Stem definition | Drug id | CAS RN |
---|---|---|
1261 | 6990-06-3 |
Dose | Unit | Route |
---|---|---|
1.50 | g | O |
1.50 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Bocci G, Oprea TI, Benet LZ |
BA (Bioavailability) | 91 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
S (Water solubility) | 50 mg/mL | Bocci G, Oprea TI, Benet LZ |
None
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Eczema herpeticum | 50.73 | 24.46 | 8 | 1945 | 161 | 63486908 |
Biliary sepsis | 48.61 | 24.46 | 10 | 1943 | 921 | 63486148 |
Monocytosis | 41.13 | 24.46 | 8 | 1945 | 554 | 63486515 |
Rash maculo-papular | 38.37 | 24.46 | 19 | 1934 | 31877 | 63455192 |
Rhabdomyolysis | 38.05 | 24.46 | 21 | 1932 | 43930 | 63443139 |
Scab | 35.28 | 24.46 | 12 | 1941 | 7751 | 63479318 |
Hyperlipasaemia | 33.39 | 24.46 | 7 | 1946 | 706 | 63486363 |
Ulcerative keratitis | 33.24 | 24.46 | 9 | 1944 | 2701 | 63484368 |
Vulvovaginal inflammation | 32.26 | 24.46 | 7 | 1946 | 832 | 63486237 |
Exposure to SARS-CoV-2 | 32.08 | 24.46 | 8 | 1945 | 1743 | 63485326 |
Corneal neovascularisation | 31.19 | 24.46 | 5 | 1948 | 112 | 63486957 |
Dermatitis allergic | 30.78 | 24.46 | 13 | 1940 | 15135 | 63471934 |
Impetigo | 28.97 | 24.46 | 7 | 1946 | 1339 | 63485730 |
Reperfusion arrhythmia | 27.52 | 24.46 | 5 | 1948 | 239 | 63486830 |
Erythema | 26.97 | 24.46 | 30 | 1923 | 175721 | 63311348 |
Eye inflammation | 26.80 | 24.46 | 9 | 1944 | 5590 | 63481479 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Rhabdomyolysis | 194.68 | 29.13 | 82 | 1450 | 68081 | 34887318 |
Drug interaction | 60.68 | 29.13 | 61 | 1471 | 225885 | 34729514 |
Chromaturia | 56.73 | 29.13 | 22 | 1510 | 14498 | 34940901 |
Labelled drug-drug interaction medication error | 52.62 | 29.13 | 21 | 1511 | 14918 | 34940481 |
Myalgia | 41.11 | 29.13 | 32 | 1500 | 84078 | 34871321 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Rhabdomyolysis | 224.96 | 20.54 | 104 | 3501 | 103027 | 79637756 |
Drug interaction | 64.31 | 20.54 | 86 | 3519 | 415097 | 79325686 |
Labelled drug-drug interaction medication error | 51.22 | 20.54 | 25 | 3580 | 27625 | 79713158 |
Eczema herpeticum | 49.27 | 20.54 | 9 | 3596 | 299 | 79740484 |
Rash maculo-papular | 41.88 | 20.54 | 28 | 3577 | 56050 | 79684733 |
Biliary sepsis | 39.27 | 20.54 | 10 | 3595 | 1607 | 79739176 |
Scab | 37.20 | 20.54 | 15 | 3590 | 10557 | 79730226 |
Cholestasis | 34.13 | 20.54 | 24 | 3581 | 52085 | 79688698 |
Monocytosis | 33.27 | 20.54 | 8 | 3597 | 1016 | 79739767 |
Chromaturia | 32.50 | 20.54 | 18 | 3587 | 25728 | 79715055 |
Exposure to SARS-CoV-2 | 27.79 | 20.54 | 8 | 3597 | 2036 | 79738747 |
Corneal neovascularisation | 27.58 | 20.54 | 5 | 3600 | 159 | 79740624 |
Ulcerative keratitis | 27.07 | 20.54 | 9 | 3596 | 3680 | 79737103 |
Hyperlipasaemia | 26.78 | 20.54 | 7 | 3598 | 1247 | 79739536 |
Dermatitis allergic | 26.58 | 20.54 | 14 | 3591 | 18116 | 79722667 |
Reperfusion arrhythmia | 24.57 | 20.54 | 5 | 3600 | 295 | 79740488 |
Vitamin K decreased | 24.25 | 20.54 | 4 | 3601 | 72 | 79740711 |
Impetigo | 23.26 | 20.54 | 7 | 3598 | 2076 | 79738707 |
Erythema | 22.58 | 20.54 | 38 | 3567 | 223252 | 79517531 |
Eye inflammation | 22.22 | 20.54 | 9 | 3596 | 6404 | 79734379 |
Gastrointestinal submucosal tumour | 22.07 | 20.54 | 4 | 3601 | 127 | 79740656 |
Myalgia | 22.05 | 20.54 | 34 | 3571 | 185607 | 79555176 |
Vulvovaginal inflammation | 21.58 | 20.54 | 5 | 3600 | 541 | 79740242 |
None
Source | Code | Description |
---|---|---|
ATC | D06AX01 | DERMATOLOGICALS ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE ANTIBIOTICS FOR TOPICAL USE Other antibiotics for topical use |
ATC | D09AA02 | DERMATOLOGICALS MEDICATED DRESSINGS MEDICATED DRESSINGS Medicated dressings with antiinfectives |
ATC | J01XC01 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER ANTIBACTERIALS Steroid antibacterials |
ATC | S01AA13 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Antibiotics |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D011500 | Protein Synthesis Inhibitors |
CHEBI has role | CHEBI:48001 | protein synthesis inhibitors |
CHEBI has role | CHEBI:76971 | Escherichia coli metabolites |
CHEBI has role | CHEBI:77194 | ATP:pantothenate 4-phosphotransferase inhibitor |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Trachoma | indication | 2576002 | DOID:11265 |
Listeriosis | indication | 4241002 | DOID:11573 |
Septicemia due to Escherichia coli | indication | 9323009 | |
Bacterial septicemia | indication | 10001005 | DOID:0040085 |
Infection due to Pseudomonas aeruginosa | indication | 11218009 | |
Inhalational anthrax | indication | 11389007 | |
Actinomycotic infection | indication | 11817007 | DOID:8478 |
Folliculitis | indication | 13600006 | DOID:4409 |
Gonorrhea | indication | 15628003 | DOID:7551 |
Pneumococcal infectious disease | indication | 16814004 | |
Tularemia | indication | 19265001 | |
Infection of skin AND/OR subcutaneous tissue | indication | 19824006 | |
Gingivostomatitis | indication | 20607006 | |
Acute gonococcal cervicitis | indication | 20943002 | DOID:10615 |
Staphylococcal pneumonia | indication | 22754005 | |
Murine typhus | indication | 25668000 | DOID:11256 |
Granuloma inguinale | indication | 28867007 | DOID:9113 |
Acute gonococcal urethritis | indication | 29864006 | |
Acute gonococcal epididymo-orchitis | indication | 30168008 | DOID:10802 |
Bronchitis | indication | 32398004 | DOID:6132 |
Sinusitis | indication | 36971009 | |
Disease caused by rickettsiae | indication | 37246009 | |
Louse-borne typhus | indication | 39111003 | DOID:11256 |
Pneumonia due to Pseudomonas | indication | 41381004 | |
Punctate keratitis | indication | 42513006 | DOID:12197 |
Gonorrhea of rectum | indication | 42746002 | |
Pneumonia due to Mycoplasma pneumoniae | indication | 46970008 | |
Brill-Zinsser disease | indication | 47761007 | DOID:11254 |
Peritonitis | indication | 48661000 | |
Pneumonia due to Escherichia coli | indication | 51530003 | |
Bacterial pneumonia | indication | 53084003 | DOID:874 |
Staphylococcal infectious disease | indication | 56038003 | |
Cholera | indication | 63650001 | DOID:1498 |
Acute gonococcal endometritis | indication | 65295003 | DOID:7527 |
Urinary tract infectious disease | indication | 68566005 | |
Blepharoconjunctivitis | indication | 68659002 | DOID:2456 |
Yaws | indication | 70647001 | DOID:10371 |
Infection due to Escherichia coli | indication | 71057007 | |
Bacterial infection due to Serratia | indication | 71120004 | |
Paronychia | indication | 71906005 | DOID:13117 |
Rhinoscleroma | indication | 72409005 | DOID:11336 |
Gonorrhea of pharynx | indication | 74372003 | |
Perforation of cornea | indication | 74895004 | |
Rickettsialpox | indication | 75096007 | DOID:11103 |
Ornithosis | indication | 75116005 | DOID:11262 |
Acute bacterial sinusitis | indication | 75498004 | |
Brucellosis | indication | 75702008 | DOID:11077 |
Syphilis | indication | 76272004 | |
Septicemia due to Serratia | indication | 82091000 | |
Cholangitis | indication | 82403002 | DOID:9446 |
Nongonococcal urethritis | indication | 84619001 | |
Cutaneous anthrax | indication | 84980006 | DOID:7426 |
Streptococcal infectious disease | indication | 85769006 | |
Dacryocystitis | indication | 85777005 | DOID:9938 |
Corneal abrasion | indication | 85848002 | |
Keratoconjunctivitis | indication | 88151007 | DOID:9368 |
Acne vulgaris | indication | 88616000 | |
Bacterial meningitis | indication | 95883001 | DOID:9470 |
Q fever endocarditis | indication | 95890006 | |
Chlamydial infection | indication | 105629000 | |
Infection of bone | indication | 111253001 | |
Gastrointestinal anthrax | indication | 111798006 | DOID:13386 |
Furunculosis | indication | 112650006 | |
Infectious disease of abdomen | indication | 128070006 | |
Bacterial conjunctivitis | indication | 128350005 | DOID:9700 |
Uveitis | indication | 128473001 | DOID:13141 |
Bacterial infection of skin | indication | 128936008 | |
Infection due to Enterobacteriaceae | indication | 128945009 | |
Bacterial infection due to Klebsiella pneumoniae | indication | 186435004 | |
Rocky Mountain spotted fever | indication | 186772009 | |
Boutonneuse fever | indication | 186774005 | DOID:14095 |
Q fever | indication | 186788009 | DOID:11100 |
Lymphogranuloma venereum | indication | 186946009 | DOID:13819 |
Proteus pneumonia | indication | 195888009 | |
Bacterial peritonitis | indication | 197171003 | |
Sepsis of the newborn | indication | 206376005 | |
Pneumonia | indication | 233604007 | DOID:552 |
Neonatal pneumonia | indication | 233619008 | |
Inclusion conjunctivitis | indication | 266109000 | |
Bartonellosis | indication | 266123003 | DOID:11102 |
Chancroid | indication | 266143009 | DOID:13778 |
Scrub typhus | indication | 271425001 | DOID:13371 |
Neonatal meningitis | indication | 276674008 | |
Proteus septicemia | indication | 300986008 | |
Escherichia coli urinary tract infection | indication | 301011002 | |
Meibomianitis | indication | 309779001 | |
Bacterial urinary infection | indication | 312124009 | |
Infective otitis media | indication | 312218008 | |
Infective blepharitis | indication | 312219000 | |
Bacterial keratitis | indication | 314557000 | |
Infectious disorder of joint | indication | 363162000 | |
Herpes zoster keratitis | indication | 397573005 | |
Rosacea | indication | 398909004 | DOID:8881 |
Pharyngitis | indication | 405737000 | DOID:2275 |
Infection due to Staphylococcus aureus | indication | 406602003 | |
Anthrax | indication | 409498004 | DOID:7427 |
Anterior uveitis | indication | 410692006 | DOID:1407 |
Relapsing fever | indication | 420079008 | DOID:13034 |
Nosocomial pneumonia | indication | 425464007 | |
Chlamydia trachomatis infection of genital structure | indication | 428015005 | |
Osteomyelitis due to Staphylococcus aureus | indication | 428783003 | |
Sepsis due to Pseudomonas | indication | 448813005 | |
Sepsis due to Gram negative bacteria | indication | 449082003 | |
Allergic conjunctivitis | indication | 473460002 | DOID:11204 |
Urinary tract infection caused by Klebsiella | indication | 369001000119100 | |
Disseminated Gonococcal Infection | indication | ||
Complicated Proteus UTI | indication | ||
Synergy for Staphylococcal Joint Infection | indication | ||
Providencia Complicated UTI | indication | ||
Superficial Ocular Infection | indication | ||
Synergy for Group B Streptococcal Septicemia | indication | ||
Synergy for Staphylococcal Endocarditis | indication | ||
Synergy for Pseudomonas Aeruginosa Septicemia | indication | ||
Synergy for Pseudomonas Aeruginosa Pneumonia | indication | ||
Synergy for Serratia Meningitis | indication | ||
E. Coli Osteomyelitis | indication | ||
Burn Wound Infections | indication | ||
Klebsiella Pneumoniae Peritonitis | indication | ||
Skin and Skin Structure Citrobacter Infection | indication | ||
Chloroquine-Resistant Plasmodium Falciparum Malaria Prevention | indication | ||
Pseudomonas Aeruginosa Biliary Tract Infection | indication | ||
Citrobacter Septicemia | indication | ||
Synergy for Skin and Skin Structure Pseudomonas Aeruginosa Infection | indication | ||
Synergy for Pseudomonas Aeruginosa Osteomyelitis | indication | ||
Skin and Skin Structure Serratia Infection | indication | ||
Citrobacter Complicated UTI | indication | ||
Synergy for Staphylococcal Septicemia | indication | ||
Synergy for Pseudomonas Aeruginosa Meningitis | indication | ||
Serratia Complicated UTI | indication | ||
Staphylococcus Aureus Complicated UTI | indication | ||
Synergy for Neonatal Meningitis | indication | ||
Synergy for Escherichia Coli Meningitis | indication | ||
Enterobacter Osteomyelitis | indication | ||
Complicated Bacterial Peritonitis | indication | ||
Gram-Negative Aerobic Bacillary Pneumonia | indication | ||
Synergy for Nosocomial Pneumonia due to Pseudomonas Aeruginosa | indication | ||
Pseudomonas Aeruginosa Joint Infection | indication | ||
Synergy for Staphylococcus Aureus Pneumonia | indication | ||
Synergy for Klebsiella Meningitis | indication | ||
Rectal Chlamydia Trachomatis Infection | indication | ||
Skin and Skin Structure Pseudomonas Aeruginosa Infection | indication | ||
Pseudomonas Aeruginosa Osteomyelitis | indication | ||
Synergy for Bacterial Meningitis | indication | ||
Synergy for P. Aeruginosa Infection in Cystic Fibrosis | indication | ||
Pseudomonas Aeruginosa Meningitis | indication | ||
Proteus Mirabilis Osteomyelitis | indication | ||
Citrobacter Pneumonia | indication | ||
Synergy for Proteus Meningitis | indication | ||
Synergy for Pseudomonas Aeruginosa Joint Infection | indication | ||
Synergy for Staphylococcus Skin and Skin Structure Infection | indication | ||
Klebsiella Septicemia | indication | ||
Complicated UTI with Pseudomonas Aeruginosa | indication | ||
Typhus Infections | indication | ||
Synergy for Staphylococcal Infections | indication | ||
Enterobacter Pneumonia | indication | ||
Klebsiella Pneumoniae Osteomyelitis | indication | ||
Complicated Urinary Tract Infections | indication | ||
Synergy for Enterobacter Meningitis | indication | ||
E. Coli Peritonitis | indication | ||
Skin and Skin Structure Proteus Infection | indication | ||
Synergy for Citrobacter Meningitis | indication | ||
Necrotizing enterocolitis in fetus OR newborn | off-label use | 2707005 | |
Pyrexia of unknown origin | off-label use | 7520000 | |
Traveler's diarrhea | off-label use | 11840006 | |
Exposure keratoconjunctivitis | off-label use | 14366000 | DOID:9461 |
Ecthyma gangrenosum | off-label use | 17732003 | |
Enteric campylobacteriosis | off-label use | 18081009 | |
Lyme disease | off-label use | 23502006 | DOID:11729 |
Vivax malaria | off-label use | 27052006 | DOID:12978 |
Lyme arthritis | off-label use | 33937009 | |
Pseudotuberculosis | off-label use | 36753006 | |
Enterocolitis | off-label use | 43752006 | |
Plague | off-label use | 58750007 | DOID:3482 |
Malaria | off-label use | 61462000 | DOID:12365 |
Ehrlichiosis | off-label use | 77361002 | |
Leptospirosis | off-label use | 77377001 | DOID:2297 |
Lyme carditis | off-label use | 77863005 | |
Infection by Yersinia enterocolitica | off-label use | 80960004 | |
Atypical mycobacterial infection | off-label use | 111812000 | |
Infection by Campylobacter fetus | off-label use | 111835002 | |
Ocular rosacea | off-label use | 200933006 | |
Neuropathic corneal ulcer | off-label use | 231901007 | |
Chlamydial epididymitis | off-label use | 236767000 | |
Synergy for Enterococcal Endocarditis | off-label use | ||
Sexual Transmitted Disease Exposure from Sexual Assault | off-label use | ||
Listeria Monocytogenes Septicemia | off-label use | ||
Synergy for Enterococcal Infections | off-label use | ||
Postexposure Plague Prophylaxis | off-label use | ||
Lyme Disease Prevention | off-label use | ||
Synergy for Prevention of Enterococcal Endocarditis | off-label use | ||
Periodontitis Adjunct Therapy | off-label use | ||
Chloroquine Resistant Plasmodium Falciparum Malaria | off-label use | ||
Pseudomonas Respiratory Tract Infection in Cystic Fibrosis | off-label use | ||
Synergy for Streptococcal Endocarditis | off-label use | ||
Pleural Malignant Effusions | off-label use | ||
Synergy for Listeria Monocytogenes Septicemia | off-label use | ||
Prevention of Perioperative Infection | off-label use | ||
Ocular hypertension | contraindication | 4210003 | DOID:9282 |
Hypocalcemia | contraindication | 5291005 | |
Herpes simplex keratitis | contraindication | 9389005 | |
Glaucoma | contraindication | 23986001 | DOID:1686 |
Complete atrioventricular block | contraindication | 27885002 | |
Shock | contraindication | 27942005 | |
Hypovolemia | contraindication | 28560003 | |
Herpes simplex dendritic keratitis | contraindication | 29943008 | |
Fungal infection of eye | contraindication | 31194008 | |
Parkinsonism | contraindication | 32798002 | |
Dehydration | contraindication | 34095006 | |
Severe myopia | contraindication | 34187009 | |
Hypokalemia | contraindication | 43339004 | |
Stokes-Adams syndrome | contraindication | 46935006 | |
Chronic heart failure | contraindication | 48447003 | |
Tuberculosis of eye | contraindication | 49107007 | |
Atrial fibrillation | contraindication | 49436004 | DOID:0060224 |
Sinus bradycardia | contraindication | 49710005 | |
Disorder of digestive system | contraindication | 53619000 | DOID:77 |
Acute nephropathy | contraindication | 58574008 | |
Hepatic failure | contraindication | 59927004 | |
Tinnitus | contraindication | 60862001 | |
Colitis | contraindication | 64226004 | DOID:0060180 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Wolff-Parkinson-White pattern | contraindication | 74390002 | DOID:384 |
Decreased respiratory function | contraindication | 80954004 | |
Open-angle glaucoma | contraindication | 84494001 | DOID:1067 |
Krukenberg spindle | contraindication | 85430004 | |
Herpes zoster ophthalmicus | contraindication | 87513003 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Eye infection | contraindication | 128351009 | |
Bacterial infection of eye | contraindication | 128984004 | |
Hypomagnesemia | contraindication | 190855004 | |
Partial atrioventricular block | contraindication | 195039008 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Esophageal dysmotility | contraindication | 266434009 | DOID:9192 |
Pregnancy, function | contraindication | 289908002 | |
Viral eye infection | contraindication | 312132001 | |
Hypoxia | contraindication | 389086002 | |
Vaccinia keratitis | contraindication | 397552005 | |
Pseudomembranous enterocolitis | contraindication | 397683000 | |
Vertigo | contraindication | 399153001 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Denuded skin | contraindication | 418242004 | |
Gentamicin Toxicity | contraindication | ||
Reduced Hepatic Blood Flow | contraindication | ||
Disorder of the 8th Cranial Nerve | contraindication | ||
Infant Botulism | contraindication | ||
Tobramycin Toxicity | contraindication | ||
Lidocaine Toxicity | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 4.75 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
ATP-binding cassette sub-family G member 2 | Transporter | IC50 | 4.28 | CHEMBL | |||||
Bile salt export pump | Transporter | IC50 | 4.94 | CHEMBL | |||||
Bile salt export pump | Transporter | IC50 | 4.76 | CHEMBL |
ID | Source |
---|---|
N0000167438 | NUI |
D00213 | KEGG_DRUG |
C0016875 | UMLSCUI |
CHEBI:29013 | CHEBI |
FUA | PDB_CHEM_ID |
CHEMBL374975 | ChEMBL_ID |
D005672 | MESH_DESCRIPTOR_UI |
DB02703 | DRUGBANK_ID |
10815 | IUPHAR_LIGAND_ID |
1431 | INN_ID |
59XE10C19C | UNII |
3000226 | PUBCHEM_CID |
202636 | RXNORM |
003486 | NDDF |
003488 | NDDF |
387530003 | SNOMEDCT_US |
395876005 | SNOMEDCT_US |
96015006 | SNOMEDCT_US |
CHEMBL1256987 | ChEMBL_ID |
None