homatropine

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Property	Description	Value	Unit	Confidence	Similarity
azlogd74	LogD at pH 7.4	-0.269		Moderate	0.71
caco2-efflux	Caco-2 efflux ratio (BA/AB)	2.679		Moderate	0.71
caco2-intrinsic-papp	Caco-2 intrinsic apparent permeability	3.855	10^-6 cm/s	Moderate	0.71
dh-clint	Dog hepatocyte intrinsic clearance	12.794	uL/min/10^6 cells	Moderate	0.71
dppb	Dog plasma protein binding (% unbound)	83.900	%	Moderate	0.71
fcs-ppb	Fetal calf serum protein binding (% unbound)	72.910	%	Moderate	0.71
herg	hERG pIC50	4.390	pIC50	Moderate	0.71
hh-clint	Human hepatocyte intrinsic clearance	3.715	uL/min/10^6 cells	Moderate	0.71
hlm-clint	Human liver microsomal intrinsic clearance	5.012	uL/min/mg protein	Moderate	0.71
hppb	Human plasma protein binding (% unbound)	81.080	%	Moderate	0.71
kinase-safety-class	ACVR2A,ACVR2B,AKT2,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK3,MAP3K21,MAP3K7,MAPK7,MAPKAPK2,MET,NTRK2,PDK2,PDK4,PIM2,PRKDC,SIK2,SIK3,STK33,TEK,TGFBR1	35
kinase-selectivity-class	AXL,CAMK2D,CDK4,EIF2AK3,PDK4	5
mdck-mdr1-bcrp-efflux	MDCK-MDR1-BCRP efflux ratio	1.361		Moderate	0.71
mdck-mdr1-efflux	MDCK-MDR1 efflux ratio	2.089		Moderate	0.71
mh-clint	Mouse hepatocyte intrinsic clearance	137.721		Moderate	0.71
mppb	Mouse plasma protein binding (% unbound)	87.240		Moderate	0.71
nih-mdck-mdr1-efflux	NIH MDCK-MDR1 efflux ratio	4.406		Moderate	0.71
pfas-class	PFAS structural alert (1 = True, 0 = False)	0
pld-class	Phospholipidosis risk class (1 = positive, 0 = negative)	0		Moderate	0.71
pppb	Pig plasma protein binding (% unbound)	86.050	%	Moderate	0.71
rat-kpuu-brain	Rat brain Kpuu	0.102	%	Moderate	0.71
rh-clint	Rat hepatocyte intrinsic clearance	59.841	uL/min/10^6 cells	Moderate	0.71
rh-fuinc	Rat hepatocyte fraction unbound in incubation	91.170	%	Moderate	0.71
rppb	Rat plasma protein binding (% unbound)	76.810	%	Moderate	0.71
solubility-dd	Solubility at pH 7.4 in DMSO	716.143	uM	Moderate	0.71

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Endophthalmitis	523.69	359.59	79	480	8108	110580632
Choroiditis	432.66	359.59	55	504	1560	110587180

Source	Code	Description
ATC	S01FA05	SENSORY ORGANS OPHTHALMOLOGICALS MYDRIATICS AND CYCLOPLEGICS Anticholinergics
FDA MoA	N0000000125	Cholinergic Muscarinic Antagonists
MeSH PA	D010276	Parasympatholytics
MeSH PA	D018373	Peripheral Nervous System Agents
FDA EPC	N0000175700	Cholinergic Muscarinic Antagonist

Disease	Relation	SNOMED_ID	DOID
Irritable bowel syndrome	indication	10743008	DOID:9778
Peptic ulcer	indication	13200003	DOID:750
Constipation	indication	14760008	DOID:2089
Cough	indication	49727002
Cycloplegia	indication	68158006	DOID:10033
Disorder of biliary tract	indication	105997008	DOID:9741
Uveitis	indication	128473001	DOID:13141
Incomplete passage of stool	indication	249515001
Perioperative Mydriasis	indication
Brain damage	contraindication	2470005
Tachyarrhythmia	contraindication	6285003
Suicidal thoughts	contraindication	6471006
Dependent drug abuse	contraindication	6525002
Urinary tract obstruction	contraindication	7163005	DOID:5200
Alcoholism	contraindication	7200002
Alcohol withdrawal delirium	contraindication	8635005
Hyperammonemia	contraindication	9360008
Asthenia	contraindication	13791008
Hepatic encephalopathy	contraindication	13920009	DOID:13413
Severe chronic ulcerative colitis	contraindication	14311001
Mood swings	contraindication	18963009
Inflammatory bowel disease	contraindication	24526004	DOID:0050589
Alcohol intoxication	contraindication	25702006
Shock	contraindication	27942005
Toxic megacolon	contraindication	28536002	DOID:1770
Atony of colon	contraindication	29479008
Hypercapnia	contraindication	29596007
Dehydration	contraindication	34095006
Hyperthyroidism	contraindication	34486009	DOID:7998
Depressive disorder	contraindication	35489007
Hypertensive disorder	contraindication	38341003	DOID:10763
Disorder of gallbladder	contraindication	39621005	DOID:0060262
Hypothyroidism	contraindication	40930008	DOID:1459
Complete trisomy 21 syndrome	contraindication	41040004	DOID:14250
Conduction disorder of the heart	contraindication	44808001
Low blood pressure	contraindication	45007003
Achalasia of esophagus	contraindication	45564002	DOID:9164
Chronic heart failure	contraindication	48447003
Bradycardia	contraindication	48867003
Paralytic ileus	contraindication	55525008	DOID:8442
Peptic reflux disease	contraindication	57643001
Hepatic failure	contraindication	59927004
Ulcerative colitis	contraindication	64766004	DOID:8577
Poisoning by phenobarbital	contraindication	64921004
Drug AND/OR toxin-induced diarrhea	contraindication	65979008
Substance abuse	contraindication	66214007
Benign intracranial hypertension	contraindication	68267002	DOID:11459
Incontinence of feces	contraindication	72042002
Hepatic coma	contraindication	72836002	DOID:12550
Sleep apnea	contraindication	73430006	DOID:0050847
Appendicitis	contraindication	74400008	DOID:8337
Urethral stricture	contraindication	76618002
Spastic paralysis	contraindication	78403003
Disturbance of salivary secretion	contraindication	78948009
Decreased respiratory function	contraindication	80954004
Injury of head	contraindication	82271004
Cor pulmonale	contraindication	83291003	DOID:8515
Hiatal hernia	contraindication	84089009	DOID:12642
Pulmonary emphysema	contraindication	87433001
Kidney disease	contraindication	90708001	DOID:557
Myasthenia gravis	contraindication	91637004	DOID:437
Acute abdominal pain	contraindication	116290004
Gastrointestinal obstruction	contraindication	126765001
Neoplasm of brain	contraindication	126952004	DOID:1319
Seizure disorder	contraindication	128613002
Autonomic dysreflexia	contraindication	129618003
Bleeding	contraindication	131148009
Drug-induced psychosis	contraindication	191483003	DOID:1742
Myocardial dysfunction	contraindication	233928007
Disease of liver	contraindication	235856003	DOID:409
Bladder outflow obstruction	contraindication	236645006
Morbid obesity	contraindication	238136002	DOID:11981
Pyloric obstruction	contraindication	244815007
Shallow anterior chamber of eye	contraindication	246986004
Benign prostatic hyperplasia	contraindication	266569009
Dyspnea	contraindication	267036007
Retention of urine	contraindication	267064002
Anemia	contraindication	271737000	DOID:2355
Drowsy	contraindication	271782001
Exacerbation of asthma	contraindication	281239006
Pregnancy, function	contraindication	289908002
Lesion of brain	contraindication	301766008
Thrombocytopenic disorder	contraindication	302215000	DOID:1588
Neutropenic disorder	contraindication	303011007	DOID:1227
Coma	contraindication	371632003
Primary adrenocortical insufficiency	contraindication	373662000
Operation on gastrointestinal tract	contraindication	386621005
Hypoxia	contraindication	389086002
Angle-closure glaucoma	contraindication	392291006	DOID:13550
Gastric ulcer	contraindication	397825006	DOID:10808
Breastfeeding (mother)	contraindication	413712001
Chronic lung disease	contraindication	413839001
Disorder of coronary artery	contraindication	414024009
Central nervous system depression	contraindication	418072004
Porphyria	contraindication	418470004
Dysfunction of sphincter of Oddi	contraindication	430887001
Predisposition to Glaucoma	contraindication
Primary Closed Angle Glaucoma	contraindication

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	13.82	acidic
pKa2	9.26	Basic

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homatropine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Description:

Drug dosage:

ADMET properties:

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Approvals:

FDA Adverse Event Reporting System (Female)

FDA Adverse Event Reporting System (Male)

FDA Adverse Event Reporting System (Geriatric)

FDA Adverse Event Reporting System (Pediatric)

Pharmacologic Action:

Related Drugs by ATC class:

Drug Use | Suggest Off label Use Form| |View source of the data|

🐶 Veterinary Drug Use

🐶 Veterinary products

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

Orange Book exclusivity data (new drug applications)

Bioactivity Summary:

External reference:

Pharmaceutical products:

Target	Class	Pharos	UniProt	Type	Activity value (-log[M])	Bioact source
Muscarinic acetylcholine receptor M1	GPCR	P11229	ACM1_HUMAN	Ki	7.50	DRUG MATRIX
Muscarinic acetylcholine receptor M2	GPCR	P08172	ACM2_HUMAN	Ki	7.13	DRUG MATRIX
Muscarinic acetylcholine receptor M3	GPCR	P20309	ACM3_HUMAN	Ki	7.80	DRUG MATRIX
Muscarinic acetylcholine receptor M4	GPCR	P08173	ACM4_HUMAN	Ki	7.85	DRUG MATRIX
Muscarinic acetylcholine receptor M5	GPCR	P08912	ACM5_HUMAN	Ki	7.41	DRUG MATRIX

ID	Source
4019777	VUID
N0000171598	NUI
D01004	KEGG_DRUG
4018591	VANDF
4019777	VANDF
C0062922	UMLSCUI
CHEBI:5747	CHEBI
CHEMBL1618018	ChEMBL_ID
DB11181	DRUGBANK_ID
CHEMBL1319362	ChEMBL_ID
C100236	MESH_SUPPLEMENTAL_RECORD_UI
5282593	PUBCHEM_CID
51-56-9	SECONDARY_CAS_RN
8QS6WCL55Z	UNII
235428	RXNORM
4830	MMSL
7916	MMSL
816	MMSL
d04149	MMSL
001723	NDDF
001724	NDDF
126132001	SNOMEDCT_US
372864009	SNOMEDCT_US
82264009	SNOMEDCT_US