DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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Structure 🔎
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
Scroll
All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
histidine 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
1377
71-00-1
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
L-Histidine
histidine
An essential amino acid that is required for the production of HISTAMINE.
Molecular weight: 155.16
Formula: C6H9N3O2
CLOGP: -3.73
LIPINSKI: 0
HAC: 5
HDO: 3
TPSA: 92
ALOGS: -0.40
ROTB: 3
Drug dosage:
None
ADMET properties:
None
Approvals:
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Date
Agency
Company
Orphan
None
FDA
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FDA Adverse Event Reporting System (Female)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Foetal growth restriction
93.79
87.08
15
82
7538
63481387
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FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
CHEBI has role
CHEBI:27027
trace elements
CHEBI has role
CHEBI:50733
Dietary Supplement
CHEBI has role
CHEBI:75771
Mus musculus metabolites
CHEBI has role
CHEBI:75772
S. cerevisiae metabolites
CHEBI has role
CHEBI:76971
Escherichia coli metabolites
CHEBI has role
CHEBI:77746
Homo sapiens metabolite
CHEBI has role
CHEBI:84735
algal metabolites
CHEBI has role
CHEBI:25212
metabolites
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Classical phenylketonuria
contraindication
7573000
Poisoning by digitalis glycoside
contraindication
12876009
Hypocupremia
contraindication
19577007
Sarcoidosis
contraindication
31541009
DOID:11335
End stage renal disease
contraindication
46177005
DOID:784
Humoral hypercalcemia of malignancy
contraindication
47709007
Heart disease
contraindication
56265001
DOID:114
Hypercalcemia
contraindication
66931009
DOID:12678
Ventricular fibrillation
contraindication
71908006
Hypercalciuria
contraindication
71938000
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
1.48
acidic
pKa2
13.85
acidic
pKa3
9.28
Basic
pKa4
6.6
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Large neutral amino acids transporter small subunit 1
Transporter
Q01650
LAT1_HUMAN
IC50
4.70
CHEMBL
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External reference:
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entries
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ID
Source
HIS
PDB_CHEM_ID
004535
NDDF
3310
IUPHAR_LIGAND_ID
4018669
VUID
4018669
VANDF
4QD397987E
UNII
5340
RXNORM
60260004
SNOMEDCT_US
6163
INN_ID
6274
PUBCHEM_CID
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Pharmaceutical products:
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Product
Category
Ingredients
NDC
Form
Quantity
Route
Marketing
Label
CLINIMIX
HUMAN PRESCRIPTION DRUG LABEL
16
0338-0180
INJECTION
384 mg
INTRAVENOUS
NDA
21 sections
CLINIMIX
HUMAN PRESCRIPTION DRUG LABEL
16
0338-0180
INJECTION
384 mg
INTRAVENOUS
NDA
21 sections
CLINIMIX
HUMAN PRESCRIPTION DRUG LABEL
16
0338-0184
INJECTION, EMULSION
384 mg
INTRAVENOUS
NDA
21 sections
CLINIMIX
HUMAN PRESCRIPTION DRUG LABEL
16
0338-0184
INJECTION, EMULSION
384 mg
INTRAVENOUS
NDA
21 sections
CLINIMIX
HUMAN PRESCRIPTION DRUG LABEL
16
0338-0188
INJECTION
384 mg
INTRAVENOUS
NDA
21 sections
CLINIMIX
HUMAN PRESCRIPTION DRUG LABEL
16
0338-0188
INJECTION
384 mg
INTRAVENOUS
NDA
21 sections
CLINIMIX
HUMAN PRESCRIPTION DRUG LABEL
16
0338-0194
INJECTION
384 mg
INTRAVENOUS
NDA
21 sections
CLINIMIX
HUMAN PRESCRIPTION DRUG LABEL
16
0338-0194
INJECTION
384 mg
INTRAVENOUS
NDA
21 sections
CLINIMIX
HUMAN PRESCRIPTION DRUG LABEL
16
0338-0198
INJECTION
288 mg
INTRAVENOUS
NDA
21 sections
CLINIMIX
HUMAN PRESCRIPTION DRUG LABEL
16
0338-0198
INJECTION
288 mg
INTRAVENOUS
NDA
21 sections
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Structure 🔎
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L1000
FAQ
histidine