halothane 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
halogenated compounds used as general inhalation anaesthetics 1356 151-67-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • halothane
  • anestan
  • fluothane
  • ftorotan
  • narcotan
  • narcotane
  • rhodialothan
A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)
  • Molecular weight: 197.38
  • Formula: C2HBrClF3
  • CLOGP: 2.46
  • LIPINSKI: 0
  • HAC: 0
  • HDO: 0
  • TPSA:
  • ALOGS: -1.71
  • ROTB: 1

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
March 12, 1958 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N01AB01 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, GENERAL
Halogenated hydrocarbons
MeSH PA D000777 Anesthetics
MeSH PA D018685 Anesthetics, Inhalation
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
CHEBI has role CHEBI:38870 inhalation anesthetics

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
General anesthesia indication 50697003
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Benign intracranial hypertension contraindication 68267002 DOID:11459
Disease of liver contraindication 235856003 DOID:409
Malignant hyperthermia contraindication 405501007




🐶 Veterinary Drug Use

SpeciesUseRelation
Multiple Species Induction and maintenance of anesthesia Indication

🐶 Veterinary products

ProductApplicantIngredients
Fluothane, Halothane, USP Zoetis Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Potassium channel subfamily K member 2 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 3 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 9 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 10 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 18 Ion channel OPENER CHEMBL CHEMBL
Glycine receptor (alpha-1/beta) Ion channel POSITIVE MODULATOR CHEMBL CHEMBL
GABA-A receptor; anion channel Ion channel POSITIVE ALLOSTERIC MODULATOR CHEMBL CHEMBL

External reference:

IDSource
4018499 VUID
N0000146821 NUI
D00542 KEGG_DRUG
4018499 VANDF
C0018549 UMLSCUI
CHEBI:5615 CHEBI
CHEMBL931 ChEMBL_ID
DB01159 DRUGBANK_ID
D006221 MESH_DESCRIPTOR_UI
3562 PUBCHEM_CID
697 INN_ID
2401 IUPHAR_LIGAND_ID
UQT9G45D1P UNII
1302180 RXNORM
4820 MMSL
55 MMSL
601 MMSL
d00251 MMSL
001394 NDDF
387351001 SNOMEDCT_US
63682003 SNOMEDCT_US

Pharmaceutical products:

None