gamolenic acid Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1276 506-26-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • gamma-Linolenic Acid
  • gamolenic
  • gamolenic acid
An omega-6 fatty acid produced in the body as the delta 6-desaturase metabolite of linoleic acid. It is converted to dihomo-gamma-linolenic acid, a biosynthetic precursor of monoenoic prostaglandins such as PGE1. (From Merck Index, 11th ed)
  • Molecular weight: 278.44
  • Formula: C18H30O2
  • CLOGP: 6.82
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 1
  • TPSA: 37.30
  • ALOGS: -6.04
  • ROTB: 13

Drug dosage:

DoseUnitRoute
0.40 g O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC D11AX02 DERMATOLOGICALS
OTHER DERMATOLOGICAL PREPARATIONS
OTHER DERMATOLOGICAL PREPARATIONS
Other dermatologicals
ATC D11AX52 DERMATOLOGICALS
OTHER DERMATOLOGICAL PREPARATIONS
OTHER DERMATOLOGICAL PREPARATIONS
Other dermatologicals
CHEBI has role CHEBI:75771 mus musculus metabolite
CHEBI has role CHEBI:76924 plant metabolites
CHEBI has role CHEBI:77746 h. sapiens metabolites

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.6 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Peroxisome proliferator-activated receptor gamma Nuclear hormone receptor IC50 5.66 CHEMBL
Peroxisome proliferator-activated receptor delta Nuclear hormone receptor IC50 6.12 CHEMBL
Peroxisome proliferator-activated receptor alpha Nuclear hormone receptor IC50 6.57 CHEMBL
Tissue factor Membrane receptor IC50 4.52 CHEMBL
3-oxo-5-alpha-steroid 4-dehydrogenase 2 Enzyme IC50 4.85 CHEMBL

External reference:

IDSource
N0000168580 NUI
D07213 KEGG_DRUG
C0061078 UMLSCUI
CHEBI:28661 CHEBI
CHEMBL464982 ChEMBL_ID
DB13854 DRUGBANK_ID
D017965 MESH_DESCRIPTOR_UI
2834 INN_ID
78YC2MAX4O UNII
5280933 PUBCHEM_CID
25605 RXNORM
003969 NDDF
13121007 SNOMEDCT_US
427465009 SNOMEDCT_US

Pharmaceutical products:

None