alfacalcidol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
Vitamin D analogues/derivatives	130	41294-56-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: alfacalcidol 1alpha-Hydroxycholecalciferol alfarol alphacalcidol einsalpha alpha-calcidol 1-hydroxycholecalciferol	Molecular weight: 400.65 Formula: C27H44O2 CLOGP: 8.24 LIPINSKI: 1 HAC: 2 HDO: 2 TPSA: 40.46 ALOGS: -5.39 ROTB: 6

Molecule

Description

Molfile Inchi Smiles

Synonyms:

alfacalcidol
1alpha-Hydroxycholecalciferol
alfarol
alphacalcidol
einsalpha
alpha-calcidol
1-hydroxycholecalciferol

Molecular weight: 400.65
Formula: C27H44O2
CLOGP: 8.24
LIPINSKI: 1
HAC: 2
HDO: 2
TPSA: 40.46
ALOGS: -5.39
ROTB: 6

Drug dosage:

Dose	Unit	Route
1	mcg	O
1	mcg	P
10	mg	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	8 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.00 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	71 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
CL (Clearance)	0.82 mL/min/kg	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	48.60 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Jan. 1, 1978	YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Muscle spasticity	458.93	14.88	184	16169	19776	56255938
Respiratory disorder	397.81	14.88	195	16158	33762	56241952
Ear pain	390.83	14.88	187	16166	30703	56245011
Body temperature increased	366.65	14.88	185	16168	34057	56241657
Night sweats	362.13	14.88	195	16158	41018	56234696
Hypocalcaemia	177.06	14.88	108	16245	28652	56247062
Urticaria	169.12	14.88	209	16144	144467	56131247
Lower respiratory tract infection	166.03	14.88	185	16168	114609	56161105
Insomnia	141.40	14.88	222	16131	191638	56084076
Back pain	126.81	14.88	238	16115	236932	56038782
Abdominal pain upper	117.26	14.88	196	16157	178117	56097597
Sinusitis	101.46	14.88	195	16158	197386	56078328
Hypercalcaemia	99.50	14.88	72	16281	25339	56250375
Pruritus	95.77	14.88	253	16100	316370	55959344
Peripheral swelling	92.77	14.88	208	16145	234518	56041196
Upper respiratory tract inflammation	90.18	14.88	32	16321	2445	56273269
Hepatic function abnormal	83.99	14.88	74	16279	34484	56241230
Shunt stenosis	83.07	14.88	21	16332	492	56275222
Osteonecrosis of jaw	80.20	14.88	71	16282	33287	56242427
Spinal compression fracture	79.96	14.88	49	16304	13085	56262629
Renal impairment	79.10	14.88	107	16246	80606	56195108
Drug ineffective	78.99	14.88	91	16262	918898	55356816
Asthenia	68.59	14.88	237	16116	342736	55932978
Vomiting	66.37	14.88	303	16050	497925	55777789
Incorrect route of product administration	58.58	14.88	49	16304	21280	56254434
Diarrhoea	57.91	14.88	349	16004	638158	55637556
Fatigue	54.66	14.88	91	16262	788461	55487253
Rheumatoid arthritis	53.76	14.88	22	16331	382582	55893132
Rash	52.87	14.88	282	16071	492765	55782949
Joint swelling	51.67	14.88	193	16160	289607	55986107
Drug intolerance	46.67	14.88	10	16343	264808	56010906
Product dose omission issue	44.78	14.88	4	16349	204749	56070965
Blood parathyroid hormone increased	41.02	14.88	19	16334	2886	56272828
Drug hypersensitivity	39.98	14.88	15	16338	275190	56000524
Shunt occlusion	38.96	14.88	12	16341	588	56275126
Atypical femur fracture	36.38	14.88	21	16332	5026	56270688
Interstitial lung disease	33.82	14.88	60	16293	57003	56218711
Nausea	33.74	14.88	112	16241	764066	55511648
Hyperuricaemia	33.64	14.88	20	16333	5053	56270661
Tetany	33.39	14.88	14	16339	1678	56274036
Alopecia	32.24	14.88	23	16330	293435	55982279
Cerebral infarction	31.98	14.88	36	16317	22469	56253245
Toxoplasmosis	31.91	14.88	13	16340	1449	56274265
Abdominal discomfort	31.43	14.88	21	16332	277253	55998461
Enteritis infectious	31.11	14.88	14	16339	1990	56273724
Lymph node palpable	31.08	14.88	7	16346	98	56275616
Cardiac failure	29.29	14.88	70	16283	82023	56193691
Large intestine polyp	28.46	14.88	21	16332	7606	56268108
Headache	27.98	14.88	266	16087	558778	55716936
Iron deficiency anaemia	27.77	14.88	30	16323	17889	56257825
Anxiety	25.67	14.88	12	16341	193160	56082554
Milk-alkali syndrome	25.34	14.88	9	16344	689	56275025
Gastroenteritis	24.85	14.88	33	16320	24379	56251335
Arthropathy	24.30	14.88	14	16339	200261	56075453
Toxicity to various agents	24.13	14.88	18	16335	224546	56051168
Death	23.89	14.88	39	16314	341387	55934327
Beta 2 microglobulin urine increased	23.66	14.88	5	16348	51	56275663
Treatment failure	23.55	14.88	10	16343	170382	56105332
Osteomyelitis	23.40	14.88	32	16321	24314	56251400
Nephrogenic anaemia	22.45	14.88	11	16342	1893	56273821
Periodontitis	22.37	14.88	13	16340	3150	56272564
Anaemia	22.05	14.88	143	16210	267368	56008346
Haemodialysis complication	21.80	14.88	6	16347	197	56275517
Peritonitis	21.47	14.88	25	16328	16177	56259537
Calciphylaxis	21.25	14.88	12	16341	2755	56272959
Oncocytoma	21.10	14.88	4	16349	22	56275692
Glossodynia	20.99	14.88	9	16344	152449	56123265
Enterocolitis viral	20.80	14.88	6	16347	234	56275480
Platelet count decreased	20.71	14.88	73	16280	106310	56169404
Peripheral arterial occlusive disease	20.01	14.88	13	16340	3837	56271877
Premature rupture of membranes	19.78	14.88	14	16339	4751	56270963
Immunosuppressant drug level increased	19.45	14.88	12	16341	3241	56272473
Ileus	19.37	14.88	22	16331	13860	56261854
Pneumonia aspiration	19.09	14.88	34	16319	32377	56243337
Pemphigus	19.05	14.88	11	16342	157201	56118513
Enterocolitis	18.84	14.88	16	16337	7088	56268626
Infusion related reaction	18.54	14.88	20	16333	208911	56066803
Hand deformity	18.41	14.88	8	16345	134484	56141230
Musculoskeletal stiffness	17.41	14.88	12	16341	155995	56119719
Neuropsychiatric lupus	17.38	14.88	5	16348	193	56275521
Precocious puberty	16.80	14.88	5	16348	218	56275496
Marasmus	16.69	14.88	6	16347	476	56275238
Community acquired infection	16.61	14.88	3	16350	12	56275702
Colon cancer	16.58	14.88	17	16336	9544	56266170
Disseminated intravascular coagulation	16.42	14.88	23	16330	17862	56257852
Blood albumin decreased	16.36	14.88	20	16333	13608	56262106
Product monitoring error	16.33	14.88	11	16342	3448	56272266
Neurosis	16.23	14.88	5	16348	245	56275469
Hyperphosphataemia	16.10	14.88	9	16344	2026	56273688
Pharyngitis	15.79	14.88	23	16330	18515	56257199
Hyperhidrosis	15.66	14.88	4	16349	94084	56181630
Hungry bone syndrome	15.65	14.88	4	16349	98	56275616
Oesophageal mucosal tear	15.60	14.88	3	16350	18	56275696
Autoimmune pancytopenia	15.57	14.88	4	16349	100	56275614
Retinal haemorrhage	15.47	14.88	12	16341	4679	56271035
Immobilisation syndrome	15.37	14.88	5	16348	293	56275421
Feeling abnormal	15.28	14.88	10	16343	133592	56142122
Calculus urinary	15.14	14.88	7	16346	1058	56274656
Wound	15.06	14.88	11	16342	138793	56136921

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hypocalcaemia	139.30	17.57	79	7647	21899	31667719
Shunt stenosis	134.26	17.57	32	7694	701	31688917
Shunt occlusion	110.26	17.57	28	7698	803	31688815
Oesophageal perforation	91.30	17.57	25	7701	965	31688653
Soft tissue mass	86.00	17.57	23	7703	811	31688807
Multimorbidity	83.78	17.57	22	7704	722	31688896
Immunosuppressant drug level increased	78.64	17.57	34	7692	5251	31684367
Superinfection	63.84	17.57	23	7703	2195	31687423
Transplant failure	63.07	17.57	25	7701	3101	31686517
Myocardial ischaemia	51.10	17.57	38	7688	16629	31672989
Inflammatory marker increased	49.75	17.57	23	7703	4155	31685463
Labelled drug-drug interaction medication error	49.53	17.57	34	7692	13129	31676489
Renal impairment	48.10	17.57	80	7646	86269	31603349
Osteonecrosis of jaw	48.08	17.57	37	7689	17034	31672584
Oesophageal carcinoma	45.84	17.57	27	7699	8006	31681612
Hepatic function abnormal	45.30	17.57	53	7673	41169	31648449
Lung consolidation	43.85	17.57	23	7703	5450	31684168
Upper respiratory tract inflammation	43.02	17.57	16	7710	1670	31687948
Procalcitonin abnormal	41.59	17.57	11	7715	371	31689247
Cardiomegaly	37.88	17.57	30	7696	14395	31675223
Drug level increased	34.78	17.57	33	7693	20153	31669465
Aplasia pure red cell	34.63	17.57	20	7706	5717	31683901
Rales	34.12	17.57	23	7703	8616	31681002
Encephalomalacia	32.92	17.57	11	7715	838	31688780
Anti-erythropoietin antibody negative	32.43	17.57	8	7718	203	31689415
Neuromyopathy	31.36	17.57	11	7715	970	31688648
Drug ineffective	30.52	17.57	31	7695	395542	31294076
Hypercalcaemia	30.24	17.57	26	7700	13974	31675644
Calciphylaxis	30.22	17.57	11	7715	1080	31688538
C-reactive protein increased	26.94	17.57	45	7681	48605	31641013
PO2 decreased	26.61	17.57	11	7715	1518	31688100
Device related sepsis	26.25	17.57	13	7713	2731	31686887
Retinopathy hypertensive	25.56	17.57	7	7719	270	31689348
PCO2 decreased	25.50	17.57	11	7715	1687	31687931
Cerebral infarction	24.61	17.57	31	7695	25946	31663672
Pleural effusion	23.99	17.57	55	7671	74865	31614753
Fatigue	23.91	17.57	28	7698	335178	31354440
Renal tubular acidosis	22.98	17.57	11	7715	2146	31687472
Interstitial lung disease	22.98	17.57	48	7678	61355	31628263
Drug interaction	22.93	17.57	106	7620	208437	31481181
Lymphocyte count increased	22.65	17.57	12	7714	2901	31686717
Hungry bone syndrome	21.95	17.57	5	7721	89	31689529
Nephrotic syndrome	21.53	17.57	16	7710	6987	31682631
Dysphagia	21.48	17.57	45	7681	57631	31631987
Ascites	21.47	17.57	37	7689	40976	31648642
Extraskeletal ossification	20.85	17.57	4	7722	29	31689589
Monocyte count increased	20.75	17.57	13	7713	4302	31685316
Hepatosplenomegaly neonatal	19.70	17.57	4	7722	40	31689578
Lower respiratory tract infection	19.63	17.57	29	7697	28208	31661410
Bradycardia foetal	19.46	17.57	6	7720	353	31689265
Myeloperoxidase deficiency	19.35	17.57	4	7722	44	31689574
Acute kidney injury	19.16	17.57	125	7601	279589	31410029
Immune thrombocytopenia	18.79	17.57	16	7710	8482	31681136
Disseminated intravascular coagulation	18.65	17.57	24	7702	20513	31669105
Peripheral arterial occlusive disease	18.24	17.57	13	7713	5320	31684298
Hyperkalaemia	18.17	17.57	45	7681	64306	31625312
Haemoptysis	18.11	17.57	30	7696	32159	31657459
Pneumonia	17.85	17.57	141	7585	335171	31354447
Nail discolouration	17.70	17.57	7	7719	862	31688756

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hypocalcaemia	270.99	13.03	170	21687	44689	70861898
Shunt stenosis	205.89	13.03	53	21804	1259	70905328
Muscle spasticity	189.31	13.03	101	21756	19588	70886999
Ear pain	162.60	13.03	103	21754	27496	70879091
Respiratory disorder	147.70	13.03	111	21746	39012	70867575
Shunt occlusion	141.23	13.03	40	21817	1375	70905212
Body temperature increased	137.16	13.03	107	21750	39727	70866860
Night sweats	136.86	13.03	111	21746	43573	70863014
Upper respiratory tract inflammation	126.08	13.03	47	21810	3895	70902692
Hypercalcaemia	121.94	13.03	94	21763	34291	70872296
Osteonecrosis of jaw	121.76	13.03	101	21756	40901	70865686
Hepatic function abnormal	119.45	13.03	125	21732	67871	70838716
Renal impairment	107.20	13.03	173	21684	143764	70762823
Spinal compression fracture	99.04	13.03	61	21796	15492	70891095
Drug ineffective	88.46	13.03	96	21761	939656	69966931
Oesophageal perforation	82.06	13.03	26	21831	1318	70905269
Lower respiratory tract infection	75.87	13.03	129	21728	111784	70794803
Soft tissue mass	70.39	13.03	22	21835	1066	70905521
Fatigue	67.16	13.03	94	21763	824225	70082362
Multimorbidity	64.54	13.03	21	21836	1160	70905427
Immunosuppressant drug level increased	63.41	13.03	36	21821	7871	70898716
Blood parathyroid hormone increased	59.79	13.03	26	21831	3211	70903376
Interstitial lung disease	53.68	13.03	107	21750	104578	70802009
Cerebral infarction	53.27	13.03	66	21791	42943	70863644
Transplant failure	50.86	13.03	25	21832	4082	70902505
Aplasia pure red cell	49.70	13.03	30	21827	7344	70899243
Urticaria	47.85	13.03	134	21723	162915	70743672
Superinfection	44.46	13.03	23	21834	4183	70902404
Insomnia	43.72	13.03	157	21700	217649	70688938
Incorrect route of product administration	43.47	13.03	47	21810	26445	70880142
Hyperuricaemia	41.10	13.03	31	21826	10935	70895652
Product dose omission issue	40.02	13.03	9	21848	217459	70689128
Platelet count decreased	39.70	13.03	133	21724	178089	70728498
Peripheral arterial occlusive disease	39.23	13.03	26	21831	7483	70899104
Procalcitonin abnormal	38.98	13.03	11	21846	373	70906214
Drug intolerance	38.34	13.03	11	21846	225676	70680911
Labelled drug-drug interaction medication error	36.46	13.03	41	21816	24086	70882501
Hungry bone syndrome	36.19	13.03	9	21848	185	70906402
Back pain	35.92	13.03	172	21685	270980	70635607
Tetany	34.89	13.03	16	21841	2238	70904349
Disseminated intravascular coagulation	34.49	13.03	47	21810	33551	70873036
Drug hypersensitivity	34.44	13.03	19	21838	262440	70644147
Inflammatory marker increased	34.28	13.03	26	21831	9248	70897339
Oesophageal carcinoma	34.05	13.03	26	21831	9340	70897247
Anaemia	33.04	13.03	225	21632	403198	70503389
Myocardial ischaemia	33	13.03	39	21818	24161	70882426
Diarrhoea	32.89	13.03	377	21480	782964	70123623
Completed suicide	31.96	13.03	15	21842	227120	70679467
Large intestine polyp	31.43	13.03	27	21830	11449	70895138
Calciphylaxis	31.09	13.03	17	21840	3456	70903131
Gastroenteritis	31.04	13.03	43	21814	31170	70875417
Enteritis infectious	29.76	13.03	16	21841	3146	70903441
Abdominal pain upper	29.48	13.03	128	21729	193474	70713113
Nausea	29.45	13.03	149	21708	851939	70054648
Rheumatoid arthritis	29.34	13.03	28	21829	291777	70614810
Anti-erythropoietin antibody negative	27.97	13.03	8	21849	285	70906302
Lung consolidation	27.90	13.03	22	21835	8284	70898303
Lymph node palpable	27.87	13.03	7	21850	150	70906437
Pruritus	27.84	13.03	192	21665	345368	70561219
Pneumonia aspiration	27.62	13.03	60	21797	62229	70844358
Periodontitis	27.61	13.03	17	21840	4311	70902276
Cardiac failure	27.53	13.03	102	21755	143439	70763148
Hyperhidrosis	27.32	13.03	4	21853	131582	70775005
Encephalomalacia	26.82	13.03	11	21846	1175	70905412
Atypical femur fracture	25.86	13.03	17	21840	4826	70901761
Hyperphosphataemia	25.27	13.03	16	21841	4260	70902327
Neuromyopathy	24.58	13.03	11	21846	1454	70905133
Toxoplasmosis	23.98	13.03	13	21844	2597	70903990
Anxiety	23.50	13.03	20	21837	220310	70686277
Beta 2 microglobulin urine increased	23.49	13.03	6	21851	138	70906449
Peritonitis	23.01	13.03	34	21823	26125	70880462
Sinusitis	22.86	13.03	108	21749	169087	70737500
Enterocolitis viral	22.09	13.03	7	21850	355	70906232
Iron deficiency anaemia	21.77	13.03	31	21826	23041	70883546
Hypophosphataemia	21.75	13.03	26	21831	16300	70890287
Premature rupture of membranes	21.59	13.03	14	21843	3884	70902703
Liver disorder	21.48	13.03	54	21803	61514	70845073
Nephrotic syndrome	21.28	13.03	21	21836	10619	70895968
Immobilisation syndrome	20.67	13.03	7	21850	438	70906149
Osteomyelitis	20.58	13.03	35	21822	30283	70876304
Rash	20.58	13.03	244	21613	510318	70396269
Intentional overdose	20.41	13.03	3	21854	98432	70808155
Cardiomegaly	20.31	13.03	31	21826	24514	70882073
Pharyngitis	20.18	13.03	28	21829	20323	70886264
Retinopathy hypertensive	20.12	13.03	7	21850	475	70906112
Milk-alkali syndrome	20.01	13.03	9	21848	1204	70905383
Vomiting	19.91	13.03	274	21583	592837	70313750
Oncocytoma	19.79	13.03	4	21853	30	70906557
Treatment failure	19.54	13.03	10	21847	144132	70762455
Death	19.43	13.03	86	21771	509975	70396612
Enterocolitis	19.39	13.03	22	21835	13044	70893543
Decreased appetite	19.26	13.03	160	21697	304620	70601967
Haemodialysis complication	19.03	13.03	6	21851	299	70906288
Hyperparathyroidism secondary	18.79	13.03	11	21846	2547	70904040
Immune thrombocytopenia	18.54	13.03	24	21833	16300	70890287
Renal tubular acidosis	18.36	13.03	12	21845	3374	70903213
PO2 decreased	17.81	13.03	11	21846	2803	70903784
Premature delivery	17.76	13.03	27	21830	21277	70885310
Injection site pain	17.75	13.03	7	21850	117612	70788975
Chronic gastritis	17.65	13.03	12	21845	3601	70902986
Nephrogenic anaemia	17.63	13.03	12	21845	3606	70902981
Neuropsychiatric lupus	17.45	13.03	5	21852	179	70906408
PCO2 decreased	17.15	13.03	11	21846	2993	70903594
Abdominal discomfort	16.86	13.03	25	21832	214633	70691954
Calcium metabolism disorder	16.86	13.03	4	21853	67	70906520
Hypotension	16.75	13.03	66	21791	404315	70502272
Pyrexia	16.69	13.03	271	21586	606681	70299906
Pneumonia bacterial	16.65	13.03	23	21834	16618	70889969
Hyperkalaemia	16.61	13.03	71	21786	106520	70800067
Infusion related reaction	16.52	13.03	22	21835	197512	70709075
Skin erosion	16.50	13.03	12	21845	4004	70902583
Colon cancer	16.20	13.03	21	21836	14285	70892302
Rales	16.13	13.03	23	21834	17112	70889475
Pain in extremity	15.96	13.03	50	21807	328032	70578555
Haemoptysis	15.77	13.03	43	21814	51409	70855178
Oesophageal mucosal tear	15.72	13.03	3	21854	16	70906571
Shunt malfunction	15.71	13.03	5	21852	257	70906330
Marasmus	15.67	13.03	7	21850	921	70905666
Concomitant disease aggravated	15.66	13.03	19	21838	12095	70894492
Ascites	15.54	13.03	51	21806	67496	70839091
Haemorrhage subcutaneous	15.26	13.03	12	21845	4497	70902090
C-reactive protein increased	15.25	13.03	71	21786	110446	70796141
Feeling abnormal	15.07	13.03	13	21844	142306	70764281
Drug level increased	14.89	13.03	34	21823	36435	70870152
Depression	14.84	13.03	24	21833	198950	70707637
Weight increased	14.77	13.03	33	21824	242298	70664289
Cholangitis	14.74	13.03	18	21839	11531	70895056
Device related sepsis	14.73	13.03	13	21844	5715	70900872
Chronic obstructive pulmonary disease	14.71	13.03	3	21854	77638	70828949
Precocious puberty	14.67	13.03	5	21852	319	70906268
Loss of personal independence in daily activities	14.66	13.03	4	21853	84906	70821681
Community acquired infection	14.46	13.03	3	21854	26	70906561
Protein urine present	14.19	13.03	16	21841	9424	70897163
Sepsis	14.19	13.03	126	21731	244419	70662168
Pneumonia	14.14	13.03	260	21597	595972	70310615
Osteoporosis	14.13	13.03	40	21817	48867	70857720
Shunt aneurysm	14.07	13.03	3	21854	30	70906557
Hypoglycaemia	14.05	13.03	62	21795	94302	70812285
Ileus	13.91	13.03	26	21831	24211	70882376
Musculoskeletal stiffness	13.90	13.03	15	21842	147745	70758842
Alopecia	13.83	13.03	25	21832	198465	70708122
Myeloperoxidase deficiency	13.81	13.03	3	21854	33	70906554
Neurosis	13.61	13.03	5	21852	397	70906190
Lymphocyte count increased	13.58	13.03	12	21845	5284	70901303
Pemphigoid	13.46	13.03	19	21838	14003	70892584
Dermatophytosis of nail	13.30	13.03	4	21853	170	70906417
Arthropathy	13.28	13.03	16	21841	150041	70756546
Suicide attempt	13.26	13.03	4	21853	79506	70827081
Stag horn calculus	13.26	13.03	4	21853	172	70906415
Pyelonephritis acute	13.15	13.03	12	21845	5505	70901082
Calculus urinary	13.04	13.03	8	21849	2016	70904571

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A11CC03	ALIMENTARY TRACT AND METABOLISM VITAMINS VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO Vitamin D and analogues
ATC	M05BB06	MUSCULO-SKELETAL SYSTEM DRUGS FOR TREATMENT OF BONE DISEASES DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION Bisphosphonates, combinations
MeSH PA	D050071	Bone Density Conservation Agents
CHEBI has role	CHEBI:50646	antiosteoporotic

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Renal osteodystrophy	indication	16726004	DOID:13068
Hypoparathyroidism	indication	36976004	DOID:11199
Hyperparathyroidism	indication	66999008	DOID:13543
Neonatal hypocalcemia	indication	268846006

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	13.7	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Vitamin D3 receptor	Nuclear hormone receptor	P11473	VDR_HUMAN	AGONIST				WOMBAT-PK	KEGG DRUG
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN		Ki	6		DRUG MATRIX

External reference:

ID	Source
D01518	KEGG_DRUG
12062	RXNORM
C0044410	UMLSCUI
CHEBI:31186	CHEBI
M9B	PDB_CHEM_ID
CHEMBL1601669	ChEMBL_ID
DB01436	DRUGBANK_ID
C008088	MESH_SUPPLEMENTAL_RECORD_UI
5282181	PUBCHEM_CID
4489	INN_ID
URQ2517572	UNII
003501	NDDF
11984007	SNOMEDCT_US
329325000	SNOMEDCT_US

Pharmaceutical products:

None