glutamic acid Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1310 56-86-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • glutamate
  • glutamic acid
  • L-Glutamic acid
  • glutaminic acid
  • glutaminol
  • glutamic acid hydrochloride
  • glutamic acid HCl
A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
  • Molecular weight: 147.13
  • Formula: C5H9NO4
  • CLOGP: -2.69
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 100.62
  • ALOGS: -0.26
  • ROTB: 4

Drug dosage:

DoseUnitRoute
1.50 g O

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 582.58 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC A09AB01 ALIMENTARY TRACT AND METABOLISM
DIGESTIVES, INCL. ENZYMES
DIGESTIVES, INCL. ENZYMES
Acid preparations

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Classical phenylketonuria contraindication 7573000
Poisoning by digitalis glycoside contraindication 12876009
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
End stage renal disease contraindication 46177005 DOID:784
Humoral hypercalcemia of malignancy contraindication 47709007
Heart disease contraindication 56265001 DOID:114
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Ventricular fibrillation contraindication 71908006
Hypercalciuria contraindication 71938000
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.97 acidic
pKa2 3.6 acidic
pKa3 10.35 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Metabotropic glutamate receptor 8 GPCR AGONIST IC50 5.70 IUPHAR
Metabotropic glutamate receptor 3 GPCR AGONIST Ki 7.40 IUPHAR
Glutamate dehydrogenase 1, mitochondrial Enzyme WOMBAT-PK
Glutamate dehydrogenase 2, mitochondrial Enzyme WOMBAT-PK
Glutamate receptor ionotropic, kainate 4 Ion channel Ki 7.74 PDSP
Glutamate receptor 3 Ion channel Ki 6.60 PDSP
Metabotropic glutamate receptor 7 GPCR EC50 5.93 CHEMBL
Excitatory amino acid transporter 3 Transporter Ki 7.29 CHEMBL
Metabotropic glutamate receptor 1 GPCR Ki 6.60 CHEMBL
Metabotropic glutamate receptor 2 GPCR EC50 6.54 CHEMBL
Metabotropic glutamate receptor 5 GPCR Ki 6.41 CHEMBL
Adenosine receptor A3 GPCR IC50 6.21 CHEMBL
Glutamate receptor ionotropic, kainate 1 Ion channel Ki 6.15 CHEMBL
Glutamate receptor ionotropic, kainate 5 Ion channel Ki 6.15 CHEMBL
Glutamate receptor ionotropic, kainate 3 Ion channel Ki 6.10 CHEMBL
Glutamate receptor 4 Ion channel Ki 6.06 CHEMBL
Glutamate receptor 2 Ion channel Ki 6.03 CHEMBL
Glutamate receptor ionotropic, kainate 2 Ion channel Ki 5.96 CHEMBL
Glutamate receptor 1 Ion channel Ki 5.87 CHEMBL
Metabotropic glutamate receptor 4 GPCR Ki 5.85 CHEMBL
Metabotropic glutamate receptor 6 GPCR EC50 5.31 CHEMBL
Excitatory amino acid transporter 1 Transporter Ki 4.46 CHEMBL
Glutathione reductase, mitochondrial Enzyme Ki 4.37 CHEMBL
Excitatory amino acid transporter 2 Transporter Ki 4.21 CHEMBL
Glutamate receptor 1 Ion channel EC50 4.46 CHEMBL
Glutamate receptor 2 Ion channel Ki 6.55 CHEMBL
Glutamate receptor 3 Ion channel EC50 4 CHEMBL
Glutamate receptor 4 Ion channel EC50 4.77 CHEMBL
Glutamate receptor ionotropic, kainate 1 Ion channel Ki 6.85 CHEMBL
Metabotropic glutamate receptor 1 Unclassified EC50 5 CHEMBL
Metabotropic glutamate receptor 2 Unclassified EC50 5.40 CHEMBL
Metabotropic glutamate receptor 3 Unclassified EC50 5.52 CHEMBL
Metabotropic glutamate receptor 4 GPCR EC50 4.92 CHEMBL
Metabotropic glutamate receptor 5 Unclassified EC50 5.36 CHEMBL
Metabotropic glutamate receptor 6 GPCR EC50 4.80 CHEMBL
Glutamate receptor ionotropic, NMDA 1 Ion channel EC50 5.54 CHEMBL
Glutamate receptor ionotropic, kainate 2 Ion channel Ki 5.48 CHEMBL
Glutamate receptor ionotropic, kainate 3 Ion channel Ki 6.31 CHEMBL
Metabotropic glutamate receptor 8 Unclassified EC50 7.66 CHEMBL
Metabotropic glutamate receptor 8 Unclassified Ki 5.47 CHEMBL
Glutamate racemase Unclassified Ki 4.55 CHEMBL
Glutamate racemase Unclassified Ki 5.24 CHEMBL

External reference:

IDSource
C0220839 UMLSCUI
D00007 KEGG_DRUG
3KX376GY7L UNII
66 INN_ID
42271003 SNOMEDCT_US
85214009 SNOMEDCT_US
4018681 VANDF
NOCODE MMSL
4823 MMSL
25916 RXNORM
4788 MMSL
d00487 MMSL
7086 MMSL
010581 NDDF
001113 NDDF
33032 PUBCHEM_CID
CHEBI:18237 CHEBI
CHEMBL76232 ChEMBL_ID
DB00142 DRUGBANK_ID
CHEMBL575060 ChEMBL_ID
138-15-8 SECONDARY_CAS_RN
GGL PDB_CHEM_ID
CHEMBL1255943 ChEMBL_ID
D018698 MESH_DESCRIPTOR_UI
1369 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Plenamine HUMAN PRESCRIPTION DRUG LABEL 17 0264-3200 SOLUTION 749 mg INTRAVENOUS ANDA 13 sections
Plenamine HUMAN PRESCRIPTION DRUG LABEL 17 0264-3205 SOLUTION 749 mg INTRAVENOUS ANDA 13 sections
Plenamine HUMAN PRESCRIPTION DRUG LABEL 17 0264-4500 SOLUTION 749 mg INTRAVENOUS ANDA 13 sections
TrophAmine HUMAN PRESCRIPTION DRUG LABEL 20 0264-9341 SOLUTION 0.50 g INTRAVENOUS NDA 12 sections
TrophAmine HUMAN PRESCRIPTION DRUG LABEL 20 0264-9361 SOLUTION 0.30 g INTRAVENOUS NDA 12 sections
ProSol HUMAN PRESCRIPTION DRUG LABEL 17 0338-0499 INJECTION, SOLUTION 1.02 g INTRAVENOUS NDA 15 sections
Clinisol HUMAN PRESCRIPTION DRUG LABEL 17 0338-0502 INJECTION, SOLUTION 749 mg INTRAVENOUS ANDA 11 sections
Premasol - sulfite-free (Amino Acid) HUMAN PRESCRIPTION DRUG LABEL 19 0338-1130 INJECTION, SOLUTION 0.50 g INTRAVENOUS ANDA 12 sections
Premasol - sulfite-free (Amino Acid) HUMAN PRESCRIPTION DRUG LABEL 19 0338-1131 INJECTION, SOLUTION 0.30 g INTRAVENOUS ANDA 12 sections
Aminosyn-PF HUMAN PRESCRIPTION DRUG LABEL 18 0409-4178 INJECTION, SOLUTION 576 mg INTRAVENOUS NDA 12 sections
Aminosyn-PF HUMAN PRESCRIPTION DRUG LABEL 18 0409-4179 INJECTION, SOLUTION 820 mg INTRAVENOUS NDA 12 sections
Aminosyn II HUMAN PRESCRIPTION DRUG LABEL 17 0409-7171 INJECTION, SOLUTION 1107 mg INTRAVENOUS NDA 13 sections
Aminosyn II HUMAN PRESCRIPTION DRUG LABEL 17 0409-7172 INJECTION, SOLUTION 738 mg INTRAVENOUS NDA 13 sections
Aminosyn-PF HUMAN PRESCRIPTION DRUG LABEL 18 0990-4179 INJECTION, SOLUTION 820 mg INTRAVENOUS NDA 12 sections
Aminosyn II HUMAN PRESCRIPTION DRUG LABEL 17 0990-7171 INJECTION, SOLUTION 1107 mg INTRAVENOUS NDA 13 sections
Aminosyn II HUMAN PRESCRIPTION DRUG LABEL 17 0990-7172 INJECTION, SOLUTION 738 mg INTRAVENOUS NDA 13 sections
Kabiven HUMAN PRESCRIPTION DRUG LABEL 22 63323-712 INJECTION, EMULSION 164 mg INTRAVENOUS NDA 18 sections
Perikabiven HUMAN PRESCRIPTION DRUG LABEL 22 63323-714 INJECTION, EMULSION 116 mg INTRAVENOUS NDA 18 sections
Women Secret Care HUMAN OTC DRUG LABEL 1 72530-102 GEL 1.74 g TOPICAL unapproved drug other 8 sections
Viatrexx-Neuro 3 HUMAN PRESCRIPTION DRUG LABEL 15 73069-373 INJECTION 201 [kp_C] INTRAVENOUS unapproved drug other 11 sections