guaifenesin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1336 93-14-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • guaifenesin
  • glycerin guaiacolate
  • glycerol guaiacolate
  • guaifenesine
  • guaiphenesin
  • guaiphenesine
  • myocain
  • myocaine
  • myoscain
An expectorant that also has some muscle relaxing action. It is used in many cough preparations.
  • Molecular weight: 198.22
  • Formula: C10H14O4
  • CLOGP: 0.10
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 58.92
  • ALOGS: -1.12
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.90 g O
0.90 g P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
July 12, 2002 FDA RECKITT BENCKISER

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Irritable bowel syndrome 503.90 9.87 990 241837 67468 55981772
Folliculitis 494.87 9.87 867 241960 54112 55995128
Sinusitis 493.97 9.87 1920 240907 195661 55853579
Muscle injury 493.58 9.87 844 241983 51656 55997584
Lower respiratory tract infection 462.94 9.87 1312 241515 113482 55935758
Peripheral swelling 409.38 9.87 2048 240779 232678 55816562
Drug interaction 405.48 9.87 199 242628 209556 55839684
Nasopharyngitis 383.91 9.87 1926 240901 219033 55830207
Ill-defined disorder 336.51 9.87 843 241984 67700 55981540
Sleep disorder due to general medical condition, insomnia type 327.62 9.87 634 242193 42704 56006536
Impaired healing 325.36 9.87 967 241860 85874 55963366
Pruritus 301.33 9.87 2365 240462 314258 55734982
Gastrointestinal disorder 297.50 9.87 1115 241712 111587 55937653
Toxicity to various agents 287.43 9.87 327 242500 224237 55825003
Body temperature increased 279.94 9.87 518 242309 33724 56015516
Ear pain 277.68 9.87 487 242340 30403 56018837
Stomatitis 266.48 9.87 1130 241697 119680 55929560
Blister 265.06 9.87 1050 241777 107837 55941403
Weight increased 250.16 9.87 1772 241055 227931 55821309
Muscle spasticity 245.57 9.87 363 242464 19597 56029643
Completed suicide 225.53 9.87 150 242677 133683 55915557
Night sweats 202.32 9.87 507 242320 40706 56008534
Acute kidney injury 172.22 9.87 502 242325 240261 55808979
Respiratory disorder 170.10 9.87 421 242406 33536 56015704
Back pain 167.36 9.87 1660 241167 235510 55813730
Infusion related reaction 164.10 9.87 1496 241331 207435 55841805
Fatigue 158.57 9.87 4483 238344 784069 55265171
Joint swelling 155.76 9.87 1922 240905 287878 55761362
Pain 151.11 9.87 3833 238994 659351 55389889
Headache 145.41 9.87 3291 239536 555753 55493487
Insomnia 140.22 9.87 1353 241474 190507 55858733
Contusion 139.12 9.87 990 241837 127440 55921800
Urticaria 139.02 9.87 1084 241743 143592 55905648
Blood pressure fluctuation 131.22 9.87 428 242399 39932 56009308
Infection 130.51 9.87 1379 241448 198827 55850413
Therapeutic product effect decreased 114.57 9.87 1176 241651 168276 55880964
Blood pressure diastolic abnormal 112.27 9.87 189 242638 11409 56037831
Blood pressure increased 105.12 9.87 1022 241805 144154 55905086
General physical health deterioration 104.45 9.87 379 242448 169631 55879609
Arthralgia 100.30 9.87 2852 239975 498817 55550423
Hypersensitivity 99.15 9.87 1605 241222 254803 55794437
Blood pressure systolic increased 96.22 9.87 390 242437 40446 56008794
Cardiac failure 94.96 9.87 129 242698 81964 55967276
Neutropenia 94.27 9.87 357 242470 157810 55891430
Thrombocytopenia 92.30 9.87 291 242536 135933 55913307
Electrocardiogram QT prolonged 90.80 9.87 62 242765 54526 55994714
Hyponatraemia 90.08 9.87 191 242636 101948 55947292
Temperature regulation disorder 85.58 9.87 101 242726 4367 56044873
Heart rate increased 85.56 9.87 634 242193 82639 55966601
Anaemia 84.64 9.87 742 242085 266769 55782471
Hepatocellular injury 82.52 9.87 9 242818 26505 56022735
Bursitis 82.12 9.87 284 242543 27298 56021942
Device expulsion 81.69 9.87 16 242811 30433 56018807
Lactic acidosis 80.51 9.87 26 242801 35320 56013920
Blood pressure systolic abnormal 80.00 9.87 148 242679 9629 56039611
Maternal exposure during pregnancy 79.58 9.87 485 242342 189068 55860172
Confusional state 77.09 9.87 1294 241533 206861 55842379
Sopor 77.06 9.87 3 242824 20919 56028321
Rhabdomyolysis 76.30 9.87 40 242787 40618 56008622
Exposure during pregnancy 74.75 9.87 318 242509 136024 55913216
Dyspnoea 74.52 9.87 3194 239633 589383 55459857
Pancytopenia 72.43 9.87 173 242654 88542 55960698
Asthenia 71.50 9.87 1961 240866 341012 55708228
Epilepsy 70.40 9.87 12 242815 25219 56024021
Seizure 69.71 9.87 290 242537 124829 55924411
Cholestasis 68.41 9.87 16 242811 26897 56022343
Coma 67.72 9.87 95 242732 59560 55989680
Leukopenia 67.39 9.87 127 242700 70813 55978427
Drug resistance 66.47 9.87 6 242821 20536 56028704
Drug reaction with eosinophilia and systemic symptoms 66.07 9.87 24 242803 30280 56018960
Hypotension 65.32 9.87 728 242099 249780 55799460
Food allergy 65.31 9.87 128 242699 8696 56040544
Cardiac arrest 65.29 9.87 175 242652 86139 55963101
Hyperkalaemia 65.03 9.87 74 242753 50791 55998449
Agranulocytosis 64.96 9.87 10 242817 22649 56026591
Helicobacter infection 63.81 9.87 537 242290 72731 55976509
Pleural fibrosis 62.65 9.87 76 242751 3383 56045857
Presbyacusis 62.56 9.87 69 242758 2769 56046471
Bone marrow failure 62.35 9.87 22 242805 28264 56020976
Osteonecrosis of jaw 62.33 9.87 33 242794 33325 56015915
Sleep disorder 62.19 9.87 502 242325 67161 55982079
Pleural thickening 61.41 9.87 67 242760 2656 56046584
Drug abuse 60.80 9.87 125 242702 67485 55981755
Toxic epidermal necrolysis 60.37 9.87 11 242816 22031 56027209
Condition aggravated 59.00 9.87 1090 241737 343808 55705432
Multiple organ dysfunction syndrome 57.96 9.87 86 242741 52684 55996556
Swelling 57.51 9.87 1397 241430 238374 55810866
Hypoglycaemia 57.47 9.87 95 242732 55720 55993520
Oxygen saturation decreased 57.36 9.87 557 242270 78510 55970730
Depressed level of consciousness 57.23 9.87 97 242730 56336 55992904
Blood magnesium increased 57.01 9.87 67 242760 2884 56046356
Pyrexia 56.56 9.87 2275 240552 416498 55632742
Oropharyngeal pain 56.32 9.87 581 242246 83207 55966033
C-reactive protein increased 56.19 9.87 164 242663 78520 55970720
Hepatic function abnormal 55.17 9.87 41 242786 34517 56014723
Angioedema 53.32 9.87 60 242767 41393 56007847
Abdominal pain upper 51.90 9.87 1068 241759 177245 55871995
Cardio-respiratory arrest 50.84 9.87 101 242726 55220 55994020
Mucosal inflammation 50.79 9.87 66 242761 42744 56006496
Cytomegalovirus infection 49.99 9.87 11 242816 19285 56029955
Circulatory collapse 49.74 9.87 14 242813 20789 56028451
Orthostatic hypotension 49.71 9.87 42 242785 33157 56016083
Duodenal ulcer perforation 49.35 9.87 481 242346 67861 55981379
Rash 49.17 9.87 2598 240229 490449 55558791
Chest discomfort 47.60 9.87 643 242184 98214 55951026
Serotonin syndrome 46.91 9.87 28 242799 26462 56022778
Drug-induced liver injury 46.42 9.87 48 242779 34414 56014826
Metabolic acidosis 46.34 9.87 64 242763 40390 56008850
Myelosuppression 45.12 9.87 10 242817 17445 56031795
Hypocalcaemia 44.79 9.87 35 242792 28725 56020515
Altered state of consciousness 44.16 9.87 22 242805 22999 56026241
Rheumatoid factor positive 43.67 9.87 152 242675 68908 55980332
Urine abnormality 43.45 9.87 92 242735 6607 56042633
Intentional self-injury 43.44 9.87 27 242800 24965 56024275
Deafness neurosensory 43.41 9.87 75 242752 4623 56044617
Malignant neoplasm progression 43.22 9.87 167 242660 73420 55975820
Epigastric discomfort 43.09 9.87 88 242739 6160 56043080
Septic shock 42.57 9.87 128 242699 60707 55988533
Flushing 41.96 9.87 475 242352 69625 55979615
Cough 40.96 9.87 1437 241390 258524 55790716
Injection site pain 40.54 9.87 317 242510 116801 55932439
Gamma-glutamyltransferase increased 39.75 9.87 45 242782 30960 56018280
Renal failure 39.70 9.87 296 242531 110204 55939036
Blood pressure diastolic increased 39.59 9.87 103 242724 8458 56040782
Foetal exposure during pregnancy 39.25 9.87 53 242774 33770 56015470
Hypokalaemia 38.88 9.87 243 242584 94194 55955046
Urine leukocyte esterase positive 38.63 9.87 57 242770 3071 56046169
Sinus disorder 38.19 9.87 184 242643 20550 56028690
Rash maculo-papular 38.11 9.87 41 242786 28866 56020374
Sedation 38.08 9.87 57 242770 34797 56014443
Osteonecrosis 37.76 9.87 27 242800 23188 56026052
Coeliac disease 37.60 9.87 114 242713 10225 56039015
Abortion spontaneous 37.58 9.87 83 242744 43670 56005570
Influenza 37.35 9.87 598 242229 94663 55954577
Skin necrosis 36.49 9.87 5 242822 12356 56036884
Generalised tonic-clonic seizure 36.45 9.87 39 242788 27527 56021713
Bradycardia 36.02 9.87 159 242668 67345 55981895
Syncope 35.54 9.87 297 242530 107902 55941338
Dyskinesia 35.44 9.87 44 242783 29064 56020176
Neovascularisation 35.12 9.87 32 242795 1017 56048223
Myoclonus 34.95 9.87 11 242816 15192 56034048
Injection site erythema 34.68 9.87 194 242633 77254 55971986
Bone cyst 34.44 9.87 44 242783 2066 56047174
Lip dry 34.12 9.87 106 242721 9634 56039606
Drug ineffective 34.05 9.87 3460 239367 915529 55133711
Pancreatitis acute 33.83 9.87 35 242792 25089 56024151
Peptic ulcer haemorrhage 33.49 9.87 31 242796 1006 56048234
Osteopenia 33.42 9.87 161 242666 17980 56031260
Immunodeficiency 33.16 9.87 148 242679 16009 56033231
Melaena 33.16 9.87 44 242783 28246 56020994
Osteoarthritis 32.97 9.87 508 242319 79788 55969452
Rhinorrhoea 32.57 9.87 383 242444 56654 55992586
Throat irritation 32.51 9.87 247 242580 32436 56016804
Poisoning deliberate 31.95 9.87 3 242824 9950 56039290
Overdose 31.89 9.87 297 242530 105533 55943707
Accidental exposure to product 31.34 9.87 36 242791 24611 56024629
Torsade de pointes 30.44 9.87 8 242819 12432 56036808
Blood pressure diastolic decreased 30.36 9.87 164 242663 19159 56030081
Interstitial lung disease 30.09 9.87 135 242692 56928 55992312
Nasal congestion 29.78 9.87 373 242454 55997 55993243
Status epilepticus 29.76 9.87 14 242813 15127 56034113
Red blood cells urine positive 29.72 9.87 49 242778 2907 56046333
Lymphopenia 29.32 9.87 18 242809 16756 56032484
Chills 28.99 9.87 612 242215 101992 55947248
Renal impairment 28.61 9.87 217 242610 80496 55968744
Treatment failure 28.29 9.87 541 242286 169851 55879389
Alanine aminotransferase increased 28.16 9.87 263 242564 93399 55955841
Illness 27.97 9.87 249 242578 34262 56014978
Pemphigus 27.71 9.87 494 242333 156718 55892522
Sedation complication 27.64 9.87 8 242819 11664 56037576
Wrong technique in product usage process 27.54 9.87 143 242684 58025 55991215
Agitation 27.53 9.87 136 242691 55900 55993340
Labelled drug-drug interaction medication error 27.33 9.87 8 242819 11578 56037662
Lower limb fracture 27.17 9.87 149 242678 17506 56031734
Drug tolerance decreased 26.98 9.87 12 242815 13399 56035841
Hypothermia 26.97 9.87 10 242817 12460 56036780
Suicide attempt 26.92 9.87 143 242684 57693 55991547
Suicidal ideation 26.75 9.87 143 242684 57599 55991641
Premature baby 26.72 9.87 26 242801 19179 56030061
Poisoning 26.52 9.87 11 242816 12802 56036438
Disorientation 26.36 9.87 76 242751 36537 56012703
Creatinine renal clearance decreased 26.33 9.87 15 242812 14544 56034696
Product prescribing error 26.23 9.87 37 242790 23149 56026091
Aspartate aminotransferase increased 26.11 9.87 229 242598 82373 55966867
Shock haemorrhagic 25.86 9.87 4 242823 9029 56040211
Blood creatine phosphokinase increased 25.70 9.87 51 242776 27901 56021339
Constipation 25.55 9.87 1090 241737 200853 55848387
Upper respiratory tract infection 25.54 9.87 441 242386 70847 55978393
Drug eruption 25.46 9.87 45 242782 25718 56023522
Febrile neutropenia 25.42 9.87 312 242515 105233 55944007
Hepatotoxicity 25.22 9.87 61 242766 31092 56018148
Systemic lupus erythematosus 25.14 9.87 588 242239 179490 55869750
Transplant rejection 25.06 9.87 6 242821 9928 56039312
Eosinophilia 24.81 9.87 30 242797 20047 56029193
Heart rate decreased 24.67 9.87 275 242552 40152 56009088
Rheumatoid nodule 24.53 9.87 17 242810 14840 56034400
Fluid retention 24.50 9.87 348 242479 53730 55995510
Red cell distribution width increased 24.26 9.87 92 242735 9248 56039992
Lupus vasculitis 24.23 9.87 19 242808 489 56048751
Ejection fraction decreased 24.14 9.87 30 242797 19811 56029429
Alopecia 24.02 9.87 1028 241799 292430 55756810
Cyst 23.97 9.87 114 242713 12664 56036576
Haemophagocytic lymphohistiocytosis 23.72 9.87 6 242821 9566 56039674
Inappropriate antidiuretic hormone secretion 23.72 9.87 15 242812 13741 56035499
Therapeutic response decreased 23.70 9.87 132 242695 52626 55996614
Rheumatic fever 23.69 9.87 56 242771 28771 56020469
Cestode infection 23.66 9.87 15 242812 272 56048968
Parkinsonism 23.62 9.87 6 242821 9540 56039700
Schizophrenia 23.42 9.87 8 242819 10491 56038749
Cerebral haemorrhage 23.16 9.87 56 242771 28550 56020690
Haemodynamic instability 23.15 9.87 4 242823 8325 56040915
Spinal meningioma benign 23.05 9.87 11 242816 110 56049130
Neutropenic sepsis 22.99 9.87 19 242808 15166 56034074
Device dislocation 22.78 9.87 39 242788 22567 56026673
Psychotic disorder 22.52 9.87 42 242785 23516 56025724
Pain in extremity 22.50 9.87 1530 241297 295901 55753339
Product substitution issue 22.44 9.87 18 242809 14581 56034659
Swollen joint count increased 22.35 9.87 44 242783 24140 56025100
Pneumocystis jirovecii pneumonia 22.14 9.87 21 242806 15680 56033560
Foetal death 22.03 9.87 5 242822 8582 56040658
Haematoma 21.94 9.87 68 242759 31951 56017289
Premature delivery 21.89 9.87 53 242774 27007 56022233
Sinus congestion 21.76 9.87 129 242698 15595 56033645
Posterior reversible encephalopathy syndrome 21.75 9.87 22 242805 15938 56033302
Facet joint syndrome 21.61 9.87 71 242756 6646 56042594
Intentional overdose 21.46 9.87 189 242638 67928 55981312
Colitis microscopic 21.42 9.87 4 242823 7871 56041369
Injection site reaction 21.40 9.87 138 242689 53109 55996131
Thrombotic microangiopathy 21.29 9.87 7 242820 9404 56039836
Magnesium deficiency 21.11 9.87 18 242809 523 56048717
Respiratory depression 20.84 9.87 14 242813 12421 56036819
Cerebral infarction 20.75 9.87 41 242786 22464 56026776
Feeling hot 20.59 9.87 273 242554 41514 56007726
Haematemesis 20.48 9.87 60 242767 28698 56020542
Diarrhoea 20.37 9.87 3094 239733 635413 55413827
Akathisia 20.36 9.87 6 242821 8646 56040594
Scoliosis 20.30 9.87 71 242756 6862 56042378
Stevens-Johnson syndrome 20.28 9.87 42 242785 22621 56026619
Neurotoxicity 20.16 9.87 23 242804 15772 56033468
Jaundice 20.13 9.87 56 242771 27238 56022002
Weight fluctuation 19.97 9.87 78 242749 7950 56041290
Ear pruritus 19.91 9.87 41 242786 2887 56046353
Hypercalcaemia 19.60 9.87 51 242776 25360 56023880
Oliguria 19.59 9.87 6 242821 8434 56040806
Injection site swelling 19.59 9.87 109 242718 43469 56005771
Face oedema 19.37 9.87 31 242796 18421 56030819
Acute respiratory distress syndrome 19.32 9.87 41 242786 21885 56027355
Off label use 19.27 9.87 2103 240724 554077 55495163
Hepatic enzyme increased 19.25 9.87 914 241913 170470 55878770
Breast cancer female 19.23 9.87 15 242812 12323 56036917
Type 2 diabetes mellitus 19.06 9.87 121 242706 46741 56002499
Bronchopulmonary aspergillosis 18.96 9.87 6 242821 8258 56040982
Productive cough 18.77 9.87 344 242483 55888 55993352
Hyperglycaemia 18.75 9.87 93 242734 38188 56011052
Diabetic ketoacidosis 18.61 9.87 33 242794 18838 56030402
Hypertensive crisis 18.40 9.87 20 242807 14016 56035224
Peritonitis 18.19 9.87 26 242801 16176 56033064
Left ventricular dysfunction 18.01 9.87 13 242814 11110 56038130
Injection site warmth 17.90 9.87 21 242806 14222 56035018
Disseminated intravascular coagulation 17.89 9.87 31 242796 17854 56031386
Mydriasis 17.84 9.87 13 242814 11058 56038182
Live birth 17.83 9.87 36 242791 19569 56029671
Therapeutic response shortened 17.80 9.87 84 242743 9302 56039938
Hepatic failure 17.78 9.87 79 242748 33407 56015833
Polyneuropathy 17.77 9.87 18 242809 13032 56036208
Injection site pruritus 17.72 9.87 107 242720 41824 56007416
Urinary sediment present 17.62 9.87 32 242795 2052 56047188
White blood cells urine positive 17.51 9.87 53 242774 4749 56044491
Bronchial secretion retention 17.50 9.87 30 242797 1838 56047402
Seasonal allergy 17.41 9.87 130 242697 16978 56032262
Treatment noncompliance 17.30 9.87 77 242750 32546 56016694
Graft versus host disease 17.29 9.87 4 242823 6777 56042463
Anxiety 17.22 9.87 1008 241819 192164 55857076
Dry eye 17.05 9.87 232 242595 35484 56013756
Osteosclerosis 16.86 9.87 44 242783 3619 56045621
Peripheral venous disease 16.83 9.87 87 242740 9992 56039248
Glossodynia 16.77 9.87 515 242312 151943 55897297
Hallucination, auditory 16.74 9.87 15 242812 11509 56037731
Infusion site extravasation 16.69 9.87 75 242752 8135 56041105
Acute generalised exanthematous pustulosis 16.69 9.87 11 242816 9858 56039382
Lip pruritus 16.61 9.87 19 242808 794 56048446
Neuroleptic malignant syndrome 16.60 9.87 15 242812 11463 56037777
Foetal growth restriction 16.56 9.87 5 242822 7094 56042146
Dermatitis bullous 16.50 9.87 6 242821 7567 56041673
Acute myeloid leukaemia 16.45 9.87 30 242797 16942 56032298
Aplastic anaemia 16.43 9.87 9 242818 8919 56040321
Product tampering 16.37 9.87 11 242816 221 56049019
Drug withdrawal syndrome 16.28 9.87 57 242770 25800 56023440
Blood urine present 16.14 9.87 107 242720 13448 56035792
Chronic obstructive pulmonary disease 16.06 9.87 342 242485 57073 55992167
Product use issue 15.99 9.87 648 242179 185393 55863847
Sudden death 15.91 9.87 11 242816 9614 56039626
Hepatitis 15.74 9.87 89 242738 35352 56013888
Genital haemorrhage 15.71 9.87 5 242822 6857 56042383
Femur fracture 15.71 9.87 102 242725 39193 56010047
Sneezing 15.70 9.87 118 242709 15442 56033798
Purpura 15.65 9.87 13 242814 10349 56038891
Arteriovenous fistula occlusion 15.59 9.87 13 242814 366 56048874
Abnormal behaviour 15.40 9.87 41 242786 20231 56029009
Liver disorder 15.39 9.87 120 242707 44250 56004990
Unintentional medical device removal 15.26 9.87 3 242824 5691 56043549
Menstruation delayed 15.14 9.87 25 242802 1485 56047755
Deep vein thrombosis postoperative 15.11 9.87 45 242782 3996 56045244
Concussion 15.06 9.87 73 242754 8173 56041067
Tenosynovitis 15.00 9.87 19 242808 12442 56036798
Dystonia 14.89 9.87 19 242808 12402 56036838
Infusion site pain 14.82 9.87 106 242721 13656 56035584
Full blood count decreased 14.78 9.87 160 242667 23189 56026051
Sputum discoloured 14.77 9.87 109 242718 14183 56035057
Corneal epithelium defect 14.75 9.87 12 242815 326 56048914
Miosis 14.75 9.87 5 242822 6587 56042653
Pulmonary fibrosis 14.74 9.87 72 242755 29686 56019554
Jaundice cholestatic 14.59 9.87 3 242824 5516 56043724
Cataract 14.57 9.87 306 242521 50941 55998299
Proteinuria 14.54 9.87 34 242793 17536 56031704
Aspergillus infection 14.52 9.87 7 242820 7458 56041782
Epstein-Barr virus infection 14.51 9.87 7 242820 7456 56041784
Body height decreased 14.46 9.87 78 242749 9107 56040133
Loss of consciousness 14.44 9.87 360 242467 108989 55940251
Ischaemic stroke 14.42 9.87 32 242795 16810 56032430
Pathogen resistance 14.41 9.87 4 242823 5996 56043244
Oligohydramnios 14.39 9.87 4 242823 5990 56043250
Device use error 14.36 9.87 3 242824 5453 56043787
Large intestine perforation 14.32 9.87 8 242819 7843 56041397
Cognitive disorder 14.32 9.87 139 242688 48994 56000246
Urogenital prolapse 14.29 9.87 5 242822 20 56049220
Muscle spasms 14.25 9.87 727 242100 136644 55912596
Aggression 14.20 9.87 48 242779 21958 56027282
Myelodysplastic syndrome 14.19 9.87 31 242796 16375 56032865
Dry mouth 14.14 9.87 370 242457 63835 55985405
Femoral neck fracture 14.06 9.87 8 242819 7763 56041477
Tubulointerstitial nephritis 13.99 9.87 32 242795 16633 56032607
Haemodialysis 13.96 9.87 10 242817 8581 56040659
Bacterial test 13.95 9.87 21 242806 1152 56048088
Ventricular fibrillation 13.92 9.87 16 242811 10936 56038304
Body temperature fluctuation 13.88 9.87 29 242798 2063 56047177
Premenstrual syndrome 13.85 9.87 16 242811 676 56048564
Ascites 13.75 9.87 100 242727 37444 56011796
Enthesopathy 13.62 9.87 9 242818 8054 56041186
Vein collapse 13.56 9.87 18 242809 878 56048362
Creatinine urine decreased 13.47 9.87 9 242818 179 56049061
Migraine 13.43 9.87 479 242348 86318 55962922
Infusion site erythema 13.42 9.87 79 242748 9527 56039713
Hypomagnesaemia 13.29 9.87 59 242768 24956 56024284
Rash erythematous 13.24 9.87 230 242597 36991 56012249
Mite allergy 13.22 9.87 14 242813 536 56048704
Bradyphrenia 13.20 9.87 6 242821 6614 56042626
Stress cardiomyopathy 13.16 9.87 10 242817 8326 56040914
Muscle rigidity 13.13 9.87 16 242811 10655 56038585
Macular degeneration 13.07 9.87 40 242787 18868 56030372
Eye infection viral 13.07 9.87 8 242819 136 56049104
Hyperthermia 13.00 9.87 10 242817 8275 56040965
Enteritis 12.99 9.87 8 242819 7435 56041805
Lichen sclerosus 12.97 9.87 19 242808 1017 56048223
Delirium 12.94 9.87 119 242708 42398 56006842
Culture urine positive 12.92 9.87 39 242788 3489 56045751
Transaminases increased 12.91 9.87 72 242755 28698 56020542
Drug level increased 12.84 9.87 46 242781 20679 56028561
Blue toe syndrome 12.82 9.87 12 242815 395 56048845
Nerve compression 12.71 9.87 69 242758 8075 56041165
Staphylococcal sepsis 12.69 9.87 8 242819 7341 56041899
Drug dependence 12.68 9.87 52 242775 22481 56026759
Post-traumatic neck syndrome 12.64 9.87 27 242800 1951 56047289
Device related infection 12.62 9.87 50 242777 21830 56027410
Neuralgia 12.60 9.87 157 242670 23538 56025702
Specific gravity urine increased 12.57 9.87 9 242818 201 56049039
Finger deformity 12.57 9.87 59 242768 6518 56042722
Poor quality sleep 12.34 9.87 124 242703 17631 56031609
International normalised ratio increased 12.25 9.87 126 242701 43915 56005325
Tardive dyskinesia 12.22 9.87 10 242817 8021 56041219
Libido increased 12.20 9.87 21 242806 1291 56047949
Blood calcium decreased 12.07 9.87 57 242770 23712 56025528
Hypothyroidism 12.02 9.87 106 242721 38090 56011150
Muscle strain 11.98 9.87 64 242763 7444 56041796
Injection site haematoma 11.95 9.87 6 242821 6246 56042994
Hyperbilirubinaemia 11.91 9.87 16 242811 10219 56039021
Breast cancer stage I 11.88 9.87 6 242821 6224 56043016
Respiratory tract congestion 11.87 9.87 111 242716 15480 56033760
Stillbirth 11.83 9.87 6 242821 6208 56043032
Breast cancer stage II 11.82 9.87 5 242822 5753 56043487
Juvenile idiopathic arthritis 11.81 9.87 3 242824 4770 56044470
Hyperthyroidism 11.73 9.87 25 242802 13327 56035913
Cardiovascular disorder 11.71 9.87 18 242809 10871 56038369
Shock 11.70 9.87 51 242776 21677 56027563
Cardiogenic shock 11.67 9.87 34 242793 16291 56032949
Blood bilirubin increased 11.66 9.87 90 242737 33264 56015976
Soft tissue injury 11.60 9.87 23 242804 1576 56047664
Hypertransaminasaemia 11.57 9.87 3 242824 4704 56044536
Second primary malignancy 11.53 9.87 9 242818 7393 56041847
Liver injury 11.53 9.87 120 242707 41728 56007512
Ventricular tachycardia 11.51 9.87 36 242791 16865 56032375
Dysarthria 11.48 9.87 112 242715 39438 56009802
Hyperadrenalism 11.43 9.87 4 242823 16 56049224
No adverse event 11.42 9.87 101 242726 36273 56012967
Urine ketone body present 11.41 9.87 29 242798 2348 56046892
Tooth disorder 11.39 9.87 164 242663 25389 56023851
Oligomenorrhoea 11.37 9.87 15 242812 727 56048513
Hallucination, visual 11.34 9.87 38 242789 17430 56031810
Encephalitis 11.20 9.87 11 242816 8079 56041161
Limb injury 11.18 9.87 146 242681 22124 56027116
Metastases to lung 11.10 9.87 21 242806 11697 56037543
Endometrial disorder 11.10 9.87 14 242813 649 56048591
Atypical femur fracture 11.00 9.87 4 242823 5043 56044197
Vitamin D decreased 10.99 9.87 72 242755 9011 56040229
Pancreatitis 10.95 9.87 133 242694 44947 56004293
Hypoalbuminaemia 10.94 9.87 18 242809 10581 56038659
Red blood cell sedimentation rate increased 10.93 9.87 103 242724 36520 56012720
Skin ulcer 10.93 9.87 110 242717 38498 56010742
Eczema 10.91 9.87 67 242760 26086 56023154
Weight decreased 10.89 9.87 1192 241635 239522 55809718
Necrosis 10.89 9.87 4 242823 5012 56044228
Hepatitis acute 10.85 9.87 12 242815 8345 56040895
Electrocardiogram QRS complex prolonged 10.83 9.87 5 242822 5462 56043778
Complication of device removal 10.83 9.87 3 242824 4501 56044739
Metastases to liver 10.82 9.87 52 242775 21534 56027706
Nephrogenic systemic fibrosis 10.68 9.87 3 242824 4462 56044778
Hyperammonaemia 10.62 9.87 4 242823 4936 56044304
Mania 10.61 9.87 21 242806 11499 56037741
Pulmonary embolism 10.56 9.87 367 242460 106757 55942483
Sternal fracture 10.55 9.87 26 242801 2064 56047176
Device malfunction 10.55 9.87 35 242792 16101 56033139
Faecaloma 10.44 9.87 10 242817 7431 56041809
Asphyxia 10.42 9.87 6 242821 5783 56043457
Anterior chamber cell 10.35 9.87 12 242815 509 56048731
Blood potassium increased 10.34 9.87 117 242710 17144 56032096
Urine analysis abnormal 10.28 9.87 44 242783 4673 56044567
Cushingoid 10.27 9.87 10 242817 7374 56041866
Dermatitis exfoliative 10.26 9.87 5 242822 5294 56043946
Multiple allergies 10.26 9.87 79 242748 10417 56038823
Ulcer 10.24 9.87 56 242771 22429 56026811
Disease progression 10.21 9.87 361 242466 104812 55944428
Peripheral sensory neuropathy 10.17 9.87 9 242818 6947 56042293
Polymenorrhoea 10.13 9.87 18 242809 1135 56048105
Gangrene 10.08 9.87 49 242778 5491 56043749
Cutaneous vasculitis 10.07 9.87 4 242823 4780 56044460
Limb mass 10.07 9.87 32 242795 2944 56046296
Musculoskeletal pain 10.01 9.87 437 242390 80715 55968525
Pulmonary arterial hypertension 9.99 9.87 70 242757 26433 56022807
Bronchitis 9.99 9.87 586 242241 111725 55937515
Vital capacity decreased 9.92 9.87 19 242808 1269 56047971

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Infusion related reaction 273.86 10.44 491 89767 47564 31559522
Drug interaction 245.52 10.44 145 90113 208398 31398688
Fatigue 150.67 10.44 1535 88723 333671 31273415
Toxicity to various agents 118.20 10.44 210 90048 181277 31425809
Chills 112.04 10.44 463 89795 73687 31533399
Back pain 102.61 10.44 596 89662 108817 31498269
Blood pressure increased 96.02 10.44 465 89793 79168 31527918
Pain 86.75 10.44 862 89396 185897 31421189
Cough 84.16 10.44 664 89594 134150 31472936
Blood pressure diastolic abnormal 83.84 10.44 78 90180 3901 31603185
Acute kidney injury 83.48 10.44 462 89796 279252 31327834
Arthralgia 79.27 10.44 717 89541 150707 31456379
Cardiac failure 67.90 10.44 87 90171 85866 31521220
Rhabdomyolysis 65.53 10.44 51 90207 63530 31543556
Heart rate decreased 64.44 10.44 202 90056 28064 31579022
Blood pressure fluctuation 63.83 10.44 175 90083 22561 31584525
General physical health deterioration 59.67 10.44 148 90110 113287 31493799
Sinusitis 59.24 10.44 234 90024 36462 31570624
Completed suicide 54.98 10.44 111 90147 91403 31515683
Hyperkalaemia 54.13 10.44 62 90196 64289 31542797
Blood pressure systolic abnormal 52.83 10.44 54 90204 3033 31604053
Headache 51.99 10.44 772 89486 182880 31424206
C-reactive protein increased 51.43 10.44 38 90220 48612 31558474
Pain in extremity 48.91 10.44 526 89732 115677 31491409
Drug resistance 46.35 10.44 6 90252 23447 31583639
Cholestasis 45.91 10.44 8 90250 25067 31582019
Chest discomfort 45.59 10.44 268 89990 49101 31557985
Flushing 45.34 10.44 188 90070 29940 31577146
Drug reaction with eosinophilia and systemic symptoms 44.40 10.44 15 90243 30003 31577083
Blood pressure systolic increased 43.33 10.44 138 90120 19332 31587754
Rhinorrhoea 42.31 10.44 153 90105 22859 31584227
Lactic acidosis 42.22 10.44 19 90239 31918 31575168
Thrombocytopenia 41.78 10.44 237 90021 142510 31464576
Oxygen saturation decreased 41.78 10.44 261 89997 48854 31558232
Agranulocytosis 40.65 10.44 6 90252 21241 31585845
Peripheral swelling 40.48 10.44 331 89927 67534 31539552
Multiple organ dysfunction syndrome 39.04 10.44 85 90173 68118 31538968
Interstitial lung disease 39.02 10.44 72 90186 61331 31545755
Throat irritation 38.23 10.44 83 90175 9231 31597855
Urticaria 36.74 10.44 285 89973 57232 31549854
Abdominal discomfort 36.61 10.44 262 89996 51305 31555781
Hepatic function abnormal 36.56 10.44 38 90220 41184 31565902
Neutropenia 36.40 10.44 242 90016 140122 31466964
Pulmonary function test decreased 36.12 10.44 53 90205 4332 31602754
Cytomegalovirus infection 35.42 10.44 13 90245 24694 31582392
Weight decreased 34.39 10.44 643 89615 159309 31447777
Altered state of consciousness 33.89 10.44 9 90249 21042 31586044
Joint swelling 33.71 10.44 264 89994 53167 31553919
Rash 33.53 10.44 780 89478 200706 31406380
Hypoglycaemia 32.14 10.44 60 90198 50886 31556200
Renal impairment 31.84 10.44 132 90126 86217 31520869
Sleep disorder due to general medical condition, insomnia type 30.52 10.44 27 90231 1264 31605822
Vitamin D deficiency 30.45 10.44 58 90200 5874 31601212
Coma 30.11 10.44 44 90214 41106 31565980
Chronic obstructive pulmonary disease 30.07 10.44 226 90032 44940 31562146
Pancreatitis acute 29.74 10.44 18 90240 25582 31581504
Hyperhidrosis 29.70 10.44 308 89950 67085 31540001
Nausea 29.58 10.44 1113 89145 306834 31300252
Bone marrow failure 29.44 10.44 22 90236 27986 31579100
Bronchitis 29.41 10.44 200 90058 38517 31568569
Leukopenia 29.18 10.44 77 90181 57751 31549335
Neck pain 29.18 10.44 136 90122 22774 31584312
Septic shock 29.09 10.44 94 90164 66064 31541022
Circulatory collapse 28.97 10.44 10 90248 19734 31587352
Dyspnoea 28.95 10.44 1224 89034 342255 31264831
Nasopharyngitis 28.80 10.44 291 89967 62954 31544132
Heart rate increased 28.68 10.44 208 90050 40902 31566184
Maternal exposure before pregnancy 28.09 10.44 20 90238 681 31606405
Gamma-glutamyltransferase increased 27.80 10.44 23 90235 27802 31579284
Contusion 27.14 10.44 174 90084 32854 31574232
Epilepsy 27.06 10.44 13 90245 21028 31586058
Cerebral infarction 26.54 10.44 21 90237 25956 31581130
Pancytopenia 25.50 10.44 145 90113 87171 31519915
Bone pain 25.47 10.44 116 90142 19235 31587851
Foetal exposure during pregnancy 25.03 10.44 49 90209 40827 31566259
Nephrolithiasis 24.96 10.44 148 90110 27191 31579895
Myelosuppression 24.75 10.44 6 90252 14914 31592172
Musculoskeletal stiffness 24.33 10.44 201 90057 41124 31565962
Osteonecrosis 24.20 10.44 5 90253 13879 31593207
Melaena 23.80 10.44 35 90223 32619 31574467
Dental caries 23.26 10.44 43 90215 4258 31602828
Hospice care 23.24 10.44 50 90208 5526 31601560
Pruritus 23.13 10.44 492 89766 124675 31482411
Pleural thickening 22.69 10.44 13 90245 301 31606785
Pharyngeal paraesthesia 22.54 10.44 16 90242 542 31606544
Muscle spasms 22.42 10.44 295 89963 68023 31539063
Anxiety 22.40 10.44 374 89884 90659 31516427
Bradycardia 21.97 10.44 112 90146 69215 31537871
Feeling hot 21.88 10.44 98 90160 16135 31590951
Drug hypersensitivity 21.59 10.44 308 89950 72291 31534795
Depressed level of consciousness 21.35 10.44 49 90209 38552 31568534
Emotional distress 21.14 10.44 89 90169 14267 31592819
Labelled drug-drug interaction medication error 20.50 10.44 6 90252 13157 31593929
Asthenia 20.27 10.44 807 89451 223948 31383138
Condition aggravated 19.83 10.44 338 89920 163671 31443415
Rhinalgia 19.82 10.44 13 90245 386 31606700
Unevaluable event 19.79 10.44 152 90106 30423 31576663
Drug intolerance 19.79 10.44 231 90027 51802 31555284
Pneumocystis jirovecii pneumonia 19.62 10.44 14 90244 18237 31588849
Blood creatine phosphokinase increased 19.61 10.44 58 90200 41916 31565170
Dry skin 19.57 10.44 132 90126 25349 31581737
Throat tightness 19.53 10.44 57 90201 7612 31599474
Dyspepsia 19.52 10.44 159 90099 32394 31574692
Infusion site pruritus 19.25 10.44 15 90243 587 31606499
Osteoarthritis 19.23 10.44 106 90152 18961 31588125
Productive cough 19.13 10.44 162 90096 33378 31573708
Constipation 19.06 10.44 475 89783 123516 31483570
Product used for unknown indication 18.96 10.44 17 90241 810 31606276
Mucosal inflammation 18.80 10.44 44 90214 34383 31572703
Hip fracture 18.48 10.44 71 90187 10915 31596171
Oropharyngeal pain 18.46 10.44 153 90105 31330 31575756
Drug ineffective 18.43 10.44 930 89328 394643 31212443
Eosinophilia 17.87 10.44 24 90234 23229 31583857
Lymphocyte count abnormal 17.66 10.44 16 90242 773 31606313
Metabolic acidosis 17.55 10.44 56 90202 39521 31567565
Prostate cancer 17.53 10.44 52 90206 37549 31569537
Ascites 17.52 10.44 59 90199 40954 31566132
Intentional self-injury 17.47 10.44 8 90250 13307 31593779
Body temperature decreased 17.35 10.44 73 90185 11697 31595389
Hypoxia 17.24 10.44 219 90039 50094 31556992
Extrapyramidal disorder 17.22 10.44 6 90252 11772 31595314
Anaemia 17.11 10.44 470 89788 213052 31394034
Post concussion syndrome 16.96 10.44 8 90250 122 31606964
Product use issue 16.95 10.44 241 90017 56518 31550568
Neutropenic sepsis 16.94 10.44 7 90251 12372 31594714
Injury 16.91 10.44 105 90153 19604 31587482
Psoriasis 16.85 10.44 72 90186 46647 31560439
Upper-airway cough syndrome 16.58 10.44 31 90227 3096 31603990
Wheezing 16.57 10.44 166 90092 35820 31571266
Pneumonia 16.56 10.44 1137 89121 334175 31272911
C-reactive protein decreased 16.51 10.44 23 90235 1792 31605294
Blood pressure diastolic increased 16.32 10.44 37 90221 4236 31602850
Cerebral haemorrhage 16.31 10.44 44 90214 32768 31574318
Nephropathy toxic 16.23 10.44 6 90252 11347 31595739
Overdose 15.94 10.44 159 90099 84505 31522581
Paranasal sinus hypersecretion 15.88 10.44 16 90242 883 31606203
Drug eruption 15.86 10.44 17 90241 18170 31588916
Hypoaesthesia 15.59 10.44 235 90023 55787 31551299
Joint effusion 15.58 10.44 38 90220 4561 31602525
Jaundice 15.52 10.44 40 90218 30247 31576839
Nervous system neoplasm 15.52 10.44 8 90250 149 31606937
Toxic epidermal necrolysis 15.15 10.44 20 90238 19504 31587582
Urinary tract infection 15.12 10.44 305 89953 76564 31530522
Hyponatraemia 15.00 10.44 136 90122 73663 31533423
Musculoskeletal pain 14.92 10.44 140 90118 29688 31577398
Peritonitis 14.90 10.44 13 90245 15314 31591772
Delirium 14.84 10.44 64 90194 41357 31565729
Progressive multifocal leukoencephalopathy 14.71 10.44 4 90254 9209 31597877
Electrocardiogram QT prolonged 14.67 10.44 57 90201 37930 31569156
Diabetes mellitus 14.49 10.44 67 90191 42489 31564597
Graft versus host disease 14.15 10.44 6 90252 10441 31596645
Poor venous access 14.13 10.44 34 90224 4046 31603040
Joint stiffness 13.89 10.44 61 90197 9960 31597126
Failure to thrive 13.84 10.44 52 90206 7910 31599176
Weight increased 13.71 10.44 321 89937 82626 31524460
Bladder cancer 13.71 10.44 13 90245 14712 31592374
Hepatocellular carcinoma 13.62 10.44 4 90254 8752 31598334
Nasal congestion 13.57 10.44 102 90156 20279 31586807
Death 13.56 10.44 1197 89061 359372 31247714
Acute coronary syndrome 13.50 10.44 10 90248 12779 31594307
Haematochezia 13.38 10.44 175 90083 40289 31566797
Sputum discoloured 13.26 10.44 46 90212 6730 31600356
Miosis 13.17 10.44 4 90254 8566 31598520
Urethral meatus stenosis 13.03 10.44 5 90253 44 31607042
Arthritis 12.94 10.44 127 90131 27258 31579828
Aplastic anaemia 12.93 10.44 5 90253 9198 31597888
Hypocalcaemia 12.89 10.44 27 90231 21951 31585135
Treatment failure 12.86 10.44 66 90192 40726 31566360
Paranasal sinus discomfort 12.79 10.44 13 90245 725 31606361
Polyneuropathy 12.72 10.44 11 90247 13011 31594075
Anuria 12.72 10.44 6 90252 9808 31597278
Chest pain 12.71 10.44 429 89829 116528 31490558
Cardio-respiratory arrest 12.49 10.44 91 90167 51635 31555451
Tubulointerstitial nephritis 12.36 10.44 21 90237 18475 31588611
Dizziness 12.34 10.44 689 89569 198458 31408628
Full blood count decreased 12.29 10.44 85 90173 16455 31590631
Liver disorder 11.84 10.44 44 90214 29663 31577423
Fear 11.82 10.44 58 90200 9916 31597170
Acute respiratory failure 11.77 10.44 127 90131 27928 31579158
Psychotic disorder 11.77 10.44 29 90229 22264 31584822
Hepatic encephalopathy 11.67 10.44 13 90245 13658 31593428
Aortic bruit 11.67 10.44 7 90251 177 31606909
Tooth disorder 11.66 10.44 58 90200 9971 31597115
Anhedonia 11.63 10.44 47 90211 7395 31599691
Impaired work ability 11.59 10.44 40 90218 5837 31601249
Ischaemic stroke 11.59 10.44 19 90239 16952 31590134
Haematotoxicity 11.59 10.44 3 90255 7134 31599952
Hypomagnesaemia 11.53 10.44 23 90235 19035 31588051
Anaphylactic shock 11.49 10.44 14 90244 14131 31592955
Disseminated intravascular coagulation 11.41 10.44 26 90232 20511 31586575
Hot flush 11.32 10.44 82 90176 16114 31590972
Blood pressure diastolic decreased 11.27 10.44 49 90209 7964 31599122
Hypersensitivity 11.23 10.44 222 90036 55521 31551565
Increased tendency to bruise 11.18 10.44 29 90229 3616 31603470
Red blood cell count decreased 11.09 10.44 121 90137 26686 31580400
Myocardial ischaemia 11.07 10.44 19 90239 16648 31590438
Therapy non-responder 11.06 10.44 54 90204 33757 31573329
Radial pulse abnormal 11.00 10.44 3 90255 7 31607079
Bile output abnormal 10.98 10.44 4 90254 30 31607056
Lymphocyte count 10.98 10.44 5 90253 70 31607016
Parkinsonian rest tremor 10.96 10.44 6 90252 127 31606959
Iron deficiency 10.93 10.44 27 90231 3267 31603819
Thymic cancer metastatic 10.92 10.44 5 90253 71 31607015
Thrombosis 10.91 10.44 185 90073 44966 31562120
Sinus disorder 10.85 10.44 41 90217 6254 31600832
Purpura 10.82 10.44 7 90251 9603 31597483
Appendix disorder 10.79 10.44 11 90247 616 31606470
Haemarthrosis 10.73 10.44 25 90233 2914 31604172
White blood cell count decreased 10.64 10.44 325 89933 87073 31520013
Nightmare 10.63 10.44 65 90193 12072 31595014
Cardiac arrest 10.60 10.44 184 90074 88878 31518208
Cytomegalovirus viraemia 10.59 10.44 3 90255 6722 31600364
Loss of personal independence in daily activities 10.57 10.44 43 90215 28245 31578841
Flatulence 10.53 10.44 91 90167 18857 31588229
Penile torsion 10.46 10.44 3 90255 9 31607077

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug interaction 689.81 9.75 275 262339 381166 70284664
Infusion related reaction 474.70 9.75 1709 260905 195825 70470005
Toxicity to various agents 432.02 9.75 467 262147 381705 70284125
Sinusitis 392.14 9.75 1447 261167 167748 70498082
Irritable bowel syndrome 337.90 9.75 645 261969 50205 70615625
Muscle injury 319.47 9.75 538 262076 37956 70627874
Peripheral swelling 309.22 9.75 1707 260907 234856 70430974
Nasopharyngitis 306.37 9.75 1627 260987 220579 70445251
Pain 306.08 9.75 3613 259001 625203 70040627
Folliculitis 291.53 9.75 547 262067 42023 70623807
Acute kidney injury 286.45 9.75 857 261757 473767 70192063
Completed suicide 275.23 9.75 261 262353 226874 70438956
Sleep disorder due to general medical condition, insomnia type 272.41 9.75 481 262133 35251 70630579
Fatigue 261.34 9.75 4390 258224 819929 69845901
Lower respiratory tract infection 237.54 9.75 931 261683 110982 70554848
Back pain 213.12 9.75 1724 260890 269428 70396402
Headache 212.51 9.75 3168 259446 577237 70088593
Pruritus 206.57 9.75 2070 260544 343490 70322340
Blood pressure fluctuation 204.98 9.75 580 262034 58432 70607398
Blood pressure increased 197.90 9.75 1285 261329 187232 70478598
Weight increased 197.63 9.75 1554 261060 240777 70425053
Ill-defined disorder 195.02 9.75 543 262071 54198 70611632
Blood pressure diastolic abnormal 194.78 9.75 263 262351 15241 70650589
Impaired healing 186.48 9.75 653 261961 73721 70592109
Gastrointestinal disorder 186.11 9.75 829 261785 104598 70561232
Joint swelling 182.45 9.75 1579 261035 251632 70414198
Ear pain 180.74 9.75 348 262266 27251 70638579
Body temperature increased 177.76 9.75 430 262184 39404 70626426
Arthralgia 172.64 9.75 2718 259896 500672 70165158
Muscle spasticity 163.09 9.75 275 262339 19414 70646416
Cardiac failure 161.20 9.75 176 262438 143365 70522465
Contusion 157.19 9.75 909 261705 127127 70538703
Blood pressure systolic increased 152.50 9.75 513 262101 56746 70609084
Blister 151.48 9.75 755 261859 99771 70566059
Rhabdomyolysis 146.87 9.75 86 262528 95674 70570156
Neutropenia 139.71 9.75 486 262128 256670 70409160
Night sweats 136.97 9.75 414 262200 43270 70622560
Blood pressure systolic abnormal 135.55 9.75 201 262413 12708 70653122
Thrombocytopenia 134.58 9.75 445 262169 238665 70427165
Urticaria 134.12 9.75 1048 261566 162001 70503829
Heart rate increased 132.49 9.75 757 261857 105391 70560439
Hepatocellular injury 132.33 9.75 10 262604 46081 70619749
Hyperkalaemia 128.40 9.75 123 262491 106468 70559362
Helicobacter infection 127.05 9.75 474 262140 55182 70610648
General physical health deterioration 124.91 9.75 451 262163 235580 70430250
Lactic acidosis 123.76 9.75 43 262571 64981 70600849
Drug reaction with eosinophilia and systemic symptoms 121.93 9.75 32 262582 57981 70607849
Cholestasis 115.87 9.75 19 262595 47853 70617977
Hypersensitivity 113.15 9.75 1325 261289 228487 70437343
Anaemia 111.63 9.75 956 261658 402467 70263363
Stomatitis 111.23 9.75 836 261778 127675 70538155
Drug resistance 110.46 9.75 8 262606 38182 70627648
Pancytopenia 107.47 9.75 251 262363 150856 70514974
Duodenal ulcer perforation 104.98 9.75 421 262193 50691 70615139
Agranulocytosis 102.11 9.75 14 262600 40284 70625546
Oxygen saturation decreased 101.09 9.75 758 261856 115671 70550159
Multiple organ dysfunction syndrome 100.22 9.75 154 262460 108361 70557469
Temperature regulation disorder 98.74 9.75 101 262513 4343 70661487
Hyponatraemia 97.76 9.75 287 262327 159800 70506030
Bursitis 96.37 9.75 266 262348 26407 70639423
Hepatic function abnormal 94.81 9.75 68 262546 67928 70597902
Leukopenia 93.90 9.75 156 262458 106404 70559426
Coma 93.09 9.75 122 262492 91722 70574108
Pain in extremity 89.97 9.75 1710 260904 326372 70339458
Chest discomfort 89.10 9.75 775 261839 123606 70542224
Bone marrow failure 88.90 9.75 35 262579 48975 70616855
Cytomegalovirus infection 87.31 9.75 20 262594 39738 70626092
Electrocardiogram QT prolonged 86.64 9.75 109 262505 83408 70582422
Insomnia 86.49 9.75 1207 261407 216599 70449231
Epilepsy 84.20 9.75 20 262594 38764 70627066
Chills 84.19 9.75 863 261751 143923 70521907
Respiratory disorder 84.17 9.75 327 262287 38796 70627034
C-reactive protein increased 83.13 9.75 178 262436 110339 70555491
Septic shock 82.62 9.75 183 262431 112075 70553755
Flushing 82.40 9.75 554 262060 81618 70584212
Osteoarthritis 82.37 9.75 513 262101 73634 70592196
Oropharyngeal pain 81.89 9.75 624 261990 95686 70570144
Circulatory collapse 81.69 9.75 16 262598 35458 70630372
Pleural thickening 81.09 9.75 74 262540 2758 70663072
Altered state of consciousness 80.52 9.75 24 262590 39998 70625832
Hypoglycaemia 79.62 9.75 142 262472 94222 70571608
Heart rate decreased 79.15 9.75 445 262169 61570 70604260
Swelling 79.00 9.75 1055 261559 187484 70478346
Cardiac arrest 78.94 9.75 314 262300 159520 70506310
Depressed level of consciousness 78.90 9.75 126 262488 87305 70578525
Cough 73.76 9.75 1649 260965 323728 70342102
Food allergy 71.85 9.75 120 262494 8404 70657426
Bradycardia 71.37 9.75 230 262384 124385 70541445
Mucosal inflammation 70.96 9.75 88 262526 67762 70598068
Therapeutic product effect decreased 70.05 9.75 824 261790 142194 70523636
Pleural fibrosis 69.20 9.75 81 262533 4058 70661772
Renal impairment 69.04 9.75 286 262328 143651 70522179
Presbyacusis 67.99 9.75 65 262549 2572 70663258
Abdominal discomfort 67.68 9.75 1144 261470 213514 70452316
Toxic epidermal necrolysis 67.35 9.75 31 262583 39526 70626304
Interstitial lung disease 67.34 9.75 183 262431 104502 70561328
Myelosuppression 66.53 9.75 15 262599 30130 70635700
Cardio-respiratory arrest 66.27 9.75 174 262440 100503 70565327
Discomfort 64.43 9.75 635 261979 104801 70561029
Metabolic acidosis 63.51 9.75 111 262503 74235 70591595
Overdose 63.12 9.75 369 262245 169376 70496454
Pancreatitis acute 62.04 9.75 46 262568 45178 70620652
Gamma-glutamyltransferase increased 60.43 9.75 59 262555 50626 70615204
Rheumatoid arthritis 60.28 9.75 1460 261154 290345 70375485
Melaena 60.08 9.75 72 262542 56283 70609547
Angioedema 59.15 9.75 97 262517 66513 70599317
Blood magnesium increased 58.73 9.75 67 262547 3264 70662566
Osteonecrosis of jaw 58.48 9.75 40 262574 40962 70624868
Hepatic enzyme increased 58.30 9.75 860 261754 156130 70509700
Rhinorrhoea 56.96 9.75 431 262183 65940 70599890
Rash 56.94 9.75 2371 260243 508191 70157639
Seizure 56.92 9.75 405 262209 177557 70488273
Blood pressure diastolic increased 56.60 9.75 135 262479 12256 70653574
Dyspnoea 55.41 9.75 3428 259186 766632 69899198
Throat irritation 55.17 9.75 268 262346 35036 70630794
Hypotension 54.44 9.75 1113 261501 403268 70262562
Influenza 53.87 9.75 651 261963 113049 70552781
Labelled drug-drug interaction medication error 51.29 9.75 13 262601 24114 70641716
Poisoning deliberate 51.03 9.75 3 262611 17057 70648773
Rash maculo-papular 50.33 9.75 68 262546 50477 70615353
Blood pressure diastolic decreased 49.49 9.75 208 262406 25572 70640258
Jaundice 49.30 9.75 68 262546 50040 70615790
Arthropathy 49.21 9.75 805 261809 149252 70516578
Blood creatine phosphokinase increased 49.18 9.75 95 262519 61168 70604662
Hypocalcaemia 48.15 9.75 57 262557 44802 70621028
Cerebral infarction 47.96 9.75 53 262561 42956 70622874
Intentional self-injury 47.70 9.75 29 262585 31621 70634209
Coeliac disease 47.44 9.75 104 262510 8929 70656901
Eosinophilia 46.84 9.75 48 262566 40271 70625559
Asthenia 45.58 9.75 2101 260513 455565 70210265
Urine abnormality 45.51 9.75 94 262520 7744 70658086
Orthostatic hypotension 45.34 9.75 76 262538 51667 70614163
Feeling hot 45.15 9.75 322 262292 48348 70617482
Osteonecrosis 44.96 9.75 26 262588 29134 70636696
Infection 44.21 9.75 1057 261557 209728 70456102
Anxiety 44.15 9.75 1098 261516 219232 70446598
Lip dry 44.04 9.75 106 262508 9679 70656151
Cerebral haemorrhage 43.70 9.75 83 262531 53781 70612049
Drug eruption 43.68 9.75 49 262565 39447 70626383
Nephropathy toxic 43.37 9.75 8 262606 18506 70647324
Nasal congestion 43.31 9.75 402 262212 65270 70600560
Skin necrosis 42.87 9.75 5 262609 16286 70649544
Pericarditis 42.78 9.75 491 262123 84214 70581616
Hypokalaemia 42.21 9.75 298 262316 130890 70534940
Device expulsion 41.83 9.75 15 262599 22231 70643599
Renal failure 41.70 9.75 473 262141 188597 70477233
Abdominal pain upper 41.56 9.75 974 261640 192628 70473202
Osteopenia 41.30 9.75 146 262468 16551 70649279
Wound 40.71 9.75 551 262063 98181 70567649
Anti-cyclic citrullinated peptide antibody positive 40.60 9.75 418 262196 69767 70596063
Drug-induced liver injury 40.03 9.75 93 262521 56020 70609810
Torsade de pointes 40.00 9.75 9 262605 18107 70647723
Parkinsonism 39.60 9.75 5 262609 15320 70650510
Hand deformity 39.16 9.75 491 262123 85991 70579839
Haematotoxicity 39.16 9.75 3 262611 13671 70652159
Neovascularisation 38.96 9.75 33 262581 1112 70664718
Urine leukocyte esterase positive 38.62 9.75 57 262557 3588 70662242
Pneumocystis jirovecii pneumonia 38.25 9.75 33 262581 30049 70635781
Drug abuse 37.97 9.75 355 262259 146901 70518929
Generalised tonic-clonic seizure 37.61 9.75 60 262554 41601 70624229
Migraine 37.50 9.75 421 262193 71817 70594013
Weight decreased 37.10 9.75 1453 261161 309035 70356795
Graft versus host disease 36.27 9.75 6 262608 15017 70650813
Status epilepticus 36.23 9.75 23 262591 24503 70641327
Shock haemorrhagic 36.16 9.75 11 262603 18095 70647735
Red cell distribution width increased 36.03 9.75 122 262492 13535 70652295
Neutropenic sepsis 35.71 9.75 24 262590 24806 70641024
Cyst 35.67 9.75 116 262498 12603 70653227
Ascites 35.06 9.75 130 262484 67417 70598413
Productive cough 34.72 9.75 443 262171 77894 70587936
Illness 34.70 9.75 219 262395 31572 70634258
Malignant neoplasm progression 34.69 9.75 286 262328 121453 70544377
Hepatic failure 34.65 9.75 104 262510 57521 70608309
Immunodeficiency 33.98 9.75 142 262472 17413 70648417
Hepatotoxicity 33.77 9.75 70 262544 43916 70621914
Poisoning 33.71 9.75 21 262593 22601 70643229
Dyskinesia 33.57 9.75 63 262551 41011 70624819
Neck pain 33.48 9.75 386 262228 66271 70599559
Epigastric discomfort 33.25 9.75 79 262535 7154 70658676
Facet joint syndrome 32.81 9.75 71 262543 6042 70659788
Inappropriate antidiuretic hormone secretion 32.81 9.75 23 262591 23253 70642577
Product prescribing error 32.50 9.75 59 262555 38893 70626937
Haemodynamic instability 32.21 9.75 9 262605 15649 70650181
Syncope 32.20 9.75 426 262188 165283 70500547
Deafness neurosensory 32.19 9.75 74 262540 6558 70659272
Sleep disorder 32.19 9.75 398 262216 69474 70596356
Posterior reversible encephalopathy syndrome 31.97 9.75 26 262588 24376 70641454
Contraindicated product administered 31.95 9.75 687 261927 133925 70531905
Condition aggravated 31.72 9.75 1278 261336 426357 70239473
Disorientation 31.71 9.75 109 262505 57814 70608016
Lower limb fracture 31.17 9.75 134 262480 16638 70649192
Miosis 31.15 9.75 7 262607 14094 70651736
Prostate cancer 30.95 9.75 42 262572 31121 70634709
Psychotic disorder 30.66 9.75 58 262556 37643 70628187
Drug level increased 30.64 9.75 55 262559 36414 70629416
Bronchopulmonary aspergillosis 30.61 9.75 20 262594 20982 70644848
Oliguria 30.32 9.75 9 262605 15042 70650788
Lymphopenia 30.19 9.75 34 262580 27325 70638505
Haematemesis 30.11 9.75 87 262527 48710 70617120
Myoclonus 29.91 9.75 32 262582 26323 70639507
Off label use 29.84 9.75 2358 260256 740702 69925128
Scoliosis 29.80 9.75 71 262543 6440 70659390
Disseminated intravascular coagulation 29.76 9.75 49 262565 33549 70632281
Hypothermia 29.49 9.75 20 262594 20574 70645256
Hyperglycaemia 29.46 9.75 131 262483 64541 70601289
Delirium 29.45 9.75 159 262455 74455 70591375
Purpura 29.21 9.75 15 262599 17960 70647870
Sputum discoloured 28.66 9.75 142 262472 18709 70647121
Aplastic anaemia 28.61 9.75 13 262601 16703 70649127
Tubulointerstitial nephritis 28.59 9.75 49 262565 33027 70632803
Muscle spasms 28.59 9.75 760 261854 153286 70512544
Hepatitis cholestatic 28.51 9.75 6 262608 12644 70653186
Creatinine renal clearance decreased 28.48 9.75 14 262600 17186 70648644
Epstein-Barr virus infection 28.27 9.75 7 262607 13191 70652639
Febrile neutropenia 28.14 9.75 560 262054 203758 70462072
Upper respiratory tract infection 28.13 9.75 431 262183 78843 70586987
Musculoskeletal pain 27.92 9.75 480 262134 89847 70575983
Bone cyst 27.69 9.75 43 262571 2831 70662999
Chronic obstructive pulmonary disease 27.51 9.75 422 262192 77219 70588611
Fluid retention 27.47 9.75 357 262257 63028 70602802
Thrombotic microangiopathy 27.39 9.75 16 262598 17832 70647998
Hepatocellular carcinoma 27.20 9.75 3 262611 10205 70655625
Sedation complication 27.05 9.75 8 262606 13402 70652428
Sinus disorder 26.85 9.75 140 262474 18819 70647011
Dry eye 26.78 9.75 208 262406 32074 70633756
Pathogen resistance 26.64 9.75 8 262606 13271 70652559
Glossodynia 26.52 9.75 459 262155 86028 70579802
Ischaemic stroke 26.33 9.75 46 262568 30774 70635056
Peritonitis 26.24 9.75 35 262579 26124 70639706
Wrong technique in product usage process 26.23 9.75 148 262466 68550 70597280
Cestode infection 26.22 9.75 15 262599 263 70665567
Suicide attempt 25.86 9.75 180 262434 79330 70586500
Acute respiratory distress syndrome 25.86 9.75 73 262541 41181 70624649
Alanine aminotransferase increased 25.86 9.75 387 262227 147093 70518737
Myelodysplastic syndrome 25.86 9.75 44 262570 29741 70636089
Schizophrenia 25.78 9.75 15 262599 16753 70649077
Hypomagnesaemia 25.65 9.75 72 262542 40692 70625138
Transplant rejection 25.55 9.75 18 262596 18153 70647677
Liver disorder 25.53 9.75 129 262485 61439 70604391
Polyneuropathy 25.44 9.75 25 262589 21390 70644440
Ejection fraction decreased 25.30 9.75 47 262567 30715 70635115
Stevens-Johnson syndrome 25.22 9.75 60 262554 35847 70629983
Infusion site extravasation 25.19 9.75 76 262538 7932 70657898
Acute graft versus host disease 25.00 9.75 3 262611 9559 70656271
Product use in unapproved indication 24.99 9.75 581 262033 206897 70458933
Neuroleptic malignant syndrome 24.88 9.75 36 262578 25971 70639859
Accidental exposure to product 24.76 9.75 41 262573 28010 70637820
Aspergillus infection 24.73 9.75 18 262596 17850 70647980
Dystonia 24.59 9.75 22 262592 19684 70646146
Acute coronary syndrome 24.36 9.75 23 262591 20056 70645774
Hyperhidrosis 24.36 9.75 649 261965 130937 70534893
Stress 24.30 9.75 370 262244 67596 70598234
Lupus vasculitis 24.29 9.75 18 262596 498 70665332
Haematuria 24.25 9.75 137 262477 63436 70602394
Drug dependence 24.17 9.75 65 262549 37256 70628574
Musculoskeletal stiffness 24.07 9.75 717 261897 147043 70518787
Aggression 24.01 9.75 95 262519 48351 70617479
Rheumatoid nodule 23.85 9.75 13 262601 15054 70650776
Hepatic encephalopathy 23.85 9.75 28 262586 22090 70643740
Suicidal ideation 23.41 9.75 156 262458 69440 70596390
Osteosclerosis 23.38 9.75 46 262568 3659 70662171
Serotonin syndrome 23.22 9.75 79 262535 42035 70623795
Proteinuria 23.18 9.75 46 262568 29328 70636502
Hypoaesthesia 23.18 9.75 739 261875 153000 70512830
Hypertransaminasaemia 22.91 9.75 3 262611 8940 70656890
Agitation 22.84 9.75 228 262386 93147 70572683
Spinal meningioma benign 22.77 9.75 10 262604 96 70665734
Pemphigus 22.75 9.75 433 262181 82603 70583227
Synovitis 22.68 9.75 633 261981 128595 70537235
Neuralgia 22.46 9.75 182 262432 28421 70637409
Weight fluctuation 22.38 9.75 82 262532 9459 70656371
Tenosynovitis 22.21 9.75 12 262602 13964 70651866
Progressive multifocal leukoencephalopathy 22.17 9.75 23 262591 19191 70646639
Oesophageal carcinoma 22.04 9.75 4 262610 9362 70656468
Blood urine present 21.54 9.75 134 262480 19219 70646611
Acute myeloid leukaemia 21.49 9.75 52 262562 30888 70634942
Cardiogenic shock 21.49 9.75 66 262548 36241 70629589
Drug tolerance decreased 21.48 9.75 5 262609 9828 70656002
Bronchitis 21.34 9.75 577 262037 116666 70549164
Respiratory depression 21.27 9.75 37 262577 24794 70641036
Blood creatinine increased 21.20 9.75 387 262227 142614 70523216
Infusion site pain 21.19 9.75 92 262522 11472 70654358
Red blood cells urine positive 21.18 9.75 51 262563 4658 70661172
White blood cells urine positive 21.12 9.75 57 262557 5583 70660247
Peripheral venous disease 21.12 9.75 87 262527 10600 70655230
Hallucination, auditory 21.08 9.75 22 262592 18306 70647524
Urinary sediment present 21.07 9.75 34 262580 2313 70663517
Systemic lupus erythematosus 21.03 9.75 510 262104 101392 70564438
Haemophagocytic lymphohistiocytosis 20.96 9.75 25 262589 19587 70646243
Ventricular fibrillation 20.93 9.75 43 262571 27068 70638762
Influenza like illness 20.85 9.75 349 262265 64982 70600848
Exposure during pregnancy 20.70 9.75 216 262398 87501 70578329
Upper-airway cough syndrome 20.65 9.75 81 262533 9650 70656180
Limb mass 20.49 9.75 41 262573 3301 70662529
Sinus congestion 20.42 9.75 122 262492 17251 70648579
Akathisia 20.36 9.75 10 262604 12283 70653547
Aspartate aminotransferase increased 20.31 9.75 339 262275 126639 70539191
Cytomegalovirus viraemia 20.14 9.75 9 262605 11676 70654154
Hepatitis B 20.13 9.75 3 262611 8111 70657719
Injection site pain 19.81 9.75 311 262303 117308 70548522
Cholangitis 19.74 9.75 9 262605 11540 70654290
BK virus infection 19.72 9.75 3 262611 7986 70657844
Pemphigoid 19.57 9.75 14 262600 14008 70651822
Injection site erythema 19.57 9.75 174 262440 72750 70593080
Dry mouth 19.51 9.75 368 262246 70089 70595741
Bladder cancer 19.49 9.75 21 262593 17221 70648609
Nausea 19.41 9.75 3509 259105 848579 69817251
Asphyxia 19.40 9.75 7 262607 10335 70655495
Product substitution issue 19.36 9.75 24 262590 18489 70647341
Dysarthria 19.33 9.75 143 262471 62170 70603660
Ear pruritus 19.23 9.75 38 262576 3032 70662798
Feeling abnormal 19.13 9.75 675 261939 141644 70524186
Arteriovenous fistula occlusion 19.05 9.75 16 262598 533 70665297
Hyperthyroidism 19.03 9.75 28 262586 20063 70645767
Concussion 19.02 9.75 72 262542 8437 70657393
Enteritis 19.00 9.75 12 262602 12819 70653011
Premenstrual syndrome 18.99 9.75 16 262598 535 70665295
Hepatitis 18.91 9.75 108 262506 49872 70615958
Colitis microscopic 18.86 9.75 5 262609 9000 70656830
Cognitive disorder 18.85 9.75 140 262474 60816 70605014
Diabetic ketoacidosis 18.85 9.75 57 262557 31455 70634375
Intentional overdose 18.77 9.75 254 262360 98181 70567649
Acute myocardial infarction 18.65 9.75 176 262438 72711 70593119
Nephrotic syndrome 18.64 9.75 8 262606 10632 70655198
Dyspepsia 18.44 9.75 446 262168 88631 70577199
Magnesium deficiency 18.35 9.75 16 262598 561 70665269
Arrhythmia 18.31 9.75 127 262487 56016 70609814
Drug intolerance 18.27 9.75 1016 261598 224671 70441159
Platelet count decreased 18.26 9.75 511 262103 177711 70488119
Death 18.25 9.75 1633 260981 508428 70157402
Sedation 18.21 9.75 100 262514 46631 70619199
Finger deformity 18.15 9.75 57 262557 6079 70659751
Hypertensive crisis 18.10 9.75 27 262587 19235 70646595
Immune reconstitution inflammatory syndrome 18.09 9.75 13 262601 12977 70652853
Hyperthermia 18.09 9.75 21 262593 16650 70649180
Left ventricular dysfunction 18.04 9.75 24 262590 17933 70647897
Congestive cardiomyopathy 17.93 9.75 9 262605 10917 70654913
Face oedema 17.88 9.75 43 262571 25596 70640234
Urinary tract infection 17.87 9.75 1108 261506 247661 70418169
Lip pruritus 17.83 9.75 18 262596 762 70665068
Electrocardiogram QRS complex prolonged 17.79 9.75 7 262607 9799 70656031
Shock 17.74 9.75 83 262531 40342 70625488
Corneal epithelium defect 17.65 9.75 17 262597 679 70665151
Jaundice cholestatic 17.60 9.75 6 262608 9178 70656652
Cystitis haemorrhagic 17.57 9.75 5 262609 8588 70657242
Product tampering 17.52 9.75 11 262603 230 70665600
Body height decreased 17.51 9.75 66 262548 7717 70658113
Failure to thrive 17.49 9.75 83 262531 10746 70655084
Dermatitis bullous 17.46 9.75 13 262601 12744 70653086
Throat tightness 17.42 9.75 155 262459 24867 70640963
Sneezing 17.41 9.75 115 262499 16836 70648994
Anterior chamber cell 17.32 9.75 19 262595 886 70664944
Immunosuppressant drug level increased 17.32 9.75 4 262610 7903 70657927
Encephalitis 17.15 9.75 15 262599 13570 70652260
Skin toxicity 17.10 9.75 3 262611 7195 70658635
Sternal fracture 17.08 9.75 31 262583 2320 70663510
Culture urine positive 17.07 9.75 44 262570 4193 70661637
Therapeutic response shortened 16.96 9.75 93 262521 12745 70653085
Pharyngeal paraesthesia 16.94 9.75 30 262584 2202 70663628
Hypoalbuminaemia 16.83 9.75 28 262586 19094 70646736
Intentional product use issue 16.69 9.75 572 262042 119570 70546260
Hip fracture 16.66 9.75 169 262445 28094 70637736
Cataract 16.58 9.75 294 262320 55351 70610479
Tardive dyskinesia 16.56 9.75 8 262606 9921 70655909
Body temperature fluctuation 16.50 9.75 39 262575 3520 70662310
Ventricular tachycardia 16.45 9.75 74 262540 36349 70629481
Pulmonary function test decreased 16.42 9.75 59 262555 6742 70659088
Neurotoxicity 16.41 9.75 56 262558 29770 70636060
Gastric disorder 16.30 9.75 192 262422 33130 70632700
Potentiating drug interaction 16.23 9.75 5 262609 8159 70657671
Dental caries 16.17 9.75 83 262531 11088 70654742
Wheezing 16.16 9.75 460 262154 93710 70572120
Hyperammonaemia 16.12 9.75 9 262605 10284 70655546
Disturbance in attention 16.06 9.75 93 262521 42801 70623029
Hypercalcaemia 16.05 9.75 69 262545 34316 70631514
Haematoma 16.05 9.75 109 262505 48309 70617521
Hypersensitivity vasculitis 15.87 9.75 3 262611 6819 70659011
Hepatitis acute 15.79 9.75 17 262597 13945 70651885
Second primary malignancy 15.78 9.75 15 262599 13036 70652794
Mucormycosis 15.77 9.75 5 262609 8009 70657821
Bacterial test 15.75 9.75 21 262593 1202 70664628
Chronic graft versus host disease 15.70 9.75 3 262611 6767 70659063
Nervous system disorder 15.68 9.75 42 262572 24104 70641726
Drug withdrawal syndrome 15.67 9.75 65 262549 32650 70633180
Menstruation delayed 15.67 9.75 21 262593 1208 70664622
Intestinal ischaemia 15.62 9.75 13 262601 12051 70653779
Post-traumatic neck syndrome 15.60 9.75 27 262587 1946 70663884
Tumour lysis syndrome 15.56 9.75 35 262579 21325 70644505
Acute pulmonary oedema 15.54 9.75 16 262598 13396 70652434
Infusion site erythema 15.41 9.75 62 262552 7473 70658357
Constipation 15.39 9.75 1109 261505 251329 70414501
Leukoencephalopathy 15.37 9.75 4 262610 7290 70658540
Respiratory tract congestion 15.34 9.75 115 262499 17538 70648292
Gastric cancer 15.27 9.75 7 262607 8948 70656882
Pulmonary tuberculosis 15.25 9.75 5 262609 7840 70657990
Oligomenorrhoea 15.23 9.75 15 262599 616 70665214
Cutaneous vasculitis 15.19 9.75 4 262610 7234 70658596
Injury 15.15 9.75 332 262282 64913 70600917
Bradyphrenia 15.15 9.75 9 262605 9937 70655893
Rib fracture 15.13 9.75 152 262462 25204 70640626
Deep vein thrombosis postoperative 15.09 9.75 38 262576 3569 70662261
Lichen sclerosus 15.04 9.75 18 262596 923 70664907
Urogenital prolapse 15.04 9.75 5 262609 20 70665810
Poor venous access 15.03 9.75 101 262513 14870 70650960
Large intestine perforation 15.00 9.75 16 262598 13179 70652651
Pulmonary alveolar haemorrhage 14.94 9.75 10 262604 10359 70655471
Nerve compression 14.94 9.75 65 262549 8113 70657717
Stress cardiomyopathy 14.91 9.75 9 262605 9853 70655977
Polymenorrhoea 14.91 9.75 18 262596 932 70664898
Unintentional medical device removal 14.83 9.75 4 262610 7120 70658710
Liver function test abnormal 14.66 9.75 150 262464 60996 70604834
Scratch 14.49 9.75 59 262555 7151 70658679
Eczema 14.45 9.75 70 262544 33711 70632119
Noninfective gingivitis 14.44 9.75 23 262591 1548 70664282
Catatonia 14.44 9.75 6 262608 8127 70657703
International normalised ratio increased 14.43 9.75 211 262403 80515 70585315
Body temperature decreased 14.38 9.75 166 262448 28506 70637324
Emotional distress 14.29 9.75 205 262409 36983 70628847
Diabetes mellitus 14.18 9.75 184 262430 71640 70594190
Diffuse large B-cell lymphoma 14.17 9.75 17 262597 13285 70652545
Poor quality sleep 14.14 9.75 126 262488 20223 70645607
Muscle rigidity 14.05 9.75 30 262584 18620 70647210
Tooth disorder 14.04 9.75 143 262471 23795 70642035
Tuberculosis 13.77 9.75 21 262593 14827 70651003
Skin ulcer 13.76 9.75 113 262501 48032 70617798
Endometrial disorder 13.75 9.75 13 262601 507 70665323
Metastases to lung 13.72 9.75 25 262589 16459 70649371
Band sensation 13.72 9.75 15 262599 697 70665133
Alopecia 13.68 9.75 881 261733 197609 70468221
Type IIa hyperlipidaemia 13.66 9.75 11 262603 345 70665485
Hallucination, visual 13.62 9.75 59 262555 29278 70636552
Renal tubular disorder 13.56 9.75 3 262611 6107 70659723
Urine ketone body present 13.52 9.75 35 262579 3344 70662486
Device use error 13.50 9.75 4 262610 6692 70659138
Specific gravity urine increased 13.45 9.75 12 262602 434 70665396
Hyperbilirubinaemia 13.37 9.75 41 262573 22527 70643303
Arteriospasm coronary 13.29 9.75 3 262611 6021 70659809
Ileus paralytic 13.24 9.75 8 262606 8753 70657077
Disease progression 13.18 9.75 461 262153 156211 70509619
Loss of consciousness 13.15 9.75 458 262156 155258 70510572
Transaminases increased 13.14 9.75 111 262503 46907 70618923
Abortion spontaneous 13.07 9.75 52 262562 26427 70639403
Haemodialysis 13.02 9.75 28 262586 17338 70648492
Hepatic cirrhosis 12.96 9.75 64 262550 30667 70635163
Myocardial ischaemia 12.94 9.75 46 262568 24154 70641676
Encephalopathy 12.91 9.75 156 262458 61505 70604325
Soft tissue injury 12.89 9.75 23 262591 1699 70664131
Ligament sprain 12.80 9.75 82 262532 11881 70653949
Hyperuricaemia 12.80 9.75 13 262601 10953 70654877
Hypothyroidism 12.80 9.75 108 262506 45647 70620183
Respiratory failure 12.75 9.75 503 262111 168232 70497598
Necrosis 12.74 9.75 8 262606 8573 70657257
Mania 12.62 9.75 28 262586 17146 70648684
Chest pain 12.56 9.75 1087 261527 250173 70415657
Toxic encephalopathy 12.53 9.75 12 262602 10394 70655436
Urinary retention 12.52 9.75 129 262485 52391 70613439
Urethral meatus stenosis 12.51 9.75 5 262609 37 70665793
Blue toe syndrome 12.50 9.75 13 262601 570 70665260
Creatinine urine decreased 12.49 9.75 9 262605 238 70665592
Gait disturbance 12.47 9.75 820 261794 184286 70481544
Ulcer 12.44 9.75 51 262563 25703 70640127
Staphylococcal sepsis 12.44 9.75 19 262595 13408 70652422
Limb injury 12.43 9.75 148 262466 25604 70640226
Hot flush 12.38 9.75 255 262359 49329 70616501
Nephrolithiasis 12.36 9.75 245 262369 47078 70618752
Paraesthesia 12.32 9.75 658 261956 144879 70520951
Bone pain 12.25 9.75 260 262354 50562 70615268
Sepsis 12.23 9.75 761 261853 243784 70422046
Gynaecomastia 12.16 9.75 5 262609 6818 70659012
Hepatosplenomegaly 12.16 9.75 3 262611 5667 70660163
SARS-CoV-2 test positive 12.15 9.75 64 262550 8637 70657193
Muscle strain 12.12 9.75 64 262550 8646 70657184
Foreign body 12.11 9.75 29 262585 2639 70663191
Foetal death 12.09 9.75 4 262610 6235 70659595
Urine analysis abnormal 12.08 9.75 50 262564 6104 70659726
Blood bilirubin increased 11.99 9.75 153 262461 59748 70606082
Myocarditis 11.97 9.75 33 262581 18760 70647070
Exposure to toxic agent 11.95 9.75 4 262610 6190 70659640
Nitrite urine present 11.95 9.75 18 262596 1154 70664676
Dry throat 11.93 9.75 53 262561 6675 70659155
Hospice care 11.91 9.75 61 262553 8144 70657686
Oral pain 11.88 9.75 162 262452 28904 70636926
Adenovirus infection 11.87 9.75 7 262607 7761 70658069
Subarachnoid haemorrhage 11.87 9.75 35 262579 19469 70646361
Dry skin 11.86 9.75 281 262333 55650 70610180
Dysgeusia 11.85 9.75 253 262361 49249 70616581
Pancreatitis 11.84 9.75 162 262452 62506 70603324
Maternal exposure before pregnancy 11.80 9.75 36 262578 3780 70662050
Disease recurrence 11.80 9.75 86 262528 37517 70628313
Full blood count decreased 11.78 9.75 138 262476 23780 70642050
Toothache 11.74 9.75 112 262502 18318 70647512
Chest X-ray abnormal 11.72 9.75 55 262559 7089 70658741
Partial seizures 11.71 9.75 8 262606 8197 70657633
Blood lactate dehydrogenase increased 11.68 9.75 79 262535 35048 70630782
Hypertriglyceridaemia 11.65 9.75 16 262598 11795 70654035
Drug use disorder 11.56 9.75 8 262606 8143 70657687
Nephrogenic systemic fibrosis 11.52 9.75 4 262610 6048 70659782
Joint range of motion decreased 11.45 9.75 147 262467 25879 70639951
Metastases to liver 11.44 9.75 53 262561 25825 70640005
Head discomfort 11.41 9.75 85 262529 12938 70652892
Multiple sclerosis relapse 11.33 9.75 223 262391 42794 70623036
Palpitations 11.31 9.75 510 262104 110243 70555587
Salivary hypersecretion 11.31 9.75 19 262595 12906 70652924
Sudden death 11.29 9.75 40 262574 21024 70644806
Therapy partial responder 11.23 9.75 18 262596 12456 70653374
Post concussion syndrome 11.21 9.75 12 262602 544 70665286
Gastrointestinal haemorrhage 11.18 9.75 406 262208 137002 70528828
Mean cell haemoglobin concentration decreased 11.13 9.75 37 262577 4066 70661764
Feeling cold 11.07 9.75 144 262470 25426 70640404
Biopsy kidney 11.04 9.75 7 262607 149 70665681
Hangover 11.01 9.75 23 262591 1910 70663920
Cytomegalovirus chorioretinitis 10.98 9.75 3 262611 5295 70660535
Anhedonia 10.92 9.75 90 262524 14123 70651707
Fibromyalgia 10.92 9.75 243 262371 47631 70618199
Cushingoid 10.91 9.75 9 262605 8379 70657451
Red blood cell sedimentation rate increased 10.90 9.75 91 262523 38551 70627279
Pharyngeal disorder 10.89 9.75 23 262591 1924 70663906
Deformity 10.89 9.75 60 262554 8237 70657593
Human papilloma virus test positive 10.89 9.75 11 262603 466 70665364
Treatment noncompliance 10.86 9.75 115 262499 46459 70619371
Oedema peripheral 10.85 9.75 713 261901 227378 70438452
Full blood count abnormal 10.82 9.75 181 262433 33697 70632133
Genital haemorrhage 10.80 9.75 4 262610 5811 70660019
Cerebral haematoma 10.79 9.75 7 262607 7371 70658459
Pulse abnormal 10.79 9.75 29 262585 2834 70662996
Extrapyramidal disorder 10.72 9.75 40 262574 20710 70645120
Rash erythematous 10.72 9.75 259 262355 51459 70614371
Peripheral ischaemia 10.66 9.75 10 262604 8748 70657082
Punctate keratitis 10.64 9.75 15 262599 905 70664925
Device dislocation 10.61 9.75 45 262569 22462 70643368
Abnormal behaviour 10.60 9.75 80 262534 34629 70631201
Vein collapse 10.56 9.75 15 262599 912 70664918
White coat hypertension 10.51 9.75 13 262601 690 70665140
Tongue oedema 10.51 9.75 5 262609 6254 70659576
Eye infection viral 10.50 9.75 6 262608 105 70665725
Infusion site pruritus 10.45 9.75 31 262583 3206 70662624
Asthma 10.40 9.75 547 262067 120246 70545584
Confusional state 10.39 9.75 1204 261410 283194 70382636
Pneumonia aspiration 10.38 9.75 165 262449 62124 70603706
Hiatus hernia strangulated 10.38 9.75 7 262607 166 70665664
Infusion site swelling 10.37 9.75 48 262566 6150 70659680
Hypovolaemic shock 10.37 9.75 15 262599 10822 70655008
Dermatitis allergic 10.35 9.75 29 262585 16402 70649428
Duodenal ulcer haemorrhage 10.34 9.75 6 262608 6712 70659118
Pulmonary haemorrhage 10.29 9.75 22 262592 13651 70652179
Lymphocyte count decreased 10.25 9.75 222 262392 43317 70622513
Myopathy 10.20 9.75 35 262579 18577 70647253
Cardiac failure acute 10.20 9.75 32 262582 17455 70648375
Joint stiffness 10.18 9.75 185 262429 34991 70630839
Rash pustular 10.13 9.75 14 262600 10294 70655536
Injection site reaction 10.10 9.75 127 262487 49725 70616105
Flatulence 10.08 9.75 198 262416 37983 70627847
Inappropriate schedule of product administration 10.07 9.75 491 262123 107064 70558766
Erectile dysfunction 10.06 9.75 22 262592 13540 70652290
Exostosis 10.06 9.75 89 262525 14256 70651574
Hepatitis fulminant 9.96 9.75 6 262608 6575 70659255
COVID-19 9.95 9.75 483 262131 105274 70560556
Klebsiella infection 9.94 9.75 24 262590 14268 70651562
Sinus headache 9.93 9.75 38 262576 4475 70661355
Renal tubular necrosis 9.92 9.75 48 262566 23123 70642707
Mite allergy 9.88 9.75 14 262600 849 70664981
Withdrawal syndrome 9.86 9.75 53 262561 24851 70640979
Thyroid stimulating immunoglobulin 9.86 9.75 5 262609 68 70665762
Enterocolitis 9.85 9.75 21 262593 13045 70652785
Euglycaemic diabetic ketoacidosis 9.78 9.75 5 262609 6002 70659828
Stupor 9.76 9.75 6 262608 6503 70659327

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R05CA03 RESPIRATORY SYSTEM
COUGH AND COLD PREPARATIONS
EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH SUPPRESSANTS
Expectorants
FDA PE N0000008867 Decreased Respiratory Secretion Viscosity
FDA PE N0000009560 Increased Respiratory Secretions
MeSH PA D005100 Expectorants
MeSH PA D019141 Respiratory System Agents
FDA EPC N0000193956 Expectorant

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Sinus headache indication 4969004
Cough indication 49727002
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Rhinitis indication 70076002 DOID:4483
Common cold indication 82272006 DOID:10459
Headache disorder indication 230461009
Influenza-like symptoms indication 315642008
Fever indication 386661006
Asthma off-label use 195967001 DOID:2841
Asthma-chronic obstructive pulmonary disease overlap syndrome off-label use 10692761000119107
Chronic Obstructive Pulmonary Disease with Bronchospasms off-label use
COPD Associated with Chronic Bronchitis off-label use
Metabolic alkalosis contraindication 1388004
Brain damage contraindication 2470005
Anuria contraindication 2472002 DOID:2983
Necrotizing enterocolitis in fetus OR newborn contraindication 2707005
Ocular hypertension contraindication 4210003 DOID:9282
Gastritis contraindication 4556007 DOID:4029
Hypocalcemia contraindication 5291005
Tachyarrhythmia contraindication 6285003
Suicidal thoughts contraindication 6471006
Dependent drug abuse contraindication 6525002
Urinary tract obstruction contraindication 7163005 DOID:5200
Alcoholism contraindication 7200002
Alcohol withdrawal delirium contraindication 8635005
Hyperammonemia contraindication 9360008
Peptic ulcer contraindication 13200003 DOID:750
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Asthenia contraindication 13791008
Hepatic encephalopathy contraindication 13920009 DOID:13413
Hyperkalemia contraindication 14140009
Severe chronic ulcerative colitis contraindication 14311001
Constipation contraindication 14760008 DOID:2089
Chronic disease of respiratory system contraindication 17097001
Mood swings contraindication 18963009
Pulmonary edema contraindication 19242006 DOID:11396
Cirrhosis of liver contraindication 19943007 DOID:5082
Myocardial infarction contraindication 22298006 DOID:5844
Glaucoma contraindication 23986001 DOID:1686
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Ventricular tachycardia contraindication 25569003
Alcohol intoxication contraindication 25702006
Shock contraindication 27942005
Toxic megacolon contraindication 28536002 DOID:1770
Atony of colon contraindication 29479008
Hypercapnia contraindication 29596007
Dehydration contraindication 34095006
Hyperthyroidism contraindication 34486009 DOID:7998
Depressive disorder contraindication 35489007
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Hypernatremia contraindication 39355002
Disorder of gallbladder contraindication 39621005 DOID:0060262
Hypothyroidism contraindication 40930008 DOID:1459
Complete trisomy 21 syndrome contraindication 41040004 DOID:14250
Alcoholic liver damage contraindication 41309000
Third trimester pregnancy contraindication 41587001
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Achalasia of esophagus contraindication 45564002 DOID:9164
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Acidosis contraindication 51387008
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Paralytic ileus contraindication 55525008 DOID:8442
Heart disease contraindication 56265001 DOID:114
Peptic reflux disease contraindication 57643001
Multiple organ failure contraindication 57653000
Acute nephropathy contraindication 58574008
Metabolic acidosis contraindication 59455009
Hepatic failure contraindication 59927004
Diarrhea contraindication 62315008
Ulcerative colitis contraindication 64766004 DOID:8577
Poisoning by phenobarbital contraindication 64921004
Arterial thrombosis contraindication 65198009
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Psychotic disorder contraindication 69322001
Poisoning by acetaminophen contraindication 70273001
Agoraphobia contraindication 70691001 DOID:593
Arteriosclerotic vascular disease contraindication 72092001
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Sleep apnea contraindication 73430006 DOID:0050847
Urethral stricture contraindication 76618002
Spastic paralysis contraindication 78403003
Disturbance of salivary secretion contraindication 78948009
Decreased respiratory function contraindication 80954004
Injury of head contraindication 82271004
Chronic idiopathic constipation contraindication 82934008
Oliguria contraindication 83128009
Cor pulmonale contraindication 83291003 DOID:8515
Hiatal hernia contraindication 84089009 DOID:12642
Epilepsy contraindication 84757009 DOID:1826
Pulmonary emphysema contraindication 87433001
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Acute abdominal pain contraindication 116290004
Procedure on urinary system contraindication 118677009
Gastrointestinal obstruction contraindication 126765001
Neoplasm of brain contraindication 126952004 DOID:1319
Seizure disorder contraindication 128613002
Autonomic dysreflexia contraindication 129618003
Bleeding contraindication 131148009
Cystic fibrosis contraindication 190905008 DOID:1485
Drug-induced psychosis contraindication 191483003 DOID:1742
Obsessive-compulsive disorder contraindication 191736004 DOID:10933
Insomnia contraindication 193462001
Angina pectoris contraindication 194828000
Partial atrioventricular block contraindication 195039008
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Myocardial dysfunction contraindication 233928007
Disease of liver contraindication 235856003 DOID:409
Hyporeninemic hypoaldosteronism contraindication 236464008
Bladder outflow obstruction contraindication 236645006
Morbid obesity contraindication 238136002 DOID:11981
Sepsis syndrome contraindication 238150007
Rhabdomyolysis contraindication 240131006
Pyloric obstruction contraindication 244815007
Benign prostatic hyperplasia contraindication 266569009
Dyspnea contraindication 267036007
Retention of urine contraindication 267064002
Anemia contraindication 271737000 DOID:2355
Continuous fever contraindication 271751000
Drowsy contraindication 271782001
Peripheral edema contraindication 271809000
Exacerbation of asthma contraindication 281239006
Pregnancy, function contraindication 289908002
Lesion of brain contraindication 301766008
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Familial hyperkalemic periodic paralysis contraindication 304737009 DOID:14451
Panic disorder contraindication 371631005 DOID:594
Coma contraindication 371632003
Primary adrenocortical insufficiency contraindication 373662000
Smoking cessation assistance contraindication 384742004
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Operation on gastrointestinal tract contraindication 386621005
Hypoxia contraindication 389086002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Pseudomembranous enterocolitis contraindication 397683000
Gastric ulcer contraindication 397825006 DOID:10808
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Chronic myocardial ischemia contraindication 413844008 DOID:3393
Disorder of coronary artery contraindication 414024009
Myocardial ischemia contraindication 414795007 DOID:3393
Traumatic injury contraindication 417746004
Myocardial infarction in recovery phase contraindication 418044006
Central nervous system depression contraindication 418072004
Porphyria contraindication 418470004
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant contraindication 422681000
Fever greater than 100.4 Fahrenheit contraindication 426000000
Dysfunction of sphincter of Oddi contraindication 430887001
Hypertensive urgency contraindication 443482000
Azotemia contraindication 445009001
Smokes tobacco daily contraindication 449868002
Severe dehydration contraindication 450316000
Acute exacerbation of asthma contraindication 708038006
Severe Hypoxemia contraindication
Theophylline Toxicity contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

ProductApplicantIngredients
Gecolate Summit Hill Laboratories 1
Gecolate, Glycodex Injection Summit Hill Laboratories 1
Guailaxin Zoetis Inc. 1
Guaifenesin Injection Elanco US Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
200MG/5ML;2.5MG/5ML OBREDON SOVEREIGN PHARMS N205474 Nov. 14, 2014 DISCN SOLUTION ORAL 10105324 Nov. 13, 2035 A METHOD OF INCREASING THE BIOAVAILABILITY OF GUAIFENESIN IN A SOLUTION CONTAINING 54% TO 66% BY WEIGHT OF PROPYLENE GLYCOL AND GLYCEROL, WHEREIN THE METHOD INCREASES THE CMAX BY AT LEAST 1.5 AND/OR INCREASES THE AUC (0-INF) BY AT LEAST 1.4
200MG/5ML;2.5MG/5ML OBREDON SOVEREIGN PHARMS N205474 Nov. 14, 2014 DISCN SOLUTION ORAL 9549907 Nov. 13, 2035 A METHOD OF INCREASING THE BIOAVAILABILITY OF GUAIFENESIN IN A SOLUTION CONTAINING 54% TO 66% BY WEIGHT OF PROPYLENE GLYCOL AND GLYCEROL, WHEREIN THE METHOD INCREASES THE CMAX BY AT LEAST 1.5 AND/OR INCREASES THE AUC (0-INF) BY AT LEAST 1.4
200MG/5ML;2.5MG/5ML OBREDON SOVEREIGN PHARMS N205474 Nov. 14, 2014 DISCN SOLUTION ORAL 9808431 Nov. 13, 2035 A METHOD OF INCREASING THE BIOAVAILABILITY OF GUAIFENESIN IN A SOLUTION CONTAINING 54% TO 66% BY WEIGHT OF PROPYLENE GLYCOL AND GLYCEROL, WHEREIN THE METHOD INCREASES THE CMAX BY AT LEAST 1.5 AND/OR INCREASES THE AUC (0-INF) BY AT LEAST 1.4

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018147 VUID
N0000146484 NUI
D00337 KEGG_DRUG
4018147 VANDF
C0018305 UMLSCUI
CHEBI:5551 CHEBI
CHEMBL980 ChEMBL_ID
DB00874 DRUGBANK_ID
D006140 MESH_DESCRIPTOR_UI
3516 PUBCHEM_CID
968 INN_ID
7617 IUPHAR_LIGAND_ID
495W7451VQ UNII
5032 RXNORM
2461 MMSL
4805 MMSL
d00797 MMSL
000724 NDDF
386184000 SNOMEDCT_US
87174009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Robitussin Elderberry Maximum Strength Cough plus Chest Congestion DM HUMAN OTC DRUG LABEL 2 0031-2097 SOLUTION 400 mg ORAL OTC monograph final 15 sections
Childrens Robitussin Elderberry Cough and Chest Congestion DM HUMAN OTC DRUG LABEL 2 0031-2098 SOLUTION 400 mg ORAL OTC monograph final 15 sections
Robitussin CF HUMAN OTC DRUG LABEL 3 0031-8678 LIQUID 100 mg ORAL Export only 15 sections
Childrens Robitussin Cough and Chest Congestion DM HUMAN OTC DRUG LABEL 2 0031-8702 LIQUID 200 mg ORAL OTC MONOGRAPH FINAL 15 sections
Childrens Robitussin Cough and Chest Congestion DM HUMAN OTC DRUG LABEL 2 0031-8715 LIQUID 100 mg ORAL OTC monograph final 15 sections
Childrens Robitussin Cough and Cold CF HUMAN OTC DRUG LABEL 3 0031-8716 LIQUID 50 mg ORAL OTC monograph final 17 sections
Childrens Robitussin Cough and Cold CF HUMAN OTC DRUG LABEL 3 0031-8716 LIQUID 50 mg ORAL OTC monograph final 17 sections
Robitussin Maximum Strength Cough Plus Chest Congestion DM HUMAN OTC DRUG LABEL 2 0031-8719 CAPSULE, LIQUID FILLED 200 mg ORAL OTC MONOGRAPH FINAL 15 sections
Robitussin Mucus Plus Chest Congestion HUMAN OTC DRUG LABEL 1 0031-8724 LIQUID 200 mg ORAL OTC MONOGRAPH FINAL 14 sections
ROBITUSSIN MAXIMUM STRENGTH COUGH PLUS CHEST CONGESTION DM HUMAN OTC DRUG LABEL 2 0031-8739 SOLUTION 400 mg ORAL OTC monograph final 15 sections
Robitussin Peak Cold Multi-Symptom Cold HUMAN OTC DRUG LABEL 3 0031-8742 LIQUID 100 mg ORAL OTC MONOGRAPH FINAL 17 sections
ROBITUSSIN CHEST CONGESTION HUMAN OTC DRUG LABEL 1 0031-8748 LIQUID 100 mg ORAL EXPORT ONLY 1 sections
Robitussin Severe Multi-Symptom Cough Cold Flu HUMAN OTC DRUG LABEL 4 0031-8751 LIQUID 400 mg ORAL OTC monograph final 17 sections
Robitussin Honey Maximum Strength Cough and Chest Congestion DM HUMAN OTC DRUG LABEL 2 0031-8756 SOLUTION 400 mg ORAL OTC monograph final 15 sections
ROBITUSSIN COUGH PLUS CHEST CONGESTION DM HUMAN OTC DRUG LABEL 2 0031-8757 SOLUTION 200 mg ORAL OTC monograph final 15 sections
Robitussin Sugar-Free Dye-Free Cough Plus Chest Congestion DM HUMAN OTC DRUG LABEL 2 0031-8759 SOLUTION 200 mg ORAL OTC monograph final 15 sections
Childrens Robitussin Honey Cough and Chest Congestion DM HUMAN OTC DRUG LABEL 2 0031-8760 SOLUTION 100 mg ORAL OTC MONOGRAPH FINAL 15 sections
Robitussin Maximum Strength 12 Hour Cough and Mucus Relief HUMAN OTC DRUG LABEL 2 0031-8765 TABLET, EXTENDED RELEASE 1200 mg ORAL ANDA 16 sections
Robitussin Direct Chest Congestion HUMAN OTC DRUG LABEL 1 0031-9303 TABLET, COATED 400 mg ORAL OTC monograph final 14 sections
TherafluCough Relief HUMAN OTC DRUG LABEL 2 0067-6089 POWDER, FOR SOLUTION 400 mg ORAL OTC monograph final 15 sections
Theraflu ExpressMax Severe Cold and Flu Syrup HUMAN OTC DRUG LABEL 4 0067-8132 SYRUP 400 mg ORAL OTC monograph final 16 sections
Theraflu ExpressMax Severe Cold and Flu Caplets HUMAN OTC DRUG LABEL 4 0067-8145 TABLET, COATED 200 mg ORAL OTC monograph final 16 sections
good sense tussinmucus and chest congestion HUMAN OTC DRUG LABEL 1 0113-0061 SOLUTION 200 mg ORAL OTC monograph final 13 sections
Good Sense Mucus ReliefCold and Sinus HUMAN OTC DRUG LABEL 3 0113-0145 TABLET, COATED 200 mg ORAL OTC monograph final 16 sections
good sense tussincf max HUMAN OTC DRUG LABEL 3 0113-0296 SOLUTION 400 mg ORAL OTC monograph final 15 sections
Good Sense Mucus ER HUMAN OTC DRUG LABEL 1 0113-0325 TABLET, EXTENDED RELEASE 1200 mg ORAL ANDA 14 sections
good sense tussin dm HUMAN OTC DRUG LABEL 2 0113-0359 SOLUTION 200 mg ORAL OTC monograph final 14 sections
good sense tussin dm HUMAN OTC DRUG LABEL 2 0113-0359 SOLUTION 200 mg ORAL OTC monograph final 14 sections
Good Sense Mucus Reliefcold flu and sore throat HUMAN OTC DRUG LABEL 4 0113-0381 TABLET, FILM COATED 200 mg ORAL OTC monograph final 16 sections
Good Sense Childrens Mucus Relief Cough HUMAN OTC DRUG LABEL 2 0113-0419 SOLUTION 100 mg ORAL OTC monograph final 13 sections