glycerol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1316 56-81-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • glycerol
  • glycerin
  • glycerine
  • propane-1,2,3-triol
  • 1,2,3-triglycerol
  • glycyl alcohol
A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, or sweetening agent.
  • Molecular weight: 92.09
  • Formula: C3H8O3
  • CLOGP: -1.54
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 3
  • TPSA: 60.69
  • ALOGS: 1.10
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
May 6, 1982 FDA B BRAUN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pneumonia aspiration 217.18 27.46 42 381 3700 2353962
Coma 180.18 27.46 42 381 9014 2348648
Gastrooesophageal reflux disease 174.68 27.46 41 382 9054 2348608
Eye irritation 158.42 27.46 32 391 3480 2354182
Somnolence 144.88 27.46 43 380 23442 2334220
Drug hypersensitivity 94.04 27.46 37 386 46606 2311056
Drug ineffective 80.70 27.46 42 381 101582 2256080
Eye discharge 50.96 27.46 10 413 913 2356749
Pruritus 46.07 27.46 22 401 43318 2314344
Foreign body sensation in eyes 44.89 27.46 8 415 432 2357230
Eye pain 43.45 27.46 12 411 4879 2352783
Ocular hyperaemia 40.91 27.46 11 412 4045 2353617
Eyelid oedema 40.55 27.46 10 413 2616 2355046
Menstruation delayed 39.27 27.46 7 416 378 2357284
Vision blurred 34.08 27.46 13 410 14655 2343007
Foetal alcohol syndrome 33.73 27.46 4 419 9 2357653
Weight decreased 28.82 27.46 14 409 28357 2329305

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 50.41 36.27 18 252 16294 1730217
Cerebrovascular accident 48.81 36.27 18 252 17848 1728663
Diabetic foot infection 46.20 36.27 7 263 129 1746382
Oedema peripheral 43.65 36.27 16 254 15534 1730977
Finger amputation 41.56 36.27 6 264 78 1746433
Ascites 41.33 36.27 12 258 5574 1740937
Drug reaction with eosinophilia and systemic symptoms 37.98 36.27 11 259 5059 1741452

Pharmacologic Action:

SourceCodeDescription
ATC A06AG04 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR CONSTIPATION
DRUGS FOR CONSTIPATION
Enemas
ATC A06AX01 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR CONSTIPATION
DRUGS FOR CONSTIPATION
Other drugs for constipation
CHEBI has role CHEBI:46787 solvent
CHEBI has role CHEBI:27780 detergent
FDA EPC N0000185370 Non-Standardized Chemical Allergen
FDA PE N0000175629 Increased Histamine Release
FDA PE N0000184306 Cell-mediated Immunity
FDA PE N0000185001 Increased IgG Production
FDA CS M0000728 Allergens
FDA CS M0009417 Glycerol
MeSH PA D003451 Cryoprotective Agents
MeSH PA D020011 Protective Agents
MeSH PA D012997 Solvents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Constipation indication 14760008 DOID:2089

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D005990 MESH_DESCRIPTOR_UI
4017411 VUID
N0000145799 NUI
C0017861 UMLSCUI
D00028 KEGG_DRUG
80582002 SNOMEDCT_US
404833002 SNOMEDCT_US
602 MMSL
4792 MMSL
d00652 MMSL
4017411 VANDF
52080 MMSL
108842 MMSL
4910 RXNORM
002240 NDDF
001176 NDDF
002469 NDDF
001893 NDDF
004085 NDDF
002291 NDDF
753 PUBCHEM_CID
CHEBI:17754 CHEBI
CHEMBL692 ChEMBL_ID
PDC6A3C0OX UNII
444 INN_ID
GOL PDB_CHEM_ID
DB09462 DRUGBANK_ID
5195 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
REFRESH OPTIVE HUMAN OTC DRUG LABEL 1 0023-3240 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC MONOGRAPH FINAL 8 sections
Refresh Optive HUMAN OTC DRUG LABEL 1 0023-3416 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC MONOGRAPH FINAL 9 sections
REFRESH OPTIVE Advanced HUMAN OTC DRUG LABEL 2 0023-4307 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC MONOGRAPH FINAL 10 sections
REFRESH OPTIVE Advanced HUMAN OTC DRUG LABEL 2 0023-4491 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC MONOGRAPH FINAL 9 sections
Refresh Repair HUMAN OTC DRUG LABEL 1 0023-4607 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC MONOGRAPH FINAL 8 sections
REFRESH OPTIVE Drops HUMAN OTC DRUG LABEL 1 0023-5459 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC MONOGRAPH FINAL 9 sections
REFRESH OPTIVE Mega-3 HUMAN OTC DRUG LABEL 2 0023-5773 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC MONOGRAPH FINAL 8 sections
Refresh Repair Preservative-free HUMAN OTC DRUG LABEL 1 0023-6465 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC MONOGRAPH FINAL 8 sections
Refresh Relieva HUMAN OTC DRUG LABEL 1 0023-6630 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC MONOGRAPH FINAL 8 sections
Refresh Relieva Preservative Free HUMAN OTC DRUG LABEL 1 0023-6634 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC MONOGRAPH FINAL 8 sections
Endura HUMAN PRESCRIPTION DRUG LABEL 2 0023-9235 SOLUTION/ DROPS 1 g OPHTHALMIC EXPORT ONLY 1 sections
GenTeal Tears (Moderate) HUMAN OTC DRUG LABEL 1 0065-0426 SOLUTION/ DROPS 2 mg OPHTHALMIC OTC monograph final 12 sections
Good Sense Hemorrhoidal HUMAN OTC DRUG LABEL 3 0113-0944 CREAM 14.40 g TOPICAL OTC monograph final 9 sections
Fleet HUMAN OTC DRUG LABEL 1 0132-0079 SUPPOSITORY 2 g RECTAL OTC monograph not final 9 sections
Fleet HUMAN OTC DRUG LABEL 1 0132-0185 LIQUID 5.40 g RECTAL OTC monograph not final 11 sections
Pedia-Lax HUMAN OTC DRUG LABEL 1 0132-0190 LIQUID 2.80 g RECTAL OTC monograph not final 10 sections
Pedia-Lax HUMAN OTC DRUG LABEL 1 0132-0195 LIQUID 2.80 g RECTAL OTC MONOGRAPH NOT FINAL 9 sections
ProcalAmine HUMAN PRESCRIPTION DRUG LABEL 22 0264-1915 INJECTION 3 g INTRAVENOUS NDA 13 sections
Chloraseptic Sore Throat Max HUMAN OTC DRUG LABEL 2 0295-1749 SPRAY 33 mg ORAL OTC monograph not final 8 sections
Walgreens Children Glycerin HUMAN OTC DRUG LABEL 1 0363-0440 SUPPOSITORY 83 g RECTAL OTC monograph not final 12 sections
Walgreens Adult Glycerin HUMAN OTC DRUG LABEL 1 0363-0445 SUPPOSITORY 83 g RECTAL OTC monograph not final 13 sections
Hemorrhoidal Cream HUMAN OTC DRUG LABEL 3 0363-0641 CREAM 14.40 g TOPICAL OTC monograph not final 15 sections
hemorrhoidal HUMAN OTC DRUG LABEL 3 0363-0944 CREAM 14.40 g TOPICAL OTC monograph final 9 sections
Walgreens Multi-Symptom Relief Eye Drops HUMAN OTC DRUG LABEL 4 0363-1462 SOLUTION/ DROPS 0.20 g OPHTHALMIC OTC monograph final 8 sections
WALGREENS MAXIMUM REDNESS RELIEF HUMAN OTC DRUG LABEL 2 0363-1465 SOLUTION 0.00 mg OPHTHALMIC OTC monograph final 12 sections
Walgreens Maximum Strength Hemorrhoidal HUMAN OTC DRUG LABEL 3 0363-1760 CREAM 0.14 mg TOPICAL OTC monograph final 12 sections
Walgreens Lubricant Eye HUMAN OTC DRUG LABEL 1 0363-1791 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC monograph final 9 sections
Walgreens Lubricant Eye HUMAN OTC DRUG LABEL 1 0363-1792 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC monograph final 9 sections
Walgreens Eye Drops Maximum Redness Relief 15mL HUMAN OTC DRUG LABEL 2 0363-4546 LIQUID 0.50 g OPHTHALMIC OTC monograph final 8 sections
Walgreens Redness Relief Eye Drops 15mL HUMAN OTC DRUG LABEL 2 0363-4548 LIQUID 0.25 g OPHTHALMIC OTC monograph final 9 sections