alfacalcidol ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
Vitamin D analogues/derivatives 130 41294-56-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • alfacalcidol
  • 1alpha-Hydroxycholecalciferol
  • alfarol
  • alphacalcidol
  • einsalpha
  • alpha-calcidol
  • 1-hydroxycholecalciferol
  • Molecular weight: 400.65
  • Formula: C27H44O2
  • CLOGP: 8.24
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 2
  • TPSA: 40.46
  • ALOGS: -5.39
  • ROTB: 6

Drug dosage:

DoseUnitRoute
1 mcg O
1 mcg P
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 8 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.00 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 71 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
CL (Clearance) 0.82 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 48.60 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1978 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Muscle spasticity 458.93 14.88 184 16169 19776 56255938
Respiratory disorder 397.81 14.88 195 16158 33762 56241952
Ear pain 390.83 14.88 187 16166 30703 56245011
Body temperature increased 366.65 14.88 185 16168 34057 56241657
Night sweats 362.13 14.88 195 16158 41018 56234696
Hypocalcaemia 177.06 14.88 108 16245 28652 56247062
Urticaria 169.12 14.88 209 16144 144467 56131247
Lower respiratory tract infection 166.03 14.88 185 16168 114609 56161105
Insomnia 141.40 14.88 222 16131 191638 56084076
Back pain 126.81 14.88 238 16115 236932 56038782
Abdominal pain upper 117.26 14.88 196 16157 178117 56097597
Sinusitis 101.46 14.88 195 16158 197386 56078328
Hypercalcaemia 99.50 14.88 72 16281 25339 56250375
Pruritus 95.77 14.88 253 16100 316370 55959344
Peripheral swelling 92.77 14.88 208 16145 234518 56041196
Upper respiratory tract inflammation 90.18 14.88 32 16321 2445 56273269
Hepatic function abnormal 83.99 14.88 74 16279 34484 56241230
Shunt stenosis 83.07 14.88 21 16332 492 56275222
Osteonecrosis of jaw 80.20 14.88 71 16282 33287 56242427
Spinal compression fracture 79.96 14.88 49 16304 13085 56262629
Renal impairment 79.10 14.88 107 16246 80606 56195108
Drug ineffective 78.99 14.88 91 16262 918898 55356816
Asthenia 68.59 14.88 237 16116 342736 55932978
Vomiting 66.37 14.88 303 16050 497925 55777789
Incorrect route of product administration 58.58 14.88 49 16304 21280 56254434
Diarrhoea 57.91 14.88 349 16004 638158 55637556
Fatigue 54.66 14.88 91 16262 788461 55487253
Rheumatoid arthritis 53.76 14.88 22 16331 382582 55893132
Rash 52.87 14.88 282 16071 492765 55782949
Joint swelling 51.67 14.88 193 16160 289607 55986107
Drug intolerance 46.67 14.88 10 16343 264808 56010906
Product dose omission issue 44.78 14.88 4 16349 204749 56070965
Blood parathyroid hormone increased 41.02 14.88 19 16334 2886 56272828
Drug hypersensitivity 39.98 14.88 15 16338 275190 56000524
Shunt occlusion 38.96 14.88 12 16341 588 56275126
Atypical femur fracture 36.38 14.88 21 16332 5026 56270688
Interstitial lung disease 33.82 14.88 60 16293 57003 56218711
Nausea 33.74 14.88 112 16241 764066 55511648
Hyperuricaemia 33.64 14.88 20 16333 5053 56270661
Tetany 33.39 14.88 14 16339 1678 56274036
Alopecia 32.24 14.88 23 16330 293435 55982279
Cerebral infarction 31.98 14.88 36 16317 22469 56253245
Toxoplasmosis 31.91 14.88 13 16340 1449 56274265
Abdominal discomfort 31.43 14.88 21 16332 277253 55998461
Enteritis infectious 31.11 14.88 14 16339 1990 56273724
Lymph node palpable 31.08 14.88 7 16346 98 56275616
Cardiac failure 29.29 14.88 70 16283 82023 56193691
Large intestine polyp 28.46 14.88 21 16332 7606 56268108
Headache 27.98 14.88 266 16087 558778 55716936
Iron deficiency anaemia 27.77 14.88 30 16323 17889 56257825
Anxiety 25.67 14.88 12 16341 193160 56082554
Milk-alkali syndrome 25.34 14.88 9 16344 689 56275025
Gastroenteritis 24.85 14.88 33 16320 24379 56251335
Arthropathy 24.30 14.88 14 16339 200261 56075453
Toxicity to various agents 24.13 14.88 18 16335 224546 56051168
Death 23.89 14.88 39 16314 341387 55934327
Beta 2 microglobulin urine increased 23.66 14.88 5 16348 51 56275663
Treatment failure 23.55 14.88 10 16343 170382 56105332
Osteomyelitis 23.40 14.88 32 16321 24314 56251400
Nephrogenic anaemia 22.45 14.88 11 16342 1893 56273821
Periodontitis 22.37 14.88 13 16340 3150 56272564
Anaemia 22.05 14.88 143 16210 267368 56008346
Haemodialysis complication 21.80 14.88 6 16347 197 56275517
Peritonitis 21.47 14.88 25 16328 16177 56259537
Calciphylaxis 21.25 14.88 12 16341 2755 56272959
Oncocytoma 21.10 14.88 4 16349 22 56275692
Glossodynia 20.99 14.88 9 16344 152449 56123265
Enterocolitis viral 20.80 14.88 6 16347 234 56275480
Platelet count decreased 20.71 14.88 73 16280 106310 56169404
Peripheral arterial occlusive disease 20.01 14.88 13 16340 3837 56271877
Premature rupture of membranes 19.78 14.88 14 16339 4751 56270963
Immunosuppressant drug level increased 19.45 14.88 12 16341 3241 56272473
Ileus 19.37 14.88 22 16331 13860 56261854
Pneumonia aspiration 19.09 14.88 34 16319 32377 56243337
Pemphigus 19.05 14.88 11 16342 157201 56118513
Enterocolitis 18.84 14.88 16 16337 7088 56268626
Infusion related reaction 18.54 14.88 20 16333 208911 56066803
Hand deformity 18.41 14.88 8 16345 134484 56141230
Musculoskeletal stiffness 17.41 14.88 12 16341 155995 56119719
Neuropsychiatric lupus 17.38 14.88 5 16348 193 56275521
Precocious puberty 16.80 14.88 5 16348 218 56275496
Marasmus 16.69 14.88 6 16347 476 56275238
Community acquired infection 16.61 14.88 3 16350 12 56275702
Colon cancer 16.58 14.88 17 16336 9544 56266170
Disseminated intravascular coagulation 16.42 14.88 23 16330 17862 56257852
Blood albumin decreased 16.36 14.88 20 16333 13608 56262106
Product monitoring error 16.33 14.88 11 16342 3448 56272266
Neurosis 16.23 14.88 5 16348 245 56275469
Hyperphosphataemia 16.10 14.88 9 16344 2026 56273688
Pharyngitis 15.79 14.88 23 16330 18515 56257199
Hyperhidrosis 15.66 14.88 4 16349 94084 56181630
Hungry bone syndrome 15.65 14.88 4 16349 98 56275616
Oesophageal mucosal tear 15.60 14.88 3 16350 18 56275696
Autoimmune pancytopenia 15.57 14.88 4 16349 100 56275614
Retinal haemorrhage 15.47 14.88 12 16341 4679 56271035
Immobilisation syndrome 15.37 14.88 5 16348 293 56275421
Feeling abnormal 15.28 14.88 10 16343 133592 56142122
Calculus urinary 15.14 14.88 7 16346 1058 56274656
Wound 15.06 14.88 11 16342 138793 56136921

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypocalcaemia 139.30 17.57 79 7647 21899 31667719
Shunt stenosis 134.26 17.57 32 7694 701 31688917
Shunt occlusion 110.26 17.57 28 7698 803 31688815
Oesophageal perforation 91.30 17.57 25 7701 965 31688653
Soft tissue mass 86.00 17.57 23 7703 811 31688807
Multimorbidity 83.78 17.57 22 7704 722 31688896
Immunosuppressant drug level increased 78.64 17.57 34 7692 5251 31684367
Superinfection 63.84 17.57 23 7703 2195 31687423
Transplant failure 63.07 17.57 25 7701 3101 31686517
Myocardial ischaemia 51.10 17.57 38 7688 16629 31672989
Inflammatory marker increased 49.75 17.57 23 7703 4155 31685463
Labelled drug-drug interaction medication error 49.53 17.57 34 7692 13129 31676489
Renal impairment 48.10 17.57 80 7646 86269 31603349
Osteonecrosis of jaw 48.08 17.57 37 7689 17034 31672584
Oesophageal carcinoma 45.84 17.57 27 7699 8006 31681612
Hepatic function abnormal 45.30 17.57 53 7673 41169 31648449
Lung consolidation 43.85 17.57 23 7703 5450 31684168
Upper respiratory tract inflammation 43.02 17.57 16 7710 1670 31687948
Procalcitonin abnormal 41.59 17.57 11 7715 371 31689247
Cardiomegaly 37.88 17.57 30 7696 14395 31675223
Drug level increased 34.78 17.57 33 7693 20153 31669465
Aplasia pure red cell 34.63 17.57 20 7706 5717 31683901
Rales 34.12 17.57 23 7703 8616 31681002
Encephalomalacia 32.92 17.57 11 7715 838 31688780
Anti-erythropoietin antibody negative 32.43 17.57 8 7718 203 31689415
Neuromyopathy 31.36 17.57 11 7715 970 31688648
Drug ineffective 30.52 17.57 31 7695 395542 31294076
Hypercalcaemia 30.24 17.57 26 7700 13974 31675644
Calciphylaxis 30.22 17.57 11 7715 1080 31688538
C-reactive protein increased 26.94 17.57 45 7681 48605 31641013
PO2 decreased 26.61 17.57 11 7715 1518 31688100
Device related sepsis 26.25 17.57 13 7713 2731 31686887
Retinopathy hypertensive 25.56 17.57 7 7719 270 31689348
PCO2 decreased 25.50 17.57 11 7715 1687 31687931
Cerebral infarction 24.61 17.57 31 7695 25946 31663672
Pleural effusion 23.99 17.57 55 7671 74865 31614753
Fatigue 23.91 17.57 28 7698 335178 31354440
Renal tubular acidosis 22.98 17.57 11 7715 2146 31687472
Interstitial lung disease 22.98 17.57 48 7678 61355 31628263
Drug interaction 22.93 17.57 106 7620 208437 31481181
Lymphocyte count increased 22.65 17.57 12 7714 2901 31686717
Hungry bone syndrome 21.95 17.57 5 7721 89 31689529
Nephrotic syndrome 21.53 17.57 16 7710 6987 31682631
Dysphagia 21.48 17.57 45 7681 57631 31631987
Ascites 21.47 17.57 37 7689 40976 31648642
Extraskeletal ossification 20.85 17.57 4 7722 29 31689589
Monocyte count increased 20.75 17.57 13 7713 4302 31685316
Hepatosplenomegaly neonatal 19.70 17.57 4 7722 40 31689578
Lower respiratory tract infection 19.63 17.57 29 7697 28208 31661410
Bradycardia foetal 19.46 17.57 6 7720 353 31689265
Myeloperoxidase deficiency 19.35 17.57 4 7722 44 31689574
Acute kidney injury 19.16 17.57 125 7601 279589 31410029
Immune thrombocytopenia 18.79 17.57 16 7710 8482 31681136
Disseminated intravascular coagulation 18.65 17.57 24 7702 20513 31669105
Peripheral arterial occlusive disease 18.24 17.57 13 7713 5320 31684298
Hyperkalaemia 18.17 17.57 45 7681 64306 31625312
Haemoptysis 18.11 17.57 30 7696 32159 31657459
Pneumonia 17.85 17.57 141 7585 335171 31354447
Nail discolouration 17.70 17.57 7 7719 862 31688756

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypocalcaemia 270.99 13.03 170 21687 44689 70861898
Shunt stenosis 205.89 13.03 53 21804 1259 70905328
Muscle spasticity 189.31 13.03 101 21756 19588 70886999
Ear pain 162.60 13.03 103 21754 27496 70879091
Respiratory disorder 147.70 13.03 111 21746 39012 70867575
Shunt occlusion 141.23 13.03 40 21817 1375 70905212
Body temperature increased 137.16 13.03 107 21750 39727 70866860
Night sweats 136.86 13.03 111 21746 43573 70863014
Upper respiratory tract inflammation 126.08 13.03 47 21810 3895 70902692
Hypercalcaemia 121.94 13.03 94 21763 34291 70872296
Osteonecrosis of jaw 121.76 13.03 101 21756 40901 70865686
Hepatic function abnormal 119.45 13.03 125 21732 67871 70838716
Renal impairment 107.20 13.03 173 21684 143764 70762823
Spinal compression fracture 99.04 13.03 61 21796 15492 70891095
Drug ineffective 88.46 13.03 96 21761 939656 69966931
Oesophageal perforation 82.06 13.03 26 21831 1318 70905269
Lower respiratory tract infection 75.87 13.03 129 21728 111784 70794803
Soft tissue mass 70.39 13.03 22 21835 1066 70905521
Fatigue 67.16 13.03 94 21763 824225 70082362
Multimorbidity 64.54 13.03 21 21836 1160 70905427
Immunosuppressant drug level increased 63.41 13.03 36 21821 7871 70898716
Blood parathyroid hormone increased 59.79 13.03 26 21831 3211 70903376
Interstitial lung disease 53.68 13.03 107 21750 104578 70802009
Cerebral infarction 53.27 13.03 66 21791 42943 70863644
Transplant failure 50.86 13.03 25 21832 4082 70902505
Aplasia pure red cell 49.70 13.03 30 21827 7344 70899243
Urticaria 47.85 13.03 134 21723 162915 70743672
Superinfection 44.46 13.03 23 21834 4183 70902404
Insomnia 43.72 13.03 157 21700 217649 70688938
Incorrect route of product administration 43.47 13.03 47 21810 26445 70880142
Hyperuricaemia 41.10 13.03 31 21826 10935 70895652
Product dose omission issue 40.02 13.03 9 21848 217459 70689128
Platelet count decreased 39.70 13.03 133 21724 178089 70728498
Peripheral arterial occlusive disease 39.23 13.03 26 21831 7483 70899104
Procalcitonin abnormal 38.98 13.03 11 21846 373 70906214
Drug intolerance 38.34 13.03 11 21846 225676 70680911
Labelled drug-drug interaction medication error 36.46 13.03 41 21816 24086 70882501
Hungry bone syndrome 36.19 13.03 9 21848 185 70906402
Back pain 35.92 13.03 172 21685 270980 70635607
Tetany 34.89 13.03 16 21841 2238 70904349
Disseminated intravascular coagulation 34.49 13.03 47 21810 33551 70873036
Drug hypersensitivity 34.44 13.03 19 21838 262440 70644147
Inflammatory marker increased 34.28 13.03 26 21831 9248 70897339
Oesophageal carcinoma 34.05 13.03 26 21831 9340 70897247
Anaemia 33.04 13.03 225 21632 403198 70503389
Myocardial ischaemia 33 13.03 39 21818 24161 70882426
Diarrhoea 32.89 13.03 377 21480 782964 70123623
Completed suicide 31.96 13.03 15 21842 227120 70679467
Large intestine polyp 31.43 13.03 27 21830 11449 70895138
Calciphylaxis 31.09 13.03 17 21840 3456 70903131
Gastroenteritis 31.04 13.03 43 21814 31170 70875417
Enteritis infectious 29.76 13.03 16 21841 3146 70903441
Abdominal pain upper 29.48 13.03 128 21729 193474 70713113
Nausea 29.45 13.03 149 21708 851939 70054648
Rheumatoid arthritis 29.34 13.03 28 21829 291777 70614810
Anti-erythropoietin antibody negative 27.97 13.03 8 21849 285 70906302
Lung consolidation 27.90 13.03 22 21835 8284 70898303
Lymph node palpable 27.87 13.03 7 21850 150 70906437
Pruritus 27.84 13.03 192 21665 345368 70561219
Pneumonia aspiration 27.62 13.03 60 21797 62229 70844358
Periodontitis 27.61 13.03 17 21840 4311 70902276
Cardiac failure 27.53 13.03 102 21755 143439 70763148
Hyperhidrosis 27.32 13.03 4 21853 131582 70775005
Encephalomalacia 26.82 13.03 11 21846 1175 70905412
Atypical femur fracture 25.86 13.03 17 21840 4826 70901761
Hyperphosphataemia 25.27 13.03 16 21841 4260 70902327
Neuromyopathy 24.58 13.03 11 21846 1454 70905133
Toxoplasmosis 23.98 13.03 13 21844 2597 70903990
Anxiety 23.50 13.03 20 21837 220310 70686277
Beta 2 microglobulin urine increased 23.49 13.03 6 21851 138 70906449
Peritonitis 23.01 13.03 34 21823 26125 70880462
Sinusitis 22.86 13.03 108 21749 169087 70737500
Enterocolitis viral 22.09 13.03 7 21850 355 70906232
Iron deficiency anaemia 21.77 13.03 31 21826 23041 70883546
Hypophosphataemia 21.75 13.03 26 21831 16300 70890287
Premature rupture of membranes 21.59 13.03 14 21843 3884 70902703
Liver disorder 21.48 13.03 54 21803 61514 70845073
Nephrotic syndrome 21.28 13.03 21 21836 10619 70895968
Immobilisation syndrome 20.67 13.03 7 21850 438 70906149
Osteomyelitis 20.58 13.03 35 21822 30283 70876304
Rash 20.58 13.03 244 21613 510318 70396269
Intentional overdose 20.41 13.03 3 21854 98432 70808155
Cardiomegaly 20.31 13.03 31 21826 24514 70882073
Pharyngitis 20.18 13.03 28 21829 20323 70886264
Retinopathy hypertensive 20.12 13.03 7 21850 475 70906112
Milk-alkali syndrome 20.01 13.03 9 21848 1204 70905383
Vomiting 19.91 13.03 274 21583 592837 70313750
Oncocytoma 19.79 13.03 4 21853 30 70906557
Treatment failure 19.54 13.03 10 21847 144132 70762455
Death 19.43 13.03 86 21771 509975 70396612
Enterocolitis 19.39 13.03 22 21835 13044 70893543
Decreased appetite 19.26 13.03 160 21697 304620 70601967
Haemodialysis complication 19.03 13.03 6 21851 299 70906288
Hyperparathyroidism secondary 18.79 13.03 11 21846 2547 70904040
Immune thrombocytopenia 18.54 13.03 24 21833 16300 70890287
Renal tubular acidosis 18.36 13.03 12 21845 3374 70903213
PO2 decreased 17.81 13.03 11 21846 2803 70903784
Premature delivery 17.76 13.03 27 21830 21277 70885310
Injection site pain 17.75 13.03 7 21850 117612 70788975
Chronic gastritis 17.65 13.03 12 21845 3601 70902986
Nephrogenic anaemia 17.63 13.03 12 21845 3606 70902981
Neuropsychiatric lupus 17.45 13.03 5 21852 179 70906408
PCO2 decreased 17.15 13.03 11 21846 2993 70903594
Abdominal discomfort 16.86 13.03 25 21832 214633 70691954
Calcium metabolism disorder 16.86 13.03 4 21853 67 70906520
Hypotension 16.75 13.03 66 21791 404315 70502272
Pyrexia 16.69 13.03 271 21586 606681 70299906
Pneumonia bacterial 16.65 13.03 23 21834 16618 70889969
Hyperkalaemia 16.61 13.03 71 21786 106520 70800067
Infusion related reaction 16.52 13.03 22 21835 197512 70709075
Skin erosion 16.50 13.03 12 21845 4004 70902583
Colon cancer 16.20 13.03 21 21836 14285 70892302
Rales 16.13 13.03 23 21834 17112 70889475
Pain in extremity 15.96 13.03 50 21807 328032 70578555
Haemoptysis 15.77 13.03 43 21814 51409 70855178
Oesophageal mucosal tear 15.72 13.03 3 21854 16 70906571
Shunt malfunction 15.71 13.03 5 21852 257 70906330
Marasmus 15.67 13.03 7 21850 921 70905666
Concomitant disease aggravated 15.66 13.03 19 21838 12095 70894492
Ascites 15.54 13.03 51 21806 67496 70839091
Haemorrhage subcutaneous 15.26 13.03 12 21845 4497 70902090
C-reactive protein increased 15.25 13.03 71 21786 110446 70796141
Feeling abnormal 15.07 13.03 13 21844 142306 70764281
Drug level increased 14.89 13.03 34 21823 36435 70870152
Depression 14.84 13.03 24 21833 198950 70707637
Weight increased 14.77 13.03 33 21824 242298 70664289
Cholangitis 14.74 13.03 18 21839 11531 70895056
Device related sepsis 14.73 13.03 13 21844 5715 70900872
Chronic obstructive pulmonary disease 14.71 13.03 3 21854 77638 70828949
Precocious puberty 14.67 13.03 5 21852 319 70906268
Loss of personal independence in daily activities 14.66 13.03 4 21853 84906 70821681
Community acquired infection 14.46 13.03 3 21854 26 70906561
Protein urine present 14.19 13.03 16 21841 9424 70897163
Sepsis 14.19 13.03 126 21731 244419 70662168
Pneumonia 14.14 13.03 260 21597 595972 70310615
Osteoporosis 14.13 13.03 40 21817 48867 70857720
Shunt aneurysm 14.07 13.03 3 21854 30 70906557
Hypoglycaemia 14.05 13.03 62 21795 94302 70812285
Ileus 13.91 13.03 26 21831 24211 70882376
Musculoskeletal stiffness 13.90 13.03 15 21842 147745 70758842
Alopecia 13.83 13.03 25 21832 198465 70708122
Myeloperoxidase deficiency 13.81 13.03 3 21854 33 70906554
Neurosis 13.61 13.03 5 21852 397 70906190
Lymphocyte count increased 13.58 13.03 12 21845 5284 70901303
Pemphigoid 13.46 13.03 19 21838 14003 70892584
Dermatophytosis of nail 13.30 13.03 4 21853 170 70906417
Arthropathy 13.28 13.03 16 21841 150041 70756546
Suicide attempt 13.26 13.03 4 21853 79506 70827081
Stag horn calculus 13.26 13.03 4 21853 172 70906415
Pyelonephritis acute 13.15 13.03 12 21845 5505 70901082
Calculus urinary 13.04 13.03 8 21849 2016 70904571

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11CC03 ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO
Vitamin D and analogues
ATC M05BB06 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
MeSH PA D050071 Bone Density Conservation Agents
CHEBI has role CHEBI:50646 antiosteoporotic

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Renal osteodystrophy indication 16726004 DOID:13068
Hypoparathyroidism indication 36976004 DOID:11199
Hyperparathyroidism indication 66999008 DOID:13543
Neonatal hypocalcemia indication 268846006




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.7 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Vitamin D3 receptor Nuclear hormone receptor AGONIST WOMBAT-PK KEGG DRUG
Sodium-dependent noradrenaline transporter Transporter Ki 6 DRUG MATRIX

External reference:

IDSource
D01518 KEGG_DRUG
12062 RXNORM
C0044410 UMLSCUI
CHEBI:31186 CHEBI
M9B PDB_CHEM_ID
CHEMBL1601669 ChEMBL_ID
DB01436 DRUGBANK_ID
C008088 MESH_SUPPLEMENTAL_RECORD_UI
5282181 PUBCHEM_CID
4489 INN_ID
URQ2517572 UNII
003501 NDDF
11984007 SNOMEDCT_US
329325000 SNOMEDCT_US

Pharmaceutical products:

None