glycerol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1316 56-81-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • glycerol
  • glycerin
  • glycerine
  • propane-1,2,3-triol
  • 1,2,3-triglycerol
  • glycyl alcohol
A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, or sweetening agent.
  • Molecular weight: 92.09
  • Formula: C3H8O3
  • CLOGP: -1.54
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 3
  • TPSA: 60.69
  • ALOGS: 1.10
  • ROTB: 2

Drug dosage:

None

ADMET properties:

PropertyValueReference
S (Water solubility) 500 mg/mL Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Bocci G, Oprea TI, Benet LZ

Approvals:

DateAgencyCompanyOrphan
May 6, 1982 FDA B BRAUN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 858.86 16.54 273 11298 24103 63453348
Sedation complication 278.46 16.54 102 11469 13720 63463731
Creatinine renal clearance decreased 272.71 16.54 105 11466 16203 63461248
Blood calcium decreased 242.47 16.54 111 11460 26340 63451111
Constipation 209.21 16.54 230 11341 224713 63252738
Orthostatic hypotension 206.69 16.54 110 11461 36050 63441401
Chronic sinusitis 194.57 16.54 77 11494 12766 63464685
Sedation 188.46 16.54 106 11465 38703 63438748
Procedural pain 168.26 16.54 81 11490 21488 63455963
Paraesthesia oral 167.65 16.54 78 11493 19178 63458273
Cognitive disorder 160.11 16.54 109 11462 55706 63421745
Depressed level of consciousness 158.82 16.54 113 11458 61965 63415486
Balance disorder 124.13 16.54 111 11460 84311 63393140
Mobility decreased 89.05 16.54 110 11461 121049 63356402
Vaginal flatulence 87.99 16.54 30 11541 3263 63474188
Proctitis 73.32 16.54 30 11541 5411 63472040
Dyspepsia 67.48 16.54 88 11483 102108 63375343
Female genital tract fistula 66.94 16.54 31 11540 7528 63469923
Radiculopathy 63.09 16.54 31 11540 8580 63468871
Vaginal discharge 58.25 16.54 30 11541 9168 63468283
Superinfection 55.29 16.54 20 11551 2587 63474864
Drug ineffective 48.52 16.54 340 11231 1044425 62433026
Hypotension 45.98 16.54 131 11440 272473 63204978
Therapeutic product effect incomplete 44.65 16.54 81 11490 124975 63352476
Mouth swelling 43.72 16.54 20 11551 4720 63472731
Frequent bowel movements 41.37 16.54 34 11537 22988 63454463
Fall 39.10 16.54 158 11413 392176 63085275
Eye irritation 38.55 16.54 32 11539 21939 63455512
Weight decreased 37.30 16.54 123 11448 276675 63200776
Abdominal pain 36.55 16.54 127 11444 293329 63184122
Colitis ulcerative 35.72 16.54 33 11538 26058 63451393
Multiple drug therapy 35.58 16.54 16 11555 3630 63473821
Colitis 35.49 16.54 44 11527 48484 63428967
Oral candidiasis 35.49 16.54 31 11540 22767 63454684
Pain 34.17 16.54 241 11330 740387 62737064
Ejection fraction decreased 32.04 16.54 29 11542 22303 63455148
Haematochezia 29.10 16.54 42 11529 53502 63423949
Pustule 28.59 16.54 11 11560 1688 63475763
Pyrexia 28.36 16.54 164 11407 470314 63007137
Scleral hyperaemia 27.05 16.54 7 11564 292 63477159
Joint swelling 26.99 16.54 13 11558 327653 63149798
Maternal exposure during pregnancy 26.94 16.54 4 11567 220058 63257393
Toxicity to various agents 24.91 16.54 100 11471 247150 63230301
Therapeutic product effect decreased 24.87 16.54 3 11568 193184 63284267
Swelling 24.13 16.54 10 11561 275368 63202083
Blood phosphorus decreased 23.88 16.54 13 11558 4440 63473011
Synovitis 23.82 16.54 3 11568 186915 63290536
Nausea 23.50 16.54 248 11323 854223 62623228
Arthropathy 23.17 16.54 7 11564 234785 63242666
Rectal haemorrhage 23.13 16.54 36 11535 48994 63428457
Duodenal stenosis 22.93 16.54 7 11564 535 63476916
Glossodynia 22.48 16.54 3 11568 178873 63298578
Interstitial lung disease 21.94 16.54 40 11531 61868 63415583
Malaise 21.25 16.54 139 11432 415815 63061636
Peripheral swelling 21.22 16.54 11 11560 265931 63211520
Aphonia 20.50 16.54 16 11555 10047 63467404
Erythema 20.07 16.54 74 11497 175677 63301774
Abdominal pain lower 19.93 16.54 24 11547 25654 63451797
Instillation site pain 19.41 16.54 7 11564 897 63476554
Foreign body sensation in eyes 19.27 16.54 9 11562 2225 63475226
Discomfort 18.41 16.54 4 11567 167370 63310081
Condition aggravated 17.50 16.54 29 11542 402188 63075263
Dysphoria 17.38 16.54 11 11560 4955 63472496
Arthralgia 16.70 16.54 51 11520 569659 62907792
Drug intolerance 16.69 16.54 19 11552 308642 63168809
Hepatic enzyme increased 16.69 16.54 8 11563 202320 63275131

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Ocular procedural complication 74.93 16.33 12 4470 55 34952394
Volvulus 40.91 16.33 13 4469 1619 34950830
Pneumonia aspiration 36.06 16.33 35 4447 41868 34910581
Keratitis 34.08 16.33 11 4471 1440 34951009
Injection related reaction 33.43 16.33 8 4474 346 34952103
Finger amputation 27.33 16.33 6 4476 176 34952273
Diabetic foot infection 23.80 16.33 7 4475 672 34951777
Intestinal obstruction 19.50 16.33 19 4463 22803 34929646
Corneal epithelium defect 18.22 16.33 5 4477 374 34952075
Pneumonia 18.21 16.33 93 4389 362534 34589915
Skin reaction 17.70 16.33 10 4472 5220 34947229
Anal erosion 17.41 16.33 3 4479 23 34952426
Constipation 16.93 16.33 47 4435 136935 34815514

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Creatinine renal clearance decreased 285.25 14.60 112 13894 18890 79711492
Sedation complication 284.15 14.60 106 13900 15563 79714819
Blood calcium decreased 244.88 14.60 117 13889 31702 79698680
Constipation 219.78 14.60 259 13747 282791 79447591
Macular degeneration 195.97 14.60 74 13932 11222 79719160
Orthostatic hypotension 187.62 14.60 119 13887 56045 79674337
Chronic sinusitis 185.73 14.60 74 13932 12952 79717430
Sedation 173.45 14.60 110 13896 51785 79678597
Procedural pain 168.84 14.60 82 13924 23002 79707380
Paraesthesia oral 159.66 14.60 76 13930 20395 79709987
Cognitive disorder 152.66 14.60 114 13892 69812 79660570
Depressed level of consciousness 135.99 14.60 122 13884 96530 79633852
Balance disorder 127.78 14.60 119 13887 98738 79631644
Mobility decreased 104.93 14.60 118 13888 122057 79608325
Vaginal flatulence 92.14 14.60 29 13977 2546 79727836
Female genital tract fistula 71.67 14.60 30 13976 5945 79724437
Proctitis 69.54 14.60 30 13976 6402 79723980
Ocular procedural complication 68.00 14.60 16 13990 465 79729917
Dyspepsia 64.21 14.60 87 13919 108600 79621782
Radiculopathy 63.45 14.60 31 13975 8793 79721589
Vaginal discharge 62.14 14.60 29 13977 7434 79722948
Pain 46.75 14.60 245 13761 703557 79026825
Superinfection 43.78 14.60 20 13986 4882 79725500
Therapeutic product effect incomplete 43.22 14.60 84 13922 141561 79588821
Mouth swelling 39.77 14.60 20 13986 6031 79724351
Keratitis 39.76 14.60 18 13988 4304 79726078
Multiple drug therapy 37.56 14.60 17 13989 4061 79726321
Fall 35.98 14.60 175 13831 487454 79242928
Frequent bowel movements 35.14 14.60 34 13972 29505 79700877
Abdominal pain 32.53 14.60 145 13861 389424 79340958
Colitis ulcerative 32.27 14.60 35 13971 34707 79695675
Oral candidiasis 31.35 14.60 32 13974 29596 79700786
Eye irritation 30.81 14.60 27 13979 20654 79709728
Pustule 30.59 14.60 12 13994 2013 79728369
Volvulus 30.09 14.60 13 13993 2783 79727599
Hypotension 28.93 14.60 153 13853 440164 79290218
Intestinal obstruction 27.79 14.60 36 13970 42984 79687398
Diabetic foot infection 24.41 14.60 8 13998 799 79729583
Weight decreased 23.02 14.60 123 13883 355075 79375307
Injection related reaction 22.45 14.60 8 13998 1028 79729354
Ejection fraction decreased 22.43 14.60 29 13977 34548 79695834
Scleral hyperaemia 22.19 14.60 6 14000 308 79730074
Colitis 21.76 14.60 43 13963 73264 79657118
Erythema 21.62 14.60 87 13919 223203 79507179
Nausea 21.35 14.60 259 13747 956937 78773445
Infusion related reaction 20.95 14.60 88 13918 230149 79500233
Haematochezia 20.89 14.60 47 13959 87598 79642784
Pyrexia 20.88 14.60 196 13810 678513 79051869
Aphonia 20.68 14.60 16 13990 10296 79720086
Duodenal stenosis 20.61 14.60 7 13999 780 79729602
Joint swelling 20.06 14.60 13 13993 288633 79441749
Foreign body sensation in eyes 19.89 14.60 9 13997 2148 79728234
Abdominal pain lower 19.60 14.60 26 13980 31756 79698626
Blood phosphorus decreased 19.47 14.60 13 13993 6655 79723727
Peripheral swelling 18.93 14.60 12 13994 269605 79460777
Contraindicated product administered 18.03 14.60 3 14003 157535 79572847
Finger amputation 17.50 14.60 6 14000 688 79729694
Malaise 17.37 14.60 146 13860 489723 79240659
Corneal epithelium defect 17.29 14.60 6 14000 713 79729669
Instillation site pain 17.26 14.60 6 14000 717 79729665
Dysphoria 15.71 14.60 10 13996 4724 79725658
Arthropathy 15.26 14.60 6 14000 177105 79553277
Gastrostomy tube site complication 14.84 14.60 4 14002 203 79730179

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A06AG04 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR CONSTIPATION
DRUGS FOR CONSTIPATION
Enemas
ATC A06AX01 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR CONSTIPATION
DRUGS FOR CONSTIPATION
Other drugs for constipation
FDA CS M0000728 Allergens
FDA CS M0009417 Glycerol
MeSH PA D003451 Cryoprotective Agents
MeSH PA D020011 Protective Agents
MeSH PA D012997 Solvents
FDA PE N0000175629 Increased Histamine Release
FDA PE N0000184306 Cell-mediated Immunity
FDA PE N0000185001 Increased IgG Production
FDA EPC N0000185370 Non-Standardized Chemical Allergen
CHEBI has role CHEBI:25728 osmolytes
CHEBI has role CHEBI:27780 Detergents
CHEBI has role CHEBI:46787 solvents
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:75772 S. cerevisiae metabolites
CHEBI has role CHEBI:76971 Escherichia coli metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:84735 algal metabolites
CHEBI has role CHEBI:176497 geroprotectors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Constipation indication 14760008 DOID:2089




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4017411 VUID
N0000145799 NUI
D00028 KEGG_DRUG
4017411 VANDF
C0017861 UMLSCUI
CHEBI:17754 CHEBI
CRY PDB_CHEM_ID
CHEMBL692 ChEMBL_ID
753 PUBCHEM_CID
DB09462 DRUGBANK_ID
D005990 MESH_DESCRIPTOR_UI
5195 IUPHAR_LIGAND_ID
4910 RXNORM
108842 MMSL
4792 MMSL
52080 MMSL
602 MMSL
d00652 MMSL
001176 NDDF
001893 NDDF
002240 NDDF
002291 NDDF
002469 NDDF
004085 NDDF
404833002 SNOMEDCT_US
80582002 SNOMEDCT_US
444 INN_ID
PDC6A3C0OX UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
REFRESH OPTIVE HUMAN OTC DRUG LABEL 2 0023-3240 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC MONOGRAPH FINAL 10 sections
REFRESH OPTIVE HUMAN OTC DRUG LABEL 2 0023-3240 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC MONOGRAPH FINAL 10 sections
Refresh Optive HUMAN OTC DRUG LABEL 2 0023-3416 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC MONOGRAPH FINAL 11 sections
Refresh Optive HUMAN OTC DRUG LABEL 2 0023-3416 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC MONOGRAPH FINAL 11 sections
REFRESH OPTIVE Advanced HUMAN OTC DRUG LABEL 3 0023-4307 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC MONOGRAPH FINAL 12 sections
REFRESH OPTIVE Advanced HUMAN OTC DRUG LABEL 3 0023-4307 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC MONOGRAPH FINAL 12 sections
REFRESH OPTIVE Advanced HUMAN OTC DRUG LABEL 3 0023-4491 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC MONOGRAPH FINAL 11 sections
REFRESH OPTIVE Advanced HUMAN OTC DRUG LABEL 3 0023-4491 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC MONOGRAPH FINAL 11 sections
Refresh RELIEVA PF HUMAN OTC DRUG LABEL 2 0023-4515 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC MONOGRAPH FINAL 10 sections
Refresh RELIEVA PF HUMAN OTC DRUG LABEL 2 0023-4515 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC MONOGRAPH FINAL 10 sections
Refresh Repair HUMAN OTC DRUG LABEL 2 0023-4607 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC MONOGRAPH FINAL 10 sections
REFRESH OPTIVE Drops HUMAN OTC DRUG LABEL 2 0023-5459 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC MONOGRAPH FINAL 11 sections
REFRESH OPTIVE Drops HUMAN OTC DRUG LABEL 2 0023-5459 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC MONOGRAPH FINAL 11 sections
REFRESH OPTIVE Mega-3 HUMAN OTC DRUG LABEL 3 0023-5773 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC monograph final 10 sections
REFRESH OPTIVE Mega-3 HUMAN OTC DRUG LABEL 3 0023-5773 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC monograph final 10 sections
Refresh Repair Preservative-free HUMAN OTC DRUG LABEL 2 0023-6465 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC MONOGRAPH FINAL 10 sections
Refresh Relieva HUMAN OTC DRUG LABEL 2 0023-6630 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC MONOGRAPH FINAL 10 sections
Refresh Relieva HUMAN OTC DRUG LABEL 2 0023-6630 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC MONOGRAPH FINAL 10 sections
Refresh Relieva Preservative Free HUMAN OTC DRUG LABEL 2 0023-6634 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC MONOGRAPH FINAL 10 sections
Refresh Relieva Preservative Free HUMAN OTC DRUG LABEL 2 0023-6634 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC MONOGRAPH FINAL 10 sections
Refresh Digital HUMAN OTC DRUG LABEL 3 0023-6952 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC MONOGRAPH FINAL 11 sections
Refresh Digital HUMAN OTC DRUG LABEL 3 0023-6952 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC MONOGRAPH FINAL 11 sections
Refresh Digital PF HUMAN OTC DRUG LABEL 3 0023-6954 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC MONOGRAPH FINAL 10 sections
Refresh Digital PF HUMAN OTC DRUG LABEL 3 0023-6954 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC MONOGRAPH FINAL 10 sections
REFRESH OPTIVE Mega-3 HUMAN OTC DRUG LABEL 3 0023-7151 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC monograph final 10 sections
REFRESH OPTIVE Mega-3 HUMAN OTC DRUG LABEL 3 0023-7151 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC monograph final 10 sections
Endura HUMAN PRESCRIPTION DRUG LABEL 2 0023-9235 SOLUTION/ DROPS 1 g OPHTHALMIC Export only 1 sections
Endura HUMAN PRESCRIPTION DRUG LABEL 2 0023-9235 SOLUTION/ DROPS 1 g OPHTHALMIC Export only 1 sections
Refresh RELIEVA PF HUMAN OTC DRUG LABEL 2 0023-9537 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC MONOGRAPH FINAL 10 sections
Refresh RELIEVA PF HUMAN OTC DRUG LABEL 2 0023-9537 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC MONOGRAPH FINAL 10 sections