guanidine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1344 113-00-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • guanidine
  • aminoformamidine
  • iminourea
  • guanidin
  • carbamamidine
  • guanidine hydrochloride
  • guanidine HCl
A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
  • Molecular weight: 59.07
  • Formula: CH5N3
  • CLOGP: -2.39
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 3
  • TPSA: 75.89
  • ALOGS: -0.71
  • ROTB: 0

Drug dosage:

None

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 592.51 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Oct. 2, 1939 FDA MERCK SHARP DOHME

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
FDA EPC N0000175772 Acetylcholine Releasing Agent
FDA PE N0000009079 Increased Acetylcholine Activity

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Eaton-Lambert syndrome indication 56989000 DOID:0050214
Leukopenia contraindication 84828003 DOID:615
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Breastfeeding (mother) contraindication 413712001

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.39 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Voltage-gated potassium channel Ion channel BLOCKER CHEMBL CHEMBL

External reference:

IDSource
4019772 VUID
N0000147863 NUI
C0120446 UMLSCUI
3YQC9ZY4YB UNII
50-01-1 SECONDARY_CAS_RN
409368007 SNOMEDCT_US
4019772 VANDF
50675 RXNORM
109108004 SNOMEDCT_US
d01422 MMSL
004685 NDDF
3520 PUBCHEM_CID
CHEBI:42820 CHEBI
CHEMBL821 ChEMBL_ID
DB00536 DRUGBANK_ID
CHEMBL1200728 ChEMBL_ID
GAI PDB_CHEM_ID
D019791 MESH_DESCRIPTOR_UI
4783 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Guanidine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0085-0492 TABLET 125 mg ORAL NDA 12 sections