guaifenesin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1336 93-14-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • guaifenesin
  • glycerin guaiacolate
  • glycerol guaiacolate
  • guaifenesine
  • guaiphenesin
  • guaiphenesine
  • myocain
  • myocaine
  • myoscain
An expectorant that also has some muscle relaxing action. It is used in many cough preparations.
  • Molecular weight: 198.22
  • Formula: C10H14O4
  • CLOGP: 0.10
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 58.92
  • ALOGS: -1.12
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.90 g O
0.90 g P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
July 12, 2002 FDA RECKITT BENCKISER

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Irritable bowel syndrome 542.68 9.87 873 218410 50568 50335273
Folliculitis 535.56 9.87 751 218532 38474 50347367
Muscle injury 531.37 9.87 727 218556 36384 50349457
Sinusitis 495.56 9.87 1745 217538 168813 50217028
Lower respiratory tract infection 483.54 9.87 1189 218094 94012 50291829
Drug interaction 392.64 9.87 187 219096 199434 50186407
Peripheral swelling 391.04 9.87 1847 217436 204089 50181752
Sleep disorder due to general medical condition, insomnia type 365.31 9.87 558 218725 30889 50354952
Nasopharyngitis 364.52 9.87 1728 217555 191199 50194642
Ill-defined disorder 341.64 9.87 741 218542 53913 50331928
Impaired healing 328.45 9.87 847 218436 68939 50316902
Gastrointestinal disorder 308.80 9.87 1006 218277 93450 50292391
Pruritus 301.25 9.87 2181 217102 281387 50104454
Blister 285.76 9.87 917 218366 84501 50301340
Stomatitis 263.62 9.87 1001 218282 100343 50285498
Ear pain 259.41 9.87 451 218832 27832 50358009
Toxicity to various agents 259.20 9.87 324 218959 212175 50173666
Body temperature increased 250.81 9.87 471 218812 30870 50354971
Muscle spasticity 231.46 9.87 327 218956 16857 50368984
Completed suicide 222.61 9.87 149 219134 131740 50254101
Weight increased 221.14 9.87 1565 217718 200326 50185515
Infusion related reaction 188.88 9.87 1320 217963 168237 50217604
Joint swelling 184.07 9.87 1745 217538 243541 50142300
Night sweats 178.43 9.87 427 218856 33147 50352694
Fatigue 163.79 9.87 4113 215170 703488 49682353
Acute kidney injury 154.35 9.87 491 218792 227567 50158274
Respiratory disorder 152.30 9.87 384 218899 30803 50355038
Therapeutic product effect decreased 143.78 9.87 1046 218237 135004 50250837
Back pain 135.21 9.87 1503 217780 218527 50167314
Infection 134.88 9.87 1241 218042 171713 50214128
Contusion 131.72 9.87 885 218398 111298 50274543
Insomnia 128.03 9.87 1238 218045 173627 50212214
Blood pressure fluctuation 118.25 9.87 383 218900 35440 50350401
Hypersensitivity 117.59 9.87 1437 217846 213724 50172117
Urticaria 117.33 9.87 961 218322 128600 50257241
Pain 117.16 9.87 3308 215975 575595 49810246
Rheumatoid arthritis 106.03 9.87 1342 217941 201208 50184633
Blood pressure diastolic abnormal 97.43 9.87 158 219125 9203 50376638
General physical health deterioration 96.73 9.87 306 218977 142128 50243713
Headache 94.79 9.87 2867 216416 503668 49882173
Arthralgia 91.08 9.87 2516 216767 436186 49949655
Neutropenia 90.22 9.87 333 218950 147632 50238209
Thrombocytopenia 88.30 9.87 272 219011 127401 50258440
Cardiac failure 86.38 9.87 122 219161 75918 50309923
Blood pressure increased 86.08 9.87 919 218364 132213 50253628
Blood pressure systolic increased 85.43 9.87 342 218941 35107 50350734
Electrocardiogram QT prolonged 84.32 9.87 61 219222 51825 50334016
Hyponatraemia 83.18 9.87 183 219100 95956 50289885
Hepatocellular injury 80.73 9.87 9 219274 25938 50359903
Temperature regulation disorder 79.71 9.87 95 219188 4132 50381709
Helicobacter infection 78 9.87 423 218860 49279 50336562
Device expulsion 76.04 9.87 16 219267 28806 50357035
Maternal exposure during pregnancy 75.88 9.87 395 218888 159383 50226458
Lactic acidosis 75.70 9.87 25 219258 33330 50352511
Anaemia 74.36 9.87 717 218566 251739 50134102
Sopor 73.08 9.87 3 219280 19876 50365965
Rhabdomyolysis 72.94 9.87 39 219244 38988 50346853
Swelling 71.35 9.87 1245 218038 199627 50186214
Dyspnoea 69.66 9.87 2967 216316 544641 49841200
Duodenal ulcer perforation 68.77 9.87 384 218899 45227 50340614
Confusional state 67.32 9.87 1156 218127 184772 50201069
Drug reaction with eosinophilia and systemic symptoms 66.84 9.87 20 219263 28404 50357437
Hypotension 66.72 9.87 675 218608 234794 50151047
Pancytopenia 66.26 9.87 168 219115 83862 50301979
Bursitis 66.24 9.87 229 219054 21906 50363935
Blood pressure systolic abnormal 65.64 9.87 119 219164 7587 50378254
Heart rate increased 65.62 9.87 565 218718 76685 50309156
Condition aggravated 65.50 9.87 900 218383 296158 50089683
Leukopenia 64.83 9.87 121 219162 67407 50318434
Exposure during pregnancy 63.92 9.87 288 218995 120727 50265114
Coma 63.86 9.87 92 219191 56787 50329054
Pleural thickening 63.75 9.87 67 219216 2532 50383309
Pleural fibrosis 63.72 9.87 76 219207 3308 50382533
Presbyacusis 63.57 9.87 69 219214 2707 50383134
Food allergy 63.48 9.87 121 219162 8016 50377825
Cholestasis 63.23 9.87 16 219267 25385 50360456
Cardiac arrest 62.34 9.87 172 219111 83479 50302362
Hyperkalaemia 60.98 9.87 71 219212 48018 50337823
Drug resistance 60.59 9.87 6 219277 18983 50366858
Agranulocytosis 60.56 9.87 10 219273 21411 50364430
Bone marrow failure 60.46 9.87 22 219261 27602 50358239
Asthenia 60.06 9.87 1808 217475 317234 50068607
Osteonecrosis of jaw 60.06 9.87 33 219250 32493 50353348
Seizure 59.61 9.87 285 218998 117589 50268252
Epilepsy 58.94 9.87 11 219272 21556 50364285
Hypoglycaemia 58.85 9.87 88 219195 53493 50332348
Blood magnesium increased 58.09 9.87 67 219216 2813 50383028
Toxic epidermal necrolysis 56.74 9.87 11 219272 20981 50364860
Rash 55.00 9.87 2368 216915 435103 49950738
Hepatic function abnormal 53.65 9.87 38 219245 32643 50353198
Multiple organ dysfunction syndrome 53.06 9.87 85 219198 50252 50335589
Oropharyngeal pain 51.62 9.87 540 218743 77261 50308580
Sleep disorder 50.24 9.87 422 218861 56861 50328980
Cardio-respiratory arrest 49.61 9.87 99 219184 53793 50332048
Circulatory collapse 49.02 9.87 13 219270 19987 50365854
Depressed level of consciousness 48.20 9.87 95 219188 51858 50333983
Angioedema 47.37 9.87 56 219227 37620 50348221
Serotonin syndrome 47.21 9.87 24 219259 24689 50361152
Oxygen saturation decreased 47 9.87 505 218778 72743 50313098
Urine abnormality 46.50 9.87 91 219192 6147 50379694
Injection site pain 45.92 9.87 287 218996 110737 50275104
Deafness neurosensory 45.53 9.87 75 219208 4426 50381415
Epigastric discomfort 45.43 9.87 87 219196 5783 50380058
Cytomegalovirus infection 45.32 9.87 11 219272 17951 50367890
Drug abuse 44.62 9.87 123 219160 59723 50326118
Chest discomfort 44.51 9.87 605 218678 92117 50293724
Metabolic acidosis 44.37 9.87 62 219221 38763 50347078
Mucosal inflammation 44.01 9.87 66 219217 40076 50345765
Coeliac disease 43.50 9.87 108 219175 8577 50377264
Altered state of consciousness 42.27 9.87 21 219262 21889 50363952
Rheumatoid factor positive 42.21 9.87 96 219187 49763 50336078
C-reactive protein increased 42.21 9.87 147 219136 66327 50319514
Orthostatic hypotension 41.32 9.87 40 219243 29441 50356400
Blood pressure diastolic increased 40.98 9.87 96 219187 7347 50378494
Abdominal pain upper 40.66 9.87 940 218343 158369 50227472
Pyrexia 40.61 9.87 2025 217258 378178 50007663
Urine leukocyte esterase positive 40.51 9.87 56 219227 2827 50383014
Hypocalcaemia 40.43 9.87 34 219249 26782 50359059
Flushing 39.78 9.87 455 218828 66560 50319281
Malignant neoplasm progression 39.75 9.87 156 219127 67968 50317873
Injection site erythema 38.56 9.87 180 219103 74756 50311085
Renal failure 38.46 9.87 287 218996 106346 50279495
Septic shock 37.96 9.87 124 219159 57051 50328790
Intentional self-injury 37.77 9.87 27 219256 23085 50362756
Osteonecrosis 37.20 9.87 26 219257 22491 50363350
Gamma-glutamyltransferase increased 36.21 9.87 45 219238 29578 50356263
Osteopenia 36.16 9.87 158 219125 16860 50368981
Suicide attempt 35.89 9.87 110 219173 51622 50334219
Syncope 35.84 9.87 280 219003 102722 50283119
Bone cyst 35.74 9.87 44 219239 1980 50383861
Abortion spontaneous 34.90 9.87 81 219202 41691 50344150
Rash maculo-papular 34.13 9.87 39 219244 26602 50359239
Peptic ulcer haemorrhage 33.57 9.87 31 219252 998 50384843
Immunodeficiency 33.30 9.87 140 219143 14688 50371153
Generalised tonic-clonic seizure 33.19 9.87 39 219244 26271 50359570
Myelosuppression 32.72 9.87 9 219274 13508 50372333
Myoclonus 32.56 9.87 11 219272 14459 50371382
Bradycardia 32.42 9.87 156 219127 64270 50321571
Dyskinesia 32.33 9.87 44 219239 27817 50358024
Neovascularisation 32.05 9.87 30 219253 983 50384858
Red blood cells urine positive 31.87 9.87 49 219234 2726 50383115
Hypokalaemia 31.64 9.87 237 219046 87755 50298086
Melaena 31.60 9.87 42 219241 26822 50359019
Pancreatitis acute 31.45 9.87 34 219249 23778 50362063
Overdose 31.12 9.87 279 219004 99448 50286393
Skin necrosis 30.88 9.87 5 219278 10862 50374979
Accidental exposure to product 30.37 9.87 33 219250 23024 50362817
Influenza 30.32 9.87 551 218732 88987 50296854
Sedation 30.13 9.87 54 219229 30556 50355285
Lymphopenia 30.09 9.87 15 219268 15606 50370235
Drug-induced liver injury 30.02 9.87 47 219236 28048 50357793
Osteoarthritis 29.46 9.87 439 218844 68167 50317674
Chills 28.98 9.87 584 218699 96103 50289738
Sinus disorder 28.88 9.87 157 219126 18301 50367540
Cough 28.67 9.87 1299 217984 239965 50145876
Torsade de pointes 28.42 9.87 8 219275 11827 50374014
Foetal exposure during pregnancy 28.08 9.87 47 219236 27312 50358529
Interstitial lung disease 27.79 9.87 127 219156 53049 50332792
Agitation 27.60 9.87 128 219155 53256 50332585
Poisoning 27.02 9.87 10 219273 12419 50373422
Constipation 26.87 9.87 1021 218262 184687 50201154
Suicidal ideation 26.78 9.87 136 219147 55249 50330592
Renal impairment 26.63 9.87 205 219078 75456 50310385
Throat irritation 26.63 9.87 223 219060 30016 50355825
Rhinorrhoea 26.58 9.87 341 218942 51242 50334599
Product prescribing error 26.51 9.87 31 219252 20930 50364911
Eosinophilia 26.50 9.87 25 219258 18627 50367214
Upper respiratory tract infection 26.49 9.87 417 218866 65481 50320360
Wrong technique in product usage process 26.45 9.87 137 219146 55373 50330468
Disorientation 26.40 9.87 73 219210 35411 50350430
Red cell distribution width increased 26 9.87 89 219194 8470 50377371
Status epilepticus 25.63 9.87 13 219270 13393 50372448
Hypothermia 25.57 9.87 10 219273 12006 50373835
Parkinsonism 25.30 9.87 4 219279 8843 50376998
Drug ineffective 25.20 9.87 3139 216144 816194 49569647
Hepatotoxicity 25.06 9.87 50 219233 27176 50358665
Foetal death 25.04 9.87 3 219280 8177 50377664
Device dislocation 25.03 9.87 34 219249 21512 50364329
Lupus vasculitis 24.87 9.87 19 219264 468 50385373
Inappropriate antidiuretic hormone secretion 24.75 9.87 13 219270 13130 50372711
Nasal congestion 24.70 9.87 334 218949 50786 50335055
Blood creatine phosphokinase increased 24.64 9.87 48 219235 26319 50359522
Haematemesis 24.60 9.87 52 219231 27673 50358168
Haemophagocytic lymphohistiocytosis 24.47 9.87 4 219279 8629 50377212
Premature baby 24.42 9.87 26 219257 18311 50367530
Hepatic enzyme increased 24.03 9.87 772 218511 136608 50249233
Transplant rejection 24.02 9.87 6 219277 9603 50376238
Blood pressure diastolic decreased 23.79 9.87 139 219144 16642 50369199
Fluid retention 23.69 9.87 329 218954 50320 50335521
Cestode infection 23.59 9.87 15 219268 272 50385569
Treatment failure 23.56 9.87 437 218846 137200 50248641
Cyst 23.53 9.87 110 219173 12077 50373764
Labelled drug-drug interaction medication error 23.51 9.87 8 219275 10469 50375372
Alanine aminotransferase increased 23.46 9.87 257 219026 88102 50297739
Shock haemorrhagic 23.35 9.87 4 219279 8340 50377501
Live birth 23.30 9.87 22 219261 16386 50369455
Disease recurrence 23.01 9.87 32 219251 20049 50365792
Spinal meningioma benign 23.00 9.87 11 219272 110 50385731
Cerebral haemorrhage 22.97 9.87 52 219231 27000 50358841
Drug eruption 22.91 9.87 42 219241 23564 50362277
Pneumocystis jirovecii pneumonia 22.84 9.87 18 219265 14645 50371196
Aspartate aminotransferase increased 22.70 9.87 222 219061 77776 50308065
Rheumatic fever 22.37 9.87 24 219259 16843 50368998
Magnesium deficiency 22.28 9.87 18 219265 482 50385359
Haemodynamic instability 22.12 9.87 4 219279 8020 50377821
Injection site reaction 21.90 9.87 127 219156 49905 50335936
Ejection fraction decreased 21.74 9.87 29 219254 18491 50367350
Neutropenic sepsis 21.25 9.87 18 219265 14129 50371712
Liver disorder 21.22 9.87 86 219197 37136 50348705
Injection site swelling 21.10 9.87 101 219182 41672 50344169
Febrile neutropenia 21.07 9.87 297 218986 97370 50288471
Product substitution issue 20.97 9.87 18 219265 14039 50371802
Hypertensive crisis 20.68 9.87 16 219267 13138 50372703
Neurotoxicity 20.65 9.87 20 219263 14720 50371121
Cerebral infarction 20.47 9.87 39 219244 21565 50364276
Haematoma 20.37 9.87 66 219217 30444 50355397
Ear pruritus 20.24 9.87 38 219245 2488 50383353
Lower limb fracture 20.19 9.87 118 219165 14128 50371713
Therapeutic response decreased 20.08 9.87 121 219162 47110 50338731
Illness 20.05 9.87 178 219105 24362 50361479
Alopecia 19.99 9.87 863 218420 244184 50141657
Jaundice 19.93 9.87 54 219229 26375 50359466
Swollen joint count increased 19.90 9.87 21 219262 14852 50370989
Intentional overdose 19.87 9.87 174 219109 62330 50323511
Respiratory depression 19.66 9.87 14 219269 11996 50373845
Scoliosis 19.64 9.87 68 219215 6508 50379333
Creatinine renal clearance decreased 19.26 9.87 14 219269 11867 50373974
Thrombotic microangiopathy 19.24 9.87 7 219276 8784 50377057
Pain in extremity 19.18 9.87 1401 217882 271464 50114377
Sedation complication 19.15 9.87 7 219276 8759 50377082
Stevens-Johnson syndrome 19.13 9.87 41 219242 21711 50364130
Dry eye 19.08 9.87 218 219065 31877 50353964
Akathisia 18.97 9.87 6 219277 8223 50377618
Posterior reversible encephalopathy syndrome 18.96 9.87 22 219261 14906 50370935
White blood cells urine positive 18.92 9.87 53 219230 4525 50381316
Oliguria 18.92 9.87 6 219277 8210 50377631
Face oedema 18.91 9.87 30 219253 17809 50368032
Drug tolerance decreased 18.88 9.87 8 219275 9152 50376689
Diarrhoea 18.70 9.87 2863 216420 585613 49800228
Urinary sediment present 18.57 9.87 32 219251 1959 50383882
Psychotic disorder 18.46 9.87 42 219241 21770 50364071
Osteosclerosis 18.31 9.87 44 219239 3423 50382418
Heart rate decreased 18.27 9.87 240 219043 36257 50349584
Rheumatoid nodule 18.17 9.87 17 219266 12718 50373123
Diabetic ketoacidosis 18.07 9.87 31 219252 17841 50368000
Blood urine present 18.00 9.87 106 219177 12727 50373114
Lip pruritus 17.95 9.87 19 219264 724 50385117
Acute respiratory distress syndrome 17.55 9.87 41 219242 21058 50364783
Hip arthroplasty 17.54 9.87 70 219213 30359 50355482
Injection site pruritus 17.46 9.87 103 219180 40308 50345533
Pemphigus 17.45 9.87 392 218891 119774 50266067
Peritonitis 17.42 9.87 25 219258 15461 50370380
Knee arthroplasty 17.34 9.87 88 219195 35758 50350083
Delirium 17.23 9.87 96 219187 38096 50347745
Asthma 17.20 9.87 508 218775 88829 50297012
Chronic obstructive pulmonary disease 17.10 9.87 326 218957 53109 50332732
Injection site warmth 17.01 9.87 21 219262 13845 50371996
Off label use 16.77 9.87 1800 217483 472626 49913215
Hyperglycaemia 16.70 9.87 91 219192 36314 50349527
Bronchopulmonary aspergillosis 16.69 9.87 6 219277 7586 50378255
Mydriasis 16.61 9.87 13 219270 10614 50375227
Hepatitis 16.50 9.87 75 219208 31378 50354463
Feeling hot 16.49 9.87 250 219033 38952 50346889
Femur fracture 16.45 9.87 95 219188 37369 50348472
Colitis microscopic 16.43 9.87 4 219279 6516 50379325
Polyneuropathy 16.38 9.87 17 219266 12114 50373727
Treatment noncompliance 16.36 9.87 71 219212 30079 50355762
Productive cough 16.36 9.87 320 218963 52374 50333467
Left ventricular dysfunction 16.23 9.87 13 219270 10493 50375348
Full blood count decreased 16.20 9.87 158 219125 22188 50363653
Disseminated intravascular coagulation 16.18 9.87 31 219252 17104 50368737
Menstruation delayed 16.06 9.87 25 219258 1406 50384435
Hypercalcaemia 15.95 9.87 50 219233 23302 50362539
Anxiety 15.91 9.87 931 218352 176675 50209166
Loss of consciousness 15.84 9.87 338 218945 104015 50281826
Infusion site extravasation 15.77 9.87 66 219217 6910 50378931
Hepatic failure 15.76 9.87 79 219204 32204 50353637
Shock 15.72 9.87 42 219241 20608 50365233
Neuroleptic malignant syndrome 15.71 9.87 15 219268 11115 50374726
Hallucination, auditory 15.69 9.87 14 219269 10714 50375127
Lip dry 15.63 9.87 51 219232 4736 50381105
Seasonal allergy 15.56 9.87 113 219170 14563 50371278
Arteriovenous fistula occlusion 15.54 9.87 13 219270 366 50385475
Body height decreased 15.47 9.87 78 219205 8830 50377011
Sudden death 15.36 9.87 10 219273 8981 50376860
Aggression 15.29 9.87 44 219239 21072 50364769
Dermatitis bullous 15.21 9.87 6 219277 7167 50378674
Graft versus host disease 15.12 9.87 4 219279 6162 50379679
Foetal growth restriction 14.98 9.87 5 219278 6622 50379219
Body temperature fluctuation 14.97 9.87 29 219254 1944 50383897
Drug withdrawal syndrome 14.90 9.87 57 219226 25024 50360817
Product tampering 14.88 9.87 10 219273 200 50385641
Concussion 14.84 9.87 69 219214 7559 50378282
Corneal epithelium defect 14.80 9.87 12 219271 323 50385518
Genital haemorrhage 14.79 9.87 5 219278 6569 50379272
Migraine 14.75 9.87 429 218854 74851 50310990
Femoral neck fracture 14.72 9.87 7 219276 7483 50378358
Dystonia 14.70 9.87 18 219265 11908 50373933
Myelodysplastic syndrome 14.62 9.87 27 219256 15105 50370736
Premature delivery 14.57 9.87 53 219230 23610 50362231
Purpura 14.41 9.87 13 219270 9898 50375943
Unintentional medical device removal 14.37 9.87 3 219280 5432 50380409
Urogenital prolapse 14.27 9.87 5 219278 20 50385821
Abnormal behaviour 14.21 9.87 41 219242 19617 50366224
Bacterial test 14.09 9.87 21 219262 1136 50384705
Ventricular fibrillation 14.03 9.87 15 219268 10544 50375297
Creatinine urine decreased 14.02 9.87 9 219274 166 50385675
Proteinuria 14.01 9.87 32 219251 16565 50369276
Mite allergy 13.99 9.87 14 219269 499 50385342
Systemic lupus erythematosus 13.92 9.87 484 218799 140138 50245703
Acute generalised exanthematous pustulosis 13.89 9.87 11 219272 8927 50376914
Miosis 13.85 9.87 5 219278 6305 50379536
Therapeutic response shortened 13.76 9.87 66 219217 7323 50378518
Device use error 13.73 9.87 3 219280 5263 50380578
Enthesopathy 13.72 9.87 7 219276 7186 50378655
Bronchial secretion retention 13.70 9.87 24 219259 1489 50384352
Premenstrual syndrome 13.64 9.87 15 219268 597 50385244
Type 2 diabetes mellitus 13.62 9.87 90 219193 34285 50351556
Oligohydramnios 13.60 9.87 4 219279 5746 50380095
Nerve compression 13.43 9.87 66 219217 7396 50378445
Pathogen resistance 13.38 9.87 4 219279 5685 50380156
Haemodialysis 13.36 9.87 10 219273 8352 50377489
Culture urine positive 13.34 9.87 39 219244 3412 50382429
Caesarean section 13.32 9.87 30 219253 15609 50370232
Dysarthria 13.32 9.87 101 219182 37302 50348539
Large intestine perforation 13.27 9.87 8 219275 7486 50378355
Ischaemic stroke 13.26 9.87 31 219252 15917 50369924
Pericarditis 13.18 9.87 440 218843 78249 50307592
Jaundice cholestatic 13.15 9.87 3 219280 5108 50380733
Metastases to liver 13.07 9.87 44 219239 20060 50365781
Epstein-Barr virus infection 13.06 9.87 7 219276 6990 50378851
Device related infection 13.06 9.87 46 219237 20689 50365152
Enteritis 13.05 9.87 7 219276 6988 50378853
Vein collapse 13.00 9.87 15 219268 630 50385211
Injection site haematoma 12.97 9.87 5 219278 6055 50379786
Schizophrenia 12.95 9.87 8 219275 7389 50378452
Blue toe syndrome 12.80 9.87 12 219271 394 50385447
Acute myeloid leukaemia 12.77 9.87 29 219254 15045 50370796
No adverse event 12.76 9.87 89 219194 33489 50352352
Sneezing 12.59 9.87 104 219179 13940 50371901
Aplastic anaemia 12.58 9.87 9 219274 7694 50378147
Hyperthermia 12.56 9.87 9 219274 7687 50378154
Specific gravity urine increased 12.53 9.87 9 219274 201 50385640
International normalised ratio increased 12.48 9.87 123 219160 43029 50342812
Aspergillus infection 12.48 9.87 7 219276 6814 50379027
Rash erythematous 12.33 9.87 216 219067 34636 50351205
Hemiparesis 12.28 9.87 45 219238 20003 50365838
Lichen sclerosus 12.17 9.87 18 219265 967 50384874
Blood bilirubin increased 12.14 9.87 85 219198 31953 50353888
Pancreatitis 12.10 9.87 122 219161 42492 50343349
Product use issue 12.05 9.87 527 218756 148948 50236893
Post-traumatic neck syndrome 12.04 9.87 26 219257 1884 50383957
Weight fluctuation 12.00 9.87 62 219221 7086 50378755
Transaminases increased 11.98 9.87 71 219212 27753 50358088
Stress cardiomyopathy 11.89 9.87 10 219273 7877 50377964
Pulmonary fibrosis 11.81 9.87 60 219223 24377 50361464
Staphylococcal sepsis 11.79 9.87 8 219275 7028 50378813
Ascites 11.77 9.87 99 219184 35762 50350079
Sinus congestion 11.76 9.87 102 219181 13869 50371972
Bradyphrenia 11.71 9.87 6 219277 6146 50379695
Hypomagnesaemia 11.69 9.87 56 219227 23100 50362741
Urine ketone body present 11.67 9.87 29 219254 2304 50383537
Libido increased 11.63 9.87 20 219263 1223 50384618
Hyperadrenalism 11.62 9.87 4 219279 15 50385826
Encephalitis 11.57 9.87 9 219274 7371 50378470
Neuralgia 11.46 9.87 145 219138 21718 50364123
Sputum discoloured 11.38 9.87 98 219185 13297 50372544
Hyperbilirubinaemia 11.22 9.87 15 219268 9555 50376286
Endometrial disorder 11.20 9.87 14 219269 640 50385201
Stillbirth 11.04 9.87 6 219277 5946 50379895
Hypoalbuminaemia 11.01 9.87 16 219267 9844 50375997
Fall 10.99 9.87 1277 218006 333655 50052186
Cardiogenic shock 10.94 9.87 33 219250 15566 50370275
Muscle rigidity 10.93 9.87 16 219267 9813 50376028
Infusion site pain 10.84 9.87 91 219192 12255 50373586
Fracture 10.83 9.87 37 219246 16796 50369045
Anterior chamber cell 10.83 9.87 12 219271 482 50385359
Eczema 10.83 9.87 56 219227 22646 50363195
Cataract 10.81 9.87 275 219008 47025 50338816
Tubulointerstitial nephritis 10.79 9.87 32 219251 15179 50370662
Oligomenorrhoea 10.73 9.87 14 219269 668 50385173
Cardiovascular disorder 10.69 9.87 18 219265 10436 50375405
Drug level increased 10.68 9.87 45 219238 19223 50366618
Cognitive disorder 10.67 9.87 131 219152 43992 50341849
Multiple allergies 10.66 9.87 68 219215 8395 50377446
Hypoaesthesia 10.62 9.87 663 218620 126594 50259247
Atypical femur fracture 10.61 9.87 4 219279 4912 50380929
Aphasia 10.60 9.87 76 219207 28418 50357423
Polymenorrhoea 10.55 9.87 18 219265 1093 50384748
Bronchitis 10.50 9.87 552 218731 103607 50282234
Electrocardiogram QRS complex prolonged 10.49 9.87 5 219278 5339 50380502
Disability 10.49 9.87 25 219258 12750 50373091
Limb injury 10.49 9.87 134 219149 20116 50365725
Blood potassium increased 10.48 9.87 113 219170 16285 50369556
Poor quality sleep 10.32 9.87 114 219169 16532 50369309
Hallucination, visual 10.30 9.87 37 219246 16545 50369296
Soft tissue injury 10.28 9.87 21 219262 1463 50384378
Vitamin D decreased 10.26 9.87 67 219216 8339 50377502
Nephrogenic systemic fibrosis 10.23 9.87 3 219280 4319 50381522
Muscle strain 10.23 9.87 59 219224 7029 50378812
Second primary malignancy 10.14 9.87 9 219274 6905 50378936
Sternal fracture 10.14 9.87 25 219258 1977 50383864
Injection site bruising 10.14 9.87 106 219177 36662 50349179
Limb mass 10.12 9.87 30 219253 2645 50383196
Hepatic steatosis 10.09 9.87 63 219220 24321 50361520
Tenosynovitis 10.07 9.87 19 219264 10546 50375295
Tardive dyskinesia 10.06 9.87 10 219273 7269 50378572
Ventricular tachycardia 10.03 9.87 35 219248 15786 50370055
Tooth disorder 9.99 9.87 154 219129 24074 50361767
Necrosis 9.98 9.87 4 219279 4732 50381109
Hyperammonaemia 9.94 9.87 4 219279 4720 50381121
Device malfunction 9.89 9.87 33 219250 15088 50370753

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Infusion related reaction 270.32 10.37 468 85058 43418 29445583
Drug interaction 235.15 10.37 140 85386 197245 29291756
Fatigue 134.02 10.37 1451 84075 315370 29173631
Toxicity to various agents 110.49 10.37 209 85317 173452 29315549
Chills 103.85 10.37 445 85081 70855 29418146
Back pain 91.09 10.37 556 84970 101728 29387273
Blood pressure increased 87.03 10.37 433 85093 73370 29415631
Acute kidney injury 81.50 10.37 443 85083 264824 29224177
Blood pressure diastolic abnormal 75.26 10.37 61 85465 2490 29486511
Pain 68.82 10.37 778 84748 170654 29318347
Cough 67.63 10.37 610 84916 126117 29362884
Rhabdomyolysis 61.81 10.37 51 85475 60757 29428244
Arthralgia 60.30 10.37 643 84883 138974 29350027
Cardiac failure 60.06 10.37 85 85441 79202 29409799
Heart rate decreased 59.71 10.37 183 85343 24729 29464272
Blood pressure fluctuation 57.20 10.37 156 85370 19738 29469263
Completed suicide 55.22 10.37 111 85415 90135 29398866
Sinusitis 51.98 10.37 217 85309 34133 29454868
General physical health deterioration 51.34 10.37 141 85385 102716 29386285
Hyperkalaemia 50.39 10.37 62 85464 61330 29427671
C-reactive protein increased 48.98 10.37 34 85492 44229 29444772
Blood pressure systolic abnormal 48.13 10.37 44 85482 2117 29486884
Pain in extremity 44.60 10.37 502 85024 109931 29379070
Flushing 42.96 10.37 182 85344 28810 29460191
Chest discomfort 42.79 10.37 253 85273 45730 29443271
Cholestasis 42.77 10.37 8 85518 23454 29465547
Drug resistance 42.27 10.37 6 85520 21534 29467467
Rhinorrhoea 40.78 10.37 146 85380 21373 29467628
Drug reaction with eosinophilia and systemic symptoms 40.69 10.37 15 85511 27977 29461024
Peripheral swelling 39.85 10.37 318 85208 63421 29425580
Lactic acidosis 39.49 10.37 19 85507 30228 29458773
Agranulocytosis 39.14 10.37 6 85520 20334 29468667
Interstitial lung disease 38.82 10.37 67 85459 57651 29431350
Urticaria 38.25 10.37 280 85246 54380 29434621
Blood pressure systolic increased 37.83 10.37 121 85405 16724 29472277
Thrombocytopenia 37.60 10.37 232 85294 134591 29354410
Oxygen saturation decreased 37.26 10.37 240 85286 44697 29444304
Neutropenia 36.03 10.37 228 85298 131483 29357518
Hepatic function abnormal 35.08 10.37 37 85489 39222 29449779
Pulmonary function test decreased 34.68 10.37 51 85475 4112 29484889
Cytomegalovirus infection 32.81 10.37 13 85513 23202 29465799
Abdominal discomfort 32.72 10.37 244 85282 47659 29441342
Throat irritation 32.70 10.37 76 85450 8709 29480292
Multiple organ dysfunction syndrome 32.62 10.37 85 85441 63031 29425970
Headache 32.52 10.37 694 84832 173313 29315688
Renal impairment 31.90 10.37 124 85402 81209 29407792
Altered state of consciousness 31.84 10.37 9 85517 19880 29469121
Weight decreased 31.54 10.37 612 84914 150293 29338708
Vitamin D deficiency 31.45 10.37 57 85469 5472 29483529
Rash 31.08 10.37 743 84783 189076 29299925
Hypoglycaemia 30.82 10.37 58 85468 48288 29440713
Chronic obstructive pulmonary disease 30.50 10.37 213 85313 40742 29448259
Sleep disorder due to general medical condition, insomnia type 30.39 10.37 27 85499 1251 29487750
Pancreatitis acute 29.35 10.37 17 85509 24368 29464633
Bone marrow failure 29.17 10.37 22 85504 27427 29461574
Coma 29.16 10.37 43 85483 39407 29449594
Circulatory collapse 28.89 10.37 9 85517 18664 29470337
Contusion 28.87 10.37 171 85355 30924 29458077
Joint swelling 28.54 10.37 243 85283 49387 29439614
Bronchitis 28.20 10.37 193 85333 36675 29452326
Rheumatoid arthritis 28.06 10.37 174 85352 31978 29457023
Dyspnoea 27.87 10.37 1182 84344 325550 29163451
Septic shock 26.75 10.37 92 85434 62468 29426533
Leukopenia 26.54 10.37 77 85449 55126 29433875
Gamma-glutamyltransferase increased 26.45 10.37 23 85503 26714 29462287
Cerebral infarction 25.93 10.37 20 85506 24655 29464346
Nasopharyngitis 25.32 10.37 274 85252 59391 29429610
Nausea 24.77 10.37 1047 84479 288208 29200793
Neck pain 24.65 10.37 125 85401 21322 29467679
Melaena 24.01 10.37 33 85493 31143 29457858
Osteonecrosis 23.82 10.37 5 85521 13514 29475487
Pancytopenia 23.74 10.37 142 85384 83026 29405975
Hyperhidrosis 23.63 10.37 288 85238 64252 29424749
Epilepsy 23.42 10.37 12 85514 18420 29470581
Pleural thickening 22.62 10.37 13 85513 298 29488703
Dyspepsia 22.62 10.37 157 85369 29968 29459033
Heart rate increased 22.56 10.37 191 85335 38747 29450254
Dental caries 22.40 10.37 42 85484 4138 29484863
Anxiety 22.38 10.37 359 85167 85006 29403995
Musculoskeletal stiffness 22.38 10.37 185 85341 37273 29451728
Emotional distress 21.97 10.37 89 85437 13806 29475195
Drug intolerance 21.38 10.37 224 85302 48155 29440846
Foetal exposure during pregnancy 21.26 10.37 41 85485 33826 29455175
Drug hypersensitivity 21.16 10.37 296 85230 68110 29420891
Bradycardia 20.94 10.37 108 85418 65521 29423480
Constipation 20.87 10.37 454 85072 113706 29375295
Bone pain 20.82 10.37 107 85419 18345 29470656
Drug ineffective 20.67 10.37 850 84676 362320 29126681
Myelosuppression 20.58 10.37 5 85521 12222 29476779
Feeling hot 20.49 10.37 94 85432 15394 29473607
Condition aggravated 20.03 10.37 300 85226 145995 29343006
Pruritus 19.88 10.37 460 85066 116389 29372612
Depressed level of consciousness 19.66 10.37 49 85477 36893 29452108
Asthenia 19.50 10.37 784 84742 214466 29274535
Blood creatine phosphokinase increased 19.31 10.37 57 85469 40587 29448414
Unevaluable event 19.23 10.37 150 85376 29701 29459300
Extrapyramidal disorder 19.09 10.37 4 85522 10827 29478174
C-reactive protein decreased 19.09 10.37 23 85503 1528 29487473
Productive cough 19.00 10.37 155 85371 31104 29457897
Infusion site pruritus 18.72 10.37 14 85512 507 29488494
Muscle spasms 18.70 10.37 278 85248 64804 29424197
Eosinophilia 18.58 10.37 22 85504 22139 29466862
Labelled drug-drug interaction medication error 18.56 10.37 6 85520 12153 29476848
Lymphocyte count abnormal 18.51 10.37 15 85511 612 29488389
Metabolic acidosis 18.49 10.37 52 85474 37610 29451391
Hospice care 17.94 10.37 43 85483 5025 29483976
Throat tightness 17.84 10.37 53 85473 7038 29481963
Rhinalgia 17.79 10.37 12 85514 368 29488633
Osteoarthritis 17.74 10.37 101 85425 18002 29470999
Hypoxia 17.59 10.37 212 85314 47167 29441834
Intentional self-injury 17.57 10.37 7 85519 12454 29476547
Product use issue 17.30 10.37 226 85300 51218 29437783
Post concussion syndrome 17.26 10.37 8 85518 115 29488886
Pneumocystis jirovecii pneumonia 17.13 10.37 14 85512 16765 29472236
Mucosal inflammation 16.74 10.37 42 85484 31553 29457448
Body temperature decreased 16.62 10.37 68 85458 10596 29478405
Injury 16.57 10.37 103 85423 18943 29470058
Cerebral haemorrhage 16.48 10.37 42 85484 31384 29457617
Hip fracture 16.43 10.37 67 85459 10425 29478576
Dry skin 16.06 10.37 119 85407 23188 29465813
Upper-airway cough syndrome 15.88 10.37 30 85496 2973 29486028
Neutropenic sepsis 15.87 10.37 7 85519 11720 29477281
Oropharyngeal pain 15.59 10.37 141 85385 29144 29459857
Plasma cell myeloma 15.53 10.37 170 85356 36945 29452056
Jaundice 15.48 10.37 39 85487 29257 29459744
Nervous system neoplasm 15.41 10.37 8 85518 149 29488852
Nephropathy toxic 15.24 10.37 6 85520 10750 29478251
Maternal exposure before pregnancy 15.18 10.37 12 85514 472 29488529
Paranasal sinus hypersecretion 15.13 10.37 15 85511 799 29488202
Anaemia 14.90 10.37 455 85071 200496 29288505
Delirium 14.84 10.37 61 85465 39336 29449665
Drug eruption 14.70 10.37 16 85510 16725 29472276
Nephrolithiasis 14.53 10.37 124 85402 25210 29463791
Haematochezia 14.39 10.37 167 85359 36816 29452185
Peritonitis 14.36 10.37 13 85513 14811 29474190
Urinary tract infection 14.26 10.37 291 85235 72063 29416938
Wheezing 14.26 10.37 153 85373 33087 29455914
Treatment failure 14.04 10.37 57 85469 36882 29452119
Pneumonia 13.91 10.37 1090 84436 319082 29169919
Polyneuropathy 13.89 10.37 9 85517 12143 29476858
Progressive multifocal leukoencephalopathy 13.85 10.37 4 85522 8715 29480286
Liver disorder 13.85 10.37 38 85488 27711 29461290
Diabetes mellitus 13.59 10.37 64 85462 39767 29449234
Musculoskeletal pain 13.23 10.37 135 85391 28818 29460183
Toxic epidermal necrolysis 13.20 10.37 20 85506 18133 29470868
Paranasal sinus discomfort 13.08 10.37 13 85513 695 29488306
Full blood count decreased 12.99 10.37 85 85441 15907 29473094
Electrocardiogram QT prolonged 12.97 10.37 57 85469 36080 29452921
Urethral meatus stenosis 12.96 10.37 5 85521 44 29488957
Acute coronary syndrome 12.94 10.37 10 85516 12315 29476686
Sputum discoloured 12.83 10.37 45 85481 6518 29482483
Aplastic anaemia 12.78 10.37 3 85523 7507 29481494
Failure to thrive 12.78 10.37 50 85476 7634 29481367
Graft versus host disease 12.64 10.37 6 85520 9622 29479379
Cardio-respiratory arrest 12.60 10.37 90 85436 50511 29438490
Overdose 12.59 10.37 159 85367 79660 29409341
Hypoaesthesia 12.59 10.37 221 85305 53246 29435755
Anaphylactic shock 12.56 10.37 12 85514 13324 29475677
Acute respiratory failure 12.50 10.37 124 85402 26278 29462723
Anuria 12.44 10.37 6 85520 9535 29479466
Death 12.40 10.37 1149 84377 340935 29148066
Ascites 12.40 10.37 59 85467 36560 29452441
Nasal congestion 12.23 10.37 95 85431 18784 29470217
Joint effusion 12.21 10.37 33 85493 4151 29484850
Impaired work ability 12.20 10.37 40 85486 5600 29483401
Joint stiffness 12.16 10.37 57 85469 9416 29479585
Miosis 12.14 10.37 4 85522 8005 29480996
Hypocalcaemia 12.13 10.37 26 85500 20639 29468362
Anhedonia 12.09 10.37 47 85479 7153 29481848
Fear 12.07 10.37 57 85469 9447 29479554
Hepatic encephalopathy 11.96 10.37 12 85514 13023 29475978
Sinus disorder 11.79 10.37 41 85485 5914 29483087
Hyponatraemia 11.71 10.37 132 85394 67501 29421500
Hepatocellular carcinoma 11.61 10.37 3 85523 7035 29481966
Infusion site extravasation 11.58 10.37 27 85499 3100 29485901
Aortic bruit 11.57 10.37 7 85519 177 29488824
Illness 11.56 10.37 44 85482 6630 29482371
Pharyngeal paraesthesia 11.50 10.37 10 85516 450 29488551
Tubulointerstitial nephritis 11.39 10.37 21 85505 17622 29471379
Myocardial ischaemia 11.33 10.37 18 85508 16010 29472991
Ischaemic stroke 11.24 10.37 18 85508 15959 29473042
Disease recurrence 11.13 10.37 18 85508 15896 29473105
Lymphocyte count 11.10 10.37 5 85521 67 29488934
Hypertension 11.06 10.37 427 85099 116187 29372814
Disseminated intravascular coagulation 11.02 10.37 26 85500 19954 29469047
Appendix disorder 10.96 10.37 11 85515 595 29488406
Radial pulse abnormal 10.96 10.37 3 85523 7 29488994
Bile output abnormal 10.92 10.37 4 85522 30 29488971
Thrombosis 10.88 10.37 180 85346 42865 29446136
Parkinsonian rest tremor 10.87 10.37 6 85520 127 29488874
Hot flush 10.87 10.37 77 85449 14793 29474208
Psychotic disorder 10.83 10.37 27 85499 20327 29468674
Type IIa hyperlipidaemia 10.79 10.37 6 85520 129 29488872
Haematotoxicity 10.78 10.37 3 85523 6696 29482305
Weight increased 10.71 10.37 294 85232 76373 29412628
Blood pressure diastolic increased 10.69 10.37 29 85497 3657 29485344
Arthritis 10.65 10.37 115 85411 24904 29464097
Aspergillus infection 10.59 10.37 9 85517 10572 29478429
Cardiac arrest 10.53 10.37 179 85347 85412 29403589
Aggression 10.50 10.37 60 85466 35481 29453520
Generalised tonic-clonic seizure 10.48 10.37 25 85501 19114 29469887
Bronchial wall thickening 10.41 10.37 14 85512 1038 29487963

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug interaction 646.28 10.07 263 237346 361820 63899303
Infusion related reaction 491.26 10.07 1526 236083 162941 64098182
Toxicity to various agents 384.98 10.07 464 237145 363049 63898074
Sinusitis 374.42 10.07 1286 236323 144642 64116481
Irritable bowel syndrome 337.42 10.07 541 237068 36828 64224295
Muscle injury 315.15 10.07 436 237173 26001 64235122
Sleep disorder due to general medical condition, insomnia type 292.02 10.07 419 237190 25851 64235272
Folliculitis 286.13 10.07 446 237163 29631 64231492
Peripheral swelling 281.01 10.07 1515 236094 207638 64053485
Nasopharyngitis 273.45 10.07 1435 236174 194638 64066485
Completed suicide 267.80 10.07 259 237350 224155 64036968
Acute kidney injury 262.03 10.07 818 236791 448422 63812701
Rheumatoid arthritis 258.35 10.07 1244 236365 163050 64098073
Fatigue 244.56 10.07 3990 233619 744740 63516383
Pain 237.11 10.07 3093 234516 550418 63710705
Lower respiratory tract infection 229.69 10.07 819 236790 93795 64167328
Pruritus 200.58 10.07 1892 235717 310508 63950615
Blood pressure fluctuation 188.88 10.07 517 237092 51354 64209769
Joint swelling 186.92 10.07 1396 236213 213986 64047137
Gastrointestinal disorder 182.53 10.07 734 236875 88975 64172148
Back pain 181.94 10.07 1557 236052 248614 64012509
Ill-defined disorder 176.55 10.07 455 237154 43597 64217526
Blood pressure increased 173.99 10.07 1160 236449 171392 64089731
Blood pressure diastolic abnormal 172.12 10.07 216 237393 11701 64249422
Ear pain 167.05 10.07 318 237291 24818 64236305
Impaired healing 166.46 10.07 546 237063 59927 64201196
Body temperature increased 164.07 10.07 395 237214 36271 64224852
Weight increased 163.67 10.07 1344 236265 212004 64049119
Muscle spasticity 154.11 10.07 244 237365 16425 64244698
Contusion 146.44 10.07 816 236793 113149 64147974
Blister 142.57 10.07 634 236975 80333 64180790
Arthralgia 142.25 10.07 2353 235256 439907 63821216
Cardiac failure 140.84 10.07 168 237441 132205 64128918
Headache 140.33 10.07 2732 234877 526735 63734388
Blood pressure systolic increased 140.15 10.07 451 237158 49002 64212121
Rhabdomyolysis 135.74 10.07 85 237524 91641 64169482
Neutropenia 130.62 10.07 449 237160 239175 64021948
Hepatocellular injury 128.56 10.07 10 237599 45225 64215898
Helicobacter infection 126.58 10.07 369 237240 37993 64223130
Thrombocytopenia 121.53 10.07 420 237189 223381 64037742
Urticaria 117.74 10.07 937 236672 146380 64114743
Drug reaction with eosinophilia and systemic symptoms 116.78 10.07 28 237581 54189 64206934
Hyperkalaemia 115.61 10.07 121 237488 101008 64160115
Blood pressure systolic abnormal 115.53 10.07 162 237447 9780 64251343
General physical health deterioration 114.83 10.07 378 237231 204047 64057076
Lactic acidosis 113.58 10.07 42 237567 61368 64199755
Duodenal ulcer perforation 113.23 10.07 332 237277 34293 64226830
Hypersensitivity 110.91 10.07 1159 236450 195293 64065830
Night sweats 110.66 10.07 338 237271 35708 64225415
Heart rate increased 106.47 10.07 675 236934 98000 64163123
Cholestasis 105.25 10.07 19 237590 44853 64216270
Drug resistance 99.08 10.07 8 237601 35094 64226029
Stomatitis 97.55 10.07 715 236894 108890 64152233
Pancytopenia 95.79 10.07 244 237365 143065 64118058
Agranulocytosis 94.55 10.07 14 237595 38215 64222908
Temperature regulation disorder 92.69 10.07 95 237514 4116 64257007
Anaemia 92.51 10.07 920 236689 377760 63883363
Hepatic function abnormal 89.22 10.07 64 237545 64249 64196874
Oxygen saturation decreased 88.53 10.07 687 236922 106489 64154634
Leukopenia 86.45 10.07 150 237459 101092 64160031
Coma 86.12 10.07 118 237491 87497 64173626
Chest discomfort 86.02 10.07 726 236883 115380 64145743
Bone marrow failure 85.04 10.07 35 237574 47917 64213206
Pleural thickening 84.22 10.07 74 237535 2636 64258487
Multiple organ dysfunction syndrome 84.11 10.07 153 237456 101260 64159863
Chills 83.25 10.07 822 236787 136442 64124681
Hyponatraemia 82.78 10.07 275 237334 148064 64113059
Flushing 82.37 10.07 534 237075 78114 64183009
Pain in extremity 81.07 10.07 1567 236042 301518 63959605
Swelling 79.26 10.07 921 236688 159297 64101826
Insomnia 78.64 10.07 1092 236517 196744 64064379
Cytomegalovirus infection 78.58 10.07 20 237589 37179 64223944
Circulatory collapse 77.58 10.07 15 237594 33717 64227406
Electrocardiogram QT prolonged 77.08 10.07 108 237501 79340 64181783
Bursitis 77.05 10.07 213 237396 21272 64239851
Hypoglycaemia 76.91 10.07 133 237476 89759 64171364
Therapeutic product effect decreased 76.50 10.07 704 236905 114647 64146476
Oropharyngeal pain 76.38 10.07 575 237034 88292 64172831
Altered state of consciousness 75.18 10.07 23 237586 37879 64223244
Respiratory disorder 73.82 10.07 296 237313 35815 64225308
Osteoarthritis 73.80 10.07 442 237167 62894 64198229
Cardiac arrest 72.67 10.07 306 237303 153758 64107365
Septic shock 72.41 10.07 177 237432 105260 64155863
Food allergy 71.30 10.07 114 237495 7737 64253386
Pleural fibrosis 70.96 10.07 81 237528 3969 64257154
Epilepsy 70.88 10.07 18 237591 33513 64227610
Presbyacusis 69.59 10.07 65 237544 2510 64258613
Heart rate decreased 69.16 10.07 392 237217 54675 64206448
Depressed level of consciousness 66.51 10.07 124 237485 81312 64179811
Discomfort 63.79 10.07 513 237096 80365 64180758
Bradycardia 63.34 10.07 223 237386 117996 64143127
Cardio-respiratory arrest 63.08 10.07 171 237438 98222 64162901
Renal impairment 62.54 10.07 270 237339 134747 64126376
C-reactive protein increased 62.32 10.07 163 237446 94746 64166377
Interstitial lung disease 61.80 10.07 171 237438 97561 64163562
Blood magnesium increased 60.68 10.07 67 237542 3164 64257959
Abdominal discomfort 60.60 10.07 976 236633 181346 64079777
Toxic epidermal necrolysis 59.89 10.07 31 237578 37135 64223988
Mucosal inflammation 59.79 10.07 86 237523 62498 64198625
Metabolic acidosis 59.78 10.07 106 237503 70852 64190271
Pancreatitis acute 57.69 10.07 44 237565 42811 64218312
Melaena 56.88 10.07 68 237541 53480 64207643
Hepatic enzyme increased 56.87 10.07 730 236879 129213 64131910
Overdose 55.96 10.07 351 237258 159215 64101908
Cough 55.89 10.07 1483 236126 300665 63960458
Osteonecrosis of jaw 54.75 10.07 40 237569 39785 64221338
Rash 54.65 10.07 2135 235474 456414 63804709
Coeliac disease 54.55 10.07 98 237511 7314 64253809
Gamma-glutamyltransferase increased 54.35 10.07 59 237550 48451 64212672
Dyspnoea 53.70 10.07 3195 234414 715479 63545644
Arthropathy 53.11 10.07 680 236929 120287 64140836
Blood pressure diastolic increased 52.63 10.07 120 237489 10632 64250491
Rhinorrhoea 52.07 10.07 389 237220 59580 64201543
Angioedema 51.49 10.07 93 237516 61728 64199395
Hypotension 50.54 10.07 1045 236564 379929 63881194
Myelosuppression 49.97 10.07 13 237596 23817 64237306
Wound 49.30 10.07 464 237145 76013 64185110
Eosinophilia 48.86 10.07 41 237568 38035 64223088
Urine abnormality 48.73 10.07 93 237516 7269 64253854
Pericarditis 48.46 10.07 395 237214 62121 64199002
Influenza 48.11 10.07 602 237007 105929 64155194
Jaundice 48.00 10.07 65 237544 48447 64212676
Hand deformity 47.25 10.07 394 237215 62377 64198746
Anti-cyclic citrullinated peptide antibody positive 46.19 10.07 327 237282 49235 64211888
Throat irritation 45.88 10.07 240 237369 32471 64228652
Blood creatine phosphokinase increased 45.35 10.07 92 237517 58466 64202657
Osteopenia 45.17 10.07 143 237466 15397 64245726
Seizure 44.71 10.07 396 237213 166496 64094627
Rash maculo-papular 44.55 10.07 65 237544 46961 64214162
Labelled drug-drug interaction medication error 44.46 10.07 13 237596 22049 64239074
Anxiety 44.11 10.07 1017 236592 201632 64059491
Cerebral infarction 43.72 10.07 52 237557 40992 64220131
Osteonecrosis 43.37 10.07 25 237584 28204 64232919
Hypocalcaemia 42.27 10.07 55 237554 41698 64219425
Cerebral haemorrhage 41.53 10.07 78 237531 51012 64210111
Intentional self-injury 41.47 10.07 28 237581 29016 64232107
Infection 40.60 10.07 929 236680 183951 64077172
Drug eruption 40.43 10.07 44 237565 36092 64225031
Urine leukocyte esterase positive 40.36 10.07 56 237553 3347 64257776
Nephropathy toxic 39.83 10.07 8 237601 17506 64243617
Asthenia 39.62 10.07 1942 235667 426102 63835021
Feeling hot 39.52 10.07 296 237313 45367 64215756
Red cell distribution width increased 39.26 10.07 117 237492 12192 64248931
Blood pressure diastolic decreased 38.75 10.07 174 237435 22127 64238996
Parkinsonism 38.62 10.07 4 237605 14369 64246754
Nasal congestion 38.47 10.07 362 237247 59296 64201827
Condition aggravated 38.47 10.07 1061 236548 371365 63889758
Device expulsion 38.17 10.07 15 237594 21121 64240002
Torsade de pointes 37.32 10.07 9 237600 17354 64243769
Bone cyst 36.91 10.07 43 237566 2154 64258969
Migraine 36.83 10.07 373 237236 62304 64198819
Haematotoxicity 36.23 10.07 3 237606 12893 64248230
Neovascularisation 36.06 10.07 31 237578 1072 64260051
Skin necrosis 36.01 10.07 5 237604 14324 64246799
Renal failure 35.78 10.07 463 237146 181225 64079898
Orthostatic hypotension 35.71 10.07 74 237535 46664 64214459
Cyst 35.26 10.07 111 237498 11916 64249207
Immunodeficiency 35.25 10.07 135 237474 15989 64245134
Hepatotoxicity 35.21 10.07 58 237551 39904 64221219
Pneumocystis jirovecii pneumonia 35.16 10.07 30 237579 27604 64233519
Liver disorder 34.73 10.07 92 237517 53259 64207864
Epigastric discomfort 34.44 10.07 77 237532 6734 64254389
Deafness neurosensory 34.43 10.07 74 237535 6300 64254823
Poisoning 34.15 10.07 19 237590 21860 64239263
Product prescribing error 34.15 10.07 48 237561 35221 64225902
Generalised tonic-clonic seizure 34.05 10.07 59 237550 39798 64221325
Dyskinesia 33.93 10.07 58 237551 39330 64221793
Productive cough 33.61 10.07 415 237194 72788 64188335
Contraindicated product administered 33.49 10.07 571 237038 107258 64153865
Delirium 32.87 10.07 137 237472 69057 64192066
Hypokalaemia 32.75 10.07 289 237320 121614 64139509
Inappropriate antidiuretic hormone secretion 32.48 10.07 21 237588 22268 64238855
Neutropenic sepsis 32.48 10.07 23 237586 23249 64237874
Haematemesis 32.17 10.07 79 237530 46920 64214203
Graft versus host disease 32.06 10.07 6 237603 13807 64247316
Shock haemorrhagic 31.87 10.07 11 237598 16780 64244343
Haemodynamic instability 31.53 10.07 8 237601 14904 64246219
Malignant neoplasm progression 31.48 10.07 265 237344 112606 64148517
Hepatic failure 30.67 10.07 103 237506 55291 64205832
Chronic obstructive pulmonary disease 30.58 10.07 398 237211 70650 64190473
Suicide attempt 30.47 10.07 146 237463 70861 64190262
Upper respiratory tract infection 30.20 10.07 405 237204 72380 64188743
Disorientation 30.10 10.07 105 237504 55723 64205400
Weight decreased 29.97 10.07 1313 236296 284426 63976697
Scoliosis 29.90 10.07 68 237541 6014 64255109
Glossodynia 29.80 10.07 367 237242 64329 64196794
Abdominal pain upper 29.74 10.07 850 236759 174180 64086943
Disease recurrence 29.41 10.07 44 237565 31466 64229657
Bronchopulmonary aspergillosis 29.18 10.07 17 237592 19068 64242055
Off label use 28.99 10.07 1975 235634 630831 63630292
Syncope 28.76 10.07 408 237201 157227 64103896
Synovitis 28.72 10.07 519 237090 98571 64162552
Oliguria 28.63 10.07 9 237600 14567 64246556
Miosis 28.27 10.07 7 237602 13259 64247864
Status epilepticus 28.20 10.07 23 237586 21640 64239483
Illness 28.09 10.07 157 237452 21781 64239342
Posterior reversible encephalopathy syndrome 27.88 10.07 26 237583 22920 64238203
Lymphopenia 27.87 10.07 32 237577 25625 64235498
Product use in unapproved indication 27.86 10.07 470 237139 176148 64084975
Hypothermia 27.22 10.07 20 237589 19836 64241287
Fluid retention 26.97 10.07 337 237272 59269 64201854
Aggression 26.96 10.07 84 237525 46148 64214975
Purpura 26.89 10.07 15 237594 17231 64243892
Dry eye 26.76 10.07 191 237418 28828 64232295
Hepatitis cholestatic 26.72 10.07 6 237603 12149 64248974
Disseminated intravascular coagulation 26.63 10.07 49 237560 32299 64228824
Myoclonus 26.56 10.07 32 237577 25086 64236037
Systemic lupus erythematosus 26.32 10.07 417 237192 77195 64183928
Cestode infection 26.29 10.07 15 237594 263 64260860
Drug level increased 26.24 10.07 54 237555 34142 64226981
Epstein-Barr virus infection 25.83 10.07 7 237602 12481 64248642
Neck pain 25.77 10.07 343 237266 61190 64199933
Infusion site extravasation 25.73 10.07 69 237540 6768 64254355
Ascites 25.73 10.07 129 237480 61872 64199251
Osteosclerosis 25.54 10.07 46 237563 3440 64257683
Hypoaesthesia 25.44 10.07 682 236927 138426 64122697
Pemphigus 25.28 10.07 338 237271 60363 64200760
Myelodysplastic syndrome 25.27 10.07 39 237570 27540 64233583
Lupus vasculitis 25.14 10.07 18 237591 474 64260649
Polyneuropathy 24.82 10.07 22 237587 19872 64241251
Drug-induced liver injury 24.76 10.07 91 237518 47552 64213571
Hyperglycaemia 24.65 10.07 128 237481 60840 64200283
Psychotic disorder 24.56 10.07 57 237552 34521 64226602
Accidental exposure to product 24.42 10.07 37 237572 26327 64234796
Sputum discoloured 24.35 10.07 130 237479 17726 64243397
Wrong technique in product usage process 24.30 10.07 140 237469 64834 64196289
Peritonitis 24.28 10.07 34 237575 24989 64236134
Neuroleptic malignant syndrome 24.22 10.07 34 237575 24962 64236161
Pathogen resistance 24.18 10.07 8 237601 12535 64248588
Bronchitis 24.03 10.07 547 237062 108196 64152927
Blood urine present 23.98 10.07 132 237477 18208 64242915
Thrombotic microangiopathy 23.86 10.07 16 237593 16639 64244484
Tubulointerstitial nephritis 23.56 10.07 49 237560 30860 64230263
Dystonia 23.37 10.07 21 237588 18844 64242279
Aplastic anaemia 23.35 10.07 11 237598 13909 64247214
Acute coronary syndrome 23.32 10.07 22 237587 19288 64241835
Transplant rejection 23.25 10.07 18 237591 17383 64243740
Stress 23.15 10.07 332 237277 60202 64200921
Aspergillus infection 23.11 10.07 16 237593 16363 64244760
Stevens-Johnson syndrome 23.10 10.07 58 237551 34191 64226932
Red blood cells urine positive 23.06 10.07 51 237558 4427 64256696
Ischaemic stroke 23.01 10.07 45 237564 28990 64232133
Drug abuse 22.96 10.07 346 237263 132028 64129095
White blood cells urine positive 22.91 10.07 57 237552 5341 64255782
Spinal meningioma benign 22.82 10.07 10 237599 96 64261027
Proteinuria 22.82 10.07 42 237567 27681 64233442
Dyspepsia 22.70 10.07 419 237190 79893 64181230
Urinary sediment present 22.46 10.07 34 237575 2200 64258923
Lower limb fracture 22.28 10.07 104 237505 13441 64247682
Hepatic encephalopathy 22.10 10.07 27 237582 21039 64240084
Drug intolerance 22.00 10.07 874 236735 187118 64074005
Creatinine renal clearance decreased 21.83 10.07 13 237596 14408 64246715
Haematuria 21.71 10.07 132 237477 60339 64200784
Suicidal ideation 21.48 10.07 150 237459 66392 64194731
Ejection fraction decreased 21.47 10.07 46 237563 28661 64232462
Hyperhidrosis 21.31 10.07 607 237002 124313 64136810
Dysarthria 21.16 10.07 130 237479 59276 64201847
Acute respiratory distress syndrome 21.14 10.07 73 237536 38862 64222261
Neuralgia 21.13 10.07 167 237442 26017 64235106
Limb mass 21.04 10.07 39 237570 2982 64258141
Hypomagnesaemia 21.03 10.07 69 237540 37307 64223816
Febrile neutropenia 20.81 10.07 529 237080 187128 64073995
Injection site pain 20.44 10.07 288 237321 111120 64150003
Serotonin syndrome 20.43 10.07 75 237534 39207 64221916
Asthma 20.42 10.07 477 237132 94748 64166375
Alanine aminotransferase increased 20.31 10.07 375 237234 138656 64122467
Injection site erythema 20.29 10.07 165 237444 70635 64190488
Musculoskeletal stiffness 20.28 10.07 596 237013 122610 64138513
Haemophagocytic lymphohistiocytosis 20.19 10.07 21 237588 17588 64243535
Exposure during pregnancy 20.05 10.07 186 237423 77489 64183634
Sleep disorder 19.94 10.07 320 237289 59389 64201734
Lip dry 19.90 10.07 51 237558 4867 64256256
Drug dependence 19.79 10.07 60 237549 33252 64227871
Respiratory depression 19.76 10.07 35 237574 23408 64237715
Agitation 19.75 10.07 219 237390 88148 64172975
Upper-airway cough syndrome 19.64 10.07 74 237535 8696 64252427
Hyperthermia 19.64 10.07 17 237592 15533 64245590
Musculoskeletal pain 19.57 10.07 414 237195 80880 64180243
Progressive multifocal leukoencephalopathy 19.52 10.07 23 237586 18209 64242914
Lip pruritus 19.45 10.07 18 237591 687 64260436
Hepatitis 19.39 10.07 94 237515 45488 64215635
Ear pruritus 19.36 10.07 35 237574 2625 64258498
Sedation complication 19.28 10.07 7 237602 10347 64250776
Pemphigoid 19.25 10.07 12 237597 12974 64248149
Arteriovenous fistula occlusion 19.12 10.07 16 237593 533 64260590
Sinus disorder 19.05 10.07 117 237492 16791 64244332
Cytomegalovirus viraemia 19.04 10.07 8 237601 10820 64250303
Feeling abnormal 19.01 10.07 635 236974 132967 64128156
Anterior chamber cell 18.88 10.07 19 237590 805 64260318
Body height decreased 18.83 10.07 66 237543 7488 64253635
Hepatitis B 18.78 10.07 3 237606 7742 64253381
Magnesium deficiency 18.76 10.07 16 237593 547 64260576
Muscle spasms 18.74 10.07 665 236944 140358 64120765
Concussion 18.63 10.07 68 237541 7870 64253253
Hallucination, auditory 18.54 10.07 21 237588 16918 64244205
Sedation 18.53 10.07 84 237525 41378 64219745
Hypertensive crisis 18.51 10.07 24 237585 18224 64242899
Nausea 18.49 10.07 3226 234383 782574 63478549
Constipation 18.43 10.07 1027 236582 228310 64032813
Blood creatinine increased 18.38 10.07 371 237238 135411 64125712
Exostosis 18.22 10.07 87 237522 11351 64249772
Enteritis 18.12 10.07 11 237598 12066 64249057
Akathisia 17.96 10.07 10 237599 11500 64249623
Corneal epithelium defect 17.95 10.07 17 237592 668 64260455
Urinary tract infection 17.81 10.07 1033 236576 230563 64030560
Culture urine positive 17.80 10.07 44 237565 4107 64257016
Throat tightness 17.76 10.07 146 237463 23014 64238109
Gastric disorder 17.75 10.07 175 237434 29022 64232101
Premenstrual syndrome 17.69 10.07 15 237594 509 64260614
BK virus infection 17.68 10.07 3 237606 7409 64253714
Product substitution issue 17.60 10.07 24 237585 17837 64243286
Body temperature fluctuation 17.48 10.07 38 237571 3260 64257863
Deformity 17.44 10.07 57 237552 6240 64254883
Face oedema 17.44 10.07 41 237568 24720 64236403
Cholangitis 17.42 10.07 9 237600 10793 64250330
Shock 17.37 10.07 77 237532 38163 64222960
Neurotoxicity 17.27 10.07 48 237561 27356 64233767
Failure to thrive 17.20 10.07 80 237529 10324 64250799
Pulmonary tuberculosis 17.13 10.07 3 237606 7241 64253882
Influenza like illness 17.12 10.07 321 237288 61381 64199742
Potentiating drug interaction 17.01 10.07 4 237605 7848 64253275
Rheumatoid nodule 17.01 10.07 13 237596 12638 64248485
Death 16.99 10.07 1539 236070 481166 63779957
Asphyxia 16.93 10.07 7 237602 9559 64251564
Sternal fracture 16.91 10.07 30 237579 2217 64258906
Menstruation delayed 16.72 10.07 21 237588 1138 64259985
Immune reconstitution inflammatory syndrome 16.53 10.07 13 237596 12457 64248666
Dental caries 16.38 10.07 81 237528 10719 64250404
Drug tolerance decreased 16.33 10.07 3 237606 6995 64254128
Acute myocardial infarction 16.29 10.07 171 237438 69547 64191576
Disturbance in attention 16.17 10.07 87 237522 40987 64220136
Diabetic ketoacidosis 16.17 10.07 56 237553 29789 64231334
Cardiogenic shock 16.16 10.07 63 237546 32364 64228759
Congestive cardiomyopathy 16.12 10.07 9 237600 10335 64250788
Tenosynovitis 16.11 10.07 12 237597 11821 64249302
Bacterial test 16.05 10.07 21 237588 1186 64259937
Electrocardiogram QRS complex prolonged 15.98 10.07 7 237602 9237 64251886
Acute myeloid leukaemia 15.94 10.07 50 237559 27413 64233710
Jaundice cholestatic 15.91 10.07 6 237603 8664 64252459
Product tampering 15.90 10.07 10 237599 211 64260912
Infusion site pain 15.78 10.07 78 237531 10319 64250804
Pulmonary function test decreased 15.72 10.07 56 237553 6405 64254718
Ventricular fibrillation 15.64 10.07 41 237568 23819 64237304
Polymenorrhoea 15.61 10.07 18 237591 892 64260231
Encephalitis 15.56 10.07 14 237595 12557 64248566
Hypersensitivity vasculitis 15.56 10.07 3 237606 6758 64254365
Left ventricular dysfunction 15.51 10.07 24 237585 16930 64244193
Cystitis haemorrhagic 15.47 10.07 5 237604 7951 64253172
Dermatitis bullous 15.44 10.07 13 237596 12041 64249082
Aspartate aminotransferase increased 15.42 10.07 330 237279 119458 64141665
Nephrotic syndrome 15.38 10.07 8 237601 9559 64251564
Intestinal ischaemia 15.36 10.07 12 237597 11537 64249586
Arrhythmia 15.35 10.07 123 237486 52821 64208302
Hypoalbuminaemia 15.25 10.07 26 237583 17648 64243475
Immunosuppressant drug level increased 15.14 10.07 4 237605 7255 64253868
Post-traumatic neck syndrome 15.10 10.07 26 237583 1876 64259247
Urogenital prolapse 15.06 10.07 5 237604 20 64261103
Cognitive disorder 15.05 10.07 130 237479 54957 64206166
Skin toxicity 15.04 10.07 3 237606 6599 64254524
Acute pulmonary oedema 15.00 10.07 15 237594 12794 64248329
Hyperammonaemia 14.89 10.07 9 237600 9895 64251228
Emotional distress 14.72 10.07 200 237409 35838 64225285
Device use error 14.62 10.07 3 237606 6468 64254655
Hyperthyroidism 14.56 10.07 28 237581 18151 64242972
Band sensation 14.56 10.07 15 237594 654 64260469
Live birth 14.45 10.07 12 237597 11192 64249931
Pulmonary alveolar haemorrhage 14.43 10.07 9 237600 9729 64251394
Type IIa hyperlipidaemia 14.43 10.07 9 237600 187 64260936
Sneezing 14.42 10.07 101 237508 15150 64245973
Hip fracture 14.38 10.07 158 237451 26941 64234182
Oligomenorrhoea 14.37 10.07 14 237595 570 64260553
Nerve compression 14.33 10.07 60 237549 7401 64253722
Intentional overdose 14.28 10.07 239 237370 89705 64171418
Tardive dyskinesia 14.28 10.07 8 237601 9170 64251953
Platelet count decreased 14.28 10.07 490 237119 167221 64093902
Leukoencephalopathy 14.23 10.07 4 237605 6963 64254160
Hepatitis acute 14.22 10.07 17 237592 13372 64247751
Liver function test abnormal 14.17 10.07 145 237464 59256 64201867
Lichen sclerosus 14.15 10.07 17 237592 880 64260243
Body temperature decreased 14.14 10.07 152 237457 25776 64235347
Urine ketone body present 14.12 10.07 35 237574 3272 64257851
Full blood count decreased 14.04 10.07 136 237473 22446 64238677
Endometrial disorder 14.00 10.07 13 237596 498 64260625
Chronic graft versus host disease 14.00 10.07 3 237606 6273 64254850
Cataract 13.98 10.07 266 237343 50996 64210127
Colitis microscopic 13.88 10.07 5 237604 7427 64253696
Chest X-ray abnormal 13.84 10.07 55 237554 6626 64254497
Second primary malignancy 13.82 10.07 15 237594 12322 64248801
Facet joint syndrome 13.74 10.07 25 237584 1884 64259239
Hot flush 13.69 10.07 243 237366 45992 64215131
Mean cell haemoglobin concentration decreased 13.68 10.07 37 237572 3647 64257476
Haematoma 13.61 10.07 107 237502 46143 64214980
Mucormycosis 13.61 10.07 5 237604 7336 64253787
Bradyphrenia 13.52 10.07 9 237600 9397 64251726
Unintentional medical device removal 13.51 10.07 4 237605 6730 64254393
Specific gravity urine increased 13.50 10.07 12 237597 434 64260689
Nervous system disorder 13.40 10.07 42 237567 23036 64238087
Large intestine perforation 13.39 10.07 16 237593 12588 64248535
International normalised ratio increased 13.36 10.07 208 237401 78959 64182164
Ventricular tachycardia 13.26 10.07 73 237536 34192 64226931
Creatinine urine decreased 13.26 10.07 9 237600 217 64260906
Lymphocyte count decreased 13.17 10.07 217 237392 40482 64220641
Stress cardiomyopathy 13.11 10.07 9 237600 9248 64251875
Injury 13.10 10.07 284 237325 55708 64205415
Renal tubular disorder 13.07 10.07 3 237606 5984 64255139
Muscle rigidity 13.06 10.07 28 237581 17445 64243678
Drug withdrawal syndrome 13.04 10.07 65 237544 31226 64229897
Catatonia 12.82 10.07 6 237603 7614 64253509
Eczema 12.81 10.07 61 237548 29659 64231464
Sinus congestion 12.75 10.07 99 237510 15340 64245783
Poor quality sleep 12.72 10.07 116 237493 18835 64242288
Cutaneous vasculitis 12.71 10.07 4 237605 6469 64254654
Finger deformity 12.66 10.07 45 237564 5141 64255982
Blue toe syndrome 12.65 10.07 13 237596 565 64260558
Urethral meatus stenosis 12.53 10.07 5 237604 37 64261086
Weight fluctuation 12.48 10.07 62 237547 8220 64252903
Pancreatitis 12.43 10.07 150 237459 59457 64201666
Scratch 12.32 10.07 52 237557 6437 64254686
Mania 12.26 10.07 26 237583 16260 64244863
Metastases to liver 12.26 10.07 46 237563 23895 64237228
Haemodialysis 12.25 10.07 28 237581 17049 64244074
Multiple sclerosis 12.24 10.07 115 237494 18826 64242297
Infusion site erythema 12.22 10.07 54 237555 6819 64254304
Ileus paralytic 12.17 10.07 8 237601 8407 64252716
Dry mouth 12.14 10.07 300 237309 60118 64201005
Hypertriglyceridaemia 12.14 10.07 14 237595 11191 64249932
Multiple sclerosis relapse 12.11 10.07 216 237393 40919 64220204
Device dislocation 11.98 10.07 39 237570 21139 64239984
Mite allergy 11.90 10.07 14 237595 709 64260414
Hemiparesis 11.84 10.07 63 237546 29764 64231359
Metastases to lung 11.80 10.07 24 237585 15240 64245883
Diabetes mellitus 11.78 10.07 173 237436 66301 64194822
Soft tissue injury 11.78 10.07 21 237588 1558 64259565
Nitrite urine present 11.77 10.07 17 237592 1055 64260068
Adenovirus infection 11.76 10.07 6 237603 7249 64253874
Exposure to toxic agent 11.75 10.07 4 237605 6155 64254968
Wheezing 11.71 10.07 384 237225 80195 64180928
Myocardial ischaemia 11.69 10.07 45 237564 23206 64237917
Enthesopathy 11.62 10.07 11 237598 9627 64251496
Poor venous access 11.61 10.07 82 237527 12335 64248788
Tooth disorder 11.61 10.07 130 237479 22272 64238851
Hypercalcaemia 11.58 10.07 68 237541 31348 64229775
Tumour lysis syndrome 11.56 10.07 35 237574 19405 64241718
Limb injury 11.55 10.07 135 237474 23370 64237753
Necrosis 11.50 10.07 8 237601 8163 64252960
Hallucination, visual 11.50 10.07 58 237551 27776 64233347
Polyuria 11.47 10.07 18 237591 12625 64248498
Hospice care 11.43 10.07 57 237552 7568 64253555
Post concussion syndrome 11.43 10.07 12 237597 535 64260588
Punctate keratitis 11.42 10.07 15 237594 850 64260273
Arteriospasm coronary 11.42 10.07 3 237606 5462 64255661
Cryopyrin associated periodic syndrome 11.41 10.07 5 237604 48 64261075
Myocarditis 11.39 10.07 29 237580 17014 64244109
Anhedonia 11.38 10.07 88 237521 13618 64247505
Hyperbilirubinaemia 11.35 10.07 40 237569 21165 64239958
Rib fracture 11.34 10.07 137 237472 23901 64237222
Pharyngeal paraesthesia 11.22 10.07 23 237586 1894 64259229
Abortion spontaneous 11.20 10.07 51 237558 25092 64236031
Human papilloma virus test positive 11.17 10.07 11 237598 454 64260669
Rash erythematous 11.16 10.07 246 237363 48387 64212736
Loss of consciousness 11.16 10.07 440 237169 147925 64113198
Staphylococcal sepsis 11.10 10.07 19 237590 12880 64248243
Rash pustular 11.10 10.07 12 237597 9873 64251250
Biopsy kidney 11.07 10.07 7 237602 149 64260974
Hepatosplenomegaly 11.04 10.07 3 237606 5340 64255783
Schizophrenia 11.01 10.07 15 237594 11153 64249970
Oral pain 11.00 10.07 152 237457 27341 64233782
Head discomfort 10.98 10.07 78 237531 11756 64249367
Nephrogenic systemic fibrosis 10.94 10.07 4 237605 5888 64255235
Joint stiffness 10.93 10.07 165 237444 30239 64230884
Toxic encephalopathy 10.92 10.07 12 237597 9803 64251320
Musculoskeletal chest pain 10.84 10.07 124 237485 21355 64239768
Urine analysis abnormal 10.83 10.07 46 237563 5710 64255413
Blood bilirubin increased 10.83 10.07 148 237461 57405 64203718
Peripheral ischaemia 10.77 10.07 9 237600 8369 64252754
Hyperuricaemia 10.76 10.07 13 237596 10178 64250945
Muscle strain 10.73 10.07 59 237550 8135 64252988
Urine leukocyte esterase 10.71 10.07 7 237602 158 64260965
Alopecia 10.70 10.07 728 236881 164962 64096161
Dermatitis allergic 10.65 10.07 25 237584 15084 64246039
Therapeutic response shortened 10.61 10.07 69 237540 10101 64251022
Febrile nonhaemolytic transfusion reaction 10.60 10.07 4 237605 25 64261098
Urinary retention 10.57 10.07 123 237486 49078 64212045
Gait disturbance 10.52 10.07 753 236856 171402 64089721
Tuberculosis 10.51 10.07 20 237589 13018 64248105
Therapy non-responder 10.50 10.07 175 237434 65724 64195399
Sudden infant death syndrome 10.49 10.07 7 237602 164 64260959
Respiratory failure 10.46 10.07 486 237123 160697 64100426
Encephalopathy 10.45 10.07 153 237456 58666 64202457
Hiatus hernia strangulated 10.41 10.07 7 237602 166 64260957
Flatulence 10.40 10.07 187 237422 35479 64225644
Pharyngeal disorder 10.39 10.07 22 237587 1853 64259270
Extrapyramidal disorder 10.38 10.07 37 237572 19515 64241608
Ligament sprain 10.34 10.07 72 237537 10780 64250343
Hangover 10.19 10.07 22 237587 1879 64259244
Transaminases increased 10.17 10.07 110 237499 44484 64216639
Cerebral haematoma 10.16 10.07 7 237602 7178 64253945
Protein urine present 10.11 10.07 62 237547 8894 64252229
Maternal exposure before pregnancy 10.08 10.07 32 237577 3451 64257672

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R05CA03 RESPIRATORY SYSTEM
COUGH AND COLD PREPARATIONS
EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH SUPPRESSANTS
Expectorants
FDA PE N0000008867 Decreased Respiratory Secretion Viscosity
FDA PE N0000009560 Increased Respiratory Secretions
MeSH PA D005100 Expectorants
MeSH PA D019141 Respiratory System Agents
FDA EPC N0000193956 Expectorant

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Sinus headache indication 4969004
Cough indication 49727002
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Rhinitis indication 70076002 DOID:4483
Common cold indication 82272006 DOID:10459
Headache disorder indication 230461009
Influenza-like symptoms indication 315642008
Fever indication 386661006
Asthma off-label use 195967001 DOID:2841
Asthma-chronic obstructive pulmonary disease overlap syndrome off-label use 10692761000119107
Chronic Obstructive Pulmonary Disease with Bronchospasms off-label use
COPD Associated with Chronic Bronchitis off-label use
Metabolic alkalosis contraindication 1388004
Brain damage contraindication 2470005
Anuria contraindication 2472002 DOID:2983
Necrotizing enterocolitis in fetus OR newborn contraindication 2707005
Ocular hypertension contraindication 4210003 DOID:9282
Gastritis contraindication 4556007 DOID:4029
Hypocalcemia contraindication 5291005
Tachyarrhythmia contraindication 6285003
Suicidal thoughts contraindication 6471006
Dependent drug abuse contraindication 6525002
Urinary tract obstruction contraindication 7163005 DOID:5200
Alcoholism contraindication 7200002
Alcohol withdrawal delirium contraindication 8635005
Hyperammonemia contraindication 9360008
Peptic ulcer contraindication 13200003 DOID:750
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Asthenia contraindication 13791008
Hepatic encephalopathy contraindication 13920009 DOID:13413
Hyperkalemia contraindication 14140009
Severe chronic ulcerative colitis contraindication 14311001
Constipation contraindication 14760008 DOID:2089
Chronic disease of respiratory system contraindication 17097001
Mood swings contraindication 18963009
Pulmonary edema contraindication 19242006 DOID:11396
Cirrhosis of liver contraindication 19943007 DOID:5082
Myocardial infarction contraindication 22298006 DOID:5844
Glaucoma contraindication 23986001 DOID:1686
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Ventricular tachycardia contraindication 25569003
Alcohol intoxication contraindication 25702006
Shock contraindication 27942005
Toxic megacolon contraindication 28536002 DOID:1770
Atony of colon contraindication 29479008
Hypercapnia contraindication 29596007
Dehydration contraindication 34095006
Hyperthyroidism contraindication 34486009 DOID:7998
Depressive disorder contraindication 35489007
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Hypernatremia contraindication 39355002
Disorder of gallbladder contraindication 39621005 DOID:0060262
Hypothyroidism contraindication 40930008 DOID:1459
Complete trisomy 21 syndrome contraindication 41040004 DOID:14250
Alcoholic liver damage contraindication 41309000
Third trimester pregnancy contraindication 41587001
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Achalasia of esophagus contraindication 45564002 DOID:9164
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Acidosis contraindication 51387008
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Paralytic ileus contraindication 55525008 DOID:8442
Heart disease contraindication 56265001 DOID:114
Peptic reflux disease contraindication 57643001
Multiple organ failure contraindication 57653000
Acute nephropathy contraindication 58574008
Metabolic acidosis contraindication 59455009
Hepatic failure contraindication 59927004
Diarrhea contraindication 62315008
Ulcerative colitis contraindication 64766004 DOID:8577
Poisoning by phenobarbital contraindication 64921004
Arterial thrombosis contraindication 65198009
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Psychotic disorder contraindication 69322001
Poisoning by acetaminophen contraindication 70273001
Agoraphobia contraindication 70691001 DOID:593
Arteriosclerotic vascular disease contraindication 72092001
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Sleep apnea contraindication 73430006 DOID:0050847
Urethral stricture contraindication 76618002
Spastic paralysis contraindication 78403003
Disturbance of salivary secretion contraindication 78948009
Decreased respiratory function contraindication 80954004
Injury of head contraindication 82271004
Chronic idiopathic constipation contraindication 82934008
Oliguria contraindication 83128009
Cor pulmonale contraindication 83291003 DOID:8515
Hiatal hernia contraindication 84089009 DOID:12642
Epilepsy contraindication 84757009 DOID:1826
Pulmonary emphysema contraindication 87433001
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Acute abdominal pain contraindication 116290004
Procedure on urinary system contraindication 118677009
Gastrointestinal obstruction contraindication 126765001
Neoplasm of brain contraindication 126952004 DOID:1319
Seizure disorder contraindication 128613002
Autonomic dysreflexia contraindication 129618003
Bleeding contraindication 131148009
Cystic fibrosis contraindication 190905008 DOID:1485
Drug-induced psychosis contraindication 191483003 DOID:1742
Obsessive-compulsive disorder contraindication 191736004 DOID:10933
Insomnia contraindication 193462001
Angina pectoris contraindication 194828000
Partial atrioventricular block contraindication 195039008
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Myocardial dysfunction contraindication 233928007
Disease of liver contraindication 235856003 DOID:409
Hyporeninemic hypoaldosteronism contraindication 236464008
Bladder outflow obstruction contraindication 236645006
Morbid obesity contraindication 238136002 DOID:11981
Sepsis syndrome contraindication 238150007
Rhabdomyolysis contraindication 240131006
Pyloric obstruction contraindication 244815007
Benign prostatic hyperplasia contraindication 266569009
Dyspnea contraindication 267036007
Retention of urine contraindication 267064002
Anemia contraindication 271737000 DOID:2355
Continuous fever contraindication 271751000
Drowsy contraindication 271782001
Peripheral edema contraindication 271809000
Exacerbation of asthma contraindication 281239006
Pregnancy, function contraindication 289908002
Lesion of brain contraindication 301766008
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Familial hyperkalemic periodic paralysis contraindication 304737009 DOID:14451
Panic disorder contraindication 371631005 DOID:594
Coma contraindication 371632003
Primary adrenocortical insufficiency contraindication 373662000
Smoking cessation assistance contraindication 384742004
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Operation on gastrointestinal tract contraindication 386621005
Hypoxia contraindication 389086002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Pseudomembranous enterocolitis contraindication 397683000
Gastric ulcer contraindication 397825006 DOID:10808
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Chronic myocardial ischemia contraindication 413844008 DOID:3393
Disorder of coronary artery contraindication 414024009
Myocardial ischemia contraindication 414795007 DOID:3393
Traumatic injury contraindication 417746004
Myocardial infarction in recovery phase contraindication 418044006
Central nervous system depression contraindication 418072004
Porphyria contraindication 418470004
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant contraindication 422681000
Fever greater than 100.4 Fahrenheit contraindication 426000000
Dysfunction of sphincter of Oddi contraindication 430887001
Hypertensive urgency contraindication 443482000
Azotemia contraindication 445009001
Smokes tobacco daily contraindication 449868002
Severe dehydration contraindication 450316000
Acute exacerbation of asthma contraindication 708038006
Severe Hypoxemia contraindication
Theophylline Toxicity contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

ProductApplicantIngredients
Gecolate Summit Hill Laboratories 1
Gecolate, Glycodex Injection Summit Hill Laboratories 1
Guailaxin Zoetis Inc. 1
Guaifenesin Injection Elanco US Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
200MG/5ML;2.5MG/5ML OBREDON SOVEREIGN PHARMS N205474 Nov. 14, 2014 DISCN SOLUTION ORAL 10105324 Nov. 13, 2035 A METHOD OF INCREASING THE BIOAVAILABILITY OF GUAIFENESIN IN A SOLUTION CONTAINING 54% TO 66% BY WEIGHT OF PROPYLENE GLYCOL AND GLYCEROL, WHEREIN THE METHOD INCREASES THE CMAX BY AT LEAST 1.5 AND/OR INCREASES THE AUC (0-INF) BY AT LEAST 1.4
200MG/5ML;2.5MG/5ML OBREDON SOVEREIGN PHARMS N205474 Nov. 14, 2014 DISCN SOLUTION ORAL 9549907 Nov. 13, 2035 A METHOD OF INCREASING THE BIOAVAILABILITY OF GUAIFENESIN IN A SOLUTION CONTAINING 54% TO 66% BY WEIGHT OF PROPYLENE GLYCOL AND GLYCEROL, WHEREIN THE METHOD INCREASES THE CMAX BY AT LEAST 1.5 AND/OR INCREASES THE AUC (0-INF) BY AT LEAST 1.4
200MG/5ML;2.5MG/5ML OBREDON SOVEREIGN PHARMS N205474 Nov. 14, 2014 DISCN SOLUTION ORAL 9808431 Nov. 13, 2035 A METHOD OF INCREASING THE BIOAVAILABILITY OF GUAIFENESIN IN A SOLUTION CONTAINING 54% TO 66% BY WEIGHT OF PROPYLENE GLYCOL AND GLYCEROL, WHEREIN THE METHOD INCREASES THE CMAX BY AT LEAST 1.5 AND/OR INCREASES THE AUC (0-INF) BY AT LEAST 1.4

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018147 VUID
N0000146484 NUI
D00337 KEGG_DRUG
4018147 VANDF
C0018305 UMLSCUI
CHEBI:5551 CHEBI
CHEMBL980 ChEMBL_ID
DB00874 DRUGBANK_ID
D006140 MESH_DESCRIPTOR_UI
3516 PUBCHEM_CID
968 INN_ID
7617 IUPHAR_LIGAND_ID
495W7451VQ UNII
5032 RXNORM
2461 MMSL
4805 MMSL
d00797 MMSL
000724 NDDF
386184000 SNOMEDCT_US
87174009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Robitussin Elderberry Maximum Strength Cough plus Chest Congestion DM HUMAN OTC DRUG LABEL 2 0031-2097 SOLUTION 400 mg ORAL OTC monograph final 15 sections
Childrens Robitussin Elderberry Cough and Chest Congestion DM HUMAN OTC DRUG LABEL 2 0031-2098 SOLUTION 400 mg ORAL OTC monograph final 15 sections
Robitussin CF HUMAN OTC DRUG LABEL 3 0031-8678 LIQUID 100 mg ORAL Export only 15 sections
Childrens Robitussin Cough and Chest Congestion DM HUMAN OTC DRUG LABEL 2 0031-8702 LIQUID 200 mg ORAL OTC MONOGRAPH FINAL 15 sections
Childrens Robitussin Cough and Chest Congestion DM HUMAN OTC DRUG LABEL 2 0031-8715 LIQUID 100 mg ORAL OTC monograph final 15 sections
Childrens Robitussin Cough and Cold CF HUMAN OTC DRUG LABEL 3 0031-8716 LIQUID 50 mg ORAL OTC monograph final 16 sections
Robitussin Maximum Strength Cough Plus Chest Congestion DM HUMAN OTC DRUG LABEL 2 0031-8719 CAPSULE, LIQUID FILLED 200 mg ORAL OTC MONOGRAPH FINAL 15 sections
Robitussin Mucus Plus Chest Congestion HUMAN OTC DRUG LABEL 1 0031-8724 LIQUID 200 mg ORAL OTC MONOGRAPH FINAL 14 sections
ROBITUSSIN MAXIMUM STRENGTH COUGH PLUS CHEST CONGESTION DM HUMAN OTC DRUG LABEL 2 0031-8739 SOLUTION 400 mg ORAL OTC monograph final 15 sections
Robitussin Peak Cold Multi-Symptom Cold HUMAN OTC DRUG LABEL 3 0031-8742 LIQUID 100 mg ORAL OTC MONOGRAPH FINAL 17 sections
ROBITUSSIN CHEST CONGESTION HUMAN OTC DRUG LABEL 1 0031-8748 LIQUID 100 mg ORAL EXPORT ONLY 1 sections
Robitussin Severe Multi-Symptom Cough Cold Flu HUMAN OTC DRUG LABEL 4 0031-8751 LIQUID 400 mg ORAL OTC monograph final 17 sections
Robitussin Honey Maximum Strength Cough and Chest Congestion DM HUMAN OTC DRUG LABEL 2 0031-8756 SOLUTION 400 mg ORAL OTC monograph final 15 sections
ROBITUSSIN COUGH PLUS CHEST CONGESTION DM HUMAN OTC DRUG LABEL 2 0031-8757 SOLUTION 200 mg ORAL OTC monograph final 15 sections
Robitussin Sugar-Free Dye-Free Cough Plus Chest Congestion DM HUMAN OTC DRUG LABEL 2 0031-8759 SOLUTION 200 mg ORAL OTC monograph final 15 sections
Childrens Robitussin Honey Cough and Chest Congestion DM HUMAN OTC DRUG LABEL 2 0031-8760 SOLUTION 100 mg ORAL OTC MONOGRAPH FINAL 15 sections
Robitussin Maximum Strength 12 Hour Cough and Mucus Relief HUMAN OTC DRUG LABEL 2 0031-8765 TABLET, EXTENDED RELEASE 1200 mg ORAL ANDA 16 sections
TherafluCough Relief HUMAN OTC DRUG LABEL 2 0067-6089 POWDER, FOR SOLUTION 400 mg ORAL OTC monograph final 15 sections
Theraflu ExpressMax Severe Cold and Flu Syrup HUMAN OTC DRUG LABEL 4 0067-8132 SYRUP 400 mg ORAL OTC monograph final 16 sections
Theraflu ExpressMax Severe Cold and Flu Caplets HUMAN OTC DRUG LABEL 4 0067-8145 TABLET, COATED 200 mg ORAL OTC monograph final 16 sections
good sense tussinmucus and chest congestion HUMAN OTC DRUG LABEL 1 0113-0061 SOLUTION 200 mg ORAL OTC monograph final 13 sections
Good Sense Mucus ReliefCold and Sinus HUMAN OTC DRUG LABEL 3 0113-0145 TABLET, COATED 200 mg ORAL OTC monograph final 16 sections
good sense tussincf max HUMAN OTC DRUG LABEL 3 0113-0296 SOLUTION 400 mg ORAL OTC monograph final 15 sections
Good Sense Mucus ER HUMAN OTC DRUG LABEL 1 0113-0325 TABLET, EXTENDED RELEASE 1200 mg ORAL ANDA 14 sections
good sense tussin dm HUMAN OTC DRUG LABEL 2 0113-0359 SOLUTION 200 mg ORAL OTC monograph final 14 sections
Good Sense Mucus Reliefcold flu and sore throat HUMAN OTC DRUG LABEL 4 0113-0381 TABLET, FILM COATED 200 mg ORAL OTC monograph final 16 sections
Good Sense Childrens Mucus Relief Cough HUMAN OTC DRUG LABEL 2 0113-0419 SOLUTION 100 mg ORAL OTC monograph final 13 sections
Good Sense Severe DaytimeCold and Flu HUMAN OTC DRUG LABEL 4 0113-0548 TABLET, FILM COATED 200 mg ORAL OTC monograph final 16 sections
good sense tussin dmcough and chest congestion HUMAN OTC DRUG LABEL 2 0113-0578 SOLUTION 200 mg ORAL OTC monograph final 14 sections
good sense severe cold HUMAN OTC DRUG LABEL 4 0113-0579 TABLET, FILM COATED 200 mg ORAL OTC monograph final 16 sections