Stem definition | Drug id | CAS RN |
---|---|---|
diuretics, chlorothiazide derivatives | 1385 | 58-93-5 |
Dose | Unit | Route |
---|---|---|
25 | mg | O |
25 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.72 mg/mL | Bocci G, Oprea TI, Benet LZ |
EoM (Fraction excreted unchanged in urine) | 100 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 11.18 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 71 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
fu (Fraction unbound in plasma) | 0.56 % | Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K |
Date | Agency | Company | Orphan |
---|---|---|---|
Feb. 12, 1959 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hyponatraemia | 1225.56 | 9.85 | 1786 | 236089 | 110114 | 63141033 |
Pemphigus | 616.93 | 9.85 | 15 | 237860 | 183711 | 63067436 |
Maternal exposure during pregnancy | 538.52 | 9.85 | 89 | 237786 | 219973 | 63031174 |
Hypokalaemia | 529.96 | 9.85 | 1189 | 236686 | 102615 | 63148532 |
Hand deformity | 487.51 | 9.85 | 27 | 237848 | 159430 | 63091717 |
Systemic lupus erythematosus | 469.81 | 9.85 | 104 | 237771 | 208814 | 63042333 |
Glossodynia | 445.09 | 9.85 | 69 | 237806 | 178807 | 63072340 |
Contraindicated product administered | 345.16 | 9.85 | 193 | 237682 | 217455 | 63033692 |
Synovitis | 322.93 | 9.85 | 148 | 237727 | 186770 | 63064377 |
Off label use | 321.10 | 9.85 | 1370 | 236505 | 673092 | 62578055 |
Acute kidney injury | 312.39 | 9.85 | 1868 | 236007 | 261547 | 62989600 |
Duodenal ulcer perforation | 301.07 | 9.85 | 5 | 237870 | 87204 | 63163943 |
Blood pressure increased | 298.62 | 9.85 | 1301 | 236574 | 160761 | 63090386 |
Pericarditis | 279.02 | 9.85 | 74 | 237801 | 131505 | 63119642 |
Treatment failure | 276.64 | 9.85 | 205 | 237670 | 198838 | 63052309 |
Exposure during pregnancy | 273.60 | 9.85 | 120 | 237755 | 155427 | 63095720 |
Wound | 271.69 | 9.85 | 136 | 237739 | 163127 | 63088020 |
Drug intolerance | 265.18 | 9.85 | 469 | 237406 | 308192 | 62942955 |
Alopecia | 243.03 | 9.85 | 568 | 237307 | 336968 | 62914179 |
Myocardial infarction | 240.34 | 9.85 | 872 | 237003 | 99021 | 63152126 |
Blood potassium decreased | 237.75 | 9.85 | 502 | 237373 | 41524 | 63209623 |
Arthropathy | 228.75 | 9.85 | 328 | 237547 | 234464 | 63016683 |
Drug ineffective | 226.22 | 9.85 | 2670 | 235205 | 1042095 | 62209052 |
Cerebrovascular accident | 222.10 | 9.85 | 897 | 236978 | 107127 | 63144020 |
Discomfort | 217.90 | 9.85 | 184 | 237691 | 167190 | 63083957 |
Lower respiratory tract infection | 208.65 | 9.85 | 118 | 237757 | 132189 | 63118958 |
Angioedema | 206.10 | 9.85 | 514 | 237361 | 47451 | 63203696 |
Rheumatoid factor positive | 189.61 | 9.85 | 42 | 237833 | 84364 | 63166783 |
Dehydration | 178.24 | 9.85 | 1186 | 236689 | 172168 | 63078979 |
Muscle injury | 177.37 | 9.85 | 19 | 237856 | 65326 | 63185821 |
Folliculitis | 175.07 | 9.85 | 27 | 237848 | 70290 | 63180857 |
Helicobacter infection | 173.82 | 9.85 | 65 | 237810 | 92720 | 63158427 |
Macular degeneration | 162.73 | 9.85 | 312 | 237563 | 24064 | 63227083 |
Sleep disorder due to general medical condition, insomnia type | 162.14 | 9.85 | 8 | 237867 | 52209 | 63198938 |
Abdominal discomfort | 161.96 | 9.85 | 636 | 237239 | 320249 | 62930898 |
Product use issue | 161.85 | 9.85 | 367 | 237508 | 220153 | 63030994 |
Dizziness | 159.56 | 9.85 | 2376 | 235499 | 427549 | 62823598 |
Coronary artery disease | 157.40 | 9.85 | 364 | 237511 | 32013 | 63219134 |
Syncope | 151.55 | 9.85 | 852 | 237023 | 116533 | 63134614 |
Infusion related reaction | 150.04 | 9.85 | 448 | 237427 | 245073 | 63006074 |
Swelling | 149.91 | 9.85 | 529 | 237346 | 274849 | 62976298 |
Blood pressure inadequately controlled | 144.99 | 9.85 | 132 | 237743 | 4846 | 63246301 |
Eosinophilic bronchitis | 141.97 | 9.85 | 60 | 237815 | 513 | 63250634 |
Therapeutic product effect decreased | 141.34 | 9.85 | 322 | 237553 | 192865 | 63058282 |
Joint swelling | 138.41 | 9.85 | 694 | 237181 | 326972 | 62924175 |
Inappropriate antidiuretic hormone secretion | 135.57 | 9.85 | 223 | 237652 | 15239 | 63235908 |
Condition aggravated | 131.73 | 9.85 | 924 | 236951 | 401293 | 62849854 |
Blister | 130.66 | 9.85 | 177 | 237698 | 129637 | 63121510 |
Infection | 129.59 | 9.85 | 433 | 237442 | 228740 | 63022407 |
Irritable bowel syndrome | 127.76 | 9.85 | 75 | 237800 | 82337 | 63168810 |
Lactic acidosis | 124.14 | 9.85 | 370 | 237505 | 37917 | 63213230 |
Transient ischaemic attack | 121.61 | 9.85 | 364 | 237511 | 37389 | 63213758 |
Hepatic enzyme increased | 119.43 | 9.85 | 375 | 237500 | 201953 | 63049194 |
Fall | 116.30 | 9.85 | 2090 | 235785 | 390244 | 62860903 |
Hypotension | 113.91 | 9.85 | 1539 | 236336 | 271065 | 62980082 |
Blood glucose increased | 111.45 | 9.85 | 613 | 237262 | 83143 | 63168004 |
Asthenia | 108.96 | 9.85 | 2030 | 235845 | 381574 | 62869573 |
Gastrooesophageal reflux disease | 107.21 | 9.85 | 669 | 237206 | 94970 | 63156177 |
Drug abuse | 106.85 | 9.85 | 70 | 237805 | 72448 | 63178699 |
Impaired healing | 104.00 | 9.85 | 139 | 237736 | 102403 | 63148744 |
Abortion spontaneous | 99.13 | 9.85 | 27 | 237848 | 47168 | 63203979 |
Product use in unapproved indication | 93.41 | 9.85 | 350 | 237525 | 178730 | 63072417 |
Blood sodium decreased | 90.92 | 9.85 | 247 | 237628 | 24005 | 63227142 |
Sprue-like enteropathy | 88.63 | 9.85 | 47 | 237828 | 696 | 63250451 |
Mobility decreased | 84.53 | 9.85 | 207 | 237668 | 120952 | 63130195 |
Death | 84.50 | 9.85 | 946 | 236929 | 373435 | 62877712 |
Palpitations | 83.83 | 9.85 | 715 | 237160 | 112055 | 63139092 |
Intentional product use issue | 82.71 | 9.85 | 227 | 237648 | 127665 | 63123482 |
Hypertension | 80.91 | 9.85 | 1483 | 236392 | 277820 | 62973327 |
Renal failure | 80.75 | 9.85 | 733 | 237142 | 116919 | 63134228 |
Hip arthroplasty | 80.23 | 9.85 | 39 | 237836 | 47607 | 63203540 |
Chest pain | 79.64 | 9.85 | 1193 | 236682 | 214766 | 63036381 |
Live birth | 79.33 | 9.85 | 4 | 237871 | 25626 | 63225521 |
Lung diffusion test abnormal | 78.66 | 9.85 | 34 | 237841 | 309 | 63250838 |
Cardiac failure congestive | 77.86 | 9.85 | 603 | 237272 | 91830 | 63159317 |
Hypertensive crisis | 77.77 | 9.85 | 175 | 237700 | 15111 | 63236036 |
Oedema peripheral | 77.47 | 9.85 | 1066 | 236809 | 188445 | 63062702 |
Hypersensitivity | 76.97 | 9.85 | 713 | 237162 | 291972 | 62959175 |
Stomatitis | 76.38 | 9.85 | 265 | 237610 | 138460 | 63112687 |
C-reactive protein abnormal | 74.24 | 9.85 | 40 | 237835 | 46056 | 63205091 |
Hypochloraemia | 74.17 | 9.85 | 61 | 237814 | 1948 | 63249199 |
Pain | 73.86 | 9.85 | 2163 | 235712 | 738465 | 62512682 |
Pregnancy | 73.83 | 9.85 | 23 | 237852 | 36813 | 63214334 |
Ill-defined disorder | 73.00 | 9.85 | 121 | 237754 | 81634 | 63169513 |
Rash | 71.98 | 9.85 | 1578 | 236297 | 559293 | 62691854 |
Therapy non-responder | 71.88 | 9.85 | 108 | 237767 | 75793 | 63175354 |
Angina pectoris | 70.94 | 9.85 | 261 | 237614 | 29817 | 63221330 |
Blood urea increased | 70.92 | 9.85 | 239 | 237636 | 26140 | 63225007 |
Intentional self-injury | 70.91 | 9.85 | 7 | 237868 | 25680 | 63225467 |
Pancreatitis acute | 69.42 | 9.85 | 242 | 237633 | 26924 | 63224223 |
Liver injury | 65.56 | 9.85 | 78 | 237797 | 60442 | 63190705 |
Cardiospasm | 64.40 | 9.85 | 55 | 237820 | 1852 | 63249295 |
Psoriatic arthropathy | 64.11 | 9.85 | 156 | 237719 | 91364 | 63159783 |
Polyp | 63.97 | 9.85 | 99 | 237776 | 6422 | 63244725 |
Drug interaction | 63.68 | 9.85 | 1209 | 236666 | 227922 | 63023225 |
Atrial tachycardia | 63.61 | 9.85 | 79 | 237796 | 4161 | 63246986 |
Hypovolaemia | 63.27 | 9.85 | 130 | 237745 | 10543 | 63240604 |
Palmoplantar keratoderma | 61.96 | 9.85 | 55 | 237820 | 1952 | 63249195 |
Blood pressure diastolic decreased | 61.28 | 9.85 | 206 | 237669 | 22500 | 63228647 |
Loss of employment | 60.51 | 9.85 | 57 | 237818 | 2187 | 63248960 |
Gastrointestinal disorder | 59.36 | 9.85 | 271 | 237604 | 130968 | 63120179 |
Product complaint | 57.90 | 9.85 | 140 | 237735 | 12669 | 63238478 |
Myelosuppression | 56.98 | 9.85 | 10 | 237865 | 23693 | 63227454 |
Hypertensive emergency | 56.97 | 9.85 | 51 | 237824 | 1831 | 63249316 |
Hyperkalaemia | 56.91 | 9.85 | 373 | 237502 | 53830 | 63197317 |
Blood creatinine increased | 56.59 | 9.85 | 540 | 237335 | 87304 | 63163843 |
Hypoglycaemia | 56.33 | 9.85 | 402 | 237473 | 59663 | 63191484 |
Nausea | 55.81 | 9.85 | 3813 | 234062 | 850658 | 62400489 |
Red blood cell sedimentation rate abnormal | 55.65 | 9.85 | 5 | 237870 | 19777 | 63231370 |
Febrile neutropenia | 55.13 | 9.85 | 242 | 237633 | 118207 | 63132940 |
Carotid artery occlusion | 54.30 | 9.85 | 77 | 237798 | 4617 | 63246530 |
Atrial fibrillation | 54.29 | 9.85 | 672 | 237203 | 115964 | 63135183 |
Pruritus genital | 54.23 | 9.85 | 58 | 237817 | 2596 | 63248551 |
Blood pressure systolic increased | 52.12 | 9.85 | 330 | 237545 | 47067 | 63204080 |
Neutropenia | 51.45 | 9.85 | 414 | 237461 | 174591 | 63076556 |
Sinus bradycardia | 51.37 | 9.85 | 145 | 237730 | 14406 | 63236741 |
Disease progression | 51.15 | 9.85 | 261 | 237614 | 122497 | 63128650 |
Sleep terror | 50.29 | 9.85 | 56 | 237819 | 2624 | 63248523 |
Cytomegalovirus infection | 50.02 | 9.85 | 9 | 237866 | 20943 | 63230204 |
Disorientation | 49.31 | 9.85 | 284 | 237591 | 39168 | 63211979 |
Angina unstable | 48.81 | 9.85 | 92 | 237783 | 7003 | 63244144 |
Toxicity to various agents | 48.76 | 9.85 | 643 | 237232 | 246607 | 63004540 |
Diabetes mellitus | 47.48 | 9.85 | 365 | 237510 | 55445 | 63195702 |
Malignant neoplasm progression | 47.15 | 9.85 | 154 | 237721 | 81967 | 63169180 |
Arterial occlusive disease | 47.02 | 9.85 | 82 | 237793 | 5876 | 63245271 |
Recalled product | 46.44 | 9.85 | 40 | 237835 | 1363 | 63249784 |
Drug resistance | 44.75 | 9.85 | 15 | 237860 | 22918 | 63228229 |
Cataract | 44.64 | 9.85 | 366 | 237509 | 56687 | 63194460 |
Feeling abnormal | 44.33 | 9.85 | 792 | 237083 | 147600 | 63103547 |
Musculoskeletal stiffness | 44.17 | 9.85 | 460 | 237415 | 184158 | 63066989 |
Hypercalcaemia | 42.96 | 9.85 | 215 | 237660 | 28107 | 63223040 |
Anosmia | 42.38 | 9.85 | 85 | 237790 | 6775 | 63244372 |
Premature delivery | 42.25 | 9.85 | 31 | 237844 | 30250 | 63220897 |
Tension headache | 41.74 | 9.85 | 72 | 237803 | 5114 | 63246033 |
Neutrophil count decreased | 40.41 | 9.85 | 95 | 237780 | 56311 | 63194836 |
Hepatic function abnormal | 40.09 | 9.85 | 48 | 237827 | 37094 | 63214053 |
Fibromyalgia | 40.08 | 9.85 | 160 | 237715 | 80260 | 63170887 |
Facial pain | 40.02 | 9.85 | 108 | 237767 | 10453 | 63240694 |
Immunisation | 39.46 | 9.85 | 34 | 237841 | 1159 | 63249988 |
Milk-alkali syndrome | 38.92 | 9.85 | 29 | 237846 | 799 | 63250348 |
Large intestine polyp | 38.86 | 9.85 | 91 | 237784 | 8066 | 63243081 |
Pneumonia aspiration | 38.29 | 9.85 | 241 | 237634 | 34299 | 63216848 |
Intentional overdose | 37.93 | 9.85 | 146 | 237729 | 74006 | 63177141 |
Hyperlipidaemia | 37.41 | 9.85 | 159 | 237716 | 19412 | 63231735 |
Neutrophilia | 36.56 | 9.85 | 62 | 237813 | 4344 | 63246803 |
Hospitalisation | 36.52 | 9.85 | 179 | 237696 | 84902 | 63166245 |
Pancreatitis | 36.41 | 9.85 | 311 | 237564 | 48744 | 63202403 |
Peripheral swelling | 36.39 | 9.85 | 740 | 237135 | 265202 | 62985945 |
Ventricular hypertrophy | 36.30 | 9.85 | 54 | 237821 | 3382 | 63247765 |
Nasopharyngitis | 35.84 | 9.85 | 704 | 237171 | 253553 | 62997594 |
Subarachnoid haemorrhage | 35.42 | 9.85 | 126 | 237749 | 14157 | 63236990 |
Rheumatoid arthritis | 35.11 | 9.85 | 705 | 237170 | 253114 | 62998033 |
Prescribed overdose | 34.91 | 9.85 | 46 | 237829 | 34107 | 63217040 |
Obstructive airways disorder | 34.90 | 9.85 | 162 | 237713 | 20537 | 63230610 |
Allergic oedema | 34.52 | 9.85 | 27 | 237848 | 801 | 63250346 |
Hyperhidrosis | 34.52 | 9.85 | 582 | 237293 | 107254 | 63143893 |
Pyrexia | 34.46 | 9.85 | 1427 | 236448 | 469051 | 62782096 |
Conjoined twins | 34.21 | 9.85 | 18 | 237857 | 262 | 63250885 |
Pemphigoid | 33.98 | 9.85 | 81 | 237794 | 7263 | 63243884 |
Heart rate irregular | 33.86 | 9.85 | 170 | 237705 | 22251 | 63228896 |
Gastric disorder | 33.82 | 9.85 | 248 | 237627 | 37121 | 63214026 |
Hepatic steatosis | 33.31 | 9.85 | 203 | 237672 | 28566 | 63222581 |
Weight decreased | 33.04 | 9.85 | 1309 | 236566 | 275489 | 62975658 |
Sedation complication | 32.86 | 9.85 | 6 | 237869 | 13816 | 63237331 |
Bradycardia | 32.40 | 9.85 | 418 | 237457 | 72809 | 63178338 |
Cough | 32.33 | 9.85 | 1373 | 236502 | 291370 | 62959777 |
Blood chloride decreased | 32.26 | 9.85 | 67 | 237808 | 5475 | 63245672 |
Rhabdomyolysis | 31.76 | 9.85 | 277 | 237598 | 43674 | 63207473 |
Arrhythmia | 31.64 | 9.85 | 248 | 237627 | 37892 | 63213255 |
Mitral valve incompetence | 31.32 | 9.85 | 151 | 237724 | 19443 | 63231704 |
Adverse drug reaction | 31.24 | 9.85 | 173 | 237702 | 79541 | 63171606 |
Intestinal angioedema | 30.92 | 9.85 | 23 | 237852 | 632 | 63250515 |
Device expulsion | 30.87 | 9.85 | 52 | 237823 | 34870 | 63216277 |
Leukopenia | 30.69 | 9.85 | 167 | 237708 | 77123 | 63174024 |
Swollen tongue | 30.39 | 9.85 | 229 | 237646 | 34571 | 63216576 |
Product monitoring error | 30.38 | 9.85 | 58 | 237817 | 4458 | 63246689 |
Pneumonia | 29.82 | 9.85 | 1403 | 236472 | 455364 | 62795783 |
Knee arthroplasty | 29.51 | 9.85 | 104 | 237771 | 54102 | 63197045 |
Atrioventricular block first degree | 29.21 | 9.85 | 76 | 237799 | 7197 | 63243950 |
Acute myeloid leukaemia | 28.92 | 9.85 | 14 | 237861 | 17133 | 63234014 |
Mental status changes | 28.83 | 9.85 | 250 | 237625 | 39349 | 63211798 |
Arteriosclerosis | 28.66 | 9.85 | 93 | 237782 | 9973 | 63241174 |
Myalgia | 28.53 | 9.85 | 735 | 237140 | 145794 | 63105353 |
Anxiety | 28.14 | 9.85 | 1038 | 236837 | 216503 | 63034644 |
Electrolyte imbalance | 28.08 | 9.85 | 149 | 237726 | 19927 | 63231220 |
Device related thrombosis | 27.98 | 9.85 | 34 | 237841 | 1751 | 63249396 |
Foetal death | 27.82 | 9.85 | 4 | 237871 | 10976 | 63240171 |
Muscle spasms | 27.75 | 9.85 | 774 | 237101 | 155376 | 63095771 |
Blood creatine phosphokinase increased | 27.57 | 9.85 | 202 | 237673 | 30228 | 63220919 |
Electrocardiogram abnormal | 27.22 | 9.85 | 86 | 237789 | 9093 | 63242054 |
Essential hypertension | 27.16 | 9.85 | 59 | 237816 | 4974 | 63246173 |
Joint range of motion decreased | 27.12 | 9.85 | 50 | 237825 | 32378 | 63218769 |
Product prescribing error | 27.04 | 9.85 | 180 | 237695 | 26109 | 63225038 |
Rotator cuff syndrome | 26.82 | 9.85 | 111 | 237764 | 13391 | 63237756 |
Suicide attempt | 26.81 | 9.85 | 127 | 237748 | 60791 | 63190356 |
Gangrene | 26.69 | 9.85 | 66 | 237809 | 6057 | 63245090 |
Haemophagocytic lymphohistiocytosis | 26.63 | 9.85 | 4 | 237871 | 10623 | 63240524 |
Bone marrow failure | 26.46 | 9.85 | 43 | 237832 | 29247 | 63221900 |
Poisoning deliberate | 26.39 | 9.85 | 5 | 237870 | 11213 | 63239934 |
Ventricular extrasystoles | 26.38 | 9.85 | 100 | 237775 | 11587 | 63239560 |
Supraventricular extrasystoles | 26.15 | 9.85 | 55 | 237820 | 4534 | 63246613 |
Product substitution issue | 26.10 | 9.85 | 124 | 237751 | 15872 | 63235275 |
Carotid artery stenosis | 26.09 | 9.85 | 59 | 237816 | 5111 | 63246036 |
Congenital bladder anomaly | 25.87 | 9.85 | 13 | 237862 | 171 | 63250976 |
Respiratory tract inflammation | 25.84 | 9.85 | 20 | 237855 | 584 | 63250563 |
Erythrodermic psoriasis | 25.82 | 9.85 | 25 | 237850 | 993 | 63250154 |
Depression | 25.52 | 9.85 | 938 | 236937 | 195554 | 63055593 |
Withdrawal hypertension | 25.45 | 9.85 | 12 | 237863 | 136 | 63251011 |
Coma | 25.43 | 9.85 | 360 | 237515 | 64004 | 63187143 |
Urachal abnormality | 25.35 | 9.85 | 13 | 237862 | 179 | 63250968 |
Sepsis | 25.02 | 9.85 | 413 | 237462 | 152710 | 63098437 |
Persistent cloaca | 24.54 | 9.85 | 13 | 237862 | 192 | 63250955 |
Non-cardiogenic pulmonary oedema | 24.52 | 9.85 | 21 | 237854 | 710 | 63250437 |
Systemic infection | 24.43 | 9.85 | 54 | 237821 | 4606 | 63246541 |
Foetal exposure during pregnancy | 24.39 | 9.85 | 52 | 237823 | 31910 | 63219237 |
Chronic sinusitis | 24.28 | 9.85 | 104 | 237771 | 12739 | 63238408 |
Sinusitis | 24.20 | 9.85 | 655 | 237220 | 225998 | 63025149 |
Cardiac disorder | 24.16 | 9.85 | 294 | 237581 | 50522 | 63200625 |
Emotional distress | 23.96 | 9.85 | 206 | 237669 | 32343 | 63218804 |
Insomnia | 23.84 | 9.85 | 1010 | 236865 | 214242 | 63036905 |
Nervousness | 23.83 | 9.85 | 198 | 237677 | 30781 | 63220366 |
Abnormal dreams | 23.75 | 9.85 | 90 | 237785 | 10426 | 63240721 |
Breast cancer stage III | 23.66 | 9.85 | 5 | 237870 | 10381 | 63240766 |
Platelet count decreased | 23.59 | 9.85 | 300 | 237575 | 115822 | 63135325 |
C-reactive protein increased | 23.45 | 9.85 | 234 | 237641 | 94473 | 63156674 |
Hyperglycaemia | 23.40 | 9.85 | 250 | 237625 | 41617 | 63209530 |
Visual acuity reduced | 23.39 | 9.85 | 151 | 237724 | 21675 | 63229472 |
Anhedonia | 23.22 | 9.85 | 92 | 237783 | 10882 | 63240265 |
Heart rate decreased | 23.16 | 9.85 | 267 | 237608 | 45293 | 63205854 |
Neurosensory hypoacusis | 23.14 | 9.85 | 13 | 237862 | 217 | 63250930 |
Hypersensitivity vasculitis | 23.10 | 9.85 | 49 | 237826 | 4063 | 63247084 |
Diabetes mellitus inadequate control | 23.06 | 9.85 | 115 | 237760 | 15011 | 63236136 |
Hepatotoxicity | 23.00 | 9.85 | 67 | 237808 | 36974 | 63214173 |
Nephrocalcinosis | 22.81 | 9.85 | 24 | 237851 | 1054 | 63250093 |
Grip strength decreased | 22.80 | 9.85 | 30 | 237845 | 22257 | 63228890 |
Urinary incontinence | 22.73 | 9.85 | 201 | 237674 | 31813 | 63219334 |
Rhinalgia | 22.73 | 9.85 | 29 | 237846 | 1570 | 63249577 |
Bundle branch block left | 22.67 | 9.85 | 68 | 237807 | 6991 | 63244156 |
Hypocalcaemia | 22.46 | 9.85 | 199 | 237676 | 31514 | 63219633 |
Blood pressure decreased | 22.31 | 9.85 | 355 | 237520 | 64667 | 63186480 |
Oropharyngeal swelling | 22.21 | 9.85 | 22 | 237853 | 899 | 63250248 |
Intestinal villi atrophy | 22.13 | 9.85 | 13 | 237862 | 237 | 63250910 |
Atrioventricular block | 22.09 | 9.85 | 71 | 237804 | 7576 | 63243571 |
Myocardial ischaemia | 21.95 | 9.85 | 101 | 237774 | 12758 | 63238389 |
Tinnitus | 21.94 | 9.85 | 217 | 237658 | 35411 | 63215736 |
Facet joint syndrome | 21.90 | 9.85 | 9 | 237866 | 12129 | 63239018 |
Diverticulum | 21.83 | 9.85 | 96 | 237779 | 11895 | 63239252 |
Coronary artery occlusion | 21.82 | 9.85 | 74 | 237801 | 8117 | 63243030 |
Psoriasis | 21.82 | 9.85 | 452 | 237423 | 86505 | 63164642 |
Intestinal malrotation | 21.75 | 9.85 | 15 | 237860 | 365 | 63250782 |
Type 2 diabetes mellitus | 21.67 | 9.85 | 145 | 237730 | 63723 | 63187424 |
Neutropenic sepsis | 21.45 | 9.85 | 18 | 237857 | 16420 | 63234727 |
Dysgeusia | 21.24 | 9.85 | 268 | 237607 | 46442 | 63204705 |
Heart rate increased | 21.14 | 9.85 | 482 | 237393 | 93756 | 63157391 |
Distributive shock | 21.12 | 9.85 | 26 | 237849 | 1357 | 63249790 |
Paraesthesia oral | 21.12 | 9.85 | 134 | 237741 | 19122 | 63232025 |
Drug hypersensitivity | 21.11 | 9.85 | 950 | 236925 | 309737 | 62941410 |
Gout | 21.02 | 9.85 | 102 | 237773 | 13169 | 63237978 |
Overdose | 20.96 | 9.85 | 304 | 237571 | 114774 | 63136373 |
Glycosylated haemoglobin increased | 20.88 | 9.85 | 97 | 237778 | 12301 | 63238846 |
Somnolence | 20.83 | 9.85 | 843 | 237032 | 177842 | 63073305 |
Therapy partial responder | 20.75 | 9.85 | 7 | 237868 | 10651 | 63240496 |
Orthostatic intolerance | 20.74 | 9.85 | 24 | 237851 | 1173 | 63249974 |
Acute coronary syndrome | 20.71 | 9.85 | 84 | 237791 | 10042 | 63241105 |
Electrocardiogram ST segment depression | 20.66 | 9.85 | 38 | 237837 | 2839 | 63248308 |
Eosinophilia | 20.58 | 9.85 | 151 | 237724 | 22605 | 63228542 |
Dry skin | 20.43 | 9.85 | 313 | 237562 | 56574 | 63194573 |
Bronchomalacia | 20.37 | 9.85 | 12 | 237863 | 220 | 63250927 |
Interstitial lung disease | 20.29 | 9.85 | 142 | 237733 | 61766 | 63189381 |
Pneumothorax spontaneous | 20.25 | 9.85 | 20 | 237855 | 814 | 63250333 |
Thrombocytopenia | 20.24 | 9.85 | 422 | 237453 | 150735 | 63100412 |
Pancytopenia | 20.22 | 9.85 | 249 | 237626 | 96684 | 63154463 |
Blindness | 20.20 | 9.85 | 145 | 237730 | 21554 | 63229593 |
Bladder prolapse | 20.13 | 9.85 | 32 | 237843 | 2124 | 63249023 |
Micturition disorder | 20.12 | 9.85 | 35 | 237840 | 2503 | 63248644 |
Osteonecrosis | 20.07 | 9.85 | 159 | 237716 | 24371 | 63226776 |
Adenocarcinoma | 19.98 | 9.85 | 38 | 237837 | 2912 | 63248235 |
Premature labour | 19.91 | 9.85 | 11 | 237864 | 12493 | 63238654 |
Epilepsy | 19.85 | 9.85 | 45 | 237830 | 27020 | 63224127 |
Septic shock | 19.85 | 9.85 | 157 | 237718 | 66472 | 63184675 |
Hypoparathyroidism | 19.79 | 9.85 | 18 | 237857 | 660 | 63250487 |
Cutaneous lupus erythematosus | 19.70 | 9.85 | 36 | 237839 | 2676 | 63248471 |
Device related infection | 19.62 | 9.85 | 36 | 237839 | 23356 | 63227791 |
Sopor | 19.59 | 9.85 | 33 | 237842 | 22131 | 63229016 |
Intervertebral disc protrusion | 19.57 | 9.85 | 154 | 237721 | 23555 | 63227592 |
Hypophagia | 19.55 | 9.85 | 191 | 237684 | 31068 | 63220079 |
Cholelithiasis | 19.54 | 9.85 | 251 | 237624 | 43674 | 63207473 |
Coronary artery stenosis | 19.49 | 9.85 | 50 | 237825 | 4694 | 63246453 |
Azotaemia | 19.28 | 9.85 | 48 | 237827 | 4423 | 63246724 |
Bacterial infection | 19.15 | 9.85 | 132 | 237743 | 19367 | 63231780 |
Metabolic alkalosis | 18.99 | 9.85 | 38 | 237837 | 3023 | 63248124 |
Diplopia | 18.98 | 9.85 | 153 | 237722 | 23575 | 63227572 |
Haemodialysis | 18.92 | 9.85 | 75 | 237800 | 8872 | 63242275 |
Pain of skin | 18.84 | 9.85 | 90 | 237785 | 11544 | 63239603 |
Polymyalgia rheumatica | 18.84 | 9.85 | 43 | 237832 | 3748 | 63247399 |
Tooth erosion | 18.81 | 9.85 | 15 | 237860 | 458 | 63250689 |
Cardiac stress test abnormal | 18.76 | 9.85 | 17 | 237858 | 620 | 63250527 |
Renal artery stenosis | 18.75 | 9.85 | 29 | 237846 | 1880 | 63249267 |
Autoimmune disorder | 18.75 | 9.85 | 22 | 237853 | 17155 | 63233992 |
Vitamin B1 decreased | 18.71 | 9.85 | 11 | 237864 | 201 | 63250946 |
Eye pruritus | 18.70 | 9.85 | 127 | 237748 | 18544 | 63232603 |
Ventricular fibrillation | 18.64 | 9.85 | 91 | 237784 | 11776 | 63239371 |
Pathological fracture | 18.64 | 9.85 | 74 | 237801 | 8760 | 63242387 |
Depressed level of consciousness | 18.62 | 9.85 | 146 | 237729 | 61932 | 63189215 |
Disturbance in attention | 18.61 | 9.85 | 222 | 237653 | 37967 | 63213180 |
Cyanopsia | 18.60 | 9.85 | 5 | 237870 | 7 | 63251140 |
Deep vein thrombosis | 18.60 | 9.85 | 428 | 237447 | 83372 | 63167775 |
Dysarthria | 18.55 | 9.85 | 243 | 237632 | 42468 | 63208679 |
Amnesia | 18.51 | 9.85 | 302 | 237573 | 55283 | 63195864 |
Neurofibrosarcoma | 18.51 | 9.85 | 10 | 237865 | 154 | 63250993 |
Liver function test increased | 18.50 | 9.85 | 62 | 237813 | 32749 | 63218398 |
Disability | 18.46 | 9.85 | 25 | 237850 | 18322 | 63232825 |
Mesenteric panniculitis | 18.42 | 9.85 | 9 | 237866 | 111 | 63251036 |
Small cell carcinoma | 18.40 | 9.85 | 10 | 237865 | 156 | 63250991 |
Hypertensive heart disease | 18.39 | 9.85 | 33 | 237842 | 2419 | 63248728 |
Hip fracture | 18.38 | 9.85 | 180 | 237695 | 29294 | 63221853 |
Cytokine release syndrome | 18.28 | 9.85 | 16 | 237859 | 14298 | 63236849 |
Sedation | 18.22 | 9.85 | 79 | 237796 | 38730 | 63212417 |
Tendon rupture | 18.18 | 9.85 | 70 | 237805 | 8169 | 63242978 |
Dysuria | 18.18 | 9.85 | 200 | 237675 | 33538 | 63217609 |
Pneumocystis jirovecii pneumonia | 18.10 | 9.85 | 22 | 237853 | 16892 | 63234255 |
Acute myocardial infarction | 18.04 | 9.85 | 192 | 237683 | 31932 | 63219215 |
Eosinophil count increased | 18.04 | 9.85 | 85 | 237790 | 10843 | 63240304 |
Bronchopulmonary aspergillosis | 18.02 | 9.85 | 5 | 237870 | 8630 | 63242517 |
Cutaneous T-cell lymphoma | 18.01 | 9.85 | 24 | 237851 | 1356 | 63249791 |
Pernicious anaemia | 17.94 | 9.85 | 17 | 237858 | 657 | 63250490 |
Transplant rejection | 17.88 | 9.85 | 9 | 237866 | 10771 | 63240376 |
Meniscus injury | 17.85 | 9.85 | 63 | 237812 | 7051 | 63244096 |
Body height decreased | 17.83 | 9.85 | 80 | 237795 | 9998 | 63241149 |
Parkinsonism | 17.82 | 9.85 | 82 | 237793 | 10357 | 63240790 |
Asthma | 17.79 | 9.85 | 614 | 237261 | 126947 | 63124200 |
Adjustment disorder with depressed mood | 17.72 | 9.85 | 8 | 237867 | 10196 | 63240951 |
Forced vital capacity decreased | 17.64 | 9.85 | 21 | 237854 | 1058 | 63250089 |
Lip swelling | 17.60 | 9.85 | 186 | 237689 | 30877 | 63220270 |
Muscular weakness | 17.59 | 9.85 | 591 | 237284 | 121762 | 63129385 |
Diverticulitis | 17.57 | 9.85 | 226 | 237649 | 39331 | 63211816 |
Tooth abscess | 17.57 | 9.85 | 106 | 237769 | 14863 | 63236284 |
Basal cell carcinoma | 17.49 | 9.85 | 171 | 237704 | 27820 | 63223327 |
Fear | 17.47 | 9.85 | 110 | 237765 | 15656 | 63235491 |
Hypertensive angiopathy | 17.42 | 9.85 | 8 | 237867 | 85 | 63251062 |
Peripheral vascular disorder | 17.40 | 9.85 | 56 | 237819 | 5979 | 63245168 |
Fear of injection | 17.27 | 9.85 | 3 | 237872 | 7161 | 63243986 |
Lacunar infarction | 17.19 | 9.85 | 38 | 237837 | 3242 | 63247905 |
Macular oedema | 17.12 | 9.85 | 42 | 237833 | 3835 | 63247312 |
Metastases to fallopian tube | 17.07 | 9.85 | 7 | 237868 | 55 | 63251092 |
Skin haemorrhage | 17.02 | 9.85 | 79 | 237796 | 10015 | 63241132 |
Skin exfoliation | 16.99 | 9.85 | 241 | 237634 | 42861 | 63208286 |
Schizophrenia | 16.98 | 9.85 | 8 | 237867 | 9944 | 63241203 |
Diarrhoea | 16.90 | 9.85 | 2985 | 234890 | 712381 | 62538766 |
Photosensitivity reaction | 16.85 | 9.85 | 105 | 237770 | 14889 | 63236258 |
Hyponatraemic encephalopathy | 16.80 | 9.85 | 11 | 237864 | 245 | 63250902 |
Back pain | 16.78 | 9.85 | 1177 | 236698 | 262968 | 62988179 |
Osteoarthritis | 16.76 | 9.85 | 472 | 237403 | 94871 | 63156276 |
Vulvovaginal burning sensation | 16.61 | 9.85 | 29 | 237846 | 2080 | 63249067 |
Rectal prolapse | 16.58 | 9.85 | 28 | 237847 | 1955 | 63249192 |
Breast cancer stage II | 16.55 | 9.85 | 6 | 237869 | 8730 | 63242417 |
Oesophageal discomfort | 16.52 | 9.85 | 10 | 237865 | 193 | 63250954 |
Breath sounds abnormal | 16.43 | 9.85 | 83 | 237792 | 10890 | 63240257 |
Endometrial cancer stage I | 16.37 | 9.85 | 11 | 237864 | 256 | 63250891 |
Injection site inflammation | 16.30 | 9.85 | 41 | 237834 | 3802 | 63247345 |
Adverse event | 16.27 | 9.85 | 168 | 237707 | 67391 | 63183756 |
Epstein-Barr virus infection | 16.18 | 9.85 | 5 | 237870 | 8045 | 63243102 |
Blood lactic acid decreased | 16.09 | 9.85 | 9 | 237866 | 149 | 63250998 |
Meniere's disease | 16.08 | 9.85 | 10 | 237865 | 203 | 63250944 |
Petechiae | 16.05 | 9.85 | 98 | 237777 | 13799 | 63237348 |
Dementia | 16.03 | 9.85 | 123 | 237752 | 18671 | 63232476 |
Bone erosion | 16.01 | 9.85 | 26 | 237849 | 17691 | 63233456 |
Acute myopia | 15.87 | 9.85 | 8 | 237867 | 106 | 63251041 |
Dystonia | 15.85 | 9.85 | 17 | 237858 | 13802 | 63237345 |
Rash papular | 15.84 | 9.85 | 107 | 237768 | 15595 | 63235552 |
Anaphylactic reaction | 15.67 | 9.85 | 165 | 237710 | 65935 | 63185212 |
Anti-neutrophil cytoplasmic antibody positive vasculitis | 15.66 | 9.85 | 34 | 237841 | 2865 | 63248282 |
Peripheral venous disease | 15.66 | 9.85 | 21 | 237854 | 15456 | 63235691 |
Vertigo | 15.58 | 9.85 | 313 | 237562 | 59574 | 63191573 |
Spinal osteoarthritis | 15.56 | 9.85 | 109 | 237766 | 16077 | 63235070 |
Hypertrophic cardiomyopathy | 15.44 | 9.85 | 24 | 237851 | 1563 | 63249584 |
Neurotoxicity | 15.29 | 9.85 | 25 | 237850 | 16965 | 63234182 |
Mucosal membrane hyperplasia | 15.23 | 9.85 | 6 | 237869 | 42 | 63251105 |
Polydipsia | 15.10 | 9.85 | 38 | 237837 | 3526 | 63247621 |
Amaurosis fugax | 15.09 | 9.85 | 13 | 237862 | 443 | 63250704 |
Ventricular tachycardia | 15.00 | 9.85 | 127 | 237748 | 19852 | 63231295 |
Extrasystoles | 14.99 | 9.85 | 48 | 237827 | 5112 | 63246035 |
Coronary ostial stenosis | 14.95 | 9.85 | 7 | 237868 | 78 | 63251069 |
Cardiac hypertrophy | 14.93 | 9.85 | 19 | 237856 | 1026 | 63250121 |
Mandibular mass | 14.90 | 9.85 | 9 | 237866 | 173 | 63250974 |
Procalcitonin increased | 14.89 | 9.85 | 20 | 237855 | 1139 | 63250008 |
Hypomagnesaemia | 14.87 | 9.85 | 169 | 237706 | 28568 | 63222579 |
Dysphagia | 14.87 | 9.85 | 436 | 237439 | 88149 | 63162998 |
Jaw disorder | 14.85 | 9.85 | 49 | 237826 | 5300 | 63245847 |
Low density lipoprotein increased | 14.85 | 9.85 | 55 | 237820 | 6302 | 63244845 |
Carotid bruit | 14.84 | 9.85 | 16 | 237859 | 723 | 63250424 |
Renal cyst | 14.78 | 9.85 | 77 | 237798 | 10225 | 63240922 |
Hypoparathyroidism secondary | 14.76 | 9.85 | 6 | 237869 | 46 | 63251101 |
Torsade de pointes | 14.70 | 9.85 | 93 | 237782 | 13258 | 63237889 |
Choroidal effusion | 14.61 | 9.85 | 13 | 237862 | 463 | 63250684 |
Neonatal respiratory distress | 14.60 | 9.85 | 12 | 237863 | 383 | 63250764 |
Confabulation | 14.58 | 9.85 | 11 | 237864 | 309 | 63250838 |
Renal injury | 14.56 | 9.85 | 72 | 237803 | 9367 | 63241780 |
Peripheral circulatory failure | 14.46 | 9.85 | 18 | 237857 | 950 | 63250197 |
Osmotic demyelination syndrome | 14.46 | 9.85 | 15 | 237860 | 648 | 63250499 |
Carpal tunnel syndrome | 14.42 | 9.85 | 130 | 237745 | 20687 | 63230460 |
Drug ineffective for unapproved indication | 14.42 | 9.85 | 72 | 237803 | 33991 | 63217156 |
Breast neoplasm | 14.41 | 9.85 | 22 | 237853 | 1410 | 63249737 |
Device difficult to use | 14.39 | 9.85 | 16 | 237859 | 12780 | 63238367 |
Angle closure glaucoma | 14.31 | 9.85 | 28 | 237847 | 2191 | 63248956 |
Subacute cutaneous lupus erythematosus | 14.28 | 9.85 | 31 | 237844 | 2612 | 63248535 |
Chest discomfort | 14.27 | 9.85 | 525 | 237350 | 109444 | 63141703 |
Myopathy | 14.27 | 9.85 | 81 | 237794 | 11110 | 63240037 |
Post-anoxic myoclonus | 14.25 | 9.85 | 5 | 237870 | 24 | 63251123 |
Lower limb fracture | 14.19 | 9.85 | 45 | 237830 | 24176 | 63226971 |
Multiple organ dysfunction syndrome | 14.14 | 9.85 | 140 | 237735 | 56612 | 63194535 |
International normalised ratio decreased | 14.11 | 9.85 | 43 | 237832 | 4458 | 63246689 |
Crystal arthropathy | 14.10 | 9.85 | 11 | 237864 | 325 | 63250822 |
Blood hyposmosis | 14.09 | 9.85 | 5 | 237870 | 25 | 63251122 |
Glomerulonephritis rapidly progressive | 14.07 | 9.85 | 18 | 237857 | 977 | 63250170 |
Gastroenteritis clostridial | 14.01 | 9.85 | 14 | 237861 | 578 | 63250569 |
Cardiac murmur | 13.99 | 9.85 | 98 | 237777 | 14454 | 63236693 |
Sleep disorder | 13.98 | 9.85 | 218 | 237657 | 81348 | 63169799 |
Dilatation atrial | 13.92 | 9.85 | 26 | 237849 | 1965 | 63249182 |
Haematotoxicity | 13.87 | 9.85 | 9 | 237866 | 9367 | 63241780 |
Temperature regulation disorder | 13.87 | 9.85 | 3 | 237872 | 6129 | 63245018 |
Vaginal flatulence | 13.83 | 9.85 | 35 | 237840 | 3258 | 63247889 |
Cardiac ventriculogram left | 13.77 | 9.85 | 3 | 237872 | 0 | 63251147 |
Cardiomegaly | 13.77 | 9.85 | 113 | 237762 | 17501 | 63233646 |
Renal artery dissection | 13.77 | 9.85 | 3 | 237872 | 0 | 63251147 |
Night sweats | 13.64 | 9.85 | 117 | 237758 | 48697 | 63202450 |
Abortion induced | 13.63 | 9.85 | 11 | 237864 | 10231 | 63240916 |
Respiratory disorder | 13.63 | 9.85 | 88 | 237787 | 38994 | 63212153 |
Cytopenia | 13.61 | 9.85 | 14 | 237861 | 11587 | 63239560 |
Liver disorder | 13.56 | 9.85 | 132 | 237743 | 53555 | 63197592 |
Stupor | 13.56 | 9.85 | 41 | 237834 | 4234 | 63246913 |
Gastrointestinal toxicity | 13.55 | 9.85 | 6 | 237869 | 7735 | 63243412 |
Pulpitis dental | 13.46 | 9.85 | 17 | 237858 | 911 | 63250236 |
Actinic keratosis | 13.46 | 9.85 | 30 | 237845 | 2574 | 63248573 |
Intervertebral disc degeneration | 13.44 | 9.85 | 103 | 237772 | 15629 | 63235518 |
Therapeutic response unexpected | 13.43 | 9.85 | 118 | 237757 | 18641 | 63232506 |
Product residue present | 13.41 | 9.85 | 39 | 237836 | 3940 | 63247207 |
Eosinophilia myalgia syndrome | 13.39 | 9.85 | 4 | 237871 | 10 | 63251137 |
Left ventricular hypertrophy | 13.28 | 9.85 | 47 | 237828 | 5268 | 63245879 |
Osteogenesis imperfecta | 13.23 | 9.85 | 14 | 237861 | 619 | 63250528 |
Vision blurred | 13.20 | 9.85 | 444 | 237431 | 91480 | 63159667 |
White blood cell count decreased | 13.07 | 9.85 | 409 | 237466 | 138695 | 63112452 |
Epileptic encephalopathy | 13.07 | 9.85 | 10 | 237865 | 287 | 63250860 |
Coronavirus test positive | 13.02 | 9.85 | 15 | 237860 | 730 | 63250417 |
Pollakiuria | 13.00 | 9.85 | 161 | 237714 | 27776 | 63223371 |
Orthostatic hypotension | 13 | 9.85 | 199 | 237676 | 35961 | 63215186 |
Ultrasound kidney abnormal | 12.94 | 9.85 | 5 | 237870 | 33 | 63251114 |
Gastritis | 12.92 | 9.85 | 204 | 237671 | 37099 | 63214048 |
Atrioventricular block second degree | 12.85 | 9.85 | 38 | 237837 | 3876 | 63247271 |
Accidental exposure to product | 12.73 | 9.85 | 56 | 237819 | 27349 | 63223798 |
Blood pressure abnormal | 12.70 | 9.85 | 99 | 237776 | 15099 | 63236048 |
Therapeutic product effect incomplete | 12.67 | 9.85 | 364 | 237511 | 124692 | 63126455 |
Lipohypertrophy | 12.66 | 9.85 | 14 | 237861 | 651 | 63250496 |
Product commingling | 12.59 | 9.85 | 8 | 237867 | 169 | 63250978 |
Endometrial hyperplasia | 12.57 | 9.85 | 16 | 237859 | 864 | 63250283 |
Chondropathy | 12.45 | 9.85 | 27 | 237848 | 2273 | 63248874 |
Osteomyelitis acute | 12.37 | 9.85 | 9 | 237866 | 239 | 63250908 |
Blood creatinine abnormal | 12.34 | 9.85 | 32 | 237843 | 3024 | 63248123 |
Laryngeal pain | 12.31 | 9.85 | 41 | 237834 | 4457 | 63246690 |
Vascular device infection | 12.29 | 9.85 | 6 | 237869 | 7306 | 63243841 |
Microalbuminuria | 12.28 | 9.85 | 11 | 237864 | 395 | 63250752 |
Endometrial cancer | 12.24 | 9.85 | 33 | 237842 | 3192 | 63247955 |
Allergic hepatitis | 12.23 | 9.85 | 5 | 237870 | 39 | 63251108 |
Chest wall mass | 12.21 | 9.85 | 6 | 237869 | 75 | 63251072 |
Hot flush | 12.20 | 9.85 | 264 | 237611 | 50895 | 63200252 |
Product administration error | 12.17 | 9.85 | 133 | 237742 | 22264 | 63228883 |
Disseminated intravascular coagulation | 12.17 | 9.85 | 34 | 237841 | 19017 | 63232130 |
Unintended pregnancy | 12.13 | 9.85 | 4 | 237871 | 6175 | 63244972 |
Non-cardiac chest pain | 12.02 | 9.85 | 51 | 237824 | 6221 | 63244926 |
Renal tubular necrosis | 12.02 | 9.85 | 81 | 237794 | 11797 | 63239350 |
Lip infection | 12.00 | 9.85 | 7 | 237868 | 126 | 63251021 |
Pituitary apoplexy | 12.00 | 9.85 | 7 | 237868 | 126 | 63251021 |
Glomerulonephritis | 11.91 | 9.85 | 23 | 237852 | 1783 | 63249364 |
Blood creatine increased | 11.88 | 9.85 | 47 | 237828 | 5554 | 63245593 |
Procedural complication | 11.83 | 9.85 | 46 | 237829 | 5393 | 63245754 |
Rheumatoid factor | 11.83 | 9.85 | 10 | 237865 | 332 | 63250815 |
Pharyngeal oedema | 11.81 | 9.85 | 90 | 237785 | 13631 | 63237516 |
Ageusia | 11.79 | 9.85 | 90 | 237785 | 13638 | 63237509 |
Anaemia postoperative | 11.78 | 9.85 | 26 | 237849 | 2216 | 63248931 |
Progressive multifocal leukoencephalopathy | 11.76 | 9.85 | 19 | 237856 | 12952 | 63238195 |
Renal impairment | 11.75 | 9.85 | 423 | 237452 | 87932 | 63163215 |
Gallbladder disorder | 11.72 | 9.85 | 115 | 237760 | 18727 | 63232420 |
Adrenocortical carcinoma | 11.71 | 9.85 | 5 | 237870 | 44 | 63251103 |
Gastric atony | 11.70 | 9.85 | 3 | 237872 | 3 | 63251144 |
Wound treatment | 11.69 | 9.85 | 8 | 237867 | 192 | 63250955 |
Lymphocyte count decreased | 11.67 | 9.85 | 66 | 237809 | 30191 | 63220956 |
Upper-airway cough syndrome | 11.63 | 9.85 | 78 | 237797 | 11340 | 63239807 |
Diabetic neuropathy | 11.63 | 9.85 | 37 | 237838 | 3927 | 63247220 |
Tanning | 11.61 | 9.85 | 6 | 237869 | 84 | 63251063 |
Respiratory depression | 11.60 | 9.85 | 21 | 237854 | 13694 | 63237453 |
Multiple drug therapy | 11.59 | 9.85 | 35 | 237840 | 3611 | 63247536 |
Gait disturbance | 11.58 | 9.85 | 816 | 237059 | 182362 | 63068785 |
Gastritis erosive | 11.49 | 9.85 | 49 | 237826 | 5990 | 63245157 |
Cutaneous T-cell lymphoma stage I | 11.44 | 9.85 | 4 | 237871 | 19 | 63251128 |
Skin pressure mark | 11.44 | 9.85 | 4 | 237871 | 19 | 63251128 |
Chronic kidney disease | 11.39 | 9.85 | 236 | 237639 | 45162 | 63205985 |
Myelodysplastic syndrome | 11.38 | 9.85 | 29 | 237846 | 16725 | 63234422 |
Tremor | 11.33 | 9.85 | 605 | 237270 | 131634 | 63119513 |
Memory impairment | 11.26 | 9.85 | 488 | 237387 | 103770 | 63147377 |
Vasculitis | 11.26 | 9.85 | 111 | 237764 | 18098 | 63233049 |
Nodal rhythm | 11.25 | 9.85 | 22 | 237853 | 1721 | 63249426 |
Encephalitis | 11.25 | 9.85 | 10 | 237865 | 8870 | 63242277 |
Abdominal panniculectomy | 11.25 | 9.85 | 3 | 237872 | 4 | 63251143 |
Diverticulum oesophageal | 11.17 | 9.85 | 7 | 237868 | 144 | 63251003 |
Lung disorder | 11.15 | 9.85 | 165 | 237710 | 62096 | 63189051 |
Foreign body in reproductive tract | 11.13 | 9.85 | 14 | 237861 | 747 | 63250400 |
Hyponatraemic syndrome | 11.11 | 9.85 | 12 | 237863 | 543 | 63250604 |
Delayed fontanelle closure | 11.11 | 9.85 | 4 | 237871 | 21 | 63251126 |
Device dislocation | 11.07 | 9.85 | 54 | 237821 | 25651 | 63225496 |
Macrocytosis | 11.06 | 9.85 | 27 | 237848 | 2458 | 63248689 |
Maternal drugs affecting foetus | 11.00 | 9.85 | 3 | 237872 | 5239 | 63245908 |
Oesophageal oedema | 10.98 | 9.85 | 5 | 237870 | 52 | 63251095 |
Hyperammonaemia | 10.97 | 9.85 | 3 | 237872 | 5229 | 63245918 |
Lipoedema | 10.90 | 9.85 | 9 | 237866 | 289 | 63250858 |
Dermatitis atopic | 10.87 | 9.85 | 68 | 237807 | 9656 | 63241491 |
Oral fibroma | 10.82 | 9.85 | 5 | 237870 | 54 | 63251093 |
Vitiligo | 10.81 | 9.85 | 19 | 237856 | 1370 | 63249777 |
Chills | 10.80 | 9.85 | 524 | 237351 | 112854 | 63138293 |
Muscle twitching | 10.78 | 9.85 | 117 | 237758 | 19551 | 63231596 |
Multiple-drug resistance | 10.78 | 9.85 | 3 | 237872 | 5167 | 63245980 |
Neuroglycopenia | 10.76 | 9.85 | 11 | 237864 | 467 | 63250680 |
Sleep apnoea syndrome | 10.73 | 9.85 | 161 | 237714 | 28972 | 63222175 |
Vomiting | 10.69 | 9.85 | 2311 | 235564 | 557306 | 62693841 |
Cardiac output increased | 10.69 | 9.85 | 8 | 237867 | 222 | 63250925 |
Aphthous ulcer | 10.67 | 9.85 | 89 | 237786 | 13849 | 63237298 |
Clostridium difficile infection | 10.62 | 9.85 | 67 | 237808 | 29855 | 63221292 |
Retroperitoneal fibrosis | 10.62 | 9.85 | 9 | 237866 | 300 | 63250847 |
Hypertrichosis | 10.60 | 9.85 | 17 | 237858 | 1137 | 63250010 |
Vascular access site pain | 10.58 | 9.85 | 6 | 237869 | 102 | 63251045 |
Non-Hodgkin's lymphoma | 10.58 | 9.85 | 19 | 237856 | 1393 | 63249754 |
Adiposis dolorosa | 10.51 | 9.85 | 9 | 237866 | 304 | 63250843 |
Femoral bruit | 10.50 | 9.85 | 3 | 237872 | 6 | 63251141 |
Iliac artery embolism | 10.50 | 9.85 | 3 | 237872 | 6 | 63251141 |
Eczema weeping | 10.50 | 9.85 | 3 | 237872 | 6 | 63251141 |
Haemorrhagic fever | 10.50 | 9.85 | 3 | 237872 | 6 | 63251141 |
Encephalomalacia | 10.47 | 9.85 | 11 | 237864 | 482 | 63250665 |
Thyroid neoplasm | 10.44 | 9.85 | 36 | 237839 | 3983 | 63247164 |
Nocturia | 10.43 | 9.85 | 59 | 237816 | 8082 | 63243065 |
Fibrosis | 10.41 | 9.85 | 37 | 237838 | 4155 | 63246992 |
Paraesthesia | 10.41 | 9.85 | 702 | 237173 | 156264 | 63094883 |
Blood potassium abnormal | 10.33 | 9.85 | 27 | 237848 | 2563 | 63248584 |
Exposure to toxic agent | 10.31 | 9.85 | 4 | 237871 | 5583 | 63245564 |
Prothrombin time abnormal | 10.29 | 9.85 | 11 | 237864 | 492 | 63250655 |
Arteriosclerosis coronary artery | 10.28 | 9.85 | 60 | 237815 | 8313 | 63242834 |
Antidiuretic hormone abnormality | 10.27 | 9.85 | 4 | 237871 | 27 | 63251120 |
Dementia Alzheimer's type | 10.27 | 9.85 | 16 | 237859 | 1044 | 63250103 |
Pruritus allergic | 10.25 | 9.85 | 20 | 237855 | 1562 | 63249585 |
Immune reconstitution inflammatory syndrome | 10.21 | 9.85 | 5 | 237870 | 6079 | 63245068 |
Vulvovaginal pruritus | 10.19 | 9.85 | 31 | 237844 | 3212 | 63247935 |
Mouth ulceration | 10.16 | 9.85 | 77 | 237798 | 32907 | 63218240 |
Cerebral ischaemia | 10.15 | 9.85 | 51 | 237824 | 6677 | 63244470 |
Agranulocytosis | 10.14 | 9.85 | 54 | 237821 | 25080 | 63226067 |
Vertebral artery stenosis | 10.14 | 9.85 | 5 | 237870 | 63 | 63251084 |
Overweight | 10.09 | 9.85 | 34 | 237841 | 3717 | 63247430 |
Endophthalmitis | 10.06 | 9.85 | 33 | 237842 | 3559 | 63247588 |
Poor personal hygiene | 10.06 | 9.85 | 9 | 237866 | 323 | 63250824 |
Thrombotic microangiopathy | 10.02 | 9.85 | 15 | 237860 | 10546 | 63240601 |
Varicose vein ruptured | 10.00 | 9.85 | 5 | 237870 | 65 | 63251082 |
Blood pressure systolic abnormal | 10.00 | 9.85 | 85 | 237790 | 13301 | 63237846 |
Coma acidotic | 10.00 | 9.85 | 6 | 237869 | 114 | 63251033 |
Tricuspid valve incompetence | 9.97 | 9.85 | 91 | 237784 | 14530 | 63236617 |
Allergic cough | 9.94 | 9.85 | 13 | 237862 | 721 | 63250426 |
Endometrial disorder | 9.87 | 9.85 | 13 | 237862 | 726 | 63250421 |
Normal newborn | 9.86 | 9.85 | 10 | 237865 | 8331 | 63242816 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hyponatraemia | 458.54 | 10.35 | 974 | 128948 | 81717 | 34745292 |
Angioedema | 394.36 | 10.35 | 584 | 129338 | 36790 | 34790219 |
Off label use | 295.07 | 10.35 | 708 | 129214 | 418816 | 34408193 |
Hypokalaemia | 251.83 | 10.35 | 622 | 129300 | 57592 | 34769417 |
Drug abuse | 216.86 | 10.35 | 51 | 129871 | 99045 | 34727964 |
Acute kidney injury | 216.68 | 10.35 | 1899 | 128023 | 303089 | 34523920 |
Dizziness | 165.00 | 10.35 | 1380 | 128542 | 217141 | 34609868 |
Syncope | 155.66 | 10.35 | 713 | 129209 | 90738 | 34736271 |
Cerebrovascular accident | 150.90 | 10.35 | 670 | 129252 | 84141 | 34742868 |
Death | 150.57 | 10.35 | 867 | 129055 | 397182 | 34429827 |
Coronary artery disease | 121.00 | 10.35 | 425 | 129497 | 47880 | 34779129 |
Blood glucose increased | 117.82 | 10.35 | 526 | 129396 | 66192 | 34760817 |
Product use in unapproved indication | 114.34 | 10.35 | 162 | 129760 | 117337 | 34709672 |
Myocardial infarction | 114.23 | 10.35 | 806 | 129116 | 120279 | 34706730 |
Neutropenia | 112.47 | 10.35 | 261 | 129661 | 156517 | 34670492 |
Febrile neutropenia | 109.69 | 10.35 | 214 | 129708 | 136635 | 34690374 |
Pneumonia | 103.22 | 10.35 | 858 | 129064 | 361769 | 34465240 |
Pyrexia | 103.09 | 10.35 | 770 | 129152 | 332243 | 34494766 |
Cardiospasm | 99.26 | 10.35 | 66 | 129856 | 1522 | 34825487 |
Drug ineffective | 97.38 | 10.35 | 1159 | 128763 | 455592 | 34371417 |
Hypotension | 96.15 | 10.35 | 1251 | 128671 | 220398 | 34606611 |
Blood pressure inadequately controlled | 95.61 | 10.35 | 79 | 129843 | 2561 | 34824448 |
Dehydration | 95.31 | 10.35 | 816 | 129106 | 129153 | 34697856 |
Blood pressure increased | 94.78 | 10.35 | 606 | 129316 | 87496 | 34739513 |
Carotid artery occlusion | 90.23 | 10.35 | 89 | 129833 | 3648 | 34823361 |
Milk-alkali syndrome | 89.11 | 10.35 | 44 | 129878 | 561 | 34826448 |
Palmoplantar keratoderma | 86.97 | 10.35 | 66 | 129856 | 1887 | 34825122 |
Sepsis | 84.32 | 10.35 | 326 | 129596 | 166235 | 34660774 |
Facial pain | 83.52 | 10.35 | 85 | 129837 | 3619 | 34823390 |
Pancreatitis acute | 81.45 | 10.35 | 260 | 129662 | 27881 | 34799128 |
Toxicity to various agents | 81.14 | 10.35 | 426 | 129496 | 199936 | 34627073 |
Pruritus genital | 77.84 | 10.35 | 65 | 129857 | 2139 | 34824870 |
Sleep terror | 74.98 | 10.35 | 65 | 129857 | 2253 | 34824756 |
Thrombocytopenia | 71.48 | 10.35 | 318 | 129604 | 155929 | 34671080 |
Atrial tachycardia | 70.36 | 10.35 | 77 | 129845 | 3568 | 34823441 |
Immunisation | 70.33 | 10.35 | 46 | 129876 | 1031 | 34825978 |
Blood potassium decreased | 69.67 | 10.35 | 184 | 129738 | 17731 | 34809278 |
Tension headache | 67.12 | 10.35 | 69 | 129853 | 2973 | 34824036 |
Transient ischaemic attack | 64.90 | 10.35 | 238 | 129684 | 27375 | 34799634 |
Anosmia | 62.52 | 10.35 | 76 | 129846 | 3948 | 34823061 |
Cytomegalovirus infection | 58.02 | 10.35 | 13 | 129909 | 26122 | 34800887 |
Treatment failure | 56.57 | 10.35 | 54 | 129868 | 46643 | 34780366 |
Product use issue | 54.92 | 10.35 | 94 | 129828 | 63122 | 34763887 |
Pancreatitis | 53.11 | 10.35 | 285 | 129637 | 38606 | 34788403 |
Hypertensive crisis | 50.60 | 10.35 | 105 | 129817 | 8646 | 34818363 |
IgM nephropathy | 50.15 | 10.35 | 19 | 129903 | 119 | 34826890 |
Foetal exposure during pregnancy | 49.83 | 10.35 | 41 | 129881 | 38060 | 34788949 |
Cytokine release syndrome | 49.55 | 10.35 | 12 | 129910 | 22865 | 34804144 |
Hepatic function abnormal | 49.54 | 10.35 | 55 | 129867 | 44308 | 34782701 |
Bundle branch block left | 47.30 | 10.35 | 82 | 129840 | 5897 | 34821112 |
Eye pruritus | 47.04 | 10.35 | 93 | 129829 | 7396 | 34819613 |
Hypovolaemia | 46.76 | 10.35 | 105 | 129817 | 9129 | 34817880 |
Interstitial lung disease | 45.68 | 10.35 | 110 | 129812 | 65172 | 34761837 |
Leukopenia | 44.71 | 10.35 | 105 | 129817 | 62751 | 34764258 |
Hospitalisation | 44.65 | 10.35 | 90 | 129832 | 56812 | 34770197 |
Blood mercury abnormal | 43.58 | 10.35 | 20 | 129902 | 214 | 34826795 |
Pain of skin | 43.47 | 10.35 | 80 | 129842 | 6029 | 34820980 |
5-hydroxyindolacetic acid in urine increased | 41.79 | 10.35 | 20 | 129902 | 237 | 34826772 |
Orthostatic intolerance | 41.56 | 10.35 | 30 | 129892 | 793 | 34826216 |
Sprue-like enteropathy | 41.25 | 10.35 | 25 | 129897 | 488 | 34826521 |
Myelosuppression | 40.01 | 10.35 | 11 | 129911 | 19254 | 34807755 |
Drug intolerance | 39.63 | 10.35 | 103 | 129819 | 59467 | 34767542 |
Cardiac failure congestive | 38.52 | 10.35 | 476 | 129446 | 82794 | 34744215 |
Lactic acidosis | 38.47 | 10.35 | 241 | 129681 | 34531 | 34792478 |
Blood creatinine increased | 38.12 | 10.35 | 529 | 129393 | 94447 | 34732562 |
Injury | 37.15 | 10.35 | 164 | 129758 | 20523 | 34806486 |
Cardiomegaly | 37.06 | 10.35 | 134 | 129788 | 15304 | 34811705 |
Carotid artery stenosis | 36.06 | 10.35 | 66 | 129856 | 4953 | 34822056 |
Hypochloraemia | 36.01 | 10.35 | 25 | 129897 | 620 | 34826389 |
Interstitial granulomatous dermatitis | 35.29 | 10.35 | 16 | 129906 | 166 | 34826843 |
Blood urea increased | 35.19 | 10.35 | 213 | 129709 | 30151 | 34796858 |
Drug resistance | 35.03 | 10.35 | 27 | 129895 | 25900 | 34801109 |
Tinnitus | 35.01 | 10.35 | 158 | 129764 | 19960 | 34807049 |
Metabolic alkalosis | 34.86 | 10.35 | 35 | 129887 | 1466 | 34825543 |
Lip swelling | 34.79 | 10.35 | 135 | 129787 | 15945 | 34811064 |
Amnesia | 34.47 | 10.35 | 192 | 129730 | 26371 | 34800638 |
Renal artery stenosis | 33.99 | 10.35 | 42 | 129880 | 2219 | 34824790 |
Blood chloride decreased | 33.76 | 10.35 | 55 | 129867 | 3758 | 34823251 |
Muscle twitching | 33.37 | 10.35 | 99 | 129823 | 10199 | 34816810 |
Bronchopulmonary aspergillosis | 33.13 | 10.35 | 7 | 129915 | 14652 | 34812357 |
Chest pain | 32.75 | 10.35 | 657 | 129265 | 126105 | 34700904 |
Pancytopenia | 32.74 | 10.35 | 213 | 129709 | 94944 | 34732065 |
Acute myocardial infarction | 32.10 | 10.35 | 323 | 129599 | 53396 | 34773613 |
Inappropriate antidiuretic hormone secretion | 31.73 | 10.35 | 112 | 129810 | 12641 | 34814368 |
Diplopia | 31.37 | 10.35 | 135 | 129787 | 16708 | 34810301 |
Hypomagnesaemia | 31.10 | 10.35 | 162 | 129760 | 21689 | 34805320 |
Pulmonary valve disease | 30.93 | 10.35 | 18 | 129904 | 325 | 34826684 |
Drug-induced liver injury | 30.83 | 10.35 | 37 | 129885 | 28795 | 34798214 |
Bone marrow failure | 30.80 | 10.35 | 38 | 129884 | 29215 | 34797794 |
Liver disorder | 30.58 | 10.35 | 47 | 129875 | 32950 | 34794059 |
Vasculitis | 30.54 | 10.35 | 102 | 129820 | 11194 | 34815815 |
Neutrophil count decreased | 29.85 | 10.35 | 94 | 129828 | 51010 | 34775999 |
Arteriosclerosis coronary artery | 29.65 | 10.35 | 108 | 129814 | 12377 | 34814632 |
Glycosylated haemoglobin increased | 29.33 | 10.35 | 101 | 129821 | 11259 | 34815750 |
Pneumonia aspiration | 29.00 | 10.35 | 71 | 129851 | 41832 | 34785177 |
Renal failure | 29.00 | 10.35 | 662 | 129260 | 129895 | 34697114 |
Pericardial disease | 28.85 | 10.35 | 19 | 129903 | 431 | 34826578 |
Infection | 28.56 | 10.35 | 209 | 129713 | 90706 | 34736303 |
Granulomatous pneumonitis | 28.53 | 10.35 | 9 | 129913 | 29 | 34826980 |
Hypertension | 28.21 | 10.35 | 685 | 129237 | 135758 | 34691251 |
Hypercalcaemia | 28.06 | 10.35 | 123 | 129799 | 15345 | 34811664 |
Platelet count decreased | 27.98 | 10.35 | 297 | 129625 | 119420 | 34707589 |
Aspergillus infection | 27.39 | 10.35 | 6 | 129916 | 12248 | 34814761 |
Erectile dysfunction | 27.33 | 10.35 | 150 | 129772 | 20487 | 34806522 |
Bacteraemia | 27.32 | 10.35 | 20 | 129902 | 19697 | 34807312 |
Blood pressure systolic increased | 27.23 | 10.35 | 162 | 129760 | 22790 | 34804219 |
Low density lipoprotein decreased | 27.18 | 10.35 | 27 | 129895 | 1116 | 34825893 |
Sopor | 27.01 | 10.35 | 6 | 129916 | 12130 | 34814879 |
Neurotoxicity | 26.65 | 10.35 | 17 | 129905 | 17993 | 34809016 |
Lower respiratory tract infection | 26.60 | 10.35 | 48 | 129874 | 31589 | 34795420 |
Intentional self-injury | 26.55 | 10.35 | 9 | 129913 | 13762 | 34813247 |
Blood sodium decreased | 26.33 | 10.35 | 125 | 129797 | 16126 | 34810883 |
Visual impairment | 26.28 | 10.35 | 225 | 129697 | 35577 | 34791432 |
Angina pectoris | 25.66 | 10.35 | 202 | 129720 | 31161 | 34795848 |
Blindness | 25.55 | 10.35 | 117 | 129805 | 14869 | 34812140 |
Fall | 25.55 | 10.35 | 958 | 128964 | 201927 | 34625082 |
Hypertensive emergency | 25.54 | 10.35 | 25 | 129897 | 1015 | 34825994 |
Nodular rash | 25.53 | 10.35 | 11 | 129911 | 100 | 34826909 |
Actinic keratosis | 25.47 | 10.35 | 54 | 129868 | 4513 | 34822496 |
Choroidal effusion | 25.38 | 10.35 | 13 | 129909 | 180 | 34826829 |
Rash papular | 25.34 | 10.35 | 90 | 129832 | 10188 | 34816821 |
Vertigo | 25.20 | 10.35 | 172 | 129750 | 25364 | 34801645 |
Mitral valve incompetence | 24.99 | 10.35 | 116 | 129806 | 14827 | 34812182 |
Ventricular tachycardia | 24.46 | 10.35 | 176 | 129746 | 26403 | 34800606 |
Disseminated intravascular coagulation | 24.40 | 10.35 | 27 | 129895 | 21789 | 34805220 |
Oedema peripheral | 24.00 | 10.35 | 599 | 129323 | 119213 | 34707796 |
Peritonitis | 23.46 | 10.35 | 16 | 129906 | 16349 | 34810660 |
Hyperhidrosis | 23.23 | 10.35 | 403 | 129519 | 75289 | 34751720 |
Blood triglycerides increased | 23.01 | 10.35 | 109 | 129813 | 14050 | 34812959 |
C-reactive protein increased | 22.98 | 10.35 | 113 | 129809 | 53985 | 34773024 |
Drug dependence | 22.92 | 10.35 | 34 | 129888 | 24183 | 34802826 |
Choroidal detachment | 22.73 | 10.35 | 16 | 129906 | 406 | 34826603 |
Lichen planus | 22.66 | 10.35 | 23 | 129899 | 976 | 34826033 |
Mucosal inflammation | 22.58 | 10.35 | 71 | 129851 | 38551 | 34788458 |
Hepatic neoplasm | 22.43 | 10.35 | 32 | 129890 | 1945 | 34825064 |
Muscular weakness | 22.33 | 10.35 | 388 | 129534 | 72509 | 34754500 |
Bradycardia | 22.24 | 10.35 | 399 | 129523 | 75019 | 34751990 |
Angina unstable | 22.16 | 10.35 | 94 | 129828 | 11559 | 34815450 |
Lymphocyte count decreased | 22.16 | 10.35 | 31 | 129891 | 22591 | 34804418 |
Graft versus host disease | 22.01 | 10.35 | 6 | 129916 | 10563 | 34816446 |
Malignant neoplasm progression | 21.98 | 10.35 | 215 | 129707 | 87831 | 34739178 |
Renal injury | 21.83 | 10.35 | 91 | 129831 | 11104 | 34815905 |
Multiple organ dysfunction syndrome | 21.71 | 10.35 | 181 | 129741 | 76385 | 34750624 |
Physical examination abnormal | 21.71 | 10.35 | 14 | 129908 | 306 | 34826703 |
Septic shock | 21.67 | 10.35 | 167 | 129755 | 71667 | 34755342 |
Polydipsia | 21.50 | 10.35 | 46 | 129876 | 3869 | 34823140 |
High density lipoprotein decreased | 21.43 | 10.35 | 42 | 129880 | 3318 | 34823691 |
Disease progression | 21.43 | 10.35 | 278 | 129644 | 107799 | 34719210 |
Pneumocystis jirovecii pneumonia | 21.39 | 10.35 | 25 | 129897 | 19685 | 34807324 |
Swollen tongue | 21.28 | 10.35 | 109 | 129813 | 14496 | 34812513 |
Aplastic anaemia | 21.23 | 10.35 | 5 | 129917 | 9711 | 34817298 |
Tricuspid valve incompetence | 21.16 | 10.35 | 82 | 129840 | 9678 | 34817331 |
Vestibular neuronitis | 21.16 | 10.35 | 12 | 129910 | 206 | 34826803 |
Inappropriate schedule of product administration | 21.13 | 10.35 | 140 | 129782 | 62156 | 34764853 |
Ascites | 21.12 | 10.35 | 95 | 129827 | 46476 | 34780533 |
Congenital diaphragmatic anomaly | 21.03 | 10.35 | 7 | 129915 | 28 | 34826981 |
Osteoarthritis | 20.94 | 10.35 | 140 | 129782 | 20502 | 34806507 |
Hyperlipidaemia | 20.87 | 10.35 | 108 | 129814 | 14421 | 34812588 |
Arrhythmia | 20.76 | 10.35 | 214 | 129708 | 35594 | 34791415 |
Therapeutic product effect incomplete | 20.65 | 10.35 | 107 | 129815 | 50434 | 34776575 |
Sedation | 20.36 | 10.35 | 29 | 129893 | 20977 | 34806032 |
Akathisia | 20.22 | 10.35 | 3 | 129919 | 8106 | 34818903 |
Immune reconstitution inflammatory syndrome | 20.17 | 10.35 | 4 | 129918 | 8755 | 34818254 |
Heart rate increased | 20.17 | 10.35 | 262 | 129660 | 46081 | 34780928 |
Blood cholesterol increased | 20.05 | 10.35 | 138 | 129784 | 20405 | 34806604 |
Pseudolymphoma | 20.05 | 10.35 | 18 | 129904 | 654 | 34826355 |
Palpitations | 19.97 | 10.35 | 232 | 129690 | 39754 | 34787255 |
Pulmonary valve stenosis congenital | 19.95 | 10.35 | 10 | 129912 | 132 | 34826877 |
Drug ineffective for unapproved indication | 19.92 | 10.35 | 36 | 129886 | 23679 | 34803330 |
Blood pressure decreased | 19.87 | 10.35 | 285 | 129637 | 51230 | 34775779 |
Migraine | 19.86 | 10.35 | 122 | 129800 | 17356 | 34809653 |
Stomatitis | 19.72 | 10.35 | 86 | 129836 | 42428 | 34784581 |
Ventricular hypertrophy | 19.65 | 10.35 | 49 | 129873 | 4558 | 34822451 |
Colitis | 19.63 | 10.35 | 73 | 129849 | 37677 | 34789332 |
Subarachnoid haemorrhage | 19.62 | 10.35 | 96 | 129826 | 12539 | 34814470 |
Acquired acrodermatitis enteropathica | 19.55 | 10.35 | 5 | 129917 | 5 | 34827004 |
Contraindicated product administered | 19.52 | 10.35 | 31 | 129891 | 21450 | 34805559 |
Microalbuminuria | 19.38 | 10.35 | 18 | 129904 | 684 | 34826325 |
Gout | 19.19 | 10.35 | 130 | 129792 | 19123 | 34807886 |
Intestinal villi atrophy | 19.18 | 10.35 | 10 | 129912 | 144 | 34826865 |
Condition aggravated | 19.10 | 10.35 | 556 | 129366 | 191640 | 34635369 |
Lymphomatoid papulosis | 19.08 | 10.35 | 11 | 129911 | 195 | 34826814 |
Alkalosis hypochloraemic | 18.85 | 10.35 | 13 | 129909 | 319 | 34826690 |
Shock | 18.83 | 10.35 | 154 | 129768 | 24025 | 34802984 |
Extrasystoles | 18.83 | 10.35 | 43 | 129879 | 3780 | 34823229 |
Dry skin | 18.62 | 10.35 | 188 | 129734 | 31099 | 34795910 |
Electrolyte imbalance | 18.58 | 10.35 | 104 | 129818 | 14308 | 34812701 |
Synovitis | 18.56 | 10.35 | 15 | 129907 | 14051 | 34812958 |
Pharyngeal oedema | 18.53 | 10.35 | 57 | 129865 | 5990 | 34821019 |
Product complaint | 18.50 | 10.35 | 56 | 129866 | 5834 | 34821175 |
Pericarditis | 18.45 | 10.35 | 89 | 129833 | 11556 | 34815453 |
Aortic valve incompetence | 18.41 | 10.35 | 56 | 129866 | 5848 | 34821161 |
CD4/CD8 ratio increased | 18.40 | 10.35 | 4 | 129918 | 0 | 34827009 |
Renin decreased | 18.40 | 10.35 | 4 | 129918 | 0 | 34827009 |
Drug reaction with eosinophilia and systemic symptoms | 18.39 | 10.35 | 62 | 129860 | 32950 | 34794059 |
Fatigue | 18.33 | 10.35 | 1607 | 128315 | 369046 | 34457963 |
Pancreatitis necrotising | 18.23 | 10.35 | 35 | 129887 | 2723 | 34824286 |
Hypophagia | 18.17 | 10.35 | 152 | 129770 | 23870 | 34803139 |
Transaminases increased | 18.12 | 10.35 | 46 | 129876 | 26777 | 34800232 |
Toxic epidermal necrolysis | 18.05 | 10.35 | 33 | 129889 | 21613 | 34805396 |
Seizure | 17.86 | 10.35 | 278 | 129644 | 104579 | 34722430 |
Dystonia | 17.82 | 10.35 | 9 | 129913 | 10836 | 34816173 |
Mastitis | 17.77 | 10.35 | 10 | 129912 | 169 | 34826840 |
Hyperkalaemia | 17.68 | 10.35 | 359 | 129563 | 69030 | 34757979 |
Therapy non-responder | 17.66 | 10.35 | 80 | 129842 | 39066 | 34787943 |
Mitral valve disease | 17.64 | 10.35 | 24 | 129898 | 1395 | 34825614 |
Muscle necrosis | 17.59 | 10.35 | 19 | 129903 | 867 | 34826142 |
Psoriasis | 17.56 | 10.35 | 221 | 129701 | 38591 | 34788418 |
Renal artery stent placement | 17.54 | 10.35 | 5 | 129917 | 10 | 34826999 |
Renal artery angioplasty | 17.54 | 10.35 | 5 | 129917 | 10 | 34826999 |
Spinal cord infarction | 17.52 | 10.35 | 12 | 129910 | 291 | 34826718 |
Cytopenia | 17.51 | 10.35 | 13 | 129909 | 12710 | 34814299 |
Electrocardiogram Q wave abnormal | 17.45 | 10.35 | 14 | 129908 | 435 | 34826574 |
Precancerous skin lesion | 17.44 | 10.35 | 16 | 129906 | 598 | 34826411 |
Hemiparesis | 17.22 | 10.35 | 109 | 129813 | 15669 | 34811340 |
Premature baby | 17.22 | 10.35 | 29 | 129893 | 19604 | 34807405 |
Infusion related reaction | 17.12 | 10.35 | 121 | 129801 | 52936 | 34774073 |
Miosis | 17.09 | 10.35 | 7 | 129915 | 9528 | 34817481 |
Myocardial ischaemia | 17.02 | 10.35 | 117 | 129805 | 17291 | 34809718 |
Sinus bradycardia | 17.01 | 10.35 | 94 | 129828 | 12869 | 34814140 |
Expired product administered | 16.92 | 10.35 | 38 | 129884 | 3303 | 34823706 |
Renal tubular necrosis | 16.91 | 10.35 | 108 | 129814 | 15572 | 34811437 |
Haemophagocytic lymphohistiocytosis | 16.91 | 10.35 | 14 | 129908 | 12959 | 34814050 |
Low density lipoprotein increased | 16.67 | 10.35 | 45 | 129877 | 4391 | 34822618 |
Coronary arterial stent insertion | 16.65 | 10.35 | 43 | 129879 | 4086 | 34822923 |
Laryngeal cleft | 16.64 | 10.35 | 5 | 129917 | 13 | 34826996 |
Left ventricular hypertrophy | 16.57 | 10.35 | 67 | 129855 | 8063 | 34818946 |
Carcinoid tumour of the gastrointestinal tract | 16.50 | 10.35 | 7 | 129915 | 61 | 34826948 |
Gastrointestinal tract mucosal pigmentation | 16.38 | 10.35 | 14 | 129908 | 476 | 34826533 |
Hormone level abnormal | 16.37 | 10.35 | 13 | 129909 | 398 | 34826611 |
Transplant rejection | 16.29 | 10.35 | 9 | 129913 | 10302 | 34816707 |
Neoplasm | 16.26 | 10.35 | 51 | 129871 | 5416 | 34821593 |
Polyuria | 16.18 | 10.35 | 69 | 129853 | 8505 | 34818504 |
Occult blood | 16.17 | 10.35 | 18 | 129904 | 850 | 34826159 |
Lymphangiectasia intestinal | 16.17 | 10.35 | 4 | 129918 | 3 | 34827006 |
Coronary artery occlusion | 16.11 | 10.35 | 82 | 129840 | 10880 | 34816129 |
Kidney transplant rejection | 16.10 | 10.35 | 4 | 129918 | 7493 | 34819516 |
Tumour lysis syndrome | 16.09 | 10.35 | 24 | 129898 | 17035 | 34809974 |
Alanine aminotransferase increased | 15.96 | 10.35 | 208 | 129714 | 80607 | 34746402 |
Ventricular arrhythmia | 15.92 | 10.35 | 51 | 129871 | 5477 | 34821532 |
Enterocolitis | 15.90 | 10.35 | 5 | 129917 | 8021 | 34818988 |
Anhedonia | 15.86 | 10.35 | 63 | 129859 | 7522 | 34819487 |
Paresis cranial nerve | 15.67 | 10.35 | 7 | 129915 | 70 | 34826939 |
Atrial fibrillation | 15.63 | 10.35 | 579 | 129343 | 121814 | 34705195 |
White blood cell count decreased | 15.60 | 10.35 | 255 | 129667 | 95190 | 34731819 |
Gastrointestinal angiodysplasia | 15.55 | 10.35 | 15 | 129907 | 598 | 34826411 |
Neutropenic sepsis | 15.44 | 10.35 | 17 | 129905 | 13750 | 34813259 |
Fluid intake reduced | 15.40 | 10.35 | 39 | 129883 | 3662 | 34823347 |
Exposure during pregnancy | 15.31 | 10.35 | 7 | 129915 | 8927 | 34818082 |
Shoshin beriberi | 15.24 | 10.35 | 7 | 129915 | 75 | 34826934 |
Dysgeusia | 15.19 | 10.35 | 158 | 129764 | 26339 | 34800670 |
Eosinophilic colitis | 15.18 | 10.35 | 10 | 129912 | 227 | 34826782 |
Product monitoring error | 15.04 | 10.35 | 43 | 129879 | 4338 | 34822671 |
Pleural effusion | 14.98 | 10.35 | 213 | 129709 | 81333 | 34745676 |
Myalgia | 14.95 | 10.35 | 414 | 129508 | 83696 | 34743313 |
Acute cutaneous lupus erythematosus | 14.93 | 10.35 | 7 | 129915 | 79 | 34826930 |
Dilatation atrial | 14.92 | 10.35 | 27 | 129895 | 2008 | 34825001 |
Diastolic dysfunction | 14.90 | 10.35 | 54 | 129868 | 6173 | 34820836 |
Incorrect route of product administration | 14.88 | 10.35 | 20 | 129902 | 14825 | 34812184 |
Vascular purpura | 14.87 | 10.35 | 25 | 129897 | 1753 | 34825256 |
Supraventricular tachycardia | 14.85 | 10.35 | 81 | 129841 | 11036 | 34815973 |
Febrile bone marrow aplasia | 14.75 | 10.35 | 6 | 129916 | 8203 | 34818806 |
Substance abuse | 14.72 | 10.35 | 5 | 129917 | 7636 | 34819373 |
Hemiataxia | 14.70 | 10.35 | 6 | 129916 | 47 | 34826962 |
Type 2 diabetes mellitus | 14.65 | 10.35 | 106 | 129816 | 15926 | 34811083 |
Supraventricular extrasystoles | 14.63 | 10.35 | 37 | 129885 | 3471 | 34823538 |
Orthostatic hypotension | 14.60 | 10.35 | 154 | 129768 | 25765 | 34801244 |
Aggression | 14.54 | 10.35 | 85 | 129837 | 38879 | 34788130 |
Arteriosclerosis | 14.53 | 10.35 | 85 | 129837 | 11883 | 34815126 |
Intentional product use issue | 14.53 | 10.35 | 147 | 129775 | 59669 | 34767340 |
Aortic arteriosclerosis | 14.48 | 10.35 | 44 | 129878 | 4592 | 34822417 |
Electrocardiogram U-wave abnormality | 14.48 | 10.35 | 6 | 129916 | 49 | 34826960 |
Fear | 14.45 | 10.35 | 77 | 129845 | 10399 | 34816610 |
Epilepsy | 14.42 | 10.35 | 37 | 129885 | 21458 | 34805551 |
Agitation | 14.38 | 10.35 | 140 | 129782 | 57259 | 34769750 |
Therapy partial responder | 14.33 | 10.35 | 9 | 129913 | 9607 | 34817402 |
Pathogen resistance | 13.96 | 10.35 | 9 | 129913 | 9473 | 34817536 |
Infective pulmonary exacerbation of cystic fibrosis | 13.90 | 10.35 | 4 | 129918 | 6797 | 34820212 |
Waist circumference increased | 13.89 | 10.35 | 17 | 129905 | 889 | 34826120 |
Atrioventricular block first degree | 13.88 | 10.35 | 52 | 129870 | 6040 | 34820969 |
Shock hypoglycaemic | 13.79 | 10.35 | 7 | 129915 | 95 | 34826914 |
Tendon rupture | 13.67 | 10.35 | 57 | 129865 | 6955 | 34820054 |
Cardiac discomfort | 13.64 | 10.35 | 14 | 129908 | 602 | 34826407 |
Patent ductus arteriosus | 13.60 | 10.35 | 35 | 129887 | 3319 | 34823690 |
Renin increased | 13.60 | 10.35 | 7 | 129915 | 98 | 34826911 |
Preternatural anus | 13.60 | 10.35 | 7 | 129915 | 98 | 34826911 |
Torsade de pointes | 13.59 | 10.35 | 58 | 129864 | 7151 | 34819858 |
Carcinogenicity | 13.52 | 10.35 | 6 | 129916 | 59 | 34826950 |
Brain stem infarction | 13.46 | 10.35 | 20 | 129902 | 1262 | 34825747 |
Abdominal discomfort | 13.45 | 10.35 | 304 | 129618 | 59531 | 34767478 |
Angiopathy | 13.41 | 10.35 | 40 | 129882 | 4133 | 34822876 |
Rhabdomyolysis | 13.40 | 10.35 | 340 | 129582 | 67823 | 34759186 |
Acute myeloid leukaemia | 13.40 | 10.35 | 30 | 129892 | 18240 | 34808769 |
Coma | 13.39 | 10.35 | 107 | 129815 | 45571 | 34781438 |
Osteitis deformans | 13.38 | 10.35 | 5 | 129917 | 30 | 34826979 |
Echocardiogram abnormal | 13.25 | 10.35 | 18 | 129904 | 1045 | 34825964 |
Intestinal angioedema | 13.15 | 10.35 | 9 | 129913 | 218 | 34826791 |
Basal cell carcinoma | 13.11 | 10.35 | 121 | 129801 | 19537 | 34807472 |
Bundle branch block right | 13.05 | 10.35 | 59 | 129863 | 7457 | 34819552 |
Pruritus | 13.04 | 10.35 | 649 | 129273 | 141332 | 34685677 |
Balance disorder | 13.03 | 10.35 | 218 | 129704 | 40436 | 34786573 |
Coronary artery bypass | 13.02 | 10.35 | 44 | 129878 | 4858 | 34822151 |
Gouty arthritis | 12.95 | 10.35 | 18 | 129904 | 1068 | 34825941 |
Renal artery restenosis | 12.89 | 10.35 | 4 | 129918 | 12 | 34826997 |
Hypercalciuria | 12.88 | 10.35 | 10 | 129912 | 296 | 34826713 |
Appendicitis | 12.87 | 10.35 | 22 | 129900 | 14785 | 34812224 |
Atrioventricular block second degree | 12.83 | 10.35 | 37 | 129885 | 3751 | 34823258 |
Pyelitis | 12.83 | 10.35 | 7 | 129915 | 111 | 34826898 |
Asthenia | 12.82 | 10.35 | 1068 | 128854 | 244183 | 34582826 |
Photosensitivity reaction | 12.71 | 10.35 | 75 | 129847 | 10519 | 34816490 |
Weaning failure | 12.66 | 10.35 | 9 | 129913 | 232 | 34826777 |
Meningitis streptococcal | 12.61 | 10.35 | 5 | 129917 | 36 | 34826973 |
Forced expiratory flow decreased | 12.56 | 10.35 | 8 | 129914 | 171 | 34826838 |
Hyperammonaemia | 12.56 | 10.35 | 4 | 129918 | 6363 | 34820646 |
Abnormal behaviour | 12.52 | 10.35 | 49 | 129873 | 24920 | 34802089 |
Respiratory depression | 12.48 | 10.35 | 26 | 129896 | 16219 | 34810790 |
Macular ischaemia | 12.47 | 10.35 | 6 | 129916 | 72 | 34826937 |
Fibrous histiocytoma | 12.44 | 10.35 | 8 | 129914 | 174 | 34826835 |
Electrocardiogram QT interval | 12.38 | 10.35 | 5 | 129917 | 38 | 34826971 |
High frequency ablation | 12.36 | 10.35 | 8 | 129914 | 176 | 34826833 |
Dermatosis | 12.26 | 10.35 | 10 | 129912 | 318 | 34826691 |
Hypoaesthesia | 12.23 | 10.35 | 307 | 129615 | 61137 | 34765872 |
Enterococcal infection | 12.18 | 10.35 | 10 | 129912 | 9296 | 34817713 |
Post procedural haematoma | 12.16 | 10.35 | 21 | 129901 | 1505 | 34825504 |
Hepatojugular reflux | 12.13 | 10.35 | 13 | 129909 | 588 | 34826421 |
Accelerated hypertension | 12.11 | 10.35 | 9 | 129913 | 249 | 34826760 |
Parotitis | 12.11 | 10.35 | 17 | 129905 | 1018 | 34825991 |
Urine albumin/creatinine ratio increased | 12.08 | 10.35 | 9 | 129913 | 250 | 34826759 |
Gastrointestinal mucosal necrosis | 12.05 | 10.35 | 8 | 129914 | 184 | 34826825 |
Cutaneous T-cell lymphoma | 12.04 | 10.35 | 21 | 129901 | 1517 | 34825492 |
Dermatomyositis | 12.04 | 10.35 | 19 | 129903 | 1264 | 34825745 |
Drug hypersensitivity | 11.91 | 10.35 | 219 | 129703 | 80310 | 34746699 |
Neutrophil count increased | 11.90 | 10.35 | 29 | 129893 | 17117 | 34809892 |
Mydriasis | 11.90 | 10.35 | 6 | 129916 | 7231 | 34819778 |
Electrocardiogram QT prolonged | 11.83 | 10.35 | 216 | 129706 | 40736 | 34786273 |
Productive cough | 11.83 | 10.35 | 87 | 129835 | 37726 | 34789283 |
Aortic valve stenosis | 11.79 | 10.35 | 29 | 129893 | 2674 | 34824335 |
Hypertensive heart disease | 11.77 | 10.35 | 27 | 129895 | 2381 | 34824628 |
Suture insertion | 11.65 | 10.35 | 5 | 129917 | 45 | 34826964 |
Atrioventricular block | 11.63 | 10.35 | 60 | 129862 | 8003 | 34819006 |
Device leakage | 11.51 | 10.35 | 5 | 129917 | 6570 | 34820439 |
Cataract nuclear | 11.50 | 10.35 | 12 | 129910 | 526 | 34826483 |
Peripheral vascular disorder | 11.49 | 10.35 | 43 | 129879 | 4993 | 34822016 |
Pemphigoid | 11.48 | 10.35 | 63 | 129859 | 8603 | 34818406 |
Vision blurred | 11.44 | 10.35 | 237 | 129685 | 45726 | 34781283 |
Gait disturbance | 11.41 | 10.35 | 405 | 129517 | 84735 | 34742274 |
Stenosis | 11.39 | 10.35 | 20 | 129902 | 1453 | 34825556 |
Device pacing issue | 11.37 | 10.35 | 5 | 129917 | 48 | 34826961 |
Myosclerosis | 11.34 | 10.35 | 9 | 129913 | 275 | 34826734 |
Immunoglobulin G4 related disease | 11.31 | 10.35 | 7 | 129915 | 142 | 34826867 |
Malaise | 11.27 | 10.35 | 570 | 129352 | 185255 | 34641754 |
Weight loss poor | 11.26 | 10.35 | 8 | 129914 | 206 | 34826803 |
Agranulocytosis | 11.16 | 10.35 | 48 | 129874 | 23773 | 34803236 |
Squamous cell carcinoma | 11.15 | 10.35 | 77 | 129845 | 11398 | 34815611 |
Lymphopenia | 11.05 | 10.35 | 28 | 129894 | 16307 | 34810702 |
Indifference | 11.02 | 10.35 | 7 | 129915 | 149 | 34826860 |
Thrombotic microangiopathy | 10.99 | 10.35 | 14 | 129908 | 10616 | 34816393 |
Oesophageal carcinoma | 10.98 | 10.35 | 11 | 129911 | 9293 | 34817716 |
Nail discolouration | 10.94 | 10.35 | 16 | 129906 | 995 | 34826014 |
Therapeutic response shortened | 10.94 | 10.35 | 7 | 129915 | 7397 | 34819612 |
Therapeutic response decreased | 10.91 | 10.35 | 64 | 129858 | 29249 | 34797760 |
Prothrombin time prolonged | 10.91 | 10.35 | 66 | 129856 | 9340 | 34817669 |
Renal function test abnormal | 10.88 | 10.35 | 27 | 129895 | 2503 | 34824506 |
Multiple-drug resistance | 10.86 | 10.35 | 3 | 129919 | 5236 | 34821773 |
Left ventricular dysfunction | 10.84 | 10.35 | 69 | 129853 | 9938 | 34817071 |
Constipation | 10.82 | 10.35 | 408 | 129514 | 136574 | 34690435 |
Emotional distress | 10.80 | 10.35 | 94 | 129828 | 14932 | 34812077 |
Lung disorder | 10.77 | 10.35 | 80 | 129842 | 34616 | 34792393 |
Nephropathy | 10.69 | 10.35 | 47 | 129875 | 5870 | 34821139 |
Rales | 10.62 | 10.35 | 68 | 129854 | 9815 | 34817194 |
Liver function test increased | 10.62 | 10.35 | 24 | 129898 | 14541 | 34812468 |
Anhidrosis | 10.58 | 10.35 | 6 | 129916 | 103 | 34826906 |
Loss of proprioception | 10.55 | 10.35 | 10 | 129912 | 390 | 34826619 |
Pneumothorax | 10.53 | 10.35 | 36 | 129886 | 19056 | 34807953 |
Schizophrenia | 10.51 | 10.35 | 10 | 129912 | 8656 | 34818353 |
Abdominal tenderness | 10.44 | 10.35 | 36 | 129886 | 4015 | 34822994 |
Posterior reversible encephalopathy syndrome | 10.40 | 10.35 | 13 | 129909 | 9941 | 34817068 |
Carotid arteriosclerosis | 10.40 | 10.35 | 22 | 129900 | 1836 | 34825173 |
Mechanical urticaria | 10.38 | 10.35 | 6 | 129916 | 107 | 34826902 |
Left ventricle outflow tract obstruction | 10.36 | 10.35 | 7 | 129915 | 166 | 34826843 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hyponatraemia | 1535.28 | 9.75 | 2512 | 289652 | 175336 | 79276888 |
Hypokalaemia | 677.86 | 9.75 | 1576 | 290588 | 142464 | 79309760 |
Angioedema | 537.18 | 9.75 | 984 | 291180 | 75051 | 79377173 |
Acute kidney injury | 471.89 | 9.75 | 3386 | 288778 | 516018 | 78936206 |
Off label use | 463.93 | 9.75 | 1737 | 290427 | 905478 | 78546746 |
Drug abuse | 332.59 | 9.75 | 92 | 292072 | 162599 | 79289625 |
Cerebrovascular accident | 319.58 | 9.75 | 1270 | 290894 | 154022 | 79298202 |
Myocardial infarction | 312.45 | 9.75 | 1420 | 290744 | 182709 | 79269515 |
Maternal exposure during pregnancy | 307.04 | 9.75 | 63 | 292101 | 136475 | 79315749 |
Hand deformity | 293.40 | 9.75 | 23 | 292141 | 103896 | 79348328 |
Pemphigus | 286.97 | 9.75 | 20 | 292144 | 99562 | 79352662 |
Blood pressure increased | 275.04 | 9.75 | 1512 | 290652 | 209848 | 79242376 |
Coronary artery disease | 265.62 | 9.75 | 677 | 291487 | 64797 | 79387427 |
Syncope | 249.92 | 9.75 | 1308 | 290856 | 178141 | 79274083 |
Blood potassium decreased | 228.52 | 9.75 | 518 | 291646 | 45994 | 79406230 |
Dizziness | 223.08 | 9.75 | 2924 | 289240 | 523517 | 78928707 |
Systemic lupus erythematosus | 221.92 | 9.75 | 83 | 292081 | 121066 | 79331158 |
Dehydration | 221.69 | 9.75 | 1613 | 290551 | 246574 | 79205650 |
Synovitis | 216.32 | 9.75 | 143 | 292021 | 150591 | 79301633 |
Drug ineffective | 216.16 | 9.75 | 2733 | 289431 | 1078180 | 78374044 |
Duodenal ulcer perforation | 207.38 | 9.75 | 8 | 292156 | 66203 | 79386021 |
Drug intolerance | 188.58 | 9.75 | 431 | 291733 | 263688 | 79188536 |
Glossodynia | 187.26 | 9.75 | 72 | 292092 | 103265 | 79348959 |
Product use in unapproved indication | 178.36 | 9.75 | 409 | 291755 | 249950 | 79202274 |
Blood glucose increased | 177.53 | 9.75 | 863 | 291301 | 114112 | 79338112 |
Treatment failure | 176.37 | 9.75 | 219 | 291945 | 170267 | 79281957 |
Hypotension | 171.27 | 9.75 | 2409 | 289755 | 437908 | 79014316 |
Lower respiratory tract infection | 164.27 | 9.75 | 139 | 292025 | 129081 | 79323143 |
Transient ischaemic attack | 162.40 | 9.75 | 493 | 291671 | 52202 | 79400022 |
Contraindicated product administered | 162.30 | 9.75 | 203 | 291961 | 157335 | 79294889 |
Exposure during pregnancy | 160.52 | 9.75 | 85 | 292079 | 101047 | 79351177 |
Cardiospasm | 156.12 | 9.75 | 115 | 292049 | 3186 | 79449038 |
Neutropenia | 154.71 | 9.75 | 538 | 291626 | 287172 | 79165052 |
Death | 154.15 | 9.75 | 1331 | 290833 | 565183 | 78887041 |
Febrile neutropenia | 151.44 | 9.75 | 394 | 291770 | 230605 | 79221619 |
Inappropriate antidiuretic hormone secretion | 146.24 | 9.75 | 308 | 291856 | 26005 | 79426219 |
Lactic acidosis | 144.26 | 9.75 | 575 | 291589 | 69784 | 79382440 |
Palmoplantar keratoderma | 144.02 | 9.75 | 115 | 292049 | 3601 | 79448623 |
Blood pressure inadequately controlled | 143.28 | 9.75 | 143 | 292021 | 6034 | 79446190 |
Atrial tachycardia | 129.62 | 9.75 | 145 | 292019 | 6988 | 79445236 |
Infection | 128.56 | 9.75 | 454 | 291710 | 241258 | 79210966 |
Sprue-like enteropathy | 127.39 | 9.75 | 72 | 292092 | 1246 | 79450978 |
Pruritus genital | 127.13 | 9.75 | 116 | 292048 | 4370 | 79447854 |
Pneumonia | 125.65 | 9.75 | 1685 | 290479 | 658561 | 78793663 |
Folliculitis | 125.61 | 9.75 | 25 | 292139 | 55355 | 79396869 |
Sleep terror | 123.85 | 9.75 | 114 | 292050 | 4344 | 79447880 |
Muscle injury | 123.42 | 9.75 | 16 | 292148 | 48545 | 79403679 |
Carotid artery occlusion | 123.06 | 9.75 | 146 | 292018 | 7501 | 79444723 |
Pancreatitis acute | 120.45 | 9.75 | 428 | 291736 | 49176 | 79403048 |
Sleep disorder due to general medical condition, insomnia type | 119.20 | 9.75 | 11 | 292153 | 43545 | 79408679 |
Milk-alkali syndrome | 117.16 | 9.75 | 70 | 292094 | 1350 | 79450874 |
Fall | 116.49 | 9.75 | 2467 | 289697 | 485162 | 78967062 |
Condition aggravated | 115.95 | 9.75 | 1225 | 290939 | 499899 | 78952325 |
Tension headache | 110.02 | 9.75 | 134 | 292030 | 7077 | 79445147 |
Pyrexia | 108.74 | 9.75 | 1791 | 290373 | 676918 | 78775306 |
Toxicity to various agents | 108.54 | 9.75 | 1004 | 291160 | 420536 | 79031688 |
Rheumatoid factor positive | 107.89 | 9.75 | 42 | 292122 | 59797 | 79392427 |
Anosmia | 107.72 | 9.75 | 147 | 292017 | 8697 | 79443527 |
Hypovolaemia | 107.66 | 9.75 | 215 | 291949 | 17476 | 79434748 |
Irritable bowel syndrome | 105.29 | 9.75 | 48 | 292116 | 62193 | 79390031 |
Product use issue | 104.42 | 9.75 | 405 | 291759 | 209417 | 79242807 |
Hypertensive crisis | 103.88 | 9.75 | 233 | 291931 | 20537 | 79431687 |
Sepsis | 103.85 | 9.75 | 571 | 291593 | 268857 | 79183367 |
Immunisation | 103.62 | 9.75 | 76 | 292088 | 2091 | 79450133 |
Cardiac failure congestive | 102.52 | 9.75 | 881 | 291283 | 141521 | 79310703 |
Chest pain | 100.66 | 9.75 | 1522 | 290642 | 280782 | 79171442 |
Helicobacter infection | 100.14 | 9.75 | 66 | 292098 | 69638 | 79382586 |
Therapeutic product effect decreased | 99.50 | 9.75 | 290 | 291874 | 163573 | 79288651 |
Arthropathy | 97.97 | 9.75 | 327 | 291837 | 176784 | 79275440 |
Hypochloraemia | 97.83 | 9.75 | 78 | 292086 | 2437 | 79449787 |
Cytomegalovirus infection | 97.24 | 9.75 | 19 | 292145 | 42625 | 79409599 |
Facial pain | 96.35 | 9.75 | 167 | 291997 | 12183 | 79440041 |
Myelosuppression | 96.11 | 9.75 | 16 | 292148 | 40280 | 79411944 |
Infusion related reaction | 93.70 | 9.75 | 479 | 291685 | 229758 | 79222466 |
Pericarditis | 93.70 | 9.75 | 148 | 292016 | 104088 | 79348136 |
Hepatic function abnormal | 91.24 | 9.75 | 80 | 292084 | 73027 | 79379197 |
Wound | 89.98 | 9.75 | 181 | 291983 | 115998 | 79336226 |
Discomfort | 86.36 | 9.75 | 209 | 291955 | 125408 | 79326816 |
Hypertension | 84.98 | 9.75 | 1693 | 290471 | 329299 | 79122925 |
Blister | 84.35 | 9.75 | 196 | 291968 | 119280 | 79332944 |
Hypertensive emergency | 82.83 | 9.75 | 74 | 292090 | 2711 | 79449513 |
Thrombocytopenia | 82.72 | 9.75 | 600 | 291564 | 264659 | 79187565 |
Stomatitis | 81.82 | 9.75 | 270 | 291894 | 146487 | 79305737 |
Renal failure | 81.76 | 9.75 | 1109 | 291055 | 199859 | 79252365 |
Palpitations | 81.73 | 9.75 | 765 | 291399 | 125845 | 79326379 |
Asthenia | 80.45 | 9.75 | 2448 | 289716 | 509241 | 78942983 |
Neutrophil count decreased | 79.26 | 9.75 | 139 | 292025 | 93820 | 79358404 |
Angina pectoris | 77.44 | 9.75 | 385 | 291779 | 51347 | 79400877 |
Intentional self-injury | 77.04 | 9.75 | 13 | 292151 | 32406 | 79419818 |
Joint swelling | 76.17 | 9.75 | 683 | 291481 | 287963 | 79164261 |
Blood sodium decreased | 75.70 | 9.75 | 281 | 291883 | 32974 | 79419250 |
Alopecia | 74.72 | 9.75 | 518 | 291646 | 230837 | 79221387 |
Gastrooesophageal reflux disease | 72.43 | 9.75 | 640 | 291524 | 103606 | 79348618 |
Therapy non-responder | 72.16 | 9.75 | 143 | 292021 | 92162 | 79360062 |
Lung diffusion test abnormal | 72.04 | 9.75 | 33 | 292131 | 357 | 79451867 |
Blood pressure systolic increased | 70.15 | 9.75 | 453 | 291711 | 66533 | 79385691 |
Bundle branch block left | 67.77 | 9.75 | 138 | 292026 | 11375 | 79440849 |
Abortion spontaneous | 67.59 | 9.75 | 13 | 292151 | 29494 | 79422730 |
Blood urea increased | 67.38 | 9.75 | 355 | 291809 | 48435 | 79403789 |
Angina unstable | 66.07 | 9.75 | 170 | 291994 | 16357 | 79435867 |
Drug resistance | 64.76 | 9.75 | 37 | 292127 | 42176 | 79410048 |
C-reactive protein abnormal | 63.97 | 9.75 | 50 | 292114 | 48317 | 79403907 |
Disease progression | 63.94 | 9.75 | 404 | 291760 | 183958 | 79268266 |
Hypercalcaemia | 63.30 | 9.75 | 294 | 291870 | 38136 | 79414088 |
Drug interaction | 62.98 | 9.75 | 1978 | 290186 | 413205 | 79039019 |
Hyperlipidaemia | 62.36 | 9.75 | 224 | 291940 | 25869 | 79426355 |
Pain of skin | 62.27 | 9.75 | 154 | 292010 | 14459 | 79437765 |
Swelling | 61.98 | 9.75 | 502 | 291662 | 216209 | 79236015 |
Blood creatinine increased | 61.55 | 9.75 | 852 | 291312 | 154205 | 79298019 |
Cytokine release syndrome | 60.51 | 9.75 | 28 | 292136 | 35970 | 79416254 |
Hyperkalaemia | 59.37 | 9.75 | 661 | 291503 | 113737 | 79338487 |
Pregnancy | 59.08 | 9.75 | 13 | 292151 | 26838 | 79425386 |
Hepatic enzyme increased | 58.88 | 9.75 | 409 | 291755 | 182201 | 79270023 |
Sinus bradycardia | 58.87 | 9.75 | 215 | 291949 | 25032 | 79427192 |
Leukopenia | 58.50 | 9.75 | 224 | 291940 | 116289 | 79335935 |
Pancreatitis | 57.86 | 9.75 | 440 | 291724 | 68135 | 79384089 |
Interstitial lung disease | 57.49 | 9.75 | 215 | 291949 | 112385 | 79339839 |
Orthostatic intolerance | 56.98 | 9.75 | 51 | 292113 | 1873 | 79450351 |
Malignant neoplasm progression | 56.38 | 9.75 | 281 | 291883 | 135709 | 79316515 |
Subarachnoid haemorrhage | 55.91 | 9.75 | 207 | 291957 | 24258 | 79427966 |
Red blood cell sedimentation rate abnormal | 55.52 | 9.75 | 6 | 292158 | 20957 | 79431267 |
Product complaint | 55.11 | 9.75 | 139 | 292025 | 13210 | 79439014 |
Mobility decreased | 54.43 | 9.75 | 246 | 291918 | 121929 | 79330295 |
Blood pressure diastolic decreased | 54.14 | 9.75 | 237 | 291927 | 29979 | 79422245 |
Carotid artery stenosis | 53.97 | 9.75 | 107 | 292057 | 8651 | 79443573 |
Intentional product use issue | 53.42 | 9.75 | 332 | 291832 | 151780 | 79300444 |
Platelet count decreased | 53.36 | 9.75 | 456 | 291708 | 194208 | 79258016 |
Live birth | 53.31 | 9.75 | 4 | 292160 | 18740 | 79433484 |
Loss of employment | 52.96 | 9.75 | 56 | 292108 | 2531 | 79449693 |
Blood chloride decreased | 52.93 | 9.75 | 102 | 292062 | 8075 | 79444149 |
Bronchopulmonary aspergillosis | 52.84 | 9.75 | 9 | 292155 | 22285 | 79429939 |
Impaired healing | 51.84 | 9.75 | 157 | 292007 | 87498 | 79364726 |
Oedema peripheral | 51.80 | 9.75 | 1250 | 290914 | 251038 | 79201186 |
Pancytopenia | 51.59 | 9.75 | 375 | 291789 | 165370 | 79286854 |
Acute myocardial infarction | 50.97 | 9.75 | 468 | 291696 | 76568 | 79375656 |
Hypoglycaemia | 50.44 | 9.75 | 582 | 291582 | 101012 | 79351212 |
IgM nephropathy | 50.41 | 9.75 | 19 | 292145 | 119 | 79452105 |
Psoriatic arthropathy | 49.57 | 9.75 | 135 | 292029 | 77864 | 79374360 |
Eye pruritus | 49.51 | 9.75 | 177 | 291987 | 20393 | 79431831 |
Bone marrow failure | 49.39 | 9.75 | 69 | 292095 | 51038 | 79401186 |
Ventricular hypertrophy | 49.21 | 9.75 | 90 | 292074 | 6848 | 79445376 |
Bradycardia | 49.08 | 9.75 | 733 | 291431 | 134824 | 79317400 |
Mitral valve incompetence | 48.13 | 9.75 | 220 | 291944 | 28345 | 79423879 |
Arterial occlusive disease | 47.00 | 9.75 | 99 | 292065 | 8357 | 79443867 |
Hypersensitivity | 45.87 | 9.75 | 680 | 291484 | 261559 | 79190665 |
Diplopia | 45.86 | 9.75 | 243 | 291921 | 33223 | 79419001 |
Renal artery stenosis | 45.66 | 9.75 | 60 | 292104 | 3422 | 79448802 |
5-hydroxyindolacetic acid in urine increased | 44.99 | 9.75 | 21 | 292143 | 238 | 79451986 |
Septic shock | 44.70 | 9.75 | 265 | 291899 | 122536 | 79329688 |
Product monitoring error | 44.63 | 9.75 | 100 | 292064 | 8806 | 79443418 |
Intestinal angioedema | 44.57 | 9.75 | 32 | 292132 | 851 | 79451373 |
Atrial fibrillation | 44.48 | 9.75 | 993 | 291171 | 196893 | 79255331 |
Electrolyte imbalance | 44.23 | 9.75 | 227 | 291937 | 30654 | 79421570 |
Blood mercury abnormal | 43.85 | 9.75 | 20 | 292144 | 214 | 79452010 |
Hyperhidrosis | 43.65 | 9.75 | 789 | 291375 | 150703 | 79301521 |
Multiple organ dysfunction syndrome | 43.50 | 9.75 | 260 | 291904 | 119986 | 79332238 |
Rhabdomyolysis | 42.68 | 9.75 | 571 | 291593 | 102560 | 79349664 |
Sopor | 42.56 | 9.75 | 35 | 292129 | 32975 | 79419249 |
Glycosylated haemoglobin increased | 42.38 | 9.75 | 161 | 292003 | 19099 | 79433125 |
Ventricular tachycardia | 42.32 | 9.75 | 281 | 291883 | 41654 | 79410570 |
Myocardial ischaemia | 41.86 | 9.75 | 195 | 291969 | 25324 | 79426900 |
Amnesia | 41.67 | 9.75 | 383 | 291781 | 62674 | 79389550 |
Rash papular | 41.65 | 9.75 | 175 | 291989 | 21741 | 79430483 |
Blindness | 41.60 | 9.75 | 210 | 291954 | 28173 | 79424051 |
Arrhythmia | 41.43 | 9.75 | 374 | 291790 | 60898 | 79391326 |
Hypomagnesaemia | 41.27 | 9.75 | 304 | 291860 | 46607 | 79405617 |
Hip arthroplasty | 41.24 | 9.75 | 42 | 292122 | 35714 | 79416510 |
Epstein-Barr virus infection | 41.22 | 9.75 | 3 | 292161 | 14413 | 79437811 |
Metabolic alkalosis | 40.78 | 9.75 | 65 | 292099 | 4424 | 79447800 |
Cardiomegaly | 40.78 | 9.75 | 198 | 291966 | 26154 | 79426070 |
Pemphigoid | 40.53 | 9.75 | 136 | 292028 | 15179 | 79437045 |
Hospitalisation | 40.05 | 9.75 | 193 | 291971 | 94043 | 79358181 |
Lip swelling | 40.00 | 9.75 | 272 | 291892 | 40639 | 79411585 |
Eosinophilic bronchitis | 39.94 | 9.75 | 24 | 292140 | 468 | 79451756 |
Swollen tongue | 39.84 | 9.75 | 280 | 291884 | 42290 | 79409934 |
Atrioventricular block first degree | 39.54 | 9.75 | 118 | 292046 | 12373 | 79439851 |
Arteriosclerosis coronary artery | 39.26 | 9.75 | 149 | 292015 | 17667 | 79434557 |
Emotional distress | 39.24 | 9.75 | 266 | 291898 | 39703 | 79412521 |
Vasculitis | 39.12 | 9.75 | 189 | 291975 | 24913 | 79427311 |
Drug ineffective for unapproved indication | 38.66 | 9.75 | 81 | 292083 | 51157 | 79401067 |
Nausea | 38.38 | 9.75 | 4035 | 288129 | 953161 | 78499063 |
Sedation | 38.35 | 9.75 | 83 | 292081 | 51812 | 79400412 |
Haemophagocytic lymphohistiocytosis | 38.26 | 9.75 | 16 | 292148 | 21821 | 79430403 |
Ill-defined disorder | 38.23 | 9.75 | 119 | 292045 | 65756 | 79386468 |
Supraventricular extrasystoles | 37.91 | 9.75 | 81 | 292083 | 6906 | 79445318 |
Tinnitus | 37.70 | 9.75 | 285 | 291879 | 44048 | 79408176 |
Choroidal effusion | 37.57 | 9.75 | 26 | 292138 | 651 | 79451573 |
Anhedonia | 37.41 | 9.75 | 130 | 292034 | 14768 | 79437456 |
Arteriosclerosis | 37.37 | 9.75 | 149 | 292015 | 18078 | 79434146 |
Lymphocyte count decreased | 37.18 | 9.75 | 73 | 292091 | 47216 | 79405008 |
C-reactive protein increased | 36.81 | 9.75 | 299 | 291865 | 128728 | 79323496 |
Liver injury | 36.72 | 9.75 | 97 | 292067 | 56517 | 79395707 |
Pneumocystis jirovecii pneumonia | 36.57 | 9.75 | 39 | 292125 | 32469 | 79419755 |
Hypophagia | 36.55 | 9.75 | 288 | 291876 | 45079 | 79407145 |
Acute myeloid leukaemia | 35.94 | 9.75 | 36 | 292128 | 30849 | 79421375 |
Graft versus host disease | 35.76 | 9.75 | 6 | 292158 | 15020 | 79437204 |
Fibromyalgia | 34.73 | 9.75 | 120 | 292044 | 64220 | 79388004 |
Liver disorder | 34.58 | 9.75 | 142 | 292022 | 72275 | 79379949 |
Neurotoxicity | 34.41 | 9.75 | 41 | 292123 | 32477 | 79419747 |
Rash | 34.40 | 9.75 | 1750 | 290414 | 576608 | 78875616 |
Bacteraemia | 34.09 | 9.75 | 42 | 292122 | 32782 | 79419442 |
Muscle twitching | 34.06 | 9.75 | 180 | 291984 | 24584 | 79427640 |
Disseminated intravascular coagulation | 34.02 | 9.75 | 49 | 292115 | 35793 | 79416431 |
Allergic oedema | 33.95 | 9.75 | 26 | 292138 | 765 | 79451459 |
Dystonia | 33.92 | 9.75 | 18 | 292146 | 21381 | 79430843 |
Sedation complication | 33.65 | 9.75 | 8 | 292156 | 15661 | 79436563 |
Systemic infection | 33.64 | 9.75 | 95 | 292069 | 9657 | 79442567 |
Aspergillus infection | 33.63 | 9.75 | 14 | 292150 | 19147 | 79433077 |
White blood cell count decreased | 33.34 | 9.75 | 487 | 291677 | 187801 | 79264423 |
Neutropenic sepsis | 33.30 | 9.75 | 30 | 292134 | 27034 | 79425190 |
Intestinal villi atrophy | 33.29 | 9.75 | 21 | 292143 | 448 | 79451776 |
Infective pulmonary exacerbation of cystic fibrosis | 33.22 | 9.75 | 4 | 292160 | 12847 | 79439377 |
Haematotoxicity | 33.17 | 9.75 | 8 | 292156 | 15511 | 79436713 |
Dry skin | 33.07 | 9.75 | 388 | 291776 | 67607 | 79384617 |
Pulmonary valve disease | 32.98 | 9.75 | 18 | 292146 | 290 | 79451934 |
Renal injury | 32.82 | 9.75 | 136 | 292028 | 16791 | 79435433 |
Disorientation | 32.22 | 9.75 | 362 | 291802 | 62414 | 79389810 |
Rotator cuff syndrome | 31.99 | 9.75 | 119 | 292045 | 13976 | 79438248 |
Bronchomalacia | 31.93 | 9.75 | 17 | 292147 | 260 | 79451964 |
Cataract | 31.79 | 9.75 | 358 | 291806 | 61762 | 79390462 |
Actinic keratosis | 31.59 | 9.75 | 69 | 292095 | 5973 | 79446251 |
Anxiety | 31.54 | 9.75 | 1160 | 291004 | 247352 | 79204872 |
Feeling abnormal | 31.51 | 9.75 | 785 | 291379 | 158414 | 79293810 |
Atrioventricular block | 31.42 | 9.75 | 118 | 292046 | 13923 | 79438301 |
Transplant rejection | 31.33 | 9.75 | 16 | 292148 | 19421 | 79432803 |
Pericardial disease | 31.31 | 9.75 | 22 | 292142 | 565 | 79451659 |
Heart rate increased | 31.07 | 9.75 | 618 | 291546 | 120106 | 79332118 |
Fear | 31.06 | 9.75 | 161 | 292003 | 21825 | 79430399 |
Gastrointestinal disorder | 30.96 | 9.75 | 292 | 291872 | 121913 | 79330311 |
Product prescribing error | 30.53 | 9.75 | 274 | 291890 | 44539 | 79407685 |
Granulomatous pneumonitis | 30.24 | 9.75 | 12 | 292152 | 88 | 79452136 |
Premature delivery | 30.10 | 9.75 | 25 | 292139 | 23442 | 79428782 |
Therapy partial responder | 30.08 | 9.75 | 13 | 292151 | 17384 | 79434840 |
Epilepsy | 29.66 | 9.75 | 66 | 292098 | 40794 | 79411430 |
Abdominal discomfort | 29.27 | 9.75 | 697 | 291467 | 250030 | 79202194 |
Nasopharyngitis | 29.02 | 9.75 | 708 | 291456 | 253173 | 79199051 |
Cardiac disorder | 28.84 | 9.75 | 368 | 291796 | 65389 | 79386835 |
Large intestine polyp | 28.60 | 9.75 | 107 | 292057 | 12601 | 79439623 |
Disturbance in attention | 28.41 | 9.75 | 298 | 291866 | 50503 | 79401721 |
Overdose | 28.40 | 9.75 | 489 | 291675 | 183717 | 79268507 |
Cytopenia | 28.33 | 9.75 | 20 | 292144 | 20363 | 79431861 |
Essential hypertension | 28.16 | 9.75 | 66 | 292098 | 5987 | 79446237 |
Mucosal inflammation | 28.08 | 9.75 | 162 | 292002 | 75418 | 79376806 |
Photosensitivity reaction | 27.99 | 9.75 | 152 | 292012 | 20975 | 79431249 |
Immune reconstitution inflammatory syndrome | 27.94 | 9.75 | 8 | 292156 | 13833 | 79438391 |
Hypertensive heart disease | 27.88 | 9.75 | 53 | 292111 | 4153 | 79448071 |
Mental status changes | 27.81 | 9.75 | 371 | 291793 | 66588 | 79385636 |
Aggression | 27.53 | 9.75 | 95 | 292069 | 50863 | 79401361 |
Venoocclusive liver disease | 27.36 | 9.75 | 5 | 292159 | 11766 | 79440458 |
Vertigo | 27.15 | 9.75 | 379 | 291785 | 68703 | 79383521 |
Kidney transplant rejection | 26.96 | 9.75 | 3 | 292161 | 10243 | 79441981 |
Ventricular extrasystoles | 26.95 | 9.75 | 143 | 292021 | 19561 | 79432663 |
Gout | 26.91 | 9.75 | 169 | 291995 | 24580 | 79427644 |
Weight decreased | 26.88 | 9.75 | 1574 | 290590 | 353624 | 79098600 |
Prescribed overdose | 26.84 | 9.75 | 62 | 292102 | 37821 | 79414403 |
Pernicious anaemia | 26.48 | 9.75 | 20 | 292144 | 576 | 79451648 |
Polydipsia | 26.46 | 9.75 | 68 | 292096 | 6537 | 79445687 |
Muscular weakness | 26.24 | 9.75 | 773 | 291391 | 159956 | 79292268 |
Macular degeneration | 26.17 | 9.75 | 96 | 292068 | 11200 | 79441024 |
Respiratory depression | 26.00 | 9.75 | 38 | 292126 | 27592 | 79424632 |
Left ventricular hypertrophy | 25.83 | 9.75 | 95 | 292069 | 11096 | 79441128 |
Cutaneous T-cell lymphoma | 25.75 | 9.75 | 40 | 292124 | 2663 | 79449561 |
Toxic epidermal necrolysis | 25.54 | 9.75 | 81 | 292083 | 44500 | 79407724 |
Interstitial granulomatous dermatitis | 25.52 | 9.75 | 14 | 292150 | 228 | 79451996 |
Fluid intake reduced | 25.46 | 9.75 | 65 | 292099 | 6223 | 79446001 |
Hypogammaglobulinaemia | 25.21 | 9.75 | 8 | 292156 | 12943 | 79439281 |
Basal cell carcinoma | 25.19 | 9.75 | 228 | 291936 | 37147 | 79415077 |
Mydriasis | 24.94 | 9.75 | 17 | 292147 | 17626 | 79434598 |
Physical examination abnormal | 24.89 | 9.75 | 15 | 292149 | 294 | 79451930 |
Visual impairment | 24.85 | 9.75 | 475 | 291689 | 91656 | 79360568 |
Tendon rupture | 24.76 | 9.75 | 99 | 292065 | 12027 | 79440197 |
Erectile dysfunction | 24.75 | 9.75 | 113 | 292051 | 14551 | 79437673 |
Electrocardiogram ST segment depression | 24.70 | 9.75 | 55 | 292109 | 4823 | 79447401 |
Peripheral vascular disorder | 24.61 | 9.75 | 75 | 292089 | 7955 | 79444269 |
Microalbuminuria | 24.58 | 9.75 | 23 | 292141 | 895 | 79451329 |
Device related thrombosis | 24.58 | 9.75 | 39 | 292125 | 2644 | 79449580 |
Gastric disorder | 24.55 | 9.75 | 227 | 291937 | 37206 | 79415018 |
Schizophrenia | 24.46 | 9.75 | 13 | 292151 | 15427 | 79436797 |
Drug-induced liver injury | 24.41 | 9.75 | 142 | 292022 | 65975 | 79386249 |
Extrasystoles | 24.36 | 9.75 | 71 | 292093 | 7348 | 79444876 |
Vascular purpura | 24.31 | 9.75 | 42 | 292122 | 3056 | 79449168 |
Pleural effusion | 24.24 | 9.75 | 380 | 291784 | 144882 | 79307342 |
Low density lipoprotein decreased | 24.23 | 9.75 | 26 | 292138 | 1195 | 79451029 |
Bone erosion | 24.17 | 9.75 | 18 | 292146 | 17829 | 79434395 |
Thrombotic microangiopathy | 24.05 | 9.75 | 23 | 292141 | 20146 | 79432078 |
Electrocardiogram abnormal | 23.94 | 9.75 | 123 | 292041 | 16614 | 79435610 |
Blood pressure decreased | 23.89 | 9.75 | 504 | 291660 | 98962 | 79353262 |
Device related infection | 23.60 | 9.75 | 57 | 292107 | 34237 | 79417987 |
Anti-neutrophil cytoplasmic antibody positive vasculitis | 23.51 | 9.75 | 46 | 292118 | 3683 | 79448541 |
Autoimmune disorder | 23.49 | 9.75 | 16 | 292148 | 16596 | 79435628 |
Drug hypersensitivity | 23.42 | 9.75 | 877 | 291287 | 298039 | 79154185 |
Distributive shock | 23.17 | 9.75 | 38 | 292126 | 2649 | 79449575 |
Hyperammonaemia | 23.17 | 9.75 | 6 | 292158 | 11087 | 79441137 |
Diverticulum | 23.10 | 9.75 | 112 | 292052 | 14784 | 79437440 |
Tricuspid valve incompetence | 22.94 | 9.75 | 137 | 292027 | 19575 | 79432649 |
Depressed level of consciousness | 22.78 | 9.75 | 235 | 291929 | 96417 | 79355807 |
Myelodysplastic syndrome | 22.78 | 9.75 | 48 | 292116 | 30253 | 79421971 |
Dilatation atrial | 22.52 | 9.75 | 45 | 292119 | 3659 | 79448565 |
Bladder prolapse | 22.25 | 9.75 | 27 | 292137 | 1420 | 79450804 |
Blood creatine phosphokinase increased | 22.23 | 9.75 | 353 | 291811 | 65737 | 79386487 |
Myalgia | 22.22 | 9.75 | 861 | 291303 | 184780 | 79267444 |
Atrioventricular block second degree | 22.13 | 9.75 | 68 | 292096 | 7244 | 79444980 |
Myopathy | 22.10 | 9.75 | 140 | 292024 | 20423 | 79431801 |
Facet joint syndrome | 21.97 | 9.75 | 7 | 292157 | 11295 | 79440929 |
Dysgeusia | 21.79 | 9.75 | 312 | 291852 | 56865 | 79395359 |
Lymphopenia | 21.66 | 9.75 | 50 | 292114 | 30507 | 79421717 |
Occult blood | 21.53 | 9.75 | 29 | 292135 | 1694 | 79450530 |
Lacunar infarction | 21.50 | 9.75 | 59 | 292105 | 5898 | 79446326 |
Non-cardiogenic pulmonary oedema | 21.49 | 9.75 | 27 | 292137 | 1472 | 79450752 |
Gangrene | 21.46 | 9.75 | 77 | 292087 | 8887 | 79443337 |
Musculoskeletal stiffness | 21.39 | 9.75 | 483 | 291681 | 174525 | 79277699 |
Orthostatic hypotension | 21.22 | 9.75 | 306 | 291858 | 55858 | 79396366 |
Liver function test increased | 20.91 | 9.75 | 75 | 292089 | 39698 | 79412526 |
Pancreatitis necrotising | 20.85 | 9.75 | 45 | 292119 | 3863 | 79448361 |
Coronary artery occlusion | 20.84 | 9.75 | 111 | 292053 | 15204 | 79437020 |
Bundle branch block right | 20.73 | 9.75 | 89 | 292075 | 11162 | 79441062 |
Neurosensory hypoacusis | 20.72 | 9.75 | 12 | 292152 | 218 | 79452006 |
Grip strength decreased | 20.66 | 9.75 | 30 | 292134 | 21839 | 79430385 |
Low density lipoprotein increased | 20.59 | 9.75 | 74 | 292090 | 8548 | 79443676 |
Intentional overdose | 20.56 | 9.75 | 269 | 291895 | 105691 | 79346533 |
Cardiac murmur | 20.39 | 9.75 | 113 | 292051 | 15711 | 79436513 |
Angle closure glaucoma | 20.35 | 9.75 | 38 | 292126 | 2938 | 79449286 |
Renal tubular necrosis | 20.19 | 9.75 | 159 | 292005 | 24880 | 79427344 |
Hepatic steatosis | 20.00 | 9.75 | 219 | 291945 | 37519 | 79414705 |
Multiple-drug resistance | 19.92 | 9.75 | 4 | 292160 | 8804 | 79443420 |
Breast cancer stage II | 19.87 | 9.75 | 3 | 292161 | 8117 | 79444107 |
Osteonecrosis of jaw | 19.87 | 9.75 | 86 | 292078 | 43140 | 79409084 |
Intervertebral disc degeneration | 19.86 | 9.75 | 112 | 292052 | 15673 | 79436551 |
Acute coronary syndrome | 19.77 | 9.75 | 139 | 292025 | 20994 | 79431230 |
Lung disorder | 19.76 | 9.75 | 194 | 291970 | 80363 | 79371861 |
Sinusitis | 19.74 | 9.75 | 555 | 291609 | 194946 | 79257278 |
Diverticulitis | 19.69 | 9.75 | 256 | 291908 | 45680 | 79406544 |
Nervousness | 19.63 | 9.75 | 198 | 291966 | 33217 | 79419007 |
Substance abuse | 19.62 | 9.75 | 7 | 292157 | 10519 | 79441705 |
Acquired acrodermatitis enteropathica | 19.62 | 9.75 | 5 | 292159 | 5 | 79452219 |
Endometrial cancer stage I | 19.58 | 9.75 | 11 | 292153 | 188 | 79452036 |
Aplastic anaemia | 19.57 | 9.75 | 22 | 292142 | 17883 | 79434341 |
Colorectal cancer | 19.40 | 9.75 | 4 | 292160 | 8643 | 79443581 |
Adverse drug reaction | 19.32 | 9.75 | 153 | 292011 | 66239 | 79385985 |
Renal artery stent placement | 19.25 | 9.75 | 8 | 292156 | 67 | 79452157 |
Polyuria | 19.21 | 9.75 | 107 | 292057 | 14907 | 79437317 |
Muscle spasms | 19.19 | 9.75 | 803 | 291361 | 173927 | 79278297 |
Vaginal flatulence | 19.02 | 9.75 | 34 | 292130 | 2541 | 79449683 |
Peritonitis | 18.98 | 9.75 | 47 | 292117 | 27989 | 79424235 |
Coronary artery bypass | 18.94 | 9.75 | 57 | 292107 | 6005 | 79446219 |
Gouty arthritis | 18.89 | 9.75 | 25 | 292139 | 1436 | 79450788 |
Chronic sinusitis | 18.82 | 9.75 | 96 | 292068 | 12930 | 79439294 |
Tooth erosion | 18.81 | 9.75 | 14 | 292150 | 394 | 79451830 |
Disability | 18.75 | 9.75 | 21 | 292143 | 17099 | 79435125 |
Pathogen resistance | 18.74 | 9.75 | 15 | 292149 | 14327 | 79437897 |
Progressive multifocal leukoencephalopathy | 18.74 | 9.75 | 29 | 292135 | 20571 | 79431653 |
Memory impairment | 18.68 | 9.75 | 539 | 291625 | 111195 | 79341029 |
Poisoning deliberate | 18.61 | 9.75 | 25 | 292139 | 18803 | 79433421 |
Vulvovaginal burning sensation | 18.38 | 9.75 | 26 | 292138 | 1591 | 79450633 |
Respiratory tract inflammation | 18.14 | 9.75 | 19 | 292145 | 849 | 79451375 |
Erythrodermic psoriasis | 18.14 | 9.75 | 27 | 292137 | 1731 | 79450493 |
Agranulocytosis | 18.11 | 9.75 | 94 | 292070 | 44936 | 79407288 |
Diastolic dysfunction | 18.01 | 9.75 | 83 | 292081 | 10728 | 79441496 |
Heart rate irregular | 17.94 | 9.75 | 191 | 291973 | 32488 | 79419736 |
Hip fracture | 17.94 | 9.75 | 182 | 291982 | 30579 | 79421645 |
Meniere's disease | 17.85 | 9.75 | 10 | 292154 | 170 | 79452054 |
Meniscus injury | 17.82 | 9.75 | 60 | 292104 | 6708 | 79445516 |
Fear of injection | 17.75 | 9.75 | 3 | 292161 | 7471 | 79444753 |
Adenocarcinoma | 17.67 | 9.75 | 42 | 292122 | 3844 | 79448380 |
Pharyngeal oedema | 17.62 | 9.75 | 111 | 292053 | 16161 | 79436063 |
Foetal death | 17.48 | 9.75 | 4 | 292160 | 8040 | 79444184 |
Polymyalgia rheumatica | 17.45 | 9.75 | 46 | 292118 | 4491 | 79447733 |
Oropharyngeal swelling | 17.43 | 9.75 | 23 | 292141 | 1317 | 79450907 |
Muscle necrosis | 17.40 | 9.75 | 24 | 292140 | 1434 | 79450790 |
Respiratory failure | 17.40 | 9.75 | 517 | 291647 | 180394 | 79271830 |
Multiple drug therapy | 17.40 | 9.75 | 43 | 292121 | 4035 | 79448189 |
Withdrawal hypertension | 17.31 | 9.75 | 13 | 292151 | 371 | 79451853 |
Pollakiuria | 17.29 | 9.75 | 211 | 291953 | 37106 | 79415118 |
Cystitis haemorrhagic | 17.27 | 9.75 | 6 | 292158 | 9166 | 79443058 |
Metastases to fallopian tube | 17.22 | 9.75 | 7 | 292157 | 55 | 79452169 |
Depression | 17.21 | 9.75 | 965 | 291199 | 215825 | 79236399 |
Polyp | 17.21 | 9.75 | 67 | 292097 | 8040 | 79444184 |
Rhinovirus infection | 17.20 | 9.75 | 4 | 292160 | 7949 | 79444275 |
Choroidal detachment | 17.16 | 9.75 | 16 | 292148 | 620 | 79451604 |
Breast neoplasm | 17.03 | 9.75 | 19 | 292145 | 913 | 79451311 |
Device expulsion | 17.00 | 9.75 | 44 | 292120 | 25817 | 79426407 |
Uveitis | 16.99 | 9.75 | 22 | 292142 | 16808 | 79435416 |
Torsade de pointes | 16.90 | 9.75 | 125 | 292039 | 19187 | 79433037 |
Blood creatine increased | 16.81 | 9.75 | 74 | 292090 | 9381 | 79442843 |
Paradoxical drug reaction | 16.81 | 9.75 | 3 | 292161 | 7182 | 79445042 |
Renovascular hypertension | 16.80 | 9.75 | 7 | 292157 | 59 | 79452165 |
Enterocolitis | 16.79 | 9.75 | 17 | 292147 | 14495 | 79437729 |
Joint range of motion decreased | 16.69 | 9.75 | 64 | 292100 | 33218 | 79419006 |
Hepatic neoplasm | 16.65 | 9.75 | 38 | 292126 | 3388 | 79448836 |
Miosis | 16.61 | 9.75 | 20 | 292144 | 15769 | 79436455 |
Peripheral swelling | 16.52 | 9.75 | 813 | 291351 | 268804 | 79183420 |
Cutaneous lupus erythematosus | 16.51 | 9.75 | 35 | 292129 | 2968 | 79449256 |
Aortic valve incompetence | 16.50 | 9.75 | 74 | 292090 | 9456 | 79442768 |
Hypertensive angiopathy | 16.45 | 9.75 | 8 | 292156 | 100 | 79452124 |
Lower limb fracture | 16.44 | 9.75 | 38 | 292126 | 23177 | 79429047 |
Thalamic infarction | 16.34 | 9.75 | 22 | 292142 | 1285 | 79450939 |
Tumour lysis syndrome | 16.31 | 9.75 | 40 | 292124 | 23899 | 79428325 |
Osteoarthritis | 16.23 | 9.75 | 427 | 291737 | 86882 | 79365342 |
Crystal arthropathy | 16.20 | 9.75 | 10 | 292154 | 205 | 79452019 |
Product quality issue | 16.20 | 9.75 | 193 | 291971 | 33747 | 79418477 |
Hemiparesis | 16.18 | 9.75 | 192 | 291972 | 33541 | 79418683 |
Injection site inflammation | 16.00 | 9.75 | 41 | 292123 | 3935 | 79448289 |
Gait disturbance | 15.95 | 9.75 | 921 | 291243 | 206585 | 79245639 |
Blood lactic acid decreased | 15.91 | 9.75 | 11 | 292153 | 275 | 79451949 |
Rhinalgia | 15.91 | 9.75 | 30 | 292134 | 2337 | 79449887 |
Mandibular mass | 15.91 | 9.75 | 10 | 292154 | 212 | 79452012 |
Lichen planus | 15.89 | 9.75 | 33 | 292131 | 2758 | 79449466 |
Neurofibrosarcoma | 15.82 | 9.75 | 10 | 292154 | 214 | 79452010 |
Osteogenesis imperfecta | 15.81 | 9.75 | 14 | 292150 | 507 | 79451717 |
Allergic cough | 15.80 | 9.75 | 16 | 292148 | 687 | 79451537 |
Vascular device infection | 15.77 | 9.75 | 9 | 292155 | 10267 | 79441957 |
Delirium | 15.63 | 9.75 | 217 | 291947 | 84410 | 79367814 |
Clostridium difficile infection | 15.58 | 9.75 | 92 | 292072 | 42593 | 79409631 |
Blood triglycerides increased | 15.56 | 9.75 | 131 | 292033 | 20909 | 79431315 |
Cell death | 15.45 | 9.75 | 45 | 292119 | 4654 | 79447570 |
Nephrocalcinosis | 15.40 | 9.75 | 23 | 292141 | 1479 | 79450745 |
Tooth abscess | 15.39 | 9.75 | 107 | 292057 | 16103 | 79436121 |
Shoshin beriberi | 15.34 | 9.75 | 7 | 292157 | 75 | 79452149 |
Ascites | 15.33 | 9.75 | 190 | 291974 | 75372 | 79376852 |
Enterococcal infection | 15.27 | 9.75 | 21 | 292143 | 15639 | 79436585 |
Endometrial hyperplasia | 15.26 | 9.75 | 15 | 292149 | 621 | 79451603 |
Psychotic disorder | 15.24 | 9.75 | 89 | 292075 | 41313 | 79410911 |
Mucosal membrane hyperplasia | 15.24 | 9.75 | 6 | 292158 | 43 | 79452181 |
Accidental exposure to product | 15.21 | 9.75 | 61 | 292103 | 31261 | 79420963 |
Adverse event | 15.19 | 9.75 | 144 | 292020 | 60070 | 79392154 |
Pruritus allergic | 15.18 | 9.75 | 22 | 292142 | 1377 | 79450847 |
Rectal prolapse | 15.13 | 9.75 | 28 | 292136 | 2150 | 79450074 |
Renin increased | 15.04 | 9.75 | 10 | 292154 | 234 | 79451990 |
Pseudomonas infection | 14.98 | 9.75 | 34 | 292130 | 20869 | 79431355 |
Heart rate decreased | 14.89 | 9.75 | 350 | 291814 | 69966 | 79382258 |
Knee arthroplasty | 14.86 | 9.75 | 95 | 292069 | 43153 | 79409071 |
Chronic kidney disease | 14.85 | 9.75 | 332 | 291832 | 65822 | 79386402 |
Akathisia | 14.81 | 9.75 | 16 | 292148 | 13243 | 79438981 |
Nodular rash | 14.77 | 9.75 | 11 | 292153 | 310 | 79451914 |
Renal artery angioplasty | 14.71 | 9.75 | 5 | 292159 | 22 | 79452202 |
Renal function test abnormal | 14.68 | 9.75 | 46 | 292118 | 4952 | 79447272 |
Carpal tunnel syndrome | 14.66 | 9.75 | 122 | 292042 | 19406 | 79432818 |
Jaw disorder | 14.64 | 9.75 | 46 | 292118 | 4960 | 79447264 |
Agitation | 14.63 | 9.75 | 267 | 291897 | 99448 | 79352776 |
Shock hypoglycaemic | 14.57 | 9.75 | 10 | 292154 | 247 | 79451977 |
Seizure | 14.56 | 9.75 | 555 | 291609 | 188279 | 79263945 |
Blood osmolarity decreased | 14.54 | 9.75 | 21 | 292143 | 1310 | 79450914 |
Carcinoid tumour of the gastrointestinal tract | 14.43 | 9.75 | 7 | 292157 | 87 | 79452137 |
Lipohypertrophy | 14.43 | 9.75 | 17 | 292147 | 867 | 79451357 |
Blood hyposmosis | 14.36 | 9.75 | 5 | 292159 | 24 | 79452200 |
Cholelithiasis | 14.36 | 9.75 | 272 | 291892 | 52392 | 79399832 |
Depressive symptom | 14.35 | 9.75 | 3 | 292161 | 6420 | 79445804 |
Insomnia | 14.31 | 9.75 | 1063 | 291101 | 244107 | 79208117 |
Trigger finger | 14.30 | 9.75 | 41 | 292123 | 4204 | 79448020 |
Electrocardiogram U-wave abnormality | 14.29 | 9.75 | 7 | 292157 | 89 | 79452135 |
Cardiovascular disorder | 14.28 | 9.75 | 114 | 292050 | 17911 | 79434313 |
Febrile bone marrow aplasia | 14.23 | 9.75 | 16 | 292148 | 13004 | 79439220 |
Alkalosis hypochloraemic | 14.22 | 9.75 | 13 | 292151 | 491 | 79451733 |
Hyponatraemic encephalopathy | 14.21 | 9.75 | 11 | 292153 | 329 | 79451895 |
Gastrointestinal toxicity | 14.11 | 9.75 | 6 | 292158 | 8103 | 79444121 |
Accelerated hypertension | 14.02 | 9.75 | 15 | 292149 | 687 | 79451537 |
Spinal osteoarthritis | 13.93 | 9.75 | 108 | 292056 | 16819 | 79435405 |
Adjustment disorder with depressed mood | 13.88 | 9.75 | 8 | 292156 | 9078 | 79443146 |
Lymphomatoid papulosis | 13.84 | 9.75 | 11 | 292153 | 342 | 79451882 |
Skin exfoliation | 13.82 | 9.75 | 281 | 291883 | 54819 | 79397405 |
Angiopathy | 13.81 | 9.75 | 57 | 292107 | 7025 | 79445199 |
Preternatural anus | 13.69 | 9.75 | 7 | 292157 | 98 | 79452126 |
Vulvovaginal pruritus | 13.69 | 9.75 | 30 | 292134 | 2603 | 79449621 |
Anaphylactic reaction | 13.65 | 9.75 | 220 | 291944 | 83523 | 79368701 |
Device dislocation | 13.63 | 9.75 | 49 | 292115 | 25921 | 79426303 |
Squamous cell carcinoma | 13.60 | 9.75 | 101 | 292063 | 15521 | 79436703 |
Cardiac discomfort | 13.60 | 9.75 | 20 | 292144 | 1268 | 79450956 |
Intervertebral disc displacement | 13.49 | 9.75 | 12 | 292152 | 437 | 79451787 |
Aspiration | 13.48 | 9.75 | 34 | 292130 | 20124 | 79432100 |
Dementia | 13.48 | 9.75 | 144 | 292020 | 24515 | 79427709 |
Blood lactate dehydrogenase increased | 13.48 | 9.75 | 86 | 292078 | 39084 | 79413140 |
Eosinophilia myalgia syndrome | 13.48 | 9.75 | 4 | 292160 | 10 | 79452214 |
Herpes zoster | 13.42 | 9.75 | 250 | 291914 | 92833 | 79359391 |
Recalled product | 13.39 | 9.75 | 17 | 292147 | 937 | 79451287 |
Ventricular arrhythmia | 13.37 | 9.75 | 66 | 292098 | 8774 | 79443450 |
Gastrointestinal angiodysplasia | 13.37 | 9.75 | 18 | 292146 | 1051 | 79451173 |
Laryngeal pain | 13.36 | 9.75 | 51 | 292113 | 6063 | 79446161 |
Hepatitis B reactivation | 13.35 | 9.75 | 3 | 292161 | 6105 | 79446119 |
Eosinophilia | 13.34 | 9.75 | 237 | 291927 | 45108 | 79407116 |
Body temperature decreased | 13.30 | 9.75 | 178 | 291986 | 31967 | 79420257 |
Appendicitis | 13.20 | 9.75 | 36 | 292128 | 20758 | 79431466 |
Plasma cell myeloma | 13.17 | 9.75 | 128 | 292036 | 53131 | 79399093 |
Suicide attempt | 13.15 | 9.75 | 219 | 291945 | 82713 | 79369511 |
Inappropriate schedule of product administration | 13.07 | 9.75 | 381 | 291783 | 133247 | 79318977 |
Lymphangiectasia intestinal | 12.95 | 9.75 | 4 | 292160 | 12 | 79452212 |
Renal artery restenosis | 12.95 | 9.75 | 4 | 292160 | 12 | 79452212 |
Body height decreased | 12.94 | 9.75 | 64 | 292100 | 8516 | 79443708 |
High density lipoprotein decreased | 12.91 | 9.75 | 42 | 292122 | 4613 | 79447611 |
COVID-19 pneumonia | 12.89 | 9.75 | 58 | 292106 | 28791 | 79423433 |
Mouth ulceration | 12.85 | 9.75 | 85 | 292079 | 38309 | 79413915 |
Paraesthesia oral | 12.85 | 9.75 | 123 | 292041 | 20348 | 79431876 |
Bacterial sepsis | 12.84 | 9.75 | 7 | 292157 | 8191 | 79444033 |
Cytomegalovirus test positive | 12.84 | 9.75 | 3 | 292161 | 5944 | 79446280 |
Helicobacter gastritis | 12.84 | 9.75 | 28 | 292136 | 2421 | 79449803 |
Oesophageal carcinoma | 12.80 | 9.75 | 13 | 292151 | 11071 | 79441153 |
International normalised ratio decreased | 12.75 | 9.75 | 61 | 292103 | 8009 | 79444215 |
Rheumatoid factor | 12.73 | 9.75 | 11 | 292153 | 385 | 79451839 |
Exposure to toxic agent | 12.71 | 9.75 | 9 | 292155 | 9149 | 79443075 |
Carotid bruit | 12.68 | 9.75 | 15 | 292149 | 768 | 79451456 |
Haemolysis | 12.68 | 9.75 | 17 | 292147 | 12795 | 79439429 |
Azotaemia | 12.67 | 9.75 | 62 | 292102 | 8214 | 79444010 |
Acute myopia | 12.60 | 9.75 | 7 | 292157 | 117 | 79452107 |
Circumoral oedema | 12.58 | 9.75 | 10 | 292154 | 311 | 79451913 |
Diabetes mellitus | 12.51 | 9.75 | 376 | 291788 | 78014 | 79374210 |
Dysuria | 12.50 | 9.75 | 259 | 291905 | 50692 | 79401532 |
Renin decreased | 12.49 | 9.75 | 7 | 292157 | 119 | 79452105 |
Diabetes mellitus inadequate control | 12.48 | 9.75 | 140 | 292024 | 24124 | 79428100 |
Troponin I increased | 12.47 | 9.75 | 42 | 292122 | 4696 | 79447528 |
Injury | 12.45 | 9.75 | 372 | 291792 | 77124 | 79375100 |
Retroperitoneal fibrosis | 12.44 | 9.75 | 14 | 292150 | 679 | 79451545 |
X-ray abnormal | 12.42 | 9.75 | 3 | 292161 | 5810 | 79446414 |
Peripheral circulatory failure | 12.40 | 9.75 | 18 | 292146 | 1128 | 79451096 |
Small cell carcinoma | 12.39 | 9.75 | 10 | 292154 | 318 | 79451906 |
Incorrect route of product administration | 12.37 | 9.75 | 76 | 292088 | 34853 | 79417371 |
Pneumatosis intestinalis | 12.37 | 9.75 | 4 | 292160 | 6393 | 79445831 |
Neoplasm | 12.36 | 9.75 | 66 | 292098 | 9050 | 79443174 |
Hypoxia | 12.31 | 9.75 | 286 | 291878 | 102957 | 79349267 |
Echocardiogram abnormal | 12.28 | 9.75 | 26 | 292138 | 2202 | 79450022 |
Nephropathy | 12.19 | 9.75 | 69 | 292095 | 9669 | 79442555 |
Asphyxia | 12.17 | 9.75 | 15 | 292149 | 11705 | 79440519 |
Paresis cranial nerve | 12.12 | 9.75 | 5 | 292159 | 41 | 79452183 |
Pathological fracture | 12.11 | 9.75 | 73 | 292091 | 10464 | 79441760 |
Wrong technique in product usage process | 12.07 | 9.75 | 194 | 291970 | 73681 | 79378543 |
Acute hepatic failure | 12.03 | 9.75 | 63 | 292101 | 30050 | 79422174 |
Fibrous histiocytoma | 12.02 | 9.75 | 14 | 292150 | 705 | 79451519 |
Allergic hepatitis | 12.02 | 9.75 | 5 | 292159 | 42 | 79452182 |
Post-anoxic myoclonus | 12.02 | 9.75 | 5 | 292159 | 42 | 79452182 |
Premature labour | 11.97 | 9.75 | 8 | 292156 | 8382 | 79443842 |
Hyperglycaemia | 11.95 | 9.75 | 340 | 291824 | 69995 | 79382229 |
Carcinogenicity | 11.93 | 9.75 | 6 | 292158 | 81 | 79452143 |
Cerebral ischaemia | 11.89 | 9.75 | 76 | 292088 | 11119 | 79441105 |
Coordination abnormal | 11.87 | 9.75 | 106 | 292058 | 17206 | 79435018 |
Haemodialysis | 11.82 | 9.75 | 110 | 292054 | 18058 | 79434166 |
Hemiataxia | 11.81 | 9.75 | 5 | 292159 | 44 | 79452180 |
Metabolic syndrome | 11.80 | 9.75 | 29 | 292135 | 2711 | 79449513 |
Pneumothorax spontaneous | 11.79 | 9.75 | 20 | 292144 | 1434 | 79450790 |
Electrocardiogram Q wave abnormal | 11.78 | 9.75 | 13 | 292151 | 617 | 79451607 |
Renal artery dissection | 11.77 | 9.75 | 3 | 292161 | 3 | 79452221 |
Homans' sign | 11.77 | 9.75 | 3 | 292161 | 3 | 79452221 |
Urinary incontinence | 11.75 | 9.75 | 213 | 291951 | 40696 | 79411528 |
Coronary artery restenosis | 11.74 | 9.75 | 19 | 292145 | 1310 | 79450914 |
Klebsiella infection | 11.73 | 9.75 | 25 | 292139 | 15695 | 79436529 |
CD4/CD8 ratio increased | 11.70 | 9.75 | 4 | 292160 | 18 | 79452206 |
Hypocalcaemia | 11.67 | 9.75 | 252 | 291912 | 49672 | 79402552 |
Vestibular neuronitis | 11.65 | 9.75 | 14 | 292150 | 729 | 79451495 |
Cyanopsia | 11.61 | 9.75 | 6 | 292158 | 86 | 79452138 |
Coronary artery stenosis | 11.61 | 9.75 | 82 | 292082 | 12402 | 79439822 |
Non-cardiac chest pain | 11.61 | 9.75 | 67 | 292097 | 9457 | 79442767 |
Intervertebral disc protrusion | 11.57 | 9.75 | 135 | 292029 | 23486 | 79428738 |
Electrocardiogram T wave amplitude decreased | 11.54 | 9.75 | 14 | 292150 | 736 | 79451488 |
Pulmonary alveolar haemorrhage | 11.54 | 9.75 | 15 | 292149 | 11442 | 79440782 |
Cardiac arrest | 11.52 | 9.75 | 514 | 291650 | 171582 | 79280642 |
Osteitis deformans | 11.50 | 9.75 | 8 | 292156 | 202 | 79452022 |
Hepatojugular reflux | 11.48 | 9.75 | 13 | 292151 | 635 | 79451589 |
Renal artery arteriosclerosis | 11.44 | 9.75 | 5 | 292159 | 48 | 79452176 |
Nail bed inflammation | 11.43 | 9.75 | 12 | 292152 | 538 | 79451686 |
Drug use disorder | 11.37 | 9.75 | 9 | 292155 | 8642 | 79443582 |
Staphylococcal sepsis | 11.34 | 9.75 | 23 | 292141 | 14703 | 79437521 |
Electrocardiogram Q waves | 11.31 | 9.75 | 6 | 292158 | 91 | 79452133 |
Device use error | 11.22 | 9.75 | 6 | 292158 | 7095 | 79445129 |
Vitamin B1 decreased | 11.19 | 9.75 | 12 | 292152 | 551 | 79451673 |
Haemorrhagic stroke | 11.13 | 9.75 | 74 | 292090 | 10972 | 79441252 |
Dysarthria | 10.97 | 9.75 | 325 | 291839 | 67297 | 79384927 |
Atrophy | 10.89 | 9.75 | 24 | 292140 | 2090 | 79450134 |
Inflammatory marker increased | 10.88 | 9.75 | 14 | 292150 | 10726 | 79441498 |
Neuroglycopenia | 10.85 | 9.75 | 11 | 292153 | 473 | 79451751 |
Gastrointestinal mucosal necrosis | 10.85 | 9.75 | 8 | 292156 | 222 | 79452002 |
Hepatotoxicity | 10.85 | 9.75 | 128 | 292036 | 51224 | 79401000 |
Back pain | 10.82 | 9.75 | 1273 | 290891 | 302907 | 79149317 |
Hypervitaminosis D | 10.81 | 9.75 | 6 | 292158 | 100 | 79452124 |
Nodal arrhythmia | 10.81 | 9.75 | 23 | 292141 | 1955 | 79450269 |
Ischaemic stroke | 10.78 | 9.75 | 176 | 291988 | 32955 | 79419269 |
Diverticulum oesophageal | 10.75 | 9.75 | 7 | 292157 | 158 | 79452066 |
Type V hyperlipidaemia | 10.73 | 9.75 | 16 | 292148 | 1027 | 79451197 |
Radiculopathy | 10.70 | 9.75 | 62 | 292102 | 8762 | 79443462 |
Abdominal tenderness | 10.69 | 9.75 | 71 | 292093 | 10523 | 79441701 |
Hepatocellular injury | 10.69 | 9.75 | 117 | 292047 | 47476 | 79404748 |
Thirst decreased | 10.69 | 9.75 | 9 | 292155 | 304 | 79451920 |
Adiposis dolorosa | 10.69 | 9.75 | 9 | 292155 | 304 | 79451920 |
Swelling face | 10.68 | 9.75 | 339 | 291825 | 70873 | 79381351 |
Cachexia | 10.67 | 9.75 | 15 | 292149 | 11068 | 79441156 |
Aortic stenosis | 10.67 | 9.75 | 55 | 292109 | 7440 | 79444784 |
Onychomadesis | 10.64 | 9.75 | 3 | 292161 | 5239 | 79446985 |
Hypersensitivity vasculitis | 10.62 | 9.75 | 52 | 292112 | 6891 | 79445333 |
Supraventricular tachycardia | 10.62 | 9.75 | 122 | 292042 | 21148 | 79431076 |
Confabulation | 10.59 | 9.75 | 11 | 292153 | 487 | 79451737 |
Cardiac stress test abnormal | 10.58 | 9.75 | 14 | 292150 | 804 | 79451420 |
Depressed mood | 10.57 | 9.75 | 120 | 292044 | 48360 | 79403864 |
Pulmonary tuberculosis | 10.56 | 9.75 | 8 | 292156 | 7857 | 79444367 |
Diabetic neuropathy | 10.56 | 9.75 | 48 | 292116 | 6168 | 79446056 |
Pulpitis dental | 10.56 | 9.75 | 18 | 292146 | 1295 | 79450929 |
Colitis | 10.53 | 9.75 | 197 | 291967 | 73110 | 79379114 |
Device occlusion | 10.51 | 9.75 | 17 | 292147 | 11849 | 79440375 |
Peripheral venous disease | 10.51 | 9.75 | 27 | 292137 | 15882 | 79436342 |
Aplasia | 10.45 | 9.75 | 8 | 292156 | 7812 | 79444412 |
Forced vital capacity decreased | 10.39 | 9.75 | 21 | 292143 | 1722 | 79450502 |
Staring | 10.36 | 9.75 | 27 | 292137 | 2618 | 79449606 |
Pseudolymphoma | 10.34 | 9.75 | 17 | 292147 | 1188 | 79451036 |
Electrocardiogram ST-T change | 10.33 | 9.75 | 20 | 292144 | 1589 | 79450635 |
Parotitis | 10.33 | 9.75 | 26 | 292138 | 2468 | 79449756 |
Endometrial disorder | 10.29 | 9.75 | 12 | 292152 | 605 | 79451619 |
Carotid arteriosclerosis | 10.29 | 9.75 | 27 | 292137 | 2629 | 79449595 |
Neuroleptic malignant syndrome | 10.27 | 9.75 | 59 | 292105 | 27500 | 79424724 |
Shock | 10.24 | 9.75 | 220 | 291944 | 43328 | 79408896 |
Renal arteriosclerosis | 10.23 | 9.75 | 9 | 292155 | 323 | 79451901 |
Parainfluenzae virus infection | 10.22 | 9.75 | 4 | 292160 | 5678 | 79446546 |
Product commingling | 10.21 | 9.75 | 6 | 292158 | 112 | 79452112 |
Spinal cord infarction | 10.20 | 9.75 | 12 | 292152 | 611 | 79451613 |
Oesophageal discomfort | 10.18 | 9.75 | 9 | 292155 | 325 | 79451899 |
Bladder irrigation | 10.18 | 9.75 | 5 | 292159 | 64 | 79452160 |
Transaminases increased | 10.17 | 9.75 | 131 | 292033 | 51612 | 79400612 |
Sleep apnoea syndrome | 10.15 | 9.75 | 189 | 291975 | 36289 | 79415935 |
Blood growth hormone increased | 10.15 | 9.75 | 13 | 292151 | 723 | 79451501 |
Hypoparathyroidism | 10.11 | 9.75 | 16 | 292148 | 1082 | 79451142 |
Aortic valve sclerosis | 10.08 | 9.75 | 21 | 292143 | 1759 | 79450465 |
QRS axis abnormal | 10.07 | 9.75 | 23 | 292141 | 2051 | 79450173 |
Encephalopathy | 10.03 | 9.75 | 180 | 291984 | 67217 | 79385007 |
Glomerulonephritis rapidly progressive | 9.99 | 9.75 | 20 | 292144 | 1628 | 79450596 |
Gastrointestinal perforation | 9.97 | 9.75 | 5 | 292159 | 6132 | 79446092 |
Haemarthrosis | 9.97 | 9.75 | 45 | 292119 | 5767 | 79446457 |
Immunosuppressant drug level increased | 9.97 | 9.75 | 11 | 292153 | 9016 | 79443208 |
Ischaemic cardiomyopathy | 9.95 | 9.75 | 55 | 292109 | 7640 | 79444584 |
Macrocytosis | 9.94 | 9.75 | 28 | 292136 | 2842 | 79449382 |
Mitral valve disease | 9.93 | 9.75 | 30 | 292134 | 3167 | 79449057 |
Product residue present | 9.89 | 9.75 | 32 | 292132 | 3504 | 79448720 |
Haemorrhagic fever | 9.89 | 9.75 | 4 | 292160 | 31 | 79452193 |
Immunosuppression | 9.86 | 9.75 | 20 | 292144 | 12783 | 79439441 |
Pneumothorax | 9.84 | 9.75 | 62 | 292102 | 28261 | 79423963 |
Product administered to patient of inappropriate age | 9.84 | 9.75 | 4 | 292160 | 5549 | 79446675 |
Night sweats | 9.83 | 9.75 | 133 | 292031 | 51962 | 79400262 |
Encephalitis | 9.79 | 9.75 | 25 | 292139 | 14735 | 79437489 |
Activated partial thromboplastin time | 9.78 | 9.75 | 4 | 292160 | 32 | 79452192 |
Coronary arterial stent insertion | 9.78 | 9.75 | 46 | 292118 | 5998 | 79446226 |
Wound treatment | 9.76 | 9.75 | 7 | 292157 | 186 | 79452038 |
Normal newborn | 9.75 | 9.75 | 7 | 292157 | 7065 | 79445159 |
None
Source | Code | Description |
---|---|---|
ATC | C03AA03 | CARDIOVASCULAR SYSTEM DIURETICS LOW-CEILING DIURETICS, THIAZIDES Thiazides, plain |
ATC | C03AB03 | CARDIOVASCULAR SYSTEM DIURETICS LOW-CEILING DIURETICS, THIAZIDES Thiazides and potassium in combination |
ATC | C03AX01 | CARDIOVASCULAR SYSTEM DIURETICS LOW-CEILING DIURETICS, THIAZIDES Thiazides, combinations with other drugs |
ATC | C03EA01 | CARDIOVASCULAR SYSTEM DIURETICS DIURETICS AND POTASSIUM-SPARING AGENTS IN COMBINATION Low-ceiling diuretics and potassium-sparing agents |
ATC | C09BX03 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors, other combinations |
ATC | C09DX01 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs), other combinations |
ATC | C09DX03 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs), other combinations |
ATC | C09DX06 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs), other combinations |
ATC | C09DX07 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs), other combinations |
ATC | C09DX08 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs), other combinations |
ATC | C09XA52 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM OTHER AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM Renin-inhibitors |
ATC | C09XA54 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM OTHER AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM Renin-inhibitors |
FDA CS | M0471776 | Thiazides |
FDA PE | N0000175359 | Increased Diuresis |
FDA EPC | N0000175419 | Thiazide Diuretic |
MeSH PA | D000959 | Antihypertensive Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D004232 | Diuretics |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D045283 | Natriuretic Agents |
MeSH PA | D049993 | Sodium Chloride Symporter Inhibitors |
CHEBI has role | CHEBI:35498 | diuretics |
CHEBI has role | CHEBI:35674 | antihypertensive drugs |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:78298 | environmental contaminants |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Hypertensive disorder | indication | 38341003 | DOID:10763 |
Chronic heart failure | indication | 48447003 | |
Edema | indication | 267038008 | |
Hypertensive urgency | indication | 443482000 | |
Pulmonary Edema due to Chronic Heart Failure | indication | ||
Peripheral Edema due to Chronic Heart Failure | indication | ||
Edema due to Hepatic Cirrhosis | indication | ||
Hypertension with Left Ventricular Hypertrophy | indication | ||
Edema due to Nephrotic Syndrome | indication | ||
Nephrogenic diabetes insipidus | off-label use | 111395007 | DOID:12387 |
Calcium renal calculus | off-label use | 427649000 | |
Anuria | contraindication | 2472002 | DOID:2983 |
Bronchospasm | contraindication | 4386001 | |
Suicidal thoughts | contraindication | 6471006 | |
Psoriasis | contraindication | 9014002 | DOID:8893 |
Peptic ulcer | contraindication | 13200003 | DOID:750 |
Hypercholesterolemia | contraindication | 13644009 | |
Hyperkalemia | contraindication | 14140009 | |
Chronic disease of respiratory system | contraindication | 17097001 | |
Metabolic acidosis, normal anion gap, acidifying salts | contraindication | 18104000 | |
Jaundice | contraindication | 18165001 | |
Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
Secondary angle-closure glaucoma | contraindication | 21571006 | |
Electroconvulsive therapy | contraindication | 23835007 | |
Acute vomiting | contraindication | 23971007 | |
Complete atrioventricular block | contraindication | 27885002 | |
Hypovolemia | contraindication | 28560003 | |
Acute cerebrovascular insufficiency | contraindication | 29322000 | |
Obstruction of bile duct | contraindication | 30144000 | |
Parkinsonism | contraindication | 32798002 | |
Dehydration | contraindication | 34095006 | |
Depressive disorder | contraindication | 35489007 | |
Hyperuricemia | contraindication | 35885006 | DOID:1920 |
Sick sinus syndrome | contraindication | 36083008 | DOID:13884 |
Acute hepatitis | contraindication | 37871000 | |
Immunosuppression | contraindication | 38013005 | |
Anaphylaxis | contraindication | 39579001 | |
Angioedema | contraindication | 41291007 | DOID:1558 |
Hypokalemia | contraindication | 43339004 | |
Diabetes mellitus type 2 | contraindication | 44054006 | DOID:9352 |
Conduction disorder of the heart | contraindication | 44808001 | |
Low blood pressure | contraindication | 45007003 | |
Diabetes mellitus type 1 | contraindication | 46635009 | DOID:9744 |
Sinus bradycardia | contraindication | 49710005 | |
Cough | contraindication | 49727002 | |
Acidosis | contraindication | 51387008 | |
Syndrome of inappropriate vasopressin secretion | contraindication | 55004003 | DOID:3401 |
Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
Sympathectomy | contraindication | 57071006 | |
Acute nephropathy | contraindication | 58574008 | |
Hepatic failure | contraindication | 59927004 | |
Aortic valve stenosis | contraindication | 60573004 | DOID:1712 |
Chronic bronchitis | contraindication | 63480004 | DOID:6132 |
Ulcerative colitis | contraindication | 64766004 | DOID:8577 |
Hypercalcemia | contraindication | 66931009 | DOID:12678 |
Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
Benign intracranial hypertension | contraindication | 68267002 | DOID:11459 |
Hypochloremic alkalosis | contraindication | 70134007 | |
Hepatic coma | contraindication | 72836002 | DOID:12550 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Wolff-Parkinson-White pattern | contraindication | 74390002 | DOID:384 |
Transplantation | contraindication | 77465005 | |
Chronic idiopathic constipation | contraindication | 82934008 | |
Hereditary angioneurotic edema | contraindication | 82966003 | DOID:14735 |
Oliguria | contraindication | 83128009 | |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Megaloblastic anemia due to folate deficiency | contraindication | 85649008 | DOID:14026 |
Pulmonary emphysema | contraindication | 87433001 | |
Cardiogenic shock | contraindication | 89138009 | |
Hyponatremia | contraindication | 89627008 | |
Gout | contraindication | 90560007 | DOID:13189 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Kidney stone | contraindication | 95570007 | |
Disorder of connective tissue | contraindication | 105969002 | DOID:65 |
Diabetic renal disease | contraindication | 127013003 | |
Disorder of muscle | contraindication | 129565002 | DOID:423 |
Liver function tests abnormal | contraindication | 166603001 | |
Hypomagnesemia | contraindication | 190855004 | |
Angina pectoris | contraindication | 194828000 | |
Partial atrioventricular block | contraindication | 195039008 | |
Second degree atrioventricular block | contraindication | 195042002 | |
Decompensated cardiac failure | contraindication | 195111005 | |
Asthma | contraindication | 195967001 | DOID:2841 |
Acute hepatic failure | contraindication | 197270009 | |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Impaired renal function disorder | contraindication | 197663003 | |
Cerebrovascular accident | contraindication | 230690007 | |
Hypertrophic cardiomyopathy | contraindication | 233873004 | DOID:11984 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Hypoglycemic disorder | contraindication | 237630007 | |
Disorder of electrolytes | contraindication | 237840007 | |
Lupus erythematosus and erythema multiforme-like syndrome | contraindication | 238926009 | |
Rhabdomyolysis | contraindication | 240131006 | |
Raynaud's phenomenon | contraindication | 266261006 | |
Calculus in biliary tract | contraindication | 266474003 | |
Anemia | contraindication | 271737000 | DOID:2355 |
Neonatal hyperbilirubinemia | contraindication | 281610001 | |
Pregnancy, function | contraindication | 289908002 | |
Renal artery stenosis | contraindication | 302233006 | |
Pheochromocytoma | contraindication | 302835009 | |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Bone marrow depression | contraindication | 307762000 | |
Severe chronic obstructive pulmonary disease | contraindication | 313299006 | |
Right ventricular failure | contraindication | 367363000 | |
Surgical procedure | contraindication | 387713003 | |
Peripheral arterial occlusive disease | contraindication | 399957001 | |
Peripheral vascular disease | contraindication | 400047006 | |
Severe diarrhea | contraindication | 409587002 | |
Autoimmune hemolytic anemia | contraindication | 413603009 | DOID:718 |
Disorder of coronary artery | contraindication | 414024009 | |
Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
Myocardial infarction in recovery phase | contraindication | 418044006 | |
Porphyria | contraindication | 418470004 | |
Intraoperative floppy iris syndrome | contraindication | 418801006 | |
Poor metabolizer due to cytochrome p450 CYP2D6 variant | contraindication | 423629005 | |
Slow acetylator due to N-acetyltransferase enzyme variant | contraindication | 425079005 | |
Azotemia | contraindication | 445009001 | |
Smokes tobacco daily | contraindication | 449868002 | |
Acute exacerbation of asthma | contraindication | 708038006 | |
First Degree Atrioventricular Heart Block | contraindication | ||
Intestinal Angioedema | contraindication | ||
Severe Aortic Valve Stenosis | contraindication | ||
Hemodialysis with High-Flux Membrane | contraindication | ||
Head and Neck Angioedema | contraindication | ||
Severe Cerebrovascular Disease | contraindication |
Species | Use | Relation |
---|---|---|
Cattle | Postparturient udder edema | Indication |
Product | Applicant | Ingredients |
---|---|---|
Hydrozide Injection | Boehringer lngelheim Animal Health USA Inc. | 1 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.89 | acidic |
pKa2 | 11.02 | acidic |
pKa3 | 0.71 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Solute carrier family 12 member 3 | Transporter | INHIBITOR | A2 | 7.01 | WOMBAT-PK | CHEMBL | |||
Carbonic anhydrase 1 | Enzyme | Ki | 6.48 | CHEMBL | |||||
Carbonic anhydrase 4 | Enzyme | WOMBAT-PK | |||||||
Calcium-activated potassium channel subunit alpha-1 | Ion channel | WOMBAT-PK | |||||||
Carbonic anhydrase 2 | Enzyme | Ki | 5.90 | WOMBAT-PK | |||||
Astrosclerin-3 | Enzyme | Ki | 6.40 | CHEMBL | |||||
Delta carbonic anhydrase | Unclassified | Ki | 5.37 | CHEMBL | |||||
Carbonic anhydrase | Enzyme | Ki | 7.50 | CHEMBL | |||||
Carbonic anhydrase, alpha family | Unclassified | Ki | 6.53 | CHEMBL | |||||
Carbonate dehydratase | Enzyme | Ki | 8.14 | CHEMBL |
ID | Source |
---|---|
4017615 | VUID |
N0000145995 | NUI |
D00340 | KEGG_DRUG |
4017615 | VANDF |
C0020261 | UMLSCUI |
CHEBI:5778 | CHEBI |
HCZ | PDB_CHEM_ID |
CHEMBL435 | ChEMBL_ID |
CHEMBL43686 | ChEMBL_ID |
CHEMBL15605 | ChEMBL_ID |
DB00999 | DRUGBANK_ID |
D006852 | MESH_DESCRIPTOR_UI |
3639 | PUBCHEM_CID |
4836 | IUPHAR_LIGAND_ID |
841 | INN_ID |
0J48LPH2TH | UNII |
5487 | RXNORM |
4834 | MMSL |
924 | MMSL |
d00253 | MMSL |
002294 | NDDF |
387525002 | SNOMEDCT_US |
91667005 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Avalide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0024-5855 | TABLET, FILM COATED | 12.50 mg | ORAL | NDA | 30 sections |
Avalide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0024-5855 | TABLET, FILM COATED | 12.50 mg | ORAL | NDA | 30 sections |
Avalide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0024-5856 | TABLET, FILM COATED | 12.50 mg | ORAL | NDA | 30 sections |
Avalide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0024-5856 | TABLET, FILM COATED | 12.50 mg | ORAL | NDA | 30 sections |
ALDACTAZIDE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0025-1011 | TABLET, FILM COATED | 25 mg | ORAL | NDA | 24 sections |
ALDACTAZIDE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0025-1011 | TABLET, FILM COATED | 25 mg | ORAL | NDA | 24 sections |
ALDACTAZIDE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0025-1021 | TABLET, FILM COATED | 50 mg | ORAL | NDA | 24 sections |
ALDACTAZIDE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0025-1021 | TABLET, FILM COATED | 50 mg | ORAL | NDA | 24 sections |
Irbesartan and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0054-0254 | TABLET | 12.50 mg | ORAL | ANDA | 28 sections |
Irbesartan and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0054-0255 | TABLET | 12.50 mg | ORAL | ANDA | 28 sections |
telmisartan and hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0054-0545 | TABLET | 12.50 mg | ORAL | NDA authorized generic | 27 sections |
telmisartan and hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0054-0546 | TABLET | 12.50 mg | ORAL | NDA authorized generic | 27 sections |
telmisartan and hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0054-0547 | TABLET | 25 mg | ORAL | NDA authorized generic | 27 sections |
ACCURETIC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0071-0220 | TABLET, FILM COATED | 12.50 mg | ORAL | NDA | 22 sections |
ACCURETIC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0071-0222 | TABLET, FILM COATED | 12.50 mg | ORAL | NDA | 22 sections |
ACCURETIC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0071-0223 | TABLET, FILM COATED | 25 mg | ORAL | NDA | 22 sections |
ACCURETIC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0071-0223 | TABLET, FILM COATED | 25 mg | ORAL | NDA | 22 sections |
ACCURETIC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0071-3112 | TABLET, FILM COATED | 12.50 mg | ORAL | NDA | 22 sections |
ACCURETIC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0071-3112 | TABLET, FILM COATED | 12.50 mg | ORAL | NDA | 22 sections |
ACCURETIC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0071-5212 | TABLET, FILM COATED | 12.50 mg | ORAL | NDA | 22 sections |
ACCURETIC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0071-5212 | TABLET, FILM COATED | 12.50 mg | ORAL | NDA | 22 sections |
ACCURETIC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0071-7225 | TABLET, FILM COATED | 25 mg | ORAL | NDA | 22 sections |
ACCURETIC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0071-7225 | TABLET, FILM COATED | 25 mg | ORAL | NDA | 22 sections |
Diovan HCT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0314 | TABLET, FILM COATED | 12.50 mg | ORAL | NDA | 31 sections |
Diovan HCT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0314 | TABLET, FILM COATED | 12.50 mg | ORAL | NDA | 31 sections |
Diovan HCT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0314 | TABLET, FILM COATED | 12.50 mg | ORAL | NDA | 31 sections |
Diovan HCT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0315 | TABLET, FILM COATED | 12.50 mg | ORAL | NDA | 31 sections |
Diovan HCT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0315 | TABLET, FILM COATED | 12.50 mg | ORAL | NDA | 31 sections |
Diovan HCT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0315 | TABLET, FILM COATED | 12.50 mg | ORAL | NDA | 31 sections |
Diovan HCT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0383 | TABLET, FILM COATED | 25 mg | ORAL | NDA | 31 sections |