Stem definition | Drug id | CAS RN |
---|---|---|
antibiotics, produced by Streptomyces strains | 1243 | 23155-02-4 |
Dose | Unit | Route |
---|---|---|
3 | g | O |
8 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 50 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 82 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 192.90 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 31 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.32 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 2 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 1 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 1.90 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 19, 1996 | FDA | ZAMBON SPA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Cardiospasm | 226.80 | 26.54 | 51 | 7323 | 1856 | 63479792 |
Palmoplantar keratoderma | 224.20 | 26.54 | 51 | 7323 | 1956 | 63479692 |
Pruritus genital | 210.03 | 26.54 | 51 | 7323 | 2603 | 63479045 |
Sleep terror | 209.53 | 26.54 | 51 | 7323 | 2629 | 63479019 |
Atrial tachycardia | 190.97 | 26.54 | 52 | 7322 | 4188 | 63477460 |
Carotid artery occlusion | 181.18 | 26.54 | 51 | 7323 | 4643 | 63477005 |
Tension headache | 176.15 | 26.54 | 51 | 7323 | 5135 | 63476513 |
Anosmia | 170.45 | 26.54 | 53 | 7321 | 6807 | 63474841 |
Facial pain | 148.01 | 26.54 | 53 | 7321 | 10508 | 63471140 |
Immunisation | 136.93 | 26.54 | 31 | 7343 | 1162 | 63480486 |
Pain of skin | 135.69 | 26.54 | 51 | 7323 | 11583 | 63470065 |
Subarachnoid haemorrhage | 125.53 | 26.54 | 51 | 7323 | 14232 | 63467416 |
Ventricular tachycardia | 115.31 | 26.54 | 53 | 7321 | 19926 | 63461722 |
Vasculitis | 113.60 | 26.54 | 51 | 7323 | 18158 | 63463490 |
Eye pruritus | 112.38 | 26.54 | 51 | 7323 | 18620 | 63463028 |
Muscle twitching | 109.84 | 26.54 | 51 | 7323 | 19617 | 63462031 |
Blindness | 108.09 | 26.54 | 52 | 7322 | 21647 | 63460001 |
Diplopia | 100.74 | 26.54 | 51 | 7323 | 23677 | 63457971 |
Lip swelling | 95.90 | 26.54 | 54 | 7320 | 31009 | 63450639 |
Hallucination | 87.98 | 26.54 | 63 | 7311 | 54754 | 63426894 |
Transient ischaemic attack | 83.63 | 26.54 | 53 | 7321 | 37700 | 63443948 |
Tinnitus | 78.87 | 26.54 | 50 | 7324 | 35578 | 63446070 |
Disturbance in attention | 78.13 | 26.54 | 51 | 7323 | 38138 | 63443510 |
Angioedema | 72.12 | 26.54 | 53 | 7321 | 47912 | 63433736 |
Dry skin | 70.46 | 26.54 | 56 | 7318 | 56831 | 63424817 |
Rash papular | 67.36 | 26.54 | 34 | 7340 | 15668 | 63465980 |
Cognitive disorder | 67.11 | 26.54 | 54 | 7320 | 55761 | 63425887 |
Amnesia | 65.18 | 26.54 | 53 | 7321 | 55532 | 63426116 |
Intentional product misuse | 60.94 | 26.54 | 53 | 7321 | 60864 | 63420784 |
Heart rate increased | 54.91 | 26.54 | 61 | 7313 | 94177 | 63387471 |
COVID-19 | 52.25 | 26.54 | 65 | 7309 | 113038 | 63368610 |
Tachycardia | 51.57 | 26.54 | 66 | 7308 | 118090 | 63363558 |
Migraine | 48.71 | 26.54 | 60 | 7314 | 103286 | 63378362 |
Blood glucose increased | 48.42 | 26.54 | 54 | 7320 | 83702 | 63397946 |
Feeling abnormal | 48.38 | 26.54 | 72 | 7302 | 148320 | 63333328 |
Drug reaction with eosinophilia and systemic symptoms | 47.74 | 26.54 | 36 | 7338 | 33800 | 63447848 |
Visual impairment | 44.67 | 26.54 | 52 | 7322 | 84394 | 63397254 |
Dehydration | 42.65 | 26.54 | 74 | 7300 | 173280 | 63308368 |
Hyperhidrosis | 42.03 | 26.54 | 57 | 7317 | 107779 | 63373869 |
Myocardial infarction | 39.23 | 26.54 | 53 | 7321 | 99840 | 63381808 |
Palpitations | 38.59 | 26.54 | 56 | 7318 | 112714 | 63368934 |
Muscular weakness | 37.92 | 26.54 | 58 | 7316 | 122295 | 63359353 |
Memory impairment | 34.54 | 26.54 | 51 | 7323 | 104207 | 63377441 |
Pericarditis | 33.43 | 26.54 | 57 | 7317 | 131522 | 63350126 |
Stevens-Johnson syndrome | 29.67 | 26.54 | 24 | 7350 | 24926 | 63456722 |
Respiratory alkalosis | 28.45 | 26.54 | 11 | 7363 | 2690 | 63478958 |
Malaise | 28.26 | 26.54 | 109 | 7265 | 415845 | 63065803 |
Pruritus | 28.14 | 26.54 | 99 | 7275 | 361354 | 63120294 |
Umbilical cord around neck | 27.32 | 26.54 | 6 | 7368 | 195 | 63481453 |
Mechanical urticaria | 26.95 | 26.54 | 7 | 7367 | 469 | 63481179 |
Anxiety | 26.73 | 26.54 | 70 | 7304 | 217471 | 63264177 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Cardiospasm | 295.85 | 54.53 | 66 | 6034 | 1522 | 34949309 |
Palmoplantar keratoderma | 276.99 | 54.53 | 65 | 6035 | 1888 | 34948943 |
Pruritus genital | 264.04 | 54.53 | 64 | 6036 | 2140 | 34948691 |
Sleep terror | 260.83 | 54.53 | 64 | 6036 | 2254 | 34948577 |
Tension headache | 248.37 | 54.53 | 65 | 6035 | 2977 | 34947854 |
Atrial tachycardia | 241.37 | 54.53 | 66 | 6034 | 3579 | 34947252 |
Facial pain | 235.69 | 54.53 | 65 | 6035 | 3639 | 34947192 |
Carotid artery occlusion | 235.12 | 54.53 | 65 | 6035 | 3672 | 34947159 |
Anosmia | 234.91 | 54.53 | 66 | 6034 | 3958 | 34946873 |
Immunisation | 201.88 | 54.53 | 45 | 6055 | 1032 | 34949799 |
Pain of skin | 199.47 | 54.53 | 64 | 6036 | 6045 | 34944786 |
Eye pruritus | 198.45 | 54.53 | 67 | 6033 | 7422 | 34943409 |
Pericarditis | 169.59 | 54.53 | 67 | 6033 | 11578 | 34939253 |
Vasculitis | 168.04 | 54.53 | 66 | 6034 | 11230 | 34939601 |
Muscle twitching | 166.77 | 54.53 | 64 | 6036 | 10234 | 34940597 |
Lip swelling | 164.83 | 54.53 | 72 | 6028 | 16008 | 34934823 |
Subarachnoid haemorrhage | 160.87 | 54.53 | 66 | 6034 | 12569 | 34938262 |
Blindness | 146.79 | 54.53 | 65 | 6035 | 14921 | 34935910 |
Migraine | 140.30 | 54.53 | 66 | 6034 | 17412 | 34933419 |
Diplopia | 136.42 | 54.53 | 64 | 6036 | 16779 | 34934052 |
Tinnitus | 128.53 | 54.53 | 65 | 6035 | 20053 | 34930778 |
Rash papular | 128.47 | 54.53 | 53 | 6047 | 10225 | 34940606 |
Disturbance in attention | 126.56 | 54.53 | 70 | 6030 | 25875 | 34924956 |
Pathogen resistance | 125.70 | 54.53 | 51 | 6049 | 9431 | 34941400 |
Dry skin | 119.53 | 54.53 | 72 | 6028 | 31215 | 34919616 |
Amnesia | 114.24 | 54.53 | 66 | 6034 | 26497 | 34924334 |
Alopecia | 114.11 | 54.53 | 64 | 6036 | 24291 | 34926540 |
Ventricular tachycardia | 111.54 | 54.53 | 65 | 6035 | 26514 | 34924317 |
Transient ischaemic attack | 109.24 | 54.53 | 65 | 6035 | 27548 | 34923283 |
Cognitive disorder | 106.94 | 54.53 | 65 | 6035 | 28628 | 34922203 |
Visual impairment | 100.90 | 54.53 | 68 | 6032 | 35734 | 34915097 |
Angioedema | 93.57 | 54.53 | 66 | 6034 | 37308 | 34913523 |
Palpitations | 89.56 | 54.53 | 66 | 6034 | 39920 | 34910911 |
Memory impairment | 82.69 | 54.53 | 65 | 6035 | 43253 | 34907578 |
Intentional product misuse | 79.73 | 54.53 | 65 | 6035 | 45546 | 34905285 |
Hallucination | 76.87 | 54.53 | 67 | 6033 | 51431 | 34899400 |
Heart rate increased | 76.74 | 54.53 | 64 | 6036 | 46279 | 34904552 |
COVID-19 | 67.27 | 54.53 | 75 | 6025 | 77475 | 34873356 |
Abdominal discomfort | 64.55 | 54.53 | 65 | 6035 | 59770 | 34891061 |
Feeling abnormal | 63.33 | 54.53 | 66 | 6034 | 63169 | 34887662 |
Blood glucose increased | 58.66 | 54.53 | 65 | 6035 | 66653 | 34884178 |
Muscular weakness | 57.28 | 54.53 | 67 | 6033 | 72830 | 34878001 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Cardiospasm | 501.39 | 28.82 | 114 | 12461 | 3187 | 79728626 |
Palmoplantar keratoderma | 482.68 | 28.82 | 113 | 12462 | 3603 | 79728210 |
Sleep terror | 457.14 | 28.82 | 112 | 12463 | 4346 | 79727467 |
Pruritus genital | 456.44 | 28.82 | 112 | 12463 | 4374 | 79727439 |
Atrial tachycardia | 418.78 | 28.82 | 115 | 12460 | 7018 | 79724795 |
Tension headache | 408.31 | 28.82 | 113 | 12462 | 7098 | 79724715 |
Carotid artery occlusion | 401.75 | 28.82 | 113 | 12462 | 7534 | 79724279 |
Anosmia | 398.75 | 28.82 | 116 | 12459 | 8728 | 79723085 |
Facial pain | 356.47 | 28.82 | 115 | 12460 | 12235 | 79719578 |
Pain of skin | 325.76 | 28.82 | 112 | 12463 | 14501 | 79717312 |
Immunisation | 324.52 | 28.82 | 74 | 12501 | 2093 | 79729720 |
Eye pruritus | 299.09 | 28.82 | 115 | 12460 | 20455 | 79711358 |
Subarachnoid haemorrhage | 276.35 | 28.82 | 114 | 12461 | 24351 | 79707462 |
Vasculitis | 273.52 | 28.82 | 114 | 12461 | 24988 | 79706825 |
Muscle twitching | 268.27 | 28.82 | 112 | 12463 | 24652 | 79707161 |
Blindness | 260.03 | 28.82 | 114 | 12461 | 28269 | 79703544 |
Lip swelling | 243.63 | 28.82 | 122 | 12453 | 40789 | 79691024 |
Diplopia | 235.90 | 28.82 | 112 | 12463 | 33354 | 79698459 |
Ventricular tachycardia | 220.51 | 28.82 | 115 | 12460 | 41820 | 79689993 |
Tinnitus | 206.11 | 28.82 | 112 | 12463 | 44221 | 79687592 |
Disturbance in attention | 205.21 | 28.82 | 117 | 12458 | 50684 | 79681129 |
Transient ischaemic attack | 195.93 | 28.82 | 115 | 12460 | 52580 | 79679233 |
Dry skin | 190.78 | 28.82 | 124 | 12451 | 67871 | 79663942 |
Rash papular | 181.37 | 28.82 | 82 | 12493 | 21834 | 79709979 |
Amnesia | 179.37 | 28.82 | 116 | 12459 | 62941 | 79668872 |
Hallucination | 169.26 | 28.82 | 126 | 12449 | 85619 | 79646194 |
Cognitive disorder | 168.45 | 28.82 | 116 | 12459 | 69810 | 79662003 |
Angioedema | 157.41 | 28.82 | 115 | 12460 | 75920 | 79655893 |
Migraine | 155.99 | 28.82 | 121 | 12454 | 87372 | 79644441 |
Visual impairment | 139.93 | 28.82 | 116 | 12459 | 92015 | 79639798 |
Pericarditis | 137.42 | 28.82 | 121 | 12454 | 104115 | 79627698 |
Intentional product misuse | 134.60 | 28.82 | 115 | 12460 | 95050 | 79636763 |
Pathogen resistance | 126.10 | 28.82 | 56 | 12519 | 14286 | 79717527 |
Heart rate increased | 124.09 | 28.82 | 122 | 12453 | 120602 | 79611211 |
COVID-19 | 120.45 | 28.82 | 136 | 12439 | 157538 | 79574275 |
Blood glucose increased | 117.81 | 28.82 | 116 | 12459 | 114859 | 79616954 |
Memory impairment | 114.98 | 28.82 | 113 | 12462 | 111621 | 79620192 |
Palpitations | 112.00 | 28.82 | 118 | 12457 | 126492 | 79605321 |
Feeling abnormal | 104.41 | 28.82 | 127 | 12448 | 159072 | 79572741 |
Tachycardia | 97.89 | 28.82 | 130 | 12445 | 177638 | 79554175 |
Muscular weakness | 95.43 | 28.82 | 122 | 12453 | 160607 | 79571206 |
Hyperhidrosis | 88.37 | 28.82 | 114 | 12461 | 151378 | 79580435 |
Myocardial infarction | 75.40 | 28.82 | 117 | 12458 | 184012 | 79547801 |
Dehydration | 67.96 | 28.82 | 132 | 12443 | 248055 | 79483758 |
Drug resistance | 63.70 | 28.82 | 53 | 12522 | 42160 | 79689653 |
Alopecia | 60.84 | 28.82 | 121 | 12454 | 231234 | 79500579 |
Chest pain | 59.61 | 28.82 | 135 | 12440 | 282169 | 79449644 |
Insomnia | 58.30 | 28.82 | 123 | 12452 | 245047 | 79486766 |
Abdominal pain upper | 57.58 | 28.82 | 116 | 12459 | 223703 | 79508110 |
Anxiety | 57.16 | 28.82 | 123 | 12452 | 248389 | 79483424 |
Pruritus | 53.70 | 28.82 | 160 | 12415 | 394488 | 79337325 |
Intentional product use issue | 53.17 | 28.82 | 90 | 12485 | 152022 | 79579791 |
Peripheral swelling | 51.51 | 28.82 | 124 | 12451 | 269493 | 79462320 |
Back pain | 50.90 | 28.82 | 133 | 12442 | 304047 | 79427766 |
Abdominal discomfort | 50.81 | 28.82 | 118 | 12457 | 250609 | 79481204 |
Malaise | 49.09 | 28.82 | 179 | 12396 | 489690 | 79242123 |
Death | 41.12 | 28.82 | 19 | 12556 | 566495 | 79165318 |
Adverse drug reaction | 38.71 | 28.82 | 50 | 12525 | 66342 | 79665471 |
Toxicity to various agents | 32.37 | 28.82 | 13 | 12562 | 421527 | 79310286 |
Conductive deafness | 29.44 | 28.82 | 7 | 12568 | 238 | 79731575 |
Drug hypersensitivity | 28.84 | 28.82 | 6 | 12569 | 298910 | 79432903 |
None
Source | Code | Description |
---|---|---|
ATC | J01XX01 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER ANTIBACTERIALS Other antibacterials |
ATC | S02AA17 | SENSORY ORGANS OTOLOGICALS ANTIINFECTIVES Antiinfectives |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
CHEBI has role | CHEBI:33281 | antibiotics |
CHEBI has role | CHEBI:78379 | EC 2.5.1.7 inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Urinary tract infectious disease | indication | 68566005 | |
Escherichia coli urinary tract infection | indication | 301011002 | |
Enterococcus Urinary Tract Infection | indication | ||
Kidney disease | contraindication | 90708001 | DOID:557 |
Pseudomembranous enterocolitis | contraindication | 397683000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 0.54 | acidic |
pKa2 | 5.59 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
UDP-N-acetylglucosamine 1-carboxyvinyltransferase | Enzyme | INHIBITOR | IC50 | 7 | CHEMBL | CHEMBL | |||
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1 | Enzyme | WOMBAT-PK | |||||||
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2 | Enzyme | WOMBAT-PK | |||||||
UDP-N-acetylglucosamine 1-carboxyvinyltransferase | Enzyme | IC50 | 4.98 | CHEMBL |
ID | Source |
---|---|
4024047 | VUID |
N0000022052 | NUI |
D00925 | KEGG_DRUG |
78964-85-9 | SECONDARY_CAS_RN |
4021007 | VANDF |
4024047 | VANDF |
C0016610 | UMLSCUI |
CHEBI:62419 | CHEBI |
FCN | PDB_CHEM_ID |
CHEMBL1757 | ChEMBL_ID |
DB00828 | DRUGBANK_ID |
CHEMBL1200331 | ChEMBL_ID |
D005578 | MESH_DESCRIPTOR_UI |
446987 | PUBCHEM_CID |
3014 | INN_ID |
10813 | IUPHAR_LIGAND_ID |
2N81MY12TE | UNII |
142135 | RXNORM |
29490 | MMSL |
340066 | MMSL |
4765 | MMSL |
d04106 | MMSL |
004467 | NDDF |
004468 | NDDF |
108720006 | SNOMEDCT_US |
108721005 | SNOMEDCT_US |
372534005 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Monurol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0456-4300 | POWDER | 3 g | ORAL | NDA | 23 sections |
Monurol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0456-4300 | POWDER | 3 g | ORAL | NDA | 23 sections |
FOSFOMYCIN TROMETHAMINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-5826 | POWDER | 3 g | ORAL | ANDA | 20 sections |
FOSFOMYCIN TROMETHAMINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-5826 | POWDER | 3 g | ORAL | ANDA | 20 sections |
Fosfomycin Tromethamine | Human Prescription Drug Label | 1 | 50090-6130 | GRANULE, FOR SOLUTION | 3 g | ORAL | ANDA | 21 sections |
Fosfomycin Tromethamine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-9470 | GRANULE, FOR SOLUTION | 3 g | ORAL | ANDA | 21 sections |
Fosfomycin Tromethamine | Human Prescription Drug Label | 1 | 67877-749 | GRANULE, FOR SOLUTION | 3 g | ORAL | ANDA | 21 sections |
Fosfomycin Tromethamine | Human Prescription Drug Label | 1 | 67877-749 | GRANULE, FOR SOLUTION | 3 g | ORAL | ANDA | 21 sections |
FOSFOMYCIN TROMETHAMINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 69097-579 | GRANULE, FOR SOLUTION | 3 g | ORAL | ANDA | 18 sections |
FOSFOMYCIN TROMETHAMINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70700-268 | POWDER | 3 g | ORAL | ANDA | 20 sections |
FOSFOMYCIN TROMETHAMINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70700-268 | POWDER | 3 g | ORAL | ANDA | 20 sections |
Fosfomycin Tromethamine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 82036-4274 | POWDER | 3 g | ORAL | NDA authorized generic | 22 sections |
Fosfomycin Tromethamine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 82036-4274 | POWDER | 3 g | ORAL | NDA authorized generic | 22 sections |