Stem definition | Drug id | CAS RN |
---|---|---|
Vitamin D analogues/derivatives | 130 | 41294-56-8 |
Dose | Unit | Route |
---|---|---|
1 | mcg | O |
1 | mcg | P |
10 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 8 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.00 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 71 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
CL (Clearance) | 0.82 mL/min/kg | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 48.60 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Jan. 1, 1978 | YEAR INTRODUCED |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Muscle spasticity | 458.93 | 14.88 | 184 | 16169 | 19776 | 56255938 |
Respiratory disorder | 397.81 | 14.88 | 195 | 16158 | 33762 | 56241952 |
Ear pain | 390.83 | 14.88 | 187 | 16166 | 30703 | 56245011 |
Body temperature increased | 366.65 | 14.88 | 185 | 16168 | 34057 | 56241657 |
Night sweats | 362.13 | 14.88 | 195 | 16158 | 41018 | 56234696 |
Hypocalcaemia | 177.06 | 14.88 | 108 | 16245 | 28652 | 56247062 |
Urticaria | 169.12 | 14.88 | 209 | 16144 | 144467 | 56131247 |
Lower respiratory tract infection | 166.03 | 14.88 | 185 | 16168 | 114609 | 56161105 |
Insomnia | 141.40 | 14.88 | 222 | 16131 | 191638 | 56084076 |
Back pain | 126.81 | 14.88 | 238 | 16115 | 236932 | 56038782 |
Abdominal pain upper | 117.26 | 14.88 | 196 | 16157 | 178117 | 56097597 |
Sinusitis | 101.46 | 14.88 | 195 | 16158 | 197386 | 56078328 |
Hypercalcaemia | 99.50 | 14.88 | 72 | 16281 | 25339 | 56250375 |
Pruritus | 95.77 | 14.88 | 253 | 16100 | 316370 | 55959344 |
Peripheral swelling | 92.77 | 14.88 | 208 | 16145 | 234518 | 56041196 |
Upper respiratory tract inflammation | 90.18 | 14.88 | 32 | 16321 | 2445 | 56273269 |
Hepatic function abnormal | 83.99 | 14.88 | 74 | 16279 | 34484 | 56241230 |
Shunt stenosis | 83.07 | 14.88 | 21 | 16332 | 492 | 56275222 |
Osteonecrosis of jaw | 80.20 | 14.88 | 71 | 16282 | 33287 | 56242427 |
Spinal compression fracture | 79.96 | 14.88 | 49 | 16304 | 13085 | 56262629 |
Renal impairment | 79.10 | 14.88 | 107 | 16246 | 80606 | 56195108 |
Drug ineffective | 78.99 | 14.88 | 91 | 16262 | 918898 | 55356816 |
Asthenia | 68.59 | 14.88 | 237 | 16116 | 342736 | 55932978 |
Vomiting | 66.37 | 14.88 | 303 | 16050 | 497925 | 55777789 |
Incorrect route of product administration | 58.58 | 14.88 | 49 | 16304 | 21280 | 56254434 |
Diarrhoea | 57.91 | 14.88 | 349 | 16004 | 638158 | 55637556 |
Fatigue | 54.66 | 14.88 | 91 | 16262 | 788461 | 55487253 |
Rheumatoid arthritis | 53.76 | 14.88 | 22 | 16331 | 382582 | 55893132 |
Rash | 52.87 | 14.88 | 282 | 16071 | 492765 | 55782949 |
Joint swelling | 51.67 | 14.88 | 193 | 16160 | 289607 | 55986107 |
Drug intolerance | 46.67 | 14.88 | 10 | 16343 | 264808 | 56010906 |
Product dose omission issue | 44.78 | 14.88 | 4 | 16349 | 204749 | 56070965 |
Blood parathyroid hormone increased | 41.02 | 14.88 | 19 | 16334 | 2886 | 56272828 |
Drug hypersensitivity | 39.98 | 14.88 | 15 | 16338 | 275190 | 56000524 |
Shunt occlusion | 38.96 | 14.88 | 12 | 16341 | 588 | 56275126 |
Atypical femur fracture | 36.38 | 14.88 | 21 | 16332 | 5026 | 56270688 |
Interstitial lung disease | 33.82 | 14.88 | 60 | 16293 | 57003 | 56218711 |
Nausea | 33.74 | 14.88 | 112 | 16241 | 764066 | 55511648 |
Hyperuricaemia | 33.64 | 14.88 | 20 | 16333 | 5053 | 56270661 |
Tetany | 33.39 | 14.88 | 14 | 16339 | 1678 | 56274036 |
Alopecia | 32.24 | 14.88 | 23 | 16330 | 293435 | 55982279 |
Cerebral infarction | 31.98 | 14.88 | 36 | 16317 | 22469 | 56253245 |
Toxoplasmosis | 31.91 | 14.88 | 13 | 16340 | 1449 | 56274265 |
Abdominal discomfort | 31.43 | 14.88 | 21 | 16332 | 277253 | 55998461 |
Enteritis infectious | 31.11 | 14.88 | 14 | 16339 | 1990 | 56273724 |
Lymph node palpable | 31.08 | 14.88 | 7 | 16346 | 98 | 56275616 |
Cardiac failure | 29.29 | 14.88 | 70 | 16283 | 82023 | 56193691 |
Large intestine polyp | 28.46 | 14.88 | 21 | 16332 | 7606 | 56268108 |
Headache | 27.98 | 14.88 | 266 | 16087 | 558778 | 55716936 |
Iron deficiency anaemia | 27.77 | 14.88 | 30 | 16323 | 17889 | 56257825 |
Anxiety | 25.67 | 14.88 | 12 | 16341 | 193160 | 56082554 |
Milk-alkali syndrome | 25.34 | 14.88 | 9 | 16344 | 689 | 56275025 |
Gastroenteritis | 24.85 | 14.88 | 33 | 16320 | 24379 | 56251335 |
Arthropathy | 24.30 | 14.88 | 14 | 16339 | 200261 | 56075453 |
Toxicity to various agents | 24.13 | 14.88 | 18 | 16335 | 224546 | 56051168 |
Death | 23.89 | 14.88 | 39 | 16314 | 341387 | 55934327 |
Beta 2 microglobulin urine increased | 23.66 | 14.88 | 5 | 16348 | 51 | 56275663 |
Treatment failure | 23.55 | 14.88 | 10 | 16343 | 170382 | 56105332 |
Osteomyelitis | 23.40 | 14.88 | 32 | 16321 | 24314 | 56251400 |
Nephrogenic anaemia | 22.45 | 14.88 | 11 | 16342 | 1893 | 56273821 |
Periodontitis | 22.37 | 14.88 | 13 | 16340 | 3150 | 56272564 |
Anaemia | 22.05 | 14.88 | 143 | 16210 | 267368 | 56008346 |
Haemodialysis complication | 21.80 | 14.88 | 6 | 16347 | 197 | 56275517 |
Peritonitis | 21.47 | 14.88 | 25 | 16328 | 16177 | 56259537 |
Calciphylaxis | 21.25 | 14.88 | 12 | 16341 | 2755 | 56272959 |
Oncocytoma | 21.10 | 14.88 | 4 | 16349 | 22 | 56275692 |
Glossodynia | 20.99 | 14.88 | 9 | 16344 | 152449 | 56123265 |
Enterocolitis viral | 20.80 | 14.88 | 6 | 16347 | 234 | 56275480 |
Platelet count decreased | 20.71 | 14.88 | 73 | 16280 | 106310 | 56169404 |
Peripheral arterial occlusive disease | 20.01 | 14.88 | 13 | 16340 | 3837 | 56271877 |
Premature rupture of membranes | 19.78 | 14.88 | 14 | 16339 | 4751 | 56270963 |
Immunosuppressant drug level increased | 19.45 | 14.88 | 12 | 16341 | 3241 | 56272473 |
Ileus | 19.37 | 14.88 | 22 | 16331 | 13860 | 56261854 |
Pneumonia aspiration | 19.09 | 14.88 | 34 | 16319 | 32377 | 56243337 |
Pemphigus | 19.05 | 14.88 | 11 | 16342 | 157201 | 56118513 |
Enterocolitis | 18.84 | 14.88 | 16 | 16337 | 7088 | 56268626 |
Infusion related reaction | 18.54 | 14.88 | 20 | 16333 | 208911 | 56066803 |
Hand deformity | 18.41 | 14.88 | 8 | 16345 | 134484 | 56141230 |
Musculoskeletal stiffness | 17.41 | 14.88 | 12 | 16341 | 155995 | 56119719 |
Neuropsychiatric lupus | 17.38 | 14.88 | 5 | 16348 | 193 | 56275521 |
Precocious puberty | 16.80 | 14.88 | 5 | 16348 | 218 | 56275496 |
Marasmus | 16.69 | 14.88 | 6 | 16347 | 476 | 56275238 |
Community acquired infection | 16.61 | 14.88 | 3 | 16350 | 12 | 56275702 |
Colon cancer | 16.58 | 14.88 | 17 | 16336 | 9544 | 56266170 |
Disseminated intravascular coagulation | 16.42 | 14.88 | 23 | 16330 | 17862 | 56257852 |
Blood albumin decreased | 16.36 | 14.88 | 20 | 16333 | 13608 | 56262106 |
Product monitoring error | 16.33 | 14.88 | 11 | 16342 | 3448 | 56272266 |
Neurosis | 16.23 | 14.88 | 5 | 16348 | 245 | 56275469 |
Hyperphosphataemia | 16.10 | 14.88 | 9 | 16344 | 2026 | 56273688 |
Pharyngitis | 15.79 | 14.88 | 23 | 16330 | 18515 | 56257199 |
Hyperhidrosis | 15.66 | 14.88 | 4 | 16349 | 94084 | 56181630 |
Hungry bone syndrome | 15.65 | 14.88 | 4 | 16349 | 98 | 56275616 |
Oesophageal mucosal tear | 15.60 | 14.88 | 3 | 16350 | 18 | 56275696 |
Autoimmune pancytopenia | 15.57 | 14.88 | 4 | 16349 | 100 | 56275614 |
Retinal haemorrhage | 15.47 | 14.88 | 12 | 16341 | 4679 | 56271035 |
Immobilisation syndrome | 15.37 | 14.88 | 5 | 16348 | 293 | 56275421 |
Feeling abnormal | 15.28 | 14.88 | 10 | 16343 | 133592 | 56142122 |
Calculus urinary | 15.14 | 14.88 | 7 | 16346 | 1058 | 56274656 |
Wound | 15.06 | 14.88 | 11 | 16342 | 138793 | 56136921 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hypocalcaemia | 139.30 | 17.57 | 79 | 7647 | 21899 | 31667719 |
Shunt stenosis | 134.26 | 17.57 | 32 | 7694 | 701 | 31688917 |
Shunt occlusion | 110.26 | 17.57 | 28 | 7698 | 803 | 31688815 |
Oesophageal perforation | 91.30 | 17.57 | 25 | 7701 | 965 | 31688653 |
Soft tissue mass | 86.00 | 17.57 | 23 | 7703 | 811 | 31688807 |
Multimorbidity | 83.78 | 17.57 | 22 | 7704 | 722 | 31688896 |
Immunosuppressant drug level increased | 78.64 | 17.57 | 34 | 7692 | 5251 | 31684367 |
Superinfection | 63.84 | 17.57 | 23 | 7703 | 2195 | 31687423 |
Transplant failure | 63.07 | 17.57 | 25 | 7701 | 3101 | 31686517 |
Myocardial ischaemia | 51.10 | 17.57 | 38 | 7688 | 16629 | 31672989 |
Inflammatory marker increased | 49.75 | 17.57 | 23 | 7703 | 4155 | 31685463 |
Labelled drug-drug interaction medication error | 49.53 | 17.57 | 34 | 7692 | 13129 | 31676489 |
Renal impairment | 48.10 | 17.57 | 80 | 7646 | 86269 | 31603349 |
Osteonecrosis of jaw | 48.08 | 17.57 | 37 | 7689 | 17034 | 31672584 |
Oesophageal carcinoma | 45.84 | 17.57 | 27 | 7699 | 8006 | 31681612 |
Hepatic function abnormal | 45.30 | 17.57 | 53 | 7673 | 41169 | 31648449 |
Lung consolidation | 43.85 | 17.57 | 23 | 7703 | 5450 | 31684168 |
Upper respiratory tract inflammation | 43.02 | 17.57 | 16 | 7710 | 1670 | 31687948 |
Procalcitonin abnormal | 41.59 | 17.57 | 11 | 7715 | 371 | 31689247 |
Cardiomegaly | 37.88 | 17.57 | 30 | 7696 | 14395 | 31675223 |
Drug level increased | 34.78 | 17.57 | 33 | 7693 | 20153 | 31669465 |
Aplasia pure red cell | 34.63 | 17.57 | 20 | 7706 | 5717 | 31683901 |
Rales | 34.12 | 17.57 | 23 | 7703 | 8616 | 31681002 |
Encephalomalacia | 32.92 | 17.57 | 11 | 7715 | 838 | 31688780 |
Anti-erythropoietin antibody negative | 32.43 | 17.57 | 8 | 7718 | 203 | 31689415 |
Neuromyopathy | 31.36 | 17.57 | 11 | 7715 | 970 | 31688648 |
Drug ineffective | 30.52 | 17.57 | 31 | 7695 | 395542 | 31294076 |
Hypercalcaemia | 30.24 | 17.57 | 26 | 7700 | 13974 | 31675644 |
Calciphylaxis | 30.22 | 17.57 | 11 | 7715 | 1080 | 31688538 |
C-reactive protein increased | 26.94 | 17.57 | 45 | 7681 | 48605 | 31641013 |
PO2 decreased | 26.61 | 17.57 | 11 | 7715 | 1518 | 31688100 |
Device related sepsis | 26.25 | 17.57 | 13 | 7713 | 2731 | 31686887 |
Retinopathy hypertensive | 25.56 | 17.57 | 7 | 7719 | 270 | 31689348 |
PCO2 decreased | 25.50 | 17.57 | 11 | 7715 | 1687 | 31687931 |
Cerebral infarction | 24.61 | 17.57 | 31 | 7695 | 25946 | 31663672 |
Pleural effusion | 23.99 | 17.57 | 55 | 7671 | 74865 | 31614753 |
Fatigue | 23.91 | 17.57 | 28 | 7698 | 335178 | 31354440 |
Renal tubular acidosis | 22.98 | 17.57 | 11 | 7715 | 2146 | 31687472 |
Interstitial lung disease | 22.98 | 17.57 | 48 | 7678 | 61355 | 31628263 |
Drug interaction | 22.93 | 17.57 | 106 | 7620 | 208437 | 31481181 |
Lymphocyte count increased | 22.65 | 17.57 | 12 | 7714 | 2901 | 31686717 |
Hungry bone syndrome | 21.95 | 17.57 | 5 | 7721 | 89 | 31689529 |
Nephrotic syndrome | 21.53 | 17.57 | 16 | 7710 | 6987 | 31682631 |
Dysphagia | 21.48 | 17.57 | 45 | 7681 | 57631 | 31631987 |
Ascites | 21.47 | 17.57 | 37 | 7689 | 40976 | 31648642 |
Extraskeletal ossification | 20.85 | 17.57 | 4 | 7722 | 29 | 31689589 |
Monocyte count increased | 20.75 | 17.57 | 13 | 7713 | 4302 | 31685316 |
Hepatosplenomegaly neonatal | 19.70 | 17.57 | 4 | 7722 | 40 | 31689578 |
Lower respiratory tract infection | 19.63 | 17.57 | 29 | 7697 | 28208 | 31661410 |
Bradycardia foetal | 19.46 | 17.57 | 6 | 7720 | 353 | 31689265 |
Myeloperoxidase deficiency | 19.35 | 17.57 | 4 | 7722 | 44 | 31689574 |
Acute kidney injury | 19.16 | 17.57 | 125 | 7601 | 279589 | 31410029 |
Immune thrombocytopenia | 18.79 | 17.57 | 16 | 7710 | 8482 | 31681136 |
Disseminated intravascular coagulation | 18.65 | 17.57 | 24 | 7702 | 20513 | 31669105 |
Peripheral arterial occlusive disease | 18.24 | 17.57 | 13 | 7713 | 5320 | 31684298 |
Hyperkalaemia | 18.17 | 17.57 | 45 | 7681 | 64306 | 31625312 |
Haemoptysis | 18.11 | 17.57 | 30 | 7696 | 32159 | 31657459 |
Pneumonia | 17.85 | 17.57 | 141 | 7585 | 335171 | 31354447 |
Nail discolouration | 17.70 | 17.57 | 7 | 7719 | 862 | 31688756 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hypocalcaemia | 270.99 | 13.03 | 170 | 21687 | 44689 | 70861898 |
Shunt stenosis | 205.89 | 13.03 | 53 | 21804 | 1259 | 70905328 |
Muscle spasticity | 189.31 | 13.03 | 101 | 21756 | 19588 | 70886999 |
Ear pain | 162.60 | 13.03 | 103 | 21754 | 27496 | 70879091 |
Respiratory disorder | 147.70 | 13.03 | 111 | 21746 | 39012 | 70867575 |
Shunt occlusion | 141.23 | 13.03 | 40 | 21817 | 1375 | 70905212 |
Body temperature increased | 137.16 | 13.03 | 107 | 21750 | 39727 | 70866860 |
Night sweats | 136.86 | 13.03 | 111 | 21746 | 43573 | 70863014 |
Upper respiratory tract inflammation | 126.08 | 13.03 | 47 | 21810 | 3895 | 70902692 |
Hypercalcaemia | 121.94 | 13.03 | 94 | 21763 | 34291 | 70872296 |
Osteonecrosis of jaw | 121.76 | 13.03 | 101 | 21756 | 40901 | 70865686 |
Hepatic function abnormal | 119.45 | 13.03 | 125 | 21732 | 67871 | 70838716 |
Renal impairment | 107.20 | 13.03 | 173 | 21684 | 143764 | 70762823 |
Spinal compression fracture | 99.04 | 13.03 | 61 | 21796 | 15492 | 70891095 |
Drug ineffective | 88.46 | 13.03 | 96 | 21761 | 939656 | 69966931 |
Oesophageal perforation | 82.06 | 13.03 | 26 | 21831 | 1318 | 70905269 |
Lower respiratory tract infection | 75.87 | 13.03 | 129 | 21728 | 111784 | 70794803 |
Soft tissue mass | 70.39 | 13.03 | 22 | 21835 | 1066 | 70905521 |
Fatigue | 67.16 | 13.03 | 94 | 21763 | 824225 | 70082362 |
Multimorbidity | 64.54 | 13.03 | 21 | 21836 | 1160 | 70905427 |
Immunosuppressant drug level increased | 63.41 | 13.03 | 36 | 21821 | 7871 | 70898716 |
Blood parathyroid hormone increased | 59.79 | 13.03 | 26 | 21831 | 3211 | 70903376 |
Interstitial lung disease | 53.68 | 13.03 | 107 | 21750 | 104578 | 70802009 |
Cerebral infarction | 53.27 | 13.03 | 66 | 21791 | 42943 | 70863644 |
Transplant failure | 50.86 | 13.03 | 25 | 21832 | 4082 | 70902505 |
Aplasia pure red cell | 49.70 | 13.03 | 30 | 21827 | 7344 | 70899243 |
Urticaria | 47.85 | 13.03 | 134 | 21723 | 162915 | 70743672 |
Superinfection | 44.46 | 13.03 | 23 | 21834 | 4183 | 70902404 |
Insomnia | 43.72 | 13.03 | 157 | 21700 | 217649 | 70688938 |
Incorrect route of product administration | 43.47 | 13.03 | 47 | 21810 | 26445 | 70880142 |
Hyperuricaemia | 41.10 | 13.03 | 31 | 21826 | 10935 | 70895652 |
Product dose omission issue | 40.02 | 13.03 | 9 | 21848 | 217459 | 70689128 |
Platelet count decreased | 39.70 | 13.03 | 133 | 21724 | 178089 | 70728498 |
Peripheral arterial occlusive disease | 39.23 | 13.03 | 26 | 21831 | 7483 | 70899104 |
Procalcitonin abnormal | 38.98 | 13.03 | 11 | 21846 | 373 | 70906214 |
Drug intolerance | 38.34 | 13.03 | 11 | 21846 | 225676 | 70680911 |
Labelled drug-drug interaction medication error | 36.46 | 13.03 | 41 | 21816 | 24086 | 70882501 |
Hungry bone syndrome | 36.19 | 13.03 | 9 | 21848 | 185 | 70906402 |
Back pain | 35.92 | 13.03 | 172 | 21685 | 270980 | 70635607 |
Tetany | 34.89 | 13.03 | 16 | 21841 | 2238 | 70904349 |
Disseminated intravascular coagulation | 34.49 | 13.03 | 47 | 21810 | 33551 | 70873036 |
Drug hypersensitivity | 34.44 | 13.03 | 19 | 21838 | 262440 | 70644147 |
Inflammatory marker increased | 34.28 | 13.03 | 26 | 21831 | 9248 | 70897339 |
Oesophageal carcinoma | 34.05 | 13.03 | 26 | 21831 | 9340 | 70897247 |
Anaemia | 33.04 | 13.03 | 225 | 21632 | 403198 | 70503389 |
Myocardial ischaemia | 33 | 13.03 | 39 | 21818 | 24161 | 70882426 |
Diarrhoea | 32.89 | 13.03 | 377 | 21480 | 782964 | 70123623 |
Completed suicide | 31.96 | 13.03 | 15 | 21842 | 227120 | 70679467 |
Large intestine polyp | 31.43 | 13.03 | 27 | 21830 | 11449 | 70895138 |
Calciphylaxis | 31.09 | 13.03 | 17 | 21840 | 3456 | 70903131 |
Gastroenteritis | 31.04 | 13.03 | 43 | 21814 | 31170 | 70875417 |
Enteritis infectious | 29.76 | 13.03 | 16 | 21841 | 3146 | 70903441 |
Abdominal pain upper | 29.48 | 13.03 | 128 | 21729 | 193474 | 70713113 |
Nausea | 29.45 | 13.03 | 149 | 21708 | 851939 | 70054648 |
Rheumatoid arthritis | 29.34 | 13.03 | 28 | 21829 | 291777 | 70614810 |
Anti-erythropoietin antibody negative | 27.97 | 13.03 | 8 | 21849 | 285 | 70906302 |
Lung consolidation | 27.90 | 13.03 | 22 | 21835 | 8284 | 70898303 |
Lymph node palpable | 27.87 | 13.03 | 7 | 21850 | 150 | 70906437 |
Pruritus | 27.84 | 13.03 | 192 | 21665 | 345368 | 70561219 |
Pneumonia aspiration | 27.62 | 13.03 | 60 | 21797 | 62229 | 70844358 |
Periodontitis | 27.61 | 13.03 | 17 | 21840 | 4311 | 70902276 |
Cardiac failure | 27.53 | 13.03 | 102 | 21755 | 143439 | 70763148 |
Hyperhidrosis | 27.32 | 13.03 | 4 | 21853 | 131582 | 70775005 |
Encephalomalacia | 26.82 | 13.03 | 11 | 21846 | 1175 | 70905412 |
Atypical femur fracture | 25.86 | 13.03 | 17 | 21840 | 4826 | 70901761 |
Hyperphosphataemia | 25.27 | 13.03 | 16 | 21841 | 4260 | 70902327 |
Neuromyopathy | 24.58 | 13.03 | 11 | 21846 | 1454 | 70905133 |
Toxoplasmosis | 23.98 | 13.03 | 13 | 21844 | 2597 | 70903990 |
Anxiety | 23.50 | 13.03 | 20 | 21837 | 220310 | 70686277 |
Beta 2 microglobulin urine increased | 23.49 | 13.03 | 6 | 21851 | 138 | 70906449 |
Peritonitis | 23.01 | 13.03 | 34 | 21823 | 26125 | 70880462 |
Sinusitis | 22.86 | 13.03 | 108 | 21749 | 169087 | 70737500 |
Enterocolitis viral | 22.09 | 13.03 | 7 | 21850 | 355 | 70906232 |
Iron deficiency anaemia | 21.77 | 13.03 | 31 | 21826 | 23041 | 70883546 |
Hypophosphataemia | 21.75 | 13.03 | 26 | 21831 | 16300 | 70890287 |
Premature rupture of membranes | 21.59 | 13.03 | 14 | 21843 | 3884 | 70902703 |
Liver disorder | 21.48 | 13.03 | 54 | 21803 | 61514 | 70845073 |
Nephrotic syndrome | 21.28 | 13.03 | 21 | 21836 | 10619 | 70895968 |
Immobilisation syndrome | 20.67 | 13.03 | 7 | 21850 | 438 | 70906149 |
Osteomyelitis | 20.58 | 13.03 | 35 | 21822 | 30283 | 70876304 |
Rash | 20.58 | 13.03 | 244 | 21613 | 510318 | 70396269 |
Intentional overdose | 20.41 | 13.03 | 3 | 21854 | 98432 | 70808155 |
Cardiomegaly | 20.31 | 13.03 | 31 | 21826 | 24514 | 70882073 |
Pharyngitis | 20.18 | 13.03 | 28 | 21829 | 20323 | 70886264 |
Retinopathy hypertensive | 20.12 | 13.03 | 7 | 21850 | 475 | 70906112 |
Milk-alkali syndrome | 20.01 | 13.03 | 9 | 21848 | 1204 | 70905383 |
Vomiting | 19.91 | 13.03 | 274 | 21583 | 592837 | 70313750 |
Oncocytoma | 19.79 | 13.03 | 4 | 21853 | 30 | 70906557 |
Treatment failure | 19.54 | 13.03 | 10 | 21847 | 144132 | 70762455 |
Death | 19.43 | 13.03 | 86 | 21771 | 509975 | 70396612 |
Enterocolitis | 19.39 | 13.03 | 22 | 21835 | 13044 | 70893543 |
Decreased appetite | 19.26 | 13.03 | 160 | 21697 | 304620 | 70601967 |
Haemodialysis complication | 19.03 | 13.03 | 6 | 21851 | 299 | 70906288 |
Hyperparathyroidism secondary | 18.79 | 13.03 | 11 | 21846 | 2547 | 70904040 |
Immune thrombocytopenia | 18.54 | 13.03 | 24 | 21833 | 16300 | 70890287 |
Renal tubular acidosis | 18.36 | 13.03 | 12 | 21845 | 3374 | 70903213 |
PO2 decreased | 17.81 | 13.03 | 11 | 21846 | 2803 | 70903784 |
Premature delivery | 17.76 | 13.03 | 27 | 21830 | 21277 | 70885310 |
Injection site pain | 17.75 | 13.03 | 7 | 21850 | 117612 | 70788975 |
Chronic gastritis | 17.65 | 13.03 | 12 | 21845 | 3601 | 70902986 |
Nephrogenic anaemia | 17.63 | 13.03 | 12 | 21845 | 3606 | 70902981 |
Neuropsychiatric lupus | 17.45 | 13.03 | 5 | 21852 | 179 | 70906408 |
PCO2 decreased | 17.15 | 13.03 | 11 | 21846 | 2993 | 70903594 |
Abdominal discomfort | 16.86 | 13.03 | 25 | 21832 | 214633 | 70691954 |
Calcium metabolism disorder | 16.86 | 13.03 | 4 | 21853 | 67 | 70906520 |
Hypotension | 16.75 | 13.03 | 66 | 21791 | 404315 | 70502272 |
Pyrexia | 16.69 | 13.03 | 271 | 21586 | 606681 | 70299906 |
Pneumonia bacterial | 16.65 | 13.03 | 23 | 21834 | 16618 | 70889969 |
Hyperkalaemia | 16.61 | 13.03 | 71 | 21786 | 106520 | 70800067 |
Infusion related reaction | 16.52 | 13.03 | 22 | 21835 | 197512 | 70709075 |
Skin erosion | 16.50 | 13.03 | 12 | 21845 | 4004 | 70902583 |
Colon cancer | 16.20 | 13.03 | 21 | 21836 | 14285 | 70892302 |
Rales | 16.13 | 13.03 | 23 | 21834 | 17112 | 70889475 |
Pain in extremity | 15.96 | 13.03 | 50 | 21807 | 328032 | 70578555 |
Haemoptysis | 15.77 | 13.03 | 43 | 21814 | 51409 | 70855178 |
Oesophageal mucosal tear | 15.72 | 13.03 | 3 | 21854 | 16 | 70906571 |
Shunt malfunction | 15.71 | 13.03 | 5 | 21852 | 257 | 70906330 |
Marasmus | 15.67 | 13.03 | 7 | 21850 | 921 | 70905666 |
Concomitant disease aggravated | 15.66 | 13.03 | 19 | 21838 | 12095 | 70894492 |
Ascites | 15.54 | 13.03 | 51 | 21806 | 67496 | 70839091 |
Haemorrhage subcutaneous | 15.26 | 13.03 | 12 | 21845 | 4497 | 70902090 |
C-reactive protein increased | 15.25 | 13.03 | 71 | 21786 | 110446 | 70796141 |
Feeling abnormal | 15.07 | 13.03 | 13 | 21844 | 142306 | 70764281 |
Drug level increased | 14.89 | 13.03 | 34 | 21823 | 36435 | 70870152 |
Depression | 14.84 | 13.03 | 24 | 21833 | 198950 | 70707637 |
Weight increased | 14.77 | 13.03 | 33 | 21824 | 242298 | 70664289 |
Cholangitis | 14.74 | 13.03 | 18 | 21839 | 11531 | 70895056 |
Device related sepsis | 14.73 | 13.03 | 13 | 21844 | 5715 | 70900872 |
Chronic obstructive pulmonary disease | 14.71 | 13.03 | 3 | 21854 | 77638 | 70828949 |
Precocious puberty | 14.67 | 13.03 | 5 | 21852 | 319 | 70906268 |
Loss of personal independence in daily activities | 14.66 | 13.03 | 4 | 21853 | 84906 | 70821681 |
Community acquired infection | 14.46 | 13.03 | 3 | 21854 | 26 | 70906561 |
Protein urine present | 14.19 | 13.03 | 16 | 21841 | 9424 | 70897163 |
Sepsis | 14.19 | 13.03 | 126 | 21731 | 244419 | 70662168 |
Pneumonia | 14.14 | 13.03 | 260 | 21597 | 595972 | 70310615 |
Osteoporosis | 14.13 | 13.03 | 40 | 21817 | 48867 | 70857720 |
Shunt aneurysm | 14.07 | 13.03 | 3 | 21854 | 30 | 70906557 |
Hypoglycaemia | 14.05 | 13.03 | 62 | 21795 | 94302 | 70812285 |
Ileus | 13.91 | 13.03 | 26 | 21831 | 24211 | 70882376 |
Musculoskeletal stiffness | 13.90 | 13.03 | 15 | 21842 | 147745 | 70758842 |
Alopecia | 13.83 | 13.03 | 25 | 21832 | 198465 | 70708122 |
Myeloperoxidase deficiency | 13.81 | 13.03 | 3 | 21854 | 33 | 70906554 |
Neurosis | 13.61 | 13.03 | 5 | 21852 | 397 | 70906190 |
Lymphocyte count increased | 13.58 | 13.03 | 12 | 21845 | 5284 | 70901303 |
Pemphigoid | 13.46 | 13.03 | 19 | 21838 | 14003 | 70892584 |
Dermatophytosis of nail | 13.30 | 13.03 | 4 | 21853 | 170 | 70906417 |
Arthropathy | 13.28 | 13.03 | 16 | 21841 | 150041 | 70756546 |
Suicide attempt | 13.26 | 13.03 | 4 | 21853 | 79506 | 70827081 |
Stag horn calculus | 13.26 | 13.03 | 4 | 21853 | 172 | 70906415 |
Pyelonephritis acute | 13.15 | 13.03 | 12 | 21845 | 5505 | 70901082 |
Calculus urinary | 13.04 | 13.03 | 8 | 21849 | 2016 | 70904571 |
None
Source | Code | Description |
---|---|---|
ATC | A11CC03 | ALIMENTARY TRACT AND METABOLISM VITAMINS VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO Vitamin D and analogues |
ATC | M05BB06 | MUSCULO-SKELETAL SYSTEM DRUGS FOR TREATMENT OF BONE DISEASES DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION Bisphosphonates, combinations |
MeSH PA | D050071 | Bone Density Conservation Agents |
CHEBI has role | CHEBI:50646 | antiosteoporotic |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Renal osteodystrophy | indication | 16726004 | DOID:13068 |
Hypoparathyroidism | indication | 36976004 | DOID:11199 |
Hyperparathyroidism | indication | 66999008 | DOID:13543 |
Neonatal hypocalcemia | indication | 268846006 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 13.7 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Vitamin D3 receptor | Nuclear hormone receptor | AGONIST | WOMBAT-PK | KEGG DRUG | |||||
Sodium-dependent noradrenaline transporter | Transporter | Ki | 6 | DRUG MATRIX |
ID | Source |
---|---|
D01518 | KEGG_DRUG |
12062 | RXNORM |
C0044410 | UMLSCUI |
CHEBI:31186 | CHEBI |
M9B | PDB_CHEM_ID |
CHEMBL1601669 | ChEMBL_ID |
DB01436 | DRUGBANK_ID |
C008088 | MESH_SUPPLEMENTAL_RECORD_UI |
5282181 | PUBCHEM_CID |
4489 | INN_ID |
URQ2517572 | UNII |
003501 | NDDF |
11984007 | SNOMEDCT_US |
329325000 | SNOMEDCT_US |
None