Stem definition | Drug id | CAS RN |
---|---|---|
1364 | 70-30-4 |
None
None
Date | Agency | Company | Orphan |
---|---|---|---|
April 19, 1949 | FDA | SANOFI AVENTIS US |
None
None
None
None
Source | Code | Description |
---|---|---|
ATC | D08AE01 | DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Phenol and derivatives |
FDA EPC | N0000175486 | Antiseptic |
MeSH PA | D000890 | Anti-Infective Agents |
MeSH PA | D000891 | Anti-Infective Agents, Local |
CHEBI has role | CHEBI:22153 | acaricides |
CHEBI has role | CHEBI:33282 | bactericides |
CHEBI has role | CHEBI:48218 | antiseptics |
CHEBI has role | CHEBI:86328 | anti-fungal agrichemical |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Burn injury | contraindication | 48333001 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Denuded skin | contraindication | 418242004 | |
CNS Toxicity | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 6.2 | acidic |
pKa2 | 8.97 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Prostaglandin G/H synthase 2 | Enzyme | IC50 | 6.19 | DRUG MATRIX | |||||
Adenosine receptor A2a | GPCR | Ki | 6.04 | DRUG MATRIX | |||||
Alpha-2A adrenergic receptor | GPCR | Ki | 5.69 | DRUG MATRIX | |||||
Sodium-dependent serotonin transporter | Transporter | Ki | 5.64 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 2B | GPCR | Ki | 5.44 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 2C | GPCR | Ki | 5.62 | DRUG MATRIX | |||||
Alpha-2C adrenergic receptor | GPCR | Ki | 5.99 | DRUG MATRIX | |||||
Adenosine receptor A3 | GPCR | Ki | 6.44 | DRUG MATRIX | |||||
Estrogen receptor | Nuclear hormone receptor | IC50 | 5.67 | CHEMBL | |||||
Estrogen receptor beta | Nuclear hormone receptor | IC50 | 7.01 | CHEMBL | |||||
Cytochrome P450 1A2 | Enzyme | IC50 | 5.88 | DRUG MATRIX | |||||
Epidermal growth factor receptor | Kinase | IC50 | 6.13 | DRUG MATRIX | |||||
Cytochrome P450 2C19 | Enzyme | IC50 | 5.91 | DRUG MATRIX | |||||
Tyrosine-protein kinase Lck | Kinase | IC50 | 5.61 | DRUG MATRIX | |||||
Tyrosine-protein kinase Fyn | Kinase | IC50 | 5.46 | DRUG MATRIX | |||||
Receptor tyrosine-protein kinase erbB-2 | Kinase | IC50 | 5.48 | DRUG MATRIX | |||||
Thromboxane-A synthase | Enzyme | IC50 | 5.51 | DRUG MATRIX | |||||
Mitogen-activated protein kinase 3 | Kinase | IC50 | 5.61 | DRUG MATRIX | |||||
Mitogen-activated protein kinase 14 | Kinase | IC50 | 7.06 | DRUG MATRIX | |||||
Substance-K receptor | GPCR | Ki | 5.86 | DRUG MATRIX | |||||
Mitogen-activated protein kinase 1 | Kinase | IC50 | 6.71 | DRUG MATRIX | |||||
Transitional endoplasmic reticulum ATPase | Enzyme | IC50 | 5.26 | CHEMBL | |||||
Heat shock cognate 71 kDa protein | Unclassified | IC50 | 4.56 | CHEMBL | |||||
Heat shock 70 kDa protein 1A | Unclassified | IC50 | 4.72 | CHEMBL | |||||
Macrophage migration inhibitory factor | Unclassified | Ki | 5.26 | CHEMBL | |||||
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D | Unclassified | INHIBITOR | IC50 | 5.01 | IUPHAR | ||||
78 kDa glucose-regulated protein | Unclassified | IC50 | 5.04 | CHEMBL | |||||
Acetylcholinesterase | Enzyme | IC50 | 5.52 | DRUG MATRIX | |||||
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI | Enzyme | INHIBITOR | CHEMBL | CHEMBL | |||||
Sodium/potassium-transporting ATPase subunit alpha-2 | Ion channel | IC50 | 5.21 | DRUG MATRIX | |||||
D-lactate dehydrogenase | Enzyme | WOMBAT-PK | |||||||
Androgen receptor | Transcription factor | Ki | 5.48 | DRUG MATRIX | |||||
Zinc finger protein mex-5 | Cytosolic other | EC50 | 4.72 | CHEMBL | |||||
M1-family alanyl aminopeptidase | Enzyme | IC50 | 4.24 | CHEMBL | |||||
Cytoplasmic zinc-finger protein | Unclassified | EC50 | 4.34 | CHEMBL | |||||
Envelope glycoprotein gp160 | Viral envelope protein | IC50 | 5.14 | CHEMBL | |||||
Envelope glycoprotein gp160 [Cleaved into: Surface protein gp120 | Unclassified | IC50 | 5.14 | CHEMBL | |||||
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D, N-acyl phosphatidylethanolamine phospholipase D, NAPE-PLD, NAPE-hydrolyzing phospholipase D, EC 3.1.4.54 | Unclassified | IC50 | 4.96 | CHEMBL |
ID | Source |
---|---|
4018252 | VUID |
N0000146582 | NUI |
D00859 | KEGG_DRUG |
4018252 | VANDF |
C0019435 | UMLSCUI |
CHEBI:5693 | CHEBI |
CHEMBL496 | ChEMBL_ID |
D006582 | MESH_DESCRIPTOR_UI |
DB00756 | DRUGBANK_ID |
3598 | PUBCHEM_CID |
11069 | IUPHAR_LIGAND_ID |
2033 | INN_ID |
IWW5FV6NK2 | UNII |
5293 | RXNORM |
4826 | MMSL |
71944 | MMSL |
741 | MMSL |
003176 | NDDF |
1878008 | SNOMEDCT_US |
387103004 | SNOMEDCT_US |
None