aminobutyric acid Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1262 56-12-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • GABA
  • 4-aminobutanoic acid
  • piperidic acid
  • 4-aminobutyric acid
  • gaballon
  • aminalon
  • aminobutyric acid
  • .GAMMA.-AMINOBUTYRIC ACID
  • gamma-Aminobutyric Acid
The most common inhibitory neurotransmitter in the central nervous system.
  • Molecular weight: 103.12
  • Formula: C4H9NO2
  • CLOGP: -2.77
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 63.32
  • ALOGS: 0.55
  • ROTB: 3

Drug dosage:

DoseUnitRoute
1 g O
1 g P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC N03AG03 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Fatty acid derivatives
CHEBI has role CHEBI:25512 neurotransmitters
CHEBI has role CHEBI:62488 signaling molecules
CHEBI has role CHEBI:75772 baker's yeast metabolite
CHEBI has role CHEBI:77746 h. sapiens metabolites
MeSH PA D018682 GABA Agents
MeSH PA D018377 Neurotransmitter Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.87 acidic
pKa2 10.45 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Gamma-aminobutyric acid receptor subunit rho-1 Ion channel EC50 6.57 CHEMBL
Sodium- and chloride-dependent GABA transporter 1 Transporter IC50 5.30 CHEMBL
Sodium- and chloride-dependent GABA transporter 3 Transporter IC50 5.15 CHEMBL
Sodium- and chloride-dependent betaine transporter Transporter IC50 4.44 CHEMBL
Gamma-aminobutyric acid receptor subunit gamma-1 Ion channel IC50 7.48 CHEMBL
Gamma-aminobutyric acid receptor subunit alpha-2 Ion channel IC50 7.66 CHEMBL
Sodium- and chloride-dependent GABA transporter 1 Transporter IC50 5.59 CHEMBL
Sodium- and chloride-dependent GABA transporter 2 Unclassified IC50 5.30 CHEMBL
Sodium- and chloride-dependent GABA transporter 1 Transporter IC50 5.14 CHEMBL
Sodium- and chloride-dependent GABA transporter 2 Unclassified IC50 4.56 CHEMBL
Sodium- and chloride-dependent GABA transporter 3 Unclassified IC50 5.09 CHEMBL
Gamma-aminobutyric acid receptor subunit alpha-1 Ion channel EC50 5 CHEMBL

External reference:

IDSource
2ACZ6IPC6I UNII
4034308 VUID
N0000191506 NUI
4034308 VANDF
C0016904 UMLSCUI
CHEBI:16865 CHEBI
ABU PDB_CHEM_ID
CHEMBL96 ChEMBL_ID
119 PUBCHEM_CID
DB02530 DRUGBANK_ID
D000613 MESH_DESCRIPTOR_UI
D005680 MESH_DESCRIPTOR_UI
1067 IUPHAR_LIGAND_ID
4617 RXNORM
006466 NDDF
259100002 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Dairy Allergen Mix HUMAN OTC DRUG LABEL 38 43742-1277 LIQUID 8 [hp_X] ORAL unapproved drug other 9 sections
Gongjinhyang Qi and Jin Eye HUMAN OTC DRUG LABEL 1 53208-500 CREAM 0.02 mL TOPICAL unapproved drug other 10 sections