gamolenic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1276 | 506-26-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An omega-6 fatty acid produced in the body as the delta 6-desaturase metabolite of linoleic acid. It is converted to dihomo-gamma-linolenic acid, a biosynthetic precursor of monoenoic prostaglandins such as PGE1. (From Merck Index, 11th ed)
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.40 | g | O |
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D11AX02 | DERMATOLOGICALS OTHER DERMATOLOGICAL PREPARATIONS OTHER DERMATOLOGICAL PREPARATIONS Other dermatologicals |
| ATC | D11AX52 | DERMATOLOGICALS OTHER DERMATOLOGICAL PREPARATIONS OTHER DERMATOLOGICAL PREPARATIONS Other dermatologicals |
| CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
| CHEBI has role | CHEBI:76924 | plant metabolites |
| CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.6 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| 3-oxo-5-alpha-steroid 4-dehydrogenase 2 | Enzyme | IC50 | 4.85 | CHEMBL | |||||
| Peroxisome proliferator-activated receptor alpha | Nuclear hormone receptor | IC50 | 6.57 | CHEMBL | |||||
| Peroxisome proliferator-activated receptor gamma | Nuclear hormone receptor | IC50 | 5.66 | CHEMBL | |||||
| Peroxisome proliferator-activated receptor delta | Nuclear hormone receptor | IC50 | 6.12 | CHEMBL | |||||
| Free fatty acid receptor 1 | GPCR | EC50 | 5.33 | CHEMBL | |||||
| Tissue factor | Membrane receptor | IC50 | 4.52 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| N0000168580 | NUI |
| D07213 | KEGG_DRUG |
| CHEBI:28661 | CHEBI |
| CHEMBL464982 | ChEMBL_ID |
| 2834 | INN_ID |
| DB13854 | DRUGBANK_ID |
| 78YC2MAX4O | UNII |
| 25605 | RXNORM |
| 003969 | NDDF |
| 13121007 | SNOMEDCT_US |
| 427465009 | SNOMEDCT_US |
| C0061078 | UMLSCUI |
| D017965 | MESH_DESCRIPTOR_UI |
| 5280933 | PUBCHEM_CID |
Pharmaceutical products:
None