glimepiride ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antihyperglycaemics 1300 93479-97-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • glimepiride
  • diameprid
  • glimax
  • glimperide
  • glirid
  • Molecular weight: 490.62
  • Formula: C24H34N4O5S
  • CLOGP: 3.96
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 3
  • TPSA: 124.68
  • ALOGS: -4.11
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.00 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.23 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.19 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.01 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 10 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Nov. 30, 1995 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypoglycaemia 1897.74 10.93 904 39881 52677 50511662
Blood glucose increased 516.85 10.93 441 40344 70883 50493456
Lactic acidosis 371.26 10.93 266 40519 33089 50531250
Hypoglycaemic coma 335.55 10.93 109 40676 2224 50562115
Diabetes mellitus inadequate control 237.37 10.93 142 40643 13003 50551336
Glycosylated haemoglobin increased 227.14 10.93 128 40657 10478 50553861
Blood glucose decreased 213.55 10.93 150 40635 18061 50546278
Acute kidney injury 174.44 10.93 489 40296 227569 50336770
Hypoglycaemic encephalopathy 167.63 10.93 40 40745 238 50564101
Hyperglycaemia 134.20 10.93 156 40629 36249 50528090
Drug ineffective 120.53 10.93 306 40479 819027 49745312
Maternal exposure during pregnancy 98.72 10.93 8 40777 159770 50404569
Systemic lupus erythematosus 86.98 10.93 7 40778 140615 50423724
Contraindicated product administered 85.35 10.93 10 40775 148948 50415391
Infusion related reaction 84.40 10.93 17 40768 169540 50394799
Myocardial infarction 81.13 10.93 204 40581 88823 50475516
Diabetic ketoacidosis 80.35 10.93 85 40700 17787 50546552
Pemphigus 80.21 10.93 4 40781 120162 50444177
Joint swelling 79.22 10.93 50 40735 245236 50319103
Pancreatitis 77.50 10.93 130 40655 42484 50521855
Drug intolerance 77.42 10.93 40 40745 219064 50345275
Hyperkalaemia 74.86 10.93 137 40648 47952 50516387
Synovitis 74.33 10.93 7 40778 123858 50440481
Cardiac failure congestive 73.40 10.93 190 40595 84192 50480147
Diabetic metabolic decompensation 71.19 10.93 31 40754 1449 50562890
Glossodynia 68.12 10.93 7 40778 115562 50448777
Cerebral infarction 65.66 10.93 84 40701 21520 50542819
Renal failure 62.86 10.93 209 40576 106424 50457915
Blood glucose fluctuation 62.66 10.93 40 40745 4106 50560233
Exposure during pregnancy 62.62 10.93 11 40774 121004 50443335
Diabetes mellitus 62.05 10.93 128 40657 48905 50515434
Off label use 61.36 10.93 188 40597 474238 50090101
Decreased appetite 58.16 10.93 317 40468 200606 50363733
Rheumatoid arthritis 56.65 10.93 48 40737 202502 50361837
Pancreatic carcinoma 56.64 10.93 44 40741 6170 50558169
Pancreatitis acute 54.88 10.93 81 40704 23731 50540608
Altered state of consciousness 54.09 10.93 77 40708 21833 50542506
Alopecia 49.10 10.93 76 40709 244971 50319368
Coronary artery disease 47.92 10.93 86 40699 29640 50534699
Therapeutic product effect decreased 47.78 10.93 25 40760 136025 50428314
Blood glucose abnormal 47.68 10.93 41 40744 6631 50557708
Neuroglycopenia 46.45 10.93 11 40774 63 50564276
Pericarditis 45.76 10.93 5 40780 78684 50485655
Pain 45.59 10.93 277 40508 578626 49985713
Metabolic acidosis 45.23 10.93 98 40687 38727 50525612
Euglycaemic diabetic ketoacidosis 44.60 10.93 28 40757 2791 50561548
Hypersensitivity 43.80 10.93 66 40719 215095 50349244
Renal impairment 42.54 10.93 146 40639 75515 50488824
MELAS syndrome 41.08 10.93 11 40774 110 50564229
Sopor 39.31 10.93 63 40722 19816 50544523
Cold sweat 38.18 10.93 45 40740 10599 50553740
Loss of consciousness 38.17 10.93 176 40609 104177 50460162
Wound 37.79 10.93 19 40766 105775 50458564
Swelling 37.69 10.93 65 40720 200807 50363532
Postprandial hypoglycaemia 36.97 10.93 9 40776 59 50564280
Dehydration 36.59 10.93 229 40556 152220 50412119
Weight decreased 36.15 10.93 303 40482 220942 50343397
Hyperhidrosis 35.08 10.93 154 40631 89272 50475067
Diarrhoea 34.84 10.93 666 40119 587810 49976529
Bladder cancer 33.47 10.93 25 40760 3307 50561032
Musculoskeletal stiffness 32.87 10.93 33 40752 128448 50435891
Blood creatinine increased 32.85 10.93 135 40650 76025 50488314
Cholelithiasis 32.47 10.93 85 40700 37888 50526451
Treatment failure 32.28 10.93 38 40747 137599 50426740
Cardiac failure 32.18 10.93 134 40651 75906 50488433
Ketoacidosis 32.11 10.93 26 40759 3869 50560470
Insulin C-peptide increased 32.04 10.93 8 40777 59 50564280
Drug hypersensitivity 31.97 10.93 100 40685 250910 50313429
Dermatitis exfoliative 31.57 10.93 29 40756 5113 50559226
Drug interaction 31.34 10.93 271 40514 199350 50364989
Product use issue 31.23 10.93 45 40740 149430 50414909
Fall 31.13 10.93 409 40376 334523 50229816
Abdominal discomfort 30.41 10.93 91 40694 231550 50332789
Blood urea increased 30.33 10.93 62 40723 23523 50540816
Discomfort 29.89 10.93 26 40759 108354 50455985
Arthropathy 29.70 10.93 51 40734 157855 50406484
Helicobacter infection 29.30 10.93 3 40782 49699 50514640
Sinusitis 28.63 10.93 59 40726 170499 50393840
Ketosis 28.61 10.93 12 40773 511 50563828
Thrombotic cerebral infarction 28.55 10.93 8 40777 96 50564243
Anuria 28.47 10.93 40 40745 11204 50553135
Hyperinsulinaemia 28.33 10.93 8 40777 99 50564240
Fatigue 27.71 10.93 403 40382 707198 49857141
Shock hypoglycaemic 27.55 10.93 8 40777 110 50564229
Hypoparathyroidism 27.14 10.93 12 40773 582 50563757
Pyelonephritis acute 26.98 10.93 24 40761 4059 50560280
Nasopharyngitis 26.63 10.93 74 40711 192853 50371486
Diabetic retinopathy 25.42 10.93 18 40767 2192 50562147
Drug level increased 25.19 10.93 51 40734 19217 50545122
Hypoglycaemic unconsciousness 24.90 10.93 12 40773 710 50563629
Hepatic function abnormal 24.78 10.93 70 40715 32611 50531728
Biopsy skin abnormal 24.40 10.93 7 40778 92 50564247
Product use in unapproved indication 24.05 10.93 35 40750 115784 50448555
Restlessness 23.23 10.93 58 40727 25115 50539224
Arthralgia 23.16 10.93 234 40551 438468 50125871
Injection site nodule 22.76 10.93 20 40765 3328 50561011
Rhabdomyolysis 22.53 10.93 76 40709 38951 50525388
Asthenia 21.94 10.93 370 40415 318672 50245667
Rash 21.60 10.93 237 40548 437234 50127105
Diabetic neuropathy 21.56 10.93 20 40765 3571 50560768
Infection 21.24 10.93 70 40715 172884 50391455
Oedema peripheral 21.01 10.93 207 40578 157754 50406585
Hypothermia 20.96 10.93 36 40749 11980 50552359
Cholecystitis 20.92 10.93 39 40746 13832 50550507
Diabetic complication 20.88 10.93 11 40774 787 50563552
Hyperthyroidism 20.62 10.93 36 40749 12139 50552200
Depressed level of consciousness 20.01 10.93 89 40696 51864 50512475
Blood potassium increased 19.79 10.93 42 40743 16356 50547983
Poverty of speech 19.71 10.93 8 40777 313 50564026
Muscle discomfort 19.65 10.93 6 40779 99 50564240
Coagulation test abnormal 19.65 10.93 10 40775 666 50563673
Differential white blood cell count abnormal 19.33 10.93 10 40775 689 50563650
Abortion spontaneous 19.14 10.93 5 40780 41767 50522572
Anaemia vitamin B12 deficiency 18.98 10.93 8 40777 345 50563994
Nausea 18.88 10.93 720 40065 704678 49859661
Medication error 18.84 10.93 68 40717 36036 50528303
Mobility decreased 18.82 10.93 22 40763 79926 50484413
Hyponatraemia 18.61 10.93 137 40648 96002 50468337
Anti-insulin antibody increased 18.24 10.93 5 40780 55 50564284
Bradypnoea 18.22 10.93 17 40768 3057 50561282
Urogenital haemorrhage 18.20 10.93 7 40778 237 50564102
Urine ketone body present 18.03 10.93 15 40770 2318 50562021
Peripheral swelling 18.03 10.93 95 40690 205841 50358498
Blood insulin increased 18.00 10.93 6 40779 133 50564206
Ill-defined disorder 17.80 10.93 11 40774 54643 50509696
Pancreatic carcinoma metastatic 17.62 10.93 14 40771 2028 50562311
Oliguria 17.58 10.93 27 40758 8189 50556150
Retinal haemorrhage 17.49 10.93 20 40765 4561 50559778
Hypomagnesaemia 16.97 10.93 49 40736 23107 50541232
Drug abuse 16.93 10.93 14 40771 59832 50504507
Impaired healing 16.64 10.93 19 40766 69767 50494572
Headache 16.59 10.93 298 40487 506237 50058102
Hyporesponsive to stimuli 16.44 10.93 10 40775 942 50563397
Hyperventilation 16.38 10.93 21 40764 5388 50558951
Irritable bowel syndrome 15.88 10.93 11 40774 51430 50512909
Blood creatine phosphokinase increased 15.80 10.93 52 40733 26315 50538024
Glycosylated haemoglobin abnormal 15.72 10.93 5 40780 95 50564244
Neutropenia 15.46 10.93 64 40721 147901 50416438
Hepatic steatosis 15.43 10.93 49 40736 24335 50540004
Hip arthroplasty 15.23 10.93 3 40782 30426 50533913
Anaemia 14.93 10.93 286 40499 252170 50312169
Pemphigoid 14.93 10.93 21 40764 5886 50558453
Contusion 14.75 10.93 44 40741 112139 50452200
Pregnancy 14.63 10.93 3 40782 29574 50534765
Migraine 14.43 10.93 24 40761 75256 50489083
Vomiting 14.43 10.93 479 40306 460279 50104060
Intentional product use issue 14.31 10.93 25 40760 76893 50487446
Arteriosclerosis 14.29 10.93 26 40759 9051 50555288
Electrolyte imbalance 14.23 10.93 38 40747 17131 50547208
Ectopic ACTH syndrome 14.07 10.93 5 40780 135 50564204
Macular oedema 14.03 10.93 16 40769 3638 50560701
Gastroenteritis 14.02 10.93 46 40739 23235 50541104
Musculoskeletal pain 13.85 10.93 23 40762 72154 50492185
Carotid arteriosclerosis 13.77 10.93 9 40776 962 50563377
Liver disorder 13.76 10.93 63 40722 37159 50527180
Blood triglycerides increased 13.68 10.93 29 40756 11283 50553056
Reperfusion injury 13.65 10.93 4 40781 57 50564282
Hepatic enzyme increased 13.39 10.93 61 40724 137319 50427020
Toxic epidermal necrolysis 13.12 10.93 42 40743 20950 50543389
Hypertriglyceridaemia 13.11 10.93 19 40766 5472 50558867
Foetal exposure during pregnancy 13.07 10.93 3 40782 27356 50536983
Phobia 12.93 10.93 6 40779 326 50564013
Mixed anxiety and depressive disorder 12.90 10.93 5 40780 173 50564166
Lipase increased 12.86 10.93 24 40761 8517 50555822
Azotaemia 12.83 10.93 16 40769 3992 50560347
Metabolic encephalopathy 12.64 10.93 18 40767 5103 50559236
Pylorus dilatation 12.55 10.93 3 40782 18 50564321
Dizziness 12.39 10.93 366 40419 346003 50218336
Metabolic alkalosis 12.29 10.93 13 40772 2718 50561621
Capillary leak syndrome 12.27 10.93 11 40774 1879 50562460
Myocardial ischaemia 12.05 10.93 28 40757 11585 50552754
Completed suicide 12.01 10.93 60 40725 131829 50432510
Glomerular filtration rate decreased 11.98 10.93 28 40757 11624 50552715
Compartment syndrome 11.82 10.93 11 40774 1971 50562368
Angina pectoris 11.74 10.93 47 40738 26141 50538198
Gastrointestinal disorder 11.74 10.93 38 40747 94418 50469921
Jaundice 11.51 10.93 47 40738 26382 50537957
Urinary tract infection 11.33 10.93 248 40537 223772 50340567
Continuous haemodiafiltration 11.30 10.93 8 40777 974 50563365
Blood phosphorus increased 11.11 10.93 12 40773 2570 50561769
Dry eye 11.10 10.93 6 40779 32089 50532250
Hypophagia 11.05 10.93 48 40737 27680 50536659
Adenocarcinoma pancreas 11.01 10.93 8 40777 1014 50563325
Psoriatic arthropathy 11.00 10.93 13 40772 47019 50517320

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypoglycaemia 1521.49 11.08 923 42630 47423 29483551
Blood glucose increased 347.60 11.08 431 43122 58553 29472421
Hypoglycaemic coma 318.81 11.08 120 43433 2043 29528931
Lactic acidosis 263.47 11.08 271 43282 29976 29500998
Diabetes mellitus inadequate control 258.59 11.08 182 43371 11952 29519022
Glycosylated haemoglobin increased 213.99 11.08 147 43406 9279 29521695
Cerebral infarction 138.23 11.08 176 43377 24499 29506475
Pancreatitis 112.91 11.08 191 43362 34323 29496651
Bladder cancer 107.20 11.08 101 43452 10026 29520948
Blood glucose decreased 102.94 11.08 107 43446 11962 29519012
Off label use 102.58 11.08 179 43374 300621 29230353
Pancreatitis acute 100.50 11.08 150 43403 24235 29506739
Myocardial infarction 100.03 11.08 373 43180 109923 29421051
Coronary artery disease 93.24 11.08 203 43350 43987 29486987
Hyperglycaemia 90.71 11.08 173 43380 34114 29496860
Pancreatic carcinoma 82.83 11.08 75 43478 7075 29523899
Cardiac failure congestive 82.31 11.08 274 43279 76307 29454667
Drug abuse 76.13 11.08 13 43540 79870 29451104
Hyperkalaemia 72.60 11.08 227 43326 61165 29469809
Hypoglycaemic encephalopathy 69.27 11.08 23 43530 265 29530709
Interstitial lung disease 67.86 11.08 213 43340 57505 29473469
Diabetic ketoacidosis 64.97 11.08 98 43455 15975 29514999
Product use in unapproved indication 60.63 11.08 26 43527 86849 29444125
Hepatic function abnormal 57.77 11.08 157 43396 39102 29491872
Acute kidney injury 51.71 11.08 607 42946 264660 29266314
Toxicity to various agents 48.26 11.08 116 43437 173545 29357429
Altered state of consciousness 47.30 11.08 96 43457 19793 29511181
Blood lactic acid 46.68 11.08 18 43535 328 29530646
Drug ineffective 45.49 11.08 331 43222 362839 29168135
Diabetes mellitus 44.07 11.08 144 43409 39687 29491287
Neutropenia 40.65 11.08 83 43470 131628 29399346
Pemphigoid 39.19 11.08 52 43501 7529 29523445
Decreased appetite 33.94 11.08 345 43208 144997 29385977
Febrile neutropenia 33.56 11.08 72 43481 112168 29418806
Gastric cancer 33.03 11.08 38 43515 4756 29526218
Renal impairment 32.44 11.08 218 43335 81115 29449859
Diabetic metabolic decompensation 31.93 11.08 22 43531 1394 29529580
Diabetic nephropathy 30.44 11.08 24 43529 1871 29529103
Acute myocardial infarction 29.97 11.08 146 43407 48292 29482682
Diabetic retinopathy 29.48 11.08 22 43531 1580 29529394
Bladder transitional cell carcinoma 28.86 11.08 26 43527 2435 29528539
Liver disorder 28.62 11.08 98 43455 27651 29503323
Hepatocellular carcinoma 28.56 11.08 43 43510 6995 29523979
Dyslalia 28.18 11.08 14 43539 478 29530496
Blood glucose abnormal 28.04 11.08 36 43517 5047 29525927
Urine ketone body present 27.76 11.08 18 43535 1030 29529944
Hypoglycaemic unconsciousness 27.62 11.08 16 43537 747 29530227
Pancreatic carcinoma metastatic 26.63 11.08 26 43527 2695 29528279
Blindness transient 25.97 11.08 22 43531 1898 29529076
Treatment failure 25.84 11.08 11 43542 36928 29494046
Shock 25.13 11.08 79 43474 21325 29509649
Cerebrovascular accident 24.83 11.08 196 43357 76715 29454259
Completed suicide 24.46 11.08 61 43492 90185 29440789
Lipase increased 24.45 11.08 44 43509 8293 29522681
Cardiac failure 23.94 11.08 199 43354 79088 29451886
Death 23.39 11.08 359 43194 341725 29189249
Amylase increased 22.49 11.08 33 43520 5247 29525727
Myocardial ischaemia 22.47 11.08 63 43490 15965 29515009
Blood glucose fluctuation 22.28 11.08 27 43526 3570 29527404
Drug resistance 21.66 11.08 3 43550 21537 29509437
Diabetic neuropathy 21.36 11.08 27 43526 3726 29527248
Joint swelling 21.30 11.08 25 43528 49605 29481369
Mucosal inflammation 21.17 11.08 10 43543 31585 29499389
Lacunar infarction 20.53 11.08 23 43530 2796 29528178
Glycosylated haemoglobin decreased 20.36 11.08 10 43543 333 29530641
Latent autoimmune diabetes in adults 20.36 11.08 6 43547 45 29530929
Coronary artery stenosis 19.93 11.08 41 43512 8532 29522442
Renal failure 19.82 11.08 264 43289 118335 29412639
Brain stem infarction 19.65 11.08 15 43538 1115 29529859
Albumin urine present 19.57 11.08 10 43543 363 29530611
Infusion related reaction 18.94 11.08 22 43531 43864 29487110
Product commingling 18.69 11.08 5 43548 25 29530949
Haemorrhagic cerebral infarction 17.83 11.08 12 43541 731 29530243
Nephrogenic anaemia 17.64 11.08 18 43535 1967 29529007
Blood urea increased 17.57 11.08 85 43468 28027 29502947
Cholangiocarcinoma 17.38 11.08 13 43540 937 29530037
Blood lactate dehydrogenase increased 17.38 11.08 65 43488 19144 29511830
Ischaemic cardiomyopathy 16.85 11.08 30 43523 5608 29525366
Lower respiratory tract infection 16.84 11.08 9 43544 26493 29504481
Hypothermia 16.75 11.08 40 43513 9199 29521775
Intentional product use issue 16.58 11.08 23 43530 42475 29488499
Pyrexia 16.33 11.08 312 43241 287310 29243664
Blood creatinine increased 16.15 11.08 194 43359 84908 29446066
Cytomegalovirus infection 16.09 11.08 7 43546 23208 29507766
Hyperglycaemic hyperosmolar nonketotic syndrome 16.01 11.08 13 43540 1057 29529917
Oedema peripheral 15.86 11.08 227 43326 103330 29427644
Blood triglycerides increased 15.65 11.08 48 43505 12786 29518188
Diabetic gangrene 15.61 11.08 7 43546 189 29530785
Product use issue 15.36 11.08 33 43520 51411 29479563
Angina pectoris 15.16 11.08 81 43472 27769 29503205
Aggression 15.14 11.08 18 43535 35523 29495451
Arteriosclerosis 15.06 11.08 41 43512 10215 29520759
Thrombotic cerebral infarction 15.03 11.08 8 43545 316 29530658
Metabolic acidosis 15.03 11.08 101 43452 37561 29493413
Colon cancer 14.81 11.08 34 43519 7621 29523353
Loss of consciousness 14.57 11.08 170 43383 73886 29457088
COVID-19 14.55 11.08 19 43534 35995 29494979
Cardiovascular disorder 14.42 11.08 37 43516 8898 29522076
Hyperlipidaemia 14.35 11.08 46 43507 12544 29518430
Arthralgia 14.30 11.08 134 43419 139483 29391491
Product odour abnormal 14.22 11.08 10 43543 655 29530319
Anti-insulin antibody increased 14.05 11.08 5 43548 72 29530902
Weight decreased 13.87 11.08 305 43248 150600 29380374
Hyperuricaemia 13.78 11.08 31 43522 6858 29524116
Cardiac disorder 13.73 11.08 98 43455 37165 29493809
Insulin resistance 13.73 11.08 9 43544 525 29530449
Euglycaemic diabetic ketoacidosis 13.53 11.08 18 43535 2612 29528362
Hospitalisation 13.31 11.08 30 43523 45958 29485016
Gastric adenoma 13.28 11.08 3 43550 6 29530968
Headache 13.10 11.08 179 43374 173828 29357146
Ketonuria 13.05 11.08 9 43544 571 29530403
Wheezing 12.95 11.08 18 43535 33222 29497752
Leukopenia 12.95 11.08 40 43513 55163 29475811
Hepatic cancer 12.85 11.08 29 43524 6427 29524547
Heat illness 12.76 11.08 6 43547 181 29530793
Bile duct cancer 12.55 11.08 9 43544 608 29530366
Adenocarcinoma pancreas 12.49 11.08 12 43541 1219 29529755
Carotid artery stenosis 12.36 11.08 23 43530 4446 29526528
Dialysis 12.28 11.08 38 43515 10170 29520804
Retinal haemorrhage 12.24 11.08 23 43530 4481 29526493
Anxiety 12.00 11.08 75 43478 85290 29445684
Fasting 11.96 11.08 3 43550 11 29530963
Therapy non-responder 11.79 11.08 17 43536 30894 29500080
Pancreatic neuroendocrine tumour 11.76 11.08 6 43547 217 29530757
Retinal aneurysm 11.66 11.08 5 43548 121 29530853
Symmetrical drug-related intertriginous and flexural exanthema 11.61 11.08 6 43547 223 29530751
Blood lactic acid increased 11.59 11.08 26 43527 5740 29525234
Gamma-glutamyltransferase increased 11.45 11.08 73 43480 26664 29504310
Suicidal ideation 11.45 11.08 21 43532 34695 29496279
Hypersensitivity 11.26 11.08 40 43513 52863 29478111
Coagulation factor increased 11.21 11.08 4 43549 58 29530916
Blood ketone body increased 11.21 11.08 7 43546 375 29530599

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypoglycaemia 3200.19 10.43 1676 68560 88216 64340280
Lactic acidosis 635.55 10.43 530 69706 60880 64367616
Blood glucose increased 623.79 10.43 645 69591 97428 64331068
Hypoglycaemic coma 617.88 10.43 216 70020 4058 64424438
Diabetes mellitus inadequate control 448.35 10.43 283 69953 21038 64407458
Glycosylated haemoglobin increased 362.99 10.43 223 70013 15796 64412700
Acute kidney injury 216.27 10.43 1014 69222 448226 63980270
Hyperglycaemia 213.23 10.43 296 69940 60672 64367824
Blood glucose decreased 205.33 10.43 183 70053 22940 64405556
Hypoglycaemic encephalopathy 201.73 10.43 58 70178 554 64427942
Cerebral infarction 199.99 10.43 235 70001 40809 64387687
Myocardial infarction 177.41 10.43 487 69749 165334 64263162
Hyperkalaemia 166.41 10.43 351 69885 100778 64327718
Bladder cancer 161.96 10.43 117 70119 10857 64417639
Off label use 152.76 10.43 286 69950 632520 63795976
Pancreatitis 136.35 10.43 238 69998 59369 64369127
Pancreatitis acute 134.99 10.43 198 70038 42657 64385839
Drug ineffective 133.98 10.43 469 69767 839778 63588718
Cardiac failure congestive 132.20 10.43 376 69860 130204 64298292
Diabetic ketoacidosis 124.47 10.43 158 70078 29687 64398809
Coronary artery disease 118.83 10.43 226 70010 60207 64368289
Pancreatic carcinoma 114.40 10.43 93 70143 10280 64418216
Joint swelling 109.06 10.43 49 70187 215333 64213163
Diabetic metabolic decompensation 99.84 10.43 52 70184 2676 64425820
Altered state of consciousness 96.81 10.43 159 70077 37743 64390753
Infusion related reaction 95.65 10.43 30 70206 164437 64264059
Diabetes mellitus 88.33 10.43 212 70024 66262 64362234
Synovitis 84.64 10.43 6 70230 99084 64329412
Drug intolerance 84.41 10.43 50 70186 187942 64240554
Hepatic function abnormal 83.20 10.43 203 70033 64110 64364386
Renal failure 81.86 10.43 403 69833 181285 64247211
Decreased appetite 79.25 10.43 551 69685 280738 64147758
Maternal exposure during pregnancy 78.56 10.43 7 70229 95877 64332619
Drug abuse 77.23 10.43 24 70212 132350 64296146
Product use in unapproved indication 71.16 10.43 53 70183 176565 64251931
Lower respiratory tract infection 69.77 10.43 10 70226 94604 64333892
Interstitial lung disease 63.36 10.43 242 69994 97490 64331006
Hypersensitivity 59.41 10.43 76 70160 196376 64232120
Blood glucose abnormal 59.02 10.43 60 70176 8853 64419643
Contraindicated product administered 58.64 10.43 22 70214 107807 64320689
Exposure during pregnancy 57.76 10.43 8 70228 77667 64350829
Systemic lupus erythematosus 57.70 10.43 8 70228 77604 64350892
Arthralgia 56.85 10.43 268 69968 441992 63986504
Rheumatoid arthritis 56.82 10.43 57 70179 164237 64264259
Metabolic acidosis 56.52 10.43 188 70048 70770 64357726
Cardiac failure 56.32 10.43 289 69947 132084 64296412
Pain 55.58 10.43 364 69872 553147 63875349
Renal impairment 55.53 10.43 292 69944 134725 64293771
Euglycaemic diabetic ketoacidosis 54.44 10.43 46 70190 5364 64423132
Pemphigoid 52.95 10.43 68 70168 12918 64415578
Bladder transitional cell carcinoma 49.13 10.43 31 70205 2299 64426197
Gastric cancer 47.23 10.43 46 70190 6447 64422049
Blood lactic acid 46.86 10.43 18 70218 445 64428051
Blood glucose fluctuation 46.74 10.43 44 70192 5911 64422585
Diabetic retinopathy 45.88 10.43 32 70204 2807 64425689
Fatigue 44.68 10.43 562 69674 748168 63680328
Acute myocardial infarction 44.65 10.43 172 70064 69546 64358950
Hepatocellular carcinoma 44.07 10.43 50 70186 8353 64420143
Therapeutic product effect decreased 43.44 10.43 37 70199 115314 64313182
Pemphigus 43.41 10.43 7 70229 60694 64367802
Neuroglycopenia 42.31 10.43 11 70225 69 64428427
Diabetic neuropathy 41.34 10.43 40 70196 5561 64422935
Loss of consciousness 41.33 10.43 290 69946 148075 64280421
Neutropenia 41.19 10.43 129 70107 239495 64189001
Hypothermia 39.93 10.43 75 70161 19781 64408715
Dehydration 39.55 10.43 385 69851 216378 64212118
Urine ketone body present 39.34 10.43 31 70205 3276 64425220
Glossodynia 39.05 10.43 11 70225 64685 64363811
Alopecia 38.80 10.43 76 70160 165614 64262882
Product use issue 37.81 10.43 67 70169 151648 64276848
Drug hypersensitivity 37.46 10.43 133 70103 237682 64190814
Ketosis 37.28 10.43 19 70217 934 64427562
Blood creatinine increased 36.99 10.43 264 69972 135518 64292978
Sinusitis 36.77 10.43 64 70172 145864 64282632
Cold sweat 36.69 10.43 65 70171 16390 64412106
Angina pectoris 36.39 10.43 120 70116 44961 64383535
Headache 36.35 10.43 385 69851 529082 63899414
Completed suicide 35.68 10.43 125 70111 224289 64204207
Treatment failure 35.49 10.43 45 70191 116771 64311725
Febrile neutropenia 35.16 10.43 97 70139 187560 64240936
MELAS syndrome 34.91 10.43 11 70225 147 64428349
Musculoskeletal stiffness 34.86 10.43 50 70186 123156 64305340
Rhabdomyolysis 34.07 10.43 193 70043 91533 64336963
Liver disorder 33.65 10.43 131 70105 53220 64375276
Cholelithiasis 33.10 10.43 117 70119 45389 64383107
Thrombotic cerebral infarction 32.50 10.43 14 70222 468 64428028
Postprandial hypoglycaemia 32.29 10.43 9 70227 76 64428420
Nasopharyngitis 31.98 10.43 108 70128 195965 64232531
Diabetic nephropathy 31.83 10.43 25 70211 2629 64425867
Hypoglycaemic unconsciousness 31.66 10.43 18 70218 1103 64427393
Arthropathy 31.44 10.43 52 70184 120915 64307581
Swelling 31.38 10.43 81 70155 160137 64268359
Toxicity to various agents 30.65 10.43 251 69985 363262 64065234
Colon cancer 30.59 10.43 52 70184 12687 64415809
Oedema peripheral 30.17 10.43 356 69880 209961 64218535
Pancreatic carcinoma metastatic 29.82 10.43 27 70209 3451 64425045
Intentional product use issue 29.74 10.43 36 70200 95328 64333168
Ketoacidosis 29.66 10.43 37 70199 6826 64421670
Ill-defined disorder 29.51 10.43 6 70230 44046 64384450
Shock 29.27 10.43 100 70136 38140 64390356
Hyperinsulinaemia 28.79 10.43 10 70226 184 64428312
Blood creatine phosphokinase increased 28.57 10.43 133 70103 58425 64370071
Lipase increased 28.46 10.43 54 70182 14348 64414148
Dyslalia 28.31 10.43 16 70220 969 64427527
Albumin urine present 28.27 10.43 14 70222 647 64427849
Cerebrovascular accident 27.90 10.43 250 69986 137333 64291163
Myocardial ischaemia 27.54 10.43 71 70165 23180 64405316
Blood urea increased 27.51 10.43 108 70128 44045 64384451
Infection 27.39 10.43 106 70130 184774 64243722
Hepatic cancer 27.27 10.43 37 70199 7411 64421085
Ischaemic cardiomyopathy 26.62 10.43 35 70201 6803 64421693
Helicobacter infection 26.17 10.43 5 70231 38357 64390139
Retinal haemorrhage 25.96 10.43 36 70200 7362 64421134
Insulin C-peptide increased 25.31 10.43 8 70228 108 64428388
Drug resistance 25.20 10.43 4 70232 35098 64393398
Wound 24.78 10.43 28 70208 76449 64352047
Weight decreased 24.78 10.43 443 69793 285296 64143200
Duodenal ulcer perforation 24.74 10.43 4 70232 34621 64393875
Diarrhoea 24.72 10.43 991 69245 721713 63706783
Blood pressure fluctuation 24.40 10.43 13 70223 51858 64376638
Hypoparathyroidism 24.40 10.43 14 70222 873 64427623
Transient ischaemic attack 24.30 10.43 104 70132 44078 64384418
Latent autoimmune diabetes in adults 23.71 10.43 7 70229 74 64428422
Hyperuricaemia 23.69 10.43 41 70195 10150 64418346
Arteriosclerosis 23.67 10.43 53 70183 15824 64412672
Anuria 23.60 10.43 59 70177 18905 64409591
Diabetic complication 23.44 10.43 15 70221 1140 64427356
Peripheral swelling 23.28 10.43 133 70103 209020 64219476
Coronary artery stenosis 23.25 10.43 43 70193 11205 64417291
Mobility decreased 23.15 10.43 36 70200 85804 64342692
Cardiac disorder 23.12 10.43 121 70115 55695 64372801
Shock hypoglycaemic 22.76 10.43 9 70227 241 64428255
Azotaemia 22.66 10.43 34 70202 7468 64421028
Mucosal inflammation 22.45 10.43 21 70215 62563 64365933
Hyperglycaemic hyperosmolar nonketotic syndrome 22.38 10.43 17 70219 1702 64426794
Prerenal failure 21.90 10.43 22 70214 3200 64425296
Fall 21.77 10.43 601 69635 416225 64012271
Haemorrhagic cerebral infarction 21.68 10.43 15 70221 1299 64427197
Irritable bowel syndrome 21.38 10.43 7 70229 37362 64391134
Migraine 21.36 10.43 22 70214 62655 64365841
Pericarditis 21.24 10.43 22 70214 62494 64366002
Lacunar infarction 21.05 10.43 28 70208 5504 64422992
Macular oedema 20.65 10.43 26 70210 4841 64423655
Glycosylated haemoglobin decreased 20.44 10.43 11 70225 605 64427891
Injection site nodule 20.04 10.43 21 70215 3209 64425287
Blood insulin increased 19.81 10.43 9 70227 342 64428154
Sopor 19.66 10.43 74 70162 29587 64398909
Pyelonephritis acute 19.56 10.43 26 70210 5108 64423388
Blindness transient 19.07 10.43 23 70213 4099 64424397
Ectopic ACTH syndrome 19.07 10.43 7 70229 152 64428344
Blood potassium increased 19.07 10.43 67 70169 25913 64402583
Discomfort 19.00 10.43 37 70199 80841 64347655
Amylase increased 18.75 10.43 36 70200 9649 64418847
Hyperhidrosis 18.58 10.43 213 70023 124707 64303789
Cholangiocarcinoma 17.96 10.43 16 70220 2002 64426494
Biopsy skin abnormal 17.75 10.43 7 70229 186 64428310
Drug level increased 17.67 10.43 79 70157 34117 64394379
Platelet count decreased 17.47 10.43 268 69968 167443 64261053
Blood ketone body increased 17.45 10.43 10 70226 622 64427874
Cholecystitis 17.42 10.43 54 70182 19582 64408914
Anti-insulin antibody increased 17.04 10.43 6 70230 115 64428381
Muscle injury 16.90 10.43 4 70232 26433 64402063
Serotonin syndrome 16.84 10.43 11 70225 39271 64389225
Ketonuria 16.69 10.43 12 70224 1105 64427391
Hyperlipidaemia 16.64 10.43 59 70177 22917 64405579
Anxiety 16.56 10.43 141 70095 202508 64225988
Gastroenteritis 16.39 10.43 70 70166 29641 64398855
Psoriatic arthropathy 16.15 10.43 14 70222 43267 64385229
Nephrogenic anaemia 16.12 10.43 19 70217 3306 64425190
Sudden hearing loss 16.11 10.43 14 70222 1696 64426800
Angina unstable 16.07 10.43 45 70191 15422 64413074
Therapeutic response decreased 15.95 10.43 20 70216 52168 64376328
Dermatitis exfoliative 15.93 10.43 35 70201 10317 64418179
Blood triglycerides increased 15.92 10.43 51 70185 18815 64409681
Contusion 15.83 10.43 67 70169 113898 64314598
Blood lactic acid increased 15.82 10.43 35 70201 10366 64418130
Abortion spontaneous 15.69 10.43 4 70232 25139 64403357
Bile duct stone 15.66 10.43 23 70213 4955 64423541
C-reactive protein abnormal 15.66 10.43 6 70230 29041 64399455
Gastrointestinal disorder 15.60 10.43 48 70188 89661 64338835
Poverty of speech 15.56 10.43 9 70227 570 64427926
Gingival hypertrophy 15.53 10.43 17 70219 2730 64425766
Gamma-glutamyltransferase increased 15.40 10.43 98 70138 48412 64380084
Brain stem infarction 15.33 10.43 14 70222 1809 64426687
Blood lactate dehydrogenase increased 15.31 10.43 74 70162 33004 64395492
Hyperventilation 15.22 10.43 27 70209 6813 64421683
Acute coronary syndrome 15.22 10.43 51 70185 19259 64409237
Arthritis 15.18 10.43 44 70192 83770 64344726
Hemiplegia 15.13 10.43 39 70197 12729 64415767
Diabetic gangrene 15.13 10.43 6 70230 162 64428334
Adenocarcinoma pancreas 15.01 10.43 14 70222 1859 64426637
Renal disorder 14.87 10.43 77 70159 35288 64393208
Wheezing 14.82 10.43 42 70194 80537 64347959
Peripheral arterial occlusive disease 14.81 10.43 27 70209 6960 64421536
Ureteric cancer recurrent 14.77 10.43 4 70232 30 64428466
Therapy non-responder 14.75 10.43 31 70205 65868 64362628
Loss of personal independence in daily activities 14.67 10.43 36 70200 72418 64356078
Insulin resistance 14.59 10.43 11 70225 1089 64427407
Leukopenia 14.38 10.43 59 70177 101183 64327313
Reperfusion injury 14.38 10.43 6 70230 185 64428311
Atrial fibrillation 14.37 10.43 264 69972 170825 64257671
Polyuria 14.35 10.43 38 70198 12605 64415891
Urine ketone body 14.35 10.43 6 70230 186 64428310
Jaundice 14.18 10.43 96 70140 48416 64380080
Hip arthroplasty 14.11 10.43 3 70233 21348 64407148
Product commingling 14.01 10.43 5 70231 100 64428396
Anaphylactic reaction 13.99 10.43 34 70202 68630 64359866
Impaired healing 13.92 10.43 28 70208 60445 64368051
Joint stiffness 13.75 10.43 8 70228 30396 64398100
Sedation 13.63 10.43 15 70221 41447 64387049
Cytokine release syndrome 13.62 10.43 3 70233 20826 64407670
Depressed level of consciousness 13.55 10.43 142 70094 81294 64347202
Injection site swelling 13.55 10.43 15 70221 41338 64387158
Brain stem haemorrhage 13.22 10.43 12 70224 1539 64426957
Abdominal discomfort 13.10 10.43 131 70105 182191 64246305
Generalised oedema 12.98 10.43 51 70185 20802 64407694
Transitional cell carcinoma 12.86 10.43 14 70222 2235 64426261
Anaemia vitamin B12 deficiency 12.86 10.43 8 70228 579 64427917
Cough 12.74 10.43 242 69994 301906 64126590
Cytomegalovirus infection 12.74 10.43 13 70223 37186 64391310
Vitamin B12 deficiency 12.70 10.43 22 70214 5450 64423046
Dry eye 12.61 10.43 8 70228 29011 64399485
Cerebral haemorrhage 12.57 10.43 97 70139 50993 64377503
Status epilepticus 12.50 10.43 4 70232 21659 64406837
Glycosylated haemoglobin abnormal 12.43 10.43 5 70231 140 64428356
Sudden death 12.39 10.43 49 70187 20047 64408449
Lymphocyte stimulation test positive 12.37 10.43 10 70226 1096 64427400
Rash 12.31 10.43 393 69843 458156 63970340
Coagulation test abnormal 12.27 10.43 10 70226 1109 64427387
Atrioventricular block complete 12.19 10.43 39 70197 14379 64414117
Diabetic coma 12.18 10.43 10 70226 1121 64427375
Thyroid adenoma 12.08 10.43 5 70231 151 64428345
Hepatic steatosis 12.01 10.43 66 70170 30941 64397555
Ventricular tachycardia 12.00 10.43 71 70165 34194 64394302
Oliguria 11.94 10.43 39 70197 14537 64413959
Renal abscess 11.88 10.43 9 70227 898 64427598
Cardiac failure acute 11.86 10.43 42 70194 16302 64412194
Embolic stroke 11.85 10.43 24 70212 6687 64421809
Syncope 11.79 10.43 239 69997 157396 64271100
Hyporesponsive to stimuli 11.72 10.43 12 70224 1785 64426711
Peripheral vascular disorder 11.69 10.43 25 70211 7236 64421260
Anti-insulin antibody 11.65 10.43 4 70232 71 64428425
Bladder neoplasm 11.58 10.43 11 70225 1495 64427001
Bradycardia 11.58 10.43 187 70049 118032 64310464
Blood insulin decreased 11.51 10.43 3 70233 19 64428477
Bile duct cancer 11.44 10.43 9 70227 949 64427547
Ischaemic stroke 11.38 10.43 62 70174 28973 64399523
Pancreatic disorder 11.31 10.43 15 70221 2939 64425557
Device related infection 11.31 10.43 10 70226 30616 64397880
Suicidal ideation 11.29 10.43 36 70200 66506 64361990
Carotid artery stenosis 11.27 10.43 26 70210 7915 64420581
Diabetic hyperglycaemic coma 11.20 10.43 4 70232 80 64428416
Progressive multifocal leukoencephalopathy 11.19 10.43 3 70233 18229 64410267
Cholangitis acute 11.18 10.43 10 70226 1258 64427238
Coagulation factor increased 11.11 10.43 4 70232 82 64428414
Dialysis 11.04 10.43 42 70194 16878 64411618
Osteoporosis 11.01 10.43 18 70218 42062 64386434
Mixed anxiety and depressive disorder 10.91 10.43 5 70231 194 64428302
Continuous haemodiafiltration 10.91 10.43 12 70224 1938 64426558
Respiratory depression 10.84 10.43 6 70230 23437 64405059
Cardiovascular disorder 10.84 10.43 40 70196 15841 64412655
Ear pain 10.83 10.43 7 70229 25129 64403367
Glucose urine present 10.83 10.43 11 70225 1621 64426875
Anaemia 10.81 10.43 510 69726 378170 64050326
Vitreous haemorrhage 10.81 10.43 15 70221 3070 64425426
Haemorrhage subcutaneous 10.73 10.43 18 70218 4343 64424153
Condition aggravated 10.52 10.43 317 69919 372109 64056387

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A10BB12 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Sulfonylureas
ATC A10BD04 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Combinations of oral blood glucose lowering drugs
ATC A10BD06 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Combinations of oral blood glucose lowering drugs
FDA CS M0020795 Sulfonylurea Compounds
CHEBI has role CHEBI:35526 antidiabetic
CHEBI has role CHEBI:90415 insulin secretagogues
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D007004 Hypoglycemic Agents
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
FDA EPC N0000175608 Sulfonylurea

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Diabetes mellitus type 2 indication 44054006 DOID:9352
Treatment Refractory Type 2 Diabetes Mellitus indication
Alcoholism contraindication 7200002
Weight gain finding contraindication 8943002
Asthenia contraindication 13791008
Pulmonary edema contraindication 19242006 DOID:11396
Myocardial infarction contraindication 22298006 DOID:5844
Macular retinal edema contraindication 37231002 DOID:4449
Infectious disease contraindication 40733004
Body fluid retention contraindication 43498006
Chronic heart failure contraindication 48447003
Hepatic porphyria contraindication 55056006 DOID:3133
Hemolytic anemia contraindication 61261009 DOID:583
Glucose-6-phosphate dehydrogenase deficiency anemia contraindication 62403005
Osteoporosis contraindication 64859006 DOID:11476
Hypopituitarism contraindication 74728003 DOID:9406
Kidney disease contraindication 90708001 DOID:557
Fracture of bone contraindication 125605004
Autonomic dysreflexia contraindication 129618003
Liver function tests abnormal contraindication 166603001
Angina pectoris contraindication 194828000
Decompensated cardiac failure contraindication 195111005
Cerebrovascular accident contraindication 230690007
Disease of liver contraindication 235856003 DOID:409
Drug-induced hepatitis contraindication 235876009
Hypoglycemic disorder contraindication 237630007
Edema contraindication 267038008
Osteopenia contraindication 312894000
Primary adrenocortical insufficiency contraindication 373662000
Fever contraindication 386661006
Surgical procedure contraindication 387713003
Malignant tumor of urinary bladder contraindication 399326009 DOID:11054
Breastfeeding (mother) contraindication 413712001
Disorder of coronary artery contraindication 414024009
Myocardial ischemia contraindication 414795007 DOID:3393
Traumatic injury contraindication 417746004
Fever greater than 100.4 Fahrenheit contraindication 426000000




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.31 acidic
pKa2 13.98 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sulfonylurea receptor 1, Kir6.2 Ion channel BLOCKER Ki 9.24 WOMBAT-PK CHEMBL
Aldo-keto reductase family 1 member C3 Enzyme IC50 6.07 CHEMBL
Sulfonylurea receptor 2, Kir6.2 Ion channel BLOCKER Ki 7.98 WOMBAT-PK

External reference:

IDSource
4020945 VUID
N0000148425 NUI
D00593 KEGG_DRUG
4020945 VANDF
C0061323 UMLSCUI
CHEBI:5383 CHEBI
GMR PDB_CHEM_ID
CHEMBL1481 ChEMBL_ID
DB00222 DRUGBANK_ID
C057619 MESH_SUPPLEMENTAL_RECORD_UI
6820 IUPHAR_LIGAND_ID
5718 INN_ID
6KY687524K UNII
3476 PUBCHEM_CID
25789 RXNORM
4782 MMSL
72042 MMSL
d03864 MMSL
005624 NDDF
109079009 SNOMEDCT_US
386966003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
AMARYL HUMAN PRESCRIPTION DRUG LABEL 1 0039-0221 TABLET 1 mg ORAL NDA 26 sections
AMARYL HUMAN PRESCRIPTION DRUG LABEL 1 0039-0222 TABLET 2 mg ORAL NDA 26 sections
AMARYL HUMAN PRESCRIPTION DRUG LABEL 1 0039-0223 TABLET 4 mg ORAL NDA 26 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 0440-6564 TABLET 1 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 0440-6565 TABLET 2 mg ORAL ANDA 26 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 0440-6566 TABLET 4 mg ORAL ANDA 26 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8332 TABLET 1 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8333 TABLET 2 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8334 TABLET 4 mg ORAL ANDA 25 sections
Pioglitazone hydrochloride and glimepiride HUMAN PRESCRIPTION DRUG LABEL 2 0781-5634 TABLET 2 mg ORAL ANDA 28 sections
Pioglitazone hydrochloride and glimepiride HUMAN PRESCRIPTION DRUG LABEL 2 0781-5635 TABLET 4 mg ORAL ANDA 28 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 10544-217 TABLET 2 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 10544-219 TABLET 4 mg ORAL ANDA 25 sections
Glimepiride Human Prescription Drug Label 1 16571-773 TABLET 1 mg ORAL ANDA 25 sections
Glimepiride Human Prescription Drug Label 1 16571-774 TABLET 2 mg ORAL ANDA 25 sections
Glimepiride Human Prescription Drug Label 1 16571-775 TABLET 4 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 16729-001 TABLET 1 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 16729-002 TABLET 2 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 16729-003 TABLET 4 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 21695-746 TABLET 2 mg ORAL ANDA 20 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 21695-747 TABLET 4 mg ORAL ANDA 20 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 21695-993 TABLET 1 mg ORAL ANDA 20 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 33261-831 TABLET 2 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 33261-892 TABLET 4 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 33261-961 TABLET 1 mg ORAL ANDA 26 sections
GLIMEPIRIDE HUMAN PRESCRIPTION DRUG LABEL 1 42549-498 TABLET 4 mg ORAL ANDA 28 sections
GLIMEPIRIDE HUMAN PRESCRIPTION DRUG LABEL 1 42549-499 TABLET 2 mg ORAL ANDA 24 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 42571-100 TABLET 1 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 42571-101 TABLET 2 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 42571-102 TABLET 3 mg ORAL ANDA 25 sections