glycerol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1316 56-81-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • glycerol
  • glycerin
  • glycerine
  • propane-1,2,3-triol
  • 1,2,3-triglycerol
  • glycyl alcohol
A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, or sweetening agent.
  • Molecular weight: 92.09
  • Formula: C3H8O3
  • CLOGP: -1.54
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 3
  • TPSA: 60.69
  • ALOGS: 1.10
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
May 6, 1982 FDA B BRAUN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 476.09 15.05 146 7276 14242 50583460
Sedation complication 119.98 15.05 46 7376 8720 50588982
Creatinine renal clearance decreased 113.05 15.05 48 7374 11833 50585869
Blood calcium decreased 101.76 15.05 53 7369 20653 50577049
Constipation 94.90 15.05 126 7296 185582 50412120
Orthostatic hypotension 84.31 15.05 53 7369 29428 50568274
Sedation 72.74 15.05 49 7373 30561 50567141
Depressed level of consciousness 65.49 15.05 57 7365 51896 50545806
Superinfection 64.22 15.05 20 7402 2036 50595666
Cognitive disorder 60.89 15.05 51 7371 44072 50553630
Mouth swelling 51.61 15.05 20 7402 3896 50593806
Eye irritation 46.95 15.05 30 7392 17110 50580592
Balance disorder 45.67 15.05 54 7368 70536 50527166
Ejection fraction decreased 42.44 15.05 29 7393 18491 50579211
Mobility decreased 37.29 15.05 52 7370 79896 50517806
Pustule 34.87 15.05 11 7411 1167 50596535
Scleral hyperaemia 29.32 15.05 7 7415 261 50597441
Abdominal pain lower 27.65 15.05 24 7398 21732 50575970
Duodenal stenosis 25.04 15.05 7 7415 489 50597213
Aphonia 23.61 15.05 15 7407 8463 50589239
Joint swelling 23.26 15.05 4 7418 245282 50352420
Foreign body sensation in eyes 22.98 15.05 9 7413 1802 50595900
Abdominal pain 21.73 15.05 80 7342 236148 50361554
Cellulitis 20.45 15.05 37 7385 70761 50526941
Drug ineffective 19.95 15.05 195 7227 819138 49778564
Swelling face 19.87 15.05 31 7391 52564 50545138
Interstitial lung disease 19.62 15.05 31 7391 53145 50544557
Procedural pain 19.09 15.05 16 7406 13816 50583886
Fall 18.28 15.05 97 7325 334835 50262867
Intestinal dilatation 17.59 15.05 7 7415 1461 50596241
Chronic sinusitis 17.43 15.05 11 7411 6134 50591568
Instillation site pain 17.34 15.05 6 7416 848 50596854
Keratitis 17.08 15.05 8 7414 2477 50595225
Periorbital swelling 15.93 15.05 7 7415 1870 50595832
Localised infection 15.65 15.05 19 7403 25466 50572236

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Ocular procedural complication 75.28 16.00 12 3727 54 29570734
Keratitis 36.18 16.00 11 3728 1201 29569587
Pneumonia aspiration 28.84 16.00 29 3710 36708 29534080
Finger amputation 27.75 16.00 6 3733 166 29570622
Diabetic foot infection 24.56 16.00 7 3732 610 29570178
Intestinal obstruction 20.46 16.00 18 3721 19259 29551529
Corneal epithelium defect 18.49 16.00 5 3734 359 29570429
Anal erosion 17.45 16.00 3 3736 23 29570765
Hepatic function abnormal 17.28 16.00 23 3716 39236 29531552

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Creatinine renal clearance decreased 122.50 14.60 54 9536 14367 64474775
Sedation complication 122.22 14.60 49 9541 10305 64478837
Blood calcium decreased 104.04 14.60 58 9532 25496 64463646
Constipation 102.56 14.60 147 9443 229190 64259952
Orthostatic hypotension 78.61 14.60 61 9529 46677 64442465
Ocular procedural complication 71.40 14.60 16 9574 443 64488699
Sedation 65.16 14.60 52 9538 41410 64447732
Cognitive disorder 59.96 14.60 56 9534 55031 64434111
Depressed level of consciousness 54.81 14.60 64 9526 81372 64407770
Superinfection 51.48 14.60 20 9570 3866 64485276
Balance disorder 46.82 14.60 60 9530 83866 64405276
Mouth swelling 46.20 14.60 20 9570 5087 64484055
Mobility decreased 44.20 14.60 59 9531 85781 64403361
Keratitis 44.09 14.60 17 9573 3220 64485922
Eye irritation 38.80 14.60 26 9564 15830 64473312
Pustule 37.17 14.60 12 9578 1353 64487789
Ejection fraction decreased 30.87 14.60 29 9561 28678 64460464
Abdominal pain lower 27.05 14.60 26 9564 26443 64462699
Diabetic foot infection 26.60 14.60 8 9582 714 64488428
Scleral hyperaemia 23.83 14.60 6 9584 276 64488866
Foreign body sensation in eyes 23.16 14.60 9 9581 1740 64487402
Aphonia 23.07 14.60 15 9575 8682 64480460
Duodenal stenosis 22.69 14.60 7 9583 681 64488461
Procedural pain 21.31 14.60 18 9572 15490 64473652
Finger amputation 18.98 14.60 6 9584 632 64488510
Urinary tract infection 18.69 14.60 76 9514 231520 64257622
Corneal epithelium defect 18.56 14.60 6 9584 679 64488463
Swelling face 18.15 14.60 32 9558 59134 64430008
Joint swelling 17.78 14.60 5 9585 215377 64273765
Alanine aminotransferase increased 17.63 14.60 53 9537 138978 64350164
Neutrophil count increased 17.27 14.60 20 9570 25154 64463988
Intestinal obstruction 17.23 14.60 24 9566 36262 64452880
Abdominal pain 16.75 14.60 91 9499 312284 64176858
Blood albumin decreased 16.61 14.60 18 9572 21055 64468087
Lymphocyte count decreased 16.54 14.60 25 9565 40674 64448468
Fall 16.38 14.60 112 9478 416714 64072428
Drug ineffective 16.36 14.60 67 9523 840180 63648962
Periorbital swelling 15.84 14.60 7 9583 1869 64487273
Macular degeneration 15.52 14.60 10 9580 5700 64483442
Corneal disorder 15.32 14.60 7 9583 2020 64487122
Cerebrovascular accident 15.19 14.60 50 9540 137533 64351609
Drug interaction 15.11 14.60 19 9571 362064 64127078
Instillation site pain 14.62 14.60 5 9585 674 64488468

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A06AG04 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR CONSTIPATION
DRUGS FOR CONSTIPATION
Enemas
ATC A06AX01 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR CONSTIPATION
DRUGS FOR CONSTIPATION
Other drugs for constipation
FDA CS M0000728 Allergens
FDA CS M0009417 Glycerol
MeSH PA D003451 Cryoprotective Agents
MeSH PA D020011 Protective Agents
MeSH PA D012997 Solvents
FDA PE N0000175629 Increased Histamine Release
FDA PE N0000184306 Cell-mediated Immunity
FDA PE N0000185001 Increased IgG Production
FDA EPC N0000185370 Non-Standardized Chemical Allergen
CHEBI has role CHEBI:25728 osmolytes
CHEBI has role CHEBI:27780 Detergents
CHEBI has role CHEBI:46787 solvents
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:75772 S. cerevisiae metabolites
CHEBI has role CHEBI:76971 Escherichia coli metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:84735 algal metabolites
CHEBI has role CHEBI:176497 geroprotectors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Constipation indication 14760008 DOID:2089




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4017411 VUID
N0000145799 NUI
D00028 KEGG_DRUG
4017411 VANDF
C0017861 UMLSCUI
CHEBI:17754 CHEBI
CRY PDB_CHEM_ID
CHEMBL692 ChEMBL_ID
753 PUBCHEM_CID
DB09462 DRUGBANK_ID
D005990 MESH_DESCRIPTOR_UI
5195 IUPHAR_LIGAND_ID
PDC6A3C0OX UNII
4910 RXNORM
108842 MMSL
4792 MMSL
52080 MMSL
602 MMSL
d00652 MMSL
001176 NDDF
001893 NDDF
002240 NDDF
002291 NDDF
002469 NDDF
004085 NDDF
404833002 SNOMEDCT_US
80582002 SNOMEDCT_US
444 INN_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
REFRESH OPTIVE HUMAN OTC DRUG LABEL 2 0023-3240 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC MONOGRAPH FINAL 10 sections
Refresh Optive HUMAN OTC DRUG LABEL 2 0023-3416 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC MONOGRAPH FINAL 11 sections
REFRESH OPTIVE Advanced HUMAN OTC DRUG LABEL 3 0023-4307 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC MONOGRAPH FINAL 12 sections
REFRESH OPTIVE Advanced HUMAN OTC DRUG LABEL 3 0023-4491 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC MONOGRAPH FINAL 11 sections
Refresh RELIEVA PF HUMAN OTC DRUG LABEL 2 0023-4515 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC MONOGRAPH FINAL 10 sections
Refresh Repair HUMAN OTC DRUG LABEL 2 0023-4607 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC MONOGRAPH FINAL 10 sections
REFRESH OPTIVE Drops HUMAN OTC DRUG LABEL 2 0023-5459 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC MONOGRAPH FINAL 11 sections
REFRESH OPTIVE Mega-3 HUMAN OTC DRUG LABEL 3 0023-5773 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC monograph final 10 sections
Refresh Repair Preservative-free HUMAN OTC DRUG LABEL 2 0023-6465 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC MONOGRAPH FINAL 10 sections
Refresh Relieva HUMAN OTC DRUG LABEL 2 0023-6630 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC MONOGRAPH FINAL 10 sections
Refresh Relieva Preservative Free HUMAN OTC DRUG LABEL 2 0023-6634 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC MONOGRAPH FINAL 10 sections
Refresh Relieva Preservative Free HUMAN OTC DRUG LABEL 2 0023-6634 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC MONOGRAPH FINAL 10 sections
Refresh Digital HUMAN OTC DRUG LABEL 3 0023-6952 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC MONOGRAPH FINAL 10 sections
Refresh Digital PF HUMAN OTC DRUG LABEL 3 0023-6954 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC MONOGRAPH FINAL 10 sections
REFRESH OPTIVE Mega-3 HUMAN OTC DRUG LABEL 3 0023-7151 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC monograph final 10 sections
Endura HUMAN PRESCRIPTION DRUG LABEL 2 0023-9235 SOLUTION/ DROPS 1 g OPHTHALMIC Export only 1 sections
Refresh RELIEVA PF HUMAN OTC DRUG LABEL 2 0023-9537 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC MONOGRAPH FINAL 10 sections
GenTeal Tears (Moderate) HUMAN OTC DRUG LABEL 3 0065-0426 SOLUTION/ DROPS 2 mg OPHTHALMIC OTC monograph final 13 sections
Good Sense HemorrhoidalMaximum Strength Pain Relief HUMAN OTC DRUG LABEL 4 0113-0944 CREAM 14.40 g TOPICAL OTC monograph final 15 sections
Fleet HUMAN OTC DRUG LABEL 1 0132-0075 SUPPOSITORY 2 g RECTAL OTC MONOGRAPH NOT FINAL 14 sections
Fleet HUMAN OTC DRUG LABEL 1 0132-0079 SUPPOSITORY 2 g RECTAL OTC MONOGRAPH NOT FINAL 12 sections
Fleet HUMAN OTC DRUG LABEL 1 0132-0079 SUPPOSITORY 2 g RECTAL OTC MONOGRAPH NOT FINAL 12 sections
Fleet HUMAN OTC DRUG LABEL 1 0132-0079 SUPPOSITORY 2 g RECTAL OTC MONOGRAPH NOT FINAL 12 sections
Fleet HUMAN OTC DRUG LABEL 1 0132-0079 SUPPOSITORY 2 g RECTAL OTC MONOGRAPH NOT FINAL 12 sections
Pedia-Lax HUMAN OTC DRUG LABEL 1 0132-0081 SUPPOSITORY 1 g RECTAL OTC MONOGRAPH NOT FINAL 11 sections
Fleet HUMAN OTC DRUG LABEL 1 0132-0185 LIQUID 5.40 g RECTAL OTC monograph not final 12 sections
Pedia-Lax HUMAN OTC DRUG LABEL 1 0132-0190 LIQUID 2.80 g RECTAL OTC monograph not final 11 sections
Pedia-Lax HUMAN OTC DRUG LABEL 1 0132-0195 LIQUID 2.80 g RECTAL OTC MONOGRAPH NOT FINAL 11 sections
ProcalAmine HUMAN PRESCRIPTION DRUG LABEL 22 0264-1915 INJECTION 3 g INTRAVENOUS NDA 24 sections
Walgreens Children GlycerinLaxative HUMAN OTC DRUG LABEL 1 0363-0440 SUPPOSITORY 83 g RECTAL OTC monograph not final 12 sections