gestodene 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| steroids, progestogens | 1291 | 60282-87-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
synthetic steroid with progestational activity; RN given refers to (17alpha)-isomer
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.00 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 93 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.46 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 0.80 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.02 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 10 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | G03AA10 | GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE Progestogens and estrogens, fixed combinations |
| ATC | G03AB06 | GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE Progestogens and estrogens, sequential preparations |
| MeSH PA | D003270 | Contraceptive Agents |
| MeSH PA | D003271 | Contraceptive Agents, Female |
| MeSH PA | D000080066 | Contraceptive Agents, Hormonal |
| MeSH PA | D003278 | Contraceptives, Oral, Hormonal |
| MeSH PA | D003280 | Contraceptives, Oral, Synthetic |
| MeSH PA | D006728 | Hormones |
| MeSH PA | D011372 | Progestins |
| MeSH PA | D012102 | Reproductive Control Agents |
| CHEBI has role | CHEBI:50114 | estrogens |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Progesterone receptor | Nuclear hormone receptor | WOMBAT-PK | |||||||
| Cytochrome P450 3A5 | Enzyme | WOMBAT-PK |
External reference:
| ID | Source |
|---|---|
| D04316 | KEGG_DRUG |
| C0061246 | UMLSCUI |
| CHEBI:135323 | CHEBI |
| CHEMBL1213583 | ChEMBL_ID |
| DB06730 | DRUGBANK_ID |
| C033273 | MESH_SUPPLEMENTAL_RECORD_UI |
| 3033968 | PUBCHEM_CID |
| 11246 | IUPHAR_LIGAND_ID |
| 4244 | INN_ID |
| 1664P6E6MI | UNII |
| 25734 | RXNORM |
| 003971 | NDDF |
| 395945000 | SNOMEDCT_US |
| 437760006 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| MYVLAR | HUMAN OTC DRUG LABEL | 2 | 72689-0012 | TABLET | 0.08 mg | ORAL | unapproved drug other | 7 sections |