glutamic acid Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1310 56-86-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • glutamate
  • glutamic acid
  • L-Glutamic acid
  • glutaminic acid
  • glutaminol
  • glutamic acid hydrochloride
  • glutamic acid HCl
A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
  • Molecular weight: 147.13
  • Formula: C5H9NO4
  • CLOGP: -2.69
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 100.62
  • ALOGS: -0.26
  • ROTB: 4

Drug dosage:

DoseUnitRoute
1.50 g O

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 582.58 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Foetal growth restriction 73.07 42.69 15 294 6552 46679201
Infantile apnoea 50.92 42.69 8 301 768 46684985
Selective eating disorder 44.44 42.69 8 301 1737 46684016

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

SourceCodeDescription
ATC A09AB01 ALIMENTARY TRACT AND METABOLISM
DIGESTIVES, INCL. ENZYMES
DIGESTIVES, INCL. ENZYMES
Acid preparations
CHEBI has role CHEBI:78675 essential metabolite
CHEBI has role CHEBI:25512 neurotransmitters
CHEBI has role CHEBI:27027 trace elements
CHEBI has role CHEBI:50733 nutritional supplement
CHEBI has role CHEBI:75771 mus musculus metabolite
CHEBI has role CHEBI:76971 e.coli metabolites
CHEBI has role CHEBI:173085 ferroptosis inducers

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Classical phenylketonuria contraindication 7573000
Poisoning by digitalis glycoside contraindication 12876009
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
End stage renal disease contraindication 46177005 DOID:784
Humoral hypercalcemia of malignancy contraindication 47709007
Heart disease contraindication 56265001 DOID:114
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Ventricular fibrillation contraindication 71908006
Hypercalciuria contraindication 71938000
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.97 acidic
pKa2 3.6 acidic
pKa3 10.35 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Metabotropic glutamate receptor 8 GPCR AGONIST IC50 5.70 IUPHAR
Metabotropic glutamate receptor 3 GPCR AGONIST Ki 7.40 IUPHAR
Glutamate dehydrogenase 2, mitochondrial Enzyme WOMBAT-PK
Glutamate dehydrogenase 1, mitochondrial Enzyme WOMBAT-PK
Glutamate receptor ionotropic, kainate 4 Ion channel Ki 7.74 PDSP
Glutamate receptor 3 Ion channel Ki 6.60 PDSP
Metabotropic glutamate receptor 7 GPCR EC50 5.93 CHEMBL
Excitatory amino acid transporter 3 Transporter Ki 7.29 CHEMBL
Adenosine receptor A3 GPCR IC50 6.21 CHEMBL
Metabotropic glutamate receptor 1 GPCR Ki 6.60 CHEMBL
Metabotropic glutamate receptor 2 GPCR EC50 6.54 CHEMBL
Metabotropic glutamate receptor 5 GPCR Ki 6.41 CHEMBL
Glutamate receptor ionotropic, kainate 1 Ion channel Ki 6.15 CHEMBL
Glutamate receptor ionotropic, kainate 5 Ion channel Ki 6.15 CHEMBL
Glutamate receptor ionotropic, kainate 3 Ion channel Ki 6.10 CHEMBL
Glutamate receptor 4 Ion channel Ki 6.06 CHEMBL
Glutamate receptor 2 Ion channel Ki 6.03 CHEMBL
Glutamate receptor ionotropic, kainate 2 Ion channel Ki 5.96 CHEMBL
Glutamate receptor 1 Ion channel Ki 5.87 CHEMBL
Metabotropic glutamate receptor 4 GPCR Ki 5.85 CHEMBL
Metabotropic glutamate receptor 6 GPCR EC50 5.31 CHEMBL
Excitatory amino acid transporter 1 Transporter Ki 4.46 CHEMBL
Glutathione reductase, mitochondrial Enzyme Ki 4.37 CHEMBL
Excitatory amino acid transporter 2 Transporter Ki 4.21 CHEMBL
Glutamate receptor 1 Ion channel EC50 4.46 CHEMBL
Glutamate receptor 2 Ion channel Ki 6.55 CHEMBL
Glutamate receptor 3 Ion channel EC50 4 CHEMBL
Glutamate receptor 4 Ion channel EC50 4.77 CHEMBL
Glutamate receptor ionotropic, kainate 1 Ion channel Ki 6.85 CHEMBL
Metabotropic glutamate receptor 1 Unclassified EC50 5 CHEMBL
Metabotropic glutamate receptor 2 Unclassified EC50 5.40 CHEMBL
Metabotropic glutamate receptor 3 Unclassified EC50 5.52 CHEMBL
Metabotropic glutamate receptor 4 GPCR EC50 4.92 CHEMBL
Metabotropic glutamate receptor 5 Unclassified EC50 5.36 CHEMBL
Metabotropic glutamate receptor 6 GPCR EC50 4.80 CHEMBL
Glutamate receptor ionotropic, NMDA 1 Ion channel EC50 5.54 CHEMBL
Glutamate receptor ionotropic, kainate 2 Ion channel Ki 5.48 CHEMBL
Glutamate receptor ionotropic, kainate 3 Ion channel Ki 6.31 CHEMBL
Metabotropic glutamate receptor 8 Unclassified EC50 7.66 CHEMBL
Metabotropic glutamate receptor 8 Unclassified Ki 5.47 CHEMBL
Glutamate racemase Unclassified Ki 4.55 CHEMBL
Glutamate racemase Unclassified Ki 5.24 CHEMBL

External reference:

IDSource
D00007 KEGG_DRUG
138-15-8 SECONDARY_CAS_RN
4018681 VANDF
C0220839 UMLSCUI
CHEBI:29987 CHEBI
GLU PDB_CHEM_ID
CHEMBL76232 ChEMBL_ID
CHEMBL575060 ChEMBL_ID
CHEMBL1255943 ChEMBL_ID
DB00142 DRUGBANK_ID
D018698 MESH_DESCRIPTOR_UI
1369 IUPHAR_LIGAND_ID
66 INN_ID
3KX376GY7L UNII
611 PUBCHEM_CID
25916 RXNORM
4788 MMSL
4823 MMSL
7086 MMSL
NOCODE MMSL
d00487 MMSL
001113 NDDF
008075 NDDF
010581 NDDF
38909000 SNOMEDCT_US
42271003 SNOMEDCT_US
85214009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
TrophAmine HUMAN PRESCRIPTION DRUG LABEL 20 0264-1933 SOLUTION 0.50 g INTRAVENOUS NDA 23 sections
Plenamine HUMAN PRESCRIPTION DRUG LABEL 17 0264-3200 SOLUTION 749 mg INTRAVENOUS ANDA 20 sections
Plenamine HUMAN PRESCRIPTION DRUG LABEL 17 0264-3205 SOLUTION 749 mg INTRAVENOUS ANDA 20 sections
Plenamine HUMAN PRESCRIPTION DRUG LABEL 17 0264-4500 SOLUTION 749 mg INTRAVENOUS ANDA 20 sections
TrophAmine HUMAN PRESCRIPTION DRUG LABEL 20 0264-9341 SOLUTION 0.50 g INTRAVENOUS NDA 23 sections
TrophAmine HUMAN PRESCRIPTION DRUG LABEL 20 0264-9361 SOLUTION 0.30 g INTRAVENOUS NDA 23 sections
ProSol HUMAN PRESCRIPTION DRUG LABEL 17 0338-0499 INJECTION, SOLUTION 1.02 g INTRAVENOUS NDA 21 sections
Clinisol HUMAN PRESCRIPTION DRUG LABEL 17 0338-0502 INJECTION, SOLUTION 749 mg INTRAVENOUS ANDA 18 sections
Aminosyn-PF HUMAN PRESCRIPTION DRUG LABEL 18 0409-4178 INJECTION, SOLUTION 576 mg INTRAVENOUS NDA 14 sections
Aminosyn II HUMAN PRESCRIPTION DRUG LABEL 17 0409-7171 INJECTION, SOLUTION 1107 mg INTRAVENOUS NDA 19 sections
Aminosyn II HUMAN PRESCRIPTION DRUG LABEL 17 0409-7172 INJECTION, SOLUTION 738 mg INTRAVENOUS NDA 19 sections
Aminosyn-PF HUMAN PRESCRIPTION DRUG LABEL 18 0990-4179 INJECTION, SOLUTION 820 mg INTRAVENOUS NDA 14 sections
Aminosyn II HUMAN PRESCRIPTION DRUG LABEL 17 0990-7171 INJECTION, SOLUTION 1107 mg INTRAVENOUS NDA 19 sections
Aminosyn II HUMAN PRESCRIPTION DRUG LABEL 17 0990-7172 INJECTION, SOLUTION 738 mg INTRAVENOUS NDA 19 sections
Kabiven HUMAN PRESCRIPTION DRUG LABEL 24 63323-712 INJECTION, EMULSION 164 mg INTRAVENOUS NDA 25 sections
Perikabiven HUMAN PRESCRIPTION DRUG LABEL 24 63323-714 INJECTION, EMULSION 116 mg INTRAVENOUS NDA 25 sections
Women Secret Care HUMAN OTC DRUG LABEL 2 72530-102 GEL 1.74 g TOPICAL unapproved drug other 8 sections