guanadrel ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antihypertensives, guanidine derivatives 1339 40580-59-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hylorel
  • guanadrel
  • guanadrel sulfate
  • Molecular weight: 213.28
  • Formula: C10H19N3O2
  • CLOGP: 0.80
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 80.36
  • ALOGS: -2.09
  • ROTB: 2

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 18.48 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 85 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Dec. 29, 1982 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
CHEBI has role CHEBI:35674 antihypertensive drugs
CHEBI has role CHEBI:37887 adrenergic blockers

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.82 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent noradrenaline transporter Transporter SUBSTRATE DRUGBANK CHEMBL
Alpha-1A adrenergic receptor GPCR WOMBAT-PK

External reference:

IDSource
4019769 VUID
N0000179147 NUI
D00607 KEGG_DRUG
22195-34-2 SECONDARY_CAS_RN
4018079 VANDF
4019769 VANDF
C0061938 UMLSCUI
CHEBI:5555 CHEBI
CHEMBL1037 ChEMBL_ID
DB00226 DRUGBANK_ID
CHEMBL3184143 ChEMBL_ID
38521 PUBCHEM_CID
2590 INN_ID
C004945 MESH_SUPPLEMENTAL_RECORD_UI
7193 IUPHAR_LIGAND_ID
765C9332T4 UNII
217653 RXNORM
1821 MMSL
4807 MMSL
d00725 MMSL
000641 NDDF
004494 NDDF
14013006 SNOMEDCT_US
372820001 SNOMEDCT_US
69204002 SNOMEDCT_US

Pharmaceutical products:

None