glafenine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| analgesics, glafenine derivatives (subgroup of fenamic acid group) | 1297 | 3820-67-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An anthranilic acid derivative with analgesic properties used for the relief of all types of pain.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.80 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Hosey CM, Chan R, Benet LZ |
| S (Water solubility) | 0.02 mg/mL | Bocci G, Oprea TI, Benet LZ |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N02BG03 | NERVOUS SYSTEM ANALGESICS OTHER ANALGESICS AND ANTIPYRETICS Other analgesics and antipyretics |
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D018712 | Analgesics, Non-Narcotic |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D018689 | Sensory System Agents |
| CHEBI has role | CHEBI:35222 | inhibitor |
| CHEBI has role | CHEBI:35475 | non-steroidal anti-inflammatory agent |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 13.75 | acidic |
| pKa2 | 6.97 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Bile salt export pump | Transporter | IC50 | 4.65 | CHEMBL | |||||
| Bile salt export pump | Transporter | IC50 | 4.49 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D01351 | KEGG_DRUG |
| C0017592 | UMLSCUI |
| CHEBI:31653 | CHEBI |
| CHEMBL146095 | ChEMBL_ID |
| DB08963 | DRUGBANK_ID |
| D005897 | MESH_DESCRIPTOR_UI |
| 3474 | PUBCHEM_CID |
| 1890 | INN_ID |
| 65513-72-6 | SECONDARY_CAS_RN |
| 46HL4I09AH | UNII |
| 006856 | NDDF |
Pharmaceutical products:
None