DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
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Download
L1000
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All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
glucosamine 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
1307
3416-24-8
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
glucosamine
Molecular weight: 179.17
Formula: C6H13NO5
CLOGP: -2.18
LIPINSKI: 0
HAC: 6
HDO: 5
TPSA: 116.17
ALOGS: 0.49
ROTB: 1
Drug dosage:
Dose
Unit
Route
1.50
g
O
ADMET properties:
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Property
Value
Reference
BA (Bioavailability)
26 %
Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
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Approvals:
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Date
Agency
Company
Orphan
None
FDA
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FDA Adverse Event Reporting System (Female)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Sedation complication
799.50
22.44
298
35173
13524
63440027
Creatinine renal clearance decreased
797.32
22.44
311
35160
15997
63437554
Orthostatic hypotension
710.33
22.44
364
35107
35796
63417755
Sedation
660.70
22.44
355
35116
38454
63415097
Blood calcium decreased
649.47
22.44
310
35161
26141
63427410
Cognitive disorder
638.41
22.44
394
35077
55421
63398130
Balance disorder
482.69
22.44
390
35081
84032
63369519
Depressed level of consciousness
420.22
22.44
317
35154
61761
63391790
Mobility decreased
414.24
22.44
419
35052
120740
63332811
Lip dry
272.80
22.44
145
35326
15325
63438226
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FDA Adverse Event Reporting System (Male)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Milk-alkali syndrome
97.51
19.75
21
4302
584
34952024
Metabolic alkalosis
42.44
19.75
13
4310
1488
34951120
Hypercalcaemia
33.69
19.75
22
4301
15446
34937162
Fatigue
33.51
19.75
111
4212
370542
34582066
Psoriasis
26.24
19.75
28
4295
38784
34913824
HLA marker study positive
24.64
19.75
5
4318
103
34952505
Flatulence
23.30
19.75
20
4303
21178
34931430
Diarrhoea
20.74
19.75
99
4224
389813
34562795
Myalgia
20.44
19.75
37
4286
84073
34868535
Decubitus ulcer
20.19
19.75
13
4310
8908
34943700
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FDA Adverse Event Reporting System (Geriatric)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Sedation complication
855.10
22.70
303
34352
15366
79694367
Creatinine renal clearance decreased
841.67
22.70
315
34340
18687
79691046
Blood calcium decreased
691.07
22.70
317
34338
31502
79678231
Orthostatic hypotension
653.85
22.70
367
34288
55797
79653936
Cognitive disorder
650.42
22.70
395
34260
69531
79640202
Sedation
644.87
22.70
354
34301
51541
79658192
Balance disorder
510.56
22.70
388
34267
98469
79611264
Mobility decreased
476.87
22.70
407
34248
121768
79587965
Depressed level of consciousness
372.91
22.70
320
34335
96332
79613401
Lip dry
295.53
22.70
141
34514
15277
79694456
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FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
M01AX05
MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Other antiinflammatory and antirheumatic agents, non-steroids
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Hyperphosphatemia
contraindication
20165001
DOID:0050459
Hypervitaminosis D
contraindication
27712000
DOID:9971
Sarcoidosis
contraindication
31541009
DOID:11335
Hypertensive disorder
contraindication
38341003
DOID:10763
Hyperlipidemia
contraindication
55822004
DOID:1168
Hypercalcemia
contraindication
66931009
DOID:12678
Diabetes mellitus
contraindication
73211009
DOID:9351
Kidney disease
contraindication
90708001
DOID:557
Kidney stone
contraindication
95570007
Arteriosclerosis obliterans
contraindication
361133006
DOID:5160
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
11.28
acidic
pKa2
12.49
acidic
pKa3
14.0
acidic
pKa4
7.29
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
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ID
Source
004563
NDDF
19221
MMSL
3120
INN_ID
4021359
VUID
4021359
VANDF
408111007
SNOMEDCT_US
439213
PUBCHEM_CID
4845
RXNORM
70237008
SNOMEDCT_US
C0017718
UMLSCUI
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Pharmaceutical products:
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Product
Category
Ingredients
NDC
Form
Quantity
Route
Marketing
Label
Remaxazon External Patch
HUMAN PRESCRIPTION DRUG LABEL
4
69379-285
PATCH
5 g
TOPICAL
unapproved drug other
2 sections
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glucosamine