glutethimide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1313 77-21-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • glutethimide
  • elrodorm
  • glutethimid
  • glimid
  • glutetimid
  • noxiron
  • noxyron
  • sarodormin
A hypnotic and sedative. Its use has been largely superseded by other drugs.
  • Molecular weight: 217.27
  • Formula: C13H15NO2
  • CLOGP: 1.99
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 46.17
  • ALOGS: -2.82
  • ROTB: 2

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.25 g O

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 38.34 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Oct. 28, 1976 FDA SANDOZ

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05CE01 NERVOUS SYSTEM
PSYCHOLEPTICS
HYPNOTICS AND SEDATIVES
Piperidinedione derivatives
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D006993 Hypnotics and Sedatives

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Insomnia indication 193462001
Hypochloremia contraindication 10399008
Hyperkalemia contraindication 14140009
Hyperbilirubinemia contraindication 14783006 DOID:2741
Infectious disease contraindication 40733004
Hypothyroidism contraindication 40930008 DOID:1459
Low blood pressure contraindication 45007003
Hyponatremia contraindication 89627008
Liver function tests abnormal contraindication 166603001
Disease of liver contraindication 235856003 DOID:409
Hypoglycemic disorder contraindication 237630007
Pregnancy, function contraindication 289908002
Surgical procedure contraindication 387713003
Traumatic injury contraindication 417746004

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.75 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor alpha-1/beta-3/gamma-2 Ion channel POSITIVE MODULATOR WOMBAT-PK CHEMBL

External reference:

IDSource
4018842 VUID
N0000147144 NUI
D00532 KEGG_DRUG
4018842 VANDF
C0017845 UMLSCUI
CHEBI:5439 CHEBI
CHEMBL1102 ChEMBL_ID
DB01437 DRUGBANK_ID
D005984 MESH_DESCRIPTOR_UI
3487 PUBCHEM_CID
7192 IUPHAR_LIGAND_ID
484 INN_ID
C8I4BVN78E UNII
4903 RXNORM
001432 NDDF
83143006 SNOMEDCT_US

Pharmaceutical products:

None