gimeracil 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
uracil type antineoplastics	1293	103766-25-2

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

5-chloro-2,4-dihydroxypyridine
gimeracil
gimestat
5-Chloro-4-hydroxy-2-pyridone

a biochemical and pharmacological modulator of 5-FU

Molecular weight: 145.54
Formula: C5H4ClNO2
CLOGP: -0.16
LIPINSKI: 0
HAC: 3
HDO: 2
TPSA: 49.33
ALOGS: -1.01
ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
March 14, 2011	EMA	Nordic Group BV
March 1, 1999	PMDA	Taiho Pharmaceutical Co, Ltd

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Malignant tumor of stomach	indication	363349007	DOID:10534
Hormone receptor pozitive breast cancer	indication	417181009
HER2negative breast cancer	indication	767444009

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.96	acidic
pKa2	11.84	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Dihydropyrimidine dehydrogenase [NADP(+)]	Enzyme	Q12882	DPYD_HUMAN	INHIBITOR	Ki	6.64		SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE

External reference:

ID	Source
D01846	KEGG_DRUG
C0535459	UMLSCUI
CHEBI:31652	CHEBI
CHEMBL1730601	ChEMBL_ID
DB09257	DRUGBANK_ID
54679224	PUBCHEM_CID
7728	INN_ID
C104201	MESH_SUPPLEMENTAL_RECORD_UI
UA8SE1325T	UNII
013264	NDDF
712518000	SNOMEDCT_US

Pharmaceutical products:

None