glutamic acid Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	1310	56-86-0

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: glutamate glutamic acid L-Glutamic acid glutaminic acid glutaminol glutamic acid hydrochloride glutamic acid HCl	A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM. Molecular weight: 147.13 Formula: C5H9NO4 CLOGP: -2.69 LIPINSKI: 0 HAC: 5 HDO: 3 TPSA: 100.62 ALOGS: -0.26 ROTB: 4

Drug dosage:

Dose	Unit	Route
1.50	g	O

ADMET properties:

Property	Value	Reference
MRTD (Maximum Recommended Therapeutic Daily Dose)	582.58 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

Source	Code	Description
ATC	A09AB01	ALIMENTARY TRACT AND METABOLISM DIGESTIVES, INCL. ENZYMES DIGESTIVES, INCL. ENZYMES Acid preparations

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Classical phenylketonuria	contraindication	7573000
Poisoning by digitalis glycoside	contraindication	12876009
Sarcoidosis	contraindication	31541009	DOID:11335
Dehydration	contraindication	34095006
End stage renal disease	contraindication	46177005	DOID:784
Humoral hypercalcemia of malignancy	contraindication	47709007
Heart disease	contraindication	56265001	DOID:114
Hypercalcemia	contraindication	66931009	DOID:12678
Hyperparathyroidism	contraindication	66999008	DOID:13543
Ventricular fibrillation	contraindication	71908006
Hypercalciuria	contraindication	71938000
Kidney disease	contraindication	90708001	DOID:557
Kidney stone	contraindication	95570007

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	2.97	acidic
pKa2	3.6	acidic
pKa3	10.35	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Metabotropic glutamate receptor 8	GPCR	O00222	GRM8_HUMAN	AGONIST	IC50	5.70		IUPHAR
Metabotropic glutamate receptor 3	GPCR	Q14832	GRM3_HUMAN	AGONIST	Ki	7.40		IUPHAR
Glutamate dehydrogenase 1, mitochondrial	Enzyme	P00367	DHE3_HUMAN					WOMBAT-PK
Glutamate dehydrogenase 2, mitochondrial	Enzyme	P49448	DHE4_HUMAN					WOMBAT-PK
Glutamate receptor ionotropic, kainate 4	Ion channel	Q16099	GRIK4_HUMAN		Ki	7.74		PDSP
Glutamate receptor 3	Ion channel	P42263	GRIA3_HUMAN		Ki	6.60		PDSP
Metabotropic glutamate receptor 7	GPCR	Q14831	GRM7_HUMAN		EC50	5.93		CHEMBL
Excitatory amino acid transporter 3	Transporter	P43005	EAA3_HUMAN		Ki	7.29		CHEMBL
Metabotropic glutamate receptor 1	GPCR	Q13255	GRM1_HUMAN		Ki	6.60		CHEMBL
Metabotropic glutamate receptor 2	GPCR	Q14416	GRM2_HUMAN		EC50	6.54		CHEMBL
Metabotropic glutamate receptor 5	GPCR	P41594	GRM5_HUMAN		Ki	6.41		CHEMBL
Adenosine receptor A3	GPCR	P0DMS8	AA3R_HUMAN		IC50	6.21		CHEMBL
Glutamate receptor ionotropic, kainate 1	Ion channel	P39086	GRIK1_HUMAN		Ki	6.15		CHEMBL
Glutamate receptor ionotropic, kainate 5	Ion channel	Q16478	GRIK5_HUMAN		Ki	6.15		CHEMBL
Glutamate receptor ionotropic, kainate 3	Ion channel	Q13003	GRIK3_HUMAN		Ki	6.10		CHEMBL
Glutamate receptor 4	Ion channel	P48058	GRIA4_HUMAN		Ki	6.06		CHEMBL
Glutamate receptor 2	Ion channel	P42262	GRIA2_HUMAN		Ki	6.03		CHEMBL
Glutamate receptor ionotropic, kainate 2	Ion channel	Q13002	GRIK2_HUMAN		Ki	5.96		CHEMBL
Glutamate receptor 1	Ion channel	P42261	GRIA1_HUMAN		Ki	5.87		CHEMBL
Metabotropic glutamate receptor 4	GPCR	Q14833	GRM4_HUMAN		Ki	5.85		CHEMBL
Metabotropic glutamate receptor 6	GPCR	O15303	GRM6_HUMAN		EC50	5.31		CHEMBL
Excitatory amino acid transporter 1	Transporter	P43003	EAA1_HUMAN		Ki	4.46		CHEMBL
Glutathione reductase, mitochondrial	Enzyme	P00390	GSHR_HUMAN		Ki	4.37		CHEMBL
Excitatory amino acid transporter 2	Transporter	P43004	EAA2_HUMAN		Ki	4.21		CHEMBL
Glutamate receptor 1	Ion channel		GRIA1_RAT		EC50	4.46		CHEMBL
Glutamate receptor 2	Ion channel		GRIA2_RAT		Ki	6.55		CHEMBL
Glutamate receptor 3	Ion channel		GRIA3_RAT		EC50	4		CHEMBL
Glutamate receptor 4	Ion channel		GRIA4_RAT		EC50	4.77		CHEMBL
Glutamate receptor ionotropic, kainate 1	Ion channel		GRIK1_RAT		Ki	6.85		CHEMBL
Metabotropic glutamate receptor 1	Unclassified		GRM1_RAT		EC50	5		CHEMBL
Metabotropic glutamate receptor 2	Unclassified		GRM2_RAT		EC50	5.40		CHEMBL
Metabotropic glutamate receptor 3	Unclassified		GRM3_RAT		EC50	5.52		CHEMBL
Metabotropic glutamate receptor 4	GPCR		GRM4_RAT		EC50	4.92		CHEMBL
Metabotropic glutamate receptor 5	Unclassified		GRM5_RAT		EC50	5.36		CHEMBL
Metabotropic glutamate receptor 6	GPCR		GRM6_RAT		EC50	4.80		CHEMBL
Glutamate receptor ionotropic, NMDA 1	Ion channel		NMDZ1_RAT		EC50	5.54		CHEMBL
Glutamate receptor ionotropic, kainate 2	Ion channel		GRIK2_RAT		Ki	5.48		CHEMBL
Glutamate receptor ionotropic, kainate 3	Ion channel		GRIK3_RAT		Ki	6.31		CHEMBL
Metabotropic glutamate receptor 8	Unclassified		GRM8_MOUSE		EC50	7.66		CHEMBL
Metabotropic glutamate receptor 8	Unclassified		GRM8_RAT		Ki	5.47		CHEMBL
Glutamate racemase	Unclassified		MURI_LACFE		Ki	4.55		CHEMBL
Glutamate racemase	Unclassified		MURI_HELPY		Ki	5.24		CHEMBL

External reference:

ID	Source
C0220839	UMLSCUI
D00007	KEGG_DRUG
3KX376GY7L	UNII
66	INN_ID
42271003	SNOMEDCT_US
85214009	SNOMEDCT_US
4018681	VANDF
NOCODE	MMSL
4823	MMSL
25916	RXNORM
4788	MMSL
d00487	MMSL
7086	MMSL
010581	NDDF
001113	NDDF
33032	PUBCHEM_CID
CHEBI:18237	CHEBI
CHEMBL76232	ChEMBL_ID
DB00142	DRUGBANK_ID
CHEMBL575060	ChEMBL_ID
138-15-8	SECONDARY_CAS_RN
GGL	PDB_CHEM_ID
CHEMBL1255943	ChEMBL_ID
D018698	MESH_DESCRIPTOR_UI
1369	IUPHAR_LIGAND_ID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Plenamine	HUMAN PRESCRIPTION DRUG LABEL	17	0264-3200	SOLUTION	749 mg	INTRAVENOUS	ANDA	13 sections
Plenamine	HUMAN PRESCRIPTION DRUG LABEL	17	0264-3205	SOLUTION	749 mg	INTRAVENOUS	ANDA	13 sections
Plenamine	HUMAN PRESCRIPTION DRUG LABEL	17	0264-4500	SOLUTION	749 mg	INTRAVENOUS	ANDA	13 sections
TrophAmine	HUMAN PRESCRIPTION DRUG LABEL	20	0264-9341	SOLUTION	0.50 g	INTRAVENOUS	NDA	12 sections
TrophAmine	HUMAN PRESCRIPTION DRUG LABEL	20	0264-9361	SOLUTION	0.30 g	INTRAVENOUS	NDA	12 sections
ProSol	HUMAN PRESCRIPTION DRUG LABEL	17	0338-0499	INJECTION, SOLUTION	1.02 g	INTRAVENOUS	NDA	15 sections
Clinisol	HUMAN PRESCRIPTION DRUG LABEL	17	0338-0502	INJECTION, SOLUTION	749 mg	INTRAVENOUS	ANDA	11 sections
Premasol - sulfite-free (Amino Acid)	HUMAN PRESCRIPTION DRUG LABEL	19	0338-1130	INJECTION, SOLUTION	0.50 g	INTRAVENOUS	ANDA	12 sections
Premasol - sulfite-free (Amino Acid)	HUMAN PRESCRIPTION DRUG LABEL	19	0338-1131	INJECTION, SOLUTION	0.30 g	INTRAVENOUS	ANDA	12 sections
Aminosyn-PF	HUMAN PRESCRIPTION DRUG LABEL	18	0409-4178	INJECTION, SOLUTION	576 mg	INTRAVENOUS	NDA	12 sections
Aminosyn-PF	HUMAN PRESCRIPTION DRUG LABEL	18	0409-4179	INJECTION, SOLUTION	820 mg	INTRAVENOUS	NDA	12 sections
Aminosyn II	HUMAN PRESCRIPTION DRUG LABEL	17	0409-7171	INJECTION, SOLUTION	1107 mg	INTRAVENOUS	NDA	13 sections
Aminosyn II	HUMAN PRESCRIPTION DRUG LABEL	17	0409-7172	INJECTION, SOLUTION	738 mg	INTRAVENOUS	NDA	13 sections
Aminosyn-PF	HUMAN PRESCRIPTION DRUG LABEL	18	0990-4179	INJECTION, SOLUTION	820 mg	INTRAVENOUS	NDA	12 sections
Aminosyn II	HUMAN PRESCRIPTION DRUG LABEL	17	0990-7171	INJECTION, SOLUTION	1107 mg	INTRAVENOUS	NDA	13 sections
Aminosyn II	HUMAN PRESCRIPTION DRUG LABEL	17	0990-7172	INJECTION, SOLUTION	738 mg	INTRAVENOUS	NDA	13 sections
Kabiven	HUMAN PRESCRIPTION DRUG LABEL	22	63323-712	INJECTION, EMULSION	164 mg	INTRAVENOUS	NDA	18 sections
Perikabiven	HUMAN PRESCRIPTION DRUG LABEL	22	63323-714	INJECTION, EMULSION	116 mg	INTRAVENOUS	NDA	18 sections
Women Secret Care	HUMAN OTC DRUG LABEL	1	72530-102	GEL	1.74 g	TOPICAL	unapproved drug other	8 sections
Viatrexx-Neuro 3	HUMAN PRESCRIPTION DRUG LABEL	15	73069-373	INJECTION	201 [kp_C]	INTRAVENOUS	unapproved drug other	11 sections