gabapentin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
gabamimetic agents	1264	60142-96-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: gabapentin gabamox gabapen neurontin gabapentine	The mechanism by which gabapentin exerts its analgesic action is unknown, but in animal models of analgesia, gabapentin prevents allodynia (pain-related behavior in response to a normally innocuous stimulus) and hyperalgesia (exaggerated response to painful stimuli). In particular, gabapentin prevents pain-related responses in several models of neuropathic pain in rats or mice (e.g., spinal nerve ligation models, streptozocin-induced diabetes model, spinal cord injury model, acute herpes zoster infection model). Gabapentin also decreases pain-related responses after peripheral inflammation (carrageenan footpad test, late phase of formalin test). Gabapentin did not alter immediate pain-related behaviors (rat tail flick test, formalin footpad acute phase, acetic acid abdominal constriction test, footpad heat irradiation test). The mechanism by which gabapentin exerts its anticonvulsant action is unknown, but in animal test systems designed to detect anticonvulsant activity, gabapentin prevents seizures as do other marketed anticonvulsants. Gabapentin exhibits antiseizure activity in mice and rats in both the maximal electroshock and pentylenetetrazole seizure models and other preclinical models (e.g., strains with genetic epilepsy, etc.). Gabapentin is structurally related to the neurotransmitter GABA (gamma-aminobutyric acid) but it does not modify GABAA or GABAB radioligand binding, it is not converted metabolically into GABA or a GABA agonist, and it is not an inhibitor of GABA uptake or degradation. Gabapentin was tested in radioligand binding assays at concentrations up to 100 uM and did not exhibit affinity for a number of other common receptor sites, including benzodiazepine, glutamate, N-methyl-D-aspartate (NMDA), quisqualate, kainate, strychnine-insensitive or strychnine-sensitive glycine, alpha 1, alpha 2, or beta adrenergic, adenosine A1 or A2, cholinergic muscarinic or nicotinic, dopamine D1 or D2, histamine H1, serotonin S1 or S2, opiate mu, delta or kappa, cannabinoid 1, voltage-sensitive calcium channel sites labeled with nitrendipine or diltiazem, or at voltage-sensitive sodium channel sites labeled with batrachotoxinin A 20-alpha-benzoate. Furthermore, gabapentin did not alter the cellular uptake of dopamine, noradrenaline, or serotonin. In vitro studies with radiolabeled gabapentin have revealed a gabapentin binding site in areas of rat brain including neocortex and hippocampus. A high-affinity binding protein in animal brain tissue has been identified as an auxiliary subunit of voltage-activated calcium channels. Molecular weight: 171.24 Formula: C9H17NO2 CLOGP: -0.66 LIPINSKI: 0 HAC: 3 HDO: 2 TPSA: 63.32 ALOGS: -1.60 ROTB: 3 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

gabapentin
gabamox
gabapen
neurontin
gabapentine

The mechanism by which gabapentin exerts its analgesic action is unknown, but in animal models of analgesia, gabapentin prevents allodynia (pain-related behavior in response to a normally innocuous stimulus) and hyperalgesia (exaggerated response to painful stimuli). In particular, gabapentin prevents pain-related responses in several models of neuropathic pain in rats or mice (e.g., spinal nerve ligation models, streptozocin-induced diabetes model, spinal cord injury model, acute herpes zoster infection model). Gabapentin also decreases pain-related responses after peripheral inflammation (carrageenan footpad test, late phase of formalin test). Gabapentin did not alter immediate pain-related behaviors (rat tail flick test, formalin footpad acute phase, acetic acid abdominal constriction test, footpad heat irradiation test). The mechanism by which gabapentin exerts its anticonvulsant action is unknown, but in animal test systems designed to detect anticonvulsant activity, gabapentin prevents seizures as do other marketed anticonvulsants. Gabapentin exhibits antiseizure activity in mice and rats in both the maximal electroshock and pentylenetetrazole seizure models and other preclinical models (e.g., strains with genetic epilepsy, etc.). Gabapentin is structurally related to the neurotransmitter GABA (gamma-aminobutyric acid) but it does not modify GABAA or GABAB radioligand binding, it is not converted metabolically into GABA or a GABA agonist, and it is not an inhibitor of GABA uptake or degradation. Gabapentin was tested in radioligand binding assays at concentrations up to 100 uM and did not exhibit affinity for a number of other common receptor sites, including benzodiazepine, glutamate, N-methyl-D-aspartate (NMDA), quisqualate, kainate, strychnine-insensitive or strychnine-sensitive glycine, alpha 1, alpha 2, or beta adrenergic, adenosine A1 or A2, cholinergic muscarinic or nicotinic, dopamine D1 or D2, histamine H1, serotonin S1 or S2, opiate mu, delta or kappa, cannabinoid 1, voltage-sensitive calcium channel sites labeled with nitrendipine or diltiazem, or at voltage-sensitive sodium channel sites labeled with batrachotoxinin A 20-alpha-benzoate. Furthermore, gabapentin did not alter the cellular uptake of dopamine, noradrenaline, or serotonin. In vitro studies with radiolabeled gabapentin have revealed a gabapentin binding site in areas of rat brain including neocortex and hippocampus. A high-affinity binding protein in animal brain tissue has been identified as an auxiliary subunit of voltage-activated calcium channels.

Molecular weight: 171.24
Formula: C9H17NO2
CLOGP: -0.66
LIPINSKI: 0
HAC: 3
HDO: 2
TPSA: 63.32
ALOGS: -1.60
ROTB: 3

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
1.80	g	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	3	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	10 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	100 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	116.79 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	60 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	0.71 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	1.70 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.97 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	5.30 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Dec. 30, 1993	FDA	PFIZER PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug hypersensitivity	1707.99	9.78	4328	289448	239497	46152789
Drug ineffective for unapproved indication	1111.83	9.78	881	292895	15532	46376754
Completed suicide	526.61	9.78	2062	291714	143858	46248428
Multiple sclerosis relapse	375.02	9.78	823	292953	41302	46350984
Pemphigus	252.08	9.78	7	293769	45267	46347019
Rheumatoid arthritis	239.76	9.78	746	293030	239469	46152817
Somnolence	225.34	9.78	1721	292055	154800	46237486
Myoclonus	220.01	9.78	354	293422	13998	46378288
Toxicity to various agents	217.51	9.78	2161	291615	209605	46182681
Contraindicated product administered	202.87	9.78	126	293650	79821	46312465
Maternal exposure during pregnancy	198.75	9.78	211	293565	102338	46289948
Neuropathy peripheral	180.82	9.78	1083	292693	89810	46302476
Neuralgia	172.66	9.78	402	293374	20981	46371305
Fall	169.96	9.78	2961	290815	326136	46066150
Synovitis	168.23	9.78	87	293689	60988	46331298
Drug abuse	160.70	9.78	807	292969	62601	46329685
Febrile neutropenia	160.66	9.78	216	293560	94411	46297875
Balance disorder	150.91	9.78	803	292973	63718	46328568
Memory impairment	148.41	9.78	913	292863	76424	46315862
Accidental death	147.26	9.78	109	293667	1726	46390560
Exposure during pregnancy	146.24	9.78	287	293489	107925	46284361
Suicidal ideation	144.58	9.78	720	293056	55662	46336624
Systemic lupus erythematosus	140.37	9.78	122	293654	65058	46327228
Multiple sclerosis	138.45	9.78	406	293370	24385	46367901
Depression	137.62	9.78	1656	292120	168448	46223838
Feeling abnormal	125.18	9.78	1270	292506	123790	46268496
Tremor	121.87	9.78	1187	292589	114452	46277834
Hypoaesthesia	117.47	9.78	1204	292572	117665	46274621
General physical health deterioration	115.67	9.78	359	293417	115410	46276876
Hand deformity	113.31	9.78	38	293738	34536	46357750
Product complaint	112.86	9.78	241	293535	11860	46380426
Rheumatoid factor positive	107.54	9.78	5	293771	20456	46371830
Dizziness	107.02	9.78	2851	290925	337563	46054723
Pyrexia	104.64	9.78	1555	292221	347247	46045039
Glossodynia	100.55	9.78	79	293697	44294	46347992
Device expulsion	98.03	9.78	26	293750	27516	46364770
Anaemia	96.72	9.78	1086	292690	254693	46137593
Pericarditis	92.26	9.78	19	293757	23908	46368378
Muscle spasms	91.10	9.78	1179	292597	121934	46270352
Confusional state	90.45	9.78	1461	292315	158431	46233855
C-reactive protein abnormal	88.26	9.78	14	293762	21256	46371030
Interstitial lung disease	86.71	9.78	128	293648	53821	46338465
Drug withdrawal syndrome	85.89	9.78	371	293405	27013	46365273
Gait disturbance	85.04	9.78	1335	292441	143928	46248358
Hallucination	84.91	9.78	572	293204	49379	46342907
Vision blurred	84.82	9.78	820	292956	78888	46313398
Thrombocytopenia	84.71	9.78	459	293317	126122	46266164
Infusion related reaction	83.63	9.78	340	293436	100868	46291418
C-reactive protein increased	82.97	9.78	151	293625	58439	46333847
Withdrawal syndrome	82.81	9.78	277	293499	17857	46374429
Mental status changes	82.28	9.78	464	293312	37624	46354662
Respiratory arrest	81.88	9.78	425	293351	33391	46358895
Product dose omission issue	79.56	9.78	1496	292280	167024	46225262
Sedation	79.38	9.78	320	293456	22590	46369696
Joint swelling	77.89	9.78	669	293107	165404	46226882
Pain in extremity	76.77	9.78	2151	291625	256529	46135757
Hepatic function abnormal	72.20	9.78	66	293710	34355	46357931
Treatment failure	69.42	9.78	325	293451	92762	46299524
Cytomegalovirus infection	68.74	9.78	15	293761	18129	46374157
Cardiac failure	68.31	9.78	265	293511	79683	46312603
Paraesthesia	65.22	9.78	1070	292706	116367	46275919
Migraine	64.75	9.78	700	293076	69326	46322960
Multiple organ dysfunction syndrome	64.06	9.78	144	293632	51566	46340720
Pancytopenia	64.00	9.78	296	293480	84762	46307524
Trigeminal neuralgia	62.03	9.78	85	293691	2904	46389382
Neutropenia	61.41	9.78	590	293186	142614	46249672
Amnesia	58.78	9.78	456	293320	41175	46351111
Sopor	58.67	9.78	264	293512	19564	46372722
Coordination abnormal	57.98	9.78	176	293600	10773	46381513
Seizure	57.55	9.78	1091	292685	121963	46270323
Premature baby	57.47	9.78	21	293755	18091	46374195
Anxiety	57.30	9.78	1525	292251	180432	46211854
Foetal exposure during pregnancy	56.52	9.78	66	293710	30681	46361605
Pleural effusion	56.47	9.78	299	293477	82653	46309633
Unresponsive to stimuli	56.21	9.78	371	293405	31803	46360483
Drug dependence	55.93	9.78	261	293515	19640	46372646
Product use in unapproved indication	55.22	9.78	836	292940	89437	46302849
Dyskinesia	55.14	9.78	341	293435	28584	46363702
Red blood cell sedimentation rate abnormal	54.39	9.78	10	293766	13639	46378647
Atrial fibrillation	54.20	9.78	405	293371	103185	46289101
Burning sensation	53.86	9.78	470	293306	43941	46348345
Mucosal inflammation	53.81	9.78	102	293674	38874	46353412
Hypokalaemia	52.56	9.78	331	293445	87693	46304593
Leukopenia	52.50	9.78	236	293540	68107	46324179
Fibromyalgia	52.37	9.78	401	293375	36062	46356224
Hepatic enzyme increased	52.28	9.78	301	293475	81486	46310800
Muscular weakness	51.41	9.78	838	292938	91006	46301280
Malignant neoplasm progression	51.20	9.78	222	293554	64704	46327582
Bone marrow failure	51.06	9.78	67	293709	29602	46362684
Insomnia	49.85	9.78	1375	292401	163549	46228737
Hypersomnia	49.82	9.78	211	293565	15228	46377058
Lethargy	48.92	9.78	515	293261	50656	46341630
Hyponatraemia	48.46	9.78	406	293370	100926	46291360
Blood lactate dehydrogenase increased	48.36	9.78	35	293741	20465	46371821
Erythema	48.30	9.78	621	293155	142199	46250087
Mental disorder	46.99	9.78	271	293505	22154	46370132
Drug reaction with eosinophilia and systemic symptoms	46.60	9.78	71	293705	29477	46362809
Therapeutic response decreased	46.54	9.78	129	293647	43016	46349270
Feeling drunk	45.35	9.78	85	293691	3802	46388484
Arthropathy	45.33	9.78	329	293447	84371	46307915
Abortion spontaneous	44.52	9.78	134	293642	43512	46348774
Speech disorder	44.51	9.78	384	293392	35783	46356503
Sleep apnoea syndrome	44.39	9.78	265	293511	21936	46370350
Respiratory depression	43.40	9.78	166	293610	11434	46380852
Osteonecrosis of jaw	43.26	9.78	95	293681	34307	46357979
Drug resistance	43.17	9.78	28	293748	17340	46374946
Septic shock	42.63	9.78	203	293573	57690	46334596
Pleural thickening	42.52	9.78	66	293710	2529	46389757
Presbyacusis	42.42	9.78	69	293707	2753	46389533
Live birth	42.41	9.78	7	293769	10323	46381963
Myocardial stunning	42.01	9.78	21	293755	154	46392132
Muscle twitching	41.66	9.78	193	293583	14479	46377807
Hepatotoxicity	41.50	9.78	58	293718	24951	46367335
Inadequate analgesia	41.03	9.78	68	293708	2756	46389530
Premature delivery	40.97	9.78	47	293729	22022	46370264
Cardio-respiratory arrest	40.78	9.78	565	293211	59304	46332982
Restless legs syndrome	40.36	9.78	202	293574	15641	46376645
Pleural fibrosis	40.34	9.78	77	293699	3492	46388794
Intentional product misuse	40.31	9.78	464	293312	46664	46345622
Crying	40.14	9.78	249	293527	20892	46371394
Anaphylactic shock	40.05	9.78	41	293735	20233	46372053
Duodenal ulcer perforation	39.13	9.78	4	293772	8498	46383788
Cognitive disorder	38.50	9.78	378	293398	36505	46355781
Full blood count decreased	38.12	9.78	255	293521	21956	46370330
Therapeutic response unexpected	37.61	9.78	196	293580	15420	46376866
Blood magnesium increased	37.59	9.78	68	293708	2959	46389327
Euphoric mood	37.46	9.78	83	293693	4189	46388097
Pneumocystis jirovecii pneumonia	37.33	9.78	25	293751	15223	46377063
Head injury	36.54	9.78	273	293503	24363	46367923
Bradycardia	36.21	9.78	256	293520	66042	46326244
Premature labour	36.02	9.78	13	293763	11286	46381000
Hepatocellular injury	35.92	9.78	83	293693	29439	46362847
Impaired driving ability	35.84	9.78	81	293695	4143	46388143
Abdominal discomfort	34.54	9.78	707	293069	150458	46241828
Peritonitis	34.41	9.78	48	293728	20666	46371620
Influenza like illness	34.36	9.78	531	293245	57039	46335247
Ascites	34.04	9.78	117	293659	36467	46355819
Eosinophilic colitis	34.00	9.78	16	293760	101	46392185
Melaena	33.85	9.78	78	293698	27694	46364592
Alopecia	33.54	9.78	772	293004	161642	46230644
Bone erosion	33.44	9.78	9	293767	9434	46382852
Diplopia	33.43	9.78	223	293553	19182	46373104
Dry mouth	33.31	9.78	508	293268	54418	46337868
Hepatic failure	33.08	9.78	104	293672	33312	46358974
Off label use	32.93	9.78	2006	291770	377835	46014451
Pain	32.91	9.78	3454	290322	473494	45918792
Hypermobility syndrome	32.74	9.78	30	293746	649	46391637
Rash maculo-papular	32.61	9.78	80	293696	27794	46364492
Stiff person syndrome	32.46	9.78	18	293758	167	46392119
Cough	32.20	9.78	1155	292621	229094	46163192
Febrile bone marrow aplasia	32.18	9.78	3	293773	6859	46385427
Hyperaesthesia	31.53	9.78	115	293661	7741	46384545
Jaundice	31.29	9.78	86	293690	28759	46363527
Ataxia	30.94	9.78	171	293605	13759	46378527
Neck pain	30.70	9.78	504	293272	54802	46337484
Epigastric discomfort	30.69	9.78	92	293684	5592	46386694
Mood altered	30.46	9.78	162	293614	12845	46379441
Helicobacter infection	30.45	9.78	18	293758	11718	46380568
Diabetic neuropathy	30.32	9.78	71	293705	3718	46388568
Pregnancy	30.12	9.78	80	293696	27057	46365229
Hallucination, visual	29.96	9.78	204	293572	17669	46374617
Accidental poisoning	29.70	9.78	27	293749	578	46391708
Nerve injury	29.43	9.78	111	293665	7594	46384692
Deafness neurosensory	29.42	9.78	78	293698	4416	46387870
Nervousness	29.32	9.78	291	293485	28184	46364102
Thrombotic microangiopathy	29.25	9.78	8	293768	8298	46383988
Epistaxis	29.23	9.78	261	293515	64044	46328242
Urinary incontinence	29.10	9.78	291	293485	28239	46364047
Somatic symptom disorder	29.08	9.78	47	293729	1865	46390421
Rash	28.61	9.78	1896	291880	354616	46037670
Gastrointestinal haemorrhage	28.58	9.78	330	293446	77043	46315243
Intervertebral disc protrusion	28.52	9.78	223	293553	20182	46372104
Back pain	27.96	9.78	1602	292174	208437	46183849
Rheumatoid nodule	27.71	9.78	11	293765	9009	46383277
Toxic epidermal necrolysis	27.62	9.78	62	293714	22216	46370070
Spinal operation	27.43	9.78	87	293689	5453	46386833
Congenital thrombocytopenia	27.40	9.78	11	293765	44	46392242
Anger	27.34	9.78	147	293629	11705	46380581
Gestational diabetes	27.28	9.78	6	293770	7213	46385073
Back disorder	27.26	9.78	122	293654	9019	46383267
Gait inability	26.79	9.78	339	293437	34864	46357422
Fatigue	26.57	9.78	4287	289489	604410	45787876
Cyst	26.52	9.78	148	293628	11952	46380334
Myelodysplastic syndrome	26.50	9.78	36	293740	15675	46376611
Agranulocytosis	26.49	9.78	63	293713	22122	46370164
Acute respiratory distress syndrome	26.37	9.78	62	293714	21860	46370426
Limb discomfort	26.05	9.78	238	293538	22538	46369748
Concussion	26.02	9.78	100	293676	6903	46385383
Somatic delusion	25.58	9.78	25	293751	588	46391698
Hypersensitivity	25.56	9.78	735	293041	149586	46242700
Human epidermal growth factor receptor decreased	25.34	9.78	8	293768	12	46392274
Incoherent	25.28	9.78	74	293702	4438	46387848
Tachycardia	25.17	9.78	458	293318	99164	46293122
Complex regional pain syndrome	25.13	9.78	46	293730	2020	46390266
Drug-induced liver injury	25.07	9.78	79	293697	25289	46366997
Lower respiratory tract infection	24.86	9.78	224	293552	54865	46337421
Paranoia	24.83	9.78	132	293644	10465	46381821
Cerebral infarction	24.36	9.78	71	293705	23295	46368991
Haemophagocytic lymphohistiocytosis	24.31	9.78	11	293765	8331	46383955
Asterixis	24.04	9.78	34	293742	1197	46391089
Drug screen positive	23.93	9.78	66	293710	3825	46388461
Liver injury	23.77	9.78	40	293736	15961	46376325
Focal dyscognitive seizures	23.74	9.78	54	293722	2774	46389512
Haemoglobin decreased	23.60	9.78	624	293152	128325	46263961
Alanine aminotransferase increased	23.50	9.78	403	293373	88048	46304238
Psychotic disorder due to a general medical condition	23.36	9.78	15	293761	186	46392100
Intervertebral disc degeneration	23.26	9.78	153	293623	13099	46379187
Transplant rejection	23.14	9.78	16	293760	9580	46382706
Transaminases increased	23.07	9.78	93	293683	27668	46364618
Ankle fracture	23.06	9.78	172	293604	15339	46376947
Therapeutic product effect decreased	23.04	9.78	373	293403	82228	46310058
Poisoning	23.02	9.78	159	293617	13835	46378451
Cerebral haemorrhage	22.98	9.78	96	293680	28275	46364011
Dyspnoea	22.82	9.78	2869	290907	512679	45879607
Blood bilirubin increased	22.82	9.78	124	293652	34060	46358226
Urinary tract infection	22.75	9.78	1644	292132	218622	46173664
Central nervous system lesion	22.69	9.78	120	293656	9495	46382791
Mental impairment	22.59	9.78	145	293631	12311	46379975
Pre-eclampsia	22.58	9.78	11	293765	7983	46384303
Visual impairment	22.42	9.78	564	293212	66125	46326161
Dysarthria	22.42	9.78	346	293430	37152	46355134
Anorgasmia	22.40	9.78	23	293753	575	46391711
Sacroiliitis	22.34	9.78	45	293731	2124	46390162
Drug titration error	22.27	9.78	23	293753	579	46391707
Neutropenic sepsis	22.07	9.78	27	293749	12297	46379989
Hyperreflexia	22.02	9.78	78	293698	5176	46387110
Eosinophilia	21.82	9.78	56	293720	19161	46373125
Limb injury	21.74	9.78	200	293576	18974	46373312
Bone cyst	21.66	9.78	43	293733	2008	46390278
Acute kidney injury	21.57	9.78	1239	292537	234616	46157670
Nightmare	21.35	9.78	178	293598	16420	46375866
Acute myeloid leukaemia	21.16	9.78	42	293734	15736	46376550
Device difficult to use	21.16	9.78	12	293764	7992	46384294
Overdose	21.11	9.78	813	292963	101166	46291120
Lactic acidosis	21.02	9.78	126	293650	33783	46358503
Haemorrhage	20.66	9.78	233	293543	54636	46337650
Accidental exposure to product	20.59	9.78	66	293710	21015	46371271
Dysstasia	20.39	9.78	185	293591	17483	46374803
Disseminated intravascular coagulation	20.36	9.78	57	293719	18948	46373338
Substance abuse	20.23	9.78	65	293711	4102	46388184
Abdominal pain	20.21	9.78	1213	292563	228818	46163468
Drug diversion	20.20	9.78	26	293750	835	46391451
Vertigo	20.19	9.78	449	293327	51599	46340687
Foetal growth restriction	20.19	9.78	8	293768	6559	46385727
Thinking abnormal	20.17	9.78	118	293658	9696	46382590
Red blood cell sedimentation rate increased	20.10	9.78	75	293701	22814	46369472
Tuberculosis	20.00	9.78	21	293755	10244	46382042
Abortion induced	19.98	9.78	21	293755	10239	46382047
Cholestasis	19.97	9.78	94	293682	26799	46365487
Device use error	19.66	9.78	4	293772	5077	46387209
Pre-existing condition improved	19.53	9.78	88	293688	6524	46385762
Haematoma	19.45	9.78	119	293657	31753	46360533
Device dislocation	19.43	9.78	71	293705	21731	46370555
Bronchiectasis	19.37	9.78	18	293758	9298	46382988
Torsade de pointes	19.36	9.78	29	293747	12125	46380161
Cardiogenic shock	19.18	9.78	47	293729	16337	46375949
Therapy non-responder	19.15	9.78	166	293610	40986	46351300
Caesarean section	19.15	9.78	48	293728	16555	46375731
Gamma-glutamyltransferase increased	19.12	9.78	119	293657	31621	46360665
Autonomic nervous system imbalance	18.91	9.78	45	293731	2381	46389905
Unintentional medical device removal	18.88	9.78	3	293773	4550	46387736
Posterior reversible encephalopathy syndrome	18.88	9.78	42	293734	15099	46377187
Irritability	18.83	9.78	271	293505	28675	46363611
Hepatitis	18.78	9.78	122	293654	32093	46360193
Serotonin syndrome	18.75	9.78	234	293542	23986	46368300
Ventricular fibrillation	18.73	9.78	27	293749	11469	46380817
Dysphemia	18.67	9.78	44	293732	2314	46389972
Joint injury	18.67	9.78	194	293582	19015	46373271
Metastases to liver	18.65	9.78	62	293714	19523	46372763
Pulmonary aplasia	18.63	9.78	6	293770	10	46392276
Hypotension	18.44	9.78	1238	292538	231351	46160935
Peroneal nerve palsy	18.44	9.78	63	293713	4105	46388181
Allodynia	18.40	9.78	20	293756	535	46391751
Colitis ulcerative	18.40	9.78	54	293722	17678	46374608
Drug effective for unapproved indication	18.34	9.78	34	293742	1508	46390778
Brain injury	18.28	9.78	82	293694	6068	46386218
Post herpetic neuralgia	18.23	9.78	39	293737	1921	46390365
Acute hepatic failure	18.22	9.78	41	293735	14680	46377606
Wrong patient received product	17.84	9.78	36	293740	1701	46390585
Neutrophil count decreased	17.72	9.78	181	293595	43245	46349041
Vomiting	17.59	9.78	2540	291236	450254	45942032
Shock haemorrhagic	17.54	9.78	17	293759	8607	46383679
Pituitary tumour benign	17.46	9.78	35	293741	1646	46390640
Hyperhidrosis	17.32	9.78	707	293069	88601	46303685
Face oedema	17.32	9.78	62	293714	19091	46373195
Myoclonic epilepsy	17.30	9.78	25	293751	898	46391388
Body height decreased	17.28	9.78	112	293664	9540	46382746
Graft versus host disease	17.24	9.78	10	293766	6578	46385708
Secondary progressive multiple sclerosis	17.22	9.78	29	293747	1191	46391095
Progressive multiple sclerosis	17.16	9.78	23	293753	769	46391517
Genital haemorrhage	17.13	9.78	10	293766	6556	46385730
Nerve compression	17.09	9.78	87	293689	6781	46385505
Myelosuppression	17.09	9.78	14	293762	7689	46384597
Circulatory collapse	17.00	9.78	74	293702	21550	46370736
Muscle tightness	16.90	9.78	117	293659	10188	46382098
Liver function test abnormal	16.88	9.78	199	293577	46288	46345998
Discomfort	16.86	9.78	200	293576	46470	46345816
Bone density decreased	16.80	9.78	22	293754	9730	46382556
Colitis	16.79	9.78	152	293624	37195	46355091
Prescription drug used without a prescription	16.78	9.78	31	293745	1371	46390915
Stillbirth	16.78	9.78	10	293766	6481	46385805
Surgery	16.60	9.78	264	293512	28521	46363765
Toxic skin eruption	16.59	9.78	33	293743	12354	46379932
Liver disorder	16.56	9.78	152	293624	37094	46355192
Hyperbilirubinaemia	16.54	9.78	25	293751	10413	46381873
Pharyngitis	16.51	9.78	56	293720	17527	46374759
Femur fracture	16.45	9.78	151	293625	36846	46355440
Drug use disorder	16.44	9.78	46	293730	2689	46389597
Cytomegalovirus viraemia	16.37	9.78	4	293772	4474	46387812
Tardive dyskinesia	16.35	9.78	92	293684	7451	46384835
Asthma	16.21	9.78	445	293331	91097	46301189
Injection site mass	16.11	9.78	155	293621	14885	46377401
Atonic urinary bladder	16.09	9.78	9	293767	85	46392201
Obstructive airways disorder	16.08	9.78	38	293738	13374	46378912
Cardiac arrest	16.03	9.78	709	293067	89690	46302596
Metabolic encephalopathy	16.03	9.78	72	293704	5331	46386955
Panniculitis	15.89	9.78	8	293768	5696	46386590
Bipolar disorder	15.87	9.78	88	293688	7089	46385197
Angioedema	15.63	9.78	165	293611	39177	46353109
Sensory loss	15.51	9.78	85	293691	6817	46385469
Palmar-plantar erythrodysaesthesia syndrome	15.47	9.78	71	293705	20380	46371906
Epstein-Barr virus infection	15.46	9.78	12	293764	6772	46385514
Aspartate aminotransferase increased	15.42	9.78	377	293399	78323	46313963
Hypokinesia	15.42	9.78	123	293653	11199	46381087
Proteinuria	15.36	9.78	53	293723	16500	46375786
Lupus-like syndrome	15.34	9.78	16	293760	7828	46384458
Head banging	15.33	9.78	16	293760	408	46391878
Suspected suicide	15.27	9.78	64	293712	4597	46387689
Therapy cessation	15.27	9.78	244	293532	26385	46365901
Pericardial effusion	15.26	9.78	96	293680	25447	46366839
Economic problem	15.25	9.78	37	293739	1983	46390303
Uterine perforation	15.16	9.78	14	293762	7253	46385033
Exposure via ingestion	14.98	9.78	52	293724	3415	46388871
Urticaria	14.98	9.78	598	293178	117294	46274992
Ejection fraction decreased	14.96	9.78	60	293716	17877	46374409
Rash erythematous	14.92	9.78	141	293635	34209	46358077
Hostility	14.92	9.78	29	293747	1333	46390953
Postmortem blood drug level abnormal	14.87	9.78	14	293762	314	46391972
Exostosis	14.81	9.78	113	293663	10150	46382136
Skin reaction	14.80	9.78	29	293747	10917	46381369
Disturbance in attention	14.79	9.78	280	293496	31280	46361006
Oligohydramnios	14.72	9.78	8	293768	5457	46386829
Ventricular tachycardia	14.63	9.78	56	293720	16911	46375375
Facial pain	14.59	9.78	90	293686	7535	46384751
Low birth weight baby	14.57	9.78	8	293768	5426	46386860
Pulmonary fibrosis	14.47	9.78	71	293705	20021	46372265
Hypercholesterolaemia	14.36	9.78	32	293744	11498	46380788
Acute myocardial infarction	14.32	9.78	130	293646	31794	46360492
Tooth loss	14.21	9.78	81	293695	6592	46385694
Jaundice cholestatic	14.09	9.78	7	293769	5022	46387264
Myotonia	14.08	9.78	10	293766	148	46392138
Disorganised speech	14.06	9.78	22	293754	849	46391437
Deprescribing error	14.05	9.78	6	293770	29	46392257
Agitation	14.00	9.78	452	293324	54963	46337323
Blood lactic acid	13.99	9.78	9	293767	112	46392174
Contusion	13.97	9.78	679	293097	86808	46305478
Tubulointerstitial nephritis	13.96	9.78	47	293729	14741	46377545
Carpal tunnel syndrome	13.94	9.78	157	293619	15702	46376584
Tumour lysis syndrome	13.88	9.78	15	293761	7221	46385065
Bronchopulmonary aspergillosis	13.87	9.78	16	293760	7480	46384806
Acute coronary syndrome	13.82	9.78	27	293749	10177	46382109
Mucocutaneous haemorrhage	13.82	9.78	7	293769	53	46392233
Hepatitis cholestatic	13.77	9.78	13	293763	6664	46385622
Osteosclerosis	13.72	9.78	51	293725	3465	46388821
Metabolic acidosis	13.70	9.78	167	293609	38613	46353673
Complication of device insertion	13.67	9.78	7	293769	4937	46387349
Pulmonary embolism	13.54	9.78	552	293224	108033	46284253
Congenital absence of vertebra	13.54	9.78	5	293771	15	46392271
Coma	13.48	9.78	471	293305	57878	46334408
Pancreatitis chronic	13.46	9.78	33	293743	1780	46390506
Haemolysis	13.46	9.78	11	293765	6048	46386238
No adverse event	13.42	9.78	144	293632	34087	46358199
Breakthrough pain	13.20	9.78	25	293751	1127	46391159
Atrioventricular block	13.20	9.78	14	293762	6797	46385489
Arthralgia	13.15	9.78	2054	291722	362549	46029737
Internal hernia	13.14	9.78	6	293770	35	46392251
Blood pressure increased	13.13	9.78	657	293119	126009	46266277
Cervical spinal stenosis	13.09	9.78	34	293742	1901	46390385
Glycosylated haemoglobin decreased	13.07	9.78	16	293760	488	46391798
Wound	13.05	9.78	190	293586	42612	46349674
Foot fracture	13.00	9.78	184	293592	19398	46372888
Forced expiratory volume decreased	13.00	9.78	8	293768	5096	46387190
Gastroenteritis	12.98	9.78	94	293682	24125	46368161
Postmortem blood drug level increased	12.98	9.78	15	293761	430	46391856
Hypocalcaemia	12.93	9.78	107	293669	26678	46365608
Unintended pregnancy	12.92	9.78	10	293766	5650	46386636
Blood creatine phosphokinase increased	12.83	9.78	112	293664	27612	46364674
Enterocolitis	12.73	9.78	12	293764	6156	46386130
Movement disorder	12.71	9.78	162	293614	16687	46375599
Sinusitis	12.71	9.78	677	293099	129091	46263195
Eyelid oedema	12.69	9.78	29	293747	10328	46381958
Peripheral nerve operation	12.67	9.78	4	293772	6	46392280
Cervicogenic headache	12.67	9.78	4	293772	6	46392280
Haematotoxicity	12.61	9.78	15	293761	6918	46385368
Phobia	12.50	9.78	13	293763	330	46391956
Road traffic accident	12.45	9.78	214	293562	23477	46368809
Lymphoma	12.42	9.78	27	293749	9786	46382500
Skin necrosis	12.33	9.78	22	293754	8582	46383704
Arrhythmia	12.32	9.78	150	293626	34691	46357595
Adverse drug reaction	12.31	9.78	366	293410	43996	46348290
Heteroplasia	12.30	9.78	4	293772	7	46392279
Turbinectomy	12.22	9.78	3	293773	0	46392286
Muscle relaxant drug level above therapeutic	12.22	9.78	3	293773	0	46392286
Premature ageing	12.22	9.78	3	293773	0	46392286
CSF neutrophil count increased	12.22	9.78	3	293773	0	46392286
Bradyphrenia	12.22	9.78	74	293702	6156	46386130
Schizophrenia	12.20	9.78	22	293754	8546	46383740
Dysgraphia	12.18	9.78	42	293734	2750	46389536
Injection site atrophy	12.12	9.78	16	293760	527	46391759
Somnambulism	11.98	9.78	63	293713	4974	46387312
Infection	11.97	9.78	703	293073	132889	46259397
Lymphoedema	11.97	9.78	94	293682	8518	46383768
Asthenia	11.96	9.78	2177	291599	308898	46083388
Narcolepsy	11.88	9.78	24	293752	1135	46391151
Drug abuser	11.88	9.78	46	293730	3187	46389099
Altered state of consciousness	11.86	9.78	92	293684	23256	46369030
Weight increased	11.83	9.78	1195	292581	163278	46229008
Acute generalised exanthematous pustulosis	11.80	9.78	26	293750	9379	46382907
Withdrawal catatonia	11.78	9.78	6	293770	46	46392240
Spinal cord injury	11.78	9.78	16	293760	542	46391744
Depressed level of consciousness	11.75	9.78	387	293389	47182	46345104
Lung adenocarcinoma stage I	11.74	9.78	5	293771	24	46392262
Arteriovenous malformation	11.73	9.78	25	293751	1228	46391058
Pollakiuria	11.63	9.78	216	293560	24045	46368241
Peritonitis bacterial	11.63	9.78	23	293753	8630	46383656
Cholecystitis chronic	11.61	9.78	31	293745	10468	46381818
Shock	11.61	9.78	85	293691	21760	46370526
Food allergy	11.58	9.78	16	293760	6917	46385369
Burns second degree	11.53	9.78	18	293758	693	46391593
Soft tissue disorder	11.47	9.78	6	293770	4180	46388106
Copper deficiency	11.46	9.78	6	293770	49	46392237
Concomitant disease aggravated	11.44	9.78	20	293756	7862	46384424
Empty sella syndrome	11.41	9.78	5	293771	26	46392260
Haemangioma of skin	11.40	9.78	12	293764	309	46391977
Laryngeal oedema	11.39	9.78	10	293766	5309	46386977
Upper airway resistance syndrome	11.35	9.78	4	293772	10	46392276
Ankylosing spondylitis	11.35	9.78	77	293699	6660	46385626
Septic encephalopathy	11.31	9.78	7	293769	81	46392205
JC polyomavirus test positive	11.25	9.78	21	293755	936	46391350
Disease progression	11.19	9.78	465	293311	90835	46301451
Complication of device removal	11.15	9.78	4	293772	3486	46388800
Electroencephalogram abnormal	11.12	9.78	50	293726	3704	46388582
Brain malformation	11.11	9.78	5	293771	28	46392258
Porphyria	11.06	9.78	8	293768	122	46392164
Hypomagnesaemia	11.06	9.78	88	293688	22122	46370164
Panic attack	11.06	9.78	184	293592	20058	46372228
Toe operation	11.05	9.78	16	293760	576	46391710
Hypertension	10.96	9.78	1075	292701	195281	46197005
Pneumonitis	10.96	9.78	120	293656	28300	46363986
Disorientation	10.90	9.78	307	293469	36611	46355675
Myocarditis	10.90	9.78	20	293756	7719	46384567
Hepatitis acute	10.90	9.78	22	293754	8192	46384094
Connective tissue inflammation	10.88	9.78	6	293770	55	46392231
Acne	10.83	9.78	77	293699	19842	46372444
Confusional arousal	10.82	9.78	7	293769	88	46392198
Lymphadenopathy	10.79	9.78	147	293629	33341	46358945
Metastases to lung	10.79	9.78	33	293743	10663	46381623
Tachypnoea	10.75	9.78	50	293726	14301	46377985
Uveitis	10.75	9.78	24	293752	8617	46383669
Walking aid user	10.71	9.78	59	293717	4741	46387545
Femoral artery dissection	10.70	9.78	5	293771	31	46392255
Hepatitis fulminant	10.70	9.78	4	293772	3398	46388888
Laryngeal dyspnoea	10.69	9.78	8	293768	129	46392157
Pseudomonas infection	10.65	9.78	29	293747	9729	46382557
Pulmonary arterial hypertension	10.60	9.78	108	293668	25820	46366466
Muscle injury	10.60	9.78	9	293767	4857	46387429
Gastrointestinal inflammation	10.60	9.78	7	293769	4294	46387992
Inflammation	10.58	9.78	230	293546	48551	46343735
Dermatitis bullous	10.55	9.78	20	293756	7623	46384663
Plasma cell myeloma	10.52	9.78	360	293416	44118	46348168
Lip oedema	10.50	9.78	4	293772	3360	46388926
Upper gastrointestinal haemorrhage	10.47	9.78	62	293714	16676	46375610
Infective pulmonary exacerbation of cystic fibrosis	10.44	9.78	34	293742	10773	46381513
Ischaemic stroke	10.43	9.78	62	293714	16660	46375626
Hypoxic-ischaemic encephalopathy	10.42	9.78	52	293724	4021	46388265
Right ventricular failure	10.40	9.78	59	293717	16034	46376252
Toxicologic test abnormal	10.38	9.78	17	293759	682	46391604
Gastric bypass	10.37	9.78	25	293751	1334	46390952
Skin toxicity	10.37	9.78	5	293771	3649	46388637
Osteopenia	10.33	9.78	157	293619	16804	46375482
Radiculopathy	10.28	9.78	60	293716	4925	46387361
Metastases to bone	10.28	9.78	66	293710	17410	46374876
Bladder disorder	10.25	9.78	78	293698	7000	46385286
Stress cardiomyopathy	10.20	9.78	21	293755	7763	46384523
International normalised ratio increased	10.19	9.78	221	293555	46662	46345624
Naevus haemorrhage	10.18	9.78	7	293769	98	46392188
Subarachnoid haemorrhage	10.15	9.78	36	293740	11117	46381169
Micturition urgency	10.14	9.78	84	293692	7733	46384553
Malignant polyp	10.12	9.78	9	293767	187	46392099
Pathogen resistance	10.11	9.78	14	293762	6046	46386240
Accidental overdose	10.09	9.78	180	293596	19886	46372400
Sciatica	10.06	9.78	172	293604	18848	46373438
Dry eye	10.06	9.78	256	293520	30066	46362220
Drug screen false positive	10.01	9.78	19	293757	858	46391428
Substance use	9.99	9.78	13	293763	422	46391864
Blood potassium increased	9.93	9.78	156	293620	16811	46375475
Bronchospasm	9.92	9.78	58	293718	15649	46376637
Pruritus	9.90	9.78	1355	292421	240997	46151289
Parapsoriasis	9.89	9.78	7	293769	103	46392183
Normal newborn	9.87	9.78	14	293762	5987	46386299
Osteoporosis	9.84	9.78	188	293588	40420	46351866
Cystitis haemorrhagic	9.84	9.78	5	293771	3542	46388744
Pulmonary toxicity	9.84	9.78	9	293767	4684	46387602
Sudden death	9.82	9.78	29	293747	9475	46382811

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug hypersensitivity	988.10	10.22	1509	159969	67010	29723990
Drug ineffective for unapproved indication	536.26	10.22	455	161023	10425	29780575
Completed suicide	312.99	10.22	1211	160267	98281	29692719
Myoclonus	224.37	10.22	316	161162	12996	29778004
Neuropathy peripheral	168.02	10.22	789	160689	69686	29721314
Somnolence	157.08	10.22	975	160503	95788	29695212
Toxicity to various agents	139.03	10.22	1513	159965	175670	29615330
Drug withdrawal syndrome	138.11	10.22	320	161158	19489	29771511
Interstitial lung disease	132.69	10.22	80	161398	60117	29730883
Pain	125.77	10.22	1453	160025	171188	29619812
Fall	125.14	10.22	1514	159964	180358	29610642
Multiple sclerosis relapse	111.74	10.22	206	161272	10656	29780344
Sedation	104.94	10.22	256	161222	16117	29774883
Mental status changes	101.75	10.22	433	161045	36646	29754354
Neuralgia	100.83	10.22	193	161285	10273	29780727
Febrile neutropenia	93.89	10.22	280	161198	106413	29684587
Memory impairment	90.57	10.22	419	161059	36755	29754245
Hypoaesthesia	87.61	10.22	546	160932	53684	29737316
Cytomegalovirus infection	87.30	10.22	12	161466	23662	29767338
Confusional state	84.29	10.22	1103	160375	133731	29657269
Tremor	84.12	10.22	694	160784	74669	29716331
Hepatic function abnormal	82.70	10.22	63	161415	41882	29749118
Pain in extremity	80.70	10.22	929	160549	109292	29681708
Depression	80.57	10.22	793	160685	89644	29701356
Cardiac failure	78.46	10.22	212	161266	83206	29707794
Drug dependence	78.37	10.22	273	161205	21022	29769978
Anaemia	78.04	10.22	731	160747	207261	29583739
Withdrawal syndrome	76.50	10.22	180	161298	11070	29779930
Multiple organ dysfunction syndrome	76.35	10.22	141	161337	63346	29727654
Gait disturbance	75.26	10.22	673	160805	74104	29716896
Drug abuse	74.74	10.22	723	160755	81349	29709651
Insomnia	73.92	10.22	799	160679	92537	29698463
Suicidal ideation	70.27	10.22	382	161096	35732	29755268
Pyrexia	68.36	10.22	1147	160331	293342	29497658
Thrombocytopenia	65.97	10.22	450	161028	136594	29654406
Euphoric mood	65.21	10.22	97	161381	4193	29786807
Balance disorder	65.03	10.22	377	161101	36116	29754884
Product complaint	63.38	10.22	113	161365	5693	29785307
Renal impairment	63.01	10.22	237	161241	83947	29707053
Accidental death	62.24	10.22	66	161412	2013	29788987
Drug resistance	61.93	10.22	16	161462	20117	29770883
Muscle spasms	61.90	10.22	577	160901	64261	29726739
Respiratory arrest	58.62	10.22	312	161166	28946	29762054
Obsessive-compulsive disorder	57.81	10.22	90	161388	4051	29786949
General physical health deterioration	52.75	10.22	319	161159	99625	29691375
C-reactive protein increased	50.98	10.22	98	161380	43375	29747625
Burning sensation	48.79	10.22	197	161281	16277	29774723
Feeling abnormal	48.72	10.22	494	160984	56262	29734738
Anxiety	48.70	10.22	717	160761	89154	29701846
Disseminated intravascular coagulation	48.08	10.22	30	161448	22141	29768859
Neutropenia	47.58	10.22	453	161025	128087	29662913
Alanine aminotransferase increased	47.58	10.22	222	161256	74054	29716946
Amnesia	45.78	10.22	255	161223	24066	29766934
Dizziness	45.06	10.22	1372	160106	193537	29597463
Back disorder	44.17	10.22	99	161379	5895	29785105
Bone marrow failure	43.55	10.22	58	161420	29727	29761273
Septic shock	43.21	10.22	186	161292	63421	29727579
Therapeutic product effect variable	43.19	10.22	45	161433	1344	29789656
Paraesthesia	42.47	10.22	464	161014	53863	29737137
Vision blurred	42.36	10.22	377	161101	41439	29749561
Mucosal inflammation	41.97	10.22	62	161416	30432	29760568
Multiple sclerosis	41.73	10.22	109	161369	7158	29783842
Prescription drug used without a prescription	39.45	10.22	41	161437	1221	29789779
Inadequate analgesia	39.41	10.22	60	161418	2648	29788352
Congenital multiplex arthrogryposis	39.29	10.22	13	161465	31	29790969
Dyspnoea	38.22	10.22	1441	160037	331854	29459146
Overdose	38.18	10.22	653	160825	83684	29707316
Hepatic failure	37.97	10.22	79	161399	33964	29757036
Drug reaction with eosinophilia and systemic symptoms	37.22	10.22	60	161418	28428	29762572
Dysarthria	36.27	10.22	285	161193	30205	29760795
Disinhibition	35.28	10.22	48	161430	1909	29789091
Muscle spasticity	35.26	10.22	83	161395	5105	29785895
Myokymia	35.15	10.22	14	161464	66	29790934
Parasomnia	34.85	10.22	21	161457	273	29790727
Hypokalaemia	33.94	10.22	147	161331	50045	29740955
Haemophagocytic lymphohistiocytosis	33.75	10.22	6	161472	9785	29781215
Diabetic neuropathy	33.31	10.22	69	161409	3890	29787110
Jaundice	33.27	10.22	79	161399	32407	29758593
Full blood count decreased	33.13	10.22	170	161308	15547	29775453
Drug tolerance	33.03	10.22	49	161429	2113	29788887
Renal failure	32.91	10.22	493	160985	128473	29662527
Cerebral haemorrhage	32.87	10.22	81	161397	32806	29758194
Back pain	32.85	10.22	754	160724	101842	29689158
Hallucination	32.55	10.22	406	161072	48653	29742347
Nightmare	32.31	10.22	140	161338	11936	29779064
Blood bilirubin increased	32.28	10.22	96	161382	36540	29754460
Antipsychotic drug level below therapeutic	31.59	10.22	38	161440	1334	29789666
Malignant neoplasm progression	31.53	10.22	244	161234	72043	29718957
Atrial fibrillation	31.27	10.22	403	161075	107721	29683279
Anorgasmia	30.86	10.22	26	161452	589	29790411
Melaena	30.80	10.22	82	161396	32355	29758645
Hyperreflexia	30.66	10.22	55	161423	2784	29788216
Muscle twitching	30.39	10.22	105	161373	8050	29782950
Sciatica	30.18	10.22	77	161401	4984	29786016
Peripheral swelling	29.89	10.22	479	160999	60595	29730405
Acute kidney injury	29.80	10.22	1191	160287	272651	29518349
Sweat gland disorder	29.36	10.22	14	161464	109	29790891
Product dose omission issue	29.20	10.22	673	160805	90958	29700042
Peritonitis	28.89	10.22	44	161434	21331	29769669
Nerve injury	28.72	10.22	55	161423	2928	29788072
Infusion related reaction	28.54	10.22	117	161361	40447	29750553
Trigeminal neuralgia	28.03	10.22	29	161449	859	29790141
Off label use	27.81	10.22	1081	160397	248209	29542791
Aspartate aminotransferase increased	27.69	10.22	214	161264	63208	29727792
Asterixis	27.57	10.22	34	161444	1225	29789775
Bronchopulmonary aspergillosis	27.51	10.22	16	161462	12268	29778732
Tooth disorder	27.48	10.22	110	161368	9051	29781949
Fatigue	27.28	10.22	2043	159435	318630	29472370
Increased appetite	27.04	10.22	79	161399	5538	29785462
Ascites	26.94	10.22	101	161377	35820	29755180
Contraindicated product administered	26.80	10.22	32	161446	17199	29773801
Foetal exposure during pregnancy	26.79	10.22	105	161373	36766	29754234
Neutrophil count decreased	26.52	10.22	128	161350	42326	29748674
Aspergillus infection	26.35	10.22	11	161467	10203	29780797
Adverse drug reaction	26.24	10.22	214	161264	22931	29768069
Graft versus host disease	26.08	10.22	11	161467	10139	29780861
Delirium tremens	25.80	10.22	22	161456	507	29790493
Bradyphrenia	25.49	10.22	62	161416	3895	29787105
Spinal operation	25.47	10.22	45	161433	2251	29788749
Pneumocystis jirovecii pneumonia	25.37	10.22	33	161445	17087	29773913
Nervousness	25.19	10.22	128	161350	11660	29779340
Proteinuria	25.10	10.22	30	161448	16115	29774885
Cholestasis	24.51	10.22	62	161416	24888	29766112
Bradypnoea	24.41	10.22	40	161438	1881	29789119
Hyperaesthesia	24.11	10.22	57	161421	3516	29787484
Respiratory depression	23.95	10.22	124	161354	11379	29779621
Depressed level of consciousness	23.94	10.22	313	161165	37909	29753091
Suicidal behaviour	23.94	10.22	33	161445	1329	29789671
Localised infection	23.86	10.22	141	161337	13596	29777404
Colitis	23.54	10.22	86	161392	30734	29760266
Intervertebral disc degeneration	23.53	10.22	72	161406	5179	29785821
Ataxia	23.48	10.22	123	161355	11339	29779661
Personality change	23.41	10.22	66	161412	4534	29786466
Eosinophilia	23.41	10.22	53	161425	22107	29768893
Lethargy	23.26	10.22	320	161158	39199	29751801
Anger	23.24	10.22	120	161358	11000	29780000
Constipation	23.22	10.22	784	160694	112122	29678878
Angioedema	23.06	10.22	101	161377	34283	29756717
Gamma-glutamyltransferase increased	23.01	10.22	81	161397	29269	29761731
Acute myocardial infarction	22.93	10.22	179	161299	52760	29738240
Venoocclusive liver disease	22.91	10.22	4	161474	6609	29784391
Gait inability	22.89	10.22	177	161301	18664	29772336
Antidepressant drug level above therapeutic	22.68	10.22	13	161465	153	29790847
Muscular weakness	22.66	10.22	475	161003	63170	29727830
Cerebral infarction	22.60	10.22	70	161408	26303	29764697
Affective disorder	22.53	10.22	51	161427	3057	29787943
Cholangitis	22.51	10.22	7	161471	7795	29783205
Gastrointestinal haemorrhage	22.31	10.22	316	161162	83130	29707870
Erythema	22.26	10.22	289	161189	77162	29713838
Coordination abnormal	22.14	10.22	88	161390	7217	29783783
Transplant rejection	22.06	10.22	11	161467	9195	29781805
Rheumatoid arthritis	21.97	10.22	131	161347	41066	29749934
Neonatal toxicity	21.95	10.22	8	161470	28	29790972
Haematuria	21.63	10.22	147	161331	44687	29746313
Acute myeloid leukaemia	21.62	10.22	40	161438	17966	29773034
Mood altered	21.58	10.22	95	161383	8155	29782845
Toxic epidermal necrolysis	21.41	10.22	40	161438	17900	29773100
Pneumonitis	21.37	10.22	76	161402	27378	29763622
Facial pain	21.24	10.22	36	161442	1741	29789259
Colitis ulcerative	21.20	10.22	28	161450	14406	29776594
Encephalopathy neonatal	21.12	10.22	8	161470	32	29790968
Hypernatraemia	21.09	10.22	7	161471	7477	29783523
Hallucination, visual	21.06	10.22	154	161324	15959	29775041
Haematotoxicity	20.79	10.22	4	161474	6166	29784834
Plasma cell myeloma	20.69	10.22	404	161074	53058	29737942
Hypometabolism	20.56	10.22	8	161470	35	29790965
Labelled drug-drug interaction medication error	20.54	10.22	16	161462	10522	29780478
Feeding intolerance	20.43	10.22	9	161469	57	29790943
Acute respiratory distress syndrome	20.32	10.22	62	161416	23410	29767590
Transaminases increased	20.28	10.22	62	161416	23395	29767605
Sleep apnoea syndrome	20.28	10.22	158	161320	16699	29774301
Pathogen resistance	20.23	10.22	10	161468	8400	29782600
Myocardial infarction	20.21	10.22	519	160959	125106	29665894
Impaired driving ability	20.16	10.22	43	161435	2475	29788525
Anaphylactic reaction	20.13	10.22	80	161398	27902	29763098
Phantom limb syndrome	20.12	10.22	15	161463	283	29790717
Metabolic acidosis	20.04	10.22	119	161359	37342	29753658
Circulatory collapse	20.03	10.22	50	161428	20164	29770836
Epistaxis	19.88	10.22	186	161292	52795	29738205
Erectile dysfunction	19.79	10.22	166	161312	17936	29773064
Myocarditis	19.77	10.22	15	161463	9996	29781004
Hepatic enzyme increased	19.77	10.22	103	161375	33391	29757609
Joint hyperextension	19.71	10.22	8	161470	40	29790960
Binocular eye movement disorder	19.55	10.22	8	161470	41	29790959
Pancytopenia	19.38	10.22	332	161146	84720	29706280
Rash maculo-papular	19.36	10.22	71	161407	25347	29765653
Asthma	19.30	10.22	115	161363	36059	29754941
Cognitive disorder	19.27	10.22	204	161274	23486	29767514
Pleural effusion	19.26	10.22	282	161196	73784	29717216
Hostility	19.24	10.22	24	161454	875	29790125
Dyskinesia	19.18	10.22	191	161287	21643	29769357
Treatment failure	19.17	10.22	109	161369	34570	29756430
Conversion disorder	19.12	10.22	16	161462	359	29790641
Cerebral disorder	19.11	10.22	41	161437	2369	29788631
Leukopenia	19.05	10.22	202	161276	55957	29735043
Hepatocellular injury	18.85	10.22	72	161406	25399	29765601
Post transplant lymphoproliferative disorder	18.84	10.22	3	161475	5303	29785697
Pulmonary alveolar haemorrhage	18.82	10.22	6	161472	6575	29784425
Disorientation	18.73	10.22	255	161223	31163	29759837
Restless legs syndrome	18.64	10.22	80	161398	6792	29784208
Thinking abnormal	18.60	10.22	67	161411	5244	29785756
Posterior reversible encephalopathy syndrome	18.58	10.22	12	161466	8695	29782305
Intentional product misuse	18.52	10.22	276	161202	34391	29756609
Drug eruption	18.44	10.22	42	161436	17484	29773516
Hyperbilirubinaemia	18.32	10.22	40	161438	16902	29774098
Feeling drunk	18.30	10.22	32	161446	1587	29789413
Opisthotonus	18.29	10.22	16	161462	382	29790618
Precancerous skin lesion	18.25	10.22	19	161459	567	29790433
Analgesic drug level above therapeutic	18.05	10.22	13	161465	232	29790768
Infective pulmonary exacerbation of cystic fibrosis	18.04	10.22	12	161466	8560	29782440
Serotonin syndrome	17.95	10.22	161	161317	17730	29773270
Fibromyalgia	17.92	10.22	42	161436	2576	29788424
Metastases to liver	17.79	10.22	23	161455	11942	29779058
Ear deformity acquired	17.70	10.22	5	161473	5	29790995
Epstein-Barr virus infection	17.66	10.22	7	161471	6699	29784301
Cough	17.65	10.22	529	160949	125113	29665887
Blood creatinine increased	17.63	10.22	367	161111	91008	29699992
Blood lactate dehydrogenase increased	17.42	10.22	55	161423	20546	29770454
Musculoskeletal disorder	17.40	10.22	62	161416	4827	29786173
Hand deformity	17.38	10.22	34	161444	1839	29789161
Migraine	17.37	10.22	124	161354	12750	29778250
Nephropathy toxic	17.37	10.22	19	161459	10620	29780380
Seizure	17.34	10.22	672	160806	97803	29693197
Intervertebral disc protrusion	17.31	10.22	97	161381	9174	29781826
Blood creatine phosphokinase increased	17.29	10.22	152	161326	43696	29747304
Mental impairment	17.28	10.22	97	161381	9180	29781820
Liver disorder	17.20	10.22	92	161386	29630	29761370
Delirium	17.08	10.22	311	161167	40320	29750680
Hepatocellular carcinoma	17.01	10.22	16	161462	9594	29781406
Tumour lysis syndrome	16.96	10.22	27	161451	12858	29778142
Idiopathic neutropenia	16.91	10.22	4	161474	0	29791000
Agranulocytosis	16.90	10.22	61	161417	21881	29769119
Haemolysis	16.79	10.22	9	161469	7222	29783778
Stomatitis	16.64	10.22	125	161353	37154	29753846
Tubulointerstitial nephritis	16.40	10.22	46	161432	17845	29773155
Haemoglobin decreased	16.37	10.22	479	160999	113619	29677381
Immune reconstitution inflammatory syndrome	16.29	10.22	15	161463	9086	29781914
Urinary incontinence	16.27	10.22	151	161327	16789	29774211
Osteomyelitis	16.24	10.22	135	161343	14546	29776454
Heat exhaustion	16.07	10.22	9	161469	101	29790899
Aggression	16.05	10.22	284	161194	36623	29754377
Agitation	15.94	10.22	393	161085	53680	29737320
Appendicolith	15.75	10.22	22	161456	897	29790103
Metabolic encephalopathy	15.73	10.22	51	161427	3784	29787216
Shock haemorrhagic	15.69	10.22	18	161460	9847	29781153
Gingival atrophy	15.68	10.22	7	161471	46	29790954
Acute coronary syndrome	15.56	10.22	31	161447	13542	29777458
Ischaemic stroke	15.55	10.22	41	161437	16234	29774766
Sopor	15.50	10.22	107	161371	10884	29780116
Diplopia	15.43	10.22	127	161351	13645	29777355
Artery dissection	15.41	10.22	9	161469	110	29790890
Nephrotic syndrome	15.37	10.22	9	161469	6876	29784124
Thrombosis	15.29	10.22	316	161162	41915	29749085
Quality of life decreased	15.25	10.22	45	161433	3172	29787828
Dysphemia	15.12	10.22	28	161450	1453	29789547
Herpes zoster	15.07	10.22	236	161242	29707	29761293
Pulmonary toxicity	15.07	10.22	3	161475	4513	29786487
Drug screen negative	15.01	10.22	12	161466	252	29790748
Encephalitis	14.96	10.22	8	161470	6428	29784572
Prescribed overdose	14.95	10.22	88	161390	8473	29782527
Schizophrenia	14.95	10.22	16	161462	9032	29781968
Ventricular tachycardia	14.87	10.22	72	161406	23790	29767210
Tuberculosis	14.83	10.22	13	161465	8064	29782936
Body height decreased	14.72	10.22	49	161429	3685	29787315
Pulmonary tuberculosis	14.67	10.22	4	161474	4853	29786147
Muscle tightness	14.67	10.22	56	161422	4507	29786493
Enterocolitis	14.56	10.22	9	161469	6678	29784322
Rhabdomyolysis	14.54	10.22	248	161230	63332	29727668
Irritability	14.53	10.22	189	161289	22861	29768139
Acute hepatic failure	14.44	10.22	26	161452	11801	29779199
Thoracic vertebral fracture	14.42	10.22	27	161451	1413	29789587
Back injury	14.41	10.22	47	161431	3498	29787502
Synovitis	14.35	10.22	19	161459	9764	29781236
Foot fracture	14.08	10.22	52	161426	4120	29786880
Hyperkalaemia	13.98	10.22	261	161217	65749	29725251
Acute pulmonary oedema	13.92	10.22	12	161466	7503	29783497
Weight increased	13.85	10.22	514	160964	74399	29716601
Spinal stenosis	13.81	10.22	53	161425	4276	29786724
Blood pressure decreased	13.76	10.22	175	161303	46900	29744100
Shock	13.65	10.22	70	161408	22789	29768211
Blood urea increased	13.64	10.22	106	161372	31275	29759725
Mucosal atrophy	13.45	10.22	7	161471	67	29790933
Personality disorder	13.28	10.22	23	161455	1132	29789868
Free androgen index decreased	13.20	10.22	5	161473	20	29790980
Foetal disorder	13.19	10.22	17	161461	641	29790359
Tachycardia	13.12	10.22	300	161178	73439	29717561
Abnormal sleep-related event	13.10	10.22	15	161463	499	29790501
Mucormycosis	13.07	10.22	6	161472	5262	29785738
Mental disorder	12.97	10.22	120	161358	13329	29777671
Injection site mass	12.93	10.22	57	161421	4896	29786104
Autoimmune haemolytic anaemia	12.92	10.22	3	161475	4056	29786944
Lung disorder	12.89	10.22	108	161370	31361	29759639
Inflammation	12.85	10.22	68	161410	21958	29769042
Abdominal discomfort	12.75	10.22	349	161129	48442	29742558
Therapeutic response unexpected	12.75	10.22	87	161391	8816	29782184
Facial wasting	12.72	10.22	9	161469	156	29790844
Pancreatic fibrosis	12.69	10.22	3	161475	0	29791000
Severe myoclonic epilepsy of infancy	12.69	10.22	3	161475	0	29791000
Nasal odour	12.69	10.22	3	161475	0	29791000
Left ventricular dysfunction	12.62	10.22	17	161461	8674	29782326
Dysaesthesia	12.62	10.22	33	161445	2168	29788832
Hypoosmolar state	12.62	10.22	7	161471	77	29790923
Rectal haemorrhage	12.53	10.22	124	161354	34815	29756185
Eye injury	12.51	10.22	13	161465	387	29790613
Hepatitis	12.50	10.22	70	161408	22286	29768714
Hypersomnia	12.49	10.22	104	161374	11212	29779788
Dependence on respirator	12.48	10.22	5	161473	24	29790976
Palmar-plantar erythrodysaesthesia syndrome	12.36	10.22	40	161438	14830	29776170
Violence-related symptom	12.35	10.22	15	161463	532	29790468
Facet joint syndrome	12.35	10.22	10	161468	214	29790786
Candida infection	12.31	10.22	42	161436	15320	29775680
Radiculopathy	12.30	10.22	37	161441	2636	29788364
Hyperuricaemia	12.30	10.22	13	161465	7381	29783619
Neutrophil count increased	12.20	10.22	42	161436	15281	29775719
Hypoalbuminaemia	12.15	10.22	26	161452	11066	29779934
Stevens-Johnson syndrome	12.12	10.22	51	161427	17505	29773495
Hepatitis B	12.12	10.22	9	161469	6063	29784937
Dysphoria	12.11	10.22	32	161446	2116	29788884
Anaphylactic shock	12.08	10.22	37	161441	13956	29777044
Cytomegalovirus viraemia	12.08	10.22	8	161470	5721	29785279
Toxic skin eruption	11.91	10.22	26	161452	10989	29780011
Seborrhoeic keratosis	11.89	10.22	20	161458	961	29790039
Complex regional pain syndrome	11.87	10.22	14	161464	481	29790519
Laboratory test abnormal	11.84	10.22	145	161333	17297	29773703
Pneumothorax	11.83	10.22	46	161432	16147	29774853
Drug abuser	11.76	10.22	51	161427	4350	29786650
Hepatotoxicity	11.74	10.22	54	161424	18091	29772909
Panic disorder	11.73	10.22	22	161456	1153	29789847
Foetal heart rate disorder	11.71	10.22	5	161473	29	29790971
Psoriasis	11.69	10.22	160	161318	42346	29748654
Sensory disturbance	11.65	10.22	62	161416	5749	29785251
Slow speech	11.64	10.22	20	161458	978	29790022
Hypertriglyceridaemia	11.60	10.22	16	161462	8082	29782918
Hyperthyroidism	11.60	10.22	16	161462	8082	29782918
Mouth ulceration	11.51	10.22	25	161453	10584	29780416
Drug effective for unapproved indication	11.50	10.22	21	161457	1078	29789922
Hypotension	11.49	10.22	928	160550	199637	29591363
Erysipelas	11.47	10.22	5	161473	4519	29786481
Oesophageal mucosa erythema	11.44	10.22	5	161473	31	29790969
Haemorrhage intracranial	11.44	10.22	42	161436	14990	29776010
Acute graft versus host disease in skin	11.43	10.22	5	161473	4511	29786489
Post herpetic neuralgia	11.39	10.22	20	161458	995	29790005
Breakthrough pain	11.39	10.22	15	161463	578	29790422
Swelling	11.37	10.22	264	161214	35711	29755289
Panic attack	11.36	10.22	83	161395	8598	29782402
Chronic graft versus host disease	11.35	10.22	4	161474	4115	29786885
Fracture	11.32	10.22	63	161415	5943	29785057
Teeth brittle	11.31	10.22	6	161472	60	29790940
Walking disability	11.30	10.22	17	161461	742	29790258
Lymphoedema	11.30	10.22	43	161435	3456	29787544
Dissociative disorder	11.29	10.22	8	161470	139	29790861
Neck pain	11.28	10.22	167	161311	20777	29770223
Nerve compression	11.25	10.22	37	161441	2765	29788235
Lower respiratory tract infection	11.25	10.22	91	161387	26623	29764377
Incoherent	11.21	10.22	48	161430	4070	29786930
Hyperfibrinogenaemia	11.20	10.22	4	161474	13	29790987
Blood alkaline phosphatase increased	11.19	10.22	112	161366	31375	29759625
Nephrogenic systemic fibrosis	11.18	10.22	50	161428	4321	29786679
Dependence	11.07	10.22	22	161456	1204	29789796
Lymphocyte count decreased	11.02	10.22	59	161419	18996	29772004
Hyperglycaemia	10.99	10.22	129	161349	35071	29755929
Genital burning sensation	10.97	10.22	4	161474	14	29790986
Abnormal labour affecting foetus	10.97	10.22	4	161474	14	29790986
Myelosuppression	10.96	10.22	14	161464	7308	29783692
Neurogenic bladder	10.90	10.22	26	161452	1613	29789387
Drug tolerance increased	10.83	10.22	12	161466	385	29790615
Respiratory disorder	10.77	10.22	53	161425	17441	29773559
Second primary malignancy	10.77	10.22	11	161467	6345	29784655
Neck surgery	10.76	10.22	11	161467	321	29790679
Fear of weight gain	10.76	10.22	4	161474	15	29790985
Immunosuppressant drug level increased	10.70	10.22	6	161472	4696	29786304
Lumbar radiculopathy	10.70	10.22	18	161460	865	29790135
Decreased interest	10.69	10.22	31	161447	2164	29788836
Tongue movement disturbance	10.66	10.22	6	161472	68	29790932
Multiple cardiac defects	10.66	10.22	6	161472	68	29790932
Carcinogenicity	10.66	10.22	6	161472	68	29790932
Autonomic nervous system imbalance	10.66	10.22	33	161445	2388	29788612
Lipodystrophy acquired	10.63	10.22	3	161475	3557	29787443
Joint injury	10.63	10.22	67	161411	6610	29784390
Premature baby	10.61	10.22	50	161428	16641	29774359
Disturbance in attention	10.60	10.22	173	161305	21956	29769044
Osteonecrosis of jaw	10.57	10.22	58	161420	18560	29772440
Rib fracture	10.56	10.22	110	161368	12610	29778390
Developmental hip dysplasia	10.54	10.22	10	161468	266	29790734
Incision site complication	10.49	10.22	11	161467	331	29790669
Ventricular septal defect	10.49	10.22	3	161475	3526	29787474
Aphasia	10.47	10.22	155	161323	19284	29771716
Haematochezia	10.46	10.22	126	161352	34096	29756904
Immunodeficiency common variable	10.38	10.22	8	161470	159	29790841
Myelomalacia	10.37	10.22	5	161473	40	29790960
Intervertebral disc injury	10.37	10.22	4	161474	17	29790983
Road traffic accident	10.35	10.22	139	161339	16932	29774068
White blood cell count increased	10.33	10.22	151	161327	39522	29751478
Cardio-respiratory arrest	10.30	10.22	392	161086	56914	29734086
Arthrofibrosis	10.30	10.22	6	161472	73	29790927
Bipolar disorder	10.27	10.22	44	161434	3732	29787268
Dysstasia	10.27	10.22	94	161384	10411	29780589

Pharmacologic Action:

Source	Code	Description
ATC	N03AX12	NERVOUS SYSTEM ANTIEPILEPTICS ANTIEPILEPTICS Other antiepileptics
FDA PE	N0000008486	Decreased Central Nervous System Disorganized Electrical Activity
FDA EPC	N0000175753	Anti-epileptic Agent
MeSH PA	D000700	Analgesics
MeSH PA	D014151	Anti-Anxiety Agents
MeSH PA	D000927	Anticonvulsants
MeSH PA	D018692	Antimanic Agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D018691	Excitatory Amino Acid Antagonists
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D011619	Psychotropic Drugs
MeSH PA	D018689	Sensory System Agents
MeSH PA	D014149	Tranquilizing Agents
CHEBI has role	CHEBI:35623	antiepileptic
CHEBI has role	CHEBI:35703	xenobiotic
CHEBI has role	CHEBI:38215	calcium channel blockers
CHEBI has role	CHEBI:78298	environmental contaminants

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Postherpetic neuralgia	indication	2177002
Restless legs	indication	32914008	DOID:0050425
Partial Epilepsy Treatment Adjunct	indication
Alcohol use disorder	off-label use	7200002
Menopausal night sweats	off-label use	42984000
Chronic cough	off-label use	68154008
Chronic pain	off-label use	82423001
Insomnia	off-label use	193462001
Anxiety disorder	off-label use	197480006	DOID:2030
Menopausal flushing	off-label use	198436008
Fibromyalgia	off-label use	203082005	DOID:631
Neuropathic pain	off-label use	247398009
Chronic pruritus	off-label use	418363000
Refractory pruritis	off-label use	418363000
Post-stroke nausea	off-label use	422587007
Essential tremor	off-label use	609558009	DOID:4990
Intractable hiccups	off-label use	716771000
Acute postoperative pain	off-label use	107401000119105
Suicidal thoughts	contraindication	6471006
Depressive disorder	contraindication	35489007
Kidney disease	contraindication	90708001	DOID:557

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.02	acidic
pKa2	10.31	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Voltage-dependent calcium channel subunit alpha-2/delta-1	Ion channel	P54289	CA2D1_HUMAN	MODULATOR	IC50	7.26	WOMBAT-PK	CHEMBL
Voltage-dependent calcium channel subunit alpha-2/delta-2	Ion channel	Q9NY47	CA2D2_HUMAN	MODULATOR	IC50	6.93	SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE
Large neutral amino acids transporter small subunit 1	Transporter	Q01650	LAT1_HUMAN		IC50	4.52	WOMBAT-PK
Glutamate receptor ionotropic, NMDA 3A	Ion channel	Q8TCU5	NMD3A_HUMAN				WOMBAT-PK
Gamma-aminobutyric acid type B receptor subunit 2	GPCR	O75899	GABR2_HUMAN				WOMBAT-PK
Adenosine receptor A1	GPCR	P30542	AA1R_HUMAN				WOMBAT-PK
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN				WOMBAT-PK
Sodium channel protein type 5 subunit alpha	Ion channel	Q14524	SCN5A_HUMAN				WOMBAT-PK
Voltage-dependent calcium channel subunit alpha-2/delta-1	Ion channel		CA2D1_MOUSE		Ki	6.92	CHEMBL
Uncharacterized protein; Voltage-dependent calcium channel alpha-2 delta subunit	Ion channel		O77773_PIG		IC50	7.15	CHEMBL

External reference:

ID	Source
4020833	VUID
N0000148345	NUI
D00332	KEGG_DRUG
4020833	VANDF
C0060926	UMLSCUI
CHEBI:42797	CHEBI
GBN	PDB_CHEM_ID
CHEMBL940	ChEMBL_ID
DB00996	DRUGBANK_ID
D000077206	MESH_DESCRIPTOR_UI
5483	IUPHAR_LIGAND_ID
5094	INN_ID
6CW7F3G59X	UNII
3446	PUBCHEM_CID
196498	RXNORM
2269	MMSL
4770	MMSL
60712	MMSL
d03182	MMSL
004415	NDDF
108402001	SNOMEDCT_US
386845007	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Neurontin	HUMAN PRESCRIPTION DRUG LABEL	1	0071-0401	TABLET, FILM COATED	800 mg	ORAL	NDA	31 sections
Neurontin	HUMAN PRESCRIPTION DRUG LABEL	1	0071-0513	TABLET, FILM COATED	600 mg	ORAL	NDA	31 sections
Neurontin	HUMAN PRESCRIPTION DRUG LABEL	1	0071-0803	CAPSULE	100 mg	ORAL	NDA	31 sections
Neurontin	HUMAN PRESCRIPTION DRUG LABEL	1	0071-0805	CAPSULE	300 mg	ORAL	NDA	31 sections
Neurontin	HUMAN PRESCRIPTION DRUG LABEL	1	0071-0806	CAPSULE	400 mg	ORAL	NDA	31 sections
Neurontin	HUMAN PRESCRIPTION DRUG LABEL	1	0071-2012	SOLUTION	250 mg	ORAL	NDA	31 sections
Gabapentin	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2636	TABLET, FILM COATED	600 mg	ORAL	ANDA	26 sections
Gabapentin	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2637	TABLET, FILM COATED	800 mg	ORAL	ANDA	26 sections
GABAPENTIN	HUMAN PRESCRIPTION DRUG LABEL	1	0440-5562	TABLET, FILM COATED	600 mg	ORAL	ANDA	24 sections
GABAPENTIN	HUMAN PRESCRIPTION DRUG LABEL	1	0440-5563	TABLET, FILM COATED	800 mg	ORAL	ANDA	24 sections
Gabapentin	HUMAN PRESCRIPTION DRUG LABEL	1	0440-7559	CAPSULE	300 mg	ORAL	ANDA	14 sections
Gabapentin	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8132	TABLET	800 mg	ORAL	ANDA	29 sections
Gabapentin	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8230	CAPSULE	100 mg	ORAL	ANDA	29 sections
Gabapentin	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8231	CAPSULE	300 mg	ORAL	ANDA	29 sections
Gabapentin	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8232	CAPSULE	400 mg	ORAL	ANDA	29 sections
Gabapentin	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8233	TABLET	600 mg	ORAL	ANDA	29 sections
Gabapentin	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8340	CAPSULE	100 mg	ORAL	ANDA	26 sections
Gabapentin	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8341	CAPSULE	300 mg	ORAL	ANDA	26 sections
Gabapentin	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8342	CAPSULE	400 mg	ORAL	ANDA	26 sections
Gabapentin	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6586	TABLET, FILM COATED	800 mg	ORAL	ANDA	25 sections
Gabapentin	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6665	CAPSULE	100 mg	ORAL	ANDA	30 sections
Gabapentin	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6666	CAPSULE	300 mg	ORAL	ANDA	30 sections
Gabapentin	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6667	CAPSULE	400 mg	ORAL	ANDA	30 sections
Gabapentin	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6823	TABLET, FILM COATED	600 mg	ORAL	ANDA	30 sections
Gabapentin	HUMAN PRESCRIPTION DRUG LABEL	1	0904-7108	TABLET, FILM COATED	800 mg	ORAL	ANDA	30 sections
Gabapentin	HUMAN PRESCRIPTION DRUG LABEL	1	10135-644	CAPSULE	100 mg	ORAL	ANDA	30 sections
Gabapentin	HUMAN PRESCRIPTION DRUG LABEL	1	10135-645	CAPSULE	300 mg	ORAL	ANDA	30 sections
Gabapentin	HUMAN PRESCRIPTION DRUG LABEL	1	10135-646	CAPSULE	400 mg	ORAL	ANDA	30 sections
Gabapentin	HUMAN PRESCRIPTION DRUG LABEL	1	10135-647	TABLET	600 mg	ORAL	ANDA	30 sections
Gabapentin	HUMAN PRESCRIPTION DRUG LABEL	1	10135-648	TABLET	800 mg	ORAL	ANDA	30 sections