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| Stem definition | Drug id | CAS RN |
|---|---|---|
| insecticides, anthelminthics, pesticides etc., phosphorous derivatives | 1241 | 4428-95-9 |
| Dose | Unit | Route |
|---|---|---|
| 6.50 | g | P |
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 82 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 952.34 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 9 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.50 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 2.10 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.85 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 4.70 hours | Lombardo F, Berellini G, Obach RS |
| S (Water solubility) | 24 mg/mL | Bocci G, Oprea TI, Benet LZ |
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT1,FLT3,GRK2,GSK3B,ITK,JAK1,JAK2,JAK3,KDR,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK7,MAPK9,MAPKAPK2,MTOR,NTRK1,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 | 62 | |||
| kinase-selectivity-class | ACVR2B,ACVRL1,AURKA,AURKB,AXL,BMX,BRAF,CDK4,CDK9,DDR1,DYRK1B,EPHB4,ERBB2,GRK2,IRAK3,JAK2,MAP2K6,MAP3K14,MAPK14,MAPK7,MAPK8,PIK3CB,PIK3CD,PIK3CG,PRKDC,STK33,SYK,TEK,TGFBR1,TTK,ZAP70 | 31 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
| Date | Agency | Company | Orphan |
|---|---|---|---|
| March 26, 2019 | PMDA | CLINIGEN K.K. | |
| Sept. 27, 1991 | FDA | CLINIGEN HLTHCARE |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug resistance | 617.86 | 45.43 | 175 | 5585 | 30274 | 90592413 |
| Pathogen resistance | 470.70 | 45.43 | 108 | 5652 | 8007 | 90614680 |
| Encephalitis cytomegalovirus | 279.03 | 45.43 | 47 | 5713 | 675 | 90622012 |
| Cytomegalovirus infection | 278.09 | 45.43 | 92 | 5668 | 26510 | 90596177 |
| Cytomegalovirus viraemia | 259.52 | 45.43 | 66 | 5694 | 7520 | 90615167 |
| Nephropathy toxic | 252.66 | 45.43 | 72 | 5688 | 12616 | 90610071 |
| Off label use | 202.21 | 45.43 | 294 | 5466 | 1101958 | 89520729 |
| Viral haemorrhagic cystitis | 172.07 | 45.43 | 35 | 5725 | 1458 | 90621229 |
| Renal impairment | 153.72 | 45.43 | 91 | 5669 | 105330 | 90517357 |
| Transplant dysfunction | 151.69 | 45.43 | 40 | 5720 | 5242 | 90617445 |
| Cytomegalovirus infection reactivation | 136.26 | 45.43 | 40 | 5720 | 7760 | 90614927 |
| Multiple organ dysfunction syndrome | 134.92 | 45.43 | 72 | 5688 | 68264 | 90554423 |
| Graft versus host disease in gastrointestinal tract | 120.13 | 45.43 | 32 | 5728 | 4356 | 90618331 |
| BK virus infection | 109.97 | 45.43 | 30 | 5730 | 4468 | 90618219 |
| Pancytopenia | 104.31 | 45.43 | 75 | 5685 | 120188 | 90502499 |
| Graft versus host disease | 100.58 | 45.43 | 32 | 5728 | 8112 | 90614575 |
| Chronic graft versus host disease | 98.37 | 45.43 | 27 | 5733 | 4112 | 90618575 |
| Pneumonia cytomegaloviral | 96.25 | 45.43 | 25 | 5735 | 3086 | 90619601 |
| Acute graft versus host disease | 95.31 | 45.43 | 28 | 5732 | 5440 | 90617247 |
| Cystitis haemorrhagic | 95.08 | 45.43 | 28 | 5732 | 5485 | 90617202 |
| Cytomegalovirus gastrointestinal infection | 92.89 | 45.43 | 17 | 5743 | 401 | 90622286 |
| Venoocclusive liver disease | 92.78 | 45.43 | 28 | 5732 | 5965 | 90616722 |
| Retinitis viral | 92.03 | 45.43 | 16 | 5744 | 279 | 90622408 |
| Haemophagocytic lymphohistiocytosis | 91.14 | 45.43 | 35 | 5725 | 15424 | 90607263 |
| Neutropenia | 84.88 | 45.43 | 87 | 5673 | 224817 | 90397870 |
| Hypouricaemia | 80.21 | 45.43 | 14 | 5746 | 250 | 90622437 |
| Adenoviral hepatitis | 78.92 | 45.43 | 15 | 5745 | 437 | 90622250 |
| Cytomegalovirus chorioretinitis | 77.55 | 45.43 | 20 | 5740 | 2399 | 90620288 |
| Epstein-Barr virus infection reactivation | 74.89 | 45.43 | 18 | 5742 | 1619 | 90621068 |
| Human herpesvirus 6 infection | 70.62 | 45.43 | 20 | 5740 | 3412 | 90619275 |
| Acute kidney injury | 70.62 | 45.43 | 94 | 5666 | 320293 | 90302394 |
| Adenovirus infection | 68.99 | 45.43 | 21 | 5739 | 4601 | 90618086 |
| Cytomegalovirus colitis | 66.38 | 45.43 | 19 | 5741 | 3367 | 90619320 |
| Acidosis hyperchloraemic | 62.99 | 45.43 | 14 | 5746 | 892 | 90621795 |
| Myelosuppression | 59.60 | 45.43 | 39 | 5721 | 53552 | 90569135 |
| Renal tubular injury | 58.51 | 45.43 | 14 | 5746 | 1235 | 90621452 |
| Bladder hypertrophy | 58.44 | 45.43 | 12 | 5748 | 523 | 90622164 |
| Infection reactivation | 57.16 | 45.43 | 15 | 5745 | 1925 | 90620762 |
| Cerebral toxoplasmosis | 56.87 | 45.43 | 14 | 5746 | 1391 | 90621296 |
| Respiratory failure | 56.21 | 45.43 | 52 | 5708 | 118366 | 90504321 |
| Graft versus host disease in skin | 55.35 | 45.43 | 17 | 5743 | 3836 | 90618851 |
| Hepatic failure | 54.43 | 45.43 | 33 | 5727 | 39695 | 90582992 |
| Fatigue | 52.72 | 45.43 | 6 | 5754 | 1154017 | 89468670 |
| Cytomegalovirus enterocolitis | 52.57 | 45.43 | 12 | 5748 | 862 | 90621825 |
| Hypomagnesaemia | 52.49 | 45.43 | 31 | 5729 | 35557 | 90587130 |
| Nephrogenic diabetes insipidus | 51.33 | 45.43 | 12 | 5748 | 958 | 90621729 |
| Thrombotic microangiopathy | 50.15 | 45.43 | 23 | 5737 | 15720 | 90606967 |
| Staphylococcal sepsis | 47.39 | 45.43 | 19 | 5741 | 9364 | 90613323 |
| Bronchopulmonary aspergillosis | 47.12 | 45.43 | 20 | 5740 | 11378 | 90611309 |
| Disseminated intravascular coagulation | 46.15 | 45.43 | 24 | 5736 | 21514 | 90601173 |
| Venous haemorrhage | 46.12 | 45.43 | 9 | 5751 | 302 | 90622385 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug resistance | 605.56 | 32.38 | 224 | 6930 | 34024 | 42580157 |
| Nephropathy toxic | 307.47 | 32.38 | 113 | 7041 | 16725 | 42597456 |
| Cytomegalovirus viraemia | 267.33 | 32.38 | 90 | 7064 | 10287 | 42603894 |
| Cystitis haemorrhagic | 255.66 | 32.38 | 80 | 7074 | 7249 | 42606932 |
| Pathogen resistance | 250.96 | 32.38 | 88 | 7066 | 11362 | 42602819 |
| Cytomegalovirus infection reactivation | 241.50 | 32.38 | 85 | 7069 | 11093 | 42603088 |
| Off label use | 228.10 | 32.38 | 391 | 6763 | 637944 | 41976237 |
| BK virus infection | 205.90 | 32.38 | 71 | 7083 | 8713 | 42605468 |
| Epstein-Barr viraemia | 203.78 | 32.38 | 52 | 7102 | 2237 | 42611944 |
| Pancytopenia | 195.77 | 32.38 | 160 | 6994 | 117583 | 42496598 |
| Myelosuppression | 179.06 | 32.38 | 101 | 7053 | 40360 | 42573821 |
| Encephalitis cytomegalovirus | 175.97 | 32.38 | 41 | 7113 | 1198 | 42612983 |
| Pneumonia cytomegaloviral | 156.30 | 32.38 | 48 | 7106 | 4078 | 42610103 |
| Drug ineffective | 156.01 | 32.38 | 331 | 6823 | 629866 | 41984315 |
| Cytomegalovirus chorioretinitis | 134.68 | 32.38 | 44 | 7110 | 4567 | 42609614 |
| Cytomegalovirus infection | 133.08 | 32.38 | 77 | 7077 | 32229 | 42581952 |
| Generalised oedema | 122.34 | 32.38 | 57 | 7097 | 15279 | 42598902 |
| Acute kidney injury | 106.86 | 32.38 | 207 | 6947 | 367130 | 42247051 |
| Acute graft versus host disease in skin | 103.59 | 32.38 | 41 | 7113 | 7383 | 42606798 |
| Renal impairment | 103.39 | 32.38 | 109 | 7045 | 110119 | 42504062 |
| Respiratory distress | 100.60 | 32.38 | 71 | 7083 | 41749 | 42572432 |
| Retinal detachment | 67.16 | 32.38 | 29 | 7125 | 6496 | 42607685 |
| Acute graft versus host disease | 63.83 | 32.38 | 30 | 7124 | 8185 | 42605996 |
| Necrotising retinitis | 61.19 | 32.38 | 17 | 7137 | 1013 | 42613168 |
| Aplastic anaemia | 60.38 | 32.38 | 33 | 7121 | 12351 | 42601830 |
| Multiple organ dysfunction syndrome | 59.16 | 32.38 | 77 | 7077 | 96958 | 42517223 |
| Graft versus host disease | 59.06 | 32.38 | 33 | 7121 | 12892 | 42601289 |
| Renal tubular disorder | 57.78 | 32.38 | 24 | 7130 | 4885 | 42609296 |
| Thrombotic microangiopathy | 57.55 | 32.38 | 34 | 7120 | 14748 | 42599433 |
| Lung disorder | 57.01 | 32.38 | 54 | 7100 | 47869 | 42566312 |
| Product use issue | 56.56 | 32.38 | 67 | 7087 | 76684 | 42537497 |
| Acute graft versus host disease in intestine | 52.25 | 32.38 | 21 | 7133 | 3930 | 42610251 |
| Botulism | 51.61 | 32.38 | 11 | 7143 | 211 | 42613970 |
| Retinal scar | 50.89 | 32.38 | 12 | 7142 | 369 | 42613812 |
| Encephalitis | 46.30 | 32.38 | 25 | 7129 | 9133 | 42605048 |
| Graft versus host disease in gastrointestinal tract | 43.74 | 32.38 | 20 | 7134 | 5123 | 42609058 |
| Disseminated cytomegaloviral infection | 43.48 | 32.38 | 10 | 7144 | 275 | 42613906 |
| Drug ineffective for unapproved indication | 42.01 | 32.38 | 45 | 7109 | 46118 | 42568063 |
| Cytomegalovirus colitis | 41.97 | 32.38 | 18 | 7136 | 3963 | 42610218 |
| Fatigue | 39.70 | 32.38 | 12 | 7142 | 435629 | 42178552 |
| Haemophagocytic lymphohistiocytosis | 39.34 | 32.38 | 29 | 7125 | 18193 | 42595988 |
| Lymphopenia | 35.01 | 32.38 | 29 | 7125 | 21534 | 42592647 |
| Glomerulonephropathy | 34.41 | 32.38 | 8 | 7146 | 231 | 42613950 |
| Cytomegalovirus test positive | 34.25 | 32.38 | 16 | 7138 | 4303 | 42609878 |
| Meningitis viral | 34.10 | 32.38 | 11 | 7143 | 1094 | 42613087 |
| Aspergillus infection | 33.72 | 32.38 | 25 | 7129 | 15812 | 42598369 |
| Hypokalaemia | 33.34 | 32.38 | 50 | 7104 | 71671 | 42542510 |
| Bone marrow failure | 33.21 | 32.38 | 34 | 7120 | 33059 | 42581122 |
| Bacterial toxaemia | 32.56 | 32.38 | 7 | 7147 | 140 | 42614041 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug resistance | 1325.06 | 33.50 | 414 | 12148 | 55960 | 110520777 |
| Pathogen resistance | 682.53 | 33.50 | 191 | 12371 | 17481 | 110559256 |
| Nephropathy toxic | 570.54 | 33.50 | 184 | 12378 | 27294 | 110549443 |
| Cytomegalovirus viraemia | 473.39 | 33.50 | 144 | 12418 | 17620 | 110559117 |
| Off label use | 433.56 | 33.50 | 674 | 11888 | 1499511 | 109077226 |
| Encephalitis cytomegalovirus | 405.13 | 33.50 | 82 | 12480 | 1828 | 110574909 |
| Cytomegalovirus infection reactivation | 401.88 | 33.50 | 128 | 12434 | 18205 | 110558532 |
| Cytomegalovirus infection | 377.46 | 33.50 | 163 | 12399 | 54281 | 110522456 |
| BK virus infection | 331.05 | 33.50 | 102 | 12460 | 13004 | 110563733 |
| Cystitis haemorrhagic | 325.31 | 33.50 | 99 | 12463 | 12110 | 110564627 |
| Pancytopenia | 296.77 | 33.50 | 221 | 12341 | 209392 | 110367345 |
| Renal impairment | 254.00 | 33.50 | 193 | 12369 | 188252 | 110388485 |
| Myelosuppression | 236.34 | 33.50 | 142 | 12420 | 94198 | 110482539 |
| Pneumonia cytomegaloviral | 218.21 | 33.50 | 64 | 12498 | 6890 | 110569847 |
| Epstein-Barr viraemia | 210.53 | 33.50 | 54 | 12508 | 3525 | 110573212 |
| Drug ineffective | 204.21 | 33.50 | 496 | 12066 | 1520044 | 109056693 |
| Cytomegalovirus chorioretinitis | 194.98 | 33.50 | 59 | 12503 | 7069 | 110569668 |
| Acute kidney injury | 190.22 | 33.50 | 292 | 12270 | 635138 | 109941599 |
| Viral haemorrhagic cystitis | 155.41 | 33.50 | 42 | 12520 | 3357 | 110573380 |
| Graft versus host disease | 152.48 | 33.50 | 63 | 12499 | 18743 | 110557994 |
| Multiple organ dysfunction syndrome | 152.47 | 33.50 | 131 | 12431 | 151579 | 110425158 |
| Graft versus host disease in gastrointestinal tract | 149.70 | 33.50 | 51 | 12511 | 8917 | 110567820 |
| Transplant dysfunction | 149.42 | 33.50 | 50 | 12512 | 8278 | 110568459 |
| Acute graft versus host disease | 138.82 | 33.50 | 53 | 12509 | 12828 | 110563909 |
| Generalised oedema | 125.85 | 33.50 | 64 | 12498 | 30640 | 110546097 |
| Respiratory distress | 118.71 | 33.50 | 82 | 12480 | 68792 | 110507945 |
| Chronic graft versus host disease | 109.46 | 33.50 | 41 | 12521 | 9416 | 110567321 |
| Acute graft versus host disease in skin | 107.92 | 33.50 | 42 | 12520 | 10698 | 110566039 |
| Cytomegalovirus colitis | 101.80 | 33.50 | 36 | 12526 | 7025 | 110569712 |
| Aplastic anaemia | 100.58 | 33.50 | 51 | 12511 | 24257 | 110552480 |
| Renal tubular disorder | 100.01 | 33.50 | 36 | 12526 | 7393 | 110569344 |
| Haemophagocytic lymphohistiocytosis | 98.87 | 33.50 | 55 | 12507 | 31504 | 110545233 |
| Thrombotic microangiopathy | 97.38 | 33.50 | 53 | 12509 | 29096 | 110547641 |
| Human herpesvirus 6 infection | 92.78 | 33.50 | 33 | 12529 | 6548 | 110570189 |
| Fatigue | 92.69 | 33.50 | 14 | 12548 | 1215944 | 109360793 |
| Adenovirus infection | 89.68 | 33.50 | 37 | 12525 | 10957 | 110565780 |
| Epstein-Barr virus infection reactivation | 83.22 | 33.50 | 27 | 12535 | 4057 | 110572680 |
| Retinitis viral | 81.44 | 33.50 | 17 | 12545 | 442 | 110576295 |
| Arthralgia | 75.70 | 33.50 | 3 | 12559 | 779629 | 109797108 |
| Acute graft versus host disease in intestine | 74.68 | 33.50 | 27 | 12535 | 5612 | 110571125 |
| Adenoviral hepatitis | 73.09 | 33.50 | 18 | 12544 | 994 | 110575743 |
| Retinal detachment | 72.79 | 33.50 | 32 | 12530 | 11068 | 110565669 |
| Necrotising retinitis | 69.59 | 33.50 | 19 | 12543 | 1577 | 110575160 |
| Cytomegalovirus gastritis | 69.24 | 33.50 | 16 | 12546 | 672 | 110576065 |
| Neutropenia | 64.92 | 33.50 | 136 | 12426 | 374484 | 110202253 |
| Drug ineffective for unapproved indication | 63.59 | 33.50 | 68 | 12494 | 102770 | 110473967 |
| Venoocclusive liver disease | 63.18 | 33.50 | 32 | 12530 | 15175 | 110561562 |
| Epstein-Barr virus infection | 62.38 | 33.50 | 34 | 12528 | 18704 | 110558033 |
| Hypomagnesaemia | 62.33 | 33.50 | 53 | 12509 | 60317 | 110516420 |
| Bone marrow failure | 62.22 | 33.50 | 52 | 12510 | 57796 | 110518941 |
| Hypouricaemia | 61.15 | 33.50 | 14 | 12548 | 564 | 110576173 |
| Post transplant lymphoproliferative disorder | 59.50 | 33.50 | 31 | 12531 | 15582 | 110561155 |
| Dyspnoea | 57.59 | 33.50 | 27 | 12535 | 1106845 | 109469892 |
| Human herpesvirus 6 encephalitis | 57.31 | 33.50 | 15 | 12547 | 1059 | 110575678 |
| Respiratory failure | 57.20 | 33.50 | 94 | 12468 | 215238 | 110361499 |
| Cytomegalovirus test positive | 55.09 | 33.50 | 23 | 12539 | 7013 | 110569724 |
| Aspergillus infection | 55.01 | 33.50 | 35 | 12527 | 25581 | 110551156 |
| Bronchopulmonary aspergillosis | 54.85 | 33.50 | 37 | 12525 | 29826 | 110546911 |
| Cytopenia | 52.19 | 33.50 | 36 | 12526 | 30080 | 110546657 |
| Graft versus host disease in skin | 51.56 | 33.50 | 23 | 12539 | 8231 | 110568506 |
| Product use issue | 51.47 | 33.50 | 111 | 12451 | 311584 | 110265153 |
| Lymphopenia | 51.45 | 33.50 | 40 | 12522 | 40130 | 110536607 |
| Dizziness | 50.92 | 33.50 | 9 | 12553 | 698184 | 109878553 |
| Malaise | 50.46 | 33.50 | 8 | 12554 | 671811 | 109904926 |
| Pain | 50.09 | 33.50 | 23 | 12539 | 954932 | 109621805 |
| Mucosal inflammation | 49.86 | 33.50 | 58 | 12504 | 96083 | 110480654 |
| Disseminated cytomegaloviral infection | 49.58 | 33.50 | 12 | 12550 | 616 | 110576121 |
| Meningitis viral | 49.45 | 33.50 | 16 | 12546 | 2383 | 110574354 |
| Meningoencephalitis herpetic | 49.43 | 33.50 | 16 | 12546 | 2386 | 110574351 |
| Cerebral toxoplasmosis | 49.05 | 33.50 | 17 | 12545 | 3125 | 110573612 |
| Hepatic failure | 48.87 | 33.50 | 49 | 12513 | 68690 | 110508047 |
| Encephalitis | 48.76 | 33.50 | 29 | 12533 | 18810 | 110557927 |
| Fall | 48.09 | 33.50 | 6 | 12556 | 603476 | 109973261 |
| Retinal scar | 47.46 | 33.50 | 11 | 12551 | 468 | 110576269 |
| Bladder hypertrophy | 47.24 | 33.50 | 13 | 12549 | 1111 | 110575626 |
| Hypocalcaemia | 47.22 | 33.50 | 47 | 12515 | 65319 | 110511418 |
| Acidosis hyperchloraemic | 47.13 | 33.50 | 14 | 12548 | 1572 | 110575165 |
| Disseminated intravascular coagulation | 46.24 | 33.50 | 38 | 12524 | 41248 | 110535489 |
| Botulism | 46.21 | 33.50 | 11 | 12551 | 526 | 110576211 |
| Asthenia | 45.86 | 33.50 | 11 | 12551 | 688988 | 109887749 |
| Staphylococcal sepsis | 45.52 | 33.50 | 27 | 12535 | 17427 | 110559310 |
| Genital ulceration | 44.10 | 33.50 | 14 | 12548 | 1961 | 110574776 |
| Pain in extremity | 43.70 | 33.50 | 3 | 12559 | 487115 | 110089622 |
| Cytomegalovirus gastrointestinal infection | 42.94 | 33.50 | 11 | 12551 | 713 | 110576024 |
| Renal failure | 42.43 | 33.50 | 85 | 12477 | 226489 | 110350248 |
| Nausea | 42.29 | 33.50 | 47 | 12515 | 1235643 | 109341094 |
| Septic shock | 42.12 | 33.50 | 69 | 12493 | 157459 | 110419278 |
| Cytomegalovirus enterocolitis | 42.12 | 33.50 | 14 | 12548 | 2267 | 110574470 |
| Renal tubular injury | 41.60 | 33.50 | 15 | 12547 | 3093 | 110573644 |
| Toxic epidermal necrolysis | 41.36 | 33.50 | 41 | 12521 | 56686 | 110520051 |
| Neurological decompensation | 39.25 | 33.50 | 18 | 12544 | 6865 | 110569872 |
| Venous haemorrhage | 39.18 | 33.50 | 9 | 12553 | 368 | 110576369 |
| Acute graft versus host disease in liver | 37.74 | 33.50 | 13 | 12549 | 2346 | 110574391 |
| Infection reactivation | 37.63 | 33.50 | 15 | 12547 | 4066 | 110572671 |
| Hypokalaemia | 37.25 | 33.50 | 71 | 12491 | 182377 | 110394360 |
| Electrolyte imbalance | 37.17 | 33.50 | 32 | 12530 | 36996 | 110539741 |
| Multiple-drug resistance | 35.89 | 33.50 | 21 | 12541 | 13214 | 110563523 |
| Headache | 35.47 | 33.50 | 29 | 12533 | 882348 | 109694389 |
| Pruritus | 35.46 | 33.50 | 11 | 12551 | 581549 | 109995188 |
| Drug hypersensitivity | 35.00 | 33.50 | 5 | 12557 | 454085 | 110122652 |
| Herpes simplex test positive | 34.44 | 33.50 | 9 | 12553 | 631 | 110576106 |
| Bacterial toxaemia | 34.11 | 33.50 | 7 | 12555 | 167 | 110576570 |
| Glomerulonephropathy | 34.10 | 33.50 | 8 | 12554 | 359 | 110576378 |
| Abdominal discomfort | 33.70 | 33.50 | 3 | 12559 | 393855 | 110182882 |
None
| Source | Code | Description |
|---|---|---|
| ATC | J05AD01 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Phosphonic acid derivatives |
| FDA MoA | N0000000087 | Chelating Activity |
| FDA MoA | N0000020060 | DNA Polymerase Inhibitors |
| FDA EXT | N0000175469 | Pyrophosphate Analog |
| FDA EPC | N0000175470 | Pyrophosphate Analog DNA Polymerase Inhibitor |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000998 | Antiviral Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D018894 | Reverse Transcriptase Inhibitors |
| MeSH PA | D019384 | Nucleic Acid Synthesis Inhibitors |
| CHEBI has role | CHEBI:22587 | antiviral agent |
| CHEBI has role | CHEBI:36044 | antiviral drug |
| CHEBI has role | CHEBI:53756 | HIV-1 reverse transcriptase inhibitor |
| CHEBI has role | CHEBI:63330 | sodium-dependent Pi-transporter inhibitor |
| CHEBI has role | CHEBI:176497 | geroprotector |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Encephalitis caused by human herpesvirus 6 infection | indication | 441512004 | |
| Acyclovir-Resistant Mucocutaneous HSV in Immunocompromised Patients | indication | ||
| CMV Retinitis in AIDS Patients | indication | ||
| Herpes zoster associated with AIDS | off-label use | 422127002 | |
| Acyclovir-Resistant HSV Infections | off-label use | ||
| CMV-Related Polyradiculopathy in AIDS Patients | off-label use | ||
| Prevention of Cytomegalovirus Disease | off-label use | ||
| Hypophosphatemia | contraindication | 4996001 | |
| Hypocalcemia | contraindication | 5291005 | |
| Hyperphosphatemia | contraindication | 20165001 | DOID:0050459 |
| Torsades de pointes | contraindication | 31722008 | |
| Dehydration | contraindication | 34095006 | |
| Hypokalemia | contraindication | 43339004 | |
| Epilepsy | contraindication | 84757009 | DOID:1826 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Prolonged QT interval | contraindication | 111975006 | |
| Hypomagnesemia | contraindication | 190855004 | |
| Anemia | contraindication | 271737000 | DOID:2355 |
| Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
| Granulocytopenic disorder | contraindication | 417672002 | |
| Congenital long QT syndrome | contraindication | 442917000 |
None
None
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 0.44 | acidic |
| pKa2 | 3.41 | acidic |
| pKa3 | 5.49 | acidic |
None
None
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| DNA polymerase catalytic subunit | Enzyme | INHIBITOR | IC50 | 4.13 | CHEMBL | CHEMBL | |||
| DNA polymerase catalytic subunit | Enzyme | IC50 | 5.60 | CHEMBL | |||||
| Reverse transcriptase/RNaseH | Enzyme | IC50 | 5.69 | CHEMBL | |||||
| Reverse transcriptase | Enzyme | IC50 | 5.60 | CHEMBL |
| ID | Source |
|---|---|
| D00579 | KEGG_DRUG |
| 34156-56-4 | SECONDARY_CAS_RN |
| 4020530 | VANDF |
| C0070895 | UMLSCUI |
| CHEBI:127780 | CHEBI |
| PPF | PDB_CHEM_ID |
| CHEMBL666 | ChEMBL_ID |
| 3415 | PUBCHEM_CID |
| DB00529 | DRUGBANK_ID |
| CHEMBL754 | ChEMBL_ID |
| D017245 | MESH_DESCRIPTOR_UI |
| 5497 | IUPHAR_LIGAND_ID |
| 364P9RVW4X | UNII |
| 225811 | RXNORM |
| 306 | MMSL |
| 4764 | MMSL |
| 74819 | MMSL |
| d00065 | MMSL |
| 003605 | NDDF |
| 006662 | NDDF |
| 372902006 | SNOMEDCT_US |
| 96099004 | SNOMEDCT_US |
| 96100007 | SNOMEDCT_US |
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Foscarnet Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9192 | INJECTION, SOLUTION | 24 mg | INTRAVENOUS | ANDA | 23 sections |
| foscarnet sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 23155-771 | INJECTION, SOLUTION | 24 mg | INTRAVENOUS | ANDA | 20 sections |
| Foscarnet Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-189 | INJECTION, SOLUTION | 24 mg | INTRAVENOUS | ANDA | 25 sections |
| FOSCARNET SODIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43066-089 | INJECTION, SOLUTION | 6000 mg | INTRAVENOUS | ANDA | 22 sections |
| Foscarnet | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63323-875 | INJECTION, SOLUTION | 24 mg | INTRAVENOUS | ANDA | 23 sections |
| Foscarnet Sodium | Human Prescription Drug Label | 1 | 65145-191 | INJECTION, SOLUTION | 24 mg | INTRAVENOUS | ANDA | 20 sections |
| Foscarnet Sodium | Human Prescription Drug Label | 1 | 68083-389 | INJECTION, SOLUTION | 24 mg | INTRAVENOUS | ANDA | 21 sections |
| Foscarnet Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70121-1744 | INJECTION | 24 mg | INTRAVENOUS | ANDA | 20 sections |
| Foscavir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 76310-024 | INJECTION, SOLUTION | 24 mg | INTRAVENOUS | NDA | 24 sections |
| Foscavir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 76310-024 | INJECTION, SOLUTION | 24 mg | INTRAVENOUS | NDA | 24 sections |