glycerol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	1316	56-81-5

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: glycerol glycerin glycerine propane-1,2,3-triol 1,2,3-triglycerol glycyl alcohol	A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, or sweetening agent. Molecular weight: 92.09 Formula: C3H8O3 CLOGP: -1.54 LIPINSKI: 0 HAC: 3 HDO: 3 TPSA: 60.69 ALOGS: 1.10 ROTB: 2

Molecule

Description

Molfile Inchi Smiles

Synonyms:

glycerol
glycerin
glycerine
propane-1,2,3-triol
1,2,3-triglycerol
glycyl alcohol

A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, or sweetening agent.

Molecular weight: 92.09
Formula: C3H8O3
CLOGP: -1.54
LIPINSKI: 0
HAC: 3
HDO: 3
TPSA: 60.69
ALOGS: 1.10
ROTB: 2

Drug dosage:

None

ADMET properties:

Property	Value	Reference
S (Water solubility)	500 mg/mL	Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Bocci G, Oprea TI, Benet LZ

Approvals:

Date	Agency	Company	Orphan
May 6, 1982	FDA	B BRAUN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Macular degeneration	858.86	16.54	273	11298	24103	63453348
Sedation complication	278.46	16.54	102	11469	13720	63463731
Creatinine renal clearance decreased	272.71	16.54	105	11466	16203	63461248
Blood calcium decreased	242.47	16.54	111	11460	26340	63451111
Constipation	209.21	16.54	230	11341	224713	63252738
Orthostatic hypotension	206.69	16.54	110	11461	36050	63441401
Chronic sinusitis	194.57	16.54	77	11494	12766	63464685
Sedation	188.46	16.54	106	11465	38703	63438748
Procedural pain	168.26	16.54	81	11490	21488	63455963
Paraesthesia oral	167.65	16.54	78	11493	19178	63458273
Cognitive disorder	160.11	16.54	109	11462	55706	63421745
Depressed level of consciousness	158.82	16.54	113	11458	61965	63415486
Balance disorder	124.13	16.54	111	11460	84311	63393140
Mobility decreased	89.05	16.54	110	11461	121049	63356402
Vaginal flatulence	87.99	16.54	30	11541	3263	63474188
Proctitis	73.32	16.54	30	11541	5411	63472040
Dyspepsia	67.48	16.54	88	11483	102108	63375343
Female genital tract fistula	66.94	16.54	31	11540	7528	63469923
Radiculopathy	63.09	16.54	31	11540	8580	63468871
Vaginal discharge	58.25	16.54	30	11541	9168	63468283
Superinfection	55.29	16.54	20	11551	2587	63474864
Drug ineffective	48.52	16.54	340	11231	1044425	62433026
Hypotension	45.98	16.54	131	11440	272473	63204978
Therapeutic product effect incomplete	44.65	16.54	81	11490	124975	63352476
Mouth swelling	43.72	16.54	20	11551	4720	63472731
Frequent bowel movements	41.37	16.54	34	11537	22988	63454463
Fall	39.10	16.54	158	11413	392176	63085275
Eye irritation	38.55	16.54	32	11539	21939	63455512
Weight decreased	37.30	16.54	123	11448	276675	63200776
Abdominal pain	36.55	16.54	127	11444	293329	63184122
Colitis ulcerative	35.72	16.54	33	11538	26058	63451393
Multiple drug therapy	35.58	16.54	16	11555	3630	63473821
Colitis	35.49	16.54	44	11527	48484	63428967
Oral candidiasis	35.49	16.54	31	11540	22767	63454684
Pain	34.17	16.54	241	11330	740387	62737064
Ejection fraction decreased	32.04	16.54	29	11542	22303	63455148
Haematochezia	29.10	16.54	42	11529	53502	63423949
Pustule	28.59	16.54	11	11560	1688	63475763
Pyrexia	28.36	16.54	164	11407	470314	63007137
Scleral hyperaemia	27.05	16.54	7	11564	292	63477159
Joint swelling	26.99	16.54	13	11558	327653	63149798
Maternal exposure during pregnancy	26.94	16.54	4	11567	220058	63257393
Toxicity to various agents	24.91	16.54	100	11471	247150	63230301
Therapeutic product effect decreased	24.87	16.54	3	11568	193184	63284267
Swelling	24.13	16.54	10	11561	275368	63202083
Blood phosphorus decreased	23.88	16.54	13	11558	4440	63473011
Synovitis	23.82	16.54	3	11568	186915	63290536
Nausea	23.50	16.54	248	11323	854223	62623228
Arthropathy	23.17	16.54	7	11564	234785	63242666
Rectal haemorrhage	23.13	16.54	36	11535	48994	63428457
Duodenal stenosis	22.93	16.54	7	11564	535	63476916
Glossodynia	22.48	16.54	3	11568	178873	63298578
Interstitial lung disease	21.94	16.54	40	11531	61868	63415583
Malaise	21.25	16.54	139	11432	415815	63061636
Peripheral swelling	21.22	16.54	11	11560	265931	63211520
Aphonia	20.50	16.54	16	11555	10047	63467404
Erythema	20.07	16.54	74	11497	175677	63301774
Abdominal pain lower	19.93	16.54	24	11547	25654	63451797
Instillation site pain	19.41	16.54	7	11564	897	63476554
Foreign body sensation in eyes	19.27	16.54	9	11562	2225	63475226
Discomfort	18.41	16.54	4	11567	167370	63310081
Condition aggravated	17.50	16.54	29	11542	402188	63075263
Dysphoria	17.38	16.54	11	11560	4955	63472496
Arthralgia	16.70	16.54	51	11520	569659	62907792
Drug intolerance	16.69	16.54	19	11552	308642	63168809
Hepatic enzyme increased	16.69	16.54	8	11563	202320	63275131

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Ocular procedural complication	74.93	16.33	12	4470	55	34952394
Volvulus	40.91	16.33	13	4469	1619	34950830
Pneumonia aspiration	36.06	16.33	35	4447	41868	34910581
Keratitis	34.08	16.33	11	4471	1440	34951009
Injection related reaction	33.43	16.33	8	4474	346	34952103
Finger amputation	27.33	16.33	6	4476	176	34952273
Diabetic foot infection	23.80	16.33	7	4475	672	34951777
Intestinal obstruction	19.50	16.33	19	4463	22803	34929646
Corneal epithelium defect	18.22	16.33	5	4477	374	34952075
Pneumonia	18.21	16.33	93	4389	362534	34589915
Skin reaction	17.70	16.33	10	4472	5220	34947229
Anal erosion	17.41	16.33	3	4479	23	34952426
Constipation	16.93	16.33	47	4435	136935	34815514

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Creatinine renal clearance decreased	285.25	14.60	112	13894	18890	79711492
Sedation complication	284.15	14.60	106	13900	15563	79714819
Blood calcium decreased	244.88	14.60	117	13889	31702	79698680
Constipation	219.78	14.60	259	13747	282791	79447591
Macular degeneration	195.97	14.60	74	13932	11222	79719160
Orthostatic hypotension	187.62	14.60	119	13887	56045	79674337
Chronic sinusitis	185.73	14.60	74	13932	12952	79717430
Sedation	173.45	14.60	110	13896	51785	79678597
Procedural pain	168.84	14.60	82	13924	23002	79707380
Paraesthesia oral	159.66	14.60	76	13930	20395	79709987
Cognitive disorder	152.66	14.60	114	13892	69812	79660570
Depressed level of consciousness	135.99	14.60	122	13884	96530	79633852
Balance disorder	127.78	14.60	119	13887	98738	79631644
Mobility decreased	104.93	14.60	118	13888	122057	79608325
Vaginal flatulence	92.14	14.60	29	13977	2546	79727836
Female genital tract fistula	71.67	14.60	30	13976	5945	79724437
Proctitis	69.54	14.60	30	13976	6402	79723980
Ocular procedural complication	68.00	14.60	16	13990	465	79729917
Dyspepsia	64.21	14.60	87	13919	108600	79621782
Radiculopathy	63.45	14.60	31	13975	8793	79721589
Vaginal discharge	62.14	14.60	29	13977	7434	79722948
Pain	46.75	14.60	245	13761	703557	79026825
Superinfection	43.78	14.60	20	13986	4882	79725500
Therapeutic product effect incomplete	43.22	14.60	84	13922	141561	79588821
Mouth swelling	39.77	14.60	20	13986	6031	79724351
Keratitis	39.76	14.60	18	13988	4304	79726078
Multiple drug therapy	37.56	14.60	17	13989	4061	79726321
Fall	35.98	14.60	175	13831	487454	79242928
Frequent bowel movements	35.14	14.60	34	13972	29505	79700877
Abdominal pain	32.53	14.60	145	13861	389424	79340958
Colitis ulcerative	32.27	14.60	35	13971	34707	79695675
Oral candidiasis	31.35	14.60	32	13974	29596	79700786
Eye irritation	30.81	14.60	27	13979	20654	79709728
Pustule	30.59	14.60	12	13994	2013	79728369
Volvulus	30.09	14.60	13	13993	2783	79727599
Hypotension	28.93	14.60	153	13853	440164	79290218
Intestinal obstruction	27.79	14.60	36	13970	42984	79687398
Diabetic foot infection	24.41	14.60	8	13998	799	79729583
Weight decreased	23.02	14.60	123	13883	355075	79375307
Injection related reaction	22.45	14.60	8	13998	1028	79729354
Ejection fraction decreased	22.43	14.60	29	13977	34548	79695834
Scleral hyperaemia	22.19	14.60	6	14000	308	79730074
Colitis	21.76	14.60	43	13963	73264	79657118
Erythema	21.62	14.60	87	13919	223203	79507179
Nausea	21.35	14.60	259	13747	956937	78773445
Infusion related reaction	20.95	14.60	88	13918	230149	79500233
Haematochezia	20.89	14.60	47	13959	87598	79642784
Pyrexia	20.88	14.60	196	13810	678513	79051869
Aphonia	20.68	14.60	16	13990	10296	79720086
Duodenal stenosis	20.61	14.60	7	13999	780	79729602
Joint swelling	20.06	14.60	13	13993	288633	79441749
Foreign body sensation in eyes	19.89	14.60	9	13997	2148	79728234
Abdominal pain lower	19.60	14.60	26	13980	31756	79698626
Blood phosphorus decreased	19.47	14.60	13	13993	6655	79723727
Peripheral swelling	18.93	14.60	12	13994	269605	79460777
Contraindicated product administered	18.03	14.60	3	14003	157535	79572847
Finger amputation	17.50	14.60	6	14000	688	79729694
Malaise	17.37	14.60	146	13860	489723	79240659
Corneal epithelium defect	17.29	14.60	6	14000	713	79729669
Instillation site pain	17.26	14.60	6	14000	717	79729665
Dysphoria	15.71	14.60	10	13996	4724	79725658
Arthropathy	15.26	14.60	6	14000	177105	79553277
Gastrostomy tube site complication	14.84	14.60	4	14002	203	79730179

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A06AG04	ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Enemas
ATC	A06AX01	ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Other drugs for constipation
FDA CS	M0000728	Allergens
FDA CS	M0009417	Glycerol
MeSH PA	D003451	Cryoprotective Agents
MeSH PA	D020011	Protective Agents
MeSH PA	D012997	Solvents
FDA PE	N0000175629	Increased Histamine Release
FDA PE	N0000184306	Cell-mediated Immunity
FDA PE	N0000185001	Increased IgG Production
FDA EPC	N0000185370	Non-Standardized Chemical Allergen
CHEBI has role	CHEBI:25728	osmolytes
CHEBI has role	CHEBI:27780	Detergents
CHEBI has role	CHEBI:46787	solvents
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:75772	S. cerevisiae metabolites
CHEBI has role	CHEBI:76971	Escherichia coli metabolites
CHEBI has role	CHEBI:77746	Homo sapiens metabolite
CHEBI has role	CHEBI:84735	algal metabolites
CHEBI has role	CHEBI:176497	geroprotectors

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Constipation	indication	14760008	DOID:2089

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4017411	VUID
N0000145799	NUI
D00028	KEGG_DRUG
4017411	VANDF
C0017861	UMLSCUI
CHEBI:17754	CHEBI
CRY	PDB_CHEM_ID
CHEMBL692	ChEMBL_ID
753	PUBCHEM_CID
DB09462	DRUGBANK_ID
D005990	MESH_DESCRIPTOR_UI
5195	IUPHAR_LIGAND_ID
4910	RXNORM
108842	MMSL
4792	MMSL
52080	MMSL
602	MMSL
d00652	MMSL
001176	NDDF
001893	NDDF
002240	NDDF
002291	NDDF
002469	NDDF
004085	NDDF
404833002	SNOMEDCT_US
80582002	SNOMEDCT_US
444	INN_ID
PDC6A3C0OX	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
REFRESH OPTIVE	HUMAN OTC DRUG LABEL	2	0023-3240	SOLUTION/ DROPS	9 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	10 sections
REFRESH OPTIVE	HUMAN OTC DRUG LABEL	2	0023-3240	SOLUTION/ DROPS	9 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	10 sections
Refresh Optive	HUMAN OTC DRUG LABEL	2	0023-3416	SOLUTION/ DROPS	9 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	11 sections
Refresh Optive	HUMAN OTC DRUG LABEL	2	0023-3416	SOLUTION/ DROPS	9 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	11 sections
REFRESH OPTIVE Advanced	HUMAN OTC DRUG LABEL	3	0023-4307	SOLUTION/ DROPS	10 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	12 sections
REFRESH OPTIVE Advanced	HUMAN OTC DRUG LABEL	3	0023-4307	SOLUTION/ DROPS	10 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	12 sections
REFRESH OPTIVE Advanced	HUMAN OTC DRUG LABEL	3	0023-4491	SOLUTION/ DROPS	10 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	11 sections
REFRESH OPTIVE Advanced	HUMAN OTC DRUG LABEL	3	0023-4491	SOLUTION/ DROPS	10 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	11 sections
Refresh RELIEVA PF	HUMAN OTC DRUG LABEL	2	0023-4515	SOLUTION/ DROPS	10 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	10 sections
Refresh RELIEVA PF	HUMAN OTC DRUG LABEL	2	0023-4515	SOLUTION/ DROPS	10 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	10 sections
Refresh Repair	HUMAN OTC DRUG LABEL	2	0023-4607	SOLUTION/ DROPS	9 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	10 sections
REFRESH OPTIVE Drops	HUMAN OTC DRUG LABEL	2	0023-5459	SOLUTION/ DROPS	9 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	11 sections
REFRESH OPTIVE Drops	HUMAN OTC DRUG LABEL	2	0023-5459	SOLUTION/ DROPS	9 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	11 sections
REFRESH OPTIVE Mega-3	HUMAN OTC DRUG LABEL	3	0023-5773	SOLUTION/ DROPS	10 mg	OPHTHALMIC	OTC monograph final	10 sections
REFRESH OPTIVE Mega-3	HUMAN OTC DRUG LABEL	3	0023-5773	SOLUTION/ DROPS	10 mg	OPHTHALMIC	OTC monograph final	10 sections
Refresh Repair Preservative-free	HUMAN OTC DRUG LABEL	2	0023-6465	SOLUTION/ DROPS	9 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	10 sections
Refresh Relieva	HUMAN OTC DRUG LABEL	2	0023-6630	SOLUTION/ DROPS	9 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	10 sections
Refresh Relieva	HUMAN OTC DRUG LABEL	2	0023-6630	SOLUTION/ DROPS	9 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	10 sections
Refresh Relieva Preservative Free	HUMAN OTC DRUG LABEL	2	0023-6634	SOLUTION/ DROPS	9 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	10 sections
Refresh Relieva Preservative Free	HUMAN OTC DRUG LABEL	2	0023-6634	SOLUTION/ DROPS	9 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	10 sections
Refresh Digital	HUMAN OTC DRUG LABEL	3	0023-6952	SOLUTION/ DROPS	10 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	11 sections
Refresh Digital	HUMAN OTC DRUG LABEL	3	0023-6952	SOLUTION/ DROPS	10 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	11 sections
Refresh Digital PF	HUMAN OTC DRUG LABEL	3	0023-6954	SOLUTION/ DROPS	10 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	10 sections
Refresh Digital PF	HUMAN OTC DRUG LABEL	3	0023-6954	SOLUTION/ DROPS	10 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	10 sections
REFRESH OPTIVE Mega-3	HUMAN OTC DRUG LABEL	3	0023-7151	SOLUTION/ DROPS	10 mg	OPHTHALMIC	OTC monograph final	10 sections
REFRESH OPTIVE Mega-3	HUMAN OTC DRUG LABEL	3	0023-7151	SOLUTION/ DROPS	10 mg	OPHTHALMIC	OTC monograph final	10 sections
Endura	HUMAN PRESCRIPTION DRUG LABEL	2	0023-9235	SOLUTION/ DROPS	1 g	OPHTHALMIC	Export only	1 sections
Endura	HUMAN PRESCRIPTION DRUG LABEL	2	0023-9235	SOLUTION/ DROPS	1 g	OPHTHALMIC	Export only	1 sections
Refresh RELIEVA PF	HUMAN OTC DRUG LABEL	2	0023-9537	SOLUTION/ DROPS	10 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	10 sections
Refresh RELIEVA PF	HUMAN OTC DRUG LABEL	2	0023-9537	SOLUTION/ DROPS	10 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	10 sections