haloperidol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antipsychotics, haloperidol derivatives 1353 52-86-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • haloperidol
  • aloperidin
  • haloperin
  • sigaperidol
  • haloperidol lactate
A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
  • Molecular weight: 375.87
  • Formula: C21H23ClFNO2
  • CLOGP: 3.85
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 40.54
  • ALOGS: -4.93
  • ROTB: 6
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
8 mg O
8 mg P
3.30 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.04 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.57 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 60 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 17 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 7.80 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.08 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 35 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
April 12, 1967 FDA ORTHO MCNEIL

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuroleptic malignant syndrome 1642.36 14.77 513 40811 11543 63436155
Extrapyramidal disorder 1399.16 14.77 465 40859 12819 63434879
Intentional self-injury 853.59 14.77 389 40935 25298 63422400
Drug interaction 483.01 14.77 666 40658 228465 63219233
Akathisia 477.83 14.77 191 41133 8955 63438743
Catatonia 456.21 14.77 153 41171 4324 63443374
Dystonia 417.39 14.77 196 41128 13623 63434075
Sopor 383.47 14.77 216 41108 21948 63425750
Muscle rigidity 362.45 14.77 168 41156 11332 63436366
Agitation 332.28 14.77 290 41034 59467 63388231
Salivary hypersecretion 322.03 14.77 137 41187 7529 63440169
Hyperprolactinaemia 314.82 14.77 112 41212 3788 63443910
Psychotic disorder 303.40 14.77 196 41128 25516 63422182
Delusion 289.35 14.77 146 41178 11871 63435827
Hallucination, auditory 286.13 14.77 148 41176 12676 63435022
Intentional overdose 271.83 14.77 286 41038 73866 63373832
Delirium 262.43 14.77 236 41088 50305 63397393
Electrocardiogram QT prolonged 246.09 14.77 245 41079 59285 63388413
Parkinsonism 245.99 14.77 125 41199 10314 63437384
Aggression 238.26 14.77 163 41161 23335 63424363
Somnolence 238.02 14.77 421 40903 178264 63269434
Arthralgia 221.88 14.77 50 41274 569660 62878038
Suicide attempt 217.96 14.77 232 41092 60686 63387012
Pain 211.22 14.77 110 41214 740518 62707180
Sedation 206.94 14.77 184 41140 38625 63409073
Tardive dyskinesia 206.74 14.77 104 41220 8398 63439300
Psychomotor hyperactivity 203.78 14.77 111 41213 10552 63437146
Coma 200.60 14.77 228 41096 64136 63383562
Overdose 187.63 14.77 297 41027 114781 63332917
Fatigue 186.45 14.77 183 41141 887845 62559853
Schizophrenia 185.76 14.77 102 41222 9850 63437848
Hypothermia 176.30 14.77 110 41214 13471 63434227
Joint swelling 173.17 14.77 10 41314 327656 63120042
Torsade de pointes 162.95 14.77 104 41220 13247 63434451
Headache 152.73 14.77 114 41210 633127 62814571
Tremor 151.29 14.77 292 41032 131947 63315751
Restlessness 147.84 14.77 135 41189 29318 63418380
Abnormal behaviour 145.93 14.77 117 41207 21309 63426389
Weight increased 145.91 14.77 436 40888 260356 63187342
Alopecia 140.82 14.77 25 41299 337511 63110187
Rheumatoid arthritis 139.62 14.77 6 41318 253813 63193885
Arthropathy 138.30 14.77 3 41321 234789 63212909
Dyskinesia 138.29 14.77 135 41189 31867 63415831
Infusion related reaction 137.77 14.77 5 41319 245516 63202182
Abdominal discomfort 137.77 14.77 22 41302 320863 63126835
Blood creatine phosphokinase increased 136.44 14.77 131 41193 30299 63417399
Bradykinesia 133.62 14.77 66 41258 5122 63442576
Hallucination 132.87 14.77 171 41153 54646 63393052
Rash 132.57 14.77 103 41221 560768 62886930
Toxicity to various agents 130.44 14.77 405 40919 246845 63200853
Swelling 129.88 14.77 14 41310 275364 63172334
Depressed level of consciousness 129.56 14.77 180 41144 61898 63385800
Drug abuse 129.09 14.77 195 41129 72323 63375375
Dysarthria 124.12 14.77 146 41178 42565 63405133
Systemic lupus erythematosus 118.09 14.77 4 41320 208914 63238784
Confusional state 117.15 14.77 379 40945 236001 63211697
Sluggishness 115.18 14.77 60 41264 5209 63442489
Hypertonia 110.61 14.77 56 41268 4581 63443117
Mutism 109.91 14.77 41 41283 1589 63446109
Sinusitis 108.19 14.77 11 41313 226642 63221056
Tachycardia 108.09 14.77 238 41086 117918 63329780
Galactorrhoea 107.43 14.77 53 41271 4102 63443596
Suicidal ideation 104.26 14.77 163 41161 62258 63385440
Rhabdomyolysis 103.21 14.77 135 41189 43816 63403882
Treatment noncompliance 102.54 14.77 124 41200 37201 63410497
Cogwheel rigidity 102.37 14.77 41 41283 1929 63445769
Pruritus 102.19 14.77 54 41270 361399 63086299
Drug intolerance 101.63 14.77 37 41287 308624 63139074
Altered state of consciousness 100.80 14.77 102 41222 25128 63422570
Oculogyric crisis 100.59 14.77 39 41285 1682 63446016
Nasopharyngitis 99.35 14.77 22 41302 254235 63193463
Paranoia 97.53 14.77 72 41252 11607 63436091
Pain in extremity 97.48 14.77 47 41277 331439 63116259
Peripheral swelling 96.19 14.77 27 41297 265915 63181783
Bradyphrenia 89.23 14.77 56 41268 6924 63440774
Hyperthermia 89.21 14.77 62 41262 9094 63438604
Blood prolactin increased 88.54 14.77 44 41280 3459 63444239
Psychomotor retardation 87.27 14.77 45 41279 3825 63443873
Wound 86.11 14.77 5 41319 163258 63284440
Mental impairment 85.31 14.77 72 41252 14079 63433619
Contraindicated product administered 84.68 14.77 19 41305 217629 63230069
Encephalitis autoimmune 84.46 14.77 33 41291 1453 63446245
Pneumonia aspiration 84.07 14.77 108 41216 34432 63413266
Disorientation 83.19 14.77 115 41209 39337 63408361
Mania 83.07 14.77 67 41257 12300 63435398
Persecutory delusion 82.44 14.77 39 41285 2751 63444947
Embolism venous 80.86 14.77 40 41284 3114 63444584
Refusal of examination 80.53 14.77 20 41304 183 63447515
Torticollis 79.09 14.77 34 41290 1915 63445783
Drooling 78.74 14.77 42 41282 3826 63443872
Stupor 77.53 14.77 43 41281 4232 63443466
Discomfort 75.18 14.77 10 41314 167364 63280334
Cardiac arrest 74.19 14.77 177 41147 92368 63355330
Ileus paralytic 72.35 14.77 42 41282 4509 63443189
Negativism 70.60 14.77 21 41303 396 63447302
Hyponatraemia 70.05 14.77 195 41129 111705 63335993
Hypersensitivity 69.93 14.77 53 41271 292632 63155066
Drug level increased 69.85 14.77 80 41244 22656 63425042
Urinary retention 69.47 14.77 92 41232 30209 63417489
Lethargy 69.32 14.77 128 41196 55879 63391819
Toxic epidermal necrolysis 69.31 14.77 84 41240 25250 63422448
Psychotic symptom 69.22 14.77 29 41295 1532 63446166
Pleurothotonus 62.98 14.77 26 41298 1323 63446375
Serotonin syndrome 62.57 14.77 85 41239 28597 63419101
Hypernatraemia 61.50 14.77 46 41278 7563 63440135
Hypoxic-ischaemic encephalopathy 61.44 14.77 37 41287 4250 63443448
Pericarditis 61.19 14.77 7 41317 131572 63316126
Stereotypy 60.91 14.77 19 41305 423 63447275
Gestational diabetes 59.62 14.77 47 41277 8349 63439349
Intentional product misuse 59.42 14.77 126 41198 60791 63386907
Product dose omission issue 59.13 14.77 40 41284 234273 63213425
Leukopenia 57.85 14.77 144 41180 77146 63370552
Oromandibular dystonia 57.62 14.77 19 41305 508 63447190
Hyperreflexia 57.38 14.77 40 41284 5894 63441804
Arthritis 56.94 14.77 5 41319 115916 63331782
Dysphagia 56.05 14.77 155 41169 88430 63359268
Injection site pain 55.40 14.77 9 41315 129791 63317907
Behaviour disorder 54.81 14.77 31 41293 3168 63444530
Unresponsive to stimuli 54.63 14.77 87 41237 33729 63413969
Bradycardia 54.36 14.77 136 41188 73091 63374607
Granulocytopenia 54.30 14.77 38 41286 5634 63442064
Myocardial reperfusion injury 54.23 14.77 13 41311 101 63447597
Pulmonary embolism 53.15 14.77 182 41142 116502 63331196
Dyspnoea 53.07 14.77 236 41088 661077 62786621
Nausea 52.97 14.77 333 40991 854138 62593560
Diarrhoea 52.89 14.77 263 41061 715103 62732595
Accidental exposure to product by child 52.35 14.77 22 41302 1171 63446527
Cognitive disorder 51.63 14.77 113 41211 55702 63391996
Impaired healing 51.53 14.77 4 41320 102538 63345160
Mental disorder 50.85 14.77 73 41251 25846 63421852
Treatment failure 50.18 14.77 34 41290 199009 63248689
Miosis 49.73 14.77 40 41284 7313 63440385
Urticaria 49.45 14.77 23 41301 165779 63281919
Contusion 49.30 14.77 18 41306 150026 63297672
Eosinophil count decreased 48.04 14.77 25 41299 2165 63445533
Antipsychotic drug level increased 47.56 14.77 29 41295 3406 63444292
Disturbance in attention 46.90 14.77 87 41237 38102 63409596
Back pain 46.84 14.77 62 41262 264083 63183615
Therapeutic product effect decreased 46.08 14.77 35 41289 193152 63254546
Hyperammonaemic encephalopathy 45.56 14.77 25 41299 2409 63445289
Echolalia 45.18 14.77 13 41311 217 63447481
Inappropriate antidiuretic hormone secretion 45.14 14.77 53 41271 15409 63432289
Hallucination, visual 44.86 14.77 59 41265 19239 63428459
Mental status changes 44.66 14.77 87 41237 39512 63408186
Distractibility 44.53 14.77 15 41309 429 63447269
Apallic syndrome 44.50 14.77 17 41307 704 63446994
Abdominal pain upper 43.63 14.77 42 41282 206402 63241296
Respiratory failure 43.03 14.77 155 41169 101703 63345995
Leukocytosis 42.27 14.77 67 41257 25868 63421830
Fibromyalgia 40.80 14.77 3 41321 80417 63367281
Paraesthesia 40.66 14.77 26 41298 156940 63290758
Cough 40.40 14.77 81 41243 292662 63155036
Akinesia 40.23 14.77 20 41304 1573 63446125
White blood cell count increased 40.11 14.77 94 41230 48467 63399231
Psoriasis 39.50 14.77 5 41319 86952 63360746
Hallucinations, mixed 38.59 14.77 29 41295 4800 63442898
Hepatic enzyme increased 38.46 14.77 45 41279 202283 63245415
Neutropenia 38.20 14.77 219 41105 174786 63272912
Chest discomfort 38.19 14.77 12 41312 109957 63337741
Sexually inappropriate behaviour 38.12 14.77 10 41314 116 63447582
Osteoarthritis 37.70 14.77 8 41316 95335 63352363
Clonus 37.40 14.77 28 41296 4608 63443090
Waxy flexibility 36.93 14.77 10 41314 132 63447566
Schizoaffective disorder 36.77 14.77 25 41299 3537 63444161
Respiratory depression 36.73 14.77 45 41279 13670 63434028
Dizziness 36.50 14.77 150 41174 429775 63017923
Haemoglobin urine 36.39 14.77 10 41314 140 63447558
Musculoskeletal pain 35.97 14.77 8 41316 92269 63355429
Infection 35.54 14.77 59 41265 229114 63218584
Generalised tonic-clonic seizure 35.49 14.77 66 41258 28950 63418748
Somatic symptom disorder of pregnancy 34.99 14.77 9 41315 96 63447602
Injection site erythema 34.97 14.77 6 41318 83168 63364530
Folliculitis 34.62 14.77 3 41321 70314 63377384
Myocarditis 34.57 14.77 38 41286 10287 63437411
Herpes zoster 34.55 14.77 6 41318 82456 63365242
Stomatitis 34.55 14.77 24 41300 138701 63308997
Impulsive behaviour 34.52 14.77 18 41306 1565 63446133
Metabolic syndrome 34.47 14.77 18 41306 1570 63446128
Myalgia 34.36 14.77 27 41297 146502 63301196
Cannabinoid hyperemesis syndrome 34.10 14.77 8 41316 56 63447642
Speech disorder 33.94 14.77 79 41245 40550 63407148
Electroencephalogram abnormal 33.76 14.77 24 41300 3648 63444050
Illogical thinking 33.62 14.77 8 41316 60 63447638
Negative symptoms in schizophrenia 33.51 14.77 9 41315 115 63447583
Feeling guilty 33.34 14.77 13 41311 569 63447129
Social avoidant behaviour 33.32 14.77 22 41302 2966 63444732
Nephrogenic diabetes insipidus 33.32 14.77 15 41309 944 63446754
Tonic clonic movements 33.26 14.77 17 41307 1418 63446280
Asthma 33.21 14.77 21 41303 127540 63320158
Chest pain 33.11 14.77 56 41268 215903 63231795
Eosinophilic myocarditis 32.55 14.77 13 41311 607 63447091
Influenza 32.53 14.77 15 41309 108707 63338991
Sudden death 32.48 14.77 37 41287 10412 63437286
Dyspepsia 32.33 14.77 13 41311 102183 63345515
Vulvovaginal candidiasis 32.11 14.77 22 41302 3153 63444545
Polydipsia 32.09 14.77 23 41301 3541 63444157
Opisthotonus 31.70 14.77 11 41313 345 63447353
Nuchal rigidity 31.59 14.77 13 41311 656 63447042
Sinus bradycardia 31.54 14.77 43 41281 14508 63433190
Hypoaesthesia 31.41 14.77 38 41286 168355 63279343
Refusal of treatment by patient 31.15 14.77 27 41297 5470 63442228
Hypersexuality 31.11 14.77 12 41312 510 63447188
Seizure 30.93 14.77 169 41155 132465 63315233
Brain death 30.69 14.77 22 41302 3388 63444310
Amenorrhoea 30.64 14.77 35 41289 9879 63437819
Neutrophil count increased 30.17 14.77 45 41279 16482 63431216
Cardio-respiratory arrest 29.48 14.77 96 41228 59863 63387835
Irritability 29.11 14.77 64 41260 31630 63416068
COVID-19 28.92 14.77 19 41305 113084 63334614
Asthenia 28.83 14.77 140 41184 383464 63064234
Ill-defined disorder 28.24 14.77 9 41315 81746 63365952
Stress 27.89 14.77 5 41319 67162 63380536
Psychomotor skills impaired 27.78 14.77 18 41306 2350 63445348
Electrocardiogram PR prolongation 27.32 14.77 12 41312 712 63446986
Nasal congestion 27.03 14.77 5 41319 65655 63382043
Screaming 26.98 14.77 20 41304 3242 63444456
Bronchitis 26.87 14.77 25 41299 124910 63322788
Red blood cells urine 26.75 14.77 11 41313 554 63447144
Lower respiratory tract infection 26.70 14.77 28 41296 132279 63315419
Disorganised speech 26.49 14.77 14 41310 1251 63446447
Flushing 26.42 14.77 8 41316 75079 63372619
Dementia 25.86 14.77 45 41279 18749 63428949
Weight decreased 25.76 14.77 93 41231 276705 63170993
Grandiosity 25.67 14.77 9 41315 291 63447407
Thinking abnormal 25.45 14.77 33 41291 10610 63437088
Dermatitis exfoliative 25.40 14.77 24 41300 5435 63442263
False positive investigation result 25.22 14.77 11 41313 642 63447056
Flight of ideas 25.10 14.77 10 41314 464 63447234
Femoral neck fracture 24.52 14.77 29 41295 8494 63439204
Diabetic coma 24.23 14.77 11 41313 706 63446992
Parkinsonian gait 24.22 14.77 10 41314 509 63447189
Tongue biting 24.09 14.77 14 41310 1506 63446192
Dyspnoea exertional 23.96 14.77 5 41319 60297 63387401
Mydriasis 23.93 14.77 34 41290 11922 63435776
Duodenal stenosis 23.80 14.77 10 41314 532 63447166
Influenza like illness 23.72 14.77 7 41317 66817 63380881
Inflammation 23.62 14.77 12 41312 82261 63365437
Electroconvulsive therapy 23.59 14.77 6 41318 61 63447637
Blood phosphorus decreased 23.49 14.77 21 41303 4432 63443266
Agranulocytosis 23.36 14.77 51 41273 25083 63422615
Differential white blood cell count abnormal 23.26 14.77 11 41313 775 63446923
Reduced facial expression 23.20 14.77 15 41309 1951 63445747
Staring 23.18 14.77 14 41310 1616 63446082
Poisoning 23.17 14.77 36 41288 13664 63434034
Eosinophil count abnormal 23.01 14.77 10 41314 578 63447120
Blunted affect 22.93 14.77 8 41316 255 63447443
Autonomic nervous system imbalance 22.69 14.77 17 41307 2801 63444897
Muscle enzyme increased 22.56 14.77 7 41317 153 63447545
Electrolyte imbalance 22.50 14.77 44 41280 20032 63427666
Psychiatric decompensation 22.46 14.77 13 41311 1388 63446310
Communication disorder 22.20 14.77 16 41308 2484 63445214
Apathy 22.18 14.77 28 41296 8766 63438932
Eosinophilia 22.10 14.77 47 41277 22709 63424989
Acute psychosis 22.06 14.77 16 41308 2509 63445189
Product use issue 21.92 14.77 72 41252 220448 63227250
Myoclonus 21.84 14.77 38 41286 15830 63431868
Euphoric mood 21.82 14.77 21 41303 4866 63442832
Bone marrow eosinophilic leukocyte count increased 21.70 14.77 5 41319 32 63447666
Antipsychotic drug level below therapeutic 21.69 14.77 8 41316 300 63447398
Lactate pyruvate ratio increased 21.45 14.77 6 41318 90 63447608
Urinary incontinence 21.21 14.77 57 41267 31957 63415741
Mucosal dryness 20.87 14.77 16 41308 2728 63444970
Allergic hepatitis 20.84 14.77 5 41319 39 63447659
Self-medication 20.77 14.77 16 41308 2747 63444951
Delusion of reference 20.75 14.77 6 41318 102 63447596
Burning sensation 20.64 14.77 5 41319 54402 63393296
Exposure during pregnancy 20.46 14.77 172 41152 155375 63292323
Protrusion tongue 20.27 14.77 8 41316 362 63447336
Withdrawal syndrome 20.23 14.77 42 41282 19955 63427743
Dry skin 20.12 14.77 6 41318 56881 63390817
Hypokinesia 20.00 14.77 34 41290 13902 63433796
Rash pruritic 19.93 14.77 7 41317 59792 63387906
Ventricular fibrillation 19.81 14.77 31 41293 11836 63435862
Pulmonary vasculitis 19.75 14.77 6 41318 122 63447576
Hyperthermia malignant 19.68 14.77 10 41314 824 63446874
Psychotic behaviour 19.63 14.77 9 41315 591 63447107
Venous thrombosis limb 19.57 14.77 16 41308 2992 63444706
Wheezing 19.54 14.77 20 41304 95575 63352123
Diabetes mellitus 19.51 14.77 80 41244 55730 63391968
Night sweats 19.49 14.77 4 41320 48810 63398888
Lipids decreased 19.34 14.77 4 41320 14 63447684
Injection site reaction 19.25 14.77 7 41317 58517 63389181
Encephalopathy 19.13 14.77 62 41262 38558 63409140
Coma scale abnormal 19.07 14.77 20 41304 5133 63442565
Blood citric acid increased 18.98 14.77 5 41319 59 63447639
Mobility decreased 18.94 14.77 31 41293 121128 63326570
Brief psychotic disorder with marked stressors 18.90 14.77 5 41319 60 63447638
Intentional product use issue 18.83 14.77 34 41290 127858 63319840
Injection site swelling 18.79 14.77 4 41320 47568 63400130
Hepatitis acute 18.34 14.77 26 41298 9094 63438604
Epileptic encephalopathy 18.32 14.77 7 41317 290 63447408
Medication error 18.32 14.77 75 41249 52209 63395489
Haematochezia 18.31 14.77 6 41318 53538 63394160
Brain oedema 18.26 14.77 33 41291 14162 63433536
Carnitine deficiency 18.14 14.77 6 41318 162 63447536
Pressure of speech 18.00 14.77 9 41315 717 63446981
Neutrophilia 17.93 14.77 18 41306 4388 63443310
Cardiomyopathy alcoholic 17.88 14.77 4 41320 22 63447676
Muscle strength abnormal 17.88 14.77 5 41319 75 63447623
Aspiration 17.63 14.77 28 41296 10823 63436875
Labelled drug-food interaction medication error 17.60 14.77 6 41318 178 63447520
Poor personal hygiene 17.56 14.77 7 41317 325 63447373
Anticonvulsant drug level above therapeutic 17.47 14.77 8 41316 524 63447174
Blood pressure increased 17.46 14.77 51 41273 162011 63285687
Fall 17.43 14.77 355 40969 391979 63055719
Granulomatous liver disease 17.41 14.77 9 41315 769 63446929
Multiple sclerosis relapse 17.35 14.77 5 41319 48473 63399225
Illusion 17.34 14.77 10 41314 1060 63446638
Liver injury 17.12 14.77 9 41315 60511 63387187
Psychiatric symptom 17.10 14.77 19 41305 5204 63442494
Brain injury 17.09 14.77 22 41302 7021 63440677
Dry eye 17.00 14.77 3 41321 40758 63406940
Resting tremor 16.93 14.77 9 41315 814 63446884
Hypotension 16.86 14.77 260 41064 272344 63175354
Rhinorrhoea 16.78 14.77 11 41313 65566 63382132
Fluid retention 16.70 14.77 9 41315 59677 63388021
Ureteric obstruction 16.68 14.77 12 41312 1858 63445840
Blood glucose 16.47 14.77 4 41320 33 63447665
Somatic hallucination 16.47 14.77 3 41321 4 63447694
Foetal exposure during pregnancy 16.45 14.77 52 41272 31910 63415788
Retinitis pigmentosa 16.39 14.77 5 41319 103 63447595
Erythema 16.37 14.77 59 41265 175692 63272006
Diet refusal 16.30 14.77 8 41316 612 63447086
Cholestasis 16.18 14.77 49 41275 29385 63418313
Grimacing 15.60 14.77 7 41317 437 63447261
Gastrooesophageal reflux disease 15.39 14.77 24 41300 95615 63352083
Incorrect route of product administration 15.38 14.77 46 41278 27406 63420292
Electrocardiogram abnormal 15.35 14.77 24 41300 9155 63438543
Mental disorder due to a general medical condition 15.26 14.77 5 41319 131 63447567
Neurotoxicity 15.25 14.77 34 41290 16956 63430742
Intestinal dilatation 15.24 14.77 11 41313 1711 63445987
Multiple organ dysfunction syndrome 15.07 14.77 75 41249 56677 63391021
Hyperthyroidism 15.06 14.77 31 41293 14642 63433056
Tachyphrenia 15.04 14.77 10 41314 1364 63446334
Blood sodium decreased 14.90 14.77 42 41282 24210 63423488

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuroleptic malignant syndrome 1961.40 13.90 808 52466 17126 34886531
Extrapyramidal disorder 1782.91 13.90 688 52586 12192 34891465
Dystonia 729.98 13.90 348 52926 10497 34893160
Akathisia 625.58 13.90 286 52988 7823 34895834
Intentional self-injury 614.94 13.90 335 52939 13436 34890221
Muscle rigidity 461.58 13.90 253 53021 10265 34893392
Sedation 417.50 13.90 306 52968 20700 34882957
Agitation 405.73 13.90 468 52806 56931 34846726
Catatonia 380.50 13.90 175 53099 4850 34898807
Psychotic disorder 367.82 13.90 302 52972 24150 34879507
Delirium 348.95 13.90 381 52893 43610 34860047
Parkinsonism 343.97 13.90 191 53083 7947 34895710
Weight increased 316.04 13.90 533 52741 92500 34811157
Salivary hypersecretion 314.61 13.90 184 53090 8460 34895197
Tardive dyskinesia 309.78 13.90 159 53115 5631 34898026
Suicide attempt 298.45 13.90 332 52942 38784 34864873
Aggression 265.60 13.90 312 52962 38652 34865005
Hallucination, auditory 265.15 13.90 186 53088 11731 34891926
Hyperprolactinaemia 263.05 13.90 97 53177 1499 34902158
Sopor 259.78 13.90 185 53089 11951 34891706
Blood creatine phosphokinase increased 256.94 13.90 329 52945 44528 34859129
Tachycardia 224.41 13.90 436 52838 84336 34819321
Electrocardiogram QT prolonged 223.02 13.90 293 52981 40659 34862998
Antipsychotic drug level below therapeutic 222.38 13.90 98 53176 2449 34901208
Delusion 217.55 13.90 169 53105 12466 34891191
Drug interaction 204.74 13.90 781 52493 225165 34678492
Disinhibition 203.25 13.90 99 53175 3127 34900530
Somnolence 200.93 13.90 490 52784 110626 34793031
Obsessive-compulsive disorder 196.04 13.90 116 53158 5448 34898209
Schizophrenia 192.16 13.90 135 53139 8531 34895126
Dyskinesia 189.66 13.90 201 53073 22212 34881445
Emotional poverty 167.36 13.90 54 53220 544 34903113
Therapeutic product effect variable 165.71 13.90 79 53195 2377 34901280
Restlessness 150.72 13.90 190 53084 25292 34878365
Arthralgia 150.59 13.90 37 53237 170004 34733653
Euphoric mood 149.16 13.90 98 53176 5543 34898114
Intentional overdose 149.05 13.90 251 53023 43423 34860234
Rhabdomyolysis 147.75 13.90 323 52951 67840 34835817
Hypertonia 145.61 13.90 87 53187 4159 34899498
Increased appetite 140.26 13.90 105 53169 7324 34896333
Diarrhoea 132.42 13.90 246 53028 389666 34513991
Tremor 130.21 13.90 346 52928 82241 34821416
Fatigue 130.18 13.90 229 53045 370424 34533233
Rash 129.25 13.90 91 53183 222661 34680996
Dyspnoea 126.78 13.90 239 53035 376543 34527114
Psychomotor hyperactivity 120.40 13.90 107 53167 9515 34894142
Toxicity to various agents 118.35 13.90 610 52664 199752 34703905
Treatment noncompliance 111.52 13.90 173 53101 27927 34875730
Oculogyric crisis 110.01 13.90 52 53222 1534 34902123
Coma 109.98 13.90 226 53048 45452 34858205
Serotonin syndrome 105.94 13.90 141 53133 19792 34883865
Hyperthermia 104.23 13.90 103 53171 10474 34893183
Embolism venous 103.00 13.90 49 53225 1467 34902190
Granulocytopenia 102.64 13.90 83 53191 6484 34897173
Cogwheel rigidity 102.06 13.90 47 53227 1305 34902352
Dizziness 101.64 13.90 110 53164 218411 34685246
Headache 97.81 13.90 97 53177 200538 34703119
Hypothermia 97.36 13.90 100 53174 10648 34893009
Pneumonia aspiration 94.66 13.90 202 53072 41701 34861956
Oropharyngeal spasm 94.55 13.90 26 53248 141 34903516
Abnormal behaviour 93.92 13.90 150 53124 24819 34878838
Depressed level of consciousness 93.89 13.90 204 53070 42637 34861020
Myocarditis 93.86 13.90 110 53164 13572 34890085
Altered state of consciousness 93.73 13.90 143 53131 22750 34880907
Nausea 91.79 13.90 243 53031 339665 34563992
Sluggishness 91.05 13.90 59 53215 3258 34900399
Anaemia 87.42 13.90 138 53136 233197 34670460
Dysphagia 87.01 13.90 250 53024 62131 34841526
Mutism 86.50 13.90 37 53237 858 34902799
Pain in extremity 85.50 13.90 43 53231 126470 34777187
Cough 83.53 13.90 64 53210 150076 34753581
Pain 81.54 13.90 116 53158 204559 34699098
Delusion of grandeur 80.36 13.90 38 53236 1122 34902535
Torsade de pointes 80.09 13.90 75 53199 7134 34896523
Confusional state 78.87 13.90 430 52844 143730 34759927
Drooling 78.03 13.90 54 53220 3328 34900329
Spasmodic dysphonia 77.79 13.90 24 53250 206 34903451
Leukopenia 76.42 13.90 240 53034 62616 34841041
Malignant catatonia 76.20 13.90 24 53250 222 34903435
Paranoia 74.55 13.90 92 53182 11976 34891681
Torticollis 74.45 13.90 36 53238 1118 34902539
Febrile neutropenia 74.01 13.90 60 53214 136789 34766868
Ileus paralytic 73.66 13.90 66 53208 5931 34897726
Asthenia 72.63 13.90 167 53107 245084 34658573
Back pain 71.52 13.90 49 53225 121740 34781917
Overdose 70.30 13.90 300 52974 90759 34812898
Cardiac failure congestive 70.06 13.90 20 53254 83250 34820407
Disorientation 68.15 13.90 154 53120 33034 34870623
Myocardial infarction 68.11 13.90 51 53223 121034 34782623
Dysarthria 67.67 13.90 158 53116 34624 34869033
Hallucination 67.60 13.90 202 53072 51296 34852361
Antipsychotic drug level increased 67.16 13.90 52 53222 3813 34899844
Product dose omission issue 66.60 13.90 51 53223 119660 34783997
Nasopharyngitis 66.36 13.90 13 53261 69955 34833702
Cognitive disorder 65.57 13.90 139 53135 28554 34875103
Incorrect route of product administration 65.43 13.90 96 53178 14749 34888908
Protrusion tongue 64.08 13.90 20 53254 179 34903478
Death 63.10 13.90 353 52921 397696 34505961
Mania 62.81 13.90 75 53199 9436 34894221
Mental impairment 62.65 13.90 78 53196 10244 34893413
Infusion related reaction 62.00 13.90 5 53269 53052 34850605
Dyslipidaemia 61.27 13.90 66 53208 7422 34896235
Schizoaffective disorder 61.18 13.90 33 53241 1294 34902363
Opisthotonus 61.15 13.90 24 53250 443 34903214
Psychotic symptom 60.50 13.90 36 53238 1707 34901950
Persecutory delusion 59.07 13.90 41 53233 2539 34901118
Myoclonus 58.88 13.90 91 53183 14634 34889023
Autonomic nervous system imbalance 57.14 13.90 40 53234 2511 34901146
Prescribed overdose 56.07 13.90 75 53199 10572 34893085
Pruritus 55.96 13.90 81 53193 141900 34761757
Priapism 55.56 13.90 52 53222 4942 34898715
Social avoidant behaviour 54.34 13.90 42 53232 3072 34900585
Hyperreflexia 53.25 13.90 42 53232 3164 34900493
Stupor 52.66 13.90 40 53234 2851 34900806
Intestinal pseudo-obstruction 52.59 13.90 33 53241 1723 34901934
Accidental exposure to product by child 52.58 13.90 31 53243 1445 34902212
Speech disorder 52.52 13.90 119 53155 25567 34878090
Bradykinesia 52.12 13.90 45 53229 3848 34899809
Affective disorder 51.61 13.90 47 53227 4313 34899344
Leukaemia 51.34 13.90 48 53226 4555 34899102
Joint swelling 51.08 13.90 14 53260 59876 34843781
Visceral congestion 51.02 13.90 23 53251 607 34903050
Pneumonia 50.90 13.90 334 52940 362293 34541364
Peripheral swelling 50.21 13.90 27 53247 76514 34827143
Oromandibular dystonia 49.37 13.90 21 53253 480 34903177
White blood cell count increased 48.05 13.90 155 53119 40996 34862661
Trismus 46.50 13.90 35 53239 2460 34901197
Interstitial lung disease 45.88 13.90 21 53253 65261 34838396
Intentional product use issue 45.66 13.90 17 53257 59799 34843858
Erythema 45.43 13.90 41 53233 88739 34814918
Urinary retention 45.41 13.90 140 53134 36148 34867509
Psoriasis 44.40 13.90 4 53270 38808 34864849
Blood prolactin abnormal 44.40 13.90 24 53250 945 34902712
Chest discomfort 44.21 13.90 14 53260 54516 34849141
Rebound effect 44.15 13.90 38 53236 3236 34900421
Urticaria 43.94 13.90 20 53254 62357 34841300
Neutrophil count increased 43.81 13.90 87 53187 17059 34886598
Psychosexual disorder 43.50 13.90 13 53261 99 34903558
Abdominal pain upper 42.97 13.90 28 53246 71462 34832195
Water intoxication 42.37 13.90 18 53256 410 34903247
Encephalitis toxic 41.98 13.90 16 53258 272 34903385
Inappropriate antidiuretic hormone secretion 41.75 13.90 72 53202 12681 34890976
Cerebrovascular accident 41.25 13.90 41 53233 84770 34818887
Obesity 41.24 13.90 72 53202 12806 34890851
Sinusitis 40.74 13.90 7 53267 41395 34862262
Psychomotor retardation 40.59 13.90 38 53236 3612 34900045
Refusal of treatment by patient 40.55 13.90 44 53230 4988 34898669
Irritability 40.42 13.90 105 53169 24585 34879072
Eye movement disorder 40.30 13.90 40 53234 4087 34899570
Choking 38.93 13.90 43 53231 4972 34898685
Mental status changes 38.76 13.90 137 53137 37946 34865711
Anticholinergic syndrome 38.38 13.90 24 53250 1245 34902412
Influenza 38.10 13.90 14 53260 49652 34854005
Blood prolactin increased 38.04 13.90 27 53247 1733 34901924
Epistaxis 37.54 13.90 21 53253 58230 34845427
Peptostreptococcus infection 37.21 13.90 9 53265 26 34903631
Rhinalgia 37.21 13.90 22 53252 1031 34902626
Bradyphrenia 37.01 13.90 41 53233 4757 34898900
Self-injurious ideation 36.78 13.90 26 53248 1658 34901999
Herpes zoster 35.70 13.90 5 53269 34394 34869263
Chest pain 35.31 13.90 89 53185 126673 34776984
Abdominal discomfort 35.19 13.90 24 53250 59811 34843846
Waxy flexibility 35.00 13.90 11 53263 101 34903556
Asthma 34.49 13.90 11 53263 42645 34861012
Pyramidal tract syndrome 34.33 13.90 13 53261 217 34903440
Arthritis 33.87 13.90 4 53270 31342 34872315
Huntington's disease 33.50 13.90 9 53265 44 34903613
Injection site pain 33.48 13.90 9 53265 38996 34864661
Sedation complication 33.28 13.90 25 53249 1752 34901905
Coronary artery disease 33.23 13.90 16 53258 48289 34855368
Sinus tachycardia 32.82 13.90 78 53196 17282 34886375
Mental disorder 32.81 13.90 72 53202 15137 34888520
Oral discharge 32.58 13.90 11 53263 129 34903528
Product packaging issue 32.22 13.90 17 53257 637 34903020
Tic 32.13 13.90 26 53248 2032 34901625
Hypoaesthesia 31.88 13.90 28 53246 61416 34842241
Decreased appetite 31.74 13.90 138 53136 166254 34737403
Withdrawal syndrome 31.58 13.90 63 53211 12392 34891265
Angina pectoris 31.53 13.90 5 53269 31358 34872299
Disturbance in attention 31.44 13.90 99 53175 25846 34877811
Paraesthesia 31.22 13.90 31 53243 64141 34839516
Ascites 31.17 13.90 16 53258 46555 34857102
Body temperature increased 30.65 13.90 76 53198 17292 34886365
Sudden death 30.59 13.90 70 53204 15131 34888526
Weight decreased 30.22 13.90 152 53122 176149 34727508
Colitis ischaemic 30.17 13.90 43 53231 6432 34897225
Seizure 29.97 13.90 267 53007 104590 34799067
Compulsive sexual behaviour 29.73 13.90 12 53262 239 34903418
Schizoaffective disorder bipolar type 29.72 13.90 10 53264 116 34903541
Oedema peripheral 29.72 13.90 89 53185 119723 34783934
Haemorrhage 29.69 13.90 21 53253 51349 34852308
Leukocytosis 29.32 13.90 92 53182 23973 34879684
Porphyria acute 29.16 13.90 13 53261 334 34903323
Medication error 28.67 13.90 95 53179 25470 34878187
Generalised tonic-clonic seizure 28.66 13.90 84 53190 21090 34882567
Neuropathy peripheral 28.56 13.90 52 53222 83211 34820446
Patient restraint 28.31 13.90 9 53265 86 34903571
Haematochezia 28.26 13.90 18 53256 46516 34857141
Epilepsy 27.88 13.90 84 53190 21411 34882246
Atrial fibrillation 27.51 13.90 95 53179 122298 34781359
Rapid eye movement sleep behaviour disorder 27.38 13.90 10 53264 150 34903507
Lymphocyte count abnormal 27.34 13.90 19 53255 1179 34902478
Diet refusal 27.29 13.90 12 53262 298 34903359
Bruxism 27.26 13.90 22 53252 1713 34901944
Acute myocardial infarction 27.24 13.90 25 53249 53694 34849963
HIV peripheral neuropathy 27.00 13.90 7 53267 29 34903628
Acute kidney injury 26.69 13.90 317 52957 304671 34598986
Posturing 26.65 13.90 14 53260 520 34903137
Stomatitis 26.44 13.90 16 53258 42498 34861159
Musculoskeletal pain 26.28 13.90 8 53266 31955 34871702
Agranulocytosis 26.25 13.90 88 53186 23733 34879924
Thrombosis 26.16 13.90 23 53251 50435 34853222
Resting tremor 26.08 13.90 15 53259 667 34902990
Muscle contractions involuntary 25.96 13.90 22 53252 1834 34901823
Galactorrhoea 25.94 13.90 13 53261 437 34903220
Pancytopenia 25.57 13.90 68 53206 95089 34808568
Blunted affect 25.57 13.90 12 53262 348 34903309
Drug level increased 25.57 13.90 83 53191 22013 34881644
Sexual dysfunction 25.26 13.90 39 53235 6264 34897393
Apathy 25.17 13.90 41 53233 6891 34896766
Completed suicide 25.05 13.90 244 53030 97924 34805733
Tachypnoea 25.02 13.90 73 53201 18279 34885378
Hyperkalaemia 25.00 13.90 42 53232 69347 34834310
Exhibitionism 25.00 13.90 7 53267 41 34903616
Intentional product misuse 24.83 13.90 136 53138 45475 34858182
Foetal alcohol syndrome 24.58 13.90 9 53265 136 34903521
Antipsychotic drug level above therapeutic 24.55 13.90 18 53256 1215 34902442
Prostate cancer 24.54 13.90 15 53259 39634 34864023
Cytomegalovirus infection 24.47 13.90 5 53269 26130 34877527
Muscle contracture 24.41 13.90 18 53256 1226 34902431
Hyponatraemia 24.36 13.90 212 53062 82479 34821178
Postoperative respiratory failure 24.35 13.90 9 53265 140 34903517
Faecaloma 24.02 13.90 35 53239 5342 34898315
Gastrointestinal haemorrhage 23.95 13.90 63 53211 88414 34815243
Coma scale abnormal 23.86 13.90 30 53244 3978 34899679
Urinary incontinence 23.77 13.90 73 53201 18801 34884856
Colitis 23.76 13.90 14 53260 37736 34865921
Pneumonitis 23.64 13.90 11 53263 33867 34869790
Drug withdrawal syndrome 23.40 13.90 75 53199 19759 34883898
Renal impairment 22.86 13.90 71 53203 94442 34809215
Malignant neoplasm progression 22.85 13.90 64 53210 87982 34815675
Multiple organ dysfunction syndrome 22.70 13.90 52 53222 76514 34827143
Psychiatric decompensation 22.48 13.90 25 53249 2912 34900745
Dextrocardia 22.28 13.90 8 53266 114 34903543
Aspiration 22.20 13.90 54 53220 12140 34891517
Vascular stenosis 22.13 13.90 9 53265 183 34903474
Dyspnoea exertional 22.11 13.90 20 53254 43259 34860398
Dry skin 22.08 13.90 10 53264 31277 34872380
Pharyngeal dystonia 21.74 13.90 7 53267 70 34903587
Suicidal ideation 21.70 13.90 120 53154 40268 34863389
Fluid retention 21.62 13.90 7 53267 26880 34876777
Drug withdrawal syndrome neonatal 21.40 13.90 27 53247 3592 34900065
Blood pressure fluctuation 21.34 13.90 6 53268 25243 34878414
Chorea 21.30 13.90 16 53258 1121 34902536
Parkinsonian gait 21.28 13.90 12 53262 514 34903143
Physical assault 21.20 13.90 16 53258 1129 34902528
Skin lesion 20.98 13.90 4 53270 21957 34881700
Malaise 20.82 13.90 182 53092 185643 34718014
Hallucinations, mixed 20.78 13.90 23 53251 2666 34900991
Unevaluable event 20.64 13.90 12 53262 32578 34871079
Drug ineffective 20.63 13.90 871 52403 455880 34447777
Unresponsive to stimuli 20.60 13.90 90 53184 27479 34876178
Drug ineffective for unapproved indication 20.53 13.90 81 53193 23634 34880023
Myalgia 20.47 13.90 63 53211 84047 34819610
Cross sensitivity reaction 20.45 13.90 17 53257 1380 34902277
Nasal congestion 20.40 13.90 5 53269 23052 34880605
Tongue spasm 20.39 13.90 6 53268 43 34903614
Cardio-respiratory arrest 20.25 13.90 149 53125 55124 34848533
Sexual abuse 20.22 13.90 8 53266 151 34903506
Pneumocystis jirovecii pneumonia 20.13 13.90 3 53271 19707 34883950
Drop attacks 20.13 13.90 12 53262 571 34903086
Disease progression 19.77 13.90 91 53183 107986 34795671
Reduced facial expression 19.66 13.90 15 53259 1076 34902581
Dysgeusia 19.44 13.90 8 53266 26489 34877168
Type 2 diabetes mellitus 19.26 13.90 61 53213 15971 34887686
Flight of ideas 19.14 13.90 10 53264 367 34903290
Perseveration 19.05 13.90 7 53267 107 34903550
Cardiac arrest 18.95 13.90 227 53047 95932 34807725
Abdominal distension 18.77 13.90 38 53236 58454 34845203
Pulmonary fibrosis 18.34 13.90 3 53271 18393 34885264
Snoring 18.28 13.90 24 53250 3322 34900335
Hyperhidrosis 18.26 13.90 186 53088 75506 34828151
Polydipsia 18.24 13.90 26 53248 3889 34899768
Negativism 18.15 13.90 10 53264 409 34903248
Inappropriate affect 18.06 13.90 12 53262 691 34902966
Nephrolithiasis 18.05 13.90 12 53262 30321 34873336
Echolalia 18.05 13.90 9 53265 299 34903358
Haemoglobin decreased 18.00 13.90 109 53165 120663 34782994
Thinking abnormal 17.97 13.90 33 53241 6104 34897553
Wheezing 17.93 13.90 22 53252 41380 34862277
Floppy iris syndrome 17.81 13.90 9 53265 308 34903349
Antidepressant drug level increased 17.75 13.90 7 53267 131 34903526
Wrong patient received product 17.64 13.90 21 53253 2633 34901024
Mydriasis 17.62 13.90 36 53238 7201 34896456
Accidental exposure to product 17.53 13.90 51 53223 12751 34890906
Wolff-Parkinson-White syndrome 17.51 13.90 8 53266 218 34903439
Tension 17.49 13.90 19 53255 2156 34901501
Hypersexuality 17.49 13.90 16 53258 1477 34902180
Gaze palsy 17.47 13.90 17 53257 1695 34901962
Gastric infection 17.43 13.90 15 53259 1277 34902380
Syncope 17.32 13.90 76 53198 91375 34812282
Substance-induced psychotic disorder 17.26 13.90 17 53257 1721 34901936
Localised infection 17.24 13.90 3 53271 17584 34886073
Judgement impaired 17.08 13.90 11 53263 601 34903056
Heart rate decreased 17.03 13.90 14 53260 31731 34871926
Mumps 17.01 13.90 6 53268 81 34903576
Night sweats 16.92 13.90 3 53271 17349 34886308
Hypersensitivity 16.86 13.90 43 53231 60992 34842665
Speech sound disorder 16.70 13.90 7 53267 154 34903503
Intestinal obstruction 16.67 13.90 74 53200 22748 34880909
Dysphoria 16.61 13.90 19 53255 2283 34901374
Hyperventilation 16.59 13.90 21 53253 2803 34900854
Bronchitis 16.45 13.90 24 53250 41939 34861718
Electrocardiogram J wave 16.43 13.90 4 53270 12 34903645
Acute psychosis 16.42 13.90 17 53257 1826 34901831
Inappropriate schedule of product administration 16.37 13.90 45 53229 62251 34841406
Chronic obstructive pulmonary disease 16.37 13.90 31 53243 48887 34854770
Labile blood pressure 16.34 13.90 11 53263 648 34903009
Sexually inappropriate behaviour 16.29 13.90 10 53264 502 34903155
Blood pressure increased 16.21 13.90 74 53200 88028 34815629
Osmotic demyelination syndrome 15.95 13.90 12 53262 843 34902814
Anxiety 15.93 13.90 226 53048 99202 34804455
Pleural effusion 15.91 13.90 67 53207 81479 34822178
Gender dysphoria 15.90 13.90 5 53269 46 34903611
Hyperammonaemia 15.89 13.90 32 53242 6335 34897322
Full blood count decreased 15.85 13.90 4 53270 18084 34885573
Haemoptysis 15.80 13.90 18 53256 34988 34868669
Colitis ulcerative 15.80 13.90 3 53271 16517 34887140
Infection 15.77 13.90 78 53196 90837 34812820
Staring 15.76 13.90 15 53259 1455 34902202
Colectomy total 15.73 13.90 7 53267 179 34903478
Antisocial behaviour 15.69 13.90 9 53265 398 34903259
Cerebrovascular stenosis 15.69 13.90 6 53268 103 34903554
Gastrooesophageal reflux disease 15.55 13.90 21 53253 37903 34865754
Gout 15.50 13.90 5 53269 19248 34884409
Foetal arrhythmia 15.43 13.90 6 53268 108 34903549
Flushing 15.38 13.90 16 53258 32404 34871253
Posture abnormal 15.35 13.90 18 53256 2221 34901436
Visual acuity reduced 15.30 13.90 3 53271 16146 34887511
Delusional disorder, unspecified type 15.25 13.90 11 53263 724 34902933
Swollen tongue 15.25 13.90 53 53221 14552 34889105
Hallucination, olfactory 15.05 13.90 7 53267 199 34903458
Miosis 15.04 13.90 40 53234 9495 34894162
Anaphylactic shock 15.02 13.90 3 53271 15938 34887719
Fungal infection 15.02 13.90 3 53271 15932 34887725
Rabbit syndrome 14.98 13.90 4 53270 19 34903638
Musculoskeletal stiffness 14.97 13.90 122 53152 46558 34857099
COVID-19 14.96 13.90 64 53210 77486 34826171
Haematuria 14.83 13.90 34 53240 50032 34853625
Hypokinesia 14.77 13.90 38 53236 8842 34894815
Proteinuria 14.73 13.90 5 53269 18637 34885020
Globulins decreased 14.61 13.90 7 53267 213 34903444
Granulomatous liver disease 14.58 13.90 10 53264 607 34903050
Cholelithiasis 14.55 13.90 7 53267 21141 34882516
Antisocial personality disorder 14.49 13.90 5 53269 63 34903594
Nasal discomfort 14.47 13.90 15 53259 1613 34902044
Adactyly 14.41 13.90 5 53269 64 34903593
Incoherent 14.39 13.90 25 53249 4427 34899230
Exposure to extreme temperature 14.39 13.90 3 53271 3 34903654
Bacteraemia 14.39 13.90 6 53268 19711 34883946
Abdominal pain 14.29 13.90 170 53104 163448 34740209
Impaired healing 14.21 13.90 3 53271 15331 34888326
Impulsive behaviour 14.19 13.90 17 53257 2145 34901512
Bone pain 14.00 13.90 7 53267 20679 34882978
Differential white blood cell count abnormal 13.98 13.90 14 53260 1445 34902212
Compulsions 13.97 13.90 7 53267 235 34903422
Osteoarthritis 13.95 13.90 7 53267 20635 34883022
Coprolalia 13.93 13.90 4 53270 26 34903631
Cyanosis 13.92 13.90 47 53227 12717 34890940

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuroleptic malignant syndrome 3429.85 13.64 1223 80007 26336 79636822
Extrapyramidal disorder 3006.26 13.64 1055 80175 21624 79641534
Intentional self-injury 1436.84 13.64 688 80542 31731 79631427
Dystonia 1024.15 13.64 479 80751 20920 79642238
Akathisia 842.70 13.64 362 80868 12897 79650261
Catatonia 810.15 13.64 313 80917 8443 79654715
Muscle rigidity 787.63 13.64 391 80839 19491 79643667
Agitation 707.01 13.64 675 80555 99040 79564118
Drug interaction 624.20 13.64 1332 79898 413851 79249307
Salivary hypersecretion 576.00 13.64 284 80946 13940 79649218
Psychotic disorder 574.64 13.64 414 80816 40988 79622170
Sopor 573.40 13.64 379 80851 32631 79630527
Delirium 567.98 13.64 556 80674 84071 79579087
Parkinsonism 543.30 13.64 287 80943 16297 79646861
Sedation 525.06 13.64 430 80800 51465 79611693
Hyperprolactinaemia 500.63 13.64 186 81044 4490 79658668
Hallucination, auditory 468.31 13.64 281 80949 20412 79642746
Delusion 461.33 13.64 277 80953 20146 79643012
Aggression 455.19 13.64 393 80837 50565 79612593
Tardive dyskinesia 433.77 13.64 213 81017 10358 79652800
Somnolence 397.17 13.64 800 80430 238181 79424977
Arthralgia 376.58 13.64 65 81165 571738 79091420
Electrocardiogram QT prolonged 372.90 13.64 460 80770 89926 79573232
Blood creatine phosphokinase increased 361.31 13.64 389 80841 65701 79597457
Weight increased 357.50 13.64 838 80392 276548 79386610
Intentional overdose 334.65 13.64 473 80757 105487 79557671
Suicide attempt 333.94 13.64 417 80813 82515 79580643
Psychomotor hyperactivity 320.83 13.64 205 81025 16644 79646514
Schizophrenia 301.82 13.64 191 81039 15249 79647909
Dyskinesia 299.86 13.64 294 80936 44479 79618679
Tachycardia 292.58 13.64 593 80637 177175 79485983
Rhabdomyolysis 284.55 13.64 432 80798 102699 79560459
Pain 281.71 13.64 186 81044 703616 78959542
Fatigue 265.19 13.64 336 80894 929391 78733767
Tremor 261.80 13.64 552 80678 169531 79493627
Headache 257.23 13.64 176 81054 653596 79009562
Restlessness 252.90 13.64 273 80957 46219 79616939
Coma 246.25 13.64 399 80831 100250 79562908
Hypertonia 239.21 13.64 126 81104 7106 79656052
Hypothermia 228.93 13.64 188 81042 22558 79640600
Rash 224.35 13.64 158 81072 578200 79084958
Joint swelling 218.06 13.64 21 81209 288625 79374533
Abnormal behaviour 208.91 13.64 220 81010 36201 79626957
Sluggishness 207.48 13.64 111 81119 6461 79656697
Toxicity to various agents 198.28 13.64 902 80328 420638 79242520
Hallucination 197.69 13.64 331 80899 85414 79577744
Depressed level of consciousness 196.60 13.64 353 80877 96299 79566859
Infusion related reaction 196.50 13.64 9 81221 230228 79432930
Hyperthermia 189.78 13.64 153 81077 17884 79645274
Rheumatoid arthritis 188.88 13.64 5 81225 208465 79454693
Oculogyric crisis 188.82 13.64 81 81149 2871 79660287
Cogwheel rigidity 188.56 13.64 82 81148 3006 79660152
Pain in extremity 188.46 13.64 68 81162 364470 79298688
Torsade de pointes 182.68 13.64 154 81076 19158 79644000
Embolism venous 178.63 13.64 87 81143 4152 79659006
Altered state of consciousness 177.34 13.64 221 81009 43601 79619557
Overdose 176.32 13.64 498 80732 183708 79479450
Pneumonia aspiration 174.07 13.64 273 80957 66694 79596464
Confusional state 173.61 13.64 712 80518 317285 79345873
Mutism 171.46 13.64 71 81159 2301 79660857
Dysarthria 165.23 13.64 268 80962 67354 79595804
Treatment noncompliance 162.92 13.64 232 80998 52036 79611122
Granulocytopenia 162.37 13.64 116 81114 11315 79651843
Nasopharyngitis 162.17 13.64 31 81199 253850 79409308
Bradykinesia 160.94 13.64 101 81129 7942 79655216
Dyspnoea 155.99 13.64 408 80822 856617 78806541
Paranoia 155.72 13.64 141 81089 19291 79643867
Emotional poverty 155.62 13.64 51 81179 836 79662322
Torticollis 154.33 13.64 66 81164 2321 79660837
Peripheral swelling 154.11 13.64 42 81188 269575 79393583
Serotonin syndrome 154.00 13.64 209 81021 44818 79618340
Dysphagia 153.70 13.64 366 80864 121770 79541388
Nausea 150.04 13.64 489 80741 956707 78706451
Diarrhoea 148.46 13.64 435 80795 880054 78783104
Pruritus 147.39 13.64 112 81118 394536 79268622
Sinusitis 143.01 13.64 16 81214 195485 79467673
Ileus paralytic 142.14 13.64 100 81130 9520 79653638
Abdominal discomfort 139.68 13.64 41 81189 250686 79412472
Drooling 135.30 13.64 81 81149 5853 79657305
Disorientation 133.69 13.64 234 80996 62542 79600616
Arthropathy 130.80 13.64 14 81216 177097 79486061
Persecutory delusion 130.43 13.64 74 81156 4835 79658323
Swelling 127.17 13.64 32 81198 216679 79446479
Mania 126.13 13.64 122 81108 18138 79645020
Myocarditis 125.90 13.64 132 81098 21601 79641557
Psychomotor retardation 122.09 13.64 77 81153 6107 79657051
Dizziness 121.75 13.64 219 81011 526222 79136936
Cough 117.73 13.64 120 81110 366669 79296489
Psychotic symptom 115.59 13.64 56 81174 2641 79660517
Suicidal ideation 111.81 13.64 243 80987 76097 79587061
Alopecia 111.50 13.64 48 81182 231307 79431851
Mental impairment 110.95 13.64 116 81114 18920 79644238
Back pain 110.13 13.64 89 81141 304091 79359067
Hyperreflexia 107.54 13.64 80 81150 8305 79654853
Stupor 107.53 13.64 74 81156 6798 79656360
Cognitive disorder 106.33 13.64 226 81004 69700 79593458
Galactorrhoea 105.14 13.64 58 81172 3588 79659570
Urinary retention 103.99 13.64 198 81032 56432 79606726
Hypersensitivity 100.96 13.64 72 81158 262167 79400991
Leukopenia 100.83 13.64 304 80926 116209 79546949
Drug intolerance 99.76 13.64 74 81156 264045 79399113
Accidental exposure to product by child 99.67 13.64 52 81178 2874 79660284
Schizoaffective disorder 99.27 13.64 47 81183 2105 79661053
Malignant catatonia 99.10 13.64 31 81199 434 79662724
Drug abuse 97.22 13.64 375 80855 162316 79500842
Urticaria 96.54 13.64 34 81196 185167 79477991
Antipsychotic drug level below therapeutic 96.10 13.64 39 81191 1199 79661959
Product dose omission issue 95.24 13.64 68 81162 247469 79415689
Social avoidant behaviour 95.18 13.64 60 81170 4754 79658404
Bradyphrenia 94.81 13.64 82 81148 10558 79652600
Delusion of grandeur 93.92 13.64 40 81190 1392 79661766
Arthritis 93.27 13.64 6 81224 114874 79548284
Abdominal pain upper 92.15 13.64 57 81173 223762 79439396
Contraindicated product administered 90.99 13.64 24 81206 157514 79505644
Injection site pain 89.19 13.64 13 81217 129825 79533333
Mental status changes 88.92 13.64 205 81025 66754 79596404
Oromandibular dystonia 87.90 13.64 35 81195 1023 79662135
Blood prolactin increased 86.93 13.64 53 81177 3958 79659200
Opisthotonus 86.83 13.64 31 81199 665 79662493
Drug level increased 85.96 13.64 149 81081 39502 79623656
Intentional product misuse 83.93 13.64 250 80980 94915 79568243
Wound 83.71 13.64 10 81220 116169 79546989
Antipsychotic drug level increased 83.57 13.64 60 81170 5897 79657261
Asthenia 80.82 13.64 260 80970 511429 79151729
Autonomic nervous system imbalance 79.95 13.64 53 81177 4577 79658581
Speech disorder 79.36 13.64 173 81057 54272 79608886
Encephalitis autoimmune 78.80 13.64 41 81189 2253 79660905
Leukocytosis 78.63 13.64 151 81079 43304 79619854
Inappropriate antidiuretic hormone secretion 77.89 13.64 114 81116 26199 79636959
Negativism 76.79 13.64 30 81200 833 79662325
Hyponatraemia 76.32 13.64 371 80859 177477 79485681
Cardiac arrest 76.02 13.64 362 80868 171734 79491424
Oropharyngeal spasm 75.99 13.64 25 81205 415 79662743
White blood cell count increased 75.48 13.64 206 81024 74427 79588731
Asthma 75.36 13.64 22 81208 135073 79528085
Psoriasis 74.79 13.64 4 81226 89583 79573575
Obsessive-compulsive disorder 74.79 13.64 56 81174 5871 79657287
Chest discomfort 74.27 13.64 24 81206 138020 79525138
Spasmodic dysphonia 74.05 13.64 22 81208 256 79662902
Priapism 74.02 13.64 50 81180 4455 79658703
Disinhibition 74.01 13.64 41 81189 2557 79660601
Neutrophil count increased 73.81 13.64 118 81112 29278 79633880
Myoclonus 72.17 13.64 113 81117 27547 79635611
Mental disorder 70.98 13.64 120 81110 31182 79631976
Discomfort 70.91 13.64 20 81210 125597 79537561
Refusal of examination 70.24 13.64 20 81210 198 79662960
Protrusion tongue 67.67 13.64 23 81207 424 79662734
Impaired healing 67.13 13.64 6 81224 87649 79575509
Herpes zoster 67.08 13.64 8 81222 93075 79570083
Anaemia 66.88 13.64 231 80999 444784 79218374
Musculoskeletal pain 66.37 13.64 12 81218 102342 79560816
Irritability 66.05 13.64 136 81094 41008 79622150
Lethargy 65.56 13.64 207 81023 81085 79582073
Influenza 65.49 13.64 25 81205 129581 79533577
Waxy flexibility 65.08 13.64 20 81210 263 79662895
Disturbance in attention 64.67 13.64 153 81077 50648 79612510
Paraesthesia 64.50 13.64 51 81179 176272 79486886
Hypoaesthesia 64.21 13.64 53 81177 179299 79483859
Visceral congestion 63.68 13.64 27 81203 929 79662229
Echolalia 63.15 13.64 21 81209 361 79662797
Stomatitis 62.32 13.64 36 81194 146721 79516437
Cardiac failure congestive 61.81 13.64 34 81196 142368 79520790
Euphoric mood 61.77 13.64 56 81174 7670 79655488
Osteoarthritis 61.71 13.64 8 81222 87301 79575857
Pleurothotonus 61.70 13.64 36 81194 2480 79660678
Sudden death 61.58 13.64 94 81136 22417 79640741
Chest pain 61.13 13.64 122 81108 282182 79380976
Intestinal pseudo-obstruction 60.48 13.64 36 81194 2573 79660585
Seizure 59.43 13.64 362 80868 188472 79474686
Helicobacter infection 58.54 13.64 3 81227 69701 79593457
Unresponsive to stimuli 58.42 13.64 156 81074 55632 79607526
Miosis 58.13 13.64 76 81154 15713 79647445
Weight decreased 57.76 13.64 178 81052 355020 79308138
Generalised tonic-clonic seizure 56.71 13.64 133 81097 43777 79619381
Refusal of treatment by patient 56.39 13.64 57 81173 8934 79654224
Hypernatraemia 53.89 13.64 70 81160 14381 79648777
Injection site erythema 53.30 13.64 8 81222 78189 79584969
Erythema 53.20 13.64 91 81139 223199 79439959
Contusion 51.98 13.64 45 81185 148731 79514427
Bradycardia 51.96 13.64 274 80956 135283 79527875
Hallucinations, mixed 51.26 13.64 48 81182 6851 79656307
Stereotypy 50.96 13.64 23 81207 922 79662236
Malaise 50.79 13.64 292 80938 489577 79173581
Electrocardiogram J wave 50.65 13.64 12 81218 52 79663106
Therapeutic product effect decreased 49.83 13.64 56 81174 163807 79499351
Nasal congestion 49.58 13.64 9 81221 76543 79586615
Myocardial reperfusion injury 48.45 13.64 13 81217 101 79663057
Pulmonary embolism 48.38 13.64 320 80910 171334 79491824
Rebound effect 47.51 13.64 47 81183 7179 79655979
Bronchitis 47.51 13.64 38 81192 130606 79532552
Intentional product use issue 47.34 13.64 51 81179 152061 79511097
Affective disorder 47.24 13.64 50 81180 8269 79654889
Behaviour disorder 47.06 13.64 44 81186 6269 79656889
Epistaxis 46.43 13.64 28 81202 111487 79551671
Febrile neutropenia 45.68 13.64 105 81125 230894 79432264
Hallucination, visual 45.43 13.64 102 81128 32627 79630531
Incorrect route of product administration 45.33 13.64 106 81124 34823 79628335
Product packaging issue 45.13 13.64 23 81207 1210 79661948
Pericarditis 45.06 13.64 25 81205 104211 79558947
Myalgia 44.82 13.64 75 81155 185566 79477592
Colitis ischaemic 44.67 13.64 66 81164 15293 79647865
Trismus 44.44 13.64 40 81190 5427 79657731
Inflammation 44.27 13.64 20 81210 93733 79569425
Encephalitis toxic 44.06 13.64 15 81215 278 79662880
Infection 43.78 13.64 115 81115 241597 79421561
Eye movement disorder 43.46 13.64 47 81183 7964 79655194
Diet refusal 43.20 13.64 20 81210 851 79662307
Interstitial lung disease 43.18 13.64 31 81199 112569 79550589
Self-injurious ideation 42.87 13.64 33 81197 3605 79659553
Clonus 42.23 13.64 43 81187 6797 79656361
Nuchal rigidity 41.60 13.64 21 81209 1083 79662075
Parkinsonian gait 41.58 13.64 20 81210 928 79662230
Respiratory failure 41.55 13.64 321 80909 180590 79482568
Fluid retention 41.52 13.64 10 81220 69799 79593359
Gestational diabetes 41.50 13.64 41 81189 6252 79656906
Cardio-respiratory arrest 41.35 13.64 219 81011 108291 79554867
Rapid eye movement sleep behaviour disorder 40.76 13.64 16 81214 450 79662708
Drug withdrawal syndrome 40.38 13.64 101 81129 34617 79628541
Coma scale abnormal 40.38 13.64 47 81183 8631 79654527
Thinking abnormal 40.37 13.64 58 81172 13103 79650055
Agranulocytosis 40.35 13.64 119 81111 44911 79618247
Impulsive behaviour 40.20 13.64 29 81201 2871 79660287
Ill-defined disorder 40.04 13.64 9 81221 65866 79597292
Increased appetite 40.03 13.64 55 81175 11923 79651235
Withdrawal syndrome 39.89 13.64 86 81144 26768 79636390
Huntington's disease 39.81 13.64 8 81222 12 79663146
Blunted affect 39.76 13.64 16 81214 481 79662677
Parotitis 39.36 13.64 27 81203 2467 79660691
Folliculitis 39.31 13.64 5 81225 55375 79607783
Oedema peripheral 39.18 13.64 129 81101 252159 79410999
Reduced facial expression 39.13 13.64 28 81202 2737 79660421
Akinesia 38.93 13.64 30 81200 3282 79659876
Hyperammonaemic encephalopathy 38.90 13.64 35 81195 4747 79658411
Apallic syndrome 38.20 13.64 19 81211 949 79662209
Choking 38.11 13.64 54 81176 12047 79651111
Blood pressure increased 37.93 13.64 101 81129 211259 79451899
Haematochezia 37.92 13.64 21 81209 87624 79575534
Psychosexual disorder 37.83 13.64 11 81219 118 79663040
Therapeutic product effect variable 37.14 13.64 24 81206 1985 79661173
Tachypnoea 37.00 13.64 93 81137 31970 79631188
Toxic epidermal necrolysis 36.37 13.64 114 81116 44467 79618691
Psychiatric decompensation 36.24 13.64 31 81199 3932 79659226
Neutropenia 36.20 13.64 450 80780 287260 79375898
Gastrooesophageal reflux disease 35.84 13.64 32 81198 104214 79558944
Flushing 35.58 13.64 23 81207 88245 79574913
Myocardial infarction 35.35 13.64 85 81145 184044 79479114
Wheezing 35.32 13.64 40 81190 116624 79546534
Resting tremor 35.29 13.64 21 81209 1500 79661658
Apathy 35.23 13.64 54 81176 12923 79650235
Sexually inappropriate behaviour 35.01 13.64 15 81215 530 79662628
Polydipsia 34.52 13.64 38 81192 6567 79656591
Hepatic enzyme increased 34.51 13.64 85 81145 182525 79480633
Sinus tachycardia 34.47 13.64 99 81131 36809 79626349
Dementia 34.39 13.64 77 81153 24582 79638576
Sexual dysfunction 34.39 13.64 41 81189 7722 79655436
Injection site reaction 34.29 13.64 7 81223 54778 79608380
Flight of ideas 34.26 13.64 17 81213 845 79662313
Accidental exposure to product 34.23 13.64 89 81141 31233 79631925
Feeling guilty 34.14 13.64 17 81213 851 79662307
Night sweats 34.00 13.64 6 81224 52089 79611069
Aspiration 33.97 13.64 68 81162 20090 79643068
Compulsive sexual behaviour 33.94 13.64 12 81218 250 79662908
Pulmonary fibrosis 33.83 13.64 3 81227 44109 79619049
Bruxism 33.80 13.64 30 81200 3996 79659162
Oral discharge 33.67 13.64 12 81218 256 79662902
Distractibility 33.54 13.64 16 81214 729 79662429
Muscle contractions involuntary 33.51 13.64 29 81201 3736 79659422
Illness 33.50 13.64 4 81226 46507 79616651
Hypersexuality 33.37 13.64 21 81209 1659 79661499
Dyspnoea exertional 33.35 13.64 24 81206 87049 79576109
Chorea 33.12 13.64 24 81206 2393 79660765
Illogical thinking 33.09 13.64 9 81221 74 79663084
Drug ineffective for unapproved indication 32.97 13.64 121 81109 51117 79612041
Dry skin 32.90 13.64 14 81216 67981 79595177
Tic 32.83 13.64 26 81204 2960 79660198
Respiratory depression 32.79 13.64 81 81149 27549 79635609
Peptostreptococcus infection 32.47 13.64 9 81221 80 79663078
Blood pressure fluctuation 32.21 13.64 14 81216 67131 79596027
Eosinophil count decreased 31.94 13.64 27 81203 3369 79659789
Burning sensation 31.87 13.64 10 81220 58622 79604536
Mobility decreased 31.72 13.64 47 81183 122128 79541030
Differential white blood cell count abnormal 31.64 13.64 22 81208 2055 79661103
Multiple sclerosis relapse 31.17 13.64 5 81225 46528 79616630
Haemoglobin urine 31.15 13.64 10 81220 153 79663005
Somatic symptom disorder of pregnancy 31.09 13.64 9 81221 95 79663063
Posturing 31.05 13.64 17 81213 1036 79662122
Patient restraint 31 13.64 9 81221 96 79663062
Urinary incontinence 31 13.64 102 81128 40807 79622351
Acute psychosis 30.90 13.64 29 81201 4151 79659007
Throat irritation 30.82 13.64 3 81227 40943 79622215
Grandiosity 30.75 13.64 14 81216 573 79662585
Hyperhidrosis 30.55 13.64 261 80969 151231 79511927
Pyramidal tract syndrome 30.52 13.64 14 81216 583 79662575
Anticholinergic syndrome 30.50 13.64 27 81203 3584 79659574
Lower respiratory tract infection 30.45 13.64 53 81177 129167 79533991
Lymphocyte count abnormal 30.39 13.64 19 81211 1484 79661674
Cerebrovascular accident 30.36 13.64 71 81159 155221 79507937
Epilepsy 30.18 13.64 101 81129 40759 79622399
Floppy iris syndrome 30.13 13.64 12 81218 351 79662807
Brain injury 29.97 13.64 47 81183 11470 79651688
Drug hypersensitivity 29.96 13.64 180 81050 298736 79364422
Cannabinoid hyperemesis syndrome 29.95 13.64 8 81222 61 79663097
Tonic clonic movements 29.93 13.64 22 81208 2242 79660916
Granulomatous liver disease 29.88 13.64 18 81212 1315 79661843
Faecaloma 29.83 13.64 47 81183 11517 79651641
Electroencephalogram abnormal 29.69 13.64 32 81198 5402 79657756
Hypoxic-ischaemic encephalopathy 29.34 13.64 38 81192 7782 79655376
Psychiatric symptom 29.28 13.64 36 81194 6999 79656159
Mydriasis 29.12 13.64 59 81171 17584 79645574
Rhinalgia 29.06 13.64 22 81208 2345 79660813
Staring 29.02 13.64 23 81207 2622 79660536
Sinus bradycardia 28.89 13.64 73 81157 25174 79637984
HIV peripheral neuropathy 28.73 13.64 7 81223 35 79663123
Dementia with Lewy bodies 28.72 13.64 15 81215 831 79662327
Treatment failure 28.70 13.64 84 81146 170402 79492756
Pain in jaw 28.67 13.64 6 81224 46145 79617013
Medication error 28.56 13.64 142 81088 68500 79594658
Encephalopathy 28.45 13.64 140 81090 67257 79595901
Rash pruritic 28.42 13.64 19 81211 71610 79591548
Hypokinesia 28.26 13.64 61 81169 18999 79644159
Palpitations 27.99 13.64 54 81176 126556 79536602
Substance-induced psychotic disorder 27.95 13.64 25 81205 3364 79659794
Myelosuppression 27.74 13.64 4 81226 40292 79622866
Negative symptoms in schizophrenia 27.72 13.64 9 81221 143 79663015
Eye pain 27.65 13.64 3 81227 37575 79625583
Communication disorder 27.63 13.64 27 81203 4063 79659095
Antidepressant drug level increased 27.59 13.64 12 81218 440 79662718
Oropharyngeal pain 27.49 13.64 43 81187 109310 79553848
Schizoaffective disorder bipolar type 27.28 13.64 10 81220 232 79662926
Muscle contracture 27.26 13.64 21 81209 2296 79660862
Water intoxication 27.06 13.64 14 81216 760 79662398
Completed suicide 26.97 13.64 375 80855 245392 79417766
Hyporesponsive to stimuli 26.95 13.64 20 81210 2068 79661090
Delusional disorder, unspecified type 26.93 13.64 14 81216 768 79662390
Stress 26.70 13.64 25 81205 79587 79583571
Muscular weakness 26.47 13.64 80 81150 160649 79502509
Osteoporosis 26.40 13.64 11 81219 54101 79609057
Speech sound disorder 26.13 13.64 7 81223 54 79663104
Dysphoria 26.08 13.64 28 81202 4706 79658452
Bursitis 26.02 13.64 3 81227 35841 79627317
Tension 25.95 13.64 27 81203 4377 79658781
Cardiomyopathy alcoholic 25.91 13.64 7 81223 56 79663102
Vulvovaginal candidiasis 25.75 13.64 21 81209 2493 79660665
Injection site swelling 25.68 13.64 8 81222 47124 79616034
Drop attacks 25.62 13.64 15 81215 1040 79662118
Dyslipidaemia 25.58 13.64 44 81186 11589 79651569
Oedema 25.58 13.64 52 81178 119528 79543630
Illusion 25.49 13.64 18 81212 1723 79661435
Somatic hallucination 25.48 13.64 7 81223 60 79663098
Circadian rhythm sleep disorder 25.42 13.64 13 81217 689 79662469
Cataract 25.29 13.64 16 81214 62104 79601054
Localised infection 25.25 13.64 4 81226 37571 79625587
COVID-19 24.90 13.64 80 81150 157594 79505564
Decreased appetite 24.82 13.64 226 81004 342192 79320966
Antipsychotic drug level above therapeutic 24.80 13.64 19 81211 2061 79661097
Diverticulitis 24.67 13.64 8 81222 45928 79617230
Gastrointestinal disorder 24.59 13.64 55 81175 122150 79541008
Neurotoxicity 24.57 13.64 81 81149 32437 79630721
Postoperative respiratory failure 24.38 13.64 9 81221 213 79662945
Nephrogenic diabetes insipidus 24.37 13.64 19 81211 2115 79661043
Abdominal pain 24.13 13.64 267 80963 389302 79273856
Psychomotor skills impaired 23.76 13.64 28 81202 5209 79657949
Cystitis 23.74 13.64 12 81218 52720 79610438
Haemorrhage 23.70 13.64 35 81195 91083 79572075
Heart rate decreased 23.67 13.64 22 81208 70294 79592864
Joint range of motion decreased 23.63 13.64 3 81227 33279 79629879
Feeling abnormal 23.61 13.64 83 81147 159116 79504042
Delusion of reference 23.61 13.64 8 81222 146 79663012
Hallucination, olfactory 23.56 13.64 11 81219 477 79662681
Pressure of speech 23.52 13.64 15 81215 1213 79661945
Gastrointestinal haemorrhage 23.29 13.64 75 81155 147644 79515514
Prescribed overdose 23.15 13.64 88 81142 37795 79625363
Hyperammonaemia 23.15 13.64 41 81189 11052 79652106
Osmotic demyelination syndrome 22.98 13.64 16 81214 1497 79661661
Gastric disorder 22.98 13.64 5 81225 37428 79625730
Red blood cell sedimentation rate increased 22.97 13.64 9 81221 45933 79617225
Basal cell carcinoma 22.93 13.64 5 81225 37370 79625788
Blood prolactin abnormal 22.89 13.64 23 81207 3578 79659580
Ventricular fibrillation 22.77 13.64 78 81152 31848 79631310
Coronary artery disease 22.62 13.64 20 81210 65454 79597704
Intestinal dilatation 22.43 13.64 20 81210 2680 79660478
Poor personal hygiene 22.43 13.64 11 81219 533 79662625
Disorganised speech 22.35 13.64 18 81212 2099 79661059
Body temperature increased 22.23 13.64 97 81133 44323 79618835
Compulsions 22.22 13.64 10 81220 398 79662760
Metabolic syndrome 22.18 13.64 20 81210 2720 79660438
Rhinorrhoea 22.04 13.64 27 81203 76047 79587111
Brain death 21.95 13.64 28 81202 5649 79657509
Upper respiratory tract infection 21.84 13.64 37 81193 91131 79572027
Bone pain 21.82 13.64 15 81215 55727 79607431
Blood pressure systolic increased 21.35 13.64 22 81208 66964 79596194
Screaming 21.20 13.64 23 81207 3910 79659248
Eosinophilia 21.18 13.64 97 81133 45248 79617910
Fungal infection 21.17 13.64 8 81222 41740 79621418
Eosinophilic myocarditis 21.13 13.64 14 81216 1208 79661950
Cerebral atrophy 21.08 13.64 33 81197 8042 79655116
Anaphylactic reaction 20.98 13.64 33 81197 83710 79579448
Drug diversion 20.84 13.64 14 81216 1236 79661922
Dry eye 20.61 13.64 6 81224 36925 79626233
Colitis ulcerative 20.61 13.64 5 81225 34737 79628421
Inappropriate affect 20.47 13.64 15 81215 1521 79661637
Cytomegalovirus infection 20.28 13.64 9 81221 42635 79620523
Inappropriate schedule of product administration 20.27 13.64 69 81161 133559 79529599
Thrombosis 20.26 13.64 34 81196 84066 79579092
Electrocardiogram PR prolongation 20.07 13.64 15 81215 1568 79661590
Nephrolithiasis 20.00 13.64 15 81215 53276 79609882
Physical assault 19.83 13.64 15 81215 1596 79661562
Anaphylactic shock 19.81 13.64 6 81224 35990 79627168
Visual impairment 19.75 13.64 40 81190 92091 79571067
Feeling hot 19.74 13.64 19 81211 59715 79603443
Red blood cells urine 19.62 13.64 11 81219 702 79662456
Therapy interrupted 19.62 13.64 4 81226 31337 79631821
Migraine 19.61 13.64 37 81193 87456 79575702
Urinary tract infection 19.53 13.64 182 81048 274330 79388828
Lactate pyruvate ratio increased 19.52 13.64 6 81224 79 79663079
Amenorrhoea 19.47 13.64 31 81199 7661 79655497
Pneumonia 19.45 13.64 518 80712 659728 79003430
Obesity 19.37 13.64 79 81151 35046 79628112
Self-medication 19.35 13.64 25 81205 5107 79658051
Bone marrow eosinophilic leukocyte count increased 19.35 13.64 5 81225 33 79663125
Clostridium difficile infection 18.79 13.64 10 81220 42675 79620483
Gaze palsy 18.75 13.64 19 81211 2986 79660172
Pneumocystis jirovecii pneumonia 18.67 13.64 5 81225 32503 79630655
Poverty of speech 18.66 13.64 10 81220 584 79662574
Full blood count abnormal 18.54 13.64 9 81221 40465 79622693
Ear infection 18.49 13.64 6 81224 34426 79628732
Femoral neck fracture 18.43 13.64 35 81195 9949 79653209
Wolff-Parkinson-White syndrome 18.35 13.64 8 81222 295 79662863
Loss of consciousness 18.31 13.64 256 80974 167687 79495471
Allergic hepatitis 18.29 13.64 5 81225 42 79663116
Wrong patient received product 18.21 13.64 23 81207 4595 79658563
Influenza like illness 18.21 13.64 28 81202 71679 79591479
Electroconvulsive therapy 18.16 13.64 6 81224 101 79663057
Visual acuity reduced 17.96 13.64 4 81226 29465 79633693
Device issue 17.96 13.64 3 81227 27105 79636053
Exhibitionism 17.89 13.64 5 81225 46 79663112
Drug-disease interaction 17.70 13.64 12 81218 1075 79662083
Logorrhoea 17.63 13.64 22 81208 4343 79658815
Productive cough 17.57 13.64 40 81190 88291 79574867
Polydipsia psychogenic 17.50 13.64 7 81223 207 79662951
False positive investigation result 17.46 13.64 12 81218 1100 79662058
Osteonecrosis 17.45 13.64 5 81225 31090 79632068
Echopraxia 17.42 13.64 5 81225 51 79663107
Gender dysphoria 17.42 13.64 5 81225 51 79663107
Hyperthermia malignant 17.40 13.64 18 81212 2899 79660259
Pituitary tumour benign 17.39 13.64 17 81213 2559 79660599
Tinnitus 17.26 13.64 12 81218 44321 79618837
Dyspepsia 17.25 13.64 55 81175 108632 79554526
Grimacing 17.24 13.64 10 81220 681 79662477
Tooth disorder 17.17 13.64 3 81227 26230 79636928
Haemoptysis 17.16 13.64 19 81211 55980 79607178
Transient ischaemic attack 17.14 13.64 17 81213 52678 79610480
Surgery 17.08 13.64 6 81224 32760 79630398
Blood phosphorus decreased 17.06 13.64 27 81203 6641 79656517
Pulmonary arterial hypertension 16.99 13.64 4 81226 28362 79634796
Swelling face 16.96 13.64 29 81201 71183 79591975
Dysgeusia 16.87 13.64 20 81210 57157 79606001
Incoherent 16.79 13.64 29 81201 7663 79655495
Blood citric acid increased 16.77 13.64 5 81225 59 79663099
Blood pressure diastolic decreased 16.70 13.64 5 81225 30211 79632947
Abdominal distension 16.67 13.64 64 81166 119586 79543572
Injection site haemorrhage 16.55 13.64 4 81226 27866 79635292
Accidental overdose 16.54 13.64 82 81148 39499 79623659
Paraphilia 16.54 13.64 5 81225 62 79663096
Poisoning 16.52 13.64 60 81170 25212 79637946
Intestinal obstruction 16.50 13.64 87 81143 42933 79620225
Ulcer 16.49 13.64 5 81225 29967 79633191
Tachyphrenia 16.48 13.64 15 81215 2065 79661093
Angina pectoris 16.47 13.64 17 81213 51715 79611443
Eosinophil count abnormal 16.47 13.64 10 81220 741 79662417
Posture abnormal 16.44 13.64 20 81210 3846 79659312
Haemoglobin decreased 16.34 13.64 146 81084 221973 79441185
Snoring 16.30 13.64 24 81206 5542 79657616
Perseveration 16.28 13.64 8 81222 389 79662769
Tongue biting 16.23 13.64 15 81215 2106 79661052
Oral herpes 16.19 13.64 4 81226 27450 79635708
Skin discolouration 16.12 13.64 11 81219 41023 79622135
Limb injury 16.11 13.64 5 81225 29523 79633635
Antisocial personality disorder 16.05 13.64 5 81225 69 79663089
Duodenal stenosis 16.04 13.64 10 81220 777 79662381
Unevaluable event 15.82 13.64 20 81210 55565 79607593
Judgement impaired 15.77 13.64 12 81218 1288 79661870
Vascular stenosis 15.73 13.64 9 81221 597 79662561
Cerebrovascular stenosis 15.65 13.64 6 81224 158 79663000
Haemodynamic instability 15.63 13.64 46 81184 17336 79645822
Hypotonia 15.55 13.64 38 81192 12832 79650326
Verbal abuse 15.55 13.64 7 81223 279 79662879
Loss of personal independence in daily activities 15.53 13.64 53 81177 102527 79560631
Mental disorder due to a general medical condition 15.52 13.64 7 81223 280 79662878
Injury 15.49 13.64 35 81195 77461 79585697
Disease progression 15.47 13.64 117 81113 184245 79478913
Maternal exposure during pregnancy 15.42 13.64 79 81151 136459 79526699
Labelled drug-food interaction medication error 15.38 13.64 6 81224 166 79662992
Eye swelling 15.33 13.64 4 81226 26464 79636694
Polyneuropathy 15.29 13.64 3 81227 24148 79639010
Scrotal haematoma 15.25 13.64 5 81225 82 79663076
Product use in unapproved indication 15.25 13.64 348 80882 250011 79413147
Drug screen false positive 15.17 13.64 11 81219 1098 79662060
Neck pain 15.12 13.64 34 81196 75383 79587775
Vascular dementia 15.03 13.64 10 81220 869 79662289
Device dislocation 14.90 13.64 4 81226 25966 79637192
Impaired self-care 14.89 13.64 16 81214 2691 79660467
Presyncope 14.84 13.64 12 81218 41042 79622116
Autism spectrum disorder 14.79 13.64 11 81219 1141 79662017
Hyperkinesia 14.78 13.64 16 81214 2713 79660445
Drug-induced liver injury 14.78 13.64 28 81202 66089 79597069
Electrocardiogram abnormal 14.77 13.64 44 81186 16693 79646465
Megacolon 14.73 13.64 18 81212 3477 79659681
Eczema 14.67 13.64 12 81218 40806 79622352
Haematuria 14.66 13.64 30 81200 68806 79594352
Epileptic encephalopathy 14.60 13.64 8 81222 488 79662670
Sedation complication 14.60 13.64 42 81188 15627 79647531
Borderline personality disorder 14.54 13.64 10 81220 917 79662241
Liver injury 14.48 13.64 22 81208 56592 79606566
Ascites 14.40 13.64 35 81195 75527 79587631
Hot flush 14.35 13.64 21 81209 54856 79608302
Procedural pain 14.34 13.64 3 81227 23081 79640077
Pneumonitis 14.30 13.64 25 81205 60835 79602323
Chills 14.25 13.64 100 81130 160134 79503024
Abscess 14.22 13.64 3 81227 22948 79640210
Muscle spasms 14.13 13.64 112 81118 174618 79488540
Cheyne-Stokes respiration 14.12 13.64 8 81222 521 79662637
Porphyria acute 14.02 13.64 12 81218 1523 79661635
Blood glucose 14.01 13.64 4 81226 40 79663118
Osteonecrosis of jaw 14.00 13.64 14 81216 43212 79619946
Diabetic coma 13.99 13.64 11 81219 1240 79661918
Gastroenteritis viral 13.92 13.64 4 81226 24827 79638331
Skin ulcer 13.89 13.64 21 81209 54129 79609029
Tongue spasm 13.84 13.64 5 81225 111 79663047
Colectomy total 13.81 13.64 7 81223 364 79662794
Product dispensing error 13.79 13.64 37 81193 13226 79649932
Exposure to extreme temperature 13.78 13.64 3 81227 8 79663150
Dyspnoea paroxysmal nocturnal 13.74 13.64 14 81216 2214 79660944
Breathing-related sleep disorder 13.72 13.64 6 81224 223 79662935

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05AD01 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Butyrophenone derivatives
MeSH PA D018726 Anti-Dyskinesia Agents
MeSH PA D000932 Antiemetics
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D015259 Dopamine Agents
MeSH PA D018492 Dopamine Antagonists
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents
CHEBI has role CHEBI:48279 serotonin antagonists
CHEBI has role CHEBI:48561 dopaminergic antagonists
CHEBI has role CHEBI:50919 antiemetico
CHEBI has role CHEBI:65190 typical antipsychotic drugs
CHEBI has role CHEBI:66956 antidyskinetic agent
FDA EPC N0000180182 Typical Antipsychotic

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Gilles de la Tourette's syndrome indication 5158005 DOID:11119
Schizophrenia indication 58214004 DOID:5419
Psychotic disorder indication 69322001
Chronic schizophrenia indication 83746006
Delirium off-label use 2776000
Nausea and vomiting off-label use 16932000
Pain off-label use 22253000
Anxiety disorder off-label use 197480006 DOID:2030
Headache disorder off-label use 230461009
Gastroparesis off-label use 235675006
Chemotherapy-induced nausea and vomiting off-label use 236084000
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Senile dementia contraindication 15662003
Agranulocytosis contraindication 17182001 DOID:12987
Thyrotoxic crisis contraindication 29028009 DOID:12837
Torsades de pointes contraindication 31722008
Parkinsonism contraindication 32798002
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Low blood pressure contraindication 45007003
Extrapyramidal disease contraindication 76349003
Leukopenia contraindication 84828003 DOID:615
Tardive dyskinesia contraindication 102449007
Prolonged QT interval contraindication 111975006
Seizure disorder contraindication 128613002
Hypomagnesemia contraindication 190855004
Angina pectoris contraindication 194828000
Disease of liver contraindication 235856003 DOID:409
Retention of urine contraindication 267064002
Neutropenic disorder contraindication 303011007 DOID:1227
Coma contraindication 371632003
Breastfeeding (mother) contraindication 413712001
Central nervous system depression contraindication 418072004
Acquired torsion dystonia contraindication 433493000
Congenital long QT syndrome contraindication 442917000
Carcinoma of female breast contraindication 447782002
Smokes tobacco daily contraindication 449868002
Drug Induced CNS Depression contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.36 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
D(2) dopamine receptor GPCR INVERSE AGONIST Ki 9.15 WOMBAT-PK CHEMBL
5-hydroxytryptamine receptor 5A GPCR Ki 5.65 PDSP
5-hydroxytryptamine receptor 1F GPCR Ki 5.30 PDSP
5-hydroxytryptamine receptor 1E GPCR Ki 5.30 PDSP
Beta-2 adrenergic receptor GPCR Ki 5.30 PDSP
Mu-type opioid receptor GPCR Ki 6.00 DRUG MATRIX
D(1A) dopamine receptor GPCR Ki 7.82 WOMBAT-PK
Alpha-2A adrenergic receptor GPCR Ki 5.95 PDSP
Sigma non-opioid intracellular receptor 1 Membrane receptor EC50 8.92 WOMBAT-PK
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 7.50 WOMBAT-PK
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase Enzyme Ki 6.72 WOMBAT-PK
Multidrug resistance protein 1 Transporter Ki 6.70 WOMBAT-PK
Sodium-dependent serotonin transporter Transporter Ki 5.74 CHEMBL
Sodium-dependent noradrenaline transporter Transporter Ki 5.74 DRUG MATRIX
5-hydroxytryptamine receptor 1A GPCR Ki 5.55 CHEMBL
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 7 WOMBAT-PK
5-hydroxytryptamine receptor 2B GPCR Ki 6.10 WOMBAT-PK
5-hydroxytryptamine receptor 2C GPCR Ki 5.33 CHEMBL
5-hydroxytryptamine receptor 6 GPCR Ki 5.22 CHEMBL
5-hydroxytryptamine receptor 7 GPCR Ki 6.45 WOMBAT-PK
Alpha-1A adrenergic receptor GPCR Ki 7.90 WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 6.32 PDSP
D(3) dopamine receptor GPCR INVERSE AGONIST Ki 8.52 WOMBAT-PK
D(1B) dopamine receptor GPCR Ki 7.52 WOMBAT-PK
Histamine H1 receptor GPCR Ki 6.36 CHEMBL
Histamine H2 receptor GPCR Ki 6.00 PDSP
Muscarinic acetylcholine receptor M1 GPCR Ki 5.80 CHEMBL
Muscarinic acetylcholine receptor M3 GPCR Ki 5 PDSP
Muscarinic acetylcholine receptor M5 GPCR Ki 6.18 PDSP
5-hydroxytryptamine receptor 1B GPCR Ki 6.57 PDSP
5-hydroxytryptamine receptor 1D GPCR ANTAGONIST Ki 6.60 IUPHAR
Alpha-2C adrenergic receptor GPCR Ki 6.26 PDSP
Alpha-1D adrenergic receptor GPCR Ki 7.55 DRUG MATRIX
Alpha-1B adrenergic receptor GPCR Ki 8.10 PDSP
Potassium channel subfamily K member 2 Ion channel IC50 5.26 CHEMBL
Potassium voltage-gated channel subfamily H member 1 Ion channel BLOCKER IC50 6.20 IUPHAR
Sodium channel alpha subunits; brain (Types I, II, III) Ion channel IC50 5.92 CHEMBL
Histone H1.0 Nuclear other Ki 6.11 CHEMBL
Transmembrane protein 97 Enzyme Ki 7.80 CHEMBL
Calmodulin Cytosolic other IC50 6.30 WOMBAT-PK
D(4) dopamine receptor GPCR INVERSE AGONIST Kd 9.42 SCIENTIFIC LITERATURE
Alpha-1B adrenergic receptor GPCR Ki 8.31 DRUG MATRIX
Membrane-associated progesterone receptor component 1 Membrane receptor Ki 7.44 DRUG MATRIX
Pol polyprotein Enzyme Ki 7 CHEMBL
Alpha-1A adrenergic receptor GPCR Kd 7.76 CHEMBL
Histamine H1 receptor GPCR Ki 6.40 CHEMBL
Muscarinic acetylcholine receptor M2 GPCR Ki 6.62 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Ki 5.74 CHEMBL
D(2) dopamine receptor GPCR Ki 9.70 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 6.40 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 7.35 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 9.05 CHEMBL
5-hydroxytryptamine receptor 7 GPCR Ki 6.58 CHEMBL
5-hydroxytryptamine receptor 7 GPCR ANTAGONIST Ki 6.30 IUPHAR
D(1A) dopamine receptor GPCR Ki 7.70 CHEMBL
D(2) dopamine receptor GPCR Ki 9.52 CHEMBL
Alpha-1A adrenergic receptor GPCR IC50 7.70 CHEMBL
Histamine H1 receptor GPCR Ki 6.42 CHEMBL
D(3) dopamine receptor GPCR Ki 8.52 CHEMBL
Protease Enzyme Ki 7 CHEMBL
D(2) dopamine receptor GPCR Ki 8.32 CHEMBL
5-hydroxytryptamine receptor 2A GPCR IC50 7.52 CHEMBL
C-8 sterol isomerase Enzyme Ki 9.30 CHEMBL
D(1A) dopamine receptor GPCR Ki 7.03 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane other Ki 9.08 CHEMBL
Transporter Transporter Ki 5.26 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 7.52 CHEMBL
D(3) dopamine receptor GPCR Ki 8.52 CHEMBL
Vesicular acetylcholine transporter Transporter Ki 6.41 CHEMBL
AP-2 complex subunit sigma Unclassified Ki 7.62 CHEMBL
Muscarinic acetylcholine receptor GPCR Ki 5.13 CHEMBL
Opioid receptor GPCR Ki 5.92 CHEMBL
Serotonin 1 (5-HT1) receptor GPCR IC50 4.70 CHEMBL
Adrenergic receptor alpha-2 GPCR Ki 5.57 CHEMBL
Dopamine receptor GPCR IC50 8.74 CHEMBL
Dopamine receptor GPCR Ki 8.70 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR Ki 8.38 CHEMBL
Adenylate cyclase Enzyme IC50 5.64 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR Ki 7.58 CHEMBL
G protein-activated inward rectifier potassium channel 2 Ion channel GATING INHIBITOR EC50 4.10 IUPHAR
Sigma intracellular receptor 2 Unclassified Ki 7.36 CHEMBL
Zinc finger protein 664 Unclassified Ki 8.18 CHEMBL

External reference:

IDSource
4018123 VUID
N0000146461 NUI
D00136 KEGG_DRUG
53515-91-6 SECONDARY_CAS_RN
4018123 VANDF
4018125 VANDF
C0018546 UMLSCUI
CHEBI:5613 CHEBI
GMJ PDB_CHEM_ID
CHEMBL54 ChEMBL_ID
DB00502 DRUGBANK_ID
CHEMBL2096643 ChEMBL_ID
CHEMBL4297147 ChEMBL_ID
D006220 MESH_DESCRIPTOR_UI
3559 PUBCHEM_CID
86 IUPHAR_LIGAND_ID
918 INN_ID
J6292F8L3D UNII
217483 RXNORM
2958 MMSL
4816 MMSL
4818 MMSL
583 MMSL
d00027 MMSL
001518 NDDF
001521 NDDF
10756001 SNOMEDCT_US
386837002 SNOMEDCT_US
412197008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0121-0581 SOLUTION 2 mg ORAL ANDA 17 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0121-0581 SOLUTION 2 mg ORAL ANDA 17 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0121-0581 SOLUTION 2 mg ORAL ANDA 17 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0143-9319 INJECTION 5 mg INTRAMUSCULAR ANDA 16 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0143-9319 INJECTION 5 mg INTRAMUSCULAR ANDA 16 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0143-9501 INJECTION 5 mg INTRAMUSCULAR ANDA 16 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0143-9502 INJECTION 5 mg INTRAMUSCULAR ANDA 16 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0214 TABLET 2 mg ORAL ANDA 17 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0214 TABLET 2 mg ORAL ANDA 17 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0214 TABLET 2 mg ORAL ANDA 17 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0257 TABLET 1 mg ORAL ANDA 17 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0257 TABLET 1 mg ORAL ANDA 17 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0257 TABLET 1 mg ORAL ANDA 17 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0327 TABLET 5 mg ORAL ANDA 17 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0327 TABLET 5 mg ORAL ANDA 17 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0327 TABLET 5 mg ORAL ANDA 17 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0334 TABLET 10 mg ORAL ANDA 17 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0334 TABLET 10 mg ORAL ANDA 17 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0334 TABLET 10 mg ORAL ANDA 17 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0335 TABLET 20 mg ORAL ANDA 17 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0335 TABLET 20 mg ORAL ANDA 17 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0335 TABLET 20 mg ORAL ANDA 17 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0351 TABLET 0.50 mg ORAL ANDA 17 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0351 TABLET 0.50 mg ORAL ANDA 17 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0351 TABLET 0.50 mg ORAL ANDA 17 sections
Haloperidol Lactate HUMAN PRESCRIPTION DRUG LABEL 1 0404-9871 INJECTION, SOLUTION 5 mg INTRAMUSCULAR ANDA 12 sections
Haloperidol Lactate HUMAN PRESCRIPTION DRUG LABEL 1 0404-9871 INJECTION, SOLUTION 5 mg INTRAMUSCULAR ANDA 12 sections
Haloperidol Lactate HUMAN PRESCRIPTION DRUG LABEL 1 0404-9871 INJECTION, SOLUTION 5 mg INTRAMUSCULAR ANDA 12 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0615-8355 TABLET 5 mg ORAL ANDA 15 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0832-1510 TABLET 0.50 mg ORAL ANDA 15 sections