gabapentin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
gabamimetic agents 1264 60142-96-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • gabapentin
  • gabamox
  • gabapen
  • neurontin
  • gabapentine
The mechanism by which gabapentin exerts its analgesic action is unknown, but in animal models of analgesia, gabapentin prevents allodynia (pain-related behavior in response to a normally innocuous stimulus) and hyperalgesia (exaggerated response to painful stimuli). In particular, gabapentin prevents pain-related responses in several models of neuropathic pain in rats or mice (e.g., spinal nerve ligation models, streptozocin-induced diabetes model, spinal cord injury model, acute herpes zoster infection model). Gabapentin also decreases pain-related responses after peripheral inflammation (carrageenan footpad test, late phase of formalin test). Gabapentin did not alter immediate pain-related behaviors (rat tail flick test, formalin footpad acute phase, acetic acid abdominal constriction test, footpad heat irradiation test). The mechanism by which gabapentin exerts its anticonvulsant action is unknown, but in animal test systems designed to detect anticonvulsant activity, gabapentin prevents seizures as do other marketed anticonvulsants. Gabapentin exhibits antiseizure activity in mice and rats in both the maximal electroshock and pentylenetetrazole seizure models and other preclinical models (e.g., strains with genetic epilepsy, etc.). Gabapentin is structurally related to the neurotransmitter GABA (gamma-aminobutyric acid) but it does not modify GABAA or GABAB radioligand binding, it is not converted metabolically into GABA or a GABA agonist, and it is not an inhibitor of GABA uptake or degradation. Gabapentin was tested in radioligand binding assays at concentrations up to 100 uM and did not exhibit affinity for a number of other common receptor sites, including benzodiazepine, glutamate, N-methyl-D-aspartate (NMDA), quisqualate, kainate, strychnine-insensitive or strychnine-sensitive glycine, alpha 1, alpha 2, or beta adrenergic, adenosine A1 or A2, cholinergic muscarinic or nicotinic, dopamine D1 or D2, histamine H1, serotonin S1 or S2, opiate mu, delta or kappa, cannabinoid 1, voltage-sensitive calcium channel sites labeled with nitrendipine or diltiazem, or at voltage-sensitive sodium channel sites labeled with batrachotoxinin A 20-alpha-benzoate. Furthermore, gabapentin did not alter the cellular uptake of dopamine, noradrenaline, or serotonin. In vitro studies with radiolabeled gabapentin have revealed a gabapentin binding site in areas of rat brain including neocortex and hippocampus. A high-affinity binding protein in animal brain tissue has been identified as an auxiliary subunit of voltage-activated calcium channels.
  • Molecular weight: 171.24
  • Formula: C9H17NO2
  • CLOGP: -0.66
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 63.32
  • ALOGS: -1.60
  • ROTB: 3

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1.80 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 10 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 100 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 116.79 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 60 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.71 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.70 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.97 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5.30 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 30, 1993 FDA PFIZER PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 1707.99 9.78 4328 289448 239497 46152789
Drug ineffective for unapproved indication 1111.83 9.78 881 292895 15532 46376754
Completed suicide 526.61 9.78 2062 291714 143858 46248428
Multiple sclerosis relapse 375.02 9.78 823 292953 41302 46350984
Pemphigus 252.08 9.78 7 293769 45267 46347019
Rheumatoid arthritis 239.76 9.78 746 293030 239469 46152817
Somnolence 225.34 9.78 1721 292055 154800 46237486
Myoclonus 220.01 9.78 354 293422 13998 46378288
Toxicity to various agents 217.51 9.78 2161 291615 209605 46182681
Contraindicated product administered 202.87 9.78 126 293650 79821 46312465
Maternal exposure during pregnancy 198.75 9.78 211 293565 102338 46289948
Neuropathy peripheral 180.82 9.78 1083 292693 89810 46302476
Neuralgia 172.66 9.78 402 293374 20981 46371305
Fall 169.96 9.78 2961 290815 326136 46066150
Synovitis 168.23 9.78 87 293689 60988 46331298
Drug abuse 160.70 9.78 807 292969 62601 46329685
Febrile neutropenia 160.66 9.78 216 293560 94411 46297875
Balance disorder 150.91 9.78 803 292973 63718 46328568
Memory impairment 148.41 9.78 913 292863 76424 46315862
Accidental death 147.26 9.78 109 293667 1726 46390560
Exposure during pregnancy 146.24 9.78 287 293489 107925 46284361
Suicidal ideation 144.58 9.78 720 293056 55662 46336624
Systemic lupus erythematosus 140.37 9.78 122 293654 65058 46327228
Multiple sclerosis 138.45 9.78 406 293370 24385 46367901
Depression 137.62 9.78 1656 292120 168448 46223838
Feeling abnormal 125.18 9.78 1270 292506 123790 46268496
Tremor 121.87 9.78 1187 292589 114452 46277834
Hypoaesthesia 117.47 9.78 1204 292572 117665 46274621
General physical health deterioration 115.67 9.78 359 293417 115410 46276876
Hand deformity 113.31 9.78 38 293738 34536 46357750
Product complaint 112.86 9.78 241 293535 11860 46380426
Rheumatoid factor positive 107.54 9.78 5 293771 20456 46371830
Dizziness 107.02 9.78 2851 290925 337563 46054723
Pyrexia 104.64 9.78 1555 292221 347247 46045039
Glossodynia 100.55 9.78 79 293697 44294 46347992
Device expulsion 98.03 9.78 26 293750 27516 46364770
Anaemia 96.72 9.78 1086 292690 254693 46137593
Pericarditis 92.26 9.78 19 293757 23908 46368378
Muscle spasms 91.10 9.78 1179 292597 121934 46270352
Confusional state 90.45 9.78 1461 292315 158431 46233855
C-reactive protein abnormal 88.26 9.78 14 293762 21256 46371030
Interstitial lung disease 86.71 9.78 128 293648 53821 46338465
Drug withdrawal syndrome 85.89 9.78 371 293405 27013 46365273
Gait disturbance 85.04 9.78 1335 292441 143928 46248358
Hallucination 84.91 9.78 572 293204 49379 46342907
Vision blurred 84.82 9.78 820 292956 78888 46313398
Thrombocytopenia 84.71 9.78 459 293317 126122 46266164
Infusion related reaction 83.63 9.78 340 293436 100868 46291418
C-reactive protein increased 82.97 9.78 151 293625 58439 46333847
Withdrawal syndrome 82.81 9.78 277 293499 17857 46374429
Mental status changes 82.28 9.78 464 293312 37624 46354662
Respiratory arrest 81.88 9.78 425 293351 33391 46358895
Product dose omission issue 79.56 9.78 1496 292280 167024 46225262
Sedation 79.38 9.78 320 293456 22590 46369696
Joint swelling 77.89 9.78 669 293107 165404 46226882
Pain in extremity 76.77 9.78 2151 291625 256529 46135757
Hepatic function abnormal 72.20 9.78 66 293710 34355 46357931
Treatment failure 69.42 9.78 325 293451 92762 46299524
Cytomegalovirus infection 68.74 9.78 15 293761 18129 46374157
Cardiac failure 68.31 9.78 265 293511 79683 46312603
Paraesthesia 65.22 9.78 1070 292706 116367 46275919
Migraine 64.75 9.78 700 293076 69326 46322960
Multiple organ dysfunction syndrome 64.06 9.78 144 293632 51566 46340720
Pancytopenia 64.00 9.78 296 293480 84762 46307524
Trigeminal neuralgia 62.03 9.78 85 293691 2904 46389382
Neutropenia 61.41 9.78 590 293186 142614 46249672
Amnesia 58.78 9.78 456 293320 41175 46351111
Sopor 58.67 9.78 264 293512 19564 46372722
Coordination abnormal 57.98 9.78 176 293600 10773 46381513
Seizure 57.55 9.78 1091 292685 121963 46270323
Premature baby 57.47 9.78 21 293755 18091 46374195
Anxiety 57.30 9.78 1525 292251 180432 46211854
Foetal exposure during pregnancy 56.52 9.78 66 293710 30681 46361605
Pleural effusion 56.47 9.78 299 293477 82653 46309633
Unresponsive to stimuli 56.21 9.78 371 293405 31803 46360483
Drug dependence 55.93 9.78 261 293515 19640 46372646
Product use in unapproved indication 55.22 9.78 836 292940 89437 46302849
Dyskinesia 55.14 9.78 341 293435 28584 46363702
Red blood cell sedimentation rate abnormal 54.39 9.78 10 293766 13639 46378647
Atrial fibrillation 54.20 9.78 405 293371 103185 46289101
Burning sensation 53.86 9.78 470 293306 43941 46348345
Mucosal inflammation 53.81 9.78 102 293674 38874 46353412
Hypokalaemia 52.56 9.78 331 293445 87693 46304593
Leukopenia 52.50 9.78 236 293540 68107 46324179
Fibromyalgia 52.37 9.78 401 293375 36062 46356224
Hepatic enzyme increased 52.28 9.78 301 293475 81486 46310800
Muscular weakness 51.41 9.78 838 292938 91006 46301280
Malignant neoplasm progression 51.20 9.78 222 293554 64704 46327582
Bone marrow failure 51.06 9.78 67 293709 29602 46362684
Insomnia 49.85 9.78 1375 292401 163549 46228737
Hypersomnia 49.82 9.78 211 293565 15228 46377058
Lethargy 48.92 9.78 515 293261 50656 46341630
Hyponatraemia 48.46 9.78 406 293370 100926 46291360
Blood lactate dehydrogenase increased 48.36 9.78 35 293741 20465 46371821
Erythema 48.30 9.78 621 293155 142199 46250087
Mental disorder 46.99 9.78 271 293505 22154 46370132
Drug reaction with eosinophilia and systemic symptoms 46.60 9.78 71 293705 29477 46362809
Therapeutic response decreased 46.54 9.78 129 293647 43016 46349270
Feeling drunk 45.35 9.78 85 293691 3802 46388484
Arthropathy 45.33 9.78 329 293447 84371 46307915
Abortion spontaneous 44.52 9.78 134 293642 43512 46348774
Speech disorder 44.51 9.78 384 293392 35783 46356503
Sleep apnoea syndrome 44.39 9.78 265 293511 21936 46370350
Respiratory depression 43.40 9.78 166 293610 11434 46380852
Osteonecrosis of jaw 43.26 9.78 95 293681 34307 46357979
Drug resistance 43.17 9.78 28 293748 17340 46374946
Septic shock 42.63 9.78 203 293573 57690 46334596
Pleural thickening 42.52 9.78 66 293710 2529 46389757
Presbyacusis 42.42 9.78 69 293707 2753 46389533
Live birth 42.41 9.78 7 293769 10323 46381963
Myocardial stunning 42.01 9.78 21 293755 154 46392132
Muscle twitching 41.66 9.78 193 293583 14479 46377807
Hepatotoxicity 41.50 9.78 58 293718 24951 46367335
Inadequate analgesia 41.03 9.78 68 293708 2756 46389530
Premature delivery 40.97 9.78 47 293729 22022 46370264
Cardio-respiratory arrest 40.78 9.78 565 293211 59304 46332982
Restless legs syndrome 40.36 9.78 202 293574 15641 46376645
Pleural fibrosis 40.34 9.78 77 293699 3492 46388794
Intentional product misuse 40.31 9.78 464 293312 46664 46345622
Crying 40.14 9.78 249 293527 20892 46371394
Anaphylactic shock 40.05 9.78 41 293735 20233 46372053
Duodenal ulcer perforation 39.13 9.78 4 293772 8498 46383788
Cognitive disorder 38.50 9.78 378 293398 36505 46355781
Full blood count decreased 38.12 9.78 255 293521 21956 46370330
Therapeutic response unexpected 37.61 9.78 196 293580 15420 46376866
Blood magnesium increased 37.59 9.78 68 293708 2959 46389327
Euphoric mood 37.46 9.78 83 293693 4189 46388097
Pneumocystis jirovecii pneumonia 37.33 9.78 25 293751 15223 46377063
Head injury 36.54 9.78 273 293503 24363 46367923
Bradycardia 36.21 9.78 256 293520 66042 46326244
Premature labour 36.02 9.78 13 293763 11286 46381000
Hepatocellular injury 35.92 9.78 83 293693 29439 46362847
Impaired driving ability 35.84 9.78 81 293695 4143 46388143
Abdominal discomfort 34.54 9.78 707 293069 150458 46241828
Peritonitis 34.41 9.78 48 293728 20666 46371620
Influenza like illness 34.36 9.78 531 293245 57039 46335247
Ascites 34.04 9.78 117 293659 36467 46355819
Eosinophilic colitis 34.00 9.78 16 293760 101 46392185
Melaena 33.85 9.78 78 293698 27694 46364592
Alopecia 33.54 9.78 772 293004 161642 46230644
Bone erosion 33.44 9.78 9 293767 9434 46382852
Diplopia 33.43 9.78 223 293553 19182 46373104
Dry mouth 33.31 9.78 508 293268 54418 46337868
Hepatic failure 33.08 9.78 104 293672 33312 46358974
Off label use 32.93 9.78 2006 291770 377835 46014451
Pain 32.91 9.78 3454 290322 473494 45918792
Hypermobility syndrome 32.74 9.78 30 293746 649 46391637
Rash maculo-papular 32.61 9.78 80 293696 27794 46364492
Stiff person syndrome 32.46 9.78 18 293758 167 46392119
Cough 32.20 9.78 1155 292621 229094 46163192
Febrile bone marrow aplasia 32.18 9.78 3 293773 6859 46385427
Hyperaesthesia 31.53 9.78 115 293661 7741 46384545
Jaundice 31.29 9.78 86 293690 28759 46363527
Ataxia 30.94 9.78 171 293605 13759 46378527
Neck pain 30.70 9.78 504 293272 54802 46337484
Epigastric discomfort 30.69 9.78 92 293684 5592 46386694
Mood altered 30.46 9.78 162 293614 12845 46379441
Helicobacter infection 30.45 9.78 18 293758 11718 46380568
Diabetic neuropathy 30.32 9.78 71 293705 3718 46388568
Pregnancy 30.12 9.78 80 293696 27057 46365229
Hallucination, visual 29.96 9.78 204 293572 17669 46374617
Accidental poisoning 29.70 9.78 27 293749 578 46391708
Nerve injury 29.43 9.78 111 293665 7594 46384692
Deafness neurosensory 29.42 9.78 78 293698 4416 46387870
Nervousness 29.32 9.78 291 293485 28184 46364102
Thrombotic microangiopathy 29.25 9.78 8 293768 8298 46383988
Epistaxis 29.23 9.78 261 293515 64044 46328242
Urinary incontinence 29.10 9.78 291 293485 28239 46364047
Somatic symptom disorder 29.08 9.78 47 293729 1865 46390421
Rash 28.61 9.78 1896 291880 354616 46037670
Gastrointestinal haemorrhage 28.58 9.78 330 293446 77043 46315243
Intervertebral disc protrusion 28.52 9.78 223 293553 20182 46372104
Back pain 27.96 9.78 1602 292174 208437 46183849
Rheumatoid nodule 27.71 9.78 11 293765 9009 46383277
Toxic epidermal necrolysis 27.62 9.78 62 293714 22216 46370070
Spinal operation 27.43 9.78 87 293689 5453 46386833
Congenital thrombocytopenia 27.40 9.78 11 293765 44 46392242
Anger 27.34 9.78 147 293629 11705 46380581
Gestational diabetes 27.28 9.78 6 293770 7213 46385073
Back disorder 27.26 9.78 122 293654 9019 46383267
Gait inability 26.79 9.78 339 293437 34864 46357422
Fatigue 26.57 9.78 4287 289489 604410 45787876
Cyst 26.52 9.78 148 293628 11952 46380334
Myelodysplastic syndrome 26.50 9.78 36 293740 15675 46376611
Agranulocytosis 26.49 9.78 63 293713 22122 46370164
Acute respiratory distress syndrome 26.37 9.78 62 293714 21860 46370426
Limb discomfort 26.05 9.78 238 293538 22538 46369748
Concussion 26.02 9.78 100 293676 6903 46385383
Somatic delusion 25.58 9.78 25 293751 588 46391698
Hypersensitivity 25.56 9.78 735 293041 149586 46242700
Human epidermal growth factor receptor decreased 25.34 9.78 8 293768 12 46392274
Incoherent 25.28 9.78 74 293702 4438 46387848
Tachycardia 25.17 9.78 458 293318 99164 46293122
Complex regional pain syndrome 25.13 9.78 46 293730 2020 46390266
Drug-induced liver injury 25.07 9.78 79 293697 25289 46366997
Lower respiratory tract infection 24.86 9.78 224 293552 54865 46337421
Paranoia 24.83 9.78 132 293644 10465 46381821
Cerebral infarction 24.36 9.78 71 293705 23295 46368991
Haemophagocytic lymphohistiocytosis 24.31 9.78 11 293765 8331 46383955
Asterixis 24.04 9.78 34 293742 1197 46391089
Drug screen positive 23.93 9.78 66 293710 3825 46388461
Liver injury 23.77 9.78 40 293736 15961 46376325
Focal dyscognitive seizures 23.74 9.78 54 293722 2774 46389512
Haemoglobin decreased 23.60 9.78 624 293152 128325 46263961
Alanine aminotransferase increased 23.50 9.78 403 293373 88048 46304238
Psychotic disorder due to a general medical condition 23.36 9.78 15 293761 186 46392100
Intervertebral disc degeneration 23.26 9.78 153 293623 13099 46379187
Transplant rejection 23.14 9.78 16 293760 9580 46382706
Transaminases increased 23.07 9.78 93 293683 27668 46364618
Ankle fracture 23.06 9.78 172 293604 15339 46376947
Therapeutic product effect decreased 23.04 9.78 373 293403 82228 46310058
Poisoning 23.02 9.78 159 293617 13835 46378451
Cerebral haemorrhage 22.98 9.78 96 293680 28275 46364011
Dyspnoea 22.82 9.78 2869 290907 512679 45879607
Blood bilirubin increased 22.82 9.78 124 293652 34060 46358226
Urinary tract infection 22.75 9.78 1644 292132 218622 46173664
Central nervous system lesion 22.69 9.78 120 293656 9495 46382791
Mental impairment 22.59 9.78 145 293631 12311 46379975
Pre-eclampsia 22.58 9.78 11 293765 7983 46384303
Visual impairment 22.42 9.78 564 293212 66125 46326161
Dysarthria 22.42 9.78 346 293430 37152 46355134
Anorgasmia 22.40 9.78 23 293753 575 46391711
Sacroiliitis 22.34 9.78 45 293731 2124 46390162
Drug titration error 22.27 9.78 23 293753 579 46391707
Neutropenic sepsis 22.07 9.78 27 293749 12297 46379989
Hyperreflexia 22.02 9.78 78 293698 5176 46387110
Eosinophilia 21.82 9.78 56 293720 19161 46373125
Limb injury 21.74 9.78 200 293576 18974 46373312
Bone cyst 21.66 9.78 43 293733 2008 46390278
Acute kidney injury 21.57 9.78 1239 292537 234616 46157670
Nightmare 21.35 9.78 178 293598 16420 46375866
Acute myeloid leukaemia 21.16 9.78 42 293734 15736 46376550
Device difficult to use 21.16 9.78 12 293764 7992 46384294
Overdose 21.11 9.78 813 292963 101166 46291120
Lactic acidosis 21.02 9.78 126 293650 33783 46358503
Haemorrhage 20.66 9.78 233 293543 54636 46337650
Accidental exposure to product 20.59 9.78 66 293710 21015 46371271
Dysstasia 20.39 9.78 185 293591 17483 46374803
Disseminated intravascular coagulation 20.36 9.78 57 293719 18948 46373338
Substance abuse 20.23 9.78 65 293711 4102 46388184
Abdominal pain 20.21 9.78 1213 292563 228818 46163468
Drug diversion 20.20 9.78 26 293750 835 46391451
Vertigo 20.19 9.78 449 293327 51599 46340687
Foetal growth restriction 20.19 9.78 8 293768 6559 46385727
Thinking abnormal 20.17 9.78 118 293658 9696 46382590
Red blood cell sedimentation rate increased 20.10 9.78 75 293701 22814 46369472
Tuberculosis 20.00 9.78 21 293755 10244 46382042
Abortion induced 19.98 9.78 21 293755 10239 46382047
Cholestasis 19.97 9.78 94 293682 26799 46365487
Device use error 19.66 9.78 4 293772 5077 46387209
Pre-existing condition improved 19.53 9.78 88 293688 6524 46385762
Haematoma 19.45 9.78 119 293657 31753 46360533
Device dislocation 19.43 9.78 71 293705 21731 46370555
Bronchiectasis 19.37 9.78 18 293758 9298 46382988
Torsade de pointes 19.36 9.78 29 293747 12125 46380161
Cardiogenic shock 19.18 9.78 47 293729 16337 46375949
Therapy non-responder 19.15 9.78 166 293610 40986 46351300
Caesarean section 19.15 9.78 48 293728 16555 46375731
Gamma-glutamyltransferase increased 19.12 9.78 119 293657 31621 46360665
Autonomic nervous system imbalance 18.91 9.78 45 293731 2381 46389905
Unintentional medical device removal 18.88 9.78 3 293773 4550 46387736
Posterior reversible encephalopathy syndrome 18.88 9.78 42 293734 15099 46377187
Irritability 18.83 9.78 271 293505 28675 46363611
Hepatitis 18.78 9.78 122 293654 32093 46360193
Serotonin syndrome 18.75 9.78 234 293542 23986 46368300
Ventricular fibrillation 18.73 9.78 27 293749 11469 46380817
Dysphemia 18.67 9.78 44 293732 2314 46389972
Joint injury 18.67 9.78 194 293582 19015 46373271
Metastases to liver 18.65 9.78 62 293714 19523 46372763
Pulmonary aplasia 18.63 9.78 6 293770 10 46392276
Hypotension 18.44 9.78 1238 292538 231351 46160935
Peroneal nerve palsy 18.44 9.78 63 293713 4105 46388181
Allodynia 18.40 9.78 20 293756 535 46391751
Colitis ulcerative 18.40 9.78 54 293722 17678 46374608
Drug effective for unapproved indication 18.34 9.78 34 293742 1508 46390778
Brain injury 18.28 9.78 82 293694 6068 46386218
Post herpetic neuralgia 18.23 9.78 39 293737 1921 46390365
Acute hepatic failure 18.22 9.78 41 293735 14680 46377606
Wrong patient received product 17.84 9.78 36 293740 1701 46390585
Neutrophil count decreased 17.72 9.78 181 293595 43245 46349041
Vomiting 17.59 9.78 2540 291236 450254 45942032
Shock haemorrhagic 17.54 9.78 17 293759 8607 46383679
Pituitary tumour benign 17.46 9.78 35 293741 1646 46390640
Hyperhidrosis 17.32 9.78 707 293069 88601 46303685
Face oedema 17.32 9.78 62 293714 19091 46373195
Myoclonic epilepsy 17.30 9.78 25 293751 898 46391388
Body height decreased 17.28 9.78 112 293664 9540 46382746
Graft versus host disease 17.24 9.78 10 293766 6578 46385708
Secondary progressive multiple sclerosis 17.22 9.78 29 293747 1191 46391095
Progressive multiple sclerosis 17.16 9.78 23 293753 769 46391517
Genital haemorrhage 17.13 9.78 10 293766 6556 46385730
Nerve compression 17.09 9.78 87 293689 6781 46385505
Myelosuppression 17.09 9.78 14 293762 7689 46384597
Circulatory collapse 17.00 9.78 74 293702 21550 46370736
Muscle tightness 16.90 9.78 117 293659 10188 46382098
Liver function test abnormal 16.88 9.78 199 293577 46288 46345998
Discomfort 16.86 9.78 200 293576 46470 46345816
Bone density decreased 16.80 9.78 22 293754 9730 46382556
Colitis 16.79 9.78 152 293624 37195 46355091
Prescription drug used without a prescription 16.78 9.78 31 293745 1371 46390915
Stillbirth 16.78 9.78 10 293766 6481 46385805
Surgery 16.60 9.78 264 293512 28521 46363765
Toxic skin eruption 16.59 9.78 33 293743 12354 46379932
Liver disorder 16.56 9.78 152 293624 37094 46355192
Hyperbilirubinaemia 16.54 9.78 25 293751 10413 46381873
Pharyngitis 16.51 9.78 56 293720 17527 46374759
Femur fracture 16.45 9.78 151 293625 36846 46355440
Drug use disorder 16.44 9.78 46 293730 2689 46389597
Cytomegalovirus viraemia 16.37 9.78 4 293772 4474 46387812
Tardive dyskinesia 16.35 9.78 92 293684 7451 46384835
Asthma 16.21 9.78 445 293331 91097 46301189
Injection site mass 16.11 9.78 155 293621 14885 46377401
Atonic urinary bladder 16.09 9.78 9 293767 85 46392201
Obstructive airways disorder 16.08 9.78 38 293738 13374 46378912
Cardiac arrest 16.03 9.78 709 293067 89690 46302596
Metabolic encephalopathy 16.03 9.78 72 293704 5331 46386955
Panniculitis 15.89 9.78 8 293768 5696 46386590
Bipolar disorder 15.87 9.78 88 293688 7089 46385197
Angioedema 15.63 9.78 165 293611 39177 46353109
Sensory loss 15.51 9.78 85 293691 6817 46385469
Palmar-plantar erythrodysaesthesia syndrome 15.47 9.78 71 293705 20380 46371906
Epstein-Barr virus infection 15.46 9.78 12 293764 6772 46385514
Aspartate aminotransferase increased 15.42 9.78 377 293399 78323 46313963
Hypokinesia 15.42 9.78 123 293653 11199 46381087
Proteinuria 15.36 9.78 53 293723 16500 46375786
Lupus-like syndrome 15.34 9.78 16 293760 7828 46384458
Head banging 15.33 9.78 16 293760 408 46391878
Suspected suicide 15.27 9.78 64 293712 4597 46387689
Therapy cessation 15.27 9.78 244 293532 26385 46365901
Pericardial effusion 15.26 9.78 96 293680 25447 46366839
Economic problem 15.25 9.78 37 293739 1983 46390303
Uterine perforation 15.16 9.78 14 293762 7253 46385033
Exposure via ingestion 14.98 9.78 52 293724 3415 46388871
Urticaria 14.98 9.78 598 293178 117294 46274992
Ejection fraction decreased 14.96 9.78 60 293716 17877 46374409
Rash erythematous 14.92 9.78 141 293635 34209 46358077
Hostility 14.92 9.78 29 293747 1333 46390953
Postmortem blood drug level abnormal 14.87 9.78 14 293762 314 46391972
Exostosis 14.81 9.78 113 293663 10150 46382136
Skin reaction 14.80 9.78 29 293747 10917 46381369
Disturbance in attention 14.79 9.78 280 293496 31280 46361006
Oligohydramnios 14.72 9.78 8 293768 5457 46386829
Ventricular tachycardia 14.63 9.78 56 293720 16911 46375375
Facial pain 14.59 9.78 90 293686 7535 46384751
Low birth weight baby 14.57 9.78 8 293768 5426 46386860
Pulmonary fibrosis 14.47 9.78 71 293705 20021 46372265
Hypercholesterolaemia 14.36 9.78 32 293744 11498 46380788
Acute myocardial infarction 14.32 9.78 130 293646 31794 46360492
Tooth loss 14.21 9.78 81 293695 6592 46385694
Jaundice cholestatic 14.09 9.78 7 293769 5022 46387264
Myotonia 14.08 9.78 10 293766 148 46392138
Disorganised speech 14.06 9.78 22 293754 849 46391437
Deprescribing error 14.05 9.78 6 293770 29 46392257
Agitation 14.00 9.78 452 293324 54963 46337323
Blood lactic acid 13.99 9.78 9 293767 112 46392174
Contusion 13.97 9.78 679 293097 86808 46305478
Tubulointerstitial nephritis 13.96 9.78 47 293729 14741 46377545
Carpal tunnel syndrome 13.94 9.78 157 293619 15702 46376584
Tumour lysis syndrome 13.88 9.78 15 293761 7221 46385065
Bronchopulmonary aspergillosis 13.87 9.78 16 293760 7480 46384806
Acute coronary syndrome 13.82 9.78 27 293749 10177 46382109
Mucocutaneous haemorrhage 13.82 9.78 7 293769 53 46392233
Hepatitis cholestatic 13.77 9.78 13 293763 6664 46385622
Osteosclerosis 13.72 9.78 51 293725 3465 46388821
Metabolic acidosis 13.70 9.78 167 293609 38613 46353673
Complication of device insertion 13.67 9.78 7 293769 4937 46387349
Pulmonary embolism 13.54 9.78 552 293224 108033 46284253
Congenital absence of vertebra 13.54 9.78 5 293771 15 46392271
Coma 13.48 9.78 471 293305 57878 46334408
Pancreatitis chronic 13.46 9.78 33 293743 1780 46390506
Haemolysis 13.46 9.78 11 293765 6048 46386238
No adverse event 13.42 9.78 144 293632 34087 46358199
Breakthrough pain 13.20 9.78 25 293751 1127 46391159
Atrioventricular block 13.20 9.78 14 293762 6797 46385489
Arthralgia 13.15 9.78 2054 291722 362549 46029737
Internal hernia 13.14 9.78 6 293770 35 46392251
Blood pressure increased 13.13 9.78 657 293119 126009 46266277
Cervical spinal stenosis 13.09 9.78 34 293742 1901 46390385
Glycosylated haemoglobin decreased 13.07 9.78 16 293760 488 46391798
Wound 13.05 9.78 190 293586 42612 46349674
Foot fracture 13.00 9.78 184 293592 19398 46372888
Forced expiratory volume decreased 13.00 9.78 8 293768 5096 46387190
Gastroenteritis 12.98 9.78 94 293682 24125 46368161
Postmortem blood drug level increased 12.98 9.78 15 293761 430 46391856
Hypocalcaemia 12.93 9.78 107 293669 26678 46365608
Unintended pregnancy 12.92 9.78 10 293766 5650 46386636
Blood creatine phosphokinase increased 12.83 9.78 112 293664 27612 46364674
Enterocolitis 12.73 9.78 12 293764 6156 46386130
Movement disorder 12.71 9.78 162 293614 16687 46375599
Sinusitis 12.71 9.78 677 293099 129091 46263195
Eyelid oedema 12.69 9.78 29 293747 10328 46381958
Peripheral nerve operation 12.67 9.78 4 293772 6 46392280
Cervicogenic headache 12.67 9.78 4 293772 6 46392280
Haematotoxicity 12.61 9.78 15 293761 6918 46385368
Phobia 12.50 9.78 13 293763 330 46391956
Road traffic accident 12.45 9.78 214 293562 23477 46368809
Lymphoma 12.42 9.78 27 293749 9786 46382500
Skin necrosis 12.33 9.78 22 293754 8582 46383704
Arrhythmia 12.32 9.78 150 293626 34691 46357595
Adverse drug reaction 12.31 9.78 366 293410 43996 46348290
Heteroplasia 12.30 9.78 4 293772 7 46392279
Turbinectomy 12.22 9.78 3 293773 0 46392286
Muscle relaxant drug level above therapeutic 12.22 9.78 3 293773 0 46392286
Premature ageing 12.22 9.78 3 293773 0 46392286
CSF neutrophil count increased 12.22 9.78 3 293773 0 46392286
Bradyphrenia 12.22 9.78 74 293702 6156 46386130
Schizophrenia 12.20 9.78 22 293754 8546 46383740
Dysgraphia 12.18 9.78 42 293734 2750 46389536
Injection site atrophy 12.12 9.78 16 293760 527 46391759
Somnambulism 11.98 9.78 63 293713 4974 46387312
Infection 11.97 9.78 703 293073 132889 46259397
Lymphoedema 11.97 9.78 94 293682 8518 46383768
Asthenia 11.96 9.78 2177 291599 308898 46083388
Narcolepsy 11.88 9.78 24 293752 1135 46391151
Drug abuser 11.88 9.78 46 293730 3187 46389099
Altered state of consciousness 11.86 9.78 92 293684 23256 46369030
Weight increased 11.83 9.78 1195 292581 163278 46229008
Acute generalised exanthematous pustulosis 11.80 9.78 26 293750 9379 46382907
Withdrawal catatonia 11.78 9.78 6 293770 46 46392240
Spinal cord injury 11.78 9.78 16 293760 542 46391744
Depressed level of consciousness 11.75 9.78 387 293389 47182 46345104
Lung adenocarcinoma stage I 11.74 9.78 5 293771 24 46392262
Arteriovenous malformation 11.73 9.78 25 293751 1228 46391058
Pollakiuria 11.63 9.78 216 293560 24045 46368241
Peritonitis bacterial 11.63 9.78 23 293753 8630 46383656
Cholecystitis chronic 11.61 9.78 31 293745 10468 46381818
Shock 11.61 9.78 85 293691 21760 46370526
Food allergy 11.58 9.78 16 293760 6917 46385369
Burns second degree 11.53 9.78 18 293758 693 46391593
Soft tissue disorder 11.47 9.78 6 293770 4180 46388106
Copper deficiency 11.46 9.78 6 293770 49 46392237
Concomitant disease aggravated 11.44 9.78 20 293756 7862 46384424
Empty sella syndrome 11.41 9.78 5 293771 26 46392260
Haemangioma of skin 11.40 9.78 12 293764 309 46391977
Laryngeal oedema 11.39 9.78 10 293766 5309 46386977
Upper airway resistance syndrome 11.35 9.78 4 293772 10 46392276
Ankylosing spondylitis 11.35 9.78 77 293699 6660 46385626
Septic encephalopathy 11.31 9.78 7 293769 81 46392205
JC polyomavirus test positive 11.25 9.78 21 293755 936 46391350
Disease progression 11.19 9.78 465 293311 90835 46301451
Complication of device removal 11.15 9.78 4 293772 3486 46388800
Electroencephalogram abnormal 11.12 9.78 50 293726 3704 46388582
Brain malformation 11.11 9.78 5 293771 28 46392258
Porphyria 11.06 9.78 8 293768 122 46392164
Hypomagnesaemia 11.06 9.78 88 293688 22122 46370164
Panic attack 11.06 9.78 184 293592 20058 46372228
Toe operation 11.05 9.78 16 293760 576 46391710
Hypertension 10.96 9.78 1075 292701 195281 46197005
Pneumonitis 10.96 9.78 120 293656 28300 46363986
Disorientation 10.90 9.78 307 293469 36611 46355675
Myocarditis 10.90 9.78 20 293756 7719 46384567
Hepatitis acute 10.90 9.78 22 293754 8192 46384094
Connective tissue inflammation 10.88 9.78 6 293770 55 46392231
Acne 10.83 9.78 77 293699 19842 46372444
Confusional arousal 10.82 9.78 7 293769 88 46392198
Lymphadenopathy 10.79 9.78 147 293629 33341 46358945
Metastases to lung 10.79 9.78 33 293743 10663 46381623
Tachypnoea 10.75 9.78 50 293726 14301 46377985
Uveitis 10.75 9.78 24 293752 8617 46383669
Walking aid user 10.71 9.78 59 293717 4741 46387545
Femoral artery dissection 10.70 9.78 5 293771 31 46392255
Hepatitis fulminant 10.70 9.78 4 293772 3398 46388888
Laryngeal dyspnoea 10.69 9.78 8 293768 129 46392157
Pseudomonas infection 10.65 9.78 29 293747 9729 46382557
Pulmonary arterial hypertension 10.60 9.78 108 293668 25820 46366466
Muscle injury 10.60 9.78 9 293767 4857 46387429
Gastrointestinal inflammation 10.60 9.78 7 293769 4294 46387992
Inflammation 10.58 9.78 230 293546 48551 46343735
Dermatitis bullous 10.55 9.78 20 293756 7623 46384663
Plasma cell myeloma 10.52 9.78 360 293416 44118 46348168
Lip oedema 10.50 9.78 4 293772 3360 46388926
Upper gastrointestinal haemorrhage 10.47 9.78 62 293714 16676 46375610
Infective pulmonary exacerbation of cystic fibrosis 10.44 9.78 34 293742 10773 46381513
Ischaemic stroke 10.43 9.78 62 293714 16660 46375626
Hypoxic-ischaemic encephalopathy 10.42 9.78 52 293724 4021 46388265
Right ventricular failure 10.40 9.78 59 293717 16034 46376252
Toxicologic test abnormal 10.38 9.78 17 293759 682 46391604
Gastric bypass 10.37 9.78 25 293751 1334 46390952
Skin toxicity 10.37 9.78 5 293771 3649 46388637
Osteopenia 10.33 9.78 157 293619 16804 46375482
Radiculopathy 10.28 9.78 60 293716 4925 46387361
Metastases to bone 10.28 9.78 66 293710 17410 46374876
Bladder disorder 10.25 9.78 78 293698 7000 46385286
Stress cardiomyopathy 10.20 9.78 21 293755 7763 46384523
International normalised ratio increased 10.19 9.78 221 293555 46662 46345624
Naevus haemorrhage 10.18 9.78 7 293769 98 46392188
Subarachnoid haemorrhage 10.15 9.78 36 293740 11117 46381169
Micturition urgency 10.14 9.78 84 293692 7733 46384553
Malignant polyp 10.12 9.78 9 293767 187 46392099
Pathogen resistance 10.11 9.78 14 293762 6046 46386240
Accidental overdose 10.09 9.78 180 293596 19886 46372400
Sciatica 10.06 9.78 172 293604 18848 46373438
Dry eye 10.06 9.78 256 293520 30066 46362220
Drug screen false positive 10.01 9.78 19 293757 858 46391428
Substance use 9.99 9.78 13 293763 422 46391864
Blood potassium increased 9.93 9.78 156 293620 16811 46375475
Bronchospasm 9.92 9.78 58 293718 15649 46376637
Pruritus 9.90 9.78 1355 292421 240997 46151289
Parapsoriasis 9.89 9.78 7 293769 103 46392183
Normal newborn 9.87 9.78 14 293762 5987 46386299
Osteoporosis 9.84 9.78 188 293588 40420 46351866
Cystitis haemorrhagic 9.84 9.78 5 293771 3542 46388744
Pulmonary toxicity 9.84 9.78 9 293767 4684 46387602
Sudden death 9.82 9.78 29 293747 9475 46382811

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 988.10 10.22 1509 159969 67010 29723990
Drug ineffective for unapproved indication 536.26 10.22 455 161023 10425 29780575
Completed suicide 312.99 10.22 1211 160267 98281 29692719
Myoclonus 224.37 10.22 316 161162 12996 29778004
Neuropathy peripheral 168.02 10.22 789 160689 69686 29721314
Somnolence 157.08 10.22 975 160503 95788 29695212
Toxicity to various agents 139.03 10.22 1513 159965 175670 29615330
Drug withdrawal syndrome 138.11 10.22 320 161158 19489 29771511
Interstitial lung disease 132.69 10.22 80 161398 60117 29730883
Pain 125.77 10.22 1453 160025 171188 29619812
Fall 125.14 10.22 1514 159964 180358 29610642
Multiple sclerosis relapse 111.74 10.22 206 161272 10656 29780344
Sedation 104.94 10.22 256 161222 16117 29774883
Mental status changes 101.75 10.22 433 161045 36646 29754354
Neuralgia 100.83 10.22 193 161285 10273 29780727
Febrile neutropenia 93.89 10.22 280 161198 106413 29684587
Memory impairment 90.57 10.22 419 161059 36755 29754245
Hypoaesthesia 87.61 10.22 546 160932 53684 29737316
Cytomegalovirus infection 87.30 10.22 12 161466 23662 29767338
Confusional state 84.29 10.22 1103 160375 133731 29657269
Tremor 84.12 10.22 694 160784 74669 29716331
Hepatic function abnormal 82.70 10.22 63 161415 41882 29749118
Pain in extremity 80.70 10.22 929 160549 109292 29681708
Depression 80.57 10.22 793 160685 89644 29701356
Cardiac failure 78.46 10.22 212 161266 83206 29707794
Drug dependence 78.37 10.22 273 161205 21022 29769978
Anaemia 78.04 10.22 731 160747 207261 29583739
Withdrawal syndrome 76.50 10.22 180 161298 11070 29779930
Multiple organ dysfunction syndrome 76.35 10.22 141 161337 63346 29727654
Gait disturbance 75.26 10.22 673 160805 74104 29716896
Drug abuse 74.74 10.22 723 160755 81349 29709651
Insomnia 73.92 10.22 799 160679 92537 29698463
Suicidal ideation 70.27 10.22 382 161096 35732 29755268
Pyrexia 68.36 10.22 1147 160331 293342 29497658
Thrombocytopenia 65.97 10.22 450 161028 136594 29654406
Euphoric mood 65.21 10.22 97 161381 4193 29786807
Balance disorder 65.03 10.22 377 161101 36116 29754884
Product complaint 63.38 10.22 113 161365 5693 29785307
Renal impairment 63.01 10.22 237 161241 83947 29707053
Accidental death 62.24 10.22 66 161412 2013 29788987
Drug resistance 61.93 10.22 16 161462 20117 29770883
Muscle spasms 61.90 10.22 577 160901 64261 29726739
Respiratory arrest 58.62 10.22 312 161166 28946 29762054
Obsessive-compulsive disorder 57.81 10.22 90 161388 4051 29786949
General physical health deterioration 52.75 10.22 319 161159 99625 29691375
C-reactive protein increased 50.98 10.22 98 161380 43375 29747625
Burning sensation 48.79 10.22 197 161281 16277 29774723
Feeling abnormal 48.72 10.22 494 160984 56262 29734738
Anxiety 48.70 10.22 717 160761 89154 29701846
Disseminated intravascular coagulation 48.08 10.22 30 161448 22141 29768859
Neutropenia 47.58 10.22 453 161025 128087 29662913
Alanine aminotransferase increased 47.58 10.22 222 161256 74054 29716946
Amnesia 45.78 10.22 255 161223 24066 29766934
Dizziness 45.06 10.22 1372 160106 193537 29597463
Back disorder 44.17 10.22 99 161379 5895 29785105
Bone marrow failure 43.55 10.22 58 161420 29727 29761273
Septic shock 43.21 10.22 186 161292 63421 29727579
Therapeutic product effect variable 43.19 10.22 45 161433 1344 29789656
Paraesthesia 42.47 10.22 464 161014 53863 29737137
Vision blurred 42.36 10.22 377 161101 41439 29749561
Mucosal inflammation 41.97 10.22 62 161416 30432 29760568
Multiple sclerosis 41.73 10.22 109 161369 7158 29783842
Prescription drug used without a prescription 39.45 10.22 41 161437 1221 29789779
Inadequate analgesia 39.41 10.22 60 161418 2648 29788352
Congenital multiplex arthrogryposis 39.29 10.22 13 161465 31 29790969
Dyspnoea 38.22 10.22 1441 160037 331854 29459146
Overdose 38.18 10.22 653 160825 83684 29707316
Hepatic failure 37.97 10.22 79 161399 33964 29757036
Drug reaction with eosinophilia and systemic symptoms 37.22 10.22 60 161418 28428 29762572
Dysarthria 36.27 10.22 285 161193 30205 29760795
Disinhibition 35.28 10.22 48 161430 1909 29789091
Muscle spasticity 35.26 10.22 83 161395 5105 29785895
Myokymia 35.15 10.22 14 161464 66 29790934
Parasomnia 34.85 10.22 21 161457 273 29790727
Hypokalaemia 33.94 10.22 147 161331 50045 29740955
Haemophagocytic lymphohistiocytosis 33.75 10.22 6 161472 9785 29781215
Diabetic neuropathy 33.31 10.22 69 161409 3890 29787110
Jaundice 33.27 10.22 79 161399 32407 29758593
Full blood count decreased 33.13 10.22 170 161308 15547 29775453
Drug tolerance 33.03 10.22 49 161429 2113 29788887
Renal failure 32.91 10.22 493 160985 128473 29662527
Cerebral haemorrhage 32.87 10.22 81 161397 32806 29758194
Back pain 32.85 10.22 754 160724 101842 29689158
Hallucination 32.55 10.22 406 161072 48653 29742347
Nightmare 32.31 10.22 140 161338 11936 29779064
Blood bilirubin increased 32.28 10.22 96 161382 36540 29754460
Antipsychotic drug level below therapeutic 31.59 10.22 38 161440 1334 29789666
Malignant neoplasm progression 31.53 10.22 244 161234 72043 29718957
Atrial fibrillation 31.27 10.22 403 161075 107721 29683279
Anorgasmia 30.86 10.22 26 161452 589 29790411
Melaena 30.80 10.22 82 161396 32355 29758645
Hyperreflexia 30.66 10.22 55 161423 2784 29788216
Muscle twitching 30.39 10.22 105 161373 8050 29782950
Sciatica 30.18 10.22 77 161401 4984 29786016
Peripheral swelling 29.89 10.22 479 160999 60595 29730405
Acute kidney injury 29.80 10.22 1191 160287 272651 29518349
Sweat gland disorder 29.36 10.22 14 161464 109 29790891
Product dose omission issue 29.20 10.22 673 160805 90958 29700042
Peritonitis 28.89 10.22 44 161434 21331 29769669
Nerve injury 28.72 10.22 55 161423 2928 29788072
Infusion related reaction 28.54 10.22 117 161361 40447 29750553
Trigeminal neuralgia 28.03 10.22 29 161449 859 29790141
Off label use 27.81 10.22 1081 160397 248209 29542791
Aspartate aminotransferase increased 27.69 10.22 214 161264 63208 29727792
Asterixis 27.57 10.22 34 161444 1225 29789775
Bronchopulmonary aspergillosis 27.51 10.22 16 161462 12268 29778732
Tooth disorder 27.48 10.22 110 161368 9051 29781949
Fatigue 27.28 10.22 2043 159435 318630 29472370
Increased appetite 27.04 10.22 79 161399 5538 29785462
Ascites 26.94 10.22 101 161377 35820 29755180
Contraindicated product administered 26.80 10.22 32 161446 17199 29773801
Foetal exposure during pregnancy 26.79 10.22 105 161373 36766 29754234
Neutrophil count decreased 26.52 10.22 128 161350 42326 29748674
Aspergillus infection 26.35 10.22 11 161467 10203 29780797
Adverse drug reaction 26.24 10.22 214 161264 22931 29768069
Graft versus host disease 26.08 10.22 11 161467 10139 29780861
Delirium tremens 25.80 10.22 22 161456 507 29790493
Bradyphrenia 25.49 10.22 62 161416 3895 29787105
Spinal operation 25.47 10.22 45 161433 2251 29788749
Pneumocystis jirovecii pneumonia 25.37 10.22 33 161445 17087 29773913
Nervousness 25.19 10.22 128 161350 11660 29779340
Proteinuria 25.10 10.22 30 161448 16115 29774885
Cholestasis 24.51 10.22 62 161416 24888 29766112
Bradypnoea 24.41 10.22 40 161438 1881 29789119
Hyperaesthesia 24.11 10.22 57 161421 3516 29787484
Respiratory depression 23.95 10.22 124 161354 11379 29779621
Depressed level of consciousness 23.94 10.22 313 161165 37909 29753091
Suicidal behaviour 23.94 10.22 33 161445 1329 29789671
Localised infection 23.86 10.22 141 161337 13596 29777404
Colitis 23.54 10.22 86 161392 30734 29760266
Intervertebral disc degeneration 23.53 10.22 72 161406 5179 29785821
Ataxia 23.48 10.22 123 161355 11339 29779661
Personality change 23.41 10.22 66 161412 4534 29786466
Eosinophilia 23.41 10.22 53 161425 22107 29768893
Lethargy 23.26 10.22 320 161158 39199 29751801
Anger 23.24 10.22 120 161358 11000 29780000
Constipation 23.22 10.22 784 160694 112122 29678878
Angioedema 23.06 10.22 101 161377 34283 29756717
Gamma-glutamyltransferase increased 23.01 10.22 81 161397 29269 29761731
Acute myocardial infarction 22.93 10.22 179 161299 52760 29738240
Venoocclusive liver disease 22.91 10.22 4 161474 6609 29784391
Gait inability 22.89 10.22 177 161301 18664 29772336
Antidepressant drug level above therapeutic 22.68 10.22 13 161465 153 29790847
Muscular weakness 22.66 10.22 475 161003 63170 29727830
Cerebral infarction 22.60 10.22 70 161408 26303 29764697
Affective disorder 22.53 10.22 51 161427 3057 29787943
Cholangitis 22.51 10.22 7 161471 7795 29783205
Gastrointestinal haemorrhage 22.31 10.22 316 161162 83130 29707870
Erythema 22.26 10.22 289 161189 77162 29713838
Coordination abnormal 22.14 10.22 88 161390 7217 29783783
Transplant rejection 22.06 10.22 11 161467 9195 29781805
Rheumatoid arthritis 21.97 10.22 131 161347 41066 29749934
Neonatal toxicity 21.95 10.22 8 161470 28 29790972
Haematuria 21.63 10.22 147 161331 44687 29746313
Acute myeloid leukaemia 21.62 10.22 40 161438 17966 29773034
Mood altered 21.58 10.22 95 161383 8155 29782845
Toxic epidermal necrolysis 21.41 10.22 40 161438 17900 29773100
Pneumonitis 21.37 10.22 76 161402 27378 29763622
Facial pain 21.24 10.22 36 161442 1741 29789259
Colitis ulcerative 21.20 10.22 28 161450 14406 29776594
Encephalopathy neonatal 21.12 10.22 8 161470 32 29790968
Hypernatraemia 21.09 10.22 7 161471 7477 29783523
Hallucination, visual 21.06 10.22 154 161324 15959 29775041
Haematotoxicity 20.79 10.22 4 161474 6166 29784834
Plasma cell myeloma 20.69 10.22 404 161074 53058 29737942
Hypometabolism 20.56 10.22 8 161470 35 29790965
Labelled drug-drug interaction medication error 20.54 10.22 16 161462 10522 29780478
Feeding intolerance 20.43 10.22 9 161469 57 29790943
Acute respiratory distress syndrome 20.32 10.22 62 161416 23410 29767590
Transaminases increased 20.28 10.22 62 161416 23395 29767605
Sleep apnoea syndrome 20.28 10.22 158 161320 16699 29774301
Pathogen resistance 20.23 10.22 10 161468 8400 29782600
Myocardial infarction 20.21 10.22 519 160959 125106 29665894
Impaired driving ability 20.16 10.22 43 161435 2475 29788525
Anaphylactic reaction 20.13 10.22 80 161398 27902 29763098
Phantom limb syndrome 20.12 10.22 15 161463 283 29790717
Metabolic acidosis 20.04 10.22 119 161359 37342 29753658
Circulatory collapse 20.03 10.22 50 161428 20164 29770836
Epistaxis 19.88 10.22 186 161292 52795 29738205
Erectile dysfunction 19.79 10.22 166 161312 17936 29773064
Myocarditis 19.77 10.22 15 161463 9996 29781004
Hepatic enzyme increased 19.77 10.22 103 161375 33391 29757609
Joint hyperextension 19.71 10.22 8 161470 40 29790960
Binocular eye movement disorder 19.55 10.22 8 161470 41 29790959
Pancytopenia 19.38 10.22 332 161146 84720 29706280
Rash maculo-papular 19.36 10.22 71 161407 25347 29765653
Asthma 19.30 10.22 115 161363 36059 29754941
Cognitive disorder 19.27 10.22 204 161274 23486 29767514
Pleural effusion 19.26 10.22 282 161196 73784 29717216
Hostility 19.24 10.22 24 161454 875 29790125
Dyskinesia 19.18 10.22 191 161287 21643 29769357
Treatment failure 19.17 10.22 109 161369 34570 29756430
Conversion disorder 19.12 10.22 16 161462 359 29790641
Cerebral disorder 19.11 10.22 41 161437 2369 29788631
Leukopenia 19.05 10.22 202 161276 55957 29735043
Hepatocellular injury 18.85 10.22 72 161406 25399 29765601
Post transplant lymphoproliferative disorder 18.84 10.22 3 161475 5303 29785697
Pulmonary alveolar haemorrhage 18.82 10.22 6 161472 6575 29784425
Disorientation 18.73 10.22 255 161223 31163 29759837
Restless legs syndrome 18.64 10.22 80 161398 6792 29784208
Thinking abnormal 18.60 10.22 67 161411 5244 29785756
Posterior reversible encephalopathy syndrome 18.58 10.22 12 161466 8695 29782305
Intentional product misuse 18.52 10.22 276 161202 34391 29756609
Drug eruption 18.44 10.22 42 161436 17484 29773516
Hyperbilirubinaemia 18.32 10.22 40 161438 16902 29774098
Feeling drunk 18.30 10.22 32 161446 1587 29789413
Opisthotonus 18.29 10.22 16 161462 382 29790618
Precancerous skin lesion 18.25 10.22 19 161459 567 29790433
Analgesic drug level above therapeutic 18.05 10.22 13 161465 232 29790768
Infective pulmonary exacerbation of cystic fibrosis 18.04 10.22 12 161466 8560 29782440
Serotonin syndrome 17.95 10.22 161 161317 17730 29773270
Fibromyalgia 17.92 10.22 42 161436 2576 29788424
Metastases to liver 17.79 10.22 23 161455 11942 29779058
Ear deformity acquired 17.70 10.22 5 161473 5 29790995
Epstein-Barr virus infection 17.66 10.22 7 161471 6699 29784301
Cough 17.65 10.22 529 160949 125113 29665887
Blood creatinine increased 17.63 10.22 367 161111 91008 29699992
Blood lactate dehydrogenase increased 17.42 10.22 55 161423 20546 29770454
Musculoskeletal disorder 17.40 10.22 62 161416 4827 29786173
Hand deformity 17.38 10.22 34 161444 1839 29789161
Migraine 17.37 10.22 124 161354 12750 29778250
Nephropathy toxic 17.37 10.22 19 161459 10620 29780380
Seizure 17.34 10.22 672 160806 97803 29693197
Intervertebral disc protrusion 17.31 10.22 97 161381 9174 29781826
Blood creatine phosphokinase increased 17.29 10.22 152 161326 43696 29747304
Mental impairment 17.28 10.22 97 161381 9180 29781820
Liver disorder 17.20 10.22 92 161386 29630 29761370
Delirium 17.08 10.22 311 161167 40320 29750680
Hepatocellular carcinoma 17.01 10.22 16 161462 9594 29781406
Tumour lysis syndrome 16.96 10.22 27 161451 12858 29778142
Idiopathic neutropenia 16.91 10.22 4 161474 0 29791000
Agranulocytosis 16.90 10.22 61 161417 21881 29769119
Haemolysis 16.79 10.22 9 161469 7222 29783778
Stomatitis 16.64 10.22 125 161353 37154 29753846
Tubulointerstitial nephritis 16.40 10.22 46 161432 17845 29773155
Haemoglobin decreased 16.37 10.22 479 160999 113619 29677381
Immune reconstitution inflammatory syndrome 16.29 10.22 15 161463 9086 29781914
Urinary incontinence 16.27 10.22 151 161327 16789 29774211
Osteomyelitis 16.24 10.22 135 161343 14546 29776454
Heat exhaustion 16.07 10.22 9 161469 101 29790899
Aggression 16.05 10.22 284 161194 36623 29754377
Agitation 15.94 10.22 393 161085 53680 29737320
Appendicolith 15.75 10.22 22 161456 897 29790103
Metabolic encephalopathy 15.73 10.22 51 161427 3784 29787216
Shock haemorrhagic 15.69 10.22 18 161460 9847 29781153
Gingival atrophy 15.68 10.22 7 161471 46 29790954
Acute coronary syndrome 15.56 10.22 31 161447 13542 29777458
Ischaemic stroke 15.55 10.22 41 161437 16234 29774766
Sopor 15.50 10.22 107 161371 10884 29780116
Diplopia 15.43 10.22 127 161351 13645 29777355
Artery dissection 15.41 10.22 9 161469 110 29790890
Nephrotic syndrome 15.37 10.22 9 161469 6876 29784124
Thrombosis 15.29 10.22 316 161162 41915 29749085
Quality of life decreased 15.25 10.22 45 161433 3172 29787828
Dysphemia 15.12 10.22 28 161450 1453 29789547
Herpes zoster 15.07 10.22 236 161242 29707 29761293
Pulmonary toxicity 15.07 10.22 3 161475 4513 29786487
Drug screen negative 15.01 10.22 12 161466 252 29790748
Encephalitis 14.96 10.22 8 161470 6428 29784572
Prescribed overdose 14.95 10.22 88 161390 8473 29782527
Schizophrenia 14.95 10.22 16 161462 9032 29781968
Ventricular tachycardia 14.87 10.22 72 161406 23790 29767210
Tuberculosis 14.83 10.22 13 161465 8064 29782936
Body height decreased 14.72 10.22 49 161429 3685 29787315
Pulmonary tuberculosis 14.67 10.22 4 161474 4853 29786147
Muscle tightness 14.67 10.22 56 161422 4507 29786493
Enterocolitis 14.56 10.22 9 161469 6678 29784322
Rhabdomyolysis 14.54 10.22 248 161230 63332 29727668
Irritability 14.53 10.22 189 161289 22861 29768139
Acute hepatic failure 14.44 10.22 26 161452 11801 29779199
Thoracic vertebral fracture 14.42 10.22 27 161451 1413 29789587
Back injury 14.41 10.22 47 161431 3498 29787502
Synovitis 14.35 10.22 19 161459 9764 29781236
Foot fracture 14.08 10.22 52 161426 4120 29786880
Hyperkalaemia 13.98 10.22 261 161217 65749 29725251
Acute pulmonary oedema 13.92 10.22 12 161466 7503 29783497
Weight increased 13.85 10.22 514 160964 74399 29716601
Spinal stenosis 13.81 10.22 53 161425 4276 29786724
Blood pressure decreased 13.76 10.22 175 161303 46900 29744100
Shock 13.65 10.22 70 161408 22789 29768211
Blood urea increased 13.64 10.22 106 161372 31275 29759725
Mucosal atrophy 13.45 10.22 7 161471 67 29790933
Personality disorder 13.28 10.22 23 161455 1132 29789868
Free androgen index decreased 13.20 10.22 5 161473 20 29790980
Foetal disorder 13.19 10.22 17 161461 641 29790359
Tachycardia 13.12 10.22 300 161178 73439 29717561
Abnormal sleep-related event 13.10 10.22 15 161463 499 29790501
Mucormycosis 13.07 10.22 6 161472 5262 29785738
Mental disorder 12.97 10.22 120 161358 13329 29777671
Injection site mass 12.93 10.22 57 161421 4896 29786104
Autoimmune haemolytic anaemia 12.92 10.22 3 161475 4056 29786944
Lung disorder 12.89 10.22 108 161370 31361 29759639
Inflammation 12.85 10.22 68 161410 21958 29769042
Abdominal discomfort 12.75 10.22 349 161129 48442 29742558
Therapeutic response unexpected 12.75 10.22 87 161391 8816 29782184
Facial wasting 12.72 10.22 9 161469 156 29790844
Pancreatic fibrosis 12.69 10.22 3 161475 0 29791000
Severe myoclonic epilepsy of infancy 12.69 10.22 3 161475 0 29791000
Nasal odour 12.69 10.22 3 161475 0 29791000
Left ventricular dysfunction 12.62 10.22 17 161461 8674 29782326
Dysaesthesia 12.62 10.22 33 161445 2168 29788832
Hypoosmolar state 12.62 10.22 7 161471 77 29790923
Rectal haemorrhage 12.53 10.22 124 161354 34815 29756185
Eye injury 12.51 10.22 13 161465 387 29790613
Hepatitis 12.50 10.22 70 161408 22286 29768714
Hypersomnia 12.49 10.22 104 161374 11212 29779788
Dependence on respirator 12.48 10.22 5 161473 24 29790976
Palmar-plantar erythrodysaesthesia syndrome 12.36 10.22 40 161438 14830 29776170
Violence-related symptom 12.35 10.22 15 161463 532 29790468
Facet joint syndrome 12.35 10.22 10 161468 214 29790786
Candida infection 12.31 10.22 42 161436 15320 29775680
Radiculopathy 12.30 10.22 37 161441 2636 29788364
Hyperuricaemia 12.30 10.22 13 161465 7381 29783619
Neutrophil count increased 12.20 10.22 42 161436 15281 29775719
Hypoalbuminaemia 12.15 10.22 26 161452 11066 29779934
Stevens-Johnson syndrome 12.12 10.22 51 161427 17505 29773495
Hepatitis B 12.12 10.22 9 161469 6063 29784937
Dysphoria 12.11 10.22 32 161446 2116 29788884
Anaphylactic shock 12.08 10.22 37 161441 13956 29777044
Cytomegalovirus viraemia 12.08 10.22 8 161470 5721 29785279
Toxic skin eruption 11.91 10.22 26 161452 10989 29780011
Seborrhoeic keratosis 11.89 10.22 20 161458 961 29790039
Complex regional pain syndrome 11.87 10.22 14 161464 481 29790519
Laboratory test abnormal 11.84 10.22 145 161333 17297 29773703
Pneumothorax 11.83 10.22 46 161432 16147 29774853
Drug abuser 11.76 10.22 51 161427 4350 29786650
Hepatotoxicity 11.74 10.22 54 161424 18091 29772909
Panic disorder 11.73 10.22 22 161456 1153 29789847
Foetal heart rate disorder 11.71 10.22 5 161473 29 29790971
Psoriasis 11.69 10.22 160 161318 42346 29748654
Sensory disturbance 11.65 10.22 62 161416 5749 29785251
Slow speech 11.64 10.22 20 161458 978 29790022
Hypertriglyceridaemia 11.60 10.22 16 161462 8082 29782918
Hyperthyroidism 11.60 10.22 16 161462 8082 29782918
Mouth ulceration 11.51 10.22 25 161453 10584 29780416
Drug effective for unapproved indication 11.50 10.22 21 161457 1078 29789922
Hypotension 11.49 10.22 928 160550 199637 29591363
Erysipelas 11.47 10.22 5 161473 4519 29786481
Oesophageal mucosa erythema 11.44 10.22 5 161473 31 29790969
Haemorrhage intracranial 11.44 10.22 42 161436 14990 29776010
Acute graft versus host disease in skin 11.43 10.22 5 161473 4511 29786489
Post herpetic neuralgia 11.39 10.22 20 161458 995 29790005
Breakthrough pain 11.39 10.22 15 161463 578 29790422
Swelling 11.37 10.22 264 161214 35711 29755289
Panic attack 11.36 10.22 83 161395 8598 29782402
Chronic graft versus host disease 11.35 10.22 4 161474 4115 29786885
Fracture 11.32 10.22 63 161415 5943 29785057
Teeth brittle 11.31 10.22 6 161472 60 29790940
Walking disability 11.30 10.22 17 161461 742 29790258
Lymphoedema 11.30 10.22 43 161435 3456 29787544
Dissociative disorder 11.29 10.22 8 161470 139 29790861
Neck pain 11.28 10.22 167 161311 20777 29770223
Nerve compression 11.25 10.22 37 161441 2765 29788235
Lower respiratory tract infection 11.25 10.22 91 161387 26623 29764377
Incoherent 11.21 10.22 48 161430 4070 29786930
Hyperfibrinogenaemia 11.20 10.22 4 161474 13 29790987
Blood alkaline phosphatase increased 11.19 10.22 112 161366 31375 29759625
Nephrogenic systemic fibrosis 11.18 10.22 50 161428 4321 29786679
Dependence 11.07 10.22 22 161456 1204 29789796
Lymphocyte count decreased 11.02 10.22 59 161419 18996 29772004
Hyperglycaemia 10.99 10.22 129 161349 35071 29755929
Genital burning sensation 10.97 10.22 4 161474 14 29790986
Abnormal labour affecting foetus 10.97 10.22 4 161474 14 29790986
Myelosuppression 10.96 10.22 14 161464 7308 29783692
Neurogenic bladder 10.90 10.22 26 161452 1613 29789387
Drug tolerance increased 10.83 10.22 12 161466 385 29790615
Respiratory disorder 10.77 10.22 53 161425 17441 29773559
Second primary malignancy 10.77 10.22 11 161467 6345 29784655
Neck surgery 10.76 10.22 11 161467 321 29790679
Fear of weight gain 10.76 10.22 4 161474 15 29790985
Immunosuppressant drug level increased 10.70 10.22 6 161472 4696 29786304
Lumbar radiculopathy 10.70 10.22 18 161460 865 29790135
Decreased interest 10.69 10.22 31 161447 2164 29788836
Tongue movement disturbance 10.66 10.22 6 161472 68 29790932
Multiple cardiac defects 10.66 10.22 6 161472 68 29790932
Carcinogenicity 10.66 10.22 6 161472 68 29790932
Autonomic nervous system imbalance 10.66 10.22 33 161445 2388 29788612
Lipodystrophy acquired 10.63 10.22 3 161475 3557 29787443
Joint injury 10.63 10.22 67 161411 6610 29784390
Premature baby 10.61 10.22 50 161428 16641 29774359
Disturbance in attention 10.60 10.22 173 161305 21956 29769044
Osteonecrosis of jaw 10.57 10.22 58 161420 18560 29772440
Rib fracture 10.56 10.22 110 161368 12610 29778390
Developmental hip dysplasia 10.54 10.22 10 161468 266 29790734
Incision site complication 10.49 10.22 11 161467 331 29790669
Ventricular septal defect 10.49 10.22 3 161475 3526 29787474
Aphasia 10.47 10.22 155 161323 19284 29771716
Haematochezia 10.46 10.22 126 161352 34096 29756904
Immunodeficiency common variable 10.38 10.22 8 161470 159 29790841
Myelomalacia 10.37 10.22 5 161473 40 29790960
Intervertebral disc injury 10.37 10.22 4 161474 17 29790983
Road traffic accident 10.35 10.22 139 161339 16932 29774068
White blood cell count increased 10.33 10.22 151 161327 39522 29751478
Cardio-respiratory arrest 10.30 10.22 392 161086 56914 29734086
Arthrofibrosis 10.30 10.22 6 161472 73 29790927
Bipolar disorder 10.27 10.22 44 161434 3732 29787268
Dysstasia 10.27 10.22 94 161384 10411 29780589

Pharmacologic Action:

SourceCodeDescription
ATC N03AX12 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Other antiepileptics
FDA PE N0000008486 Decreased Central Nervous System Disorganized Electrical Activity
FDA EPC N0000175753 Anti-epileptic Agent
MeSH PA D000700 Analgesics
MeSH PA D014151 Anti-Anxiety Agents
MeSH PA D000927 Anticonvulsants
MeSH PA D018692 Antimanic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018691 Excitatory Amino Acid Antagonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D018689 Sensory System Agents
MeSH PA D014149 Tranquilizing Agents
CHEBI has role CHEBI:35623 antiepileptic
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:38215 calcium channel blockers
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Postherpetic neuralgia indication 2177002
Restless legs indication 32914008 DOID:0050425
Partial Epilepsy Treatment Adjunct indication
Alcohol use disorder off-label use 7200002
Menopausal night sweats off-label use 42984000
Chronic cough off-label use 68154008
Chronic pain off-label use 82423001
Insomnia off-label use 193462001
Anxiety disorder off-label use 197480006 DOID:2030
Menopausal flushing off-label use 198436008
Fibromyalgia off-label use 203082005 DOID:631
Neuropathic pain off-label use 247398009
Chronic pruritus off-label use 418363000
Refractory pruritis off-label use 418363000
Post-stroke nausea off-label use 422587007
Essential tremor off-label use 609558009 DOID:4990
Intractable hiccups off-label use 716771000
Acute postoperative pain off-label use 107401000119105
Suicidal thoughts contraindication 6471006
Depressive disorder contraindication 35489007
Kidney disease contraindication 90708001 DOID:557

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.02 acidic
pKa2 10.31 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Voltage-dependent calcium channel subunit alpha-2/delta-1 Ion channel MODULATOR IC50 7.26 WOMBAT-PK CHEMBL
Voltage-dependent calcium channel subunit alpha-2/delta-2 Ion channel MODULATOR IC50 6.93 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Large neutral amino acids transporter small subunit 1 Transporter IC50 4.52 WOMBAT-PK
Glutamate receptor ionotropic, NMDA 3A Ion channel WOMBAT-PK
Gamma-aminobutyric acid type B receptor subunit 2 GPCR WOMBAT-PK
Adenosine receptor A1 GPCR WOMBAT-PK
Alpha-2A adrenergic receptor GPCR WOMBAT-PK
Sodium channel protein type 5 subunit alpha Ion channel WOMBAT-PK
Voltage-dependent calcium channel subunit alpha-2/delta-1 Ion channel Ki 6.92 CHEMBL
Uncharacterized protein; Voltage-dependent calcium channel alpha-2 delta subunit Ion channel IC50 7.15 CHEMBL

External reference:

IDSource
4020833 VUID
N0000148345 NUI
D00332 KEGG_DRUG
4020833 VANDF
C0060926 UMLSCUI
CHEBI:42797 CHEBI
GBN PDB_CHEM_ID
CHEMBL940 ChEMBL_ID
DB00996 DRUGBANK_ID
D000077206 MESH_DESCRIPTOR_UI
5483 IUPHAR_LIGAND_ID
5094 INN_ID
6CW7F3G59X UNII
3446 PUBCHEM_CID
196498 RXNORM
2269 MMSL
4770 MMSL
60712 MMSL
d03182 MMSL
004415 NDDF
108402001 SNOMEDCT_US
386845007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Neurontin HUMAN PRESCRIPTION DRUG LABEL 1 0071-0401 TABLET, FILM COATED 800 mg ORAL NDA 31 sections
Neurontin HUMAN PRESCRIPTION DRUG LABEL 1 0071-0513 TABLET, FILM COATED 600 mg ORAL NDA 31 sections
Neurontin HUMAN PRESCRIPTION DRUG LABEL 1 0071-0803 CAPSULE 100 mg ORAL NDA 31 sections
Neurontin HUMAN PRESCRIPTION DRUG LABEL 1 0071-0805 CAPSULE 300 mg ORAL NDA 31 sections
Neurontin HUMAN PRESCRIPTION DRUG LABEL 1 0071-0806 CAPSULE 400 mg ORAL NDA 31 sections
Neurontin HUMAN PRESCRIPTION DRUG LABEL 1 0071-2012 SOLUTION 250 mg ORAL NDA 31 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 0228-2636 TABLET, FILM COATED 600 mg ORAL ANDA 26 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 0228-2637 TABLET, FILM COATED 800 mg ORAL ANDA 26 sections
GABAPENTIN HUMAN PRESCRIPTION DRUG LABEL 1 0440-5562 TABLET, FILM COATED 600 mg ORAL ANDA 24 sections
GABAPENTIN HUMAN PRESCRIPTION DRUG LABEL 1 0440-5563 TABLET, FILM COATED 800 mg ORAL ANDA 24 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 0440-7559 CAPSULE 300 mg ORAL ANDA 14 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 0615-8132 TABLET 800 mg ORAL ANDA 29 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 0615-8230 CAPSULE 100 mg ORAL ANDA 29 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 0615-8231 CAPSULE 300 mg ORAL ANDA 29 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 0615-8232 CAPSULE 400 mg ORAL ANDA 29 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 0615-8233 TABLET 600 mg ORAL ANDA 29 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 0615-8340 CAPSULE 100 mg ORAL ANDA 26 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 0615-8341 CAPSULE 300 mg ORAL ANDA 26 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 0615-8342 CAPSULE 400 mg ORAL ANDA 26 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 0904-6586 TABLET, FILM COATED 800 mg ORAL ANDA 25 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 0904-6665 CAPSULE 100 mg ORAL ANDA 30 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 0904-6666 CAPSULE 300 mg ORAL ANDA 30 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 0904-6667 CAPSULE 400 mg ORAL ANDA 30 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 0904-6823 TABLET, FILM COATED 600 mg ORAL ANDA 30 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 0904-7108 TABLET, FILM COATED 800 mg ORAL ANDA 30 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 10135-644 CAPSULE 100 mg ORAL ANDA 30 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 10135-645 CAPSULE 300 mg ORAL ANDA 30 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 10135-646 CAPSULE 400 mg ORAL ANDA 30 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 10135-647 TABLET 600 mg ORAL ANDA 30 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 10135-648 TABLET 800 mg ORAL ANDA 30 sections