 70.03 | 9.47 | 1295 | 251536 | 287351 | 79204206 |
Bradycardia | 69.48 | 9.47 | 210 | 252621 | 135347 | 79356210 |
Fistula | 69.23 | 9.47 | 137 | 252694 | 12803 | 79478754 |
Steroid dependence | 68.73 | 9.47 | 61 | 252770 | 2569 | 79488988 |
Disease progression | 68.30 | 9.47 | 326 | 252505 | 184036 | 79307521 |
Respiratory arrest | 67.77 | 9.47 | 50 | 252781 | 57500 | 79434057 |
Leukoencephalopathy | 67.41 | 9.47 | 103 | 252728 | 7826 | 79483731 |
Human bocavirus infection | 67.17 | 9.47 | 37 | 252794 | 708 | 79490849 |
Pneumonia | 66.55 | 9.47 | 1590 | 251241 | 658656 | 78832901 |
Haemoglobin decreased | 66.28 | 9.47 | 422 | 252409 | 221697 | 79269860 |
Drug specific antibody present | 66.09 | 9.47 | 93 | 252738 | 6559 | 79484998 |
Mycobacterium chelonae infection | 64.26 | 9.47 | 57 | 252774 | 2399 | 79489158 |
Lactic acidosis | 64.21 | 9.47 | 77 | 252754 | 70282 | 79421275 |
Cognitive disorder | 63.31 | 9.47 | 77 | 252754 | 69849 | 79421708 |
Serotonin syndrome | 62.93 | 9.47 | 32 | 252799 | 44995 | 79446562 |
Full blood count abnormal | 62.45 | 9.47 | 25 | 252806 | 40449 | 79451108 |
Treatment failure | 62.42 | 9.47 | 820 | 252011 | 169666 | 79321891 |
Ill-defined disorder | 61.85 | 9.47 | 389 | 252442 | 65486 | 79426071 |
Hypofibrinogenaemia | 61.62 | 9.47 | 51 | 252780 | 1951 | 79489606 |
Bacterial infection | 61.01 | 9.47 | 228 | 252603 | 31052 | 79460505 |
Intentional self-injury | 60.89 | 9.47 | 14 | 252817 | 32405 | 79459152 |
Febrile neutropenia | 60.48 | 9.47 | 1049 | 251782 | 229950 | 79261607 |
White blood cell count decreased | 59.68 | 9.47 | 351 | 252480 | 187937 | 79303620 |
Blood creatine phosphokinase increased | 58.55 | 9.47 | 74 | 252757 | 66016 | 79425541 |
Blood creatinine increased | 58.12 | 9.47 | 273 | 252558 | 154784 | 79336773 |
Device expulsion | 57.78 | 9.47 | 7 | 252824 | 25854 | 79465703 |
Drug level decreased | 57.02 | 9.47 | 135 | 252696 | 14267 | 79477290 |
Anti-cyclic citrullinated peptide antibody | 56.94 | 9.47 | 81 | 252750 | 5771 | 79485786 |
Malignant neoplasm progression | 56.71 | 9.47 | 230 | 252601 | 135760 | 79355797 |
Neutropenia | 56.11 | 9.47 | 612 | 252219 | 287098 | 79204459 |
Neoplasm recurrence | 56.02 | 9.47 | 68 | 252763 | 4146 | 79487411 |
Prescribed overdose | 55.63 | 9.47 | 253 | 252578 | 37630 | 79453927 |
Leukopenia | 55.17 | 9.47 | 187 | 252644 | 116326 | 79375231 |
Pruritus | 53.64 | 9.47 | 1634 | 251197 | 393014 | 79098543 |
Neuroleptic malignant syndrome | 53.59 | 9.47 | 11 | 252820 | 27548 | 79464009 |
Melaena | 53.09 | 9.47 | 69 | 252762 | 60821 | 79430736 |
Exposure during pregnancy | 51.66 | 9.47 | 519 | 252312 | 100613 | 79390944 |
Renal failure | 51.52 | 9.47 | 399 | 252432 | 200569 | 79290988 |
Nasopharyngitis | 51.50 | 9.47 | 1109 | 251722 | 252772 | 79238785 |
Hepatic function abnormal | 50.33 | 9.47 | 97 | 252734 | 73010 | 79418547 |
Adrenal suppression | 50.22 | 9.47 | 39 | 252792 | 1360 | 79490197 |
Cerebrovascular accident | 50.00 | 9.47 | 288 | 252543 | 155004 | 79336553 |
Urticaria | 49.90 | 9.47 | 845 | 251986 | 184356 | 79307201 |
Adverse event | 49.52 | 9.47 | 344 | 252487 | 59870 | 79431687 |
Pseudostroke | 49.43 | 9.47 | 16 | 252815 | 70 | 79491487 |
Hyperkalaemia | 48.00 | 9.47 | 193 | 252638 | 114205 | 79377352 |
Dislocation of vertebra | 47.79 | 9.47 | 88 | 252743 | 7792 | 79483765 |
Eczema | 47.40 | 9.47 | 255 | 252576 | 40563 | 79450994 |
Norovirus test positive | 46.64 | 9.47 | 28 | 252803 | 634 | 79490923 |
Wrong technique in product usage process | 46.64 | 9.47 | 103 | 252728 | 73772 | 79417785 |
Breast cancer stage III | 46.63 | 9.47 | 99 | 252732 | 9727 | 79481830 |
Anal fistula | 46.54 | 9.47 | 81 | 252750 | 6863 | 79484694 |
Cardiac arrest | 46.33 | 9.47 | 337 | 252494 | 171759 | 79319798 |
Lower limb fracture | 45.93 | 9.47 | 170 | 252661 | 23045 | 79468512 |
Perioral dermatitis | 45.92 | 9.47 | 23 | 252808 | 359 | 79491198 |
Hypophysitis | 45.54 | 9.47 | 61 | 252770 | 4105 | 79487452 |
Gastrointestinal disorder | 45.23 | 9.47 | 589 | 252242 | 121616 | 79369941 |
Meningitis candida | 44.95 | 9.47 | 17 | 252814 | 127 | 79491430 |
Maternal exposure timing unspecified | 44.74 | 9.47 | 72 | 252759 | 5720 | 79485837 |
Wheezing | 44.74 | 9.47 | 566 | 252265 | 116098 | 79375459 |
Suicidal ideation | 44.54 | 9.47 | 111 | 252720 | 76229 | 79415328 |
Rhabdomyolysis | 44.53 | 9.47 | 172 | 252659 | 102959 | 79388598 |
Hepatotoxicity | 43.95 | 9.47 | 59 | 252772 | 51293 | 79440264 |
Hallucination | 43.81 | 9.47 | 133 | 252698 | 85612 | 79405945 |
Thrombocytopenia | 42.71 | 9.47 | 588 | 252243 | 264671 | 79226886 |
Nausea | 42.15 | 9.47 | 2546 | 250285 | 954650 | 78536907 |
Insulin-like growth factor decreased | 41.88 | 9.47 | 25 | 252806 | 560 | 79490997 |
Transient ischaemic attack | 41.68 | 9.47 | 64 | 252767 | 52631 | 79438926 |
Metabolic acidosis | 41.46 | 9.47 | 129 | 252702 | 82400 | 79409157 |
Thymus hypoplasia | 41.33 | 9.47 | 30 | 252801 | 943 | 79490614 |
Accidental exposure to product | 41.23 | 9.47 | 24 | 252807 | 31298 | 79460259 |
Insulin-like growth factor increased | 40.12 | 9.47 | 39 | 252792 | 1847 | 79489710 |
Joint range of motion decreased | 40.06 | 9.47 | 210 | 252621 | 33072 | 79458485 |
Adverse drug reaction | 40.04 | 9.47 | 353 | 252478 | 66039 | 79425518 |
Loss of consciousness | 40.03 | 9.47 | 340 | 252491 | 167603 | 79323954 |
Cystitis bacterial | 39.87 | 9.47 | 26 | 252805 | 684 | 79490873 |
Respiratory depression | 39.57 | 9.47 | 19 | 252812 | 27611 | 79463946 |
Female genital tract fistula | 39.14 | 9.47 | 69 | 252762 | 5906 | 79485651 |
Human herpesvirus 6 infection | 39.11 | 9.47 | 65 | 252766 | 5305 | 79486252 |
Balance disorder | 38.86 | 9.47 | 171 | 252660 | 98686 | 79392871 |
Contusion | 38.68 | 9.47 | 675 | 252156 | 148101 | 79343456 |
Somnolence | 38.37 | 9.47 | 530 | 252301 | 238451 | 79253106 |
Lymphoid tissue hypoplasia | 37.97 | 9.47 | 28 | 252803 | 902 | 79490655 |
Tendon pain | 37.92 | 9.47 | 66 | 252765 | 5592 | 79485965 |
Night sweats | 37.88 | 9.47 | 289 | 252542 | 51806 | 79439751 |
Poisoning deliberate | 37.70 | 9.47 | 7 | 252824 | 18821 | 79472736 |
Pseudomonal sepsis | 37.51 | 9.47 | 69 | 252762 | 6105 | 79485452 |
Orthostatic hypotension | 37.38 | 9.47 | 76 | 252755 | 56088 | 79435469 |
Anal inflammation | 37.04 | 9.47 | 33 | 252798 | 1397 | 79490160 |
Clostridium difficile colitis | 37.02 | 9.47 | 201 | 252630 | 32082 | 79459475 |
Hypotension | 36.99 | 9.47 | 1088 | 251743 | 439229 | 79052328 |
Extrapyramidal disorder | 36.68 | 9.47 | 13 | 252818 | 22666 | 79468891 |
Cardiac disorder | 36.53 | 9.47 | 98 | 252733 | 65659 | 79425898 |
Rhinovirus infection | 36.44 | 9.47 | 79 | 252752 | 7874 | 79483683 |
C-reactive protein | 35.90 | 9.47 | 60 | 252771 | 4919 | 79486638 |
Hypothalamo-pituitary disorder | 35.89 | 9.47 | 30 | 252801 | 1164 | 79490393 |
Haematuria | 35.72 | 9.47 | 106 | 252725 | 68730 | 79422827 |
Chronic kidney disease | 35.70 | 9.47 | 100 | 252731 | 66054 | 79425503 |
Musculoskeletal stiffness | 35.63 | 9.47 | 765 | 252066 | 174243 | 79317314 |
Pulmonary arterial hypertension | 35.58 | 9.47 | 23 | 252808 | 28343 | 79463214 |
Injection site erythema | 35.33 | 9.47 | 128 | 252703 | 78069 | 79413488 |
Parainfluenzae virus infection | 35.15 | 9.47 | 64 | 252767 | 5618 | 79485939 |
Strongyloidiasis | 35.08 | 9.47 | 52 | 252779 | 3846 | 79487711 |
Schizophrenia | 34.94 | 9.47 | 4 | 252827 | 15436 | 79476121 |
Subdural haematoma | 34.87 | 9.47 | 29 | 252802 | 31405 | 79460152 |
Drug level above therapeutic | 34.79 | 9.47 | 82 | 252749 | 8641 | 79482916 |
Myelosuppression | 34.78 | 9.47 | 46 | 252785 | 40250 | 79451307 |
Grip strength decreased | 34.33 | 9.47 | 149 | 252682 | 21720 | 79469837 |
Acute myocardial infarction | 34.22 | 9.47 | 127 | 252704 | 76909 | 79414648 |
Blood pressure increased | 33.63 | 9.47 | 893 | 251938 | 210467 | 79281090 |
Parkinsonism | 33.56 | 9.47 | 6 | 252825 | 16578 | 79474979 |
Coronary artery disease | 33.13 | 9.47 | 102 | 252729 | 65372 | 79426185 |
Anal abscess | 33.11 | 9.47 | 84 | 252747 | 9271 | 79482286 |
Hypogonadism | 33.03 | 9.47 | 34 | 252797 | 1726 | 79489831 |
X-ray abnormal | 32.87 | 9.47 | 63 | 252768 | 5750 | 79485807 |
Eczema herpeticum | 32.55 | 9.47 | 17 | 252814 | 291 | 79491266 |
Pituitary haemorrhage | 32.39 | 9.47 | 17 | 252814 | 294 | 79491263 |
Sciatica | 32.32 | 9.47 | 198 | 252633 | 33024 | 79458533 |
Septic shock | 32.22 | 9.47 | 558 | 252273 | 122243 | 79369314 |
Shared psychotic disorder | 32.21 | 9.47 | 10 | 252821 | 37 | 79491520 |
Agitation | 32.05 | 9.47 | 185 | 252646 | 99530 | 79392027 |
Soft tissue mass | 31.93 | 9.47 | 29 | 252802 | 1259 | 79490298 |
Bladder cancer | 31.91 | 9.47 | 11 | 252820 | 19515 | 79472042 |
Wound infection | 31.41 | 9.47 | 155 | 252676 | 23836 | 79467721 |
Bursitis | 31.39 | 9.47 | 208 | 252623 | 35636 | 79455921 |
Hospitalisation | 31.28 | 9.47 | 173 | 252658 | 94063 | 79397494 |
International normalised ratio increased | 31.24 | 9.47 | 150 | 252681 | 84571 | 79406986 |
Aspartate aminotransferase increased | 31.12 | 9.47 | 285 | 252546 | 138356 | 79353201 |
Chronic obstructive pulmonary disease | 31.06 | 9.47 | 152 | 252679 | 85267 | 79406290 |
Osteonecrosis of jaw | 30.94 | 9.47 | 56 | 252775 | 43170 | 79448387 |
Liver function test abnormal | 30.84 | 9.47 | 103 | 252728 | 64372 | 79427185 |
Unevaluable event | 30.75 | 9.47 | 83 | 252748 | 55502 | 79436055 |
Arrhythmia | 30.62 | 9.47 | 96 | 252735 | 61176 | 79430381 |
Perfume sensitivity | 30.46 | 9.47 | 24 | 252807 | 855 | 79490702 |
Pituitary tumour recurrent | 30.44 | 9.47 | 14 | 252817 | 179 | 79491378 |
Alanine aminotransferase increased | 30.40 | 9.47 | 349 | 252482 | 162221 | 79329336 |
Hyperadrenocorticism | 30.19 | 9.47 | 17 | 252814 | 340 | 79491217 |
Hypercalcaemia | 30.08 | 9.47 | 47 | 252784 | 38383 | 79453174 |
Aggression | 29.80 | 9.47 | 74 | 252757 | 50884 | 79440673 |
Proctalgia | 29.55 | 9.47 | 84 | 252747 | 9917 | 79481640 |
Injection site swelling | 29.51 | 9.47 | 66 | 252765 | 47066 | 79444491 |
Lupus vulgaris | 29.20 | 9.47 | 44 | 252787 | 3302 | 79488255 |
Cerebral haemorrhage | 29.07 | 9.47 | 90 | 252741 | 57583 | 79433974 |
Incorrect dose administered | 29.04 | 9.47 | 371 | 252460 | 76259 | 79415298 |
Impaired quality of life | 29.01 | 9.47 | 106 | 252725 | 14280 | 79477277 |
Road traffic accident | 28.88 | 9.47 | 237 | 252594 | 43427 | 79448130 |
Breast cancer | 28.71 | 9.47 | 39 | 252792 | 33742 | 79457815 |
Fluid retention | 28.51 | 9.47 | 119 | 252712 | 69690 | 79421867 |
Neutrophil count decreased | 28.26 | 9.47 | 178 | 252653 | 93781 | 79397776 |
Mucosal inflammation | 28.26 | 9.47 | 365 | 252466 | 75215 | 79416342 |
Colitis | 28.24 | 9.47 | 356 | 252475 | 72951 | 79418606 |
Angina pectoris | 28.06 | 9.47 | 78 | 252753 | 51654 | 79439903 |
Product prescribing error | 27.86 | 9.47 | 63 | 252768 | 44750 | 79446807 |
Injection site pain | 27.82 | 9.47 | 270 | 252561 | 129568 | 79361989 |
Infection | 27.44 | 9.47 | 980 | 251851 | 240732 | 79250825 |
Multimorbidity | 27.37 | 9.47 | 28 | 252803 | 1411 | 79490146 |
Drug resistance | 27.35 | 9.47 | 58 | 252773 | 42155 | 79449402 |
Blood glucose increased | 27.28 | 9.47 | 233 | 252598 | 114742 | 79376815 |
Salpingo-oophorectomy unilateral | 27.26 | 9.47 | 22 | 252809 | 812 | 79490745 |
Hypoaesthesia | 27.16 | 9.47 | 753 | 252078 | 178599 | 79312958 |
Oesophageal perforation | 27.07 | 9.47 | 29 | 252802 | 1542 | 79490015 |
Jaundice | 27.07 | 9.47 | 83 | 252748 | 53266 | 79438291 |
Cerebral infarction | 26.97 | 9.47 | 66 | 252765 | 45610 | 79445947 |
Growth retardation | 26.89 | 9.47 | 32 | 252799 | 1911 | 79489646 |
Urticaria thermal | 26.72 | 9.47 | 17 | 252814 | 428 | 79491129 |
Upper gastrointestinal haemorrhage | 26.69 | 9.47 | 57 | 252774 | 41323 | 79450234 |
Sleep disorder | 26.47 | 9.47 | 400 | 252431 | 85277 | 79406280 |
Pneumatosis intestinalis | 26.46 | 9.47 | 61 | 252770 | 6336 | 79485221 |
Chronic sinusitis | 26.28 | 9.47 | 96 | 252735 | 12930 | 79478627 |
Haematochezia | 25.85 | 9.47 | 406 | 252425 | 87239 | 79404318 |
Creatinine renal clearance decreased | 25.82 | 9.47 | 14 | 252817 | 18988 | 79472569 |
Lung neoplasm malignant | 25.80 | 9.47 | 30 | 252801 | 27762 | 79463795 |
Dermatitis atopic | 25.48 | 9.47 | 80 | 252751 | 9976 | 79481581 |
Toxic skin eruption | 25.44 | 9.47 | 20 | 252811 | 22273 | 79469284 |
Dyskinesia | 25.42 | 9.47 | 66 | 252765 | 44707 | 79446850 |
Enterobacter infection | 25.25 | 9.47 | 49 | 252782 | 4513 | 79487044 |
Pneumoretroperitoneum | 25.12 | 9.47 | 12 | 252819 | 168 | 79491389 |
Agranulocytosis | 25.09 | 9.47 | 67 | 252764 | 44963 | 79446594 |
Delusion | 25.02 | 9.47 | 17 | 252814 | 20406 | 79471151 |
Red blood cell sedimentation rate abnormal | 24.96 | 9.47 | 18 | 252813 | 20945 | 79470612 |
Body temperature decreased | 24.89 | 9.47 | 181 | 252650 | 31964 | 79459593 |
Therapy cessation | 24.85 | 9.47 | 51 | 252780 | 37511 | 79454046 |
Therapy interrupted | 24.85 | 9.47 | 38 | 252793 | 31303 | 79460254 |
Mobility decreased | 24.84 | 9.47 | 534 | 252297 | 121641 | 79369916 |
Thermophobia | 24.80 | 9.47 | 9 | 252822 | 59 | 79491498 |
Erythema nodosum | 24.57 | 9.47 | 53 | 252778 | 5264 | 79486293 |
Injection site reaction | 24.54 | 9.47 | 90 | 252741 | 54695 | 79436862 |
Natural killer-cell leukaemia | 24.36 | 9.47 | 10 | 252821 | 95 | 79491462 |
Pulmonary hypertension | 24.26 | 9.47 | 75 | 252756 | 48005 | 79443552 |
Metastases to bone | 24.18 | 9.47 | 25 | 252806 | 24402 | 79467155 |
Walking aid user | 24.14 | 9.47 | 79 | 252752 | 10069 | 79481488 |
Drug withdrawal syndrome | 23.95 | 9.47 | 46 | 252785 | 34672 | 79456885 |
Tremor | 23.91 | 9.47 | 387 | 252444 | 169696 | 79321861 |
Hypomagnesaemia | 23.79 | 9.47 | 73 | 252758 | 46838 | 79444719 |
Hyperhidrosis | 23.58 | 9.47 | 338 | 252493 | 151154 | 79340403 |
Epidural lipomatosis | 23.55 | 9.47 | 24 | 252807 | 1204 | 79490353 |
Asthenia | 23.49 | 9.47 | 1355 | 251476 | 510334 | 78981223 |
Candida infection | 23.46 | 9.47 | 204 | 252627 | 38010 | 79453547 |
Obesity | 23.42 | 9.47 | 191 | 252640 | 34934 | 79456623 |
Renal disorder | 23.20 | 9.47 | 63 | 252768 | 42042 | 79449515 |
Multiple sclerosis relapse | 23.18 | 9.47 | 73 | 252758 | 46460 | 79445097 |
Hypothalamic pituitary adrenal axis suppression | 23.17 | 9.47 | 14 | 252817 | 321 | 79491236 |
Skin ulcer | 22.93 | 9.47 | 91 | 252740 | 54059 | 79437498 |
Epiphysiolysis | 22.91 | 9.47 | 10 | 252821 | 112 | 79491445 |
Myelodysplastic syndrome | 22.83 | 9.47 | 38 | 252793 | 30263 | 79461294 |
Dysarthria | 22.52 | 9.47 | 124 | 252707 | 67498 | 79424059 |
Sinusitis | 22.51 | 9.47 | 794 | 252037 | 194707 | 79296850 |
Vaginal discharge | 22.36 | 9.47 | 63 | 252768 | 7400 | 79484157 |
Astrocytoma | 22.29 | 9.47 | 12 | 252819 | 219 | 79491338 |
Pneumonia aspiration | 22.19 | 9.47 | 123 | 252708 | 66844 | 79424713 |
Rheumatoid nodule | 22.06 | 9.47 | 14 | 252817 | 17424 | 79474133 |
Abdominal pain | 22.03 | 9.47 | 1475 | 251356 | 388094 | 79103463 |
Psychotic disorder | 22.03 | 9.47 | 63 | 252768 | 41339 | 79450218 |
Blood potassium increased | 21.79 | 9.47 | 37 | 252794 | 29238 | 79462319 |
Pulmonary oedema | 21.77 | 9.47 | 177 | 252654 | 88077 | 79403480 |
Proteinuria | 21.61 | 9.47 | 44 | 252787 | 32458 | 79459099 |
Normal tension glaucoma | 21.36 | 9.47 | 8 | 252823 | 58 | 79491499 |
Defaecation urgency | 21.35 | 9.47 | 53 | 252778 | 5771 | 79485786 |
Viraemia | 21.26 | 9.47 | 35 | 252796 | 2834 | 79488723 |
Oedema peripheral | 21.25 | 9.47 | 623 | 252208 | 251665 | 79239892 |
Femur fracture | 21.17 | 9.47 | 58 | 252773 | 38594 | 79452963 |
Adrenocorticotropic hormone deficiency | 21.16 | 9.47 | 24 | 252807 | 1361 | 79490196 |
Abscess bacterial | 21.11 | 9.47 | 19 | 252812 | 815 | 79490742 |
Mucous stools | 21.10 | 9.47 | 49 | 252782 | 5113 | 79486444 |
Musculoskeletal injury | 21.07 | 9.47 | 11 | 252820 | 188 | 79491369 |
Epistaxis | 21.00 | 9.47 | 239 | 252592 | 111276 | 79380281 |
Tendon disorder | 20.89 | 9.47 | 60 | 252771 | 7126 | 79484431 |
Blood corticotrophin decreased | 20.85 | 9.47 | 16 | 252815 | 548 | 79491009 |
Ventricular tachycardia | 20.74 | 9.47 | 66 | 252765 | 41869 | 79449688 |
Atrial flutter | 20.45 | 9.47 | 23 | 252808 | 21602 | 79469955 |
Thyrotoxic periodic paralysis | 20.26 | 9.47 | 10 | 252821 | 151 | 79491406 |
Herpes zoster | 20.18 | 9.47 | 193 | 252638 | 92890 | 79398667 |
Muscle rigidity | 20.08 | 9.47 | 20 | 252811 | 19862 | 79471695 |
Blood alkaline phosphatase increased | 19.98 | 9.47 | 119 | 252712 | 63545 | 79428012 |
Flushing | 19.98 | 9.47 | 392 | 252439 | 87876 | 79403681 |
Blood pressure diastolic decreased | 19.98 | 9.47 | 164 | 252667 | 30052 | 79461505 |
Dyspnoea exertional | 19.97 | 9.47 | 178 | 252653 | 86895 | 79404662 |
Enthesopathy | 19.92 | 9.47 | 6 | 252825 | 11602 | 79479955 |
Diarrhoea haemorrhagic | 19.89 | 9.47 | 89 | 252742 | 13145 | 79478412 |
Accidental overdose | 19.78 | 9.47 | 62 | 252769 | 39519 | 79452038 |
Gait inability | 19.75 | 9.47 | 279 | 252552 | 58638 | 79432919 |
Drug reaction with eosinophilia and systemic symptoms | 19.68 | 9.47 | 121 | 252710 | 64123 | 79427434 |
Enteritis | 19.65 | 9.47 | 95 | 252736 | 14488 | 79477069 |
Dizziness | 19.55 | 9.47 | 1421 | 251410 | 525020 | 78966537 |
Device difficult to use | 19.48 | 9.47 | 9 | 252822 | 13376 | 79478181 |
Blood urea increased | 19.41 | 9.47 | 84 | 252747 | 48706 | 79442851 |
Dyspnoea | 19.36 | 9.47 | 2401 | 250430 | 854624 | 78636933 |
Eosinophilia | 19.33 | 9.47 | 76 | 252755 | 45269 | 79446288 |
Pain | 19.32 | 9.47 | 2530 | 250301 | 701272 | 78790285 |
Allergy test positive | 19.25 | 9.47 | 17 | 252814 | 711 | 79490846 |
Herpes simplex oesophagitis | 19.22 | 9.47 | 13 | 252818 | 364 | 79491193 |
Myelopathy | 18.96 | 9.47 | 44 | 252787 | 4589 | 79486968 |
Feeling abnormal | 18.96 | 9.47 | 373 | 252458 | 158826 | 79332731 |
Bronchitis | 18.78 | 9.47 | 296 | 252535 | 130348 | 79361209 |
Ischaemic stroke | 18.68 | 9.47 | 49 | 252782 | 33082 | 79458475 |
Panniculitis | 18.51 | 9.47 | 8 | 252823 | 12363 | 79479194 |
Hallucination, auditory | 18.50 | 9.47 | 23 | 252808 | 20670 | 79470887 |
Drug eruption | 18.50 | 9.47 | 74 | 252757 | 43861 | 79447696 |
Haematoma | 18.33 | 9.47 | 94 | 252737 | 52101 | 79439456 |
Blood corticotrophin increased | 18.31 | 9.47 | 10 | 252821 | 188 | 79491369 |
White blood cell count increased | 18.26 | 9.47 | 150 | 252681 | 74483 | 79417074 |
Urinary retention | 18.23 | 9.47 | 105 | 252726 | 56525 | 79435032 |
Dry skin | 18.20 | 9.47 | 310 | 252521 | 67685 | 79423872 |
Atrioventricular block | 18.14 | 9.47 | 11 | 252820 | 14030 | 79477527 |
Bone marrow failure | 17.97 | 9.47 | 92 | 252739 | 51015 | 79440542 |
Sedation complication | 17.95 | 9.47 | 14 | 252817 | 15655 | 79475902 |
Diffuse large B-cell lymphoma | 17.95 | 9.47 | 8 | 252823 | 12141 | 79479416 |
Palmar-plantar erythrodysaesthesia syndrome | 17.94 | 9.47 | 50 | 252781 | 33084 | 79458473 |
Airway peak pressure increased | 17.81 | 9.47 | 12 | 252819 | 334 | 79491223 |
Symptom masked | 17.78 | 9.47 | 22 | 252809 | 1368 | 79490189 |
Colorectal cancer | 17.78 | 9.47 | 3 | 252828 | 8644 | 79482913 |
Dehydration | 17.75 | 9.47 | 626 | 252205 | 247561 | 79243996 |
Haematotoxicity | 17.61 | 9.47 | 14 | 252817 | 15505 | 79476052 |
Hyperemesis gravidarum | 17.47 | 9.47 | 13 | 252818 | 425 | 79491132 |
Angina unstable | 17.42 | 9.47 | 16 | 252815 | 16511 | 79475046 |
Gastrointestinal inflammation | 17.30 | 9.47 | 58 | 252773 | 7486 | 79484071 |
Pituitary infarction | 17.29 | 9.47 | 7 | 252824 | 64 | 79491493 |
Pharyngeal paraesthesia | 17.28 | 9.47 | 31 | 252800 | 2690 | 79488867 |
Cerebrospinal fluid leakage | 17.25 | 9.47 | 24 | 252807 | 1675 | 79489882 |
Right ventricular failure | 17.21 | 9.47 | 30 | 252801 | 23467 | 79468090 |
Granuloma skin | 17.15 | 9.47 | 4 | 252827 | 9170 | 79482387 |
Loss of employment | 17.11 | 9.47 | 30 | 252801 | 2557 | 79489000 |
Mitral valve incompetence | 17.08 | 9.47 | 41 | 252790 | 28524 | 79463033 |
Musculoskeletal disorder | 17.01 | 9.47 | 26 | 252805 | 21422 | 79470135 |
Cardiac failure chronic | 16.98 | 9.47 | 7 | 252824 | 11128 | 79480429 |
Adrenal disorder | 16.97 | 9.47 | 27 | 252804 | 2124 | 79489433 |
Cardiac failure acute | 16.97 | 9.47 | 21 | 252810 | 18908 | 79472649 |
Anticipatory anxiety | 16.94 | 9.47 | 20 | 252811 | 1184 | 79490373 |
Systemic infection | 16.81 | 9.47 | 5 | 252826 | 9747 | 79481810 |
Osteomyelitis | 16.77 | 9.47 | 51 | 252780 | 32814 | 79458743 |
Gastroenteritis norovirus | 16.76 | 9.47 | 33 | 252798 | 3073 | 79488484 |
Myalgia | 16.75 | 9.47 | 454 | 252377 | 185187 | 79306370 |
Catarrh | 16.72 | 9.47 | 27 | 252804 | 2151 | 79489406 |
Prostate cancer | 16.71 | 9.47 | 52 | 252779 | 33216 | 79458341 |
Acute generalised exanthematous pustulosis | 16.70 | 9.47 | 18 | 252813 | 17236 | 79474321 |
Pancytopenia | 16.65 | 9.47 | 399 | 252432 | 165346 | 79326211 |
Glioblastoma multiforme | 16.62 | 9.47 | 20 | 252811 | 1208 | 79490349 |
Osteoarthritis | 16.60 | 9.47 | 378 | 252453 | 86931 | 79404626 |
Hypernatraemia | 16.59 | 9.47 | 90 | 252741 | 14361 | 79477196 |
Underdose | 16.52 | 9.47 | 52 | 252779 | 33099 | 79458458 |
Pyoderma gangrenosum | 16.49 | 9.47 | 39 | 252792 | 4119 | 79487438 |
Intestinal intraepithelial lymphocytes increased | 16.39 | 9.47 | 9 | 252822 | 171 | 79491386 |
Thrombosis | 16.32 | 9.47 | 179 | 252652 | 83921 | 79407636 |
Sinusitis fungal | 16.31 | 9.47 | 28 | 252803 | 2346 | 79489211 |
Breast cancer female | 16.23 | 9.47 | 8 | 252823 | 11453 | 79480104 |
Blepharospasm | 16.19 | 9.47 | 48 | 252783 | 5803 | 79485754 |
Oedema | 16.16 | 9.47 | 495 | 252336 | 119085 | 79372472 |
Splenic peliosis | 16.00 | 9.47 | 5 | 252826 | 19 | 79491538 |
Altered state of consciousness | 15.92 | 9.47 | 78 | 252753 | 43744 | 79447813 |
Atrioventricular block first degree | 15.84 | 9.47 | 10 | 252821 | 12481 | 79479076 |
Miosis | 15.81 | 9.47 | 16 | 252815 | 15773 | 79475784 |
Rheumatoid arthritis | 15.79 | 9.47 | 522 | 252309 | 207948 | 79283609 |
Viral infection | 15.76 | 9.47 | 207 | 252624 | 42809 | 79448748 |
Kounis syndrome | 15.73 | 9.47 | 39 | 252792 | 4243 | 79487314 |
Weight decreased | 15.72 | 9.47 | 1319 | 251512 | 353879 | 79137678 |
Product quality issue | 15.70 | 9.47 | 55 | 252776 | 33885 | 79457672 |
Apathy | 15.64 | 9.47 | 11 | 252820 | 12966 | 79478591 |
Product use in unapproved indication | 15.60 | 9.47 | 956 | 251875 | 249403 | 79242154 |
Skin fragility | 15.57 | 9.47 | 17 | 252814 | 924 | 79490633 |
Glioma | 15.41 | 9.47 | 14 | 252817 | 608 | 79490949 |
Tooth injury | 15.38 | 9.47 | 25 | 252806 | 2003 | 79489554 |
Mydriasis | 15.37 | 9.47 | 20 | 252811 | 17623 | 79473934 |
Blood bilirubin increased | 15.36 | 9.47 | 135 | 252696 | 66097 | 79425460 |
Tenosynovitis | 15.31 | 9.47 | 16 | 252815 | 15538 | 79476019 |
Pregnancy | 15.28 | 9.47 | 141 | 252690 | 26710 | 79464847 |
Blood growth hormone increased | 15.24 | 9.47 | 15 | 252816 | 721 | 79490836 |
Renal cancer | 15.22 | 9.47 | 10 | 252821 | 12216 | 79479341 |
Therapeutic reaction time decreased | 15.16 | 9.47 | 34 | 252797 | 3467 | 79488090 |
Metastases to liver | 15.12 | 9.47 | 43 | 252788 | 28271 | 79463286 |
Unmasking of previously unidentified disease | 15.12 | 9.47 | 25 | 252806 | 2032 | 79489525 |
Blood calcium decreased | 15.10 | 9.47 | 51 | 252780 | 31768 | 79459789 |
Pleural effusion | 15.06 | 9.47 | 348 | 252483 | 144914 | 79346643 |
Oxygen saturation abnormal | 15.04 | 9.47 | 40 | 252791 | 4542 | 79487015 |
Mastocytosis | 15.03 | 9.47 | 13 | 252818 | 529 | 79491028 |
Akathisia | 15.00 | 9.47 | 12 | 252819 | 13247 | 79478310 |
Tendon rupture | 14.93 | 9.47 | 77 | 252754 | 12049 | 79479508 |
Abnormal behaviour | 14.92 | 9.47 | 62 | 252769 | 36359 | 79455198 |
Cerebral microangiopathy | 14.88 | 9.47 | 10 | 252821 | 277 | 79491280 |
Pouchitis | 14.87 | 9.47 | 17 | 252814 | 972 | 79490585 |
Granulocytopenia | 14.71 | 9.47 | 9 | 252822 | 11422 | 79480135 |
Electrocardiogram QRS complex prolonged | 14.69 | 9.47 | 8 | 252823 | 10825 | 79480732 |
Morganella infection | 14.68 | 9.47 | 18 | 252813 | 1109 | 79490448 |
Pulmonary embolism | 14.66 | 9.47 | 423 | 252408 | 171231 | 79320326 |
Migraine | 14.58 | 9.47 | 372 | 252459 | 87121 | 79404436 |
Acute graft versus host disease | 14.55 | 9.47 | 7 | 252824 | 10160 | 79481397 |
Natural killer cell count decreased | 14.52 | 9.47 | 6 | 252825 | 58 | 79491499 |
Anorectal disorder | 14.40 | 9.47 | 26 | 252805 | 2267 | 79489290 |
Aphasia | 14.33 | 9.47 | 88 | 252743 | 46644 | 79444913 |
Excessive eye blinking | 14.32 | 9.47 | 22 | 252809 | 1679 | 79489878 |
Lichen planus | 14.27 | 9.47 | 29 | 252802 | 2762 | 79488795 |
Burns second degree | 14.27 | 9.47 | 28 | 252803 | 2600 | 79488957 |
Gamma-glutamyltransferase increased | 14.26 | 9.47 | 108 | 252723 | 54572 | 79436985 |
Vertigo | 14.23 | 9.47 | 145 | 252686 | 68937 | 79422620 |
Dystonia | 14.20 | 9.47 | 29 | 252802 | 21370 | 79470187 |
Tongue disorder | 14.18 | 9.47 | 14 | 252817 | 13961 | 79477596 |
Oropharyngeal pain | 14.07 | 9.47 | 450 | 252381 | 108903 | 79382654 |
Anaplastic astrocytoma | 14.03 | 9.47 | 8 | 252823 | 164 | 79491393 |
Seizure | 14.03 | 9.47 | 474 | 252357 | 188360 | 79303197 |
Hepatic cancer | 13.96 | 9.47 | 8 | 252823 | 10521 | 79481036 |
Exposure to SARS-CoV-2 | 13.90 | 9.47 | 24 | 252807 | 2020 | 79489537 |
Dermatitis diaper | 13.90 | 9.47 | 10 | 252821 | 310 | 79491247 |
Ventricular hypokinesia | 13.88 | 9.47 | 6 | 252825 | 9273 | 79482284 |
C-reactive protein abnormal | 13.86 | 9.47 | 223 | 252608 | 48144 | 79443413 |
Strabismus | 13.86 | 9.47 | 27 | 252804 | 2494 | 79489063 |
Abdominal pain upper | 13.82 | 9.47 | 854 | 251977 | 222965 | 79268592 |
Cerebral vasoconstriction | 13.79 | 9.47 | 20 | 252811 | 1450 | 79490107 |
Faecaloma | 13.67 | 9.47 | 10 | 252821 | 11554 | 79480003 |
Weight fluctuation | 13.59 | 9.47 | 73 | 252758 | 11602 | 79479955 |
Hypercholesterolaemia | 13.51 | 9.47 | 122 | 252709 | 22973 | 79468584 |
Proctitis | 13.48 | 9.47 | 48 | 252783 | 6384 | 79485173 |
Red blood cell count decreased | 13.44 | 9.47 | 117 | 252714 | 57396 | 79434161 |
SARS-CoV-2 test negative | 13.37 | 9.47 | 19 | 252812 | 1352 | 79490205 |
Autoimmune nephritis | 13.37 | 9.47 | 14 | 252817 | 725 | 79490832 |
Purpura | 13.36 | 9.47 | 26 | 252805 | 19501 | 79472056 |
Myoclonus | 13.35 | 9.47 | 44 | 252787 | 27616 | 79463941 |
Tubulointerstitial nephritis | 13.35 | 9.47 | 69 | 252762 | 38166 | 79453391 |
Peptic ulcer haemorrhage | 13.32 | 9.47 | 16 | 252815 | 965 | 79490592 |
Atrioventricular block complete | 13.30 | 9.47 | 20 | 252811 | 16590 | 79474967 |
Germ cell cancer | 13.29 | 9.47 | 8 | 252823 | 182 | 79491375 |
Coronavirus infection | 13.27 | 9.47 | 53 | 252778 | 7444 | 79484113 |
Haematemesis | 13.27 | 9.47 | 104 | 252727 | 52160 | 79439397 |
Hyperreflexia | 13.23 | 9.47 | 5 | 252826 | 8380 | 79483177 |
Hypertension | 13.23 | 9.47 | 1220 | 251611 | 329772 | 79161785 |
Transplant rejection | 13.19 | 9.47 | 26 | 252805 | 19411 | 79472146 |
Cortisol abnormal | 13.16 | 9.47 | 6 | 252825 | 75 | 79491482 |
Excessive skin | 13.14 | 9.47 | 7 | 252824 | 125 | 79491432 |
Gingival pain | 13.14 | 9.47 | 60 | 252771 | 8938 | 79482619 |
Nasal polyps | 13.13 | 9.47 | 52 | 252779 | 7275 | 79484282 |
Cholestasis | 13.08 | 9.47 | 104 | 252727 | 52005 | 79439552 |
Pseudohypoaldosteronism | 13.04 | 9.47 | 5 | 252826 | 39 | 79491518 |
Blood potassium decreased | 13.03 | 9.47 | 90 | 252741 | 46422 | 79445135 |
Shunt malfunction | 13 | 9.47 | 9 | 252822 | 262 | 79491295 |
Therapy partial responder | 12.94 | 9.47 | 22 | 252809 | 17375 | 79474182 |
Ulcer | 12.92 | 9.47 | 50 | 252781 | 29922 | 79461635 |
Duodenal ulcer | 12.83 | 9.47 | 20 | 252811 | 16349 | 79475208 |
Dysphagia | 12.83 | 9.47 | 292 | 252539 | 121844 | 79369713 |
Ventricular arrhythmia | 12.78 | 9.47 | 6 | 252825 | 8834 | 79482723 |
Haemorrhoids | 12.77 | 9.47 | 145 | 252686 | 28983 | 79462574 |
Bone disorder | 12.60 | 9.47 | 26 | 252805 | 19087 | 79472470 |
Product storage error | 12.55 | 9.47 | 20 | 252811 | 16206 | 79475351 |
Restlessness | 12.52 | 9.47 | 91 | 252740 | 46401 | 79445156 |
Drug ineffective | 12.52 | 9.47 | 3722 | 249109 | 1077191 | 78414366 |
Haemorrhagic stroke | 12.49 | 9.47 | 10 | 252821 | 11036 | 79480521 |
Glomerular filtration rate decreased | 12.48 | 9.47 | 34 | 252797 | 22668 | 79468889 |
Tuberculosis gastrointestinal | 12.45 | 9.47 | 12 | 252819 | 562 | 79490995 |
Vaginal infection | 12.43 | 9.47 | 44 | 252787 | 5836 | 79485721 |
Superinfection | 12.42 | 9.47 | 39 | 252792 | 4863 | 79486694 |
Aborted pregnancy | 12.42 | 9.47 | 5 | 252826 | 45 | 79491512 |
Inflammation | 12.38 | 9.47 | 387 | 252444 | 93366 | 79398191 |
Antithrombin III | 12.37 | 9.47 | 6 | 252825 | 87 | 79491470 |
Breast cancer stage I | 12.37 | 9.47 | 3 | 252828 | 6697 | 79484860 |
Product label confusion | 12.27 | 9.47 | 20 | 252811 | 1606 | 79489951 |
Hypertensive crisis | 12.27 | 9.47 | 30 | 252801 | 20740 | 79470817 |
B-lymphocyte count increased | 12.26 | 9.47 | 7 | 252824 | 144 | 79491413 |
Thyroxine free decreased | 12.25 | 9.47 | 16 | 252815 | 1051 | 79490506 |
Cryptitis | 12.23 | 9.47 | 9 | 252822 | 289 | 79491268 |
Hypoaldosteronism | 12.23 | 9.47 | 10 | 252821 | 376 | 79491181 |
Meningitis tuberculous | 12.20 | 9.47 | 17 | 252814 | 1188 | 79490369 |
Plasma cell myeloma | 12.16 | 9.47 | 109 | 252722 | 53150 | 79438407 |
Eye haemorrhage | 12.12 | 9.47 | 8 | 252823 | 9749 | 79481808 |
Eosinophilic oesophagitis | 12.11 | 9.47 | 12 | 252819 | 582 | 79490975 |
Optic nerve operation | 12.09 | 9.47 | 11 | 252820 | 479 | 79491078 |
Angioedema | 12.05 | 9.47 | 169 | 252662 | 75866 | 79415691 |
Renal injury | 12.05 | 9.47 | 22 | 252809 | 16905 | 79474652 |
Microvillous inclusion disease | 12.05 | 9.47 | 8 | 252823 | 217 | 79491340 |
Lymphocyte count decreased | 12.05 | 9.47 | 94 | 252737 | 47195 | 79444362 |
Diplegia | 12.04 | 9.47 | 21 | 252810 | 1782 | 79489775 |
Pituitary tumour | 12.02 | 9.47 | 17 | 252814 | 1205 | 79490352 |
Tessellated fundus | 11.95 | 9.47 | 5 | 252826 | 50 | 79491507 |
Hepatocellular injury | 11.94 | 9.47 | 95 | 252736 | 47498 | 79444059 |
Embolism venous | 11.94 | 9.47 | 35 | 252796 | 4204 | 79487353 |
Gastric ulcer | 11.94 | 9.47 | 61 | 252770 | 33844 | 79457713 |
Probiotic therapy | 11.88 | 9.47 | 7 | 252824 | 153 | 79491404 |
Abscess | 11.82 | 9.47 | 118 | 252713 | 22833 | 79468724 |
Rib fracture | 11.81 | 9.47 | 47 | 252784 | 27900 | 79463657 |
Jaundice cholestatic | 11.80 | 9.47 | 11 | 252820 | 11273 | 79480284 |
Dry mouth | 11.80 | 9.47 | 364 | 252467 | 87655 | 79403902 |
Scrotal infection | 11.79 | 9.47 | 12 | 252819 | 601 | 79490956 |
Optic glioma | 11.78 | 9.47 | 5 | 252826 | 52 | 79491505 |
Disseminated cryptococcosis | 11.78 | 9.47 | 21 | 252810 | 1813 | 79489744 |
Gastric cancer | 11.78 | 9.47 | 9 | 252822 | 10170 | 79481387 |
Metastases to lung | 11.73 | 9.47 | 25 | 252806 | 18138 | 79473419 |
Enterocolonic fistula | 11.72 | 9.47 | 7 | 252824 | 157 | 79491400 |
Nephropathy toxic | 11.67 | 9.47 | 30 | 252801 | 20389 | 79471168 |
Vaginal abscess | 11.66 | 9.47 | 10 | 252821 | 402 | 79491155 |
Uterine cyst | 11.66 | 9.47 | 9 | 252822 | 311 | 79491246 |
Bronchopulmonary aspergillosis | 11.66 | 9.47 | 115 | 252716 | 22179 | 79469378 |
Injection site bruising | 11.66 | 9.47 | 79 | 252752 | 40923 | 79450634 |
Constipation | 11.65 | 9.47 | 757 | 252074 | 282293 | 79209264 |
Anorectal ulcer | 11.62 | 9.47 | 5 | 252826 | 54 | 79491503 |
Non-consummation | 11.62 | 9.47 | 5 | 252826 | 54 | 79491503 |
Vulvovaginal candidiasis | 11.55 | 9.47 | 25 | 252806 | 2489 | 79489068 |
Cushing's syndrome | 11.54 | 9.47 | 15 | 252816 | 980 | 79490577 |
Intestinal resection | 11.54 | 9.47 | 32 | 252799 | 3725 | 79487832 |
Synovial cyst | 11.52 | 9.47 | 9 | 252822 | 10056 | 79481501 |
Sinus node dysfunction | 11.49 | 9.47 | 5 | 252826 | 7696 | 79483861 |
Product monitoring error | 11.48 | 9.47 | 7 | 252824 | 8899 | 79482658 |
Idiopathic intracranial hypertension | 11.48 | 9.47 | 29 | 252802 | 3193 | 79488364 |
Dysgeusia | 11.37 | 9.47 | 121 | 252710 | 57056 | 79434501 |
Viral parotitis | 11.34 | 9.47 | 3 | 252828 | 5 | 79491552 |
Mental status changes | 11.27 | 9.47 | 147 | 252684 | 66812 | 79424745 |
Growth hormone deficiency | 11.27 | 9.47 | 10 | 252821 | 421 | 79491136 |
Disorientation | 11.25 | 9.47 | 136 | 252695 | 62640 | 79428917 |
Hepatitis acute | 11.24 | 9.47 | 20 | 252811 | 15522 | 79476035 |
Pancreatic carcinoma | 11.21 | 9.47 | 16 | 252815 | 13561 | 79477996 |
Hypertriglyceridaemia | 11.20 | 9.47 | 74 | 252757 | 12666 | 79478891 |
Chorioretinopathy | 11.19 | 9.47 | 23 | 252808 | 2208 | 79489349 |
Cryptococcal fungaemia | 11.15 | 9.47 | 7 | 252824 | 172 | 79491385 |
Basal cell carcinoma | 11.14 | 9.47 | 71 | 252760 | 37304 | 79454253 |
Respiratory rate increased | 11.09 | 9.47 | 111 | 252720 | 21489 | 79470068 |
Glucocorticoid deficiency | 11.08 | 9.47 | 12 | 252819 | 646 | 79490911 |
Sputum increased | 11.05 | 9.47 | 36 | 252795 | 4577 | 79486980 |
Coordination abnormal | 11.04 | 9.47 | 24 | 252807 | 17288 | 79474269 |
Hypocalcaemia | 11.04 | 9.47 | 103 | 252728 | 49821 | 79441736 |
Cryptococcal meningoencephalitis | 11.01 | 9.47 | 8 | 252823 | 252 | 79491305 |
Psychomotor retardation | 10.98 | 9.47 | 3 | 252828 | 6181 | 79485376 |
Drug tolerance | 10.93 | 9.47 | 7 | 252824 | 8668 | 79482889 |
Posturing | 10.88 | 9.47 | 15 | 252816 | 1038 | 79490519 |
Electrocardiogram abnormal | 10.84 | 9.47 | 23 | 252808 | 16714 | 79474843 |
Death neonatal | 10.83 | 9.47 | 12 | 252819 | 663 | 79490894 |
Full blood count decreased | 10.77 | 9.47 | 46 | 252785 | 26773 | 79464784 |
Adenoidal hypertrophy | 10.71 | 9.47 | 7 | 252824 | 185 | 79491372 |
Seronegative arthritis | 10.69 | 9.47 | 36 | 252795 | 4656 | 79486901 |
Perineal infection | 10.69 | 9.47 | 13 | 252818 | 794 | 79490763 |
COVID-19 pneumonia | 10.68 | 9.47 | 51 | 252780 | 28798 | 79462759 |
Hyperuricaemia | 10.67 | 9.47 | 13 | 252818 | 11786 | 79479771 |
Eosinophil count increased | 10.67 | 9.47 | 24 | 252807 | 17081 | 79474476 |
Joint effusion | 10.66 | 9.47 | 26 | 252805 | 17988 | 79473569 |
Therapeutic product effect incomplete | 10.65 | 9.47 | 355 | 252476 | 141290 | 79350267 |
Lymphocytic hypophysitis | 10.64 | 9.47 | 11 | 252820 | 561 | 79490996 |
Rectal abscess | 10.63 | 9.47 | 22 | 252809 | 2123 | 79489434 |
Coronary arterial stent insertion | 10.60 | 9.47 | 3 | 252828 | 6041 | 79485516 |
Mucosal hyperaemia | 10.60 | 9.47 | 5 | 252826 | 68 | 79491489 |
Intestinal stenosis | 10.58 | 9.47 | 31 | 252800 | 3723 | 79487834 |
Torsade de pointes | 10.56 | 9.47 | 29 | 252802 | 19283 | 79472274 |
Hypoxia | 10.51 | 9.47 | 248 | 252583 | 102995 | 79388562 |
Protein urine present | 10.41 | 9.47 | 10 | 252821 | 10102 | 79481455 |
Hepatocellular carcinoma | 10.41 | 9.47 | 8 | 252823 | 9013 | 79482544 |
Uveitis | 10.41 | 9.47 | 90 | 252741 | 16740 | 79474817 |
Hallucination, visual | 10.36 | 9.47 | 61 | 252770 | 32668 | 79458889 |
Anorectal discomfort | 10.35 | 9.47 | 30 | 252801 | 3581 | 79487976 |
Faecal calprotectin abnormal | 10.32 | 9.47 | 7 | 252824 | 197 | 79491360 |
Renal salt-wasting syndrome | 10.25 | 9.47 | 12 | 252819 | 704 | 79490853 |
Paradoxical drug reaction | 10.20 | 9.47 | 5 | 252826 | 7180 | 79484377 |
Nodule | 10.15 | 9.47 | 38 | 252793 | 22956 | 79468601 |
Clostridium difficile infection | 10.15 | 9.47 | 191 | 252640 | 42494 | 79449063 |
Sexual dysfunction | 10.14 | 9.47 | 6 | 252825 | 7757 | 79483800 |
Infant irritability | 10.14 | 9.47 | 3 | 252828 | 9 | 79491548 |
Basilar artery aneurysm | 10.13 | 9.47 | 4 | 252827 | 34 | 79491523 |
Normochromic normocytic anaemia | 10.06 | 9.47 | 6 | 252825 | 7721 | 79483836 |
Vaginal flatulence | 10.04 | 9.47 | 24 | 252807 | 2551 | 79489006 |
Gonadotrophin deficiency | 10.03 | 9.47 | 4 | 252827 | 35 | 79491522 |
Rash erythematous | 10.03 | 9.47 | 247 | 252584 | 57522 | 79434035 |
Thyrotoxic crisis | 9.97 | 9.47 | 16 | 252815 | 1268 | 79490289 |
Pulmonary alveolar haemorrhage | 9.97 | 9.47 | 13 | 252818 | 11444 | 79480113 |
Sitting disability | 9.96 | 9.47 | 9 | 252822 | 388 | 79491169 |
Oesophageal adenocarcinoma recurrent | 9.93 | 9.47 | 4 | 252827 | 36 | 79491521 |
Manipulation | 9.93 | 9.47 | 5 | 252826 | 79 | 79491478 |
Multiple-drug resistance | 9.93 | 9.47 | 8 | 252823 | 8800 | 79482757 |
Nail disorder | 9.91 | 9.47 | 68 | 252763 | 11784 | 79479773 |
Hepatitis C | 9.90 | 9.47 | 14 | 252817 | 11911 | 79479646 |
Hyperamylasaemia | 9.89 | 9.47 | 15 | 252816 | 1132 | 79490425 |
Cataract | 9.87 | 9.47 | 138 | 252693 | 61982 | 79429575 |
Thyroglossal cyst infection | 9.84 | 9.47 | 4 | 252827 | 37 | 79491520 |
Visual pathway disorder | 9.82 | 9.47 | 5 | 252826 | 81 | 79491476 |
Gram stain positive | 9.80 | 9.47 | 6 | 252825 | 141 | 79491416 |
Deafness | 9.79 | 9.47 | 34 | 252797 | 21003 | 79470554 |
Aphthous ulcer | 9.77 | 9.47 | 89 | 252742 | 16800 | 79474757 |
Catheterisation cardiac | 9.76 | 9.47 | 3 | 252828 | 5725 | 79485832 |
Urosepsis | 9.71 | 9.47 | 47 | 252784 | 26448 | 79465109 |
Myelitis transverse | 9.68 | 9.47 | 20 | 252811 | 1927 | 79489630 |
Hypoperfusion | 9.66 | 9.47 | 24 | 252807 | 2615 | 79488942 |
Herpes simplex | 9.65 | 9.47 | 69 | 252762 | 12118 | 79479439 |
Shock haemorrhagic | 9.62 | 9.47 | 32 | 252799 | 20028 | 79471529 |
Neutrophilic panniculitis | 9.60 | 9.47 | 5 | 252826 | 85 | 79491472 |
Status asthmaticus | 9.60 | 9.47 | 14 | 252817 | 1020 | 79490537 |
Acute hepatic failure | 9.60 | 9.47 | 56 | 252775 | 30057 | 79461500 |
Infusion site streaking | 9.55 | 9.47 | 10 | 252821 | 518 | 79491039 |
Ischaemia | 9.53 | 9.47 | 7 | 252824 | 8068 | 79483489 |
Gestational diabetes | 9.52 | 9.47 | 4 | 252827 | 6289 | 79485268 |
End stage renal disease | 9.51 | 9.47 | 15 | 252816 | 12205 | 79479352 |
Arteriosclerosis | 9.50 | 9.47 | 28 | 252803 | 18199 | 79473358 |
Pituitary-dependent Cushing's syndrome | 9.48 | 9.47 | 3 | 252828 | 12 | 79491545 |
Skin injury | 9.48 | 9.47 | 28 | 252803 | 3378 | 79488179 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug-induced liver injury | 56.37 | 37.89 | 16 | 205 | 58 | 89513 |
Aspergillus infection | 56.06 | 37.89 | 17 | 204 | 82 | 89489 |
Product use issue | 41.47 | 37.89 | 16 | 205 | 175 | 89396 |
Hepatotoxicity | 41.10 | 37.89 | 14 | 207 | 103 | 89468 |
Source | Code | Description |
---|---|---|
ATC | A01AC03 | ALIMENTARY TRACT AND METABOLISM STOMATOLOGICAL PREPARATIONS STOMATOLOGICAL PREPARATIONS Corticosteroids for local oral treatment |
ATC | A07EA02 | ALIMENTARY TRACT AND METABOLISM ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS INTESTINAL ANTIINFLAMMATORY AGENTS Corticosteroids acting locally |
ATC | C05AA01 | CARDIOVASCULAR SYSTEM VASOPROTECTIVES AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Corticosteroids |
ATC | D07AA02 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, weak (group I) |
ATC | D07BA04 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS Corticosteroids, weak, combinations with antiseptics |
ATC | D07CA01 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS Corticosteroids, weak, combinations with antibiotics |
ATC | D07XA01 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, OTHER COMBINATIONS Corticosteroids, weak, other combinations |
ATC | H02AB09 | SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS CORTICOSTEROIDS FOR SYSTEMIC USE CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN Glucocorticoids |
ATC | R01AD60 | RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Corticosteroids |
ATC | S01BA02 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS Corticosteroids, plain |
ATC | S01BB01 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS Corticosteroids and mydriatics in combination |
ATC | S01CA03 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION Corticosteroids and antiinfectives in combination |
ATC | S01CB03 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION Corticosteroids/antiinfectives/mydriatics in combination |
ATC | S02BA01 | SENSORY ORGANS OTOLOGICALS CORTICOSTEROIDS Corticosteroids |
ATC | S02CA03 | SENSORY ORGANS OTOLOGICALS CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION Corticosteroids and antiinfectives in combination |
ATC | S03CA04 | SENSORY ORGANS OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION Corticosteroids and antiinfectives in combination |
FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
FDA EPC | N0000175576 | Corticosteroid |
MeSH PA | D000893 | Anti-Inflammatory Agents |
CHEBI has role | CHEBI:35472 | anti-inflammatory drugs |
CHEBI has role | CHEBI:49167 | anti-asthmatic drugs |
CHEBI has role | CHEBI:50857 | anti-allergic drugs |
CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
CHEBI has role | CHEBI:88188 | allergenic drug |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Disorder of musculoskeletal system | indication | 928000 | DOID:17 |
Cerebral edema | indication | 2032001 | |
Otitis externa | indication | 3135009 | |
Proctitis | indication | 3951002 | DOID:3127 |
Keratitis | indication | 5888003 | DOID:4677 |
Tinea pedis | indication | 6020002 | DOID:12403 |
Berylliosis | indication | 8247009 | DOID:10322 |
Psoriasis | indication | 9014002 | DOID:8893 |
Ankylosing spondylitis | indication | 9631008 | DOID:7147 |
Cyclitis | indication | 17657000 | |
Rheumatic heart disease | indication | 23685000 | |
Atopic dermatitis | indication | 24079001 | DOID:3310 |
Inflammatory bowel disease | indication | 24526004 | DOID:0050589 |
Multiple sclerosis | indication | 24700007 | DOID:2377 |
Severe adrenal insufficiency | indication | 24867002 | |
Sarcoidosis | indication | 31541009 | DOID:11335 |
Idiopathic thrombocytopenic purpura | indication | 32273002 | DOID:8924 |
Psoriasis with arthropathy | indication | 33339001 | |
Crohn's disease | indication | 34000006 | |
Tendinitis | indication | 34840004 | DOID:971 |
Erythema multiforme | indication | 36715001 | |
Contact dermatitis | indication | 40275004 | DOID:2773 |
Angioedema | indication | 41291007 | DOID:1558 |
Humoral hypercalcemia of malignancy | indication | 47709007 | |
Articular gout | indication | 48440001 | DOID:13189 |
Seborrheic dermatitis | indication | 50563003 | DOID:8741 |
Edema of larynx | indication | 51599000 | |
Chronic ulcerative proctitis | indication | 52231000 | |
Nephrotic syndrome | indication | 52254009 | DOID:1184 |
Lichen simplex chronicus | indication | 53891004 | |
Systemic lupus erythematosus | indication | 55464009 | DOID:9074 |
Allergic rhinitis | indication | 61582004 | |
Ulcerative colitis | indication | 64766004 | DOID:8577 |
Lรถffler's syndrome | indication | 64936001 | DOID:9503 |
Iritis | indication | 65074000 | DOID:1406 |
Pemphigus | indication | 65172003 | DOID:9182 |
Granuloma annulare | indication | 65508009 | DOID:3777 |
Tenosynovitis | indication | 67801009 | DOID:970 |
Blepharoconjunctivitis | indication | 68659002 | DOID:2456 |
Rheumatoid arthritis | indication | 69896004 | DOID:7148 |
Hemorrhoids | indication | 70153002 | DOID:9746 |
Transfusion reaction due to serum protein reaction | indication | 72284000 | |
Acquired thrombocytopenia | indication | 74576004 | DOID:11126 |
Iridocyclitis | indication | 77971008 | |
Thyroiditis | indication | 82119001 | DOID:7166 |
Bursitis | indication | 84017003 | DOID:2965 |
Tinea corporis | indication | 84849002 | |
Autoimmune disease | indication | 85828009 | |
Corneal abrasion | indication | 85848002 | |
Infective otitis externa | indication | 86981007 | DOID:9463 |
Infection by larvae of Trichinella spiralis | indication | 88264003 | |
Acne vulgaris | indication | 88616000 | |
Congenital hypoplastic anemia | indication | 88854002 | DOID:1339 |
Pruritus ani | indication | 90446007 | |
Corneal ulcer | indication | 91514001 | DOID:8463 |
Acute lymphoid leukemia | indication | 91857003 | DOID:9952 |
Dermatitis herpetiformis | indication | 111196000 | DOID:8505 |
Hodgkin's disease | indication | 118599009 | |
Non-Hodgkin's lymphoma | indication | 118601006 | |
Mycosis fungoides | indication | 118618005 | |
Uveitis | indication | 128473001 | DOID:13141 |
Aspiration pneumonitis | indication | 155597006 | |
Asthma | indication | 195967001 | DOID:2841 |
Discoid lupus erythematosus | indication | 200938002 | |
Plaque psoriasis | indication | 200965009 | |
Transplanted organ rejection | indication | 213148006 | |
Malignant otitis externa due to Pseudomonas aeruginosa | indication | 232230009 | |
Congenital adrenal hyperplasia | indication | 237751000 | |
Scalp psoriasis | indication | 238608008 | |
Punctate keratopathy | indication | 246936005 | |
Adrenogenital disorder | indication | 267395000 | DOID:0050811 |
Pruritus of genital organs | indication | 267802000 | |
Eruption of skin | indication | 271807003 | DOID:0050486 |
Infective blepharitis | indication | 312219000 | |
Bacterial keratitis | indication | 314557000 | |
Disorder of eye | indication | 371405004 | DOID:5614 |
Primary adrenocortical insufficiency | indication | 373662000 | |
Adrenal cortical hypofunction | indication | 386584007 | DOID:10493 |
Herpes zoster keratitis | indication | 397573005 | |
Rosacea | indication | 398909004 | DOID:8881 |
Tinea cruris | indication | 399029005 | |
Erythroderma | indication | 399992009 | |
Primary cutaneous T-cell lymphoma | indication | 400122007 | |
Recurrent herpes simplex labialis | indication | 402892009 | |
Autoimmune hemolytic anemia | indication | 413603009 | DOID:718 |
Synovitis | indication | 416209007 | DOID:2703 |
Aphthous ulcer of mouth | indication | 426965005 | DOID:9663 |
Allergic conjunctivitis | indication | 473460002 | DOID:11204 |
Post traumatic osteoarthritis | indication | 699262001 | |
Itching of ear | indication | 699392007 | |
Inflammatory dermatosis | indication | 703938007 | |
Post-Op Ocular Inflammation | indication | ||
Mastoidectomy Cavity Infections | indication | ||
Superficial Ocular Infection | indication | ||
Gingival Disorders | indication | ||
Minor Bacterial Skin Infections | indication | ||
Synovitis due to Osteoarthritis | indication | ||
Diagnostic Test for Cushing's Syndrome | indication | ||
Transfusion Reaction Urticaria | indication | ||
Staphylococcus Aureus Otitis Externa | indication | ||
Systemic Dermatomyositis | indication | ||
Erythroblastic Anemia | indication | ||
Chronic purulent otitis media | off-label use | 38394007 | DOID:14247 |
Respiratory distress syndrome in the newborn | off-label use | 46775006 | |
Adrenoleukodystrophy | off-label use | 65389002 | DOID:10588 |
Pityriasis simplex | off-label use | 200767005 | |
Allergic otitis externa | off-label use | 405821001 | |
Itching of skin | off-label use | 418363000 | |
Otitis Externa Seborrhea | off-label use | ||
Neonatal Bronchopulmonary Dysplasia | off-label use | ||
Congenital Pituitary Hypoplasia | off-label use | ||
Otitis Externa Eczema | off-label use | ||
Mycosis | contraindication | 3218000 | DOID:1564 |
Ocular hypertension | contraindication | 4210003 | DOID:9282 |
Herpes simplex keratitis | contraindication | 9389005 | |
Bacterial septicemia | contraindication | 10001005 | DOID:0040085 |
Inactive tuberculosis | contraindication | 11999007 | |
Peptic ulcer | contraindication | 13200003 | DOID:750 |
Measles | contraindication | 14189004 | DOID:8622 |
Esophagitis | contraindication | 16761005 | DOID:11963 |
Mood swings | contraindication | 18963009 | |
Infection of skin AND/OR subcutaneous tissue | contraindication | 19824006 | |
Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
Herpes zoster auricularis | contraindication | 21954000 | DOID:9210 |
Glaucoma | contraindication | 23986001 | DOID:1686 |
Abscess of intestine | contraindication | 24557004 | |
Acute tuberculosis | contraindication | 25629007 | |
Shock | contraindication | 27942005 | |
Herpes simplex dendritic keratitis | contraindication | 29943008 | |
Fungal infection of eye | contraindication | 31194008 | |
Bullous myringitis | contraindication | 33528003 | DOID:13791 |
Severe myopia | contraindication | 34187009 | |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Gastrointestinal fistula | contraindication | 37831005 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Infectious disease | contraindication | 40733004 | |
Hypothyroidism | contraindication | 40930008 | DOID:1459 |
Hypokalemia | contraindication | 43339004 | |
Chronic heart failure | contraindication | 48447003 | |
Tuberculosis of eye | contraindication | 49107007 | |
Duodenal ulcer disease | contraindication | 51868009 | DOID:1724 |
Perforation of tympanic membrane | contraindication | 60442001 | |
Osteoporosis | contraindication | 64859006 | DOID:11476 |
Psychotic disorder | contraindication | 69322001 | |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Hypopituitarism | contraindication | 74728003 | DOID:9406 |
Third degree burn injury | contraindication | 80247002 | |
Hyperglycemia | contraindication | 80394007 | DOID:4195 |
Decreased respiratory function | contraindication | 80954004 | |
Open-angle glaucoma | contraindication | 84494001 | DOID:1067 |
Krukenberg spindle | contraindication | 85430004 | |
Herpes simplex | contraindication | 88594005 | DOID:8566 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Disorder of mucous membrane | contraindication | 95351003 | |
Bilateral cataracts | contraindication | 95722004 | |
Open wound | contraindication | 125643001 | |
Eye infection | contraindication | 128351009 | |
Seizure disorder | contraindication | 128613002 | |
Bacterial infection of eye | contraindication | 128984004 | |
Disorder of muscle | contraindication | 129565002 | DOID:423 |
Tuberculosis of ear | contraindication | 186269001 | |
Ophthalmic herpes simplex | contraindication | 186542001 | |
Heart block | contraindication | 233916004 | |
Anastomosis of intestine | contraindication | 235407009 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Condyloma acuminatum | contraindication | 240542006 | DOID:11168 |
Telangiectasia disorder | contraindication | 247479008 | |
Diverticulitis of gastrointestinal tract | contraindication | 271366000 | |
Injury of eye region | contraindication | 282752000 | |
Varicella-zoster virus infection | contraindication | 309465005 | |
Viral eye infection | contraindication | 312132001 | |
Viral ear infection | contraindication | 312137007 | |
Fungal ear infection | contraindication | 312148000 | |
Infective otitis media | contraindication | 312218008 | |
Skin irritation | contraindication | 367466007 | |
Vaccinia keratitis | contraindication | 397552005 | |
Gastric ulcer | contraindication | 397825006 | DOID:10808 |
Atrophoderma | contraindication | 399979006 | |
Peripheral vascular disease | contraindication | 400047006 | |
Blister | contraindication | 417237009 | |
Denuded skin | contraindication | 418242004 | |
Exposure to varicella | contraindication | 444453009 |
Species | Use | Relation |
---|---|---|
Cats | Acute otitis externa | Indication |
Cats | Chronic otitis externa | Indication |
Cats | Ear canker | Indication |
Cats | Inflammatory conditions of the external ear canal | Indication |
Cats | Allergy | Indication |
Cats | Infectious skin conditions | Indication |
Cats | Traumatic skin conditions | Indication |
Cats | Prevention of bacterial infections in superficial wounds | Indication |
Cats | Prevention of bacterial infections in cuts | Indication |
Cats | Prevention of bacterial infections in abrasions | Indication |
Cats | Allergic dermatoses | Indication |
Cats | Infections associated with minor burns and wounds | Indication |
Cats | Nonspecific pruritus | Indication |
Dogs | Acute otitis externa | Indication |
Dogs | Chronic otitis externa | Indication |
Dogs | Ear canker | Indication |
Dogs | Inflammatory conditions of the external ear canal | Indication |
Dogs | Allergy | Indication |
Dogs | Infectious skin conditions | Indication |
Dogs | Traumatic skin conditions | Indication |
Dogs | Prevention of bacterial infections in superficial wounds | Indication |
Dogs | Prevention of bacterial infections in cuts | Indication |
Dogs | Prevention of bacterial infections in abrasions | Indication |
Dogs | Allergic dermatoses | Indication |
Dogs | Infections associated with minor burns and wounds | Indication |
Dogs | Nonspecific pruritus | Indication |
Horses | No Use Class Stated Or Implied | Indication |
Product | Applicant | Ingredients |
---|---|---|
Liqua-Cortril Spray, Terra-Cortril Spray | Zoetis Inc. | 2 |
Cortisporin Veterinary Ophthalmic Ointment | Intervet Inc. | 4 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 12.31 | acidic |
pKa2 | 13.65 | acidic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
0.5MG | ALKINDI SPRINKLE | ETON | N213876 | Sept. 29, 2020 | RX | GRANULE | ORAL | 9717740 | Nov. 19, 2032 | TREATMENT OF ADRENAL INSUFFICIENCY |
1MG | ALKINDI SPRINKLE | ETON | N213876 | Sept. 29, 2020 | RX | GRANULE | ORAL | 9717740 | Nov. 19, 2032 | TREATMENT OF ADRENAL INSUFFICIENCY |
2MG | ALKINDI SPRINKLE | ETON | N213876 | Sept. 29, 2020 | RX | GRANULE | ORAL | 9717740 | Nov. 19, 2032 | TREATMENT OF ADRENAL INSUFFICIENCY |
5MG | ALKINDI SPRINKLE | ETON | N213876 | Sept. 29, 2020 | RX | GRANULE | ORAL | 9717740 | Nov. 19, 2032 | TREATMENT OF ADRENAL INSUFFICIENCY |
0.5MG | ALKINDI SPRINKLE | ETON | N213876 | Sept. 29, 2020 | RX | GRANULE | ORAL | 9675559 | Jan. 10, 2033 | TREATMENT OF ADRENAL INSUFFICIENCY |
1MG | ALKINDI SPRINKLE | ETON | N213876 | Sept. 29, 2020 | RX | GRANULE | ORAL | 9675559 | Jan. 10, 2033 | TREATMENT OF ADRENAL INSUFFICIENCY |
2MG | ALKINDI SPRINKLE | ETON | N213876 | Sept. 29, 2020 | RX | GRANULE | ORAL | 9675559 | Jan. 10, 2033 | TREATMENT OF ADRENAL INSUFFICIENCY |
5MG | ALKINDI SPRINKLE | ETON | N213876 | Sept. 29, 2020 | RX | GRANULE | ORAL | 9675559 | Jan. 10, 2033 | TREATMENT OF ADRENAL INSUFFICIENCY |
0.5MG | ALKINDI SPRINKLE | ETON | N213876 | Sept. 29, 2020 | RX | GRANULE | ORAL | 9649280 | May 12, 2034 | TREATMENT OF ADRENAL INSUFFICIENCY |
1MG | ALKINDI SPRINKLE | ETON | N213876 | Sept. 29, 2020 | RX | GRANULE | ORAL | 9649280 | May 12, 2034 | TREATMENT OF ADRENAL INSUFFICIENCY |
2MG | ALKINDI SPRINKLE | ETON | N213876 | Sept. 29, 2020 | RX | GRANULE | ORAL | 9649280 | May 12, 2034 | TREATMENT OF ADRENAL INSUFFICIENCY |
5MG | ALKINDI SPRINKLE | ETON | N213876 | Sept. 29, 2020 | RX | GRANULE | ORAL | 9649280 | May 12, 2034 | TREATMENT OF ADRENAL INSUFFICIENCY |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | EC50 | 8.50 | WOMBAT-PK | CHEMBL | |||
Annexin A1 | Cytosolic other | WOMBAT-PK | |||||||
Mineralocorticoid receptor | Nuclear hormone receptor | AGONIST | IC50 | 9.95 | IUPHAR | ||||
Nitric oxide synthase, inducible | Enzyme | IC50 | 8 | WOMBAT-PK | |||||
Corticosteroid-binding globulin | Secreted | Ki | 7.88 | WOMBAT-PK | |||||
Sex hormone-binding globulin | Secreted | Kd | 6.20 | CHEMBL | |||||
Glucocorticoid receptor | Transcription factor | IC50 | 7.60 | CHEMBL | |||||
Glucocorticoid receptor | Transcription factor | Kd | 7.37 | CHEMBL |
ID | Source |
---|---|
4017941 | VUID |
N0000146291 | NUI |
D00088 | KEGG_DRUG |
4017941 | VANDF |
C0020268 | UMLSCUI |
CHEBI:17650 | CHEBI |
HCY | PDB_CHEM_ID |
CHEMBL389621 | ChEMBL_ID |
DB00741 | DRUGBANK_ID |
D006854 | MESH_DESCRIPTOR_UI |
5754 | PUBCHEM_CID |
38 | INN_ID |
WI4X0X7BPJ | UNII |
202643 | RXNORM |
174 | MMSL |
2500 | MMSL |
4837 | MMSL |
d00254 | MMSL |
002147 | NDDF |
16602005 | SNOMEDCT_US |
396458002 | SNOMEDCT_US |
2868 | IUPHAR_LIGAND_ID |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
CORTEF | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0012 | TABLET | 5 mg | ORAL | NDA | 15 sections |
CORTEF | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0012 | TABLET | 5 mg | ORAL | NDA | 15 sections |
CORTEF | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0031 | TABLET | 10 mg | ORAL | NDA | 15 sections |
CORTEF | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0031 | TABLET | 10 mg | ORAL | NDA | 15 sections |
CORTEF | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0044 | TABLET | 20 mg | ORAL | NDA | 15 sections |
CORTEF | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0044 | TABLET | 20 mg | ORAL | NDA | 15 sections |
CIPROHC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0065-8531 | SUSPENSION | 10 mg | AURICULAR (OTIC) | NDA | 16 sections |
CIPROHC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0065-8531 | SUSPENSION | 10 mg | AURICULAR (OTIC) | NDA | 16 sections |
CIPROHC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0855 | SUSPENSION/ DROPS | 10 mg | AURICULAR (OTIC) | NDA | 16 sections |
CIPROHC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0855 | SUSPENSION/ DROPS | 10 mg | AURICULAR (OTIC) | NDA | 16 sections |
Aquanil HC | HUMAN OTC DRUG LABEL | 1 | 0096-0732 | LOTION | 0.01 g | TOPICAL | OTC monograph not final | 10 sections |
Aquanil HC | HUMAN OTC DRUG LABEL | 1 | 0096-0732 | LOTION | 0.01 g | TOPICAL | OTC monograph not final | 10 sections |
Good Sense Anti Itch | HUMAN OTC DRUG LABEL | 1 | 0113-0471 | OINTMENT | 1 g | TOPICAL | OTC monograph not final | 13 sections |
good sense anti itch | HUMAN OTC DRUG LABEL | 1 | 0113-0541 | CREAM | 1 g | TOPICAL | OTC monograph not final | 13 sections |
basic care hydrocortisone | HUMAN OTC DRUG LABEL | 1 | 0113-0793 | CREAM | 1 g | TOPICAL | OTC monograph not final | 13 sections |
Good Sense Anti Itch | HUMAN OTC DRUG LABEL | 1 | 0113-0973 | CREAM | 1 g | TOPICAL | OTC monograph not final | 13 sections |
Good Sense Anti Itch | HUMAN OTC DRUG LABEL | 1 | 0113-0973 | CREAM | 1 g | TOPICAL | OTC monograph not final | 13 sections |
good sense anti itch | HUMAN OTC DRUG LABEL | 1 | 0113-1369 | CREAM | 1 g | TOPICAL | OTC monograph not final | 13 sections |
Basic Case Hydrocortisone Anti-Itch | HUMAN OTC DRUG LABEL | 1 | 0113-7006 | CREAM | 1 g | TOPICAL | OTC monograph not final | 13 sections |
basic care hydrocortisone | HUMAN OTC DRUG LABEL | 1 | 0113-7369 | CREAM | 1 g | TOPICAL | OTC monograph not final | 13 sections |
HYDROCORTISONE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1696 | TABLET | 5 mg | ORAL | ANDA | 14 sections |
HYDROCORTISONE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1696 | TABLET | 5 mg | ORAL | ANDA | 14 sections |
HYDROCORTISONE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1697 | TABLET | 10 mg | ORAL | ANDA | 14 sections |
HYDROCORTISONE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1697 | TABLET | 10 mg | ORAL | ANDA | 14 sections |
HYDROCORTISONE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1700 | TABLET | 20 mg | ORAL | ANDA | 14 sections |
HYDROCORTISONE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1700 | TABLET | 20 mg | ORAL | ANDA | 14 sections |
HYDROCORTISONE | HUMAN OTC DRUG LABEL | 1 | 0168-0014 | CREAM | 5 mg | TOPICAL | OTC monograph final | 9 sections |
hydrocortisone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0015 | CREAM | 10 mg | TOPICAL | ANDA | 19 sections |
HYDROCORTISONE | HUMAN OTC DRUG LABEL | 1 | 0168-0016 | OINTMENT | 5 mg | TOPICAL | OTC monograph final | 9 sections |
Hydrocortisone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0020 | OINTMENT | 10 mg | TOPICAL | ANDA | 18 sections |