All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

heparin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
heparin derivatives including low molecular mass heparins	1358	9005-49-6

Description:

Molecule

Description

Synonyms: heparin heparin sodium heparin calcium

A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
10	TU	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Bocci G, Oprea TI, Benet LZ

Approvals:

Date	Agency	Company	Orphan
Feb. 9, 1939	FDA	ORGANON USA INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Heparin-induced thrombocytopenia	2813.58	11.50	676	53639	3906	63430801
Premature delivery	427.37	11.50	286	54029	29995	63404712
Shock haemorrhagic	255.82	11.50	138	54177	9757	63424950
Haemorrhage	239.62	11.50	278	54037	60744	63373963
Hereditary angioedema	234.12	11.50	119	54196	7443	63427264
Labelled drug-drug interaction medication error	212.01	11.50	136	54179	13263	63421444
Maternal exposure during pregnancy	211.05	11.50	533	53782	219529	63215178
Exposure during pregnancy	205.88	11.50	428	53887	155119	63279588
Thrombocytopenia	204.86	11.50	420	53895	150737	63283970
Vascular stent thrombosis	184.54	11.50	57	54258	920	63433787
Cerebral haemorrhage	183.23	11.50	175	54140	30554	63404153
Rheumatoid arthritis	179.89	11.50	9	54306	253810	63180897
Haematoma	179.22	11.50	183	54132	34637	63400070
Joint swelling	177.28	11.50	33	54282	327633	63107074
Drug intolerance	173.74	11.50	28	54287	308633	63126074
Pulmonary embolism	163.69	11.50	329	53986	116355	63318352
Retroperitoneal haematoma	162.68	11.50	69	54246	2844	63431863
Retroperitoneal haemorrhage	158.69	11.50	67	54248	2730	63431977
Arthropathy	158.25	11.50	11	54304	234781	63199926
Haemorrhage intracranial	152.42	11.50	111	54204	13308	63421399
Alopecia	146.43	11.50	53	54262	337483	63097224
Abdominal wall haematoma	143.33	11.50	64	54251	2991	63431716
Pemphigus	138.71	11.50	4	54311	183722	63250985
Acute kidney injury	132.64	11.50	510	53805	262905	63171802
Arthralgia	128.97	11.50	180	54135	569530	62865177
Thrombosis in device	128.75	11.50	59	54256	2931	63431776
Premature baby	125.33	11.50	119	54196	20616	63414091
Thrombosis	120.15	11.50	206	54109	64549	63370158
Haematoma muscle	117.13	11.50	42	54273	1095	63433612
Abdominal discomfort	114.85	11.50	66	54249	320819	63113888
Multiple organ dysfunction syndrome	112.55	11.50	186	54129	56566	63378141
Cerebral infarction	111.16	11.50	119	54196	23774	63410933
Extradural haematoma	110.36	11.50	45	54270	1677	63433030
Vascular pseudoaneurysm	108.37	11.50	43	54272	1491	63433216
Aplastic anaemia	106.06	11.50	78	54237	9491	63425216
Systemic lupus erythematosus	104.77	11.50	25	54290	208893	63225814
Cardiac arrest	103.36	11.50	238	54077	92307	63342400
Haemothorax	103.23	11.50	46	54269	2139	63432568
Toxic epidermal necrolysis	98.67	11.50	115	54200	25219	63409488
Activated partial thromboplastin time prolonged	94.53	11.50	64	54251	6829	63427878
Spinal epidural haematoma	91.69	11.50	35	54280	1092	63433615
Pain	91.18	11.50	327	53988	740301	62694406
Haemoperitoneum	90.31	11.50	45	54270	2696	63432011
Low birth weight baby	90.24	11.50	63	54252	7066	63427641
Completed suicide	89.52	11.50	10	54305	145663	63289044
Cardiogenic shock	88.19	11.50	92	54223	17840	63416867
Pericarditis	86.23	11.50	7	54308	131572	63303135
Pharyngeal haemorrhage	85.81	11.50	28	54287	544	63434163
Wound	84.93	11.50	18	54297	163245	63271462
Product use in unapproved indication	82.97	11.50	338	53977	178742	63255965
Subdural haematoma	78.64	11.50	78	54237	14250	63420457
Sepsis	78.19	11.50	298	54017	152825	63281882
Compartment syndrome	76.74	11.50	38	54277	2246	63432461
Hypersensitivity	76.00	11.50	83	54232	292602	63142105
Swelling	73.84	11.50	76	54239	275302	63159405
Respiratory failure	71.98	11.50	221	54094	101637	63333070
Musculoskeletal stiffness	71.86	11.50	34	54281	184584	63250123
Coagulopathy	71.38	11.50	88	54227	20456	63414251
Peripheral ischaemia	71	11.50	47	54268	4831	63429876
Cardiac tamponade	69.48	11.50	46	54269	4729	63429978
Heparin-induced thrombocytopenia test positive	69.33	11.50	12	54303	4	63434703
Treatment failure	68.25	11.50	43	54272	199000	63235707
Hypotension	67.28	11.50	431	53884	272173	63162534
Off label use	67.16	11.50	875	53440	673587	62761120
Disseminated intravascular coagulation	66.82	11.50	82	54233	18969	63415738
Foetal death	66.32	11.50	63	54252	10917	63423790
Intracardiac thrombus	63.37	11.50	34	54281	2376	63432331
Haemoglobin decreased	62.98	11.50	269	54046	145216	63289491
Eosinophilia	61.27	11.50	86	54229	22670	63412037
Coagulation time prolonged	60.55	11.50	28	54287	1420	63433287
Subarachnoid haemorrhage	59.26	11.50	67	54248	14216	63420491
Discomfort	58.99	11.50	35	54280	167339	63267368
Deep vein thrombosis	58.43	11.50	181	54134	83619	63351088
Foetal exposure during pregnancy	58.36	11.50	101	54214	31861	63402846
Stevens-Johnson syndrome	58.04	11.50	88	54227	24862	63409845
Infective aneurysm	57.25	11.50	19	54296	390	63434317
Coronary artery thrombosis	57.10	11.50	25	54290	1114	63433593
Fatigue	56.85	11.50	487	53828	887541	62547166
Embolism	56.80	11.50	50	54265	7856	63426851
Blood cholesterol increased	56.40	11.50	7	54308	94025	63340682
Muscle haemorrhage	54.61	11.50	34	54281	3145	63431562
Blood pressure decreased	54.51	11.50	150	54165	64872	63369835
Encephalopathy	54.20	11.50	109	54206	38511	63396196
Arthritis	54.05	11.50	16	54299	115905	63318802
Subchorionic haematoma	53.70	11.50	14	54301	117	63434590
Hypoxia	53.19	11.50	141	54174	59651	63375056
Hepatic enzyme increased	52.90	11.50	57	54258	202271	63232436
Oesophageal intramural haematoma	52.79	11.50	13	54302	84	63434623
Mobility decreased	52.48	11.50	19	54296	121140	63313567
Weight increased	52.48	11.50	89	54226	260703	63174004
Irritable bowel syndrome	52.31	11.50	5	54310	82407	63352300
Contraindicated product administered	51.88	11.50	66	54249	217582	63217125
Gastrointestinal haemorrhage	51.73	11.50	170	54145	81006	63353701
Rash	51.58	11.50	276	54039	560595	62874112
Caesarean section	51.35	11.50	68	54247	16964	63417743
Acute motor-sensory axonal neuropathy	50.97	11.50	16	54299	273	63434434
Coagulation time shortened	50.33	11.50	14	54301	153	63434554
Venous thrombosis	49.96	11.50	38	54277	4864	63429843
Procedural haemorrhage	49.36	11.50	30	54285	2658	63432049
Choroidal infarction	49.35	11.50	12	54303	73	63434634
Ischaemic stroke	48.54	11.50	68	54247	17889	63416818
Haemodynamic instability	48.54	11.50	49	54266	9141	63425566
Loss of personal independence in daily activities	48.04	11.50	12	54303	97278	63337429
Lower respiratory tract infection	47.56	11.50	27	54288	132280	63302427
Pulmonary alveolar haemorrhage	47.16	11.50	36	54279	4632	63430075
Mixed liver injury	46.71	11.50	36	54279	4699	63430008
Psoriasis	46.42	11.50	9	54306	86948	63347759
Antiphospholipid syndrome	46.36	11.50	25	54290	1765	63432942
Impaired healing	46.28	11.50	15	54300	102527	63332180
Anaemia	45.92	11.50	417	53898	293013	63141694
Intentional overdose	45.77	11.50	5	54310	74147	63360560
Cerebral haematoma	45.34	11.50	32	54283	3651	63431056
Heparin resistance	45.28	11.50	8	54307	4	63434703
Aortic thrombosis	45.17	11.50	21	54294	1078	63433629
Intraventricular haemorrhage	45.05	11.50	26	54289	2094	63432613
Toxicity to various agents	44.75	11.50	90	54225	247160	63187547
Therapeutic product effect decreased	44.58	11.50	60	54255	193127	63241580
Drug abuse	44.48	11.50	5	54310	72513	63362194
Adrenal haemorrhage	44.09	11.50	16	54299	432	63434275
Incorrect drug administration rate	43.24	11.50	32	54283	3930	63430777
Injection site pain	43.17	11.50	29	54286	129771	63304936
Pericardial haemorrhage	43.01	11.50	23	54292	1596	63433111
Septic shock	42.86	11.50	140	54175	66489	63368218
Haemorrhagic transformation stroke	42.84	11.50	21	54294	1214	63433493
Skin necrosis	42.53	11.50	56	54259	13894	63420813
Hyperkalaemia	42.44	11.50	122	54193	54081	63380626
Platelet count decreased	42.23	11.50	204	54111	115918	63318789
Shock	41.35	11.50	73	54242	23390	63411317
Pulmonary infarction	41.27	11.50	27	54288	2720	63431987
Rash maculo-papular	41.20	11.50	87	54228	31809	63402898
Ocular retrobulbar haemorrhage	40.89	11.50	11	54304	105	63434602
Therapeutic product effect incomplete	40.19	11.50	29	54286	125027	63309680
Orbital compartment syndrome	40.17	11.50	10	54305	68	63434639
Catheter site haemorrhage	40.05	11.50	28	54287	3147	63431560
Spinal cord compression	39.75	11.50	31	54284	4117	63430590
Abdominal compartment syndrome	39.73	11.50	16	54299	577	63434130
Acute myocardial infarction	39.62	11.50	86	54229	32038	63402669
Acute generalised exanthematous pustulosis	39.29	11.50	48	54267	11051	63423656
Vena cava thrombosis	39.11	11.50	24	54291	2163	63432544
Peripheral artery thrombosis	39.06	11.50	23	54292	1923	63432784
Platelet aggregation inhibition	38.69	11.50	11	54304	131	63434576
Ill-defined disorder	38.63	11.50	11	54304	81744	63352963
Brain herniation	38.57	11.50	29	54286	3648	63431059
Cardiac valve replacement complication	37.60	11.50	11	54304	146	63434561
Hypercoagulation	37.59	11.50	23	54292	2062	63432645
Cerebellar haemorrhage	37.59	11.50	20	54295	1374	63433333
Rectosigmoid cancer	37.39	11.50	11	54304	149	63434558
HELLP syndrome	36.96	11.50	18	54297	1026	63433681
Insomnia	36.72	11.50	81	54234	215171	63219536
Oliguria	36.58	11.50	42	54273	9059	63425648
Folliculitis	36.04	11.50	8	54307	70309	63364398
Depression	35.99	11.50	71	54244	196421	63238286
Pulseless electrical activity	35.93	11.50	38	54277	7483	63427224
Toxoplasmosis	35.93	11.50	20	54295	1503	63433204
Gait disturbance	35.48	11.50	64	54251	183114	63251593
Suicide attempt	35.42	11.50	5	54310	60913	63373794
Memory impairment	35.06	11.50	23	54292	104235	63330472
Osteoarthritis	34.92	11.50	19	54296	95324	63339383
Gangrene	34.84	11.50	34	54281	6089	63428618
Electrocardiogram ST segment elevation	34.74	11.50	28	54287	3899	63430808
Premature rupture of membranes	34.72	11.50	31	54284	4962	63429745
Haemorrhagic infarction	34.52	11.50	12	54303	285	63434422
Puncture site haemorrhage	34.28	11.50	12	54303	291	63434416
Arterial thrombosis	34.18	11.50	19	54296	1424	63433283
Peripheral swelling	34.17	11.50	115	54200	265827	63168880
Spinal subdural haematoma	33.89	11.50	10	54305	137	63434570
Febrile neutropenia	33.40	11.50	194	54121	118255	63316452
Thrombotic microangiopathy	33.13	11.50	43	54272	10518	63424189
Splenic rupture	32.74	11.50	18	54297	1320	63433387
Hypervolaemia	32.71	11.50	74	54241	28339	63406368
Paraplegia	32.39	11.50	23	54292	2649	63432058
Suicidal ideation	32.20	11.50	7	54308	62414	63372293
Tonsillar haemorrhage	32.09	11.50	11	54304	250	63434457
Vascular access site haemorrhage	31.76	11.50	6	54309	7	63434700
Dry gangrene	31.52	11.50	14	54301	646	63434061
Type 2 diabetes mellitus	31.29	11.50	8	54307	63860	63370847
Ventricular tachycardia	31.21	11.50	59	54256	19920	63414787
Insurance issue	31.17	11.50	32	54283	6089	63428618
Respiratory distress	31.14	11.50	81	54234	33870	63400837
Hyperlactacidaemia	31.07	11.50	23	54292	2826	63431881
Normal newborn	31.04	11.50	37	54278	8304	63426403
Tachypnoea	30.70	11.50	54	54261	17248	63417459
Transfusion	30.32	11.50	50	54265	15167	63419540
Atrial thrombosis	30.11	11.50	19	54296	1799	63432908
Transcription medication error	29.83	11.50	10	54305	212	63434495
Confusional state	29.83	11.50	103	54212	236277	63198430
Malaise	29.75	11.50	221	54094	415733	63018974
Hemiparesis	29.48	11.50	63	54252	23219	63411488
Nasopharyngitis	29.32	11.50	115	54200	254142	63180565
Intentional product misuse	29.14	11.50	8	54307	60909	63373798
Post procedural haemorrhage	29.10	11.50	35	54280	7929	63426778
Acute respiratory distress syndrome	29.02	11.50	63	54252	23471	63411236
Vaginal haemorrhage	28.81	11.50	69	54246	27418	63407289
Drug reaction with eosinophilia and systemic symptoms	28.29	11.50	78	54237	33758	63400949
Device related infection	28.14	11.50	62	54253	23330	63411377
Drug ineffective	27.77	11.50	682	53633	1044083	62390624
Embolic cerebral infarction	27.70	11.50	12	54303	521	63434186
Product administration error	27.67	11.50	60	54255	22337	63412370
Anti factor Xa activity decreased	27.39	11.50	5	54310	4	63434703
COVID-19	27.32	11.50	178	54137	112925	63321782
Intracranial haematoma	27.25	11.50	11	54304	399	63434308
Cholestasis	26.77	11.50	70	54245	29364	63405343
Fibromyalgia	26.69	11.50	18	54297	80402	63354305
Inflammation	26.53	11.50	19	54296	82254	63352453
Anticoagulation drug level above therapeutic	26.31	11.50	16	54299	1419	63433288
Haematuria	26.17	11.50	69	54246	29088	63405619
Arterial haemorrhage	26.10	11.50	17	54298	1700	63433007
Urinary tract infection	26.00	11.50	343	53972	264341	63170366
Choroidal effusion	25.67	11.50	11	54304	465	63434242
Vascular graft occlusion	25.57	11.50	9	54306	222	63434485
Vasodilatation	25.37	11.50	19	54296	2376	63432331
Intra-abdominal haematoma	25.33	11.50	17	54298	1788	63432919
Hip arthroplasty	25.28	11.50	5	54310	47641	63387066
Injection site swelling	25.23	11.50	5	54310	47567	63387140
Asthma	25.20	11.50	44	54271	127517	63307190
Haemolysis	25.15	11.50	30	54285	6738	63427969
Procedural complication	25.13	11.50	27	54288	5412	63429295
Injury	24.84	11.50	16	54299	73231	63361476
Spontaneous haematoma	24.61	11.50	13	54302	880	63433827
Cerebral amyloid angiopathy	24.58	11.50	8	54307	154	63434553
Gastrointestinal disorder	24.39	11.50	47	54268	131192	63303515
Stress cardiomyopathy	24.38	11.50	35	54280	9415	63425292
Dizziness	24.23	11.50	243	54072	429682	63005025
Foetal growth restriction	24.08	11.50	31	54284	7522	63427185
Central venous catheterisation	23.99	11.50	19	54296	2580	63432127
Drug chemical incompatibility	23.85	11.50	7	54308	94	63434613
Pseudohypoaldosteronism	23.66	11.50	5	54310	14	63434693
Renal infarct	23.66	11.50	15	54300	1432	63433275
Lipoedema	23.33	11.50	9	54306	289	63434418
Splenic infarction	23.33	11.50	16	54299	1743	63432964
Subcapsular renal haematoma	23.22	11.50	9	54306	293	63434414
Product measured potency issue	22.95	11.50	7	54308	108	63434599
Arterial intramural haematoma	22.93	11.50	5	54310	17	63434690
Cardiac ventricular thrombosis	22.90	11.50	11	54304	608	63434099
Blister	22.83	11.50	48	54267	129766	63304941
Spinal cord disorder	22.76	11.50	14	54301	1267	63433440
Intra-abdominal haemorrhage	22.68	11.50	18	54297	2451	63432256
Rhinocerebral mucormycosis	22.64	11.50	10	54305	455	63434252
Adverse event	22.58	11.50	15	54300	67544	63367163
Epistaxis	22.40	11.50	122	54193	72603	63362104
Live birth	22.34	11.50	60	54255	25570	63409137
Ventricular fibrillation	22.32	11.50	38	54277	11829	63422878
Blood pressure fluctuation	22.31	11.50	6	54309	46311	63388396
Hydrocephalus	22.22	11.50	25	54290	5275	63429432
Coagulation factor VIII level increased	22.10	11.50	5	54310	21	63434686
Pituitary apoplexy	21.95	11.50	7	54308	126	63434581
Renal failure	21.95	11.50	174	54141	117478	63317229
Pulse absent	21.94	11.50	25	54290	5349	63429358
Weight decreased	21.76	11.50	143	54172	276655	63158052
Posthaemorrhagic hydrocephalus	21.73	11.50	5	54310	23	63434684
Paratonia	21.73	11.50	5	54310	23	63434684
Haemorrhage subcutaneous	21.70	11.50	19	54296	2964	63431743
Human herpesvirus 6 infection reactivation	21.35	11.50	9	54306	365	63434342
Anticoagulation drug level below therapeutic	21.32	11.50	11	54304	709	63433998
Phaeochromocytoma crisis	21.10	11.50	8	54307	245	63434462
Medical device site thrombosis	21.02	11.50	4	54311	5	63434702
Cerebral venous thrombosis	20.96	11.50	16	54299	2058	63432649
Pre-eclampsia	20.94	11.50	32	54283	9101	63425606
Haemoptysis	20.90	11.50	63	54252	28663	63406044
Diarrhoea	20.88	11.50	460	53855	714906	62719801
Premature labour	20.87	11.50	38	54277	12466	63422241
Renal vein thrombosis	20.73	11.50	9	54306	393	63434314
Stillbirth	20.42	11.50	27	54288	6723	63427984
Coagulation time abnormal	20.41	11.50	6	54309	81	63434626
Hepatic function abnormal	20.35	11.50	74	54241	37068	63397639
Coronary artery perforation	20.34	11.50	5	54310	32	63434675
Sleep disorder	20.18	11.50	24	54291	81542	63353165
Pericardial effusion	20.09	11.50	64	54251	29994	63404713
Pelvic haematoma	20.07	11.50	10	54305	599	63434108
Acute respiratory failure	20	11.50	70	54245	34415	63400292
Atheroembolism	19.87	11.50	4	54311	8	63434699
Suspected transmission of an infectious agent via product	19.72	11.50	8	54307	294	63434413
Protein C decreased	19.71	11.50	5	54310	37	63434670
Drug ineffective for unapproved indication	19.63	11.50	69	54246	33994	63400713
Peritoneal haematoma	19.53	11.50	6	54309	95	63434612
Brain death	19.52	11.50	19	54296	3391	63431316
Patent ductus arteriosus	19.47	11.50	21	54294	4229	63430478
Postpartum haemorrhage	19.40	11.50	15	54300	1966	63432741
Hepatic haematoma	19.32	11.50	9	54306	464	63434243
Catheter site pain	19.28	11.50	22	54293	4713	63429994
Injection site erythema	19.00	11.50	26	54289	83148	63351559
Organic brain syndrome	18.79	11.50	7	54308	204	63434503
Blood albumin decreased	18.74	11.50	40	54275	14726	63419981
Candida infection	18.61	11.50	60	54255	28291	63406416
Haemodialysis complication	18.56	11.50	7	54308	211	63434496
Stomatitis	18.48	11.50	59	54256	138666	63296041
Cardiac failure	18.39	11.50	135	54180	89007	63345700
Kidney rupture	18.38	11.50	5	54310	50	63434657
Necrosis	18.25	11.50	23	54292	5464	63429243
Cerebral artery embolism	18.20	11.50	11	54304	965	63433742
Hand amputation	18.19	11.50	3	54312	0	63434707
Coronary vascular graft occlusion	18.19	11.50	3	54312	0	63434707
Ureteric haemorrhage	18.19	11.50	3	54312	0	63434707
Cerebellar embolism	18.19	11.50	3	54312	0	63434707
Adverse drug reaction	18.13	11.50	25	54290	79689	63355018
Injection site pruritus	18.02	11.50	8	54307	45108	63389599
Product contamination	17.98	11.50	10	54305	750	63433957
Wheezing	17.96	11.50	34	54281	95561	63339146
Melaena	17.92	11.50	62	54253	30303	63404404
Myelomalacia	17.86	11.50	5	54310	56	63434651
Cerebral reperfusion injury	17.84	11.50	4	54311	16	63434691
Infection	17.70	11.50	119	54196	229054	63205653
Pulmonary fibrosis	17.65	11.50	6	54309	39803	63394904
Brain oedema	17.50	11.50	38	54277	14157	63420550
Recurrence of neuromuscular blockade	17.44	11.50	6	54309	138	63434569
Platelet transfusion	17.43	11.50	10	54305	796	63433911
Joint stiffness	17.40	11.50	7	54308	41862	63392845
Calciphylaxis	17.37	11.50	17	54298	3055	63431652
Atrial rupture	17.33	11.50	5	54310	63	63434644
Arm amputation	17.28	11.50	4	54311	19	63434688
Jugular vein thrombosis	17.16	11.50	17	54298	3101	63431606
Device occlusion	17.10	11.50	26	54289	7361	63427346
Spinal cord oedema	17.08	11.50	6	54309	147	63434560
Threatened labour	16.90	11.50	10	54305	844	63433863
General physical health deterioration	16.87	11.50	102	54213	201300	63233407
Peritonitis	16.85	11.50	42	54273	17112	63417595
Gestational hypertension	16.79	11.50	15	54300	2402	63432305
Bullous haemorrhagic dermatosis	16.78	11.50	5	54310	71	63434636
Device related sepsis	16.63	11.50	19	54296	4075	63430632
Product administered to patient of inappropriate age	16.48	11.50	17	54298	3251	63431456
Leukocyturia	16.48	11.50	12	54303	1437	63433270
Ischaemic hepatitis	16.45	11.50	14	54301	2102	63432605
Hepatic infarction	16.23	11.50	9	54306	671	63434036
Hepatic artery occlusion	16.22	11.50	4	54311	26	63434681
Dyspepsia	16.17	11.50	40	54275	102156	63332551
Pseudomonas infection	16.15	11.50	32	54283	11181	63423526
Autoimmune heparin-induced thrombocytopenia	16.12	11.50	3	54312	3	63434704
Joint range of motion decreased	16.00	11.50	4	54311	32424	63402283
Mucosal erosion	16.00	11.50	12	54303	1504	63433203
Enterococcal infection	15.92	11.50	26	54289	7822	63426885
Hypoaldosteronism	15.91	11.50	6	54309	181	63434526
Endocarditis	15.88	11.50	22	54293	5728	63428979
Iliac artery occlusion	15.85	11.50	6	54309	183	63434524
Capillary fragility test	15.84	11.50	4	54311	29	63434678
Cholestatic liver injury	15.81	11.50	15	54300	2595	63432112
Myalgia	15.79	11.50	68	54247	146461	63288246
Wrong technique in product usage process	15.79	11.50	18	54297	62322	63372385
Haemorrhagic stroke	15.75	11.50	22	54293	5770	63428937
Bursitis	15.71	11.50	6	54309	37035	63397672
Serratia infection	15.69	11.50	10	54305	963	63433744
Aneurysm recanalisation	15.66	11.50	3	54312	4	63434703
Drug-device interaction	15.63	11.50	5	54310	91	63434616
Fungal sepsis	15.55	11.50	11	54304	1259	63433448
Tachycardia	15.53	11.50	162	54153	117994	63316713
Protein S decreased	15.50	11.50	4	54311	32	63434675
Gastrooesophageal reflux disease	15.48	11.50	37	54278	95602	63339105
Post procedural haematoma	15.44	11.50	11	54304	1274	63433433
Ventricle rupture	15.39	11.50	4	54311	33	63434674
COVID-19 pneumonia	15.25	11.50	36	54279	14173	63420534
Dry mouth	15.24	11.50	27	54288	77836	63356871
Cerebrovascular disorder	15.23	11.50	15	54300	2717	63431990
Hemiplegia	15.14	11.50	28	54287	9295	63425412
Fibrin D dimer increased	15.02	11.50	20	54295	5014	63429693
Tricuspid valve stenosis	14.90	11.50	3	54312	6	63434701
Heparin-induced thrombocytopenia test	14.90	11.50	3	54312	6	63434701
Protein S increased	14.90	11.50	3	54312	6	63434701
Prosthetic cardiac valve thrombosis	14.89	11.50	4	54311	38	63434669
Clostridium difficile colitis	14.86	11.50	45	54270	20524	63414183
Pulmonary haemorrhage	14.85	11.50	24	54291	7157	63427550
Cerebral artery thrombosis	14.81	11.50	7	54308	373	63434334
Plantar erythema	14.80	11.50	6	54309	220	63434487
Night sweats	14.80	11.50	12	54303	48802	63385905
Right ventricular failure	14.74	11.50	40	54275	17148	63417559
Petechiae	14.69	11.50	35	54280	13862	63420845
Purpura	14.64	11.50	31	54284	11354	63423353
Medical device site haemorrhage	14.61	11.50	4	54311	41	63434666
Blood loss anaemia	14.58	11.50	27	54288	8974	63425733
Electrocardiogram T wave alternans	14.53	11.50	4	54311	42	63434665
Nervous system disorder	14.45	11.50	42	54273	18724	63415983
Red blood cell sedimentation rate increased	14.38	11.50	10	54305	43972	63390735
Spinal cord haemorrhage	14.36	11.50	6	54309	238	63434469
Eosinophil cationic protein increased	14.36	11.50	4	54311	44	63434663
Ischaemia	14.30	11.50	19	54296	4753	63429954
Blood creatinine increased	14.29	11.50	126	54189	87718	63346989
Obstructive shock	14.28	11.50	4	54311	45	63434662
Herpes simplex hepatitis	14.18	11.50	7	54308	411	63434296
Abdominal pain upper	14.10	11.50	111	54204	206333	63228374
Thrombolysis	14.07	11.50	5	54310	127	63434580
Vascular parkinsonism	14.07	11.50	5	54310	127	63434580
Atrial fibrillation	13.97	11.50	157	54158	116479	63318228
Haemorrhagic cerebral infarction	13.89	11.50	8	54307	642	63434065
Immune thrombocytopenia	13.87	11.50	29	54286	10527	63424180
Cerebral mass effect	13.78	11.50	9	54306	904	63433803
Foetal exposure timing unspecified	13.77	11.50	6	54309	264	63434443
Gait inability	13.73	11.50	15	54300	52944	63381763
International normalised ratio increased	13.71	11.50	77	54238	46348	63388359
Dry eye	13.69	11.50	9	54306	40752	63393955
Therapeutic product effect increased	13.68	11.50	10	54305	1205	63433502
Subdural haemorrhage	13.57	11.50	15	54300	3103	63431604
Epidermolysis	13.56	11.50	8	54307	671	63434036
Renal haemorrhage	13.51	11.50	9	54306	935	63433772
Anxiety	13.49	11.50	120	54195	217421	63217286
Injection site plaque	13.44	11.50	5	54310	145	63434562
Cardiopulmonary failure	13.40	11.50	16	54299	3596	63431111
Visual impairment	13.40	11.50	33	54282	84413	63350294
Balance disorder	13.39	11.50	33	54282	84389	63350318
Type III immune complex mediated reaction	13.38	11.50	6	54309	283	63434424
Thrombin time abnormal	13.38	11.50	3	54312	12	63434695
Blood creatine increased	13.37	11.50	20	54295	5581	63429126
Haemoglobin abnormal	13.35	11.50	19	54296	5069	63429638
Pyrexia	13.33	11.50	510	53805	469968	62964739
Cardiac valve vegetation	13.30	11.50	6	54309	287	63434420
Pulmonary artery thrombosis	13.23	11.50	8	54307	702	63434005
Infusion site pain	13.23	11.50	38	54277	16831	63417876
Nonreassuring foetal heart rate pattern	13.22	11.50	4	54311	60	63434647
Cerebrovascular accident	13.21	11.50	146	54169	107878	63326829
Dermatitis bullous	13.13	11.50	25	54290	8483	63426224
Pain in extremity	13.12	11.50	202	54113	331284	63103423
Muscle spasms	13.12	11.50	79	54236	156071	63278636
Peripheral artery occlusion	13.09	11.50	10	54305	1288	63433419
Neurological symptom	12.89	11.50	20	54295	5763	63428944
Agranulocytosis	12.87	11.50	49	54266	25085	63409622
Basal cell carcinoma	12.79	11.50	4	54311	27987	63406720
Foot deformity	12.69	11.50	4	54311	27849	63406858
Product use issue	12.66	11.50	124	54191	220396	63214311
Ventricular enlargement	12.65	11.50	4	54311	70	63434637
Acute pulmonary oedema	12.63	11.50	24	54291	8134	63426573
Haematidrosis	12.54	11.50	4	54311	72	63434635
Hypernatraemia	12.54	11.50	23	54292	7586	63427121
Hypovolaemia	12.51	11.50	28	54287	10645	63424062
Apgar score low	12.50	11.50	8	54307	776	63433931
Wound haematoma	12.49	11.50	4	54311	73	63434634
Upper respiratory tract infection	12.49	11.50	116	54199	81931	63352776
Peritonitis bacterial	12.48	11.50	18	54297	4861	63429846
Stoma site haemorrhage	12.48	11.50	9	54306	1062	63433645
Obesity	12.46	11.50	5	54310	29947	63404760
Catheter site haematoma	12.45	11.50	5	54310	179	63434528
Angiogram	12.44	11.50	4	54311	74	63434633
Pulmonary oedema	12.42	11.50	85	54230	54788	63379919
Seizure like phenomena	12.42	11.50	9	54306	1070	63433637
Bradycardia	12.41	11.50	106	54209	73121	63361586
Pelvic venous thrombosis	12.41	11.50	11	54304	1744	63432963
Dysgeusia	12.37	11.50	13	54302	46697	63388010
Arterial rupture	12.32	11.50	6	54309	342	63434365
Fistula discharge	12.32	11.50	9	54306	1084	63433623
Leg amputation	12.28	11.50	12	54303	2152	63432555
Circulatory collapse	12.26	11.50	44	54271	21894	63412813
Bladder spasm	12.23	11.50	11	54304	1777	63432930
Cognitive disorder	12.20	11.50	18	54297	55797	63378910
Cardiovascular insufficiency	12.17	11.50	10	54305	1431	63433276
Limbal swelling	12.10	11.50	3	54312	20	63434687
Toxic skin eruption	12.08	11.50	31	54284	12854	63421853
Amnesia	12.08	11.50	18	54297	55567	63379140
Portal vein thrombosis	12.05	11.50	13	54302	2617	63432090
Feeling abnormal	11.98	11.50	76	54239	148316	63286391
Cytokine release syndrome	11.96	11.50	33	54282	14281	63420426
Ankle brachial index decreased	11.92	11.50	4	54311	85	63434622
Pulse waveform abnormal	11.92	11.50	4	54311	85	63434622
Premature separation of placenta	11.85	11.50	11	54304	1850	63432857
Coronary artery dissection	11.81	11.50	8	54307	854	63433853
Splenic haemorrhage	11.79	11.50	5	54310	206	63434501
Blood phosphorus increased	11.78	11.50	14	54301	3131	63431576
Somnolence	11.77	11.50	97	54218	178588	63256119
Immune effector cell-associated neurotoxicity syndrome	11.77	11.50	12	54303	2265	63432442
Carotid intima-media thickness increased	11.75	11.50	4	54311	89	63434618
Catheter placement	11.74	11.50	12	54303	2272	63432435
Breast haematoma	11.68	11.50	5	54310	211	63434496
Paralysis	11.64	11.50	26	54289	9874	63424833
Procedural hypotension	11.63	11.50	9	54306	1181	63433526
Cardiac dysfunction	11.60	11.50	12	54303	2303	63432404
Intestinal ischaemia	11.59	11.50	22	54293	7446	63427261
Cerebral artery occlusion	11.54	11.50	8	54307	887	63433820

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Heparin-induced thrombocytopenia	3468.11	11.81	938	53466	4657	34897870
Vascular stent thrombosis	368.05	11.81	147	54257	2788	34899739
Thrombocytopenia	247.81	11.81	664	53740	155583	34746944
Cardiogenic shock	244.83	11.81	252	54152	26366	34876161
Haematoma	229.35	11.81	239	54165	25366	34877161
Multiple organ dysfunction syndrome	227.84	11.81	419	53985	76147	34826380
Labelled drug-drug interaction medication error	209.83	11.81	179	54225	14760	34887767
Appendicolith	204.53	11.81	141	54263	8460	34894067
Haemorrhage	200.14	11.81	317	54087	51053	34851474
Ventricular fibrillation	187.42	11.81	204	54200	22750	34879777
Post procedural haemorrhage	167.37	11.81	123	54281	8166	34894361
Appendicitis	165.55	11.81	156	54248	14651	34887876
Thrombosis	163.89	11.81	287	54117	50171	34852356
Haemorrhage intracranial	152.09	11.81	154	54250	15792	34886735
Retroperitoneal haematoma	151.78	11.81	77	54327	2601	34899926
Cerebral haemorrhage	143.54	11.81	221	54183	34716	34867811
Shock haemorrhagic	143.24	11.81	128	54276	11226	34891301
Cardiac tamponade	138.73	11.81	92	54312	5174	34897353
Heparin resistance	134.73	11.81	28	54376	26	34902501
Fatigue	134.64	11.81	232	54172	370421	34532106
Thrombosis in device	130.75	11.81	75	54329	3250	34899277
Arterial thrombosis	120.61	11.81	55	54349	1460	34901067
Drug abuse	119.85	11.81	9	54395	99087	34803440
Coagulation time shortened	112.28	11.81	32	54372	197	34902330
Pulmonary embolism	109.76	11.81	348	54056	89398	34813129
Arthralgia	105.96	11.81	67	54337	169974	34732553
Sepsis	104.67	11.81	524	53880	166037	34736490
Activated partial thromboplastin time prolonged	97.93	11.81	92	54312	8603	34893924
Low birth weight baby	97.50	11.81	88	54316	7817	34894710
Toxicity to various agents	97.38	11.81	101	54303	200261	34702266
Premature baby	96.23	11.81	135	54269	19498	34883029
Off label use	95.65	11.81	1034	53370	418490	34484037
Retroperitoneal haemorrhage	92.31	11.81	57	54347	2831	34899696
Depression	88.83	11.81	21	54383	97077	34805450
Blood phosphorus increased	87.54	11.81	82	54322	7639	34894888
Septic shock	87.29	11.81	278	54126	71556	34830971
Weight decreased	85.49	11.81	89	54315	176212	34726315
Stress	85.03	11.81	162	54242	30185	34872342
Drug reaction with eosinophilia and systemic symptoms	83.73	11.81	169	54235	32843	34869684
Heparin-induced thrombocytopenia test positive	82.75	11.81	22	54382	100	34902427
Brain herniation	82.09	11.81	60	54344	3948	34898579
Coagulation time prolonged	81.35	11.81	40	54364	1262	34901265
Compartment syndrome	77.74	11.81	52	54352	2966	34899561
Diarrhoea	75.91	11.81	331	54073	389581	34512946
Haematoma muscle	73.65	11.81	38	54366	1330	34901197
Intra-abdominal haemorrhage	73.18	11.81	46	54358	2358	34900169
Subarachnoid haemorrhage	71.22	11.81	93	54311	12542	34889985
Coagulation time	71.07	11.81	13	54391	0	34902527
Joint swelling	70.82	11.81	6	54398	59884	34842643
Eosinophilia	68.60	11.81	136	54268	26086	34876441
Disseminated intravascular coagulation	66.79	11.81	121	54283	21695	34880832
Intraventricular haemorrhage	65.92	11.81	50	54354	3481	34899046
Venous thrombosis	64.92	11.81	49	54355	3386	34899141
Cardiac ventricular thrombosis	64.71	11.81	33	54371	1127	34901400
Haemothorax	64.20	11.81	51	54353	3801	34898726
Muscle haemorrhage	63.63	11.81	50	54354	3668	34898859
Death	62.54	11.81	364	54040	397685	34504842
Deep vein thrombosis	62.22	11.81	233	54171	65015	34837512
Pericardial haemorrhage	59.58	11.81	45	54359	3113	34899414
Catheter site haemorrhage	58.93	11.81	39	54365	2185	34900342
Pulmonary haemorrhage	56.77	11.81	75	54329	10229	34892298
Cardiac arrest	56.42	11.81	297	54107	95862	34806665
Dizziness	55.31	11.81	166	54238	218355	34684172
Pharyngeal haemorrhage	55.31	11.81	26	54378	741	34901786
Decreased appetite	54.98	11.81	110	54294	166282	34736245
Rash maculo-papular	54.36	11.81	130	54274	28321	34874206
Fall	54.36	11.81	150	54254	202735	34699792
Acute kidney injury	53.95	11.81	717	53687	304271	34598256
Haemoglobin decreased	53.94	11.81	347	54057	120425	34782102
Intentional overdose	52.68	11.81	4	54400	43670	34858857
Haemodynamic instability	51.98	11.81	69	54335	9454	34893073
Insomnia	51.97	11.81	51	54353	103856	34798671
Abdominal distension	51.76	11.81	204	54200	58288	34844239
Procedural haemorrhage	50.81	11.81	37	54367	2420	34900107
Cerebral venous sinus thrombosis	50.63	11.81	22	54382	519	34902008
Product use in unapproved indication	50.28	11.81	334	54070	117165	34785362
Cerebral infarction	49.84	11.81	123	54281	27332	34875195
Malaise	49.31	11.81	138	54266	185687	34716840
Ascites	49.21	11.81	172	54232	46399	34856128
Rheumatoid arthritis	47.58	11.81	3	54401	38235	34864292
Coagulation time abnormal	47.10	11.81	15	54389	141	34902386
Product administration error	46.69	11.81	88	54316	16256	34886271
Weight increased	46.13	11.81	46	54358	92987	34809540
Arterial haemorrhage	46.05	11.81	24	54380	858	34901669
Asthenia	45.89	11.81	211	54193	245040	34657487
Pain	45.88	11.81	164	54240	204511	34698016
Acute respiratory distress syndrome	45.72	11.81	115	54289	25854	34876673
Hypotension	45.52	11.81	536	53868	221113	34681414
Pulseless electrical activity	45.26	11.81	56	54348	7155	34895372
Atrial thrombosis	45.01	11.81	33	54371	2181	34900346
Muscle spasms	44.69	11.81	31	54373	74970	34827557
Coronary artery thrombosis	43.49	11.81	32	54372	2127	34900400
Psoriasis	42.97	11.81	5	54399	38807	34863720
Myalgia	42.38	11.81	41	54363	84069	34818458
Coagulation test abnormal	42.10	11.81	20	54384	584	34901943
Adrenal haemorrhage	41.71	11.81	15	54389	210	34902317
Autoimmune heparin-induced thrombocytopenia	41.18	11.81	9	54395	13	34902514
Product measured potency issue	41.16	11.81	12	54392	81	34902446
Peripheral artery thrombosis	40.95	11.81	32	54372	2328	34900199
Coagulopathy	40.61	11.81	93	54311	19696	34882831
Product quality issue	40.57	11.81	85	54319	16950	34885577
Intracardiac thrombus	39.37	11.81	32	54372	2464	34900063
Incision site pain	38.74	11.81	28	54376	1810	34900717
Embolism	38.60	11.81	54	54350	7775	34894752
Memory impairment	38.36	11.81	10	54394	43308	34859219
Respiratory failure	37.95	11.81	294	54110	108278	34794249
Skin necrosis	37.61	11.81	46	54358	5807	34896720
Aortic thrombosis	37.30	11.81	20	54384	758	34901769
Ventricular tachycardia	37.05	11.81	108	54296	26471	34876056
Choroidal infarction	36.55	11.81	11	54393	84	34902443
Vascular stent occlusion	36.41	11.81	13	54391	178	34902349
Musculoskeletal stiffness	35.63	11.81	14	54390	46666	34855861
Product dose omission issue	34.70	11.81	85	54319	119626	34782901
Lymphocyte count decreased	34.54	11.81	95	54309	22527	34880000
Suspected product quality issue	34.53	11.81	12	54392	151	34902376
Aggression	34.50	11.81	9	54395	38955	34863572
Myasthenia gravis	34.41	11.81	48	54356	6892	34895635
Hereditary angioedema	34.32	11.81	21	54383	1026	34901501
Puncture site haemorrhage	33.77	11.81	14	54390	293	34902234
Gait disturbance	32.87	11.81	51	54353	85089	34817438
Abdominal discomfort	32.73	11.81	27	54377	59808	34842719
Cerebral hyperperfusion syndrome	32.09	11.81	10	54394	87	34902440
Chest wall haematoma	31.68	11.81	12	54392	196	34902331
Haemorrhagic transformation stroke	31.64	11.81	23	54381	1500	34901027
Renal infarct	31.40	11.81	22	54382	1354	34901173
Therapeutic product effect decreased	31.39	11.81	122	54282	34621	34867906
Jugular vein thrombosis	31.39	11.81	24	54380	1691	34900836
Balance disorder	31.34	11.81	12	54392	40642	34861885
Dehydration	31.22	11.81	101	54303	129868	34772659
Kounis syndrome	30.98	11.81	28	54376	2490	34900037
Arthropathy	30.98	11.81	3	54401	26904	34875623
Pulmonary haematoma	30.84	11.81	9	54395	61	34902466
Haemorrhagic infarction	30.83	11.81	15	54389	462	34902065
Peripheral ischaemia	30.72	11.81	41	54363	5646	34896881
Asthma	30.62	11.81	14	54390	42642	34859885
Haematuria	30.27	11.81	156	54248	49910	34852617
Red blood cells urine positive	30.25	11.81	24	54380	1785	34900742
Toxic epidermal necrolysis	30.21	11.81	88	54316	21558	34880969
Electrocardiogram ST segment elevation	30.21	11.81	39	54365	5199	34897328
Intestinal ischaemia	30.17	11.81	48	54356	7746	34894781
Pulmonary alveolar haemorrhage	30.10	11.81	47	54357	7465	34895062
Hypercoagulation	30.05	11.81	21	54383	1287	34901240
Anticoagulation drug level below therapeutic	29.97	11.81	18	54386	850	34901677
Cardiac procedure complication	29.84	11.81	11	54393	166	34902361
Cerebral reperfusion injury	29.74	11.81	6	54398	4	34902523
Burkholderia test positive	29.70	11.81	19	54385	1004	34901523
Heparin-induced thrombocytopenia test	29.67	11.81	10	54394	114	34902413
Hypertransaminasaemia	29.64	11.81	40	54364	5566	34896961
Brain oedema	29.52	11.81	66	54338	13755	34888772
Subdural haematoma	29.45	11.81	84	54320	20337	34882190
Injection site pain	29.27	11.81	12	54392	38993	34863534
Haemorrhagic stroke	29.15	11.81	43	54361	6496	34896031
Prosthetic cardiac valve thrombosis	29.11	11.81	7	54397	19	34902508
Reperfusion injury	29.01	11.81	9	54395	77	34902450
Tongue haematoma	28.77	11.81	10	54394	126	34902401
Loss of personal independence in daily activities	28.74	11.81	8	54396	33171	34869356
Rash	28.64	11.81	216	54188	222536	34679991
Feeling abnormal	28.32	11.81	34	54370	63201	34839326
Cerebral mass effect	27.91	11.81	18	54386	965	34901562
Gastrointestinal haemorrhage	27.86	11.81	234	54170	88243	34814284
Vasodilatation	27.65	11.81	19	54385	1133	34901394
Coronary artery perforation	27.57	11.81	8	54396	53	34902474
Peripheral artery occlusion	27.11	11.81	22	54382	1690	34900837
Prostate cancer	26.96	11.81	14	54390	39635	34862892
Acute myocardial infarction	26.86	11.81	159	54245	53560	34848967
Spinal epidural haematoma	26.72	11.81	12	54392	307	34902220
Pain in extremity	26.59	11.81	104	54300	126409	34776118
Drug hypersensitivity	26.44	11.81	215	54189	80314	34822213
Vascular graft thrombosis	26.36	11.81	10	54394	164	34902363
Arthritis	26.34	11.81	8	54396	31338	34871189
Neuropathy peripheral	25.82	11.81	57	54347	83206	34819321
Dyspnoea exertional	25.63	11.81	18	54386	43261	34859266
Leukocytosis	25.51	11.81	89	54315	23976	34878551
Acute right ventricular failure	25.50	11.81	9	54395	119	34902408
Obstructive shock	25.46	11.81	7	54397	37	34902490
Gastrointestinal necrosis	25.43	11.81	29	54375	3400	34899127
Device related thrombosis	25.27	11.81	18	54386	1137	34901390
Acute respiratory failure	25.06	11.81	105	54299	30823	34871704
Psychotic disorder	25.06	11.81	4	54400	24448	34878079
Aortic dissection	25.05	11.81	26	54378	2742	34899785
Product contamination	25.00	11.81	15	54389	707	34901820
Blood urea increased	24.54	11.81	103	54301	30261	34872266
Vena cava thrombosis	24.36	11.81	18	54386	1204	34901323
Oedema peripheral	24.23	11.81	100	54304	119712	34782815
Aneurysm ruptured	24.12	11.81	13	54391	498	34902029
Acute generalised exanthematous pustulosis	23.88	11.81	40	54364	6736	34895791
Abnormal behaviour	23.62	11.81	5	54399	24964	34877563
Peripheral swelling	23.24	11.81	53	54351	76488	34826039
Overdose	23.10	11.81	69	54335	90990	34811537
Blood uric acid increased	22.89	11.81	48	54356	9576	34892951
Platelet transfusion	22.89	11.81	19	54385	1507	34901020
Malignant neoplasm progression	22.86	11.81	66	54338	87980	34814547
Alopecia	22.79	11.81	5	54399	24350	34878177
Foetal growth restriction	22.73	11.81	30	54374	4087	34898440
Anxiety	22.68	11.81	79	54325	99349	34803178
Bronchial haemorrhage	22.67	11.81	14	54390	695	34901832
Device related sepsis	22.67	11.81	26	54378	3067	34899460
Vascular pseudoaneurysm	22.63	11.81	22	54382	2145	34900382
Haemoptysis	22.51	11.81	111	54293	34895	34867632
Dyspnoea	22.30	11.81	433	53971	376349	34526178
Osteoarthritis	22.02	11.81	3	54401	20639	34881888
Haemoperitoneum	22.00	11.81	20	54384	1792	34900735
Blood aldosterone decreased	21.87	11.81	4	54400	0	34902527
Ischaemic hepatitis	21.85	11.81	20	54384	1808	34900719
Dysgeusia	21.83	11.81	7	54397	26490	34876037
Bronchopulmonary aspergillosis	21.82	11.81	61	54343	14598	34887929
Activated partial thromboplastin time shortened	21.77	11.81	12	54392	481	34902046
Antiphospholipid syndrome	21.59	11.81	12	54392	489	34902038
Hepatic cytolysis	21.26	11.81	60	54344	14436	34888091
Cognitive disorder	21.25	11.81	9	54395	28684	34873843
Bullous haemorrhagic dermatosis	21.24	11.81	5	54399	12	34902515
Shock	21.10	11.81	84	54320	24095	34878432
Incorrect drug administration rate	21.06	11.81	19	54385	1686	34900841
Rash morbilliform	21.04	11.81	25	54379	3062	34899465
Epistaxis	21.03	11.81	159	54245	58092	34844435
Embolic stroke	20.89	11.81	30	54374	4424	34898103
Herpes zoster	20.77	11.81	14	54390	34385	34868142
Extradural haematoma	20.37	11.81	16	54388	1173	34901354
Unresponsive to stimuli	20.35	11.81	91	54313	27478	34875049
Blood pressure fluctuation	20.23	11.81	7	54397	25242	34877285
Foetal exposure timing unspecified	20.05	11.81	9	54395	230	34902297
Haemorrhagic cerebral infarction	20.05	11.81	14	54390	857	34901670
Nasopharyngitis	20.01	11.81	50	54354	69918	34832609
Encephalopathy	19.94	11.81	108	54296	35211	34867316
Foetal exposure during pregnancy	19.84	11.81	114	54290	37987	34864540
Ischaemic stroke	19.78	11.81	68	54336	18182	34884345
Visual impairment	19.77	11.81	16	54388	35786	34866741
Agitation	19.74	11.81	37	54367	57362	34845165
Gastric haemorrhage	19.71	11.81	47	54357	10214	34892313
Blood loss anaemia	19.64	11.81	41	54363	8153	34894374
Pulmonary artery thrombosis	19.53	11.81	13	54391	735	34901792
Anticoagulation drug level above therapeutic	19.37	11.81	20	54384	2096	34900431
Confusional state	19.36	11.81	138	54266	144022	34758505
COVID-19 pneumonia	19.08	11.81	64	54340	16903	34885624
Mediastinal haematoma	19.03	11.81	7	54397	105	34902422
Treatment noncompliance	18.99	11.81	10	54394	28090	34874437
Vascular access site haemorrhage	18.94	11.81	5	54399	22	34902505
Vertigo	18.93	11.81	8	54396	25528	34876999
Intrapericardial thrombosis	18.78	11.81	6	54398	57	34902470
Hyponatraemia	18.73	11.81	204	54200	82487	34820040
Respiratory tract oedema	18.72	11.81	10	54394	376	34902151
Vascular access site haematoma	18.63	11.81	4	54400	5	34902522
Melaena	18.51	11.81	106	54298	35274	34867253
Hot flush	18.41	11.81	3	54401	18063	34884464
Livedo reticularis	18.36	11.81	20	54384	2229	34900298
Subcutaneous haematoma	18.32	11.81	14	54390	985	34901542
Medical device site thrombosis	18.25	11.81	5	54399	26	34902501
Peliosis hepatis	18.25	11.81	6	54398	63	34902464
Paraesthesia	18.24	11.81	46	54358	64126	34838401
Hyperphosphataemia	18.11	11.81	28	54376	4409	34898118
Suspected transmission of an infectious agent via product	18.06	11.81	13	54391	835	34901692
Hemiplegia	18.03	11.81	36	54368	6936	34895591
Graft thrombosis	17.98	11.81	9	54395	295	34902232
Upper gastrointestinal haemorrhage	17.91	11.81	83	54321	25435	34877092
Hallucination	17.89	11.81	33	54371	51465	34851062
Irritability	17.88	11.81	8	54396	24682	34877845
Therapeutic product effect increased	17.68	11.81	12	54392	701	34901826
Hypovolaemic shock	17.63	11.81	36	54368	7049	34895478
Thrombotic microangiopathy	17.59	11.81	46	54358	10584	34891943
Wrong technique in product usage process	17.59	11.81	18	54386	35968	34866559
Serratia infection	17.47	11.81	13	54391	879	34901648
Vision blurred	17.29	11.81	28	54376	45935	34856592
Hypoxia	16.95	11.81	145	54259	54950	34847577
Serratia sepsis	16.75	11.81	6	54398	83	34902444
Blood pressure decreased	16.61	11.81	137	54267	51378	34851149
Procedural pain	16.44	11.81	28	54376	4778	34897749
Anisochromia	16.40	11.81	3	54401	0	34902527
Acquired antithrombin III deficiency	16.40	11.81	3	54401	0	34902527
Full blood count decreased	16.35	11.81	4	54400	18084	34884443
Mean cell haemoglobin concentration	16.30	11.81	5	54399	41	34902486
Ventricular asystole	16.23	11.81	7	54397	162	34902365
Respiratory distress	16.21	11.81	103	54301	35562	34866965
Abdominal wall haematoma	16.17	11.81	17	54387	1820	34900707
Therapeutic product effect incomplete	16.16	11.81	34	54370	50507	34852020
Pancreatic haemorrhage	16.09	11.81	5	54399	43	34902484
Iliac artery occlusion	16.08	11.81	7	54397	166	34902361
Coronary artery aneurysm	16.07	11.81	6	54398	94	34902433
Disease progression	15.73	11.81	101	54303	107976	34794551
Diabetes insipidus	15.65	11.81	21	54383	2907	34899620
Hemiparesis	15.57	11.81	57	54347	15721	34886806
Brain death	15.51	11.81	20	54384	2663	34899864
Road traffic accident	15.50	11.81	4	54400	17446	34885081
Urea renal clearance decreased	15.46	11.81	4	54400	16	34902511
Tremor	15.42	11.81	71	54333	82516	34820011
Intestinal infarction	15.36	11.81	10	54394	545	34901982
Gastrooesophageal reflux disease	15.32	11.81	22	54382	37902	34864625
Neutrophil count increased	15.31	11.81	60	54344	17086	34885441
Drug ineffective for unapproved indication	15.10	11.81	75	54329	23640	34878887
Femoral nerve palsy	14.84	11.81	5	54399	57	34902470
Basal cell carcinoma	14.83	11.81	6	54398	19652	34882875
Nutritional condition abnormal	14.77	11.81	9	54395	436	34902091
Tachycardia	14.77	11.81	199	54205	84573	34817954
Gangrene	14.75	11.81	26	54378	4560	34897967
Protein urine present	14.74	11.81	28	54376	5200	34897327
Alveolitis necrotising	14.73	11.81	4	54400	20	34902507
Cardiac disorder	14.65	11.81	28	54376	43098	34859429
Syncope	14.60	11.81	83	54321	91368	34811159
Food interaction	14.57	11.81	12	54392	941	34901586
Monoplegia	14.55	11.81	15	54389	1569	34900958
Amnesia	14.51	11.81	12	54392	26551	34875976
Hepatic infarction	14.50	11.81	7	54397	212	34902315
Drug intolerance	14.49	11.81	46	54358	59524	34843003
Intra-abdominal haematoma	14.48	11.81	14	54390	1356	34901171
Splenic infarction	14.47	11.81	17	54387	2058	34900469
Neonatal respiratory distress syndrome	14.46	11.81	24	54380	4010	34898517
Mixed liver injury	14.44	11.81	20	54384	2853	34899674
Haemostasis	14.32	11.81	6	54398	129	34902398
Cholestasis	14.27	11.81	81	54323	26867	34875660
Osteonecrosis of jaw	14.26	11.81	5	54399	17884	34884643
Retinal pigment epitheliopathy	14.17	11.81	7	54397	223	34902304
Therapeutic product ineffective	14.16	11.81	11	54393	793	34901734
Ventricular extrasystoles	14.13	11.81	46	54358	11962	34890565
Reperfusion arrhythmia	14.10	11.81	5	54399	67	34902460
Cataract	14.09	11.81	12	54392	26174	34876353
Analgesic therapy	14.09	11.81	12	54392	986	34901541
White blood cell count decreased	13.99	11.81	89	54315	95356	34807171
Bladder cancer	13.96	11.81	4	54400	16274	34886253
Orthostatic hypotension	13.80	11.81	12	54392	25907	34876620
Prostatic specific antigen increased	13.76	11.81	3	54401	14677	34887850
Renal haemorrhage	13.75	11.81	14	54390	1443	34901084
Drug ineffective	13.72	11.81	854	53550	455897	34446630
Inferior vena caval occlusion	13.59	11.81	4	54400	28	34902499
Immune thrombocytopenia	13.54	11.81	38	54366	9114	34893413
Platelet disorder	13.52	11.81	15	54389	1706	34900821
Hydrocephalus	13.51	11.81	27	54377	5205	34897322
Drug withdrawal syndrome	13.49	11.81	7	54397	19827	34882700
Protein C decreased	13.47	11.81	4	54400	29	34902498
Skin ulcer	13.47	11.81	9	54395	22207	34880320
Fungal sepsis	13.47	11.81	11	54393	853	34901674
Cerebral haematoma	13.37	11.81	25	54379	4590	34897937
Apgar score abnormal	13.36	11.81	4	54400	30	34902497
Incorrect route of product administration	13.30	11.81	52	54352	14793	34887734
Microstomia	13.12	11.81	3	54401	6	34902521
Hospitalisation	13.11	11.81	45	54359	56857	34845670
Aplastic anaemia	13.08	11.81	39	54365	9677	34892850
Hepatic artery occlusion	13.07	11.81	5	54399	84	34902443
Influenza	13.05	11.81	37	54367	49629	34852898
Erectile dysfunction	13.00	11.81	8	54396	20629	34881898
Iron deficiency	12.99	11.81	27	54377	5354	34897173
Microangiopathic haemolytic anaemia	12.95	11.81	11	54393	901	34901626
Catheter site haematoma	12.93	11.81	6	54398	166	34902361
Anaphylactoid reaction	12.92	11.81	17	54387	2308	34900219
Myiasis	12.92	11.81	4	54400	34	34902493
Necrotising oesophagitis	12.80	11.81	9	54395	557	34901970
Drug therapy	12.71	11.81	12	54392	1129	34901398
Haemorrhagic cholecystitis	12.70	11.81	5	54399	91	34902436
Sleep apnoea syndrome	12.64	11.81	8	54396	20313	34882214
Myocardial rupture	12.63	11.81	6	54398	175	34902352
Thrombectomy	12.60	11.81	5	54399	93	34902434
Mental disorder	12.56	11.81	4	54400	15205	34887322
Dermatitis bullous	12.54	11.81	31	54373	6891	34895636
Incision site haematoma	12.41	11.81	5	54399	97	34902430
Tinnitus	12.40	11.81	8	54396	20110	34882417
Rhinorrhoea	12.36	11.81	13	54391	25655	34876872
Flatulence	12.31	11.81	9	54395	21189	34881338
Blindness	12.27	11.81	4	54400	14982	34887545
Anti factor Xa activity decreased	12.26	11.81	3	54401	9	34902518
No adverse event	12.20	11.81	69	54335	22858	34879669
Pneumonia escherichia	12.19	11.81	8	54396	442	34902085
Platelet aggregation test	12.16	11.81	4	54400	42	34902485
Renal artery thrombosis	12.10	11.81	7	54397	308	34902219
Lumbar puncture	12.09	11.81	5	54399	104	34902423
Visual acuity reduced	12.06	11.81	5	54399	16144	34886383
Cough	12.01	11.81	163	54241	149977	34752550
Infusion site extravasation	11.92	11.81	23	54381	4321	34898206
Type 2 diabetes mellitus	11.92	11.81	5	54399	16027	34886500
Palpitations	11.88	11.81	28	54376	39958	34862569
Sleep disorder therapy	11.85	11.81	11	54393	1012	34901515
Respiratory gas exchange disorder	11.84	11.81	8	54396	464	34902063
Dry mouth	11.83	11.81	84	54320	30081	34872446

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Heparin-induced thrombocytopenia	6087.45	10.78	1560	95400	8122	79639306
Vascular stent thrombosis	547.94	10.78	196	96764	3514	79643914
Thrombocytopenia	494.60	10.78	1033	95927	264226	79383202
Haemorrhage	408.14	10.78	528	96432	90590	79556838
Labelled drug-drug interaction medication error	390.59	10.78	300	96660	27350	79620078
Haematoma	382.13	10.78	390	96570	51805	79595623
Shock haemorrhagic	375.23	10.78	258	96702	19802	79627626
Multiple organ dysfunction syndrome	369.20	10.78	582	96378	119664	79527764
Cardiogenic shock	358.57	10.78	341	96619	41573	79605855
Premature delivery	347.74	10.78	262	96698	23205	79624223
Cerebral haemorrhage	311.00	10.78	367	96593	57306	79590122
Thrombosis	304.94	10.78	440	96520	83660	79563768
Retroperitoneal haematoma	303.77	10.78	142	96818	5155	79642273
Haemorrhage intracranial	289.00	10.78	246	96714	25947	79621481
Pulmonary embolism	284.56	10.78	638	96322	171016	79476412
Arthralgia	260.09	10.78	190	96770	571613	79075815
Retroperitoneal haemorrhage	257.26	10.78	128	96832	5342	79642086
Completed suicide	255.28	10.78	10	96950	245757	79401671
Joint swelling	242.85	10.78	32	96928	288614	79358814
Thrombosis in device	240.24	10.78	122	96838	5320	79642108
Appendicolith	234.50	10.78	140	96820	8411	79639017
Ventricular fibrillation	223.58	10.78	233	96727	31693	79615735
Fatigue	219.74	10.78	506	96454	929221	78718207
Sepsis	217.52	10.78	771	96189	268657	79378771
Rheumatoid arthritis	208.27	10.78	11	96949	208459	79438969
Cardiac tamponade	204.06	10.78	132	96828	9144	79638284
Pain	200.52	10.78	343	96617	703459	78943969
Acute kidney injury	197.09	10.78	1190	95770	518214	79129214
Activated partial thromboplastin time prolonged	195.72	10.78	152	96808	14076	79633352
Post procedural haemorrhage	185.09	10.78	145	96815	13599	79633829
Haemothorax	183.04	10.78	102	96858	5376	79642052
Heparin resistance	178.37	10.78	36	96924	41	79647387
Haematoma muscle	174.81	10.78	78	96882	2537	79644891
Cerebral infarction	172.87	10.78	244	96716	45432	79601996
Arthropathy	168.91	10.78	12	96948	177099	79470329
Appendicitis	166.15	10.78	163	96797	20631	79626797
Drug intolerance	165.96	10.78	57	96903	264062	79383366
Alopecia	163.58	10.78	40	96920	231315	79416113
Maternal exposure during pregnancy	161.18	10.78	446	96514	136092	79511336
Cardiac arrest	160.38	10.78	517	96443	171579	79475849
Arterial thrombosis	151.21	10.78	71	96889	2603	79644825
Off label use	150.94	10.78	1724	95236	905491	78741937
Exposure during pregnancy	149.97	10.78	360	96600	100772	79546656
Drug abuse	149.60	10.78	13	96947	162678	79484750
Coagulation time shortened	144.53	10.78	42	96918	370	79647058
Compartment syndrome	144.04	10.78	85	96875	4997	79642431
Septic shock	142.82	10.78	399	96561	122402	79525026
Deep vein thrombosis	142.72	10.78	395	96565	120524	79526904
Toxicity to various agents	140.60	10.78	184	96776	421356	79226072
Coagulation time prolonged	137.25	10.78	65	96895	2430	79644998
Abdominal wall haematoma	134.18	10.78	80	96880	4793	79642635
Pharyngeal haemorrhage	134.13	10.78	53	96907	1263	79646165
Abdominal discomfort	133.63	10.78	69	96891	250658	79396770
Disseminated intravascular coagulation	130.52	10.78	188	96772	35654	79611774
Heparin-induced thrombocytopenia test positive	129.87	10.78	31	96929	112	79647316
Eosinophilia	128.79	10.78	212	96748	45133	79602295
Haemoglobin decreased	128.56	10.78	573	96387	221546	79425882
Brain herniation	127.90	10.78	91	96869	7372	79640056
Respiratory failure	126.84	10.78	495	96465	180416	79467012
Muscle haemorrhage	124.85	10.78	84	96876	6216	79641212
Product use in unapproved indication	118.90	10.78	610	96350	249749	79397679
Venous thrombosis	117.89	10.78	85	96875	7031	79640397
Subarachnoid haemorrhage	117.68	10.78	147	96813	24318	79623110
Vascular pseudoaneurysm	113.59	10.78	64	96896	3446	79643982
Drug reaction with eosinophilia and systemic symptoms	112.17	10.78	244	96716	64000	79583428
Coagulopathy	111.35	10.78	175	96785	35831	79611597
Blood phosphorus increased	109.68	10.78	95	96865	10252	79637176
Spinal epidural haematoma	109.65	10.78	47	96913	1385	79646043
Weight increased	108.86	10.78	106	96854	277280	79370148
Extradural haematoma	108.41	10.78	58	96902	2818	79644610
Hereditary angioedema	107.81	10.78	72	96888	5263	79642165
Intracardiac thrombus	106.69	10.78	66	96894	4227	79643201
Toxic epidermal necrolysis	106.40	10.78	193	96767	44388	79603040
Musculoskeletal stiffness	106.09	10.78	40	96920	174968	79472460
Pericardial haemorrhage	103.91	10.78	66	96894	4429	79642999
Procedural haemorrhage	103.59	10.78	67	96893	4639	79642789
Pemphigus	103.51	10.78	4	96956	99578	79547850
Catheter site haemorrhage	103.26	10.78	69	96891	5048	79642380
Dizziness	102.29	10.78	315	96645	526126	79121302
Malaise	101.79	10.78	284	96676	489585	79157843
Subdural haematoma	98.90	10.78	154	96806	31280	79616148
Coronary artery thrombosis	98.80	10.78	56	96904	3050	79644378
Peripheral ischaemia	98.57	10.78	86	96874	9371	79638057
Haemoperitoneum	98.48	10.78	63	96897	4280	79643148
Weight decreased	98.23	10.78	176	96784	355022	79292406
Aplastic anaemia	96.56	10.78	114	96846	17791	79629637
Intentional overdose	95.96	10.78	9	96951	105951	79541477
Hypotension	95.83	10.78	885	96075	439432	79207996
Diarrhoea	95.16	10.78	654	96306	879835	78767593
Rash maculo-papular	94.52	10.78	210	96750	55868	79591560
Depression	93.26	10.78	76	96884	216714	79430714
Peripheral artery thrombosis	92.84	10.78	56	96904	3427	79644001
Haemodynamic instability	92.63	10.78	110	96850	17272	79630156
Intraventricular haemorrhage	91.71	10.78	63	96897	4824	79642604
Cardiac ventricular thrombosis	90.87	10.78	44	96916	1729	79645699
Arthritis	89.09	10.78	16	96944	114864	79532564
Intra-abdominal haemorrhage	88.69	10.78	60	96900	4480	79642948
Embolism	87.22	10.78	96	96864	13886	79633542
Wound	86.26	10.78	18	96942	116161	79531267
Systemic lupus erythematosus	85.48	10.78	21	96939	121128	79526300
Insomnia	84.78	10.78	104	96856	245066	79402362
Nasopharyngitis	84.36	10.78	111	96849	253770	79393658
Choroidal infarction	83.78	10.78	23	96937	161	79647267
Adrenal haemorrhage	81.27	10.78	30	96930	590	79646838
Pulseless electrical activity	79.43	10.78	92	96868	14068	79633360
Gastrointestinal haemorrhage	79.39	10.78	373	96587	147346	79500082
Psoriatic arthropathy	78.22	10.78	4	96956	77995	79569433
Coagulation time	77.28	10.78	14	96946	3	79647425
Injection site pain	76.49	10.78	31	96929	129807	79517621
Acute myocardial infarction	75.86	10.78	236	96724	76800	79570628
Pulmonary alveolar haemorrhage	75.54	10.78	81	96879	11376	79636052
Suicide attempt	75.21	10.78	7	96953	82925	79564503
Skin necrosis	74.99	10.78	101	96859	17986	79629442
Acute respiratory distress syndrome	74.23	10.78	165	96795	43902	79603526
Peripheral swelling	74.14	10.78	134	96826	269483	79377945
Haemorrhagic transformation stroke	73.61	10.78	44	96916	2648	79644780
Psoriasis	72.76	10.78	11	96949	89576	79557852
Product administration error	72.37	10.78	135	96825	31711	79615717
Mobility decreased	72.25	10.78	29	96931	122146	79525282
Aortic thrombosis	71.91	10.78	37	96923	1658	79645770
Lower respiratory tract infection	71.15	10.78	34	96926	129186	79518242
Haematuria	70.68	10.78	214	96746	68622	79578806
Atrial thrombosis	70.66	10.78	48	96912	3608	79643820
Encephalopathy	70.59	10.78	211	96749	67186	79580242
Suicidal ideation	70.43	10.78	6	96954	76334	79571094
Arterial haemorrhage	70.40	10.78	42	96918	2519	79644909
Memory impairment	70.32	10.78	24	96936	111710	79535718
Pericarditis	69.87	10.78	20	96940	104216	79543212
Rash	68.20	10.78	418	96542	577940	79069488
Loss of personal independence in daily activities	68.17	10.78	20	96940	102560	79544868
Pulmonary haemorrhage	66.93	10.78	86	96874	14631	79632797
Gait disturbance	66.62	10.78	93	96867	207413	79440015
Asthma	66.44	10.78	41	96919	135054	79512374
Hypersensitivity	65.45	10.78	138	96822	262101	79385327
Osteoarthritis	63.84	10.78	14	96946	87295	79560133
Hypoxia	63.19	10.78	271	96689	102972	79544456
Ascites	62.32	10.78	218	96742	75344	79572084
Hypercoagulation	61.85	10.78	41	96919	2959	79644469
Coagulation time abnormal	61.60	10.78	19	96941	209	79647219
Decreased appetite	61.47	10.78	212	96748	342206	79305222
Shock	61.29	10.78	152	96808	43396	79604032
Haemorrhagic infarction	61.23	10.78	26	96934	748	79646680
Blood pressure decreased	60.81	10.78	261	96699	99205	79548223
Impaired healing	60.28	10.78	16	96944	87639	79559789
Fall	59.79	10.78	348	96612	487281	79160147
Ischaemic stroke	59.15	10.78	127	96833	33004	79614424
Vena cava thrombosis	58.33	10.78	39	96921	2856	79644572
Headache	57.65	10.78	513	96447	653259	78994169
Autoimmune heparin-induced thrombocytopenia	57.59	10.78	12	96948	18	79647410
Asthenia	57.12	10.78	376	96584	511313	79136115
Puncture site haemorrhage	56.55	10.78	23	96937	592	79646836
Ventricular tachycardia	56.54	10.78	144	96816	41791	79605637
Cerebral haematoma	55.65	10.78	58	96902	7884	79639544
Anticoagulation drug level below therapeutic	55.22	10.78	30	96930	1503	79645925
Acute generalised exanthematous pustulosis	54.93	10.78	85	96875	17169	79630259
Myalgia	54.92	10.78	88	96872	185553	79461875
Product measured potency issue	54.87	10.78	17	96943	190	79647238
Antiphospholipid syndrome	54.57	10.78	32	96928	1859	79645569
Irritable bowel syndrome	54.50	10.78	6	96954	62235	79585193
Pain in extremity	53.79	10.78	244	96716	364294	79283134
Renal infarct	53.61	10.78	36	96924	2655	79644773
Discomfort	52.80	10.78	45	96915	125572	79521856
Vasodilatation	52.59	10.78	38	96922	3153	79644275
Swelling	51.62	10.78	117	96843	216594	79430834
Electrocardiogram ST segment elevation	51.24	10.78	57	96903	8340	79639088
Anaemia	51.15	10.78	792	96168	444223	79203205
Blood pressure fluctuation	50.67	10.78	10	96950	67135	79580293
Anxiety	50.09	10.78	146	96814	248366	79399062
Hepatic enzyme increased	49.95	10.78	91	96869	182519	79464909
Muscle spasms	49.67	10.78	85	96875	174645	79472783
Respiratory distress	49.57	10.78	170	96790	58169	79589259
Oesophageal intramural haematoma	49.48	10.78	14	96946	111	79647317
Stevens-Johnson syndrome	49.22	10.78	131	96829	39035	79608393
Thrombotic microangiopathy	48.98	10.78	88	96872	20081	79627347
Coronary artery perforation	48.93	10.78	13	96947	79	79647349
Hyperkalaemia	48.93	10.78	271	96689	114127	79533301
Acute respiratory failure	47.57	10.78	170	96790	59371	79588057
Incision site pain	47.33	10.78	34	96926	2796	79644632
Mixed liver injury	47.21	10.78	52	96908	7526	79639902
Therapeutic product effect incomplete	46.94	10.78	62	96898	141583	79505845
C-reactive protein abnormal	46.90	10.78	3	96957	48364	79599064
Haemoptysis	46.55	10.78	162	96798	55837	79591591
Haemorrhagic stroke	46.28	10.78	62	96898	10984	79636444
Intestinal ischaemia	45.97	10.78	68	96892	13202	79634226
Subchorionic haematoma	45.95	10.78	13	96947	103	79647325
Peripheral artery occlusion	45.72	10.78	32	96928	2525	79644903
Ill-defined disorder	45.34	10.78	12	96948	65863	79581565
Brain oedema	45.28	10.78	97	96863	25166	79622262
Platelet count decreased	45.15	10.78	397	96563	194267	79453161
Gangrene	44.94	10.78	55	96905	8909	79638519
Feeling abnormal	44.74	10.78	78	96882	159121	79488307
Pulmonary infarction	44.19	10.78	37	96923	3812	79643616
Vascular stent occlusion	44.15	10.78	15	96945	229	79647199
Anticoagulation drug level above therapeutic	44.06	10.78	36	96924	3584	79643844
Suspected product quality issue	44.00	10.78	16	96944	301	79647127
Cerebral reperfusion injury	43.82	10.78	10	96950	28	79647400
Product contamination	43.57	10.78	24	96936	1236	79646192
Product quality issue	43.13	10.78	114	96846	33826	79613602
Infective aneurysm	42.76	10.78	22	96938	986	79646442
Confusional state	42.74	10.78	220	96740	317777	79329651
Treatment failure	42.27	10.78	90	96870	170396	79477032
Heparin-induced thrombocytopenia test	41.90	10.78	13	96947	146	79647282
Cerebral venous sinus thrombosis	41.73	10.78	29	96931	2262	79645166
Foetal death	41.37	10.78	50	96910	7994	79639434
Melaena	41.31	10.78	165	96795	60725	79586703
Renal failure	41.13	10.78	399	96561	200569	79446859
Knee arthroplasty	41.01	10.78	3	96957	43245	79604183
Balance disorder	40.83	10.78	36	96924	98821	79548607
Hemiparesis	40.55	10.78	111	96849	33622	79613806
Vascular access site haemorrhage	40.51	10.78	10	96950	43	79647385
Splenic rupture	40.20	10.78	29	96931	2400	79645028
Fibromyalgia	40.16	10.78	14	96946	64326	79583102
Injection site swelling	40.13	10.78	5	96955	47127	79600301
Product dose omission issue	39.98	10.78	160	96800	247377	79400051
Epistaxis	39.85	10.78	252	96708	111263	79536165
Gastrointestinal necrosis	39.64	10.78	41	96919	5524	79641904
Blood urea increased	39.57	10.78	140	96820	48650	79598778
Acute motor-sensory axonal neuropathy	39.30	10.78	16	96944	413	79647015
Device related sepsis	39.19	10.78	43	96917	6197	79641231
Obstructive shock	39.01	10.78	11	96949	86	79647342
Jugular vein thrombosis	38.93	10.78	37	96923	4501	79642927
Venoocclusive liver disease	38.89	10.78	59	96901	11712	79635716
Lymphocyte count decreased	38.61	10.78	136	96824	47153	79600275
Blood loss anaemia	38.12	10.78	68	96892	15430	79631998
Anti factor Xa activity decreased	38.00	10.78	8	96952	13	79647415
Inflammation	37.70	10.78	35	96925	93718	79553710
Splenic infarction	37.54	10.78	33	96927	3631	79643797
Dry gangrene	37.43	10.78	20	96940	969	79646459
Injury	37.43	10.78	24	96936	77472	79569956
Tongue haematoma	37.08	10.78	13	96947	219	79647209
Medical device site thrombosis	36.98	10.78	9	96951	36	79647392
Cholestasis	36.80	10.78	143	96817	51966	79595462
Incorrect drug administration rate	36.80	10.78	34	96926	3992	79643436
Spinal subdural haematoma	36.70	10.78	13	96947	226	79647202
Suspected transmission of an infectious agent via product	36.69	10.78	21	96939	1165	79646263
Serratia infection	35.96	10.78	24	96936	1752	79645676
Hypervolaemia	35.92	10.78	124	96836	42566	79604862
Hydrocephalus	35.83	10.78	49	96911	8851	79638577
Orbital compartment syndrome	35.83	10.78	10	96950	75	79647353
Intra-abdominal haematoma	35.72	10.78	29	96931	2862	79644566
Cerebral hyperperfusion syndrome	35.66	10.78	11	96949	121	79647307
Myasthenia gravis	35.61	10.78	53	96907	10346	79637082
Leukocytosis	35.50	10.78	125	96835	43330	79604098
Brain death	35.44	10.78	39	96921	5638	79641790
Chest wall haematoma	35.25	10.78	15	96945	434	79646994
Type 2 diabetes mellitus	34.69	10.78	13	96947	57109	79590319
Cerebral mass effect	34.42	10.78	24	96936	1882	79645546
Platelet transfusion	34.35	10.78	26	96934	2316	79645112
Bullous haemorrhagic dermatosis	34.22	10.78	10	96950	90	79647338
Abdominal distension	34.22	10.78	256	96704	119394	79528034
Vascular graft occlusion	34.13	10.78	17	96943	711	79646717
Cardiac procedure complication	34.01	10.78	14	96946	372	79647056
Prosthetic cardiac valve thrombosis	33.97	10.78	9	96951	54	79647374
Vascular graft thrombosis	33.70	10.78	12	96948	212	79647216
Platelet aggregation inhibition	33.58	10.78	11	96949	149	79647279
Ocular retrobulbar haemorrhage	33.45	10.78	11	96949	151	79647277
Cerebellar haemorrhage	33.38	10.78	28	96932	2892	79644536
Drug ineffective for unapproved indication	33.29	10.78	137	96823	51101	79596327
Blood creatinine increased	33.27	10.78	311	96649	154746	79492682
Injection site erythema	32.87	10.78	28	96932	78169	79569259
Iliac artery occlusion	32.73	10.78	13	96947	314	79647114
Red blood cells urine positive	32.56	10.78	35	96925	4928	79642500
Haemorrhagic cerebral infarction	32.41	10.78	21	96939	1458	79645970
Hemiplegia	32.29	10.78	62	96898	14877	79632551
Gastrooesophageal reflux disease	32.17	10.78	48	96912	104198	79543230
Death	31.80	10.78	491	96469	566023	79081405
Abdominal pain upper	31.68	10.78	152	96808	223667	79423761
Protein C decreased	31.41	10.78	9	96951	75	79647353
Folliculitis	31.36	10.78	14	96946	55366	79592062
Infusion related reaction	31.08	10.78	159	96801	230078	79417350
Rhinorrhoea	31.06	10.78	28	96932	76046	79571382
Premature rupture of membranes	30.84	10.78	31	96929	4038	79643390
Dyspepsia	30.76	10.78	53	96907	108634	79538794
Activated partial thromboplastin time shortened	30.75	10.78	17	96943	882	79646546
Gastrointestinal disorder	30.72	10.78	64	96896	122141	79525287
Cognitive disorder	30.69	10.78	24	96936	69902	79577526
Transfusion	30.59	10.78	75	96885	21255	79626173
No adverse event	30.40	10.78	107	96853	37085	79610343
Wheezing	30.26	10.78	60	96900	116604	79530824
Embolic cerebral infarction	30.22	10.78	19	96941	1252	79646176
Subcapsular renal haematoma	30.22	10.78	16	96944	761	79646667
Dysgeusia	30.03	10.78	16	96944	57161	79590267
Influenza	30.02	10.78	71	96889	129535	79517893
Adverse event	29.98	10.78	18	96942	60196	79587232
Sinusitis	29.92	10.78	129	96831	195372	79452056
COVID-19 pneumonia	29.90	10.78	90	96870	28759	79618669
Embolic stroke	29.88	10.78	42	96918	7784	79639644
Visual impairment	29.84	10.78	41	96919	92090	79555338
Ischaemic hepatitis	29.78	10.78	29	96931	3635	79643793
Oliguria	29.66	10.78	63	96897	16246	79631182
Cardiac valve replacement complication	29.63	10.78	11	96949	220	79647208
Upper gastrointestinal haemorrhage	29.58	10.78	114	96846	41266	79606162
Bronchial haemorrhage	29.56	10.78	19	96941	1301	79646127
Psychotic disorder	29.54	10.78	7	96953	41395	79606033
Tachypnoea	29.51	10.78	96	96864	31967	79615461
Hot flush	29.35	10.78	15	96945	54862	79592566
Procedural complication	29.24	10.78	42	96918	7941	79639487
Device related thrombosis	29.18	10.78	25	96935	2658	79644770
Paraesthesia	29.08	10.78	113	96847	176210	79471218
Drug dependence	28.88	10.78	7	96953	40762	79606666
Anti-platelet antibody	28.79	10.78	6	96954	9	79647419
Graft thrombosis	28.73	10.78	13	96947	437	79646991
Procedural hypotension	28.66	10.78	22	96938	2001	79645427
Pulmonary artery thrombosis	28.64	10.78	19	96941	1373	79646055
Atrial fibrillation	28.64	10.78	367	96593	197519	79449909
Abdominal compartment syndrome	28.59	10.78	20	96940	1577	79645851
Injection site pruritus	28.54	10.78	8	96952	42275	79605153
Back pain	28.37	10.78	235	96725	303945	79343483
Fungal sepsis	28.37	10.78	21	96939	1809	79645619
Spontaneous haematoma	28.27	10.78	19	96941	1403	79646025
Immune thrombocytopenia	28.12	10.78	65	96895	17740	79629688
Injection site reaction	27.81	10.78	16	96944	54769	79592659
Hepatic infarction	27.77	10.78	16	96944	899	79646529
Rectosigmoid cancer	27.46	10.78	11	96949	272	79647156
Blood albumin decreased	27.39	10.78	78	96882	24165	79623263
Reperfusion injury	27.36	10.78	10	96950	191	79647237
Pulmonary haematoma	27.34	10.78	9	96951	124	79647304
Aggression	27.15	10.78	14	96946	50944	79596484
Toxoplasmosis	27.05	10.78	24	96936	2673	79644755
Spinal cord compression	27.03	10.78	36	96924	6341	79641087
Sopor	26.92	10.78	4	96956	33006	79614422
Coagulation test abnormal	26.81	10.78	18	96942	1327	79646101
Pituitary apoplexy	26.80	10.78	10	96950	203	79647225
Arterial intramural haematoma	26.71	10.78	8	96952	79	79647349
Tachycardia	26.70	10.78	332	96628	177436	79469992
Aortic dissection	26.62	10.78	29	96931	4146	79643282
Therapeutic product effect increased	26.56	10.78	19	96941	1552	79645876
Rash morbilliform	26.50	10.78	35	96925	6115	79641313
Hypertransaminasaemia	26.41	10.78	50	96910	11874	79635554
Infection	26.21	10.78	179	96781	241533	79405895
Gait inability	26.13	10.78	20	96940	58897	79588531
Diabetes insipidus	26.04	10.78	32	96928	5205	79642223
Ischaemia	26.01	10.78	40	96920	8035	79639393
Hepatic haematoma	25.98	10.78	15	96945	846	79646582
Dermatitis bullous	25.88	10.78	55	96905	14190	79633238
Unresponsive to stimuli	25.77	10.78	135	96825	55653	79591775
Pericardial effusion	25.73	10.78	118	96842	46119	79601309
Pulse absent	25.72	10.78	45	96915	10058	79637370
Cerebral artery embolism	25.56	10.78	20	96940	1871	79645557
Stomatitis	25.53	10.78	92	96868	146665	79500763
Ventricle rupture	25.46	10.78	8	96952	94	79647334
Stress	25.46	10.78	175	96785	79437	79567991
Night sweats	25.34	10.78	16	96944	52079	79595349
Paraplegia	25.32	10.78	31	96929	5022	79642406
Neutrophil count increased	25.27	10.78	86	96874	29310	79618118
Gastric haemorrhage	24.94	10.78	56	96904	14994	79632434
Herpes zoster	24.90	10.78	47	96913	93036	79554392
Wrong technique in product usage process	24.81	10.78	32	96928	73843	79573585
Renal haemorrhage	24.49	10.78	21	96939	2235	79645193
Hypovolaemic shock	24.18	10.78	49	96911	12227	79635201
Normal newborn	24.15	10.78	36	96924	7036	79640392
Intentional self-injury	24.10	10.78	5	96955	32414	79615014
Heart rate decreased	24.09	10.78	30	96930	70286	79577142
Drug chemical incompatibility	24.05	10.78	8	96952	114	79647314
Mucosal erosion	24.00	10.78	21	96939	2297	79645131
Red blood cell sedimentation rate increased	23.92	10.78	13	96947	45929	79601499
Blood pressure systolic increased	23.57	10.78	28	96932	66958	79580470
Caesarean section	23.47	10.78	49	96911	12486	79634942
Nervous system disorder	23.46	10.78	79	96881	26777	79620651
Purpura	23.21	10.78	64	96896	19463	79627965
Adverse drug reaction	23.09	10.78	28	96932	66364	79581064
Mediastinal haematoma	22.95	10.78	9	96951	210	79647218
Cataract	22.90	10.78	25	96935	62095	79585333
Acquired antithrombin III deficiency	22.85	10.78	4	96956	0	79647428
Spontaneous heparin-induced thrombocytopenia syndrome	22.85	10.78	4	96956	0	79647428
Bleeding time prolonged	22.83	10.78	16	96944	1265	79646163
Pruritus	22.81	10.78	340	96620	394308	79253120
Subcutaneous haematoma	22.61	10.78	22	96938	2755	79644673
Amnesia	22.57	10.78	26	96934	63031	79584397
Dyspnoea	22.53	10.78	834	96126	856191	78791237
Femoral nerve palsy	22.45	10.78	7	96953	80	79647348
Sleep disorder	22.27	10.78	44	96916	85633	79561795
Intracranial haematoma	22.22	10.78	14	96946	926	79646502
Right ventricular failure	22.21	10.78	71	96889	23426	79624002
Vision blurred	22.21	10.78	61	96899	105837	79541591
Aneurysm ruptured	22.03	10.78	14	96946	940	79646488
Bursitis	22.03	10.78	8	96952	35836	79611592
Hypernatraemia	22.00	10.78	52	96908	14399	79633029
Basal cell carcinoma	21.88	10.78	9	96951	37366	79610062
Pancreatic haemorrhage	21.49	10.78	7	96953	93	79647335
Renal artery thrombosis	21.48	10.78	11	96949	488	79646940
Dry eye	21.45	10.78	9	96951	36922	79610506
Osteonecrosis of jaw	21.41	10.78	13	96947	43213	79604215
Hypoaesthesia	21.39	10.78	129	96831	179223	79468205
Venoocclusive disease	21.23	10.78	27	96933	4546	79642882
Joint range of motion decreased	21.19	10.78	7	96953	33275	79614153
Hypoaldosteronism	21.06	10.78	10	96950	376	79647052
Kounis syndrome	21.02	10.78	26	96934	4256	79643172
Cerebral venous thrombosis	20.91	10.78	21	96939	2732	79644696
Cytokine release syndrome	20.87	10.78	93	96867	35905	79611523
Medical device site haemorrhage	20.71	10.78	8	96952	179	79647249
Intentional product misuse	20.58	10.78	54	96906	95111	79552317
Contusion	20.49	10.78	102	96858	148674	79498754
Hepatic cytolysis	20.39	10.78	76	96884	27075	79620353
Dehydration	20.39	10.78	198	96762	247989	79399439
Immune effector cell-associated neurotoxicity syndrome	20.30	10.78	30	96930	5818	79641610
Protein S decreased	20.30	10.78	7	96953	112	79647316
Blood uric acid increased	20.26	10.78	48	96912	13312	79634116
Intrapericardial thrombosis	20.24	10.78	6	96954	57	79647371
Circulatory collapse	20.12	10.78	95	96865	37573	79609855
Renal vein thrombosis	20.09	10.78	11	96949	560	79646868
Fibrin D dimer increased	20.05	10.78	37	96923	8617	79638811
Delayed graft function	20.03	10.78	23	96937	3484	79643944
Contraindicated product administered	20.02	10.78	111	96849	157427	79490001
Paratonia	19.98	10.78	5	96955	23	79647405
Live birth	19.92	10.78	59	96901	18685	79628743
Peritoneal haematoma	19.78	10.78	8	96952	203	79647225
Hyperphosphataemia	19.72	10.78	31	96929	6345	79641083
Osteoporosis	19.70	10.78	22	96938	54090	79593338
Transcription medication error	19.63	10.78	10	96950	439	79646989
Pulmonary fibrosis	19.53	10.78	15	96945	44097	79603331
Protein urine present	19.49	10.78	40	96920	10072	79637356
Foot deformity	19.44	10.78	3	96957	24071	79623357
Abnormal behaviour	19.41	10.78	10	96950	36411	79611017
Petechiae	19.31	10.78	62	96898	20503	79626925
Treatment noncompliance	19.31	10.78	21	96939	52247	79595181
Post procedural haematoma	19.24	10.78	19	96941	2423	79645005
Accidental exposure to product	19.23	10.78	7	96953	31315	79616113
Joint stiffness	19.23	10.78	13	96947	40817	79606611
Blood aldosterone decreased	19.20	10.78	4	96956	6	79647422
Tendonitis	19.18	10.78	3	96957	23827	79623601
Retinal pigment epitheliopathy	19.11	10.78	10	96950	464	79646964
Peliosis hepatis	19.04	10.78	7	96953	136	79647292
Sedation	19.00	10.78	21	96939	51874	79595554
Cerebral amyloid angiopathy	18.96	10.78	9	96951	338	79647090
Portal vein thrombosis	18.96	10.78	29	96931	5798	79641630
Cough	18.85	10.78	323	96637	366466	79280962
Aneurysm recanalisation	18.82	10.78	4	96956	7	79647421
Cerebral artery occlusion	18.63	10.78	16	96944	1706	79645722
Acute right ventricular failure	18.63	10.78	9	96951	352	79647076
Acne	18.62	10.78	5	96955	27185	79620243
Musculoskeletal pain	18.58	10.78	63	96897	102291	79545137
Coronary artery aneurysm	18.54	10.78	7	96953	147	79647281
Pelvic haematoma	18.41	10.78	12	96948	842	79646586
Mouth ulceration	18.39	10.78	12	96948	38382	79609046
Premature labour	18.35	10.78	35	96925	8355	79639073
Choroidal effusion	18.34	10.78	11	96949	666	79646762
Enterococcal infection	18.29	10.78	51	96909	15609	79631819
Malignant neoplasm progression	18.29	10.78	94	96866	135896	79511532
Peritonitis	18.24	10.78	75	96885	27961	79619467
Coagulation factor VIII level increased	18.21	10.78	5	96955	35	79647393
Irritability	18.20	10.78	14	96946	41130	79606298
Endocarditis	18.20	10.78	40	96920	10557	79636871
Toxic skin eruption	18.10	10.78	64	96896	22229	79625199
Catheter site haematoma	17.97	10.78	9	96951	381	79647047
Drug withdrawal syndrome	17.82	10.78	10	96950	34708	79612720
Necrotising oesophagitis	17.77	10.78	13	96947	1100	79646328
Pseudohypoaldosteronism	17.74	10.78	5	96955	39	79647389
International normalised ratio increased	17.70	10.78	169	96791	84552	79562876
Poor quality product administered	17.68	10.78	22	96938	3623	79643805
Foetal growth restriction	17.65	10.78	17	96943	2102	79645326
Gastric disorder	17.52	10.78	12	96948	37421	79610007
Vertigo	17.51	10.78	36	96924	69046	79578382
Frequent bowel movements	17.47	10.78	7	96953	29532	79617896
Coronary artery dissection	17.45	10.78	13	96947	1131	79646297
Dysstasia	17.38	10.78	6	96954	27740	79619688
Blood blister	17.38	10.78	20	96940	3037	79644391
Mean cell haemoglobin concentration	17.31	10.78	5	96955	43	79647385
Nightmare	17.25	10.78	5	96955	25856	79621572
Orthostatic hypotension	17.19	10.78	26	96934	56138	79591290
Burkholderia test positive	17.14	10.78	10	96950	575	79646853
Livedo reticularis	17.14	10.78	23	96937	4080	79643348
Anisochromia	17.14	10.78	3	96957	0	79647428
Tonsillar haemorrhage	17.12	10.78	8	96952	290	79647138
Ventricular asystole	17.12	10.78	8	96952	290	79647138
Ventricular arrhythmia	17.07	10.78	35	96925	8805	79638623
Drug therapy	16.88	10.78	13	96947	1188	79646240
White blood cell count decreased	16.85	10.78	147	96813	188141	79459287
Food interaction	16.78	10.78	15	96945	1687	79645741
Thrombectomy	16.77	10.78	8	96952	304	79647124
False negative investigation result	16.77	10.78	8	96952	304	79647124
Staphylococcus test positive	16.67	10.78	29	96931	6452	79640976
Skin ulcer	16.64	10.78	25	96935	54125	79593303
Peripheral artery aneurysm	16.64	10.78	9	96951	447	79646981
Analgesic therapy	16.59	10.78	12	96948	997	79646431
Threatened labour	16.55	10.78	10	96950	614	79646814
Haemodialysis complication	16.53	10.78	8	96952	314	79647114
Arterial rupture	16.46	10.78	11	96949	805	79646623
Sciatica	16.44	10.78	10	96950	33212	79614216
Vaginal haemorrhage	16.33	10.78	61	96899	21756	79625672
Pneumothorax	16.29	10.78	73	96887	28250	79619178
Stillbirth	16.26	10.78	22	96938	3933	79643495
Antithrombin III deficiency	16.25	10.78	6	96954	118	79647310
Urea renal clearance decreased	16.24	10.78	4	96956	17	79647411
Thrombin time abnormal	16.24	10.78	4	96956	17	79647411
Phaeochromocytoma crisis	16.18	10.78	8	96952	329	79647099
Serratia sepsis	16.18	10.78	7	96953	211	79647217
Intracranial pressure increased	16.13	10.78	33	96927	8289	79639139
Pseudomonas infection	16.11	10.78	59	96901	20844	79626584
Cardiovascular insufficiency	16.10	10.78	19	96941	2962	79644466
Hip arthroplasty	16.03	10.78	12	96948	35744	79611684
Leg amputation	16.01	10.78	21	96939	3645	79643783
Atrial rupture	15.89	10.78	5	96955	59	79647369
Nausea	15.88	10.78	978	95982	956218	78691210
Cerebrovascular disorder	15.83	10.78	21	96939	3684	79643744
Blister	15.83	10.78	83	96877	119393	79528035
Haemorrhage subcutaneous	15.74	10.78	24	96936	4785	79642643
Stress cardiomyopathy	15.73	10.78	39	96921	11127	79636301
Alveolitis necrotising	15.71	10.78	4	96956	20	79647408
Neuropathy peripheral	15.63	10.78	104	96856	141201	79506227
Haematemesis	15.60	10.78	113	96847	52151	79595277
Bronchopulmonary aspergillosis	15.59	10.78	61	96899	22233	79625195
Urethral fistula	15.55	10.78	4	96956	21	79647407
Subclavian vein thrombosis	15.55	10.78	17	96943	2440	79644988
Gestational hypertension	15.51	10.78	15	96945	1864	79645564
Delusion	15.49	10.78	3	96957	20420	79627008
Pneumonia escherichia	15.48	10.78	11	96949	889	79646539
Obesity	15.48	10.78	12	96948	35113	79612315
Hallucination	15.41	10.78	53	96907	85692	79561736
Splenic haemorrhage	15.41	10.78	10	96950	696	79646732
Sleep apnoea syndrome	15.40	10.78	13	96947	36465	79610963
Hypertriglyceridaemia	15.39	10.78	42	96918	12698	79634730
Acute pulmonary oedema	15.32	10.78	45	96915	14185	79633243
Renal artery stenosis	15.29	10.78	20	96940	3462	79643966
Mouth haemorrhage	15.29	10.78	38	96922	10861	79636567
Nervousness	15.26	10.78	11	96949	33404	79614024
Insurance issue	15.20	10.78	26	96934	5707	79641721
Colitis ulcerative	15.15	10.78	12	96948	34730	79612698
Pelvic venous thrombosis	15.14	10.78	16	96944	2209	79645219
Palpitations	15.12	10.78	91	96869	126519	79520909
Tremor	15.12	10.78	133	96827	169950	79477478
Agitation	15.12	10.78	66	96894	99649	79547779
Hand amputation	15.07	10.78	3	96957	3	79647425
Arterial injury	15.03	10.78	10	96950	726	79646702
Incision site haematoma	14.99	10.78	6	96954	148	79647280
Haemarthrosis	14.94	10.78	26	96934	5786	79641642
Anaphylactoid reaction	14.92	10.78	25	96935	5397	79642031
Ruptured cerebral aneurysm	14.87	10.78	9	96951	554	79646874
Impaired work ability	14.70	10.78	3	96957	19678	79627750
Human herpesvirus 6 infection reactivation	14.70	10.78	9	96951	566	79646862
Mediastinal haemorrhage	14.68	10.78	5	96955	77	79647351
Heart rate irregular	14.61	10.78	11	96949	32668	79614760
Blood thrombin increased	14.60	10.78	3	96957	4	79647424
Dystonia	14.53	10.78	4	96956	21395	79626033
Influenza like illness	14.52	10.78	42	96918	71665	79575763
Complications of transplanted kidney	14.48	10.78	27	96933	6339	79641089
Capillary fragility test	14.45	10.78	4	96956	29	79647399
Paranoia	14.44	10.78	3	96957	19429	79627999
Klebsiella infection	14.41	10.78	47	96913	15673	79631755
Left ventricular dysfunction	14.38	10.78	54	96906	19307	79628121
Hypertensive nephropathy	14.31	10.78	11	96949	1003	79646425
Tooth disorder	14.28	10.78	7	96953	26226	79621202
Embolism arterial	14.22	10.78	13	96947	1505	79645923
Dyspnoea exertional	14.22	10.78	56	96904	87017	79560411
Alanine aminotransferase decreased	14.22	10.78	13	96947	1506	79645922
Sleep disorder therapy	14.21	10.78	11	96949	1013	79646415
HELLP syndrome	14.21	10.78	10	96950	796	79646632
Microstomia	14.20	10.78	3	96957	5	79647423
Bacteraemia	14.18	10.78	78	96882	32746	79614682
Platelet dysfunction	14.14	10.78	8	96952	434	79646994
Speech disorder	14.11	10.78	28	96932	54417	79593011
Drug-device interaction	14.11	10.78	5	96955	87	79647341
Thrombophlebitis migrans	14.06	10.78	8	96952	439	79646989
Premature baby	14.01	10.78	20	96940	3760	79643668
Inferior vena caval occlusion	14.00	10.78	4	96956	33	79647395
Nasal congestion	13.98	10.78	47	96913	76505	79570923
Graft haemorrhage	13.96	10.78	5	96955	90	79647338
Haemoglobin increased	13.93	10.78	26	96934	6106	79641322
Cholestatic liver injury	13.89	10.78	23	96937	4918	79642510
Overdose	13.87	10.78	150	96810	184056	79463372
Cerebellar embolism	13.85	10.78	3	96957	6	79647422
Migraine	13.83	10.78	57	96903	87436	79559992
Renal impairment	13.80	10.78	269	96691	157514	79489914
Movement disorder	13.78	10.78	8	96952	27251	79620177
Femur fracture	13.76	10.78	16	96944	38636	79608792
Carotid intima-media thickness increased	13.66	10.78	5	96955	96	79647332
Breast haematoma	13.65	10.78	6	96954	188	79647240
Blood pressure increased	13.65	10.78	178	96782	211182	79436246
Incision site haemorrhage	13.64	10.78	11	96949	1075	79646353
Lumbar puncture	13.59	10.78	6	96954	190	79647238
Myiasis	13.59	10.78	4	96956	37	79647391
Extraocular muscle disorder	13.58	10.78	7	96953	315	79647113
Haemorrhagic cholecystitis	13.56	10.78	5	96955	98	79647330
Paradoxical embolism	13.50	10.78	4	96956	38	79647390
Pyrexia	13.46	10.78	978	95982	677731	78969697
Transmission of an infectious agent via product	13.45	10.78	6	96954	195	79647233
Oropharyngeal pain	13.38	10.78	78	96882	109275	79538153
Aspartate aminotransferase decreased	13.37	10.78	11	96949	1106	79646322
Fear	13.35	10.78	5	96955	21981	79625447
Pulmonary oedema	13.32	10.78	165	96795	88089	79559339
Factor VIII inhibition	13.26	10.78	7	96953	331	79647097
Vascular access site haematoma	13.25	10.78	3	96957	8	79647420
Platelet aggregation abnormal	13.22	10.78	4	96956	41	79647387
Medical device site haematoma	13.22	10.78	4	96956	41	79647387
Necrosis	13.21	10.78	33	96927	9460	79637968
Device related infection	13.19	10.78	79	96881	34215	79613213
Sinus arrest	13.18	10.78	19	96941	3603	79643825
Basal ganglia haemorrhage	13.16	10.78	13	96947	1658	79645770
Breast cancer	13.12	10.78	13	96947	33768	79613660
Toothache	13.07	10.78	4	96956	19966	79627462
Somnolence	13.07	10.78	208	96752	238773	79408655
Hyperlactacidaemia	13.06	10.78	24	96936	5571	79641857
Opportunistic infection	13.04	10.78	17	96943	2933	79644495
Leukocyturia	13.04	10.78	14	96946	1969	79645459
Aspartate aminotransferase increased	13.03	10.78	239	96721	138402	79509026
Primary adrenal insufficiency	13.01	10.78	6	96954	211	79647217
Protein S increased	12.99	10.78	3	96957	9	79647419
Coronary vascular graft occlusion	12.99	10.78	3	96957	9	79647419
Eosinophil cationic protein increased	12.97	10.78	4	96956	44	79647384
Hepatic function abnormal	12.96	10.78	141	96819	72966	79574462
Brain stem infarction	12.93	10.78	14	96946	1987	79645441
Body temperature decreased	12.92	10.78	12	96948	32133	79615295
Carotid artery dissection	12.90	10.78	7	96953	350	79647078
Hyponatraemia	12.89	10.78	295	96665	177553	79469875
Multiple sclerosis relapse	12.88	10.78	23	96937	46510	79600918
Lipoedema	12.88	10.78	6	96954	216	79647212
Venous thrombosis limb	12.87	10.78	21	96939	4436	79642992
Haemobilia	12.82	10.78	8	96952	520	79646908
Product contamination microbial	12.78	10.78	10	96950	936	79646492
Thoracic haemorrhage	12.78	10.78	6	96954	220	79647208
Emotional distress	12.73	10.78	18	96942	39951	79607477
Prostate cancer	12.70	10.78	13	96947	33255	79614173
Extravasation	12.68	10.78	19	96941	3731	79643697
Bladder cancer	12.62	10.78	4	96956	19522	79627906
Underdose	12.60	10.78	13	96947	33138	79614290
Myocardial haemorrhage	12.58	10.78	4	96956	49	79647379
Pre-eclampsia	12.58	10.78	27	96933	7014	79640414
Epidermolysis	12.57	10.78	10	96950	958	79646470
Injection site bruising	12.53	10.78	19	96941	40983	79606445
Thrombotic stroke	12.51	10.78	9	96951	742	79646686
Bradycardia	12.50	10.78	233	96727	135324	79512104
Penile necrosis	12.50	10.78	4	96956	50	79647378
Blood pressure diastolic decreased	12.48	10.78	11	96949	30205	79617223
Vascular parkinsonism	12.47	10.78	5	96955	124	79647304
Lip swelling	12.46	10.78	19	96941	40892	79606536
Muscular weakness	12.46	10.78	130	96830	160599	79486829
Diabetes mellitus inadequate control	12.44	10.78	7	96953	24257	79623171
Febrile neutropenia	12.34	10.78	368	96592	230631	79416797
Rheumatoid nodule	12.34	10.78	3	96957	17435	79629993
Kidney rupture	12.32	10.78	6	96954	239	79647189
Systemic candida	12.31	10.78	26	96934	6680	79640748
Superior vena cava syndrome	12.30	10.78	11	96949	1238	79646190
Spinal cord haemorrhage	12.21	10.78	8	96952	566	79646862
Bone disorder	12.20	10.78	4	96956	19109	79628319
Full blood count abnormal	12.13	10.78	19	96941	40455	79606973
Myocardial rupture	12.09	10.78	6	96954	249	79647179
Anger	12.05	10.78	3	96957	17159	79630269
Injection site plaque	12.04	10.78	5	96955	136	79647292
Thrombolysis	11.98	10.78	6	96954	254	79647174
Ergot poisoning	11.97	10.78	5	96955	138	79647290
Manufacturing materials issue	11.95	10.78	3	96957	14	79647414
Urticaria	11.95	10.78	156	96804	185045	79462383
Myelomalacia	11.84	10.78	5	96955	142	79647286
Spontaneous haemorrhage	11.83	10.78	9	96951	808	79646620
Postpartum haemorrhage	11.81	10.78	12	96948	1583	79645845
Rhinocerebral mucormycosis	11.79	10.78	10	96950	1048	79646380
Ureteric haemorrhage	11.78	10.78	3	96957	15	79647413
Septic rash	11.78	10.78	3	96957	15	79647413
Platelet aggregation test	11.78	10.78	4	96956	61	79647367
Aphthous ulcer	11.77	10.78	3	96957	16886	79630542
Iron deficiency	11.77	10.78	34	96926	10620	79636808
Hypoxic-ischaemic encephalopathy	11.75	10.78	28	96932	7792	79639636
Exostosis	11.73	10.78	3	96957	16855	79630573
Paralysis	11.72	10.78	39	96921	13138	79634290
Depressed mood	11.67	10.78	26	96934	48454	79598974
Nonreassuring foetal heart rate pattern	11.62	10.78	3	96957	16	79647412
Coronary artery occlusion	11.61	10.78	43	96917	15272	79632156
Kidney transplant rejection	11.61	10.78	33	96927	10213	79637215
Central venous catheterisation	11.60	10.78	17	96943	3272	79644156
Injection site mass	11.59	10.78	5	96955	20179	79627249
Abortion early	11.47	10.78	3	96957	17	79647411
Lower limb fracture	11.47	10.78	7	96953	23208	79624220
White blood cell count increased	11.46	10.78	140	96820	74493	79572935
Electrocardiogram T wave alternans	11.43	10.78	4	96956	67	79647361
Device loosening	11.39	10.78	7	96953	443	79646985
Cerebral artery thrombosis	11.37	10.78	10	96950	1101	79646327
Device occlusion	11.35	10.78	36	96924	11830	79635598
Basophil count decreased	11.34	10.78	6	96954	285	79647143
Tricuspid valve stenosis	11.33	10.78	3	96957	18	79647410
Nutritional condition abnormal	11.32	10.78	10	96950	1107	79646321
Respiratory tract oedema	11.29	10.78	9	96951	865	79646563
Tracheal haemorrhage	11.18	10.78	8	96952	654	79646774
Lower gastrointestinal haemorrhage	11.18	10.78	44	96916	16081	79631347
Reperfusion arrhythmia	11.17	10.78	6	96954	294	79647134
Coronary artery reocclusion	11.17	10.78	5	96955	164	79647264
Haematidrosis	11.16	10.78	4	96956	72	79647356
Catheter site thrombosis	11.15	10.78	6	96954	295	79647133
Flatulence	11.05	10.78	22	96938	42702	79604726
Pituitary haemorrhage	10.96	10.78	6	96954	305	79647123
Embolism venous	10.94	10.78	19	96941	4220	79643208
Limbal swelling	10.93	10.78	3	96957	21	79647407
Organic brain syndrome	10.92	10.78	7	96953	477	79646951
Infusion site extravasation	10.91	10.78	32	96928	10076	79637352
Hypoalbuminaemia	10.86	10.78	53	96907	21244	79626184
Subdural haemorrhage	10.84	10.78	23	96937	5925	79641503
Recurrence of neuromuscular blockade	10.82	10.78	6	96954	313	79647115
Out of specification test results	10.81	10.78	5	96955	177	79647251

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	B01AB01	BLOOD AND BLOOD FORMING ORGANS ANTITHROMBOTIC AGENTS ANTITHROMBOTIC AGENTS Heparin group
ATC	B01AB51	BLOOD AND BLOOD FORMING ORGANS ANTITHROMBOTIC AGENTS ANTITHROMBOTIC AGENTS Heparin group
ATC	C05BA03	CARDIOVASCULAR SYSTEM VASOPROTECTIVES ANTIVARICOSE THERAPY Heparins or heparinoids for topical use
ATC	C05BA53	CARDIOVASCULAR SYSTEM VASOPROTECTIVES ANTIVARICOSE THERAPY Heparins or heparinoids for topical use
ATC	S01XA14	SENSORY ORGANS OPHTHALMOLOGICALS OTHER OPHTHALMOLOGICALS Other ophthalmologicals
FDA CS	M0010187	Heparin
FDA EPC	N0000175474	Unfractionated Heparin
MeSH PA	D000925	Anticoagulants
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D005343	Fibrinolytic Agents
MeSH PA	D006401	Hematologic Agents
FDA EPC	N0000175980	Anti-coagulant
CHEBI has role	CHEBI:50249	anticoagulants

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Disseminated intravascular coagulation	indication	67406007	DOID:11247
Deep venous thrombosis	indication	128053003
Pulmonary thromboembolism	indication	233935004
Peripheral arterial embolism	indication	286959000
Non-Q wave myocardial infarction	indication	314207007
Prevention of deep vein thrombosis	indication	439993001
Deep Vein Thrombosis with Pulmonary Embolism	indication
Prevention of Recurrent Venous Thrombosis Associated with Malignancy	indication
Pulmonary Thromboembolism Prevention	indication
Peripheral Arterial Thromboembolism Prevention	indication
Maintain Patency of Indwelling Vascular Catheter	indication
Prevention of Ischemic Complications of Non-Q Wave MI	indication
Prevention of Cardiac Ischemia in Unstable Angina	indication
Myocardial infarction	off-label use	22298006	DOID:5844
Coronavirus infection	off-label use	186747009
Acute coronary syndrome	off-label use	394659003
Percutaneous coronary intervention	off-label use	415070008
Intracranial hemorrhage	contraindication	1386000
Diabetic retinopathy	contraindication	4855003	DOID:8947
Hypertensive retinopathy	contraindication	6962006	DOID:11561
Retinal disorder	contraindication	29555009	DOID:5679
Antithrombin III deficiency	contraindication	36351005	DOID:3755
Gastrointestinal ulcer	contraindication	40845000
Threatened abortion	contraindication	54048003	DOID:9667
Acute nephropathy	contraindication	58574008
Hepatic failure	contraindication	59927004
Ulcerative colitis	contraindication	64766004	DOID:8577
Blood coagulation disorder	contraindication	64779008	DOID:1247
Osteoporosis	contraindication	64859006	DOID:11476
Operation on brain	contraindication	70586009
Heparin-induced thrombocytopenia	contraindication	73397007
Gastrointestinal hemorrhage	contraindication	74474003
Ulceration of intestine	contraindication	85942002
Acute gastric ulcer with hemorrhage	contraindication	89748001
Hemophilia	contraindication	90935002
Disorder of biliary tract	contraindication	105997008	DOID:9741
Procedure on central nervous system	contraindication	118679007
Bleeding	contraindication	131148009
Disease of blood AND/OR blood-forming organ	contraindication	191124002	DOID:74
Hemorrhagic cerebral infarction	contraindication	230706003
Local anesthetic intrathecal block	contraindication	231249005
Infective endocarditis	contraindication	233850007
Procedure on spine	contraindication	238181003
Qualitative platelet disorder	contraindication	267532001
Diverticulitis of gastrointestinal tract	contraindication	271366000
Cerebral hemorrhage	contraindication	274100004
Lumbar puncture	contraindication	277762005
Bacterial endocarditis	contraindication	301183007
Thrombocytopenic disorder	contraindication	302215000	DOID:1588
Dissection of aorta	contraindication	308546005
Arteriosclerosis obliterans	contraindication	361133006	DOID:5160
Surgical procedure on eye proper	contraindication	373353005
Hypertensive urgency	contraindication	443482000
Placement of Epidural Catheter	contraindication
Thrombosis in Heparin Induced Thrombocytopenia	contraindication
Platelet Aggregation Inhibition	contraindication
Spinal Epidural Hematoma	contraindication
Significant Bleeding	contraindication
Indwelling Vascular Catheter	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Antithrombin-III	Secreted	P01008	ANT3_HUMAN	ACTIVATOR	Kd	7.85		IUPHAR	CHEMBL
Spike glycoprotein	Glycoprotein		SPIKE_SARS2		Kd	10.14		IUPHAR
Spike glycoprotein, S glycoprotein	Unclassified		SPIKE_SARS		Kd	6.30		IUPHAR

External reference:

ID	Source
D02112	KEGG_DRUG
4017546	VANDF
4017547	VANDF
4017549	VANDF
4018538	VANDF
C0019134	UMLSCUI
CHEBI:28304	CHEBI
CHEMBL1909300	ChEMBL_ID
CHEMBL4650299	ChEMBL_ID
CHEMBL1201657	ChEMBL_ID
D006493	MESH_DESCRIPTOR_UI
DB01109	DRUGBANK_ID
4214	IUPHAR_LIGAND_ID
T2410KM04A	UNII
20044	RXNORM
32703	MMSL
3649	MMSL
4821	MMSL
d00252	MMSL
002079	NDDF
002081	NDDF
015153	NDDF
29725000	SNOMEDCT_US
372877000	SNOMEDCT_US
412201008	SNOMEDCT_US
412401006	SNOMEDCT_US
50045009	SNOMEDCT_US
784398008	SNOMEDCT_US
84812008	SNOMEDCT_US
M7J	PDB_CHEM_ID
CHEMBL1201513	ChEMBL_ID
392	INN_ID
37270-89-6	SECONDARY_CAS_RN
92044406	PUBCHEM_CID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0043	INJECTION	1000 [USPU]	INTRAVENOUS	NDA	26 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0058	INJECTION	1000 [USPU]	INTRAVENOUS	NDA	26 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0059	INJECTION	5000 [USPU]	INTRAVENOUS	NDA	26 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0062	INJECTION	10000 [USPU]	INTRAVENOUS	NDA	26 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0137	INJECTION	1000 [USPU]	INTRAVENOUS	NDA	26 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0264-5705	INJECTION	5000 [USPU]	INTRAVENOUS	ANDA	20 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0264-5705	INJECTION	5000 [USPU]	INTRAVENOUS	ANDA	20 sections
Heparin Sodium in Dextrose	HUMAN PRESCRIPTION DRUG LABEL	2	0264-9567	INJECTION	4000 [USPU]	INTRAVENOUS	NDA	19 sections
Heparin Sodium in Dextrose	HUMAN PRESCRIPTION DRUG LABEL	2	0264-9567	INJECTION	4000 [USPU]	INTRAVENOUS	NDA	19 sections
Heparin Sodium in Dextrose	HUMAN PRESCRIPTION DRUG LABEL	2	0264-9577	INJECTION	5000 [USPU]	INTRAVENOUS	NDA	19 sections
Heparin Sodium in Dextrose	HUMAN PRESCRIPTION DRUG LABEL	2	0264-9577	INJECTION	5000 [USPU]	INTRAVENOUS	NDA	19 sections
Heparin Sodium in Dextrose	HUMAN PRESCRIPTION DRUG LABEL	2	0264-9587	INJECTION	10000 [USPU]	INTRAVENOUS	NDA	19 sections
Heparin Sodium in Dextrose	HUMAN PRESCRIPTION DRUG LABEL	2	0264-9587	INJECTION	10000 [USPU]	INTRAVENOUS	NDA	19 sections
Heparin Sodium in Sodium Chloride	HUMAN PRESCRIPTION DRUG LABEL	1	0264-9872	INJECTION	200 [USPU]	INTRAVENOUS	NDA	23 sections
HEPARIN SODIUM IN SODIUM CHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0338-0424	INJECTION, SOLUTION	200 [USPU]	INTRAVENOUS	NDA	26 sections
HEPARIN SODIUM IN SODIUM CHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0338-0424	INJECTION, SOLUTION	200 [USPU]	INTRAVENOUS	NDA	26 sections
HEPARIN SODIUM IN SODIUM CHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0338-0424	INJECTION, SOLUTION	200 [USPU]	INTRAVENOUS	NDA	26 sections
HEPARIN SODIUM IN SODIUM CHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0338-0428	INJECTION, SOLUTION	200 [USPU]	INTRAVENOUS	NDA	26 sections
HEPARIN SODIUM IN SODIUM CHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0338-0428	INJECTION, SOLUTION	200 [USPU]	INTRAVENOUS	NDA	26 sections
HEPARIN SODIUM IN SODIUM CHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0338-0428	INJECTION, SOLUTION	200 [USPU]	INTRAVENOUS	NDA	26 sections
HEPARIN SODIUM IN SODIUM CHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0338-0431	INJECTION, SOLUTION	200 [USPU]	INTRAVENOUS	NDA	26 sections
HEPARIN SODIUM IN SODIUM CHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0338-0431	INJECTION, SOLUTION	200 [USPU]	INTRAVENOUS	NDA	26 sections
HEPARIN SODIUM IN SODIUM CHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0338-0431	INJECTION, SOLUTION	200 [USPU]	INTRAVENOUS	NDA	26 sections
HEPARIN SODIUM IN SODIUM CHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0338-0433	INJECTION, SOLUTION	200 [USPU]	INTRAVENOUS	NDA	26 sections
HEPARIN SODIUM IN SODIUM CHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0338-0433	INJECTION, SOLUTION	200 [USPU]	INTRAVENOUS	NDA	26 sections
HEPARIN SODIUM IN SODIUM CHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0338-0433	INJECTION, SOLUTION	200 [USPU]	INTRAVENOUS	NDA	26 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9872	INJECTION, SOLUTION	5000 [USPU]	INTRAVENOUS	ANDA	14 sections
Heparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9872	INJECTION, SOLUTION	5000 [USPU]	INTRAVENOUS	ANDA	14 sections
HEPARIN SODIUM	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9873	INJECTION	10000 [USPU]	INTRAVENOUS	ANDA	14 sections
HEPARIN SODIUM	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9873	INJECTION	10000 [USPU]	INTRAVENOUS	ANDA	14 sections