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cineole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4259 | 470-82-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A monoterpene and cyclohexanol derivative that is the major component of EUCALYPTUS OIL. It is used in mouthwash, insect repellent, and as a cough suppressant, and also is widely used as a flavoring agent and solvent. It has antimicrobial properties.
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAP3K21,MAPK7,NTRK2,PDK1,PDK2,PDK4,PRKDC,SIK2,STK33,TEK | 27 | |||
| kinase-selectivity-class | EIF2AK3,GRK2 | 2 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Dyspnoea | 42.65 | 27.98 | 36 | 423 | 442585 | 42178291 |
| Product prescribing error | 41.20 | 27.98 | 14 | 445 | 26098 | 42594778 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Product prescribing error | 45.48 | 24.34 | 17 | 944 | 51314 | 110537024 |
| Dyspnoea | 33.15 | 24.34 | 44 | 917 | 1106828 | 109481510 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | R05CA13 | RESPIRATORY SYSTEM COUGH AND COLD PREPARATIONS EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH SUPPRESSANTS Expectorants |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000996 | Antitussive Agents |
| MeSH PA | D003358 | Cosmetics |
| MeSH PA | D005421 | Flavoring Agents |
| MeSH PA | D005503 | Food Additives |
| MeSH PA | D007302 | Insect Repellents |
| MeSH PA | D009067 | Mouthwashes |
| MeSH PA | D010575 | Pesticides |
| MeSH PA | D010592 | Pharmaceutic Aids |
| MeSH PA | D012997 | Solvents |
| MeSH PA | D019141 | Respiratory System Agents |
| MeSH PA | D020011 | Protective Agents |
| CHEBI has role | CHEBI:27311 | volatile oil component |
| CHEBI has role | CHEBI:51177 | antitussive |
Related Drugs by ATC class:
R05CA Expectorants 7 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4019135 | VUID |
| N0000179082 | NUI |
| D04115 | KEGG_DRUG |
| 4019135 | VANDF |
| CHEBI:27961 | CHEBI |
| CHEMBL485259 | ChEMBL_ID |
| DB03852 | DRUGBANK_ID |
| 21116 | RXNORM |
| NOCODE | MMSL |
| 002583 | NDDF |
| 259119007 | SNOMEDCT_US |
| C0055738 | UMLSCUI |
| D000077591 | MESH_DESCRIPTOR_UI |
| CNL | PDB_CHEM_ID |
| 2758 | PUBCHEM_CID |
| 2464 | IUPHAR_LIGAND_ID |
| RV6J6604TK | UNII |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Antiseptic Mouth Rinse | HUMAN OTC DRUG LABEL | 4 | 0363-0072 | MOUTHWASH | 0.92 mg | ORAL | OTC Monograph Drug | 12 sections |
| Rinse | HUMAN OTC DRUG LABEL | 4 | 0363-0318 | MOUTHWASH | 0.92 mg | ORAL | OTC Monograph Drug | 14 sections |
| Antispetic | HUMAN OTC DRUG LABEL | 4 | 0363-0664 | MOUTHWASH | 0.92 mg | ORAL | OTC Monograph Drug | 13 sections |
| Tartar control plus | HUMAN OTC DRUG LABEL | 4 | 0363-0855 | MOUTHWASH | 0.92 mg | ORAL | OTC Monograph Drug | 13 sections |
| Antiseptic | HUMAN OTC DRUG LABEL | 4 | 0869-0072 | MOUTHWASH | 0.92 mg | ORAL | OTC Monograph Drug | 13 sections |
| Antispetic | HUMAN OTC DRUG LABEL | 4 | 0869-0664 | MOUTHWASH | 0.92 mg | ORAL | OTC Monograph Drug | 13 sections |
| Antispetic | HUMAN OTC DRUG LABEL | 4 | 10202-664 | MOUTHWASH | 0.92 mg | ORAL | OTC Monograph Drug | 12 sections |
| Antiseptic Mouth Rinse | HUMAN OTC DRUG LABEL | 4 | 11344-072 | MOUTHWASH | 0.92 mg | ORAL | OTC Monograph Drug | 14 sections |
| Antiseptic Mouth Rinse | HUMAN OTC DRUG LABEL | 4 | 11344-318 | MOUTHWASH | 0.92 mg | ORAL | OTC Monograph Drug | 14 sections |
| Antispetic | HUMAN OTC DRUG LABEL | 4 | 11344-664 | MOUTHWASH | 0.92 mg | ORAL | OTC Monograph Drug | 14 sections |
| Tartar control plus Antiseptic | HUMAN OTC DRUG LABEL | 4 | 11344-855 | MOUTHWASH | 0.92 mg | ORAL | OTC Monograph Drug | 13 sections |
| Antispetic | HUMAN OTC DRUG LABEL | 4 | 11673-072 | MOUTHWASH | 0.92 mg | ORAL | OTC Monograph Drug | 14 sections |
| Antiseptic | HUMAN OTC DRUG LABEL | 4 | 11673-318 | MOUTHWASH | 0.92 mg | ORAL | OTC Monograph Drug | 13 sections |
| Antispetic | HUMAN OTC DRUG LABEL | 4 | 11673-664 | MOUTHWASH | 0.92 mg | ORAL | OTC Monograph Drug | 15 sections |
| Antiseptic Mouth Rinse | HUMAN OTC DRUG LABEL | 4 | 11822-0072 | MOUTHWASH | 0.92 mg | ORAL | OTC Monograph Drug | 12 sections |
| Antispetic | HUMAN OTC DRUG LABEL | 4 | 11822-0664 | MOUTHWASH | 0.92 mg | ORAL | OTC Monograph Drug | 13 sections |
| Oral Care Antiseptic | HUMAN OTC DRUG LABEL | 4 | 11822-3108 | MOUTHWASH | 0.92 mg | ORAL | OTC Monograph Drug | 13 sections |
| Tartar control plus | HUMAN OTC DRUG LABEL | 4 | 11822-5829 | MOUTHWASH | 0.92 mg | ORAL | OTC Monograph Drug | 12 sections |
| Mastic Dent | HUMAN OTC DRUG LABEL | 4 | 15304-4085 | MOUTHWASH | 0.92 mg | ORAL | OTC monograph not final | 10 sections |
| Antispetic | HUMAN OTC DRUG LABEL | 4 | 21130-072 | MOUTHWASH | 0.92 mg | ORAL | OTC Monograph Drug | 13 sections |
| Antiseptic Mouth Rinse | HUMAN OTC DRUG LABEL | 4 | 21130-318 | MOUTHWASH | 0.92 mg | ORAL | OTC Monograph Drug | 13 sections |
| Antispetic | HUMAN OTC DRUG LABEL | 4 | 21130-664 | MOUTHWASH | 0.92 mg | ORAL | OTC Monograph Drug | 13 sections |
| Mouth Rinse | HUMAN OTC DRUG LABEL | 4 | 30142-072 | MOUTHWASH | 0.92 mg | ORAL | OTC Monograph Drug | 14 sections |
| Antiseptic Mouth Rinse | HUMAN OTC DRUG LABEL | 4 | 30142-318 | MOUTHWASH | 0.92 mg | ORAL | OTC Monograph Drug | 14 sections |
| Antispetic | HUMAN OTC DRUG LABEL | 4 | 30142-664 | MOUTHWASH | 0.92 mg | ORAL | OTC Monograph Drug | 12 sections |
| Tartar control plus | HUMAN OTC DRUG LABEL | 4 | 30142-855 | MOUTHWASH | 0.92 mg | ORAL | OTC Monograph Drug | 13 sections |
| Kroger Cool Mint Boost Mouth | HUMAN OTC DRUG LABEL | 4 | 30142-978 | RINSE | 0.92 mg | ORAL | OTC monograph not final | 11 sections |
| Antiseptic Mouth Rinse | HUMAN OTC DRUG LABEL | 4 | 36800-072 | MOUTHWASH | 0.92 mg | ORAL | OTC Monograph Drug | 15 sections |
| Original Antiseptic | HUMAN OTC DRUG LABEL | 4 | 36800-318 | MOUTHWASH | 0.92 mg | ORAL | OTC Monograph Drug | 14 sections |
| Antispetic | HUMAN OTC DRUG LABEL | 4 | 36800-664 | MOUTHWASH | 0.92 mg | ORAL | OTC Monograph Drug | 13 sections |