allopurinol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
124 315-30-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • zyloprim
  • allopurinol
  • tautomeric mixture of 1H-pyrazolo[3,4-d]pyrimidin-4-ol and 1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
  • allopurinol sodium
A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms.
  • Molecular weight: 136.11
  • Formula: C5H4N4O
  • CLOGP: 0.63
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 74.69
  • ALOGS: -0.79
  • ROTB: 0
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.40 g O
0.40 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.80 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 12 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 97.71 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 67 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.58 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 11 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.97 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.80 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class AAK1,ACVR2A,ACVR2B,ALK,AURKA,AURKB,AURKC,AXL,BRAF,CAMK2B,CAMK2D,CDK1,CDK9,CHEK1,CLK2,CLK4,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,ERBB2,FLT3,GRK1,GRK2,GRK3,GSK3B,IRAK1,IRAK3,ITK,JAK1,JAK2,MAP2K6,MAP3K1,MAP3K10,MAP3K21,MAP4K1,MAP4K3,MAP4K5,MAPK1,MAPK7,MAPK9,MARK4,MKNK2,NTRK1,PRKAA2,PRKCD,PRKDC,SGK1,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ULK2 57
kinase-selectivity-class AURKA,AURKB,BRAF,CAMK2D,CDK9,CLK2,CLK4,DYRK1B,EGFR,ERBB2,GRK2,GRK3,GSK3B,HASPIN,IRAK1,MAP2K3,MAP2K6,MAP3K10,MAP3K19,MAP3K21,MAPK1,MARK4,MKNK2,PDK1,PRKAA1,PRKAA2,ROCK1,SGK1,ULK1 29
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Aug. 19, 1966 FDA PROMETHEUS LABS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug reaction with eosinophilia and systemic symptoms 2745.06 9.82 1378 153815 41380 90431874
Acute kidney injury 1354.43 9.82 2158 153035 318229 90155025
Febrile neutropenia 779.40 9.82 1146 154047 157203 90316051
Anaemia 561.76 9.82 1596 153597 351206 90122048
Toxic epidermal necrolysis 561.06 9.82 457 154736 32071 90441183
Stevens-Johnson syndrome 522.06 9.82 420 154773 28956 90444298
Pemphigus 514.53 9.82 9 155184 326855 90146399
Hyperkalaemia 494.68 9.82 583 154610 64381 90408873
Renal failure 480.08 9.82 829 154364 130178 90343076
Cytokine release syndrome 465.65 9.82 385 154808 27588 90445666
Glossodynia 446.51 9.82 26 155167 321753 90151501
Systemic lupus erythematosus 427.72 9.82 57 155136 361839 90111415
Drug ineffective 384.80 9.82 1162 154031 1383136 89090118
Renal impairment 380.78 9.82 663 154530 104758 90368496
Hand deformity 374.32 9.82 37 155156 296325 90176929
Rash maculo-papular 356.68 9.82 394 154799 40539 90432715
Maternal exposure during pregnancy 346.65 9.82 94 155099 359969 90113285
Cardiac failure 343.77 9.82 648 154545 108848 90364406
Pericarditis 343.07 9.82 33 155160 270118 90203136
Arthropathy 326.54 9.82 110 155083 366132 90107122
Thrombocytopenia 316.85 9.82 929 154264 207796 90265458
Duodenal ulcer perforation 312.72 9.82 16 155177 221272 90251982
Melaena 308.47 9.82 338 154855 34459 90438795
Gout 303.67 9.82 243 154950 16616 90456638
Alopecia 303.57 9.82 242 154951 494829 89978425
Tumour lysis syndrome 303.15 9.82 206 154987 10946 90462308
Pancytopenia 302.53 9.82 649 154544 119614 90353640
Helicobacter infection 298.07 9.82 24 155169 226826 90246428
Synovitis 285.40 9.82 104 155089 329648 90143606
Sepsis 285.09 9.82 813 154380 179001 90294253
Blood creatinine increased 279.36 9.82 568 154625 100818 90372436
Irritable bowel syndrome 278.06 9.82 20 155173 207428 90265826
Discomfort 276.74 9.82 65 155128 274270 90198984
Wound 273.52 9.82 89 155104 302891 90170363
Rheumatoid factor positive 273.02 9.82 4 155189 171646 90301608
Folliculitis 270.21 9.82 21 155172 204332 90268922
Muscle injury 269.42 9.82 7 155186 176647 90296607
Psoriatic arthropathy 262.50 9.82 39 155154 228296 90244958
Atrial fibrillation 260.16 9.82 652 154541 132959 90340295
Abdominal discomfort 250.39 9.82 269 154924 477059 89996195
Therapeutic product effect decreased 247.97 9.82 83 155110 277488 90195766
Hypotension 236.53 9.82 1143 154050 324254 90149000
Joint swelling 234.84 9.82 311 154882 502989 89970265
Drug interaction 231.20 9.82 1012 154181 275441 90197813
Haemoglobin decreased 226.94 9.82 701 154492 161255 90311999
Dehydration 226.19 9.82 790 154403 193657 90279597
Neutropenia 223.23 9.82 868 154325 224036 90249218
Rheumatoid arthritis 218.68 9.82 180 155013 362434 90110820
Infusion related reaction 217.27 9.82 236 154957 416544 90056710
Eosinophilia 215.33 9.82 255 154938 28278 90444976
Plasma cell myeloma 214.37 9.82 305 154888 40523 90432731
Contraindicated product administered 213.57 9.82 143 155050 319996 90153258
Exposure during pregnancy 209.95 9.82 73 155120 238337 90234917
Lactic acidosis 208.25 9.82 337 154856 50126 90423128
Ill-defined disorder 207.00 9.82 34 155159 184857 90288397
Treatment failure 199.74 9.82 138 155055 303790 90169464
Hyponatraemia 199.27 9.82 591 154602 132947 90340307
Pain 195.32 9.82 961 154232 995380 89477874
Chronic kidney disease 190.75 9.82 323 154870 49868 90423386
Impaired healing 186.06 9.82 84 155109 234115 90239139
Toxic skin eruption 184.71 9.82 178 155015 15596 90457658
Hepatic enzyme increased 183.86 9.82 208 154985 360528 90112726
Injury 179.75 9.82 57 155136 197292 90275962
Sleep disorder due to general medical condition, insomnia type 179.59 9.82 10 155183 128684 90344570
Bradycardia 175.71 9.82 421 154772 83426 90389828
Swelling 172.82 9.82 282 154911 418776 90054478
Platelet count decreased 171.95 9.82 571 154622 136398 90336856
Hypoglycaemia 168.78 9.82 371 154822 69477 90403777
Syncope 166.49 9.82 553 154640 132110 90341144
Blood urea increased 163.80 9.82 230 154963 30183 90443071
Product prescribing error 156.49 9.82 224 154969 29921 90443333
Fibromyalgia 156.15 9.82 79 155114 206190 90267064
Hypersensitivity 155.85 9.82 342 154851 454335 90018919
Sinusitis 153.83 9.82 218 154975 342870 90130384
International normalised ratio increased 153.36 9.82 284 154909 47032 90426222
Nasopharyngitis 153.31 9.82 290 154903 406814 90066440
Drug hypersensitivity 142.00 9.82 370 154823 463239 90010015
Multiple organ dysfunction syndrome 139.83 9.82 340 154853 67996 90405258
Haematoma 138.82 9.82 244 154949 38804 90434450
Gastrointestinal disorder 137.39 9.82 142 155051 256545 90216709
Drug intolerance 137.24 9.82 357 154836 447234 90026020
Labelled drug-drug interaction medication error 136.84 9.82 146 155047 14436 90458818
Type 2 diabetes mellitus 136.53 9.82 90 155103 203154 90270100
Intentional product use issue 135.26 9.82 104 155089 216788 90256466
Lip dry 134.46 9.82 10 155183 100945 90372309
Diabetes mellitus inadequate control 134.44 9.82 163 155030 18521 90454733
Gastrointestinal haemorrhage 132.29 9.82 397 154796 89851 90383403
Breast cancer stage III 130.05 9.82 3 155190 84444 90388810
Grip strength decreased 129.76 9.82 7 155186 92569 90380685
Multiple drug therapy 126.16 9.82 101 155092 6908 90466346
Sleep disorder 124.70 9.82 94 155099 197936 90275318
Blister 123.47 9.82 153 155040 254845 90218409
Hyperuricaemia 123.46 9.82 98 155095 6621 90466633
Oedema peripheral 120.33 9.82 805 154388 257110 90216144
Pyrexia 119.94 9.82 1688 153505 658797 89814457
Facet joint syndrome 119.73 9.82 14 155179 98375 90374879
Hypokalaemia 116.38 9.82 489 154704 130627 90342627
Blood uric acid increased 115.77 9.82 100 155093 7604 90465650
C-reactive protein abnormal 113.90 9.82 38 155155 127391 90345863
Neutropenic sepsis 112.67 9.82 147 155046 17983 90455271
Diarrhoea 109.38 9.82 2233 152960 936957 89536297
Musculoskeletal stiffness 108.29 9.82 215 154978 296317 90176937
Arthralgia 108.29 9.82 835 154358 777687 89695567
Product use issue 108.22 9.82 254 154939 329665 90143589
Blood cholesterol increased 106.92 9.82 119 155074 207893 90265361
Chronic lymphocytic leukaemia 106.82 9.82 67 155126 3103 90470151
Osteoarthritis 105.03 9.82 108 155085 195622 90277632
Pulmonary fibrosis 103.44 9.82 28 155165 107475 90365779
Joint range of motion decreased 102.55 9.82 52 155141 135591 90337663
Live birth 102.11 9.82 9 155184 79098 90394156
Hypercholesterolaemia 101.47 9.82 24 155169 100868 90372386
Lower respiratory tract infection 100.15 9.82 172 155021 250487 90222767
Wound infection 99.98 9.82 29 155164 106373 90366881
Acute myeloid leukaemia 99.33 9.82 148 155045 20492 90452762
Completed suicide 99.08 9.82 63 155130 144995 90328259
Autoimmune disorder 98.34 9.82 9 155184 76735 90396519
Sopor 95.48 9.82 160 155033 24484 90448770
Liver injury 93.93 9.82 92 155101 170475 90302779
Peripheral venous disease 92.64 9.82 16 155177 83905 90389349
Hip arthroplasty 92.34 9.82 11 155182 76197 90397057
Weight increased 90.48 9.82 388 154805 417539 90055715
Metabolic acidosis 89.33 9.82 253 154940 55423 90417831
Gait inability 89.04 9.82 72 155121 146384 90326870
Pleural effusion 87.45 9.82 402 154791 111589 90361665
Therapeutic product effect incomplete 86.04 9.82 124 155069 193772 90279482
Face oedema 84.55 9.82 147 155046 23171 90450083
Prescribed overdose 84.00 9.82 31 155162 97594 90375660
Adjustment disorder with depressed mood 83.78 9.82 3 155190 56750 90416504
Epistaxis 83.07 9.82 327 154866 84798 90388456
Anuria 82.68 9.82 114 155079 14704 90458550
Headache 82.44 9.82 1014 154179 861732 89611522
Death 81.57 9.82 1164 154029 455387 90017867
Product monitoring error 80.77 9.82 65 155128 4479 90468775
Road traffic accident 80.25 9.82 42 155151 107584 90365670
Adverse event 80.18 9.82 51 155142 117367 90355887
Blood lactate dehydrogenase increased 78.25 9.82 151 155042 25781 90447473
Night sweats 77.41 9.82 64 155129 128702 90344552
Dermatitis exfoliative generalised 76.84 9.82 69 155124 5524 90467730
Respiratory failure 76.01 9.82 402 154791 118016 90355238
Urticaria 74.82 9.82 279 154914 312455 90160799
Injection site reaction 74.70 9.82 32 155161 92048 90381206
Wheezing 74.32 9.82 188 155005 237892 90235362
Bursitis 73.65 9.82 70 155123 131584 90341670
Pregnancy 72.65 9.82 10 155183 62037 90411217
Knee arthroplasty 72.26 9.82 26 155167 83156 90390098
Hyperphosphataemia 72.23 9.82 56 155137 3655 90469599
Asthenia 71.75 9.82 1298 153895 532453 89940801
Blood potassium increased 71.61 9.82 128 155065 20621 90452633
Hypoaesthesia 71.52 9.82 286 154907 313924 90159330
Bone erosion 71.32 9.82 5 155188 53016 90420238
Pneumonia 69.77 9.82 1504 153689 636555 89836699
Dermatitis exfoliative 69.63 9.82 65 155128 5471 90467783
Mucosal inflammation 69.40 9.82 237 154956 57388 90415866
Product quality issue 68.56 9.82 25 155168 79300 90393954
Dilatation intrahepatic duct acquired 68.28 9.82 31 155162 737 90472517
Intentional overdose 66.51 9.82 39 155154 93795 90379459
Septic shock 66.36 9.82 303 154890 83857 90389397
Asthma 65.40 9.82 205 154988 241955 90231299
Stomatitis 65.09 9.82 246 154947 274452 90198802
Lupus vulgaris 64.44 9.82 3 155190 45056 90428198
Sciatica 63.95 9.82 48 155145 101334 90371920
White blood cell count decreased 63.67 9.82 497 154696 166612 90306642
Tubulointerstitial nephritis 62.77 9.82 136 155057 25207 90448047
Dementia 62.51 9.82 131 155062 23730 90449524
X-ray abnormal 61.93 9.82 4 155189 45420 90427834
Dyspnoea 61.28 9.82 1956 153237 878999 89594255
Splenomegaly 61.23 9.82 92 155101 12832 90460422
Injection site erythema 60.40 9.82 48 155145 98454 90374800
Conjunctivitis 60.18 9.82 138 155055 26568 90446686
Purpura 60.01 9.82 98 155095 14680 90458574
Depression 59.67 9.82 288 154905 300313 90172941
Nail disorder 59.49 9.82 14 155179 59053 90414201
Lower limb fracture 59.32 9.82 36 155157 84977 90388277
Cardiac failure congestive 58.58 9.82 328 154865 98366 90374888
Dialysis 58.52 9.82 84 155109 11245 90462009
Off label use 57.93 9.82 1442 153751 1100810 89372444
Prescribed underdose 57.84 9.82 28 155165 74991 90398263
Loss of personal independence in daily activities 57.50 9.82 90 155103 136015 90337239
Onychomadesis 57.34 9.82 6 155187 45992 90427262
Electrolyte imbalance 56.06 9.82 125 155068 23620 90449634
Leukopenia 56.04 9.82 329 154864 100381 90372873
Tumour flare 55.99 9.82 25 155168 571 90472683
Rhabdomyolysis 55.87 9.82 204 154989 51052 90422202
Obesity 55.69 9.82 59 155134 105448 90367806
Dermatitis bullous 55.52 9.82 78 155115 10238 90463016
Haematuria 55.30 9.82 158 155035 34779 90438475
Insomnia 54.92 9.82 340 154853 333134 90140120
Migraine 54.40 9.82 157 155036 190235 90283019
Cardioactive drug level increased 53.11 9.82 39 155154 2345 90470909
Alanine aminotransferase increased 53.10 9.82 366 154827 117972 90355282
Blood pressure inadequately controlled 52.63 9.82 59 155134 6165 90467089
Anaemia macrocytic 52.41 9.82 51 155142 4521 90468733
Red blood cell sedimentation rate increased 52.23 9.82 39 155154 82556 90390698
Petechiae 51.64 9.82 95 155098 15646 90457608
Hyperglycaemia 51.51 9.82 198 154995 50772 90422482
Charles Bonnet syndrome 51.39 9.82 13 155180 41 90473213
Agranulocytosis 51.29 9.82 154 155039 34848 90438406
Foot deformity 51.21 9.82 19 155174 59632 90413622
Back injury 51.21 9.82 9 155184 46613 90426641
Body mass index abnormal 50.85 9.82 25 155168 714 90472540
Acute generalised exanthematous pustulosis 50.48 9.82 87 155106 13616 90459638
Rash morbilliform 50.09 9.82 47 155146 3982 90469272
Hypervolaemia 49.78 9.82 146 155047 32611 90440643
Multiple sclerosis relapse 49.60 9.82 14 155179 52291 90420963
Shock haemorrhagic 49.45 9.82 81 155112 12164 90461090
Erythema multiforme 49.44 9.82 81 155112 12165 90461089
Acute febrile neutrophilic dermatosis 49.23 9.82 44 155149 3501 90469753
Epilepsy 49.23 9.82 41 155152 82165 90391089
Glomerular filtration rate decreased 49.15 9.82 97 155096 16835 90456419
Subdural haematoma 49.09 9.82 96 155097 16549 90456705
Paraesthesia 48.99 9.82 241 154952 250085 90223169
Exostosis 48.97 9.82 15 155178 53119 90420135
Blood cholesterol decreased 48.54 9.82 34 155159 1897 90471357
Breast cancer stage II 48.51 9.82 3 155190 35331 90437923
General physical health deterioration 48.49 9.82 866 154327 354249 90119005
Anxiety 48.36 9.82 321 154872 309451 90163803
Pemphigoid 48.21 9.82 68 155125 8958 90464296
Ear infection 48.05 9.82 30 155163 69745 90403509
Condition aggravated 47.72 9.82 725 154468 594820 89878434
Constipation 47.66 9.82 709 154484 279686 90193568
Drug eruption 47.44 9.82 151 155042 35256 90437998
Sternal fracture 46.50 9.82 39 155154 2848 90470406
Bone marrow failure 46.49 9.82 141 155052 32080 90441174
Neovascularisation 46.43 9.82 31 155162 1599 90471655
Dyspnoea exertional 45.41 9.82 244 154949 72044 90401210
Lymphocytosis 45.23 9.82 39 155154 2958 90470296
Abortion spontaneous 45.11 9.82 18 155175 54038 90419216
Renal disorder 44.96 9.82 155 155038 37704 90435550
Injection site pain 44.83 9.82 150 155043 173549 90299705
Libido increased 44.53 9.82 31 155162 1713 90471541
Peripheral circulatory failure 44.47 9.82 30 155163 1574 90471680
Shock 44.44 9.82 129 155064 28649 90444605
Immune effector cell-associated neurotoxicity syndrome 44.26 9.82 52 155141 5716 90467538
Hypercalcaemia 44.04 9.82 144 155049 34096 90439158
Sinoatrial block 43.62 9.82 25 155168 980 90472274
Enanthema 43.50 9.82 20 155173 490 90472764
Memory impairment 43.30 9.82 182 155011 197062 90276192
Fatigue 42.95 9.82 1581 153612 1152442 89320812
Disseminated intravascular coagulation 42.80 9.82 106 155087 21432 90451822
Serositis 42.29 9.82 27 155166 1290 90471964
Mobility decreased 42.12 9.82 254 154939 250480 90222774
Blood creatine phosphokinase increased 41.90 9.82 141 155052 33882 90439372
Cardiac failure chronic 41.83 9.82 50 155143 5596 90467658
Soft tissue injury 41.66 9.82 32 155161 2060 90471194
Injection site pruritus 41.64 9.82 20 155173 53814 90419440
Arrhythmia 41.60 9.82 163 155030 42169 90431085
Blast crisis in myelogenous leukaemia 41.47 9.82 21 155172 640 90472614
Gamma-glutamyltransferase increased 41.32 9.82 151 155042 37801 90435453
Neuroglycopenia 41.21 9.82 25 155168 1090 90472164
Lupus-like syndrome 41.20 9.82 16 155177 48830 90424424
Atrioventricular block first degree 40.91 9.82 61 155132 8450 90464804
Right ventricular failure 40.82 9.82 97 155096 19108 90454146
Azotaemia 40.68 9.82 48 155145 5300 90467954
Muscle spasticity 40.63 9.82 6 155187 35316 90437938
Laryngitis 40.58 9.82 18 155175 50735 90422519
Suicidal ideation 40.45 9.82 40 155153 73815 90399439
Fall 39.96 9.82 1094 154099 480716 89992538
Allergy to chemicals 39.56 9.82 40 155153 3714 90469540
Injection site swelling 39.48 9.82 27 155166 59812 90413442
Blood alkaline phosphatase increased 39.32 9.82 175 155018 47904 90425350
Hepatocellular injury 39.26 9.82 124 155069 28834 90444420
Klebsiella infection 38.75 9.82 66 155127 10231 90463023
Angioedema 38.75 9.82 216 154977 64660 90408594
Pulmonary oedema 38.63 9.82 209 154984 61871 90411383
Mucosal erosion 38.45 9.82 29 155164 1816 90471438
Hyperbilirubinaemia 38.25 9.82 78 155115 13858 90459396
Haemodialysis 38.25 9.82 60 155133 8687 90464567
Cerebral haemorrhage 38.13 9.82 138 155055 34384 90438870
Synovial disorder 38.05 9.82 36 155157 3082 90470172
Infection 37.76 9.82 417 154776 361677 90111577
Exercise tolerance decreased 37.56 9.82 55 155138 7496 90465758
Aspartate aminotransferase increased 37.46 9.82 303 154890 102634 90370620
Onychomycosis 37.36 9.82 9 155184 37367 90435887
Hostility 37.22 9.82 31 155162 2242 90471012
Encephalopathy 37.19 9.82 168 155025 46276 90426978
Differentiation syndrome 37.16 9.82 25 155168 1306 90471948
Frequent bowel movements 37.15 9.82 26 155167 56909 90416345
Central nervous system lupus 36.62 9.82 25 155168 1338 90471916
Gravitational oedema 36.52 9.82 24 155169 1205 90472049
Post-traumatic neck syndrome 36.50 9.82 32 155161 2482 90470772
Hepatic cirrhosis 36.11 9.82 33 155160 63220 90410034
Acute motor-sensory axonal neuropathy 36.09 9.82 16 155177 359 90472895
Presyncope 35.86 9.82 128 155065 31677 90441577
Psoriasis 35.83 9.82 131 155062 147623 90325631
Anti-neutrophil cytoplasmic antibody positive vasculitis 35.75 9.82 39 155154 3954 90469300
Pulmonary arterial hypertension 35.38 9.82 112 155081 26075 90447179
Leukocytosis 35.18 9.82 125 155068 30865 90442389
Pericardial effusion 34.72 9.82 140 155053 36693 90436561
Hypoxia 34.31 9.82 227 154966 72172 90401082
Therapeutic drug monitoring analysis incorrectly performed 34.28 9.82 15 155178 326 90472928
Cholestasis 34.24 9.82 138 155055 36161 90437093
Lip erosion 33.96 9.82 23 155170 1215 90472039
End stage renal disease 33.67 9.82 56 155137 8515 90464739
Blood creatine increased 33.58 9.82 50 155143 6917 90466337
Adverse drug reaction 33.49 9.82 96 155097 116605 90356649
Blood phosphorus increased 33.25 9.82 39 155154 4279 90468975
Thrombosis 33.12 9.82 227 154966 73024 90400230
Hypovolaemic shock 32.90 9.82 50 155143 7044 90466210
Skin exfoliation 32.83 9.82 214 154979 67699 90405555
Acute respiratory failure 32.70 9.82 153 155040 42765 90430489
Ecchymosis 32.68 9.82 68 155125 12255 90460999
Sleep disorder due to a general medical condition 32.55 9.82 18 155175 44720 90428534
Neutrophil count decreased 32.53 9.82 222 154971 71310 90401944
Gastric polyps 32.38 9.82 40 155153 4632 90468622
Lichenoid keratosis 32.35 9.82 30 155163 2504 90470750
HLA-B*5801 assay positive 32.23 9.82 6 155187 0 90473254
Disorientation 31.97 9.82 155 155038 43959 90429295
Dysuria 31.90 9.82 143 155050 39258 90433996
Ear pain 31.89 9.82 31 155162 57671 90415583
Thermohypoaesthesia 31.88 9.82 11 155182 122 90473132
Taste disorder 31.83 9.82 35 155158 61511 90411743
Hyperpyrexia 31.78 9.82 40 155153 4721 90468533
Dry mouth 31.67 9.82 185 155008 183874 90289380
Colitis ulcerative 31.47 9.82 34 155159 60232 90413022
Medication error 31.25 9.82 250 154943 84402 90388852
Lung disorder 31.25 9.82 141 155052 149742 90323512
Haematocrit decreased 31.05 9.82 148 155045 41684 90431570
Pulmonary congestion 30.86 9.82 88 155105 19345 90453909
Suicide attempt 30.76 9.82 51 155142 75348 90397906
Inappropriate antidiuretic hormone secretion 30.66 9.82 88 155105 19417 90453837
Pulmonary hypertension 30.52 9.82 149 155044 42374 90430880
Platelet disorder 30.25 9.82 28 155165 2331 90470923
Sight disability 30.16 9.82 11 155182 145 90473109
Hypocalcaemia 30.08 9.82 148 155045 42220 90431034
Allergic reaction to excipient 29.98 9.82 18 155175 770 90472484
Underdose 29.88 9.82 29 155164 53988 90419266
Joint stiffness 29.83 9.82 55 155138 77987 90395267
Oliguria 29.80 9.82 60 155133 10564 90462690
Drug tolerance decreased 29.73 9.82 9 155184 32121 90441133
Dermatitis artefacta 29.62 9.82 9 155184 64 90473190
Chemical burn of oral cavity 29.62 9.82 9 155184 64 90473190
Rash erythematous 29.58 9.82 202 154991 64902 90408352
Cardiomegaly 29.38 9.82 85 155108 18840 90454414
Potentiating drug interaction 29.27 9.82 42 155151 5620 90467634
Staphylococcal sepsis 28.75 9.82 55 155138 9328 90463926
Orthopnoea 28.67 9.82 46 155147 6789 90466465
Tachypnoea 28.66 9.82 91 155102 21218 90452036
Swelling face 28.27 9.82 237 154956 81115 90392139
Urine output decreased 28.25 9.82 65 155128 12538 90460716
Joint dislocation 28.25 9.82 21 155172 44561 90428693
Adverse reaction 28.09 9.82 8 155185 29704 90443550
Macular degeneration 28.03 9.82 15 155178 37955 90435299
Activated partial thromboplastin time prolonged 27.94 9.82 49 155144 7776 90465478
Hepatic failure 27.65 9.82 138 155055 39590 90433664
Hepatotoxicity 27.62 9.82 153 155040 45689 90427565
Liver function test abnormal 27.57 9.82 165 155028 50680 90422574
Mixed liver injury 27.56 9.82 48 155145 7575 90465679
Intentional self-injury 27.54 9.82 8 155185 29326 90443928
Cardiac failure acute 27.27 9.82 62 155131 11867 90461387
Inflammation 26.88 9.82 187 155006 178405 90294849
Injection site bruising 26.77 9.82 30 155163 52277 90420977
Rash pruritic 26.73 9.82 236 154957 81978 90391276
Transfusion 26.62 9.82 78 155115 17410 90455844
Human herpesvirus 6 infection 26.43 9.82 31 155162 3401 90469853
Clostridium difficile colitis 26.37 9.82 103 155090 26603 90446651
Upper gastrointestinal haemorrhage 26.36 9.82 93 155100 22883 90450371
Foetal exposure during pregnancy 26.27 9.82 21 155172 42954 90430300
Walking aid user 26.25 9.82 14 155179 35492 90437762
Bradykinesia 26.20 9.82 44 155149 6744 90466510
Inappropriate schedule of product administration 26.17 9.82 150 155043 149783 90323471
Red blood cell count decreased 26.15 9.82 152 155041 46199 90427055
Serum ferritin increased 26.07 9.82 46 155147 7335 90465919
Oral mucosa erosion 25.83 9.82 21 155172 1468 90471786
Hypertensive heart disease 25.78 9.82 27 155166 2613 90470641
Therapeutic drug monitoring analysis not performed 25.75 9.82 20 155173 1309 90471945
Abdominal pain upper 25.57 9.82 408 154785 332266 90140988
Blood bilirubin increased 25.47 9.82 144 155049 43326 90429928
Device dislocation 25.43 9.82 11 155182 31471 90441783
Multimorbidity 25.30 9.82 15 155178 627 90472627
Urosepsis 25.27 9.82 87 155106 21145 90452109
Cerebellar stroke 25.23 9.82 13 155180 411 90472843
Erythema 25.15 9.82 541 154652 228705 90244549
Prerenal failure 25.01 9.82 24 155169 2091 90471163
Aplastic anaemia 25.00 9.82 64 155129 13205 90460049
Hallucination 25.00 9.82 196 154997 65763 90407491
Full blood count decreased 24.98 9.82 109 155084 29580 90443674
Peripheral arterial occlusive disease 24.96 9.82 35 155158 4586 90468668
Hypertensive crisis 24.89 9.82 77 155116 17707 90455547
Urinary tract infection 24.74 9.82 692 154501 304940 90168314
Vessel puncture site haemorrhage 24.72 9.82 9 155184 118 90473136
Hypoglycaemic coma 24.70 9.82 28 155165 2962 90470292
Atrial flutter 24.69 9.82 56 155137 10702 90462552
Analgesic therapy 24.67 9.82 15 155178 657 90472597
Parkinsonism 24.62 9.82 66 155127 13999 90459255
Wrist deformity 24.53 9.82 29 155164 3209 90470045
Mantle cell lymphoma 24.52 9.82 15 155178 664 90472590
Tonsillar haemorrhage 24.52 9.82 11 155182 254 90473000
Blood sodium decreased 24.48 9.82 103 155090 27510 90445744
SJS-TEN overlap 24.40 9.82 18 155175 1090 90472164
Anticoagulant therapy 24.39 9.82 16 155177 801 90472453
Aortic stenosis 24.36 9.82 41 155152 6295 90466959
Paraesthesia oral 24.12 9.82 12 155181 31647 90441607
Product dose omission issue 24.03 9.82 353 154840 291334 90181920
Injection site rash 23.81 9.82 6 155187 24167 90449087
Craniofacial fracture 23.79 9.82 13 155180 464 90472790
Hepatic function abnormal 23.70 9.82 148 155045 46140 90427114
Nephrogenic anaemia 23.68 9.82 25 155168 2441 90470813
Musculoskeletal pain 23.53 9.82 184 155009 171067 90302187
Encephalitis 23.41 9.82 56 155137 11078 90462176
Uraemic encephalopathy 23.25 9.82 11 155182 288 90472966
Eosinopenia 23.24 9.82 8 155185 88 90473166
Vaginal discharge 23.11 9.82 3 155190 19461 90453793
Fixed eruption 23.09 9.82 21 155172 1709 90471545
Antacid therapy 23.08 9.82 15 155178 739 90472515
Appendicolith 22.95 9.82 15 155178 746 90472508
Mononeuropathy multiplex 22.93 9.82 12 155181 392 90472862
Myelofibrosis 22.86 9.82 20 155173 1547 90471707
Hyperthermia 22.84 9.82 53 155140 10282 90462972
Hospice care 22.81 9.82 51 155142 9653 90463601
Mood swings 22.73 9.82 4 155189 20698 90452556
Drug abuse 22.71 9.82 69 155124 82278 90390976
Autonomic neuropathy 22.41 9.82 19 155174 1408 90471846
Tachyarrhythmia 22.15 9.82 36 155157 5370 90467884
Therapy non-responder 22.15 9.82 140 155053 136564 90336690
Cardiorenal syndrome 22.12 9.82 17 155176 1095 90472159
Drug therapy 22.12 9.82 15 155178 794 90472460
Strangulated umbilical hernia 22.09 9.82 5 155188 8 90473246
Chronic myeloid leukaemia 22.09 9.82 25 155168 2639 90470615
Procedural pain 22.07 9.82 15 155178 33345 90439909
Food allergy 22.06 9.82 8 155185 25470 90447784
Haematemesis 21.97 9.82 115 155078 33611 90439643
Bradyarrhythmia 21.97 9.82 24 155169 2437 90470817
Lip oedema 21.94 9.82 33 155160 4606 90468648
Immunodeficiency 21.90 9.82 25 155168 43209 90430045
Coagulation test abnormal 21.89 9.82 16 155177 955 90472299
Aplasia pure red cell 21.84 9.82 35 155158 5159 90468095
Stupor 21.78 9.82 36 155157 5446 90467808
Haematochezia 21.75 9.82 201 154992 70712 90402542
Hypersensitivity vasculitis 21.72 9.82 31 155162 4128 90469126
Mucosal ulceration 21.58 9.82 17 155176 1136 90472118
Disturbance in social behaviour 21.55 9.82 31 155162 4157 90469097
Tenosynovitis stenosans 21.44 9.82 30 155163 3923 90469331
COVID-19 pneumonia 21.22 9.82 74 155119 18103 90455151
Mandibular mass 21.16 9.82 9 155184 182 90473072
Antinuclear antibody positive 21.09 9.82 48 155145 9193 90464061
Synovial fluid analysis 20.95 9.82 25 155168 2793 90470461
Accidental exposure to product 20.92 9.82 25 155168 42341 90430913
Cholestatic liver injury 20.86 9.82 29 155164 3768 90469486
Injection site urticaria 20.85 9.82 3 155190 18008 90455246
Proteinuria 20.75 9.82 87 155106 23204 90450050
Drug tolerance 20.71 9.82 3 155190 17913 90455341
Hypercreatininaemia 20.68 9.82 14 155179 739 90472515
Fracture blisters 20.67 9.82 7 155186 73 90473181
Necrotising ulcerative gingivostomatitis 20.62 9.82 6 155187 36 90473218
Alopecia scarring 20.59 9.82 9 155184 195 90473059
Mental status changes 20.51 9.82 139 155054 44540 90428714
Blood glucose increased 20.33 9.82 251 154942 94995 90378259
Administration site discomfort 20.25 9.82 8 155185 133 90473121
Escherichia sepsis 20.22 9.82 36 155157 5780 90467474
No adverse event 20.19 9.82 55 155138 67927 90405327
Subarachnoid haemorrhage 20.13 9.82 72 155121 17832 90455422
Delirium 20.09 9.82 101 155092 104258 90368996
Peripheral swelling 20.08 9.82 546 154647 412560 90060694
Acute myeloid leukaemia recurrent 20.02 9.82 21 155172 2036 90471218
Respiratory tract congestion 19.98 9.82 11 155182 27399 90445855
Myeloblast percentage decreased 19.95 9.82 6 155187 41 90473213
Haemoptysis 19.93 9.82 111 155082 33209 90440045
Localised oedema 19.84 9.82 37 155156 6157 90467097
Gait disturbance 19.50 9.82 321 154872 260175 90213079
Cytopenia 19.48 9.82 70 155123 17379 90455875
Escherichia bacteraemia 19.30 9.82 35 155158 5700 90467554
Crepitations 19.13 9.82 45 155148 8807 90464447
Transaminases increased 19.09 9.82 119 155074 37073 90436181
Seronegative arthritis 19.01 9.82 4 155189 18230 90455024
Peripheral sensory neuropathy 18.88 9.82 46 155147 9204 90464050
Abdominal wall wound 18.88 9.82 7 155186 97 90473157
Calciphylaxis 18.87 9.82 26 155167 3350 90469904
Haemorrhage intracranial 18.81 9.82 63 155130 15099 90458155
Liver function test increased 18.79 9.82 78 155115 84777 90388477
Cardiopulmonary failure 18.69 9.82 29 155164 4159 90469095
Gouty arthritis 18.60 9.82 12 155181 584 90472670
Lung infiltration 18.52 9.82 63 155130 15219 90458035
Renal infarct 18.48 9.82 18 155175 1597 90471657
Lymphadenopathy 18.45 9.82 138 155055 45637 90427617
Mitral valve incompetence 18.42 9.82 82 155111 22442 90450812
Leukocyturia 18.42 9.82 18 155175 1604 90471650
Loss of consciousness 18.40 9.82 340 154853 139898 90333356
Platelet dysfunction 18.37 9.82 7 155186 105 90473149
Vascular malformation 18.35 9.82 13 155180 739 90472515
Lung consolidation 18.18 9.82 31 155162 4809 90468445
Atrioventricular block complete 18.15 9.82 47 155146 9764 90463490
Respiratory disorder 18.10 9.82 54 155139 64762 90408492
Stenosis 18.04 9.82 20 155173 2064 90471190
Blood pressure decreased 18.03 9.82 202 154991 74693 90398561
Micturition disorder 18.01 9.82 24 155169 2996 90470258
Duodenal stenosis 17.99 9.82 12 155181 618 90472636
Escherichia infection 17.94 9.82 64 155129 15831 90457423
Breast cancer 17.91 9.82 41 155152 53720 90419534
Scleritis 17.80 9.82 32 155161 5176 90468078
Papillary muscle rupture 17.78 9.82 5 155188 26 90473228
Nodal arrhythmia 17.75 9.82 16 155177 1287 90471967
Acidosis 17.69 9.82 55 155138 12681 90460573
International normalised ratio abnormal 17.69 9.82 27 155166 3818 90469436
Haemolytic anaemia 17.64 9.82 52 155141 11645 90461609
Initial insomnia 17.64 9.82 45 155148 9265 90463989
Diabetic hyperosmolar coma 17.59 9.82 10 155183 386 90472868
Diverticulum oesophageal 17.55 9.82 8 155185 192 90473062
Gastrooesophageal reflux disease 17.53 9.82 191 155002 166146 90307108
Leukostasis syndrome 17.52 9.82 6 155187 65 90473189
Product use in unapproved indication 17.50 9.82 440 154753 335796 90137458
Paranasal cyst 17.48 9.82 13 155180 797 90472457
Retroperitoneal haematoma 17.44 9.82 25 155168 3343 90469911
Ileus 17.31 9.82 65 155128 16481 90456773
Cytomegalovirus infection reactivation 17.23 9.82 40 155153 7760 90465494
Chronic myeloid leukaemia recurrent 17.23 9.82 9 155184 293 90472961
Pleuritic pain 17.23 9.82 48 155145 10413 90462841
Amaurosis 17.20 9.82 13 155180 817 90472437
Autoimmune haemolytic anaemia 17.19 9.82 33 155160 5612 90467642
Subdural haemorrhage 17.12 9.82 25 155168 3398 90469856
B-cell unclassifiable lymphoma high grade 17.11 9.82 4 155189 8 90473246
Urinary retention 17.08 9.82 117 155076 37627 90435627
Pseudomonal bacteraemia 17.03 9.82 19 155174 1975 90471279
Rash macular 16.89 9.82 99 155094 30181 90443073
Affect lability 16.82 9.82 5 155188 18058 90455196
Acute pulmonary oedema 16.82 9.82 45 155148 9535 90463719
Neck pain 16.82 9.82 120 155073 113843 90359411
Cranial nerve disorder 16.74 9.82 12 155181 695 90472559
Chronic sinusitis 16.71 9.82 10 155183 23792 90449462
Erosive oesophagitis 16.59 9.82 18 155175 1813 90471441
Small fibre neuropathy 16.48 9.82 12 155181 712 90472542
Cardiovascular insufficiency 16.46 9.82 17 155176 1618 90471636
Maternal condition affecting foetus 16.45 9.82 8 155185 223 90473031
Gastritis erosive 16.44 9.82 36 155157 6719 90466535
Skin ulcer 16.41 9.82 144 155049 49931 90423323
Wrong technique in product usage process 16.35 9.82 65 155128 71506 90401748
Periorbital oedema 16.28 9.82 36 155157 6763 90466491
Uveitic glaucoma 16.22 9.82 4 155189 11 90473243
Neutropenic colitis 16.18 9.82 27 155166 4116 90469138
Mastoiditis 16.16 9.82 17 155176 1653 90471601
Necrotic angiodermatitis 16.12 9.82 3 155190 0 90473254
Klebsiella bacteraemia 16.08 9.82 21 155172 2571 90470683
Staphylococcal scalded skin syndrome 16.04 9.82 7 155186 151 90473103
Bacteraemia 15.90 9.82 78 155115 22222 90451032
Product used for unknown indication 15.86 9.82 12 155181 755 90472499
Muscle spasms 15.83 9.82 320 154873 251563 90221691
Generalised bullous fixed drug eruption 15.68 9.82 9 155184 354 90472900
Eye oedema 15.65 9.82 18 155175 1934 90471320
Lupus nephritis 15.65 9.82 29 155164 4803 90468451
Temperature regulation disorder 15.61 9.82 3 155190 14576 90458678
Hypertransaminasaemia 15.60 9.82 61 155132 15764 90457490
Performance enhancing product use 15.49 9.82 4 155189 14 90473240
Gastric ulcer 15.47 9.82 90 155103 27358 90445896
Ischaemic stroke 15.43 9.82 77 155116 22089 90451165
Diverticulum intestinal haemorrhagic 15.42 9.82 17 155176 1744 90471510
Stasis dermatitis 15.41 9.82 13 155180 957 90472297
Dermatitis 15.33 9.82 77 155116 22143 90451111
Glomerulonephritis 15.30 9.82 20 155173 2450 90470804
Limb discomfort 15.29 9.82 26 155167 38034 90435220
Dental restoration failure 15.28 9.82 14 155179 1150 90472104
Prothrombin time prolonged 15.27 9.82 44 155149 9728 90463526
Transient acantholytic dermatosis 15.23 9.82 6 155187 99 90473155
Deficiency anaemia 15.14 9.82 5 155188 48 90473206
Blood pressure fluctuation 15.12 9.82 43 155150 52370 90420884
Paraneoplastic syndrome 15.10 9.82 11 155182 653 90472601
Coronary artery disease 15.08 9.82 104 155089 33519 90439735
Haemoglobin increased 15.06 9.82 37 155156 7444 90465810
Sudden death 15.05 9.82 47 155146 10862 90462392
Mouth haemorrhage 14.99 9.82 40 155153 8461 90464793
Swollen tongue 14.98 9.82 132 155061 45824 90427430
Disease progression 14.80 9.82 362 154831 156253 90317001
Haemophagocytic lymphohistiocytosis 14.76 9.82 59 155134 15400 90457854
Injection site haemorrhage 14.75 9.82 16 155177 28302 90444952
Urticaria papular 14.70 9.82 6 155187 109 90473145
Chills 14.63 9.82 312 154881 131669 90341585
Dyspepsia 14.56 9.82 245 154948 197915 90275339
Skin erosion 14.51 9.82 23 155170 3359 90469895
Mucocutaneous haemorrhage 14.45 9.82 6 155187 114 90473140
Left ventricular failure 14.41 9.82 34 155159 6666 90466588
Neuroleptic malignant syndrome 14.39 9.82 4 155189 15092 90458162
Device difficult to use 14.35 9.82 6 155187 17519 90455735
Paradoxical drug reaction 14.34 9.82 31 155162 5735 90467519
Surgery 14.34 9.82 35 155158 44852 90428402
Anger 14.32 9.82 3 155190 13717 90459537
Schizophrenia 14.13 9.82 4 155189 14910 90458344
Radiculopathy 14.12 9.82 7 155186 18498 90454756
Joint effusion 14.10 9.82 69 155124 19641 90453613
Faeces discoloured 14.10 9.82 73 155120 21247 90452007
Atrophic glossitis 14.04 9.82 4 155189 22 90473232
Drug resistance 13.96 9.82 19 155174 30430 90442824
Halo vision 13.95 9.82 9 155184 438 90472816
Renal vasculitis 13.93 9.82 9 155184 439 90472815
Intentional product misuse 13.89 9.82 93 155100 89511 90383743
Neurotoxicity 13.85 9.82 73 155120 21394 90451860
Haemoperitoneum 13.79 9.82 23 155170 3505 90469749
Hypotonia 13.76 9.82 47 155146 11379 90461875
Middle insomnia 13.71 9.82 61 155132 16690 90456564
Prurigo 13.66 9.82 12 155181 933 90472321
Jaundice 13.66 9.82 99 155094 32418 90440836
HLA marker study positive 13.65 9.82 7 155186 219 90473035
Nasal mucosal erosion 13.64 9.82 5 155188 67 90473187
Diffuse large B-cell lymphoma 13.58 9.82 39 155154 8606 90464648
Lip haemorrhage 13.58 9.82 10 155183 604 90472650
Capillary leak syndrome 13.54 9.82 20 155173 2747 90470507
Chronic myeloid leukaemia transformation 13.52 9.82 6 155187 135 90473119
Hyperlipidaemia 13.48 9.82 76 155117 22840 90450414
Systemic infection 13.43 9.82 27 155166 4748 90468506
Blood loss anaemia 13.36 9.82 43 155150 10097 90463157
Pupillary reflex impaired 13.34 9.82 19 155174 2526 90470728
Ventricular tachycardia 13.28 9.82 80 155113 24628 90448626
Bundle branch block right 13.20 9.82 29 155164 5424 90467830
Cognitive disorder 13.17 9.82 179 155014 69228 90404026
Seizure 13.16 9.82 183 155010 152446 90320808
Multiple sclerosis 13.15 9.82 17 155176 27823 90445431
Generalised oedema 13.13 9.82 66 155127 18987 90454267
Acid base balance abnormal 13.12 9.82 8 155185 352 90472902
Tongue dry 12.99 9.82 13 155180 1192 90472062
Cerebral haematoma 12.97 9.82 25 155168 4264 90468990
Aortic valve sclerosis 12.95 9.82 13 155180 1197 90472057
Abdominal pain 12.94 9.82 814 154379 394907 90078347
Nephropathy 12.94 9.82 40 155153 9195 90464059
Allergic sinusitis 12.92 9.82 17 155176 2096 90471158
Hypochloraemia 12.90 9.82 19 155174 2603 90470651
Extensor plantar response 12.88 9.82 14 155179 1413 90471841
Spigelian hernia 12.86 9.82 4 155189 31 90473223
Blood electrolytes increased 12.86 9.82 4 155189 31 90473223
Fear of falling 12.84 9.82 10 155183 657 90472597
Hyperviscosity syndrome 12.81 9.82 7 155186 250 90473004
Hydrothorax 12.74 9.82 12 155181 1021 90472233
Blood uric acid decreased 12.67 9.82 11 155182 842 90472412
Duodenitis 12.67 9.82 25 155168 4338 90468916
Vasculitis necrotising 12.62 9.82 10 155183 674 90472580
Product administration error 12.61 9.82 83 155110 26340 90446914
Eosinophilic myocarditis 12.60 9.82 10 155183 675 90472579
Leukaemia 12.60 9.82 27 155166 4965 90468289
Feeling jittery 12.60 9.82 56 155137 15315 90457939
Red blood cell sedimentation rate decreased 12.60 9.82 12 155181 1036 90472218
Rib fracture 12.59 9.82 83 155110 26352 90446902
Cellulitis 12.52 9.82 223 154970 91114 90382140
Gouty tophus 12.51 9.82 7 155186 262 90472992
Proteus test positive 12.48 9.82 8 155185 385 90472869
Peripheral ischaemia 12.45 9.82 29 155164 5638 90467616
Pulmonary haemorrhage 12.45 9.82 36 155157 7977 90465277
Venoocclusive liver disease 12.45 9.82 30 155163 5963 90467291
Tremor 12.43 9.82 347 154846 152826 90320428
Ileal ulcer 12.42 9.82 12 155181 1054 90472200
Hypercapnic coma 12.41 9.82 7 155186 266 90472988
Brain natriuretic peptide increased 12.41 9.82 30 155163 5975 90467279
Fulminant type 1 diabetes mellitus 12.40 9.82 11 155182 867 90472387
Venoocclusive disease 12.38 9.82 18 155175 2437 90470817
Chronic lymphocytic leukaemia recurrent 12.37 9.82 8 155185 391 90472863
Circulatory collapse 12.36 9.82 79 155114 24825 90448429
Diverticulitis 12.34 9.82 125 155068 45062 90428192
Blood creatinine abnormal 12.29 9.82 24 155169 4133 90469121
Gastroenteritis 12.28 9.82 89 155104 29140 90444114
Serratia infection 12.24 9.82 12 155181 1073 90472181
Insulin-requiring type 2 diabetes mellitus 12.24 9.82 5 155188 91 90473163
Renal injury 12.22 9.82 42 155151 10201 90463053
Normochromic normocytic anaemia 12.20 9.82 27 155166 5075 90468179
Spinal fusion surgery 12.19 9.82 3 155190 12280 90460974
Atrioventricular block 12.18 9.82 38 155155 8777 90464477
Hypophosphataemia 12.09 9.82 54 155139 14800 90458454
Myelodysplastic syndrome 12.08 9.82 69 155124 20834 90452420
Hepatic necrosis 12.08 9.82 31 155162 6407 90466847
Blood potassium decreased 12.07 9.82 130 155063 47597 90425657
Pseudomonas infection 12.07 9.82 54 155139 14811 90458443
Sedation complication 12.06 9.82 7 155186 16937 90456317
Spontaneous haemorrhage 12.01 9.82 10 155183 723 90472531
Cardiac murmur functional 11.96 9.82 4 155189 40 90473214
Renal tubular necrosis 11.91 9.82 53 155140 14502 90458752
Dystonia 11.90 9.82 7 155186 16812 90456442
Female genital tract fistula 11.87 9.82 8 155185 17860 90455394
Atelectasis 11.85 9.82 77 155116 24332 90448922
Glomerular filtration rate abnormal 11.80 9.82 13 155180 1332 90471922
Head banging 11.79 9.82 8 155185 424 90472830
Hepatic cytolysis 11.79 9.82 92 155101 30824 90442430
Lymphocytic infiltration 11.78 9.82 12 155181 1124 90472130
Otitis media 11.78 9.82 29 155164 5841 90467413
Neutropenic infection 11.76 9.82 15 155178 1794 90471460
Degenerative aortic valve disease 11.75 9.82 6 155187 186 90473068
Vulval ulceration 11.70 9.82 8 155185 429 90472825
Genital infection 11.70 9.82 6 155187 188 90473066
Conjunctival discolouration 11.67 9.82 5 155188 103 90473151
Pulmonary embolism 11.65 9.82 300 154893 130520 90342734
Hypoalbuminaemia 11.62 9.82 56 155137 15841 90457413
Electrocardiogram QT shortened 11.61 9.82 6 155187 191 90473063
Therapeutic response decreased 11.59 9.82 98 155095 89631 90383623
Ankylosing spondylitis 11.58 9.82 4 155189 13129 90460125
Overdose 11.58 9.82 195 154998 157514 90315740
Tricuspid valve incompetence 11.56 9.82 58 155135 16673 90456581
Blood iron decreased 11.53 9.82 61 155132 17898 90455356
Blood calcium increased 11.50 9.82 46 155147 12012 90461242
Poisoning deliberate 11.47 9.82 7 155186 16479 90456775
Adult failure to thrive 11.47 9.82 6 155187 196 90473058
Enterococcal sepsis 11.46 9.82 14 155179 1602 90471652
Chorea 11.42 9.82 16 155177 2094 90471160
Maternal exposure timing unspecified 11.39 9.82 13 155180 22470 90450784
Circumoral swelling 11.39 9.82 4 155189 47 90473207
Pneumonia fungal 11.32 9.82 32 155161 6999 90466255
Generalised tonic-clonic seizure 11.32 9.82 27 155166 34876 90438378
Visual impairment 11.30 9.82 159 155034 132206 90341048
Arthritis 11.29 9.82 210 154983 167105 90306149
Bile duct stone 11.29 9.82 23 155170 4084 90469170
Roseolovirus test positive 11.29 9.82 5 155188 112 90473142
Metastases to liver 11.28 9.82 20 155173 28787 90444467
Amnesia 11.27 9.82 125 155068 108380 90364874
Vasculitis 11.27 9.82 72 155121 22621 90450633
Throat irritation 11.26 9.82 44 155149 48651 90424603
Gingival bleeding 11.26 9.82 53 155140 14850 90458404
Respiratory distress 11.25 9.82 109 155084 38837 90434417
Emphysematous cystitis 11.24 9.82 7 155186 320 90472934
Device breakage 11.20 9.82 5 155188 14039 90459215
Bacteriuria 11.18 9.82 12 155181 1194 90472060
Polyarthritis 11.17 9.82 9 155184 18341 90454913
Concussion 11.13 9.82 43 155150 11048 90462206
Metabolic alkalosis 11.12 9.82 21 155172 3528 90469726
Dermatosis 11.11 9.82 9 155184 626 90472628
Blood pressure increased 11.10 9.82 255 154938 196962 90276292
Enterococcal infection 11.08 9.82 40 155153 9951 90463303
Lower gastrointestinal haemorrhage 11.08 9.82 37 155156 8855 90464399
Chronic left ventricular failure 11.07 9.82 9 155184 629 90472625
Diffuse alopecia 11.07 9.82 12 155181 1208 90472046
Retinal haemorrhage 11.07 9.82 28 155165 5736 90467518
Granulomatous dermatitis 11.04 9.82 6 155187 212 90473042
Oral contusion 11.04 9.82 6 155187 212 90473042
Serotonin syndrome 10.99 9.82 31 155162 37856 90435398
Colitis microscopic 10.99 9.82 43 155150 11116 90462138
Urine albumin/creatinine ratio abnormal 10.97 9.82 5 155188 120 90473134
Trichiasis 10.97 9.82 5 155188 120 90473134
Influenza 10.95 9.82 170 155023 139094 90334160
Injection site mass 10.94 9.82 13 155180 22077 90451177
Campylobacter gastroenteritis 10.94 9.82 10 155183 819 90472435
Influenza like illness 10.89 9.82 87 155106 80524 90392730
Pancreatitis acute 10.86 9.82 93 155100 32022 90441232
Shunt infection 10.82 9.82 5 155188 124 90473130
Parakeratosis 10.80 9.82 7 155186 343 90472911
Muscle necrosis 10.79 9.82 10 155183 834 90472420
Burning sensation 10.79 9.82 64 155129 63388 90409866
Therapeutic response shortened 10.77 9.82 14 155179 22865 90450389
Strangury 10.75 9.82 4 155189 56 90473198
Blood albumin decreased 10.74 9.82 57 155136 16746 90456508
Pulmonary sepsis 10.74 9.82 16 155177 2215 90471039
Paraneoplastic rash 10.67 9.82 5 155188 128 90473126
Adrenal insufficiency 10.64 9.82 22 155171 29899 90443355
Maternal exposure before pregnancy 10.63 9.82 3 155190 11210 90462044
Rebound acid hypersecretion 10.62 9.82 7 155186 353 90472901
Oroticaciduria 10.61 9.82 3 155190 16 90473238
Labelled drug-drug interaction issue 10.59 9.82 16 155177 2242 90471012
Ulcer haemorrhage 10.55 9.82 18 155175 26303 90446951
Bone marrow necrosis 10.53 9.82 5 155188 132 90473122
Bronchopulmonary aspergillosis 10.48 9.82 43 155150 11355 90461899
Haemorrhage 10.46 9.82 172 155021 69197 90404057
Blood chloride decreased 10.41 9.82 29 155164 6290 90466964
Bloody peritoneal effluent 10.38 9.82 4 155189 62 90473192
Haemorrhoidal haemorrhage 10.37 9.82 26 155167 5297 90467957
Hypoperfusion 10.37 9.82 14 155179 1770 90471484
Cardiac arrest 10.35 9.82 244 154949 104691 90368563
Cross sensitivity reaction 10.34 9.82 18 155175 2839 90470415
Pain in extremity 10.33 9.82 649 154544 449880 90023374
Parathyroid hyperplasia 10.33 9.82 5 155188 138 90473116
Pylorus dilatation 10.31 9.82 3 155190 18 90473236
Device issue 10.27 9.82 22 155171 29515 90443739
Clostridium difficile infection 10.25 9.82 101 155092 36144 90437110
Amylase increased 10.25 9.82 31 155162 7041 90466213
Haemolysis 10.24 9.82 35 155158 8475 90464779
Nephropathy toxic 10.23 9.82 46 155147 12642 90460612
Chronic lymphocytic leukaemia transformation 10.21 9.82 4 155189 65 90473189
Lithiasis 10.21 9.82 4 155189 65 90473189
Blood bilirubin unconjugated decreased 10.15 9.82 4 155189 66 90473188
Hypophagia 10.09 9.82 100 155093 35837 90437417
Hypocoagulable state 9.99 9.82 13 155180 1586 90471668
Altered state of consciousness 9.98 9.82 90 155103 31442 90441812
Intracranial haematoma 9.96 9.82 7 155186 393 90472861
Dropped head syndrome 9.95 9.82 6 155187 259 90472995
Cutaneous vasculitis 9.93 9.82 31 155162 7162 90466092
Oedema mouth 9.93 9.82 16 155177 2370 90470884
Vulvovaginitis 9.92 9.82 7 155186 395 90472859
Spondylitis 9.89 9.82 6 155187 14172 90459082
Urate nephropathy 9.88 9.82 5 155188 152 90473102
Troponin increased 9.86 9.82 47 155146 13234 90460020
Odynophagia 9.86 9.82 36 155157 9007 90464247
Spontaneous haematoma 9.83 9.82 11 155182 1147 90472107
Plasma cell leukaemia 9.83 9.82 11 155182 1147 90472107

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug reaction with eosinophilia and systemic symptoms 1587.44 10.95 1590 255008 40485 42324252
Drug ineffective 826.42 10.95 1595 255003 628602 41736135
Acute kidney injury 568.04 10.95 3966 252632 363371 42001366
Off label use 426.86 10.95 2190 254408 636145 41728592
Gout 385.92 10.95 643 255955 27412 42337325
Drug abuse 382.06 10.95 82 256516 104689 42260048
Toxicity to various agents 347.77 10.95 526 256072 228610 42136127
Tumour lysis syndrome 272.23 10.95 484 256114 21747 42342990
Stevens-Johnson syndrome 262.82 10.95 476 256122 21702 42343035
Anaemia 252.93 10.95 2688 253910 277590 42087147
Renal failure 233.41 10.95 1573 255025 142153 42222584
Cytokine release syndrome 221.37 10.95 680 255918 43847 42320890
Hyperkalaemia 218.57 10.95 1012 255586 79446 42285291
General physical health deterioration 208.90 10.95 1592 255006 149654 42215083
Febrile neutropenia 196.75 10.95 1842 254756 183861 42180876
Cardiac failure 192.68 10.95 1201 255397 105655 42259082
Foetal exposure during pregnancy 189.71 10.95 29 256569 47282 42317455
Product use in unapproved indication 186.91 10.95 533 256065 183923 42180814
Toxic epidermal necrolysis 174.64 10.95 451 256147 26299 42338438
Completed suicide 155.38 10.95 212 256386 96253 42268484
Blood creatinine increased 146.81 10.95 1149 255449 108854 42255883
Treatment failure 137.94 10.95 105 256493 62519 42302218
Renal impairment 131.26 10.95 1122 255476 109106 42255631
Eosinophilia 129.20 10.95 464 256134 32435 42332302
Product monitoring error 124.02 10.95 143 256455 4280 42360457
Drug dependence 123.34 10.95 15 256583 29079 42335658
Oedema peripheral 122.29 10.95 1305 255293 134771 42229966
Intentional overdose 120.23 10.95 81 256517 51375 42313362
Hyperuricaemia 119.00 10.95 208 256390 9216 42355521
Atrial fibrillation 117.29 10.95 1321 255277 138272 42226465
Drug ineffective for unapproved indication 117.12 10.95 66 256532 46097 42318640
Chronic kidney disease 109.46 10.95 568 256030 46673 42318064
Inappropriate schedule of product administration 105.41 10.95 266 256332 95636 42269101
Dermatitis exfoliative generalised 104.57 10.95 151 256447 5673 42359064
Overdose 104.43 10.95 307 256291 104957 42259780
Toxic skin eruption 101.74 10.95 243 256355 13487 42351250
Chronic lymphocytic leukaemia 98.33 10.95 133 256465 4696 42360041
Product dose omission issue 95.92 10.95 541 256057 153824 42210913
Suicide attempt 94.42 10.95 83 256515 46017 42318720
Thrombocytopenia 91.97 10.95 1633 254965 188646 42176091
Sedation 90.53 10.95 35 256563 30440 42334297
Sepsis 89.80 10.95 1692 254906 197642 42167095
Suicidal ideation 87.91 10.95 96 256502 48065 42316672
Therapeutic product effect incomplete 86.59 10.95 186 256412 70753 42293984
Appendicolith 80.84 10.95 220 256378 13236 42351501
Injection site pain 80.59 10.95 140 256458 57658 42307079
Pyrexia 80.21 10.95 3012 253586 391030 41973707
Intentional product use issue 77.56 10.95 201 256397 71632 42293105
Premature baby 76.80 10.95 22 256576 23131 42341606
Drug resistance 75.94 10.95 57 256541 34191 42330546
Seizure 75.15 10.95 422 256176 120139 42244598
Hypotension 72.18 10.95 2046 254552 255585 42109152
Headache 71.74 10.95 1012 255586 238357 42126380
Dermatitis exfoliative 70.99 10.95 140 256458 6807 42357930
Drug withdrawal syndrome 70.52 10.95 21 256577 21528 42343209
Purpura 70.15 10.95 193 256405 11686 42353051
Right atrial hypertrophy 66.02 10.95 46 256552 691 42364046
Product use issue 65.61 10.95 239 256359 76512 42288225
Syncope 63.43 10.95 894 255704 98512 42266225
Melaena 63.30 10.95 425 256173 38321 42326416
Lymphoid tissue hypoplasia 63.19 10.95 48 256550 830 42363907
Thymus hypoplasia 61.76 10.95 47 256551 815 42363922
Aggression 61.54 10.95 107 256491 44056 42320681
No adverse event 60.56 10.95 88 256510 38933 42325804
Blood urea increased 59.89 10.95 370 256228 32423 42332314
Blood lactate dehydrogenase increased 59.30 10.95 312 256286 25769 42338968
Splenomegaly 58.26 10.95 230 256368 16817 42347920
Ventricular enlargement 57.40 10.95 41 256557 642 42364095
Myelosuppression 57.32 10.95 97 256501 40364 42324373
Inferior vena cava dilatation 57.19 10.95 44 256554 776 42363961
Anxiety 56.78 10.95 449 256149 118111 42246626
Appendicitis 56.43 10.95 260 256338 20353 42344384
Plasma cell myeloma 56.40 10.95 484 256114 47094 42317643
Infective exacerbation of chronic obstructive airways disease 55.78 10.95 65 256533 1968 42362769
Respiratory depression 55.50 10.95 22 256576 18846 42345891
Aortic valve stenosis 55.00 10.95 79 256519 2953 42361784
Pain 54.74 10.95 1092 255506 243756 42120981
Hyperphosphataemia 53.26 10.95 186 256412 12818 42351919
Synovitis 53.12 10.95 14 256584 15553 42349184
Depression 52.75 10.95 423 256175 110940 42253797
Rash maculo-papular 51.77 10.95 395 256203 37108 42327629
Face oedema 51.32 10.95 190 256408 13476 42351261
Blood phosphorus increased 51.17 10.95 179 256419 12346 42352391
Gouty arthritis 51.10 10.95 49 256549 1178 42363559
Psychotic disorder 50.29 10.95 61 256537 29147 42335590
Hyponatraemia 50.08 10.95 874 255724 100588 42264149
Haematoma 49.81 10.95 314 256284 27709 42337028
Cardiogenic shock 49.54 10.95 376 256222 35264 42329473
Therapy partial responder 47.45 10.95 31 256567 19990 42344747
Dyspnoea 46.87 10.95 3177 253421 439444 41925293
Tumour flare 46.06 10.95 45 256553 1108 42363629
Therapy non-responder 45.70 10.95 166 256432 53193 42311544
Serotonin syndrome 45.54 10.95 53 256545 25792 42338945
Frequent bowel movements 44.49 10.95 38 256560 21369 42343368
Pulmonary function test abnormal 44.26 10.95 67 256531 2627 42362110
Epistaxis 43.82 10.95 604 255994 66222 42298515
Acute myeloid leukaemia 43.76 10.95 256 256342 22000 42342737
Ascites 42.92 10.95 526 256072 56152 42308585
Neuroleptic malignant syndrome 42.37 10.95 40 256558 21432 42343305
Bronchial secretion retention 41.80 10.95 50 256548 1557 42363180
Ventricular fibrillation 40.86 10.95 316 256282 29807 42334930
Labelled drug-drug interaction medication error 40.79 10.95 194 256404 15388 42349349
IgM nephropathy 40.40 10.95 19 256579 126 42364611
Erythema multiforme 40.25 10.95 142 256456 9835 42354902
Nightmare 40.21 10.95 55 256543 24957 42339780
Multiple organ dysfunction syndrome 39.66 10.95 812 255786 96223 42268514
Insomnia 39.35 10.95 489 256109 117764 42246973
Product prescribing error 38.86 10.95 280 256318 25832 42338905
Disseminated aspergillosis 38.86 10.95 50 256548 1680 42363057
Febrile infection 38.74 10.95 64 256534 2707 42362030
Blood pressure fluctuation 38.58 10.95 64 256534 26844 42337893
Arthralgia 38.48 10.95 941 255657 204297 42160440
Nasopharyngitis 38.41 10.95 322 256276 83674 42281063
Irritability 38.41 10.95 69 256529 28059 42336678
Rales 38.30 10.95 153 256445 11247 42353490
Bronchial wall thickening 38.18 10.95 44 256554 1316 42363421
Accidental exposure to product 37.93 10.95 40 256558 20353 42344384
Degenerative mitral valve disease 37.83 10.95 23 256575 270 42364467
Impaired quality of life 37.82 10.95 19 256579 14158 42350579
Device interaction 37.74 10.95 30 256568 556 42364181
Normocytic anaemia 37.66 10.95 73 256525 3504 42361233
Bacterial infection 37.56 10.95 292 256306 27587 42337150
Cardiac failure chronic 37.33 10.95 135 256463 9466 42355271
Poisoning 37.30 10.95 21 256577 14678 42350059
Haemoglobin decreased 37.26 10.95 1053 255545 131418 42233319
Loss of personal independence in daily activities 36.95 10.95 164 256434 49652 42315085
Migraine 36.85 10.95 60 256538 25354 42339383
Substance abuse 36.76 10.95 5 256593 8900 42355837
Right ventricular hypertrophy 36.67 10.95 46 256552 1506 42363231
Accidental overdose 36.48 10.95 72 256526 28258 42336479
Neutropenic sepsis 36.41 10.95 191 256407 15755 42348982
Thrombotic microangiopathy 36.26 10.95 22 256576 14760 42349977
Impaired work ability 35.72 10.95 14 256584 12077 42352660
Therapeutic drug monitoring analysis incorrectly performed 35.64 10.95 23 256575 302 42364435
Condition aggravated 34.80 10.95 1252 255346 259502 42105235
Forced expiratory volume decreased 34.75 10.95 3 256595 7627 42357110
Abnormal behaviour 34.26 10.95 67 256531 26384 42338353
Colitis ulcerative 34.16 10.95 66 256532 26109 42338628
Intentional self-injury 34.09 10.95 25 256573 15177 42349560
Acute graft versus host disease in skin 33.60 10.95 3 256595 7421 42357316
Withdrawal syndrome 33.52 10.95 24 256574 14751 42349986
Glomerular filtration rate abnormal 33.46 10.95 39 256559 1181 42363556
Activated partial thromboplastin time prolonged 33.28 10.95 186 256412 15717 42349020
Cardiac failure congestive 32.92 10.95 710 255888 84892 42279845
Dehydration 32.71 10.95 1100 255498 140667 42224070
Hallucination, auditory 32.62 10.95 25 256573 14839 42349898
Intentional product misuse 32.19 10.95 229 256369 61671 42303066
Platelet count decreased 31.90 10.95 1075 255523 137506 42227231
Gastrointestinal haemorrhage 31.84 10.95 792 255806 96934 42267803
Dyskinesia 31.44 10.95 66 256532 25324 42339413
International normalised ratio increased 31.42 10.95 435 256163 47733 42317004
Exercise tolerance decreased 31.40 10.95 94 256504 5972 42358765
Diastolic dysfunction 31.35 10.95 103 256495 6880 42357857
Pelvic mass 31.32 10.95 19 256579 222 42364515
Malignant neoplasm progression 31.10 10.95 462 256136 107938 42256799
Pathogen resistance 31.06 10.95 15 256583 11435 42353302
Rhabdomyolysis 30.93 10.95 650 255948 77369 42287368
Pleural effusion 30.64 10.95 784 255814 96382 42268355
Hypercreatininaemia 30.61 10.95 26 256572 531 42364206
Coma 30.41 10.95 193 256405 53361 42311376
Dyspnoea exertional 30.37 10.95 447 256151 49701 42315036
Bradycardia 30.34 10.95 701 255897 84783 42279954
Device leakage 30.23 10.95 12 256586 10273 42354464
Hyperhidrosis 30.21 10.95 374 256224 90138 42274599
Systemic infection 30.17 10.95 84 256514 5121 42359616
Electrolyte imbalance 30.01 10.95 191 256407 16910 42347827
Gouty tophus 29.94 10.95 17 256581 174 42364563
Post transplant lymphoproliferative disorder 29.64 10.95 9 256589 9111 42355626
Hospitalisation 29.20 10.95 296 256302 74034 42290703
Therapeutic product effect decreased 28.97 10.95 129 256469 39021 42325716
Respiratory arrest 28.82 10.95 82 256516 28342 42336395
Low birth weight baby 28.64 10.95 12 256586 9943 42354794
Maternal exposure during pregnancy 28.61 10.95 4 256594 6974 42357763
Intercepted product preparation error 28.56 10.95 5 256593 7384 42357353
Electrolyte depletion 28.40 10.95 19 256579 266 42364471
Agitation 28.31 10.95 249 256349 64065 42300672
Atrial enlargement 28.28 10.95 28 256570 701 42364036
Blood electrolytes abnormal 28.27 10.95 33 256565 1001 42363736
Immune reconstitution inflammatory syndrome 27.96 10.95 13 256585 10130 42354607
Diabetic ketoacidosis 27.82 10.95 58 256540 22309 42342428
Therapeutic drug monitoring analysis not performed 27.63 10.95 25 256573 557 42364180
Asthenia 27.62 10.95 2004 254594 278789 42085948
Generalised tonic-clonic seizure 27.56 10.95 75 256523 26304 42338433
Erysipelas 27.49 10.95 92 256506 6204 42358533
Systemic lupus erythematosus 27.21 10.95 11 256587 9313 42355424
Hepatic vein dilatation 26.95 10.95 17 256581 214 42364523
Device issue 26.85 10.95 25 256573 13484 42351253
Rheumatoid arthritis 26.72 10.95 148 256450 42292 42322445
Analgesic therapy 26.45 10.95 93 256505 6431 42358306
Haematuria 26.42 10.95 492 256106 57307 42307430
Death 26.34 10.95 2461 254137 468724 41896013
Cutaneous vasculitis 26.28 10.95 96 256502 6764 42357973
Pneumonia aspiration 26.17 10.95 185 256413 49893 42314844
Epididymitis 26.14 10.95 57 256541 2977 42361760
Tinnitus 26.13 10.95 88 256510 28850 42335887
Chronic graft versus host disease 25.80 10.95 3 256595 6022 42358715
Multimorbidity 25.78 10.95 30 256568 907 42363830
Mental disorder 25.74 10.95 43 256555 17986 42346751
Iron deficiency 25.61 10.95 133 256465 10928 42353809
Graft versus host disease 25.59 10.95 24 256574 12901 42351836
Soft tissue mass 25.53 10.95 31 256567 981 42363756
Differentiation syndrome 25.51 10.95 42 256556 1771 42362966
Alcohol poisoning 25.48 10.95 7 256591 7567 42357170
Rheumatoid factor negative 25.48 10.95 31 256567 983 42363754
Drug interaction 25.48 10.95 1901 254697 265098 42099639
Atrial septal defect 25.40 10.95 8 256590 7911 42356826
Gravitational oedema 25.28 10.95 26 256572 682 42364055
Blood lactic acid 25.09 10.95 19 256579 327 42364410
Restlessness 25.03 10.95 91 256507 29158 42335579
Drug dose omission by device 25.03 10.95 3 256595 5883 42358854
Poisoning deliberate 24.97 10.95 15 256583 10119 42354618
Blood potassium increased 24.89 10.95 194 256404 18342 42346395
Depressed mood 24.79 10.95 66 256532 23318 42341419
Renal function test abnormal 24.72 10.95 56 256542 3001 42361736
Injection site swelling 24.68 10.95 40 256558 16933 42347804
Musculoskeletal stiffness 24.39 10.95 226 256372 57539 42307198
Hypertrophy 24.28 10.95 22 256576 491 42364246
Ejection fraction decreased 24.26 10.95 221 256377 21866 42342871
Mantle cell lymphoma 24.21 10.95 37 256561 1463 42363274
Obstruction 24.16 10.95 56 256542 3047 42361690
Needle fatigue 24.08 10.95 33 256565 1180 42363557
Blood uric acid increased 23.88 10.95 168 256430 15379 42349358
Benign prostatic hyperplasia 23.82 10.95 212 256386 20840 42343897
Illness 23.77 10.95 74 256524 24856 42339881
Acute graft versus host disease 23.48 10.95 10 256588 8205 42356532
Therapeutic response decreased 23.34 10.95 129 256469 36883 42327854
Hypocalcaemia 23.26 10.95 281 256317 29892 42334845
Glomerular filtration rate decreased 23.00 10.95 173 256425 16178 42348559
Neurological symptom 22.97 10.95 16 256582 9975 42354762
Drug level above therapeutic 22.82 10.95 4 256594 5902 42358835
Transplant rejection 22.74 10.95 29 256569 13559 42351178
Oligoasthenozoospermia 22.68 10.95 7 256591 10 42364727
Anger 22.61 10.95 27 256571 12991 42351746
Drug effective for unapproved indication 22.56 10.95 6 256592 6627 42358110
Drug therapy 22.55 10.95 87 256511 6293 42358444
Metabolic acidosis 22.52 10.95 438 256160 51420 42313317
Multiple-drug resistance 22.43 10.95 8 256590 7314 42357423
Dialysis 22.36 10.95 136 256462 11850 42352887
Pulmonary vascular disorder 22.31 10.95 24 256574 664 42364073
Drug intolerance 22.30 10.95 345 256253 80079 42284658
Narrow anterior chamber angle 22.26 10.95 12 256586 110 42364627
Nicotine dependence 22.16 10.95 24 256574 669 42364068
Immune effector cell-associated neurotoxicity syndrome 22.07 10.95 114 256484 9347 42355390
Syringe issue 22.03 10.95 12 256586 8544 42356193
Hypopnoea 21.88 10.95 10 256588 7872 42356865
Psoriatic arthropathy 21.82 10.95 77 256521 24890 42339847
Small for dates baby 21.62 10.95 3 256595 5260 42359477
Chest X-ray abnormal 21.60 10.95 68 256530 4440 42360297
Orthostatic hypotension 21.55 10.95 280 256318 30290 42334447
Mucormycosis 21.55 10.95 8 256590 7135 42357602
Abdominal discomfort 21.49 10.95 321 256277 74934 42289803
Obsessive-compulsive disorder 21.29 10.95 7 256591 6736 42358001
Blood calcium increased 21.22 10.95 104 256494 8350 42356387
Arrhythmia 21.22 10.95 351 256247 39966 42324771
Activated partial thromboplastin time shortened 21.16 10.95 20 256578 472 42364265
Sleep disorder due to a general medical condition 21.08 10.95 46 256552 17407 42347330
Vascular purpura 21.07 10.95 43 256555 2143 42362594
Asphyxia 20.97 10.95 12 256586 8314 42356423
Base excess decreased 20.93 10.95 14 256584 196 42364541
Extrapyramidal disorder 20.88 10.95 42 256556 16370 42348367
Organic brain syndrome 20.86 10.95 17 256581 327 42364410
Sinusitis 20.85 10.95 183 256415 47109 42317628
Hypertonic bladder 20.82 10.95 45 256553 2336 42362401
Product storage error 20.55 10.95 22 256576 11118 42353619
Chronic myeloid leukaemia 20.54 10.95 46 256552 2446 42362291
Neuritis 20.46 10.95 6 256592 6214 42358523
Poor venous access 20.45 10.95 9 256589 7243 42357494
Sleep disorder therapy 20.40 10.95 89 256509 6805 42357932
Gingival pain 20.34 10.95 13 256585 8481 42356256
Dermatitis allergic 20.33 10.95 103 256495 8380 42356357
Hypophosphataemia 20.25 10.95 204 256394 20741 42343996
Aptyalism 20.23 10.95 18 256580 392 42364345
Injection site reaction 20.20 10.95 40 256558 15681 42349056
Haemodialysis 20.15 10.95 118 256480 10142 42354595
Bronchospasm 20.04 10.95 29 256569 12856 42351881
Adenovirus infection 19.92 10.95 8 256590 6801 42357936
Blood uric acid decreased 19.88 10.95 19 256579 455 42364282
Somnolence 19.82 10.95 673 255925 140432 42224305
Feeling abnormal 19.81 10.95 298 256300 69488 42295249
Tooth deposit 19.80 10.95 10 256588 79 42364658
Genital erosion 19.67 10.95 16 256582 307 42364430
Serum ferritin abnormal 19.67 10.95 15 256583 261 42364476
Lymphadenopathy 19.65 10.95 296 256302 33069 42331668
Anti-neutrophil cytoplasmic antibody positive vasculitis 19.65 10.95 34 256564 1494 42363243
Intestinal angioedema 19.50 10.95 14 256584 221 42364516
Electrocardiogram abnormal 19.49 10.95 116 256482 10029 42354708
Monoparesis 19.41 10.95 50 256548 2910 42361827
Oesophageal perforation 19.32 10.95 30 256568 1203 42363534
Eye injury 19.25 10.95 27 256571 987 42363750
Wrong technique in product usage process 19.23 10.95 164 256434 42471 42322266
Pancytopenia 19.23 10.95 880 255718 116863 42247874
Escherichia sepsis 19.20 10.95 77 256521 5670 42359067
Incorrect dose administered 19.17 10.95 215 256383 52759 42311978
Varicose vein 19.10 10.95 34 256564 1528 42363209
Periarthritis calcarea 19.09 10.95 10 256588 86 42364651
Acne 19.05 10.95 33 256565 13611 42351126
Pneumothorax 19.01 10.95 75 256523 23468 42341269
Gait spastic 18.97 10.95 32 256566 1377 42363360
SJS-TEN overlap 18.96 10.95 22 256576 663 42364074
Brain oedema 18.93 10.95 44 256554 16283 42348454
Mydriasis 18.93 10.95 15 256583 8755 42355982
Therapeutic response shortened 18.73 10.95 33 256565 13521 42351216
Articular calcification 18.70 10.95 10 256588 90 42364647
Coating in mouth 18.70 10.95 10 256588 90 42364647
Liver palpable 18.65 10.95 15 256583 283 42364454
Lacunar stroke 18.65 10.95 15 256583 283 42364454
Atrial flutter 18.64 10.95 172 256426 17079 42347658
Anaphylactic reaction 18.58 10.95 166 256432 42577 42322160
C-reactive protein abnormal 18.57 10.95 17 256581 9244 42355493
Oroantral fistula 18.56 10.95 13 256585 197 42364540
Injection site erythema 18.52 10.95 61 256537 20134 42344603
Subacute hepatic failure 18.33 10.95 10 256588 94 42364643
Oedema 18.31 10.95 426 256172 51575 42313162
Blood urea abnormal 18.27 10.95 28 256570 1110 42363627
Body temperature decreased 18.24 10.95 37 256561 14376 42350361
Cardio-respiratory arrest 18.19 10.95 246 256352 58390 42306347
Abdominal distension 18.19 10.95 563 256035 71172 42293565
Adrenal insufficiency 18.16 10.95 56 256542 18868 42345869
Heart rate increased 18.16 10.95 219 256379 53036 42311701
Aortic stenosis 18.11 10.95 102 256496 8643 42356094
Exposure to toxic agent 18.05 10.95 4 256594 5000 42359737
Device malfunction 17.97 10.95 29 256569 12298 42352439
Human herpesvirus 6 infection 17.97 10.95 44 256554 2481 42362256
Prostate cancer recurrent 17.89 10.95 27 256571 1056 42363681
Blood pressure increased 17.81 10.95 472 256126 101456 42263281
Rash maculovesicular 17.81 10.95 8 256590 47 42364690
Hypocoagulable state 17.80 10.95 26 256572 987 42363750
Malignant spinal cord compression 17.75 10.95 11 256587 134 42364603
Hypoglycaemia 17.71 10.95 479 256119 59375 42305362
Hypomagnesaemia 17.66 10.95 255 256343 28233 42336504
Relapsing-remitting multiple sclerosis 17.59 10.95 32 256566 1463 42363274
Pruritus allergic 17.55 10.95 16 256582 360 42364377
Abnormal clotting factor 17.52 10.95 9 256589 74 42364663
Intestinal haemorrhage 17.49 10.95 58 256540 3893 42360844
Oxygen saturation decreased 17.42 10.95 279 256319 64408 42300329
Myelofibrosis 17.41 10.95 36 256562 1811 42362926
Treatment noncompliance 17.40 10.95 144 256454 37528 42327209
Alopecia 17.40 10.95 104 256494 29172 42335565
Jugular vein distension 17.33 10.95 21 256577 663 42364074
Epidermolysis 17.32 10.95 18 256580 478 42364259
Dependence on oxygen therapy 17.30 10.95 13 256585 221 42364516
Nephrogenic anaemia 17.28 10.95 44 256554 2542 42362195
Diabetes mellitus 17.26 10.95 479 256119 59608 42305129
Conjunctivitis allergic 17.21 10.95 7 256591 5904 42358833
Heart rate decreased 17.17 10.95 139 256459 36393 42328344
Schizophrenia 17.16 10.95 23 256575 10527 42354210
Azotaemia 17.03 10.95 76 256522 5868 42358869
Post-traumatic amnestic disorder 17.02 10.95 8 256590 53 42364684
Lymphocytopenia neonatal 17.01 10.95 6 256592 16 42364721
Glomerular filtration rate 17 10.95 10 256588 110 42364627
Myasthenia gravis 16.98 10.95 160 256438 15977 42348760
Drug therapeutic incompatibility 16.92 10.95 10 256588 111 42364626
Paranoia 16.92 10.95 37 256561 13989 42350748
Constipation 16.91 10.95 1164 255434 161127 42203610
Unresponsive to stimuli 16.90 10.95 115 256483 31288 42333449
COVID-19 16.75 10.95 551 256047 115397 42249340
Sexual dysfunction 16.73 10.95 10 256588 6765 42357972
Renal atrophy 16.70 10.95 29 256569 1278 42363459
Platelet distribution width increased 16.69 10.95 11 256587 150 42364587
Ankylosing spondylitis 16.62 10.95 11 256587 7045 42357692
Cardioactive drug level increased 16.55 10.95 34 256564 1703 42363034
Folate deficiency 16.52 10.95 34 256564 1705 42363032
Entropion 16.48 10.95 4 256594 0 42364737
Crying 16.42 10.95 9 256589 6385 42358352
Needle issue 16.36 10.95 17 256581 8710 42356027
Bradyarrhythmia 16.33 10.95 44 256554 2631 42362106
Subcutaneous haematoma 16.27 10.95 26 256572 1069 42363668
Retinal disorder 16.24 10.95 27 256571 1148 42363589
Dizziness 16.24 10.95 1726 254872 247528 42117209
Cardiac aneurysm 16.13 10.95 26 256572 1077 42363660
Nodule 16.01 10.95 32 256566 12502 42352235
Increased appetite 15.97 10.95 18 256580 8888 42355849
Prostate cancer 15.83 10.95 182 256416 44461 42320276
Gastrointestinal adenocarcinoma 15.76 10.95 8 256590 64 42364673
Product quality issue 15.72 10.95 55 256543 17827 42346910
Antacid therapy 15.60 10.95 63 256535 4654 42360083
Underdose 15.52 10.95 50 256548 16616 42348121
Neonatal respiratory distress syndrome 15.51 10.95 4 256594 4509 42360228
Influenza like illness 15.49 10.95 120 256478 31720 42333017
Cardiovascular insufficiency 15.38 10.95 34 256564 1792 42362945
Cardiac autonomic neuropathy 15.25 10.95 8 256590 69 42364668
Abnormal loss of weight 15.23 10.95 65 256533 4922 42359815
Steroid dependence 15.14 10.95 11 256587 6711 42358026
Hypervolaemia 15.14 10.95 209 256389 22916 42341821
Diverticulum intestinal 15.12 10.95 66 256532 5047 42359690
Graft versus host disease in gastrointestinal tract 15.12 10.95 6 256592 5137 42359600
Strangury 15.07 10.95 10 256588 138 42364599
Pulmonary hypertension 15.02 10.95 212 256386 23357 42341380
Copper deficiency 15.01 10.95 6 256592 25 42364712
Speech disorder 15.01 10.95 108 256490 29013 42335724
Decreased gait velocity 14.99 10.95 11 256587 180 42364557
Rash morbilliform 14.98 10.95 57 256541 4096 42360641
Weight decreased 14.94 10.95 1064 255534 206884 42157853
Lip erosion 14.94 10.95 19 256579 631 42364106
Gastritis erosive 14.92 10.95 78 256520 6425 42358312
Iridocele 14.82 10.95 6 256592 26 42364711
Mantle cell lymphoma refractory 14.78 10.95 9 256589 106 42364631
Antineutrophil cytoplasmic antibody positive 14.75 10.95 4 256594 4361 42360376
Adrenal cyst 14.74 10.95 11 256587 185 42364552
Hypersensitivity vasculitis 14.70 10.95 48 256550 3196 42361541
Ichthyosis acquired 14.55 10.95 5 256593 12 42364725
Anticoagulant therapy 14.55 10.95 60 256538 4475 42360262
Nervousness 14.49 10.95 38 256560 13494 42351243
Nasal congestion 14.44 10.95 111 256487 29390 42335347
Respiratory fatigue 14.42 10.95 9 256589 111 42364626
Drooling 14.41 10.95 4 256594 4295 42360442
Peripheral arterial occlusive disease 14.32 10.95 80 256518 6758 42357979
Status epilepticus 14.32 10.95 47 256551 15531 42349206
Polyomavirus-associated nephropathy 14.28 10.95 8 256590 5607 42359130
Anaphylactic shock 14.26 10.95 83 256515 23434 42341303
Helicobacter test positive 14.26 10.95 21 256577 803 42363934
Rebound effect 14.26 10.95 14 256584 7365 42357372
Cutaneous T-cell lymphoma stage I 14.22 10.95 9 256589 114 42364623
Jaundice cholestatic 14.18 10.95 66 256532 5187 42359550
Fistula 14.18 10.95 16 256582 7896 42356841
Alanine aminotransferase abnormal 14.16 10.95 6 256592 4938 42359799
Dyspepsia 14.12 10.95 170 256428 41182 42323555
Arrhythmia supraventricular 13.96 10.95 29 256569 1464 42363273
Amnesia 13.92 10.95 107 256491 28330 42336407
Peptic ulcer haemorrhage 13.89 10.95 19 256579 678 42364059
Blood chloride increased 13.82 10.95 50 256548 3506 42361231
Enterococcus test positive 13.77 10.95 31 256567 1654 42363083
Portal vein flow decreased 13.75 10.95 5 256593 15 42364722
Carcinoma in situ of skin 13.68 10.95 8 256590 87 42364650
Tricuspid valve incompetence 13.66 10.95 114 256484 10999 42353738
Mucosal necrosis 13.60 10.95 8 256590 88 42364649
Mood swings 13.60 10.95 20 256578 8806 42355931
Dyspnoea at rest 13.46 10.95 56 256542 4193 42360544
Cardiotoxicity 13.40 10.95 15 256583 7430 42357307
Weight increased 13.36 10.95 523 256075 107460 42257277
Mitral valve incompetence 13.34 10.95 155 256443 16334 42348403
Injection site haemorrhage 13.31 10.95 32 256566 11704 42353033
Parosmia 13.30 10.95 16 256582 7675 42357062
Neck pain 13.29 10.95 116 256482 29898 42334839
Uveitis 13.29 10.95 22 256576 9236 42355501
Nephrocalcinosis 13.23 10.95 20 256578 783 42363954
Fear 13.16 10.95 29 256569 10936 42353801
Lens dislocation 13.16 10.95 9 256589 131 42364606
Eosinophilic pustular folliculitis 12.99 10.95 6 256592 38 42364699
Cytomegalovirus nephritis 12.98 10.95 9 256589 134 42364603
Hypercalcaemia 12.98 10.95 166 256432 17892 42346845
Serum ferritin increased 12.89 10.95 81 256517 7138 42357599
Urticaria 12.89 10.95 343 256255 73693 42291044
C-reactive protein increased 12.87 10.95 486 256112 63074 42301663
Trichiasis 12.85 10.95 4 256594 6 42364731
Thrombin time prolonged 12.83 10.95 10 256588 180 42364557
Blood creatine increased 12.82 10.95 68 256530 5632 42359105
Discomfort 12.77 10.95 94 256504 25125 42339612
Age-related macular degeneration 12.73 10.95 13 256585 338 42364399
Flushing 12.73 10.95 152 256446 36876 42327861
Vision blurred 12.72 10.95 237 256361 53462 42311275
Metastases to bone 12.72 10.95 46 256552 14763 42349974
Left ventricular enlargement 12.70 10.95 20 256578 812 42363925
Prothrombin time prolonged 12.65 10.95 99 256499 9370 42355367
Osteochondrosis 12.63 10.95 27 256571 1391 42363346
Implant site inflammation 12.60 10.95 8 256590 102 42364635
Xerosis 12.59 10.95 21 256577 895 42363842
Disturbance in attention 12.54 10.95 117 256481 29749 42334988
Hospice care 12.50 10.95 91 256507 8422 42356315
Hyperamylasaemia 12.49 10.95 17 256581 604 42364133
White blood cell count decreased 12.42 10.95 797 255801 109599 42255138
Psychomotor skills impaired 12.41 10.95 8 256590 5196 42359541
Blood pressure ambulatory increased 12.38 10.95 7 256591 71 42364666
Troponin increased 12.37 10.95 172 256426 18890 42345847
Inflammation scan 12.36 10.95 3 256595 0 42364737
Oesophageal mucosal blister 12.36 10.95 3 256595 0 42364737
Persistent generalised lymphadenopathy 12.36 10.95 3 256595 0 42364737
HLA-B*5801 assay positive 12.36 10.95 3 256595 0 42364737
Surgical vascular shunt 12.36 10.95 3 256595 0 42364737
Nocardiosis 12.35 10.95 8 256590 5182 42359555
Influenza 12.19 10.95 283 256315 61892 42302845
Paroxysmal arrhythmia 12.13 10.95 4 256594 8 42364729
Microcytic anaemia 12.07 10.95 43 256555 2992 42361745
Microphthalmos 12.07 10.95 10 256588 197 42364540
Transfusion reaction 12.07 10.95 21 256577 927 42363810
Parkinsonism 12.02 10.95 29 256569 10594 42354143
Hepatitis C 12.00 10.95 27 256571 10106 42354631
Eosinophilic granulomatosis with polyangiitis 11.96 10.95 21 256577 8617 42356120
Retinitis viral 11.93 10.95 9 256589 154 42364583
Pulmonary sarcoidosis 11.89 10.95 19 256579 781 42363956
Xanthopsia 11.88 10.95 9 256589 155 42364582
Bone marrow reticulin fibrosis 11.88 10.95 9 256589 155 42364582
Cardiac failure acute 11.87 10.95 130 256468 13503 42351234
Injection site bruising 11.86 10.95 33 256565 11492 42353245
Drug screen positive 11.85 10.95 5 256593 4126 42360611
Skin oedema 11.85 10.95 18 256580 708 42364029
Light chain disease 11.83 10.95 9 256589 156 42364581
Aspergillus infection 11.82 10.95 52 256546 15785 42348952
Disease risk factor 11.82 10.95 6 256592 48 42364689
Vomiting 11.80 10.95 1546 255052 288177 42076560
Cellulitis 11.78 10.95 468 256130 61117 42303620
Acute cutaneous lupus erythematosus 11.75 10.95 7 256591 79 42364658
Lipase increased 11.74 10.95 106 256492 10460 42354277
Arteriospasm coronary 11.69 10.95 7 256591 4731 42360006
Gamma-glutamyltransferase increased 11.68 10.95 267 256331 32230 42332507
Epilepsy 11.65 10.95 101 256497 26070 42338667
Pneumonia 11.61 10.95 2787 253811 419362 41945375
BK virus infection 11.59 10.95 22 256576 8762 42355975
Rash 11.58 10.95 1867 254731 275087 42089650
Pain in extremity 11.57 10.95 766 255832 149838 42214899
Full blood count abnormal 11.54 10.95 248 256350 29628 42335109
Rhinorrhoea 11.51 10.95 129 256469 31665 42333072
Drug hypersensitivity 11.51 10.95 485 256113 98904 42265833
Eyelid oedema 11.51 10.95 66 256532 5629 42359108
Tenosynovitis 11.50 10.95 7 256591 4688 42360049
Drug level decreased 11.48 10.95 27 256571 9950 42354787
Hepatosplenomegaly 11.46 10.95 57 256541 4603 42360134
Apparent death 11.45 10.95 4 256594 3704 42361033
Hypoaesthesia 11.44 10.95 335 256263 71128 42293609
Aplasia pure red cell 11.34 10.95 78 256520 7088 42357649
Stenosis 11.30 10.95 33 256565 2068 42362669
Viral infection 11.29 10.95 84 256514 22399 42342338
Systolic dysfunction 11.29 10.95 42 256556 2986 42361751
Multiple sclerosis relapse 11.16 10.95 46 256552 14218 42350519
Adenocarcinoma of appendix 11.16 10.95 8 256590 126 42364611
Drug tolerance 11.15 10.95 3 256595 3287 42361450
Blindness 11.15 10.95 63 256535 17915 42346822
Graft versus host disease in skin 11.14 10.95 9 256589 5203 42359534
Pancreatic duct dilatation 11.10 10.95 7 256591 88 42364649
Cardiac ventricular disorder 11.09 10.95 11 256587 276 42364461
Sopor 11.08 10.95 125 256473 13077 42351660
Emotional disorder 11.07 10.95 13 256585 6301 42358436
Myocardial ischaemia 11.01 10.95 159 256439 17603 42347134
Hepatitis acute 11.00 10.95 92 256506 8883 42355854
Coronary artery stenosis 10.97 10.95 103 256495 10276 42354461

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug reaction with eosinophilia and systemic symptoms 4401.87 9.79 2949 358005 79146 110149199
Acute kidney injury 2193.96 9.79 5738 355216 629692 109598653
Febrile neutropenia 974.29 9.79 2746 358208 314021 109914324
Drug ineffective 951.34 9.79 2240 358714 1518300 108710045
Anaemia 892.57 9.79 3841 357113 543245 109685100
Toxic epidermal necrolysis 804.26 9.79 959 359995 55768 110172577
Renal failure 770.85 9.79 2039 358915 224535 110003810
Cytokine release syndrome 746.94 9.79 1030 359924 69276 110159069
Hyperkalaemia 746.76 9.79 1478 359476 134318 110094027
Stevens-Johnson syndrome 698.20 9.79 813 360141 46088 110182257
Gout 659.91 9.79 701 360253 35865 110192480
Pemphigus 624.52 9.79 16 360938 214554 110013791
Tumour lysis syndrome 617.96 9.79 625 360329 30176 110198169
Systemic lupus erythematosus 613.33 9.79 60 360894 254278 109974067
Maternal exposure during pregnancy 589.46 9.79 70 360884 254813 109973532
Glossodynia 584.20 9.79 35 360919 221969 110006376
Hand deformity 570.32 9.79 36 360918 218470 110009875
Cardiac failure 569.75 9.79 1620 359334 186006 110042339
Synovitis 548.66 9.79 113 360841 273979 109954366
Alopecia 516.65 9.79 273 360681 364480 109863865
Renal impairment 505.42 9.79 1557 359397 186888 110041457
Sepsis 483.39 9.79 2233 358721 325113 109903232
Blood creatinine increased 473.74 9.79 1493 359461 181396 110046949
Duodenal ulcer perforation 455.70 9.79 32 360922 177668 110050677
Thrombocytopenia 440.67 9.79 2276 358678 346609 109881736
Pericarditis 435.04 9.79 92 360862 219022 110009323
Atrial fibrillation 433.16 9.79 1688 359266 227954 110000391
Helicobacter infection 432.97 9.79 45 360909 181832 110046513
Irritable bowel syndrome 428.66 9.79 27 360927 164188 110064157
Arthropathy 425.40 9.79 203 360751 287319 109941026
Joint swelling 420.15 9.79 496 360458 442349 109785996
Rheumatoid factor positive 412.02 9.79 3 360951 131637 110096708
Psoriatic arthropathy 389.82 9.79 83 360871 196678 110031667
Eosinophilia 387.43 9.79 686 360268 57250 110171095
Therapeutic product effect decreased 382.61 9.79 159 360795 244157 109984188
Exposure during pregnancy 377.23 9.79 50 360904 167374 110060971
Treatment failure 375.82 9.79 219 360735 277015 109951330
Muscle injury 370.98 9.79 22 360932 140785 110087560
Pain 365.20 9.79 1740 359214 953215 109275130
Rheumatoid arthritis 355.99 9.79 274 360680 299339 109929006
Discomfort 353.92 9.79 129 360825 214578 110013767
Abdominal discomfort 343.54 9.79 470 360484 393388 109834957
Hypotension 343.41 9.79 2899 358055 520950 109707395
Folliculitis 341.93 9.79 66 360888 167587 110060758
Nasopharyngitis 337.57 9.79 477 360477 393884 109834461
Melaena 331.34 9.79 709 360245 68048 110160297
Drug interaction 330.99 9.79 2774 358180 497409 109730936
Rash maculo-papular 326.70 9.79 738 360216 73484 110154861
Fibromyalgia 320.85 9.79 81 360873 170828 110057517
Wound 316.58 9.79 186 360768 234251 109994094
Sinusitis 315.10 9.79 302 360652 296386 109931959
Chronic kidney disease 314.24 9.79 739 360215 75552 110152793
Off label use 309.19 9.79 3272 357682 1496913 108731432
C-reactive protein abnormal 293.92 9.79 38 360916 129657 110098688
Toxic skin eruption 293.46 9.79 404 360550 27111 110201234
Sleep disorder due to general medical condition, insomnia type 286.11 9.79 14 360940 105629 110122716
Lip dry 281.94 9.79 10 360944 100073 110128272
Arthralgia 280.80 9.79 1450 359504 778182 109450163
Hepatic enzyme increased 280.69 9.79 382 360572 320510 109907835
Impaired healing 262.86 9.79 158 360796 196559 110031786
Syncope 259.37 9.79 1327 359627 201209 110027136
Infusion related reaction 258.30 9.79 535 360419 380627 109847718
Headache 257.48 9.79 1755 359199 880622 109347723
Pyrexia 252.57 9.79 4224 356730 894041 109334304
Facet joint syndrome 249.48 9.79 17 360937 96811 110131534
Hyponatraemia 248.69 9.79 1382 359572 216271 110012074
Drug intolerance 248.22 9.79 604 360350 405908 109822437
Intentional product use issue 246.52 9.79 267 360687 247639 109980706
Drug hypersensitivity 245.28 9.79 717 360237 453373 109774972
General physical health deterioration 245.12 9.79 2289 358665 423006 109805339
Pancytopenia 244.20 9.79 1338 359616 208275 110020070
Multiple organ dysfunction syndrome 243.93 9.79 1062 359892 150648 110077697
Breast cancer stage III 241.96 9.79 3 360951 79114 110149231
Drug abuse 237.73 9.79 142 360812 177269 110051076
Oedema peripheral 236.74 9.79 1859 359095 326801 109901544
Dehydration 235.46 9.79 1641 359313 277870 109950475
Plasma cell myeloma 232.86 9.79 585 360369 62351 110165994
Ill-defined disorder 231.49 9.79 111 360843 156742 110071603
Completed suicide 229.09 9.79 272 360682 242109 109986236
Injury 229.06 9.79 148 360806 177117 110051228
Hyperuricaemia 226.48 9.79 258 360696 14273 110214072
Product monitoring error 226.09 9.79 206 360748 8721 110219624
Blood urea increased 224.83 9.79 531 360423 54426 110173919
Contraindicated product administered 224.77 9.79 288 360666 247979 109980366
Musculoskeletal stiffness 224.23 9.79 354 360600 279468 109948877
Bradycardia 219.75 9.79 1048 359906 154469 110073876
Neutropenia 219.19 9.79 2023 358931 372597 109855748
Haemoglobin decreased 218.20 9.79 1475 359479 247252 109981093
Dermatitis exfoliative generalised 211.61 9.79 218 360736 10754 110217591
Hypersensitivity 211.58 9.79 647 360307 403351 109824994
Joint range of motion decreased 204.47 9.79 71 360883 121761 110106584
Product use issue 203.19 9.79 447 360507 311248 109917097
Product prescribing error 196.08 9.79 483 360471 50848 110177497
Platelet count decreased 193.47 9.79 1352 359602 229091 109999254
Grip strength decreased 192.93 9.79 19 360935 80155 110148190
Appendicolith 192.17 9.79 235 360719 14020 110214325
Live birth 192.10 9.79 8 360946 69476 110158869
Labelled drug-drug interaction medication error 190.79 9.79 343 360611 28959 110199386
Gastrointestinal disorder 190.15 9.79 310 360644 241642 109986703
Toxicity to various agents 187.00 9.79 869 360085 479686 109748659
Hypoglycaemia 186.79 9.79 813 360141 115291 110113054
Osteoarthritis 185.65 9.79 193 360761 182430 110045915
Therapeutic product effect incomplete 184.19 9.79 278 360676 223527 110004818
International normalised ratio increased 182.64 9.79 661 360293 86111 110142234
Chronic lymphocytic leukaemia 179.79 9.79 152 360802 5816 110222529
Gastrointestinal haemorrhage 179.79 9.79 1037 359917 164481 110063864
Haematoma 176.40 9.79 504 360450 57972 110170373
Bursitis 175.43 9.79 103 360851 129815 110098530
Intentional overdose 172.02 9.79 110 360844 132391 110095954
Rhabdomyolysis 170.53 9.79 812 360142 119589 110108756
Migraine 170.47 9.79 185 360769 171467 110056878
Blood lactate dehydrogenase increased 168.10 9.79 416 360538 43918 110184427
Hypoaesthesia 165.33 9.79 502 360452 313721 109914624
Type 2 diabetes mellitus 165.19 9.79 201 360753 177031 110051314
Weight increased 164.92 9.79 756 360198 418888 109809457
Wound infection 163.99 9.79 55 360899 96410 110131935
Swelling 162.62 9.79 593 360361 350448 109877897
Hyperphosphataemia 159.09 9.79 230 360724 16151 110212194
Lactic acidosis 158.64 9.79 662 360292 92149 110136196
Autoimmune disorder 156.31 9.79 16 360938 65467 110162878
Purpura 151.83 9.79 280 360674 24108 110204237
Blister 151.52 9.79 322 360632 227054 110001291
Dermatitis exfoliative 151.25 9.79 186 360768 11161 110217184
Product use in unapproved indication 150.25 9.79 851 360103 446526 109781819
Pleural effusion 147.58 9.79 1040 359914 176669 110051676
Epistaxis 145.62 9.79 823 360131 129549 110098796
Injection site pain 144.47 9.79 223 360731 177699 110050646
Blood phosphorus increased 142.30 9.79 218 360736 16122 110212223
Urticaria 141.58 9.79 548 360406 318309 109910036
Insomnia 139.05 9.79 654 360300 359936 109868409
Pregnancy 137.52 9.79 7 360947 51060 110177285
Metabolic acidosis 135.69 9.79 665 360289 99079 110129266
Face oedema 135.39 9.79 322 360632 33147 110195198
Peripheral venous disease 134.44 9.79 53 360901 84064 110144281
Road traffic accident 134.23 9.79 93 360861 107305 110121040
Haematuria 133.31 9.79 581 360373 82424 110145921
Injection site reaction 132.99 9.79 62 360892 89008 110139337
Depression 129.86 9.79 563 360391 316772 109911573
Anxiety 129.47 9.79 632 360322 344446 109883899
Dislocation of vertebra 128.14 9.79 3 360951 43718 110184627
Night sweats 126.92 9.79 150 360804 133833 110094512
Nail disorder 126.48 9.79 19 360935 57916 110170429
Paraesthesia 126.13 9.79 470 360484 276051 109952294
Acute myeloid leukaemia 125.33 9.79 339 360615 37771 110190574
Appendicitis 122.96 9.79 281 360673 28183 110200162
Splenomegaly 121.90 9.79 256 360698 24242 110204103
Blepharospasm 119.72 9.79 18 360936 54833 110173512
Neutropenic sepsis 118.15 9.79 290 360664 30456 110197889
Hip arthroplasty 118.02 9.79 20 360934 55793 110172552
Lower limb fracture 117.94 9.79 49 360905 75299 110153046
Coeliac disease 116.04 9.79 6 360948 43181 110185164
Injection site erythema 115.78 9.79 83 360871 94093 110134252
Sleep disorder 114.27 9.79 304 360650 198340 110030005
Sciatica 114.17 9.79 81 360873 92318 110136027
Stomatitis 113.91 9.79 474 360480 269768 109958577
Blood cholesterol increased 113.88 9.79 273 360681 184512 110043833
Cardiac failure congestive 113.50 9.79 863 360091 150137 110078208
Cardiogenic shock 112.46 9.79 427 360527 56911 110171434
Onychomadesis 112.05 9.79 10 360944 45653 110182692
Gait inability 109.68 9.79 172 360782 136204 110092141
Mobility decreased 108.62 9.79 403 360551 237019 109991326
Pneumonia 108.20 9.79 3680 357274 873034 109355311
Asthma 107.99 9.79 435 360519 249856 109978489
Product quality issue 107.62 9.79 59 360895 77240 110151105
Obesity 107.26 9.79 127 360827 113224 110115121
Red blood cell sedimentation rate increased 105.81 9.79 62 360892 78240 110150105
Wheezing 105.51 9.79 451 360503 254779 109973566
Hypercholesterolaemia 105.35 9.79 85 360869 90752 110137593
Inflammation 104.99 9.79 304 360650 192934 110035411
Blood uric acid increased 104.83 9.79 223 360731 21306 110207039
Frequent bowel movements 104.58 9.79 51 360903 71339 110157006
Dyspnoea 104.55 9.79 4511 356443 1102361 109125984
X-ray abnormal 103.36 9.79 5 360949 38112 110190233
Loss of personal independence in daily activities 102.83 9.79 209 360745 149811 110078534
Product dose omission issue 102.16 9.79 623 360331 321159 109907186
Ascites 101.73 9.79 583 360371 92225 110136120
Tumour flare 100.32 9.79 63 360891 1504 110226841
Ventricular fibrillation 100.24 9.79 330 360624 40983 110187362
Activated partial thromboplastin time prolonged 100.16 9.79 224 360730 22144 110206201
Inappropriate schedule of product administration 98.92 9.79 337 360617 203300 110025045
Lupus vulgaris 96.79 9.79 3 360951 33880 110194465
Suicide attempt 96.60 9.79 117 360837 103277 110125068
Adverse event 96.59 9.79 128 360826 108681 110119664
Liver injury 95.25 9.79 219 360735 150194 110078151
Prescribed overdose 94.23 9.79 88 360866 87493 110140852
Erythema multiforme 94.17 9.79 211 360743 20886 110207459
Septic shock 93.64 9.79 854 360100 156674 110071671
Retinitis 91.85 9.79 3 360951 32324 110196021
Back injury 91.79 9.79 21 360933 47378 110180967
Peripheral swelling 91.38 9.79 860 360094 403174 109825171
Suicidal ideation 90.22 9.79 104 360850 93833 110134512
Lower respiratory tract infection 88.98 9.79 449 360505 242657 109985688
Memory impairment 88.96 9.79 336 360618 196608 110031737
Abortion spontaneous 88.35 9.79 6 360948 34276 110194069
Blood potassium increased 87.41 9.79 273 360681 32976 110195369
Electrolyte imbalance 87.37 9.79 293 360661 36735 110191610
Right atrial hypertrophy 86.02 9.79 43 360911 648 110227697
Benign prostatic hyperplasia 85.49 9.79 186 360768 18048 110210297
Cardiac failure chronic 85.26 9.79 158 360796 13653 110214692
Bacterial infection 84.71 9.79 336 360618 45700 110182645
Device expulsion 83.93 9.79 4 360950 30887 110197458
Onychomycosis 83.28 9.79 13 360941 38518 110189827
Asthenia 82.84 9.79 2884 358070 686115 109542230
Immune effector cell-associated neurotoxicity syndrome 82.49 9.79 162 360792 14620 110213725
Abdominal pain upper 82.00 9.79 736 360218 348375 109879970
Knee arthroplasty 81.47 9.79 56 360898 64892 110163453
Analgesic therapy 80.76 9.79 109 360845 7175 110221170
Ear infection 80.15 9.79 53 360901 62679 110165666
Epilepsy 79.99 9.79 127 360827 100082 110128263
Injection site swelling 79.23 9.79 52 360902 61738 110166607
Lupus-like syndrome 79.14 9.79 18 360936 40774 110187571
Exostosis 78.45 9.79 26 360928 45930 110182415
Leukopenia 78.22 9.79 786 360168 148005 110080340
Diabetes mellitus inadequate control 77.83 9.79 244 360710 29531 110198814
Sopor 77.39 9.79 279 360675 36267 110192078
Colitis ulcerative 77.20 9.79 83 360871 77280 110151065
Foot deformity 76.72 9.79 31 360923 48449 110179896
Dialysis 76.39 9.79 186 360768 19433 110208912
Breast cancer stage II 76.18 9.79 3 360951 27372 110200973
Injection site pruritus 76.02 9.79 36 360918 51222 110177123
Lymphoid tissue hypoplasia 75.43 9.79 54 360900 1611 110226734
Tubulointerstitial nephritis 75.31 9.79 364 360590 53920 110174425
Infective exacerbation of chronic obstructive airways disease 73.81 9.79 70 360884 3120 110225225
Glomerular filtration rate decreased 73.59 9.79 235 360719 28721 110199624
Condition aggravated 73.33 9.79 1832 359122 733004 109495341
Dyspnoea exertional 72.80 9.79 585 360369 103475 110124870
Therapy non-responder 72.59 9.79 266 360688 157041 110071304
Thymus hypoplasia 72.52 9.79 53 360901 1634 110226711
Inferior vena cava dilatation 72.47 9.79 43 360911 924 110227421
Musculoskeletal pain 72.23 9.79 329 360625 182694 110045651
Sleep disorder due to a general medical condition 72.22 9.79 40 360914 52072 110176273
Finger deformity 71.90 9.79 11 360943 33081 110195264
Drug therapy 71.72 9.79 103 360851 7188 110221157
Hypokalaemia 71.52 9.79 910 360044 181538 110046807
Haemodialysis 71.15 9.79 170 360784 17549 110210796
Subdural haematoma 71.09 9.79 271 360683 36183 110192162
Therapeutic drug monitoring analysis incorrectly performed 70.51 9.79 38 360916 674 110227671
Hypophosphataemia 69.99 9.79 253 360701 32929 110195416
Ventricular enlargement 69.92 9.79 38 360916 686 110227659
Hypervolaemia 69.58 9.79 333 360621 49127 110179218
Neck pain 68.86 9.79 191 360763 122939 110105406
Gouty arthritis 68.80 9.79 51 360903 1608 110226737
Anuria 68.79 9.79 205 360749 24136 110204209
Blood pressure fluctuation 68.49 9.79 86 360868 74738 110153607
Exercise tolerance decreased 68.25 9.79 133 360821 11934 110216411
End stage renal disease 66.62 9.79 187 360767 21286 110207059
Agranulocytosis 66.39 9.79 386 360568 61374 110166971
Cardioactive drug level increased 65.77 9.79 72 360882 3810 110224535
Pulmonary fibrosis 65.06 9.79 148 360806 101894 110126451
Diabetes mellitus 64.33 9.79 549 360405 98832 110129513
Diarrhoea 64.31 9.79 4428 356526 1135077 109093268
Laryngitis 64.11 9.79 29 360925 42382 110185963
Drug resistance 63.82 9.79 54 360900 56320 110172025
Differentiation syndrome 63.30 9.79 63 360891 2981 110225364
Dyspepsia 63.07 9.79 365 360589 190600 110037745
Overdose 63.02 9.79 475 360479 233319 109995026
Multiple drug therapy 62.97 9.79 102 360852 7912 110220433
Bone erosion 62.25 9.79 37 360917 46334 110182011
Rash morbilliform 62.21 9.79 101 360853 7850 110220495
Constipation 62.09 9.79 1568 359386 356218 109872127
Injection site bruising 61.94 9.79 46 360908 51217 110177128
Pemphigoid 61.52 9.79 172 360782 19535 110208810
Underdose 61.42 9.79 70 360884 63484 110164861
Fatigue 61.37 9.79 3295 357659 1212663 109015682
Disseminated aspergillosis 60.41 9.79 56 360898 2424 110225921
Accidental exposure to product 60.26 9.79 45 360909 49963 110178382
Sleep disorder therapy 59.95 9.79 96 360858 7375 110220970
Adverse drug reaction 58.84 9.79 164 360790 105395 110122950
Muscle spasms 58.68 9.79 602 360352 277555 109950790
Gravitational oedema 58.53 9.79 49 360905 1849 110226496
Epididymitis 58.41 9.79 55 360899 2429 110225916
Taste disorder 57.95 9.79 77 360877 65310 110163035
Prescribed underdose 57.50 9.79 77 360877 65097 110163248
Myasthenia gravis 56.89 9.79 177 360777 21334 110207011
Arrhythmia 56.45 9.79 405 360549 69170 110159175
Respiratory failure 55.95 9.79 1001 359953 214331 110014014
Pain in extremity 55.65 9.79 1189 359765 485929 109742416
Adverse reaction 55.56 9.79 14 360940 29580 110198765
Bone marrow failure 55.48 9.79 351 360603 57497 110170848
COVID-19 pneumonia 55.12 9.79 254 360700 36889 110191456
Antacid therapy 54.72 9.79 78 360876 5406 110222939
Hypocalcaemia 54.48 9.79 383 360571 64983 110163362
Arthritis 54.44 9.79 322 360632 167264 110061081
Ear pain 54.35 9.79 56 360898 53170 110175175
Aortic stenosis 53.20 9.79 126 360828 12933 110215412
Haematochezia 53.08 9.79 594 360360 114930 110113415
Breast cancer 52.81 9.79 30 360924 38512 110189833
Gamma-glutamyltransferase increased 52.73 9.79 362 360592 60947 110167398
White blood cell count decreased 52.59 9.79 1046 359908 228344 110000001
Acute generalised exanthematous pustulosis 52.51 9.79 173 360781 21491 110206854
Multiple sclerosis relapse 52.28 9.79 52 360902 50188 110178157
Right ventricular hypertrophy 52.23 9.79 44 360910 1675 110226670
Azotaemia 52.06 9.79 107 360847 9978 110218367
Joint stiffness 52.00 9.79 87 360867 67156 110161189
Hyperbilirubinaemia 51.79 9.79 218 360736 30453 110197892
Illness 51.72 9.79 120 360834 82051 110146294
Systemic infection 51.66 9.79 105 360849 9714 110218631
Anticoagulant therapy 51.66 9.79 75 360879 5286 110223059
IgM nephropathy 50.88 9.79 19 360935 132 110228213
Anaemia macrocytic 50.78 9.79 88 360866 7215 110221130
Escherichia sepsis 50.71 9.79 107 360847 10165 110218180
Iron deficiency 50.70 9.79 154 360800 18322 110210023
Multimorbidity 50.55 9.79 41 360913 1479 110226866
Atrial flutter 50.33 9.79 184 360770 24078 110204267
Intentional self-injury 50.05 9.79 30 360924 37399 110190946
Skin exfoliation 49.96 9.79 471 360483 87180 110141165
Therapeutic drug monitoring analysis not performed 49.76 9.79 45 360909 1886 110226459
Angioedema 49.68 9.79 516 360438 97984 110130361
Upper gastrointestinal haemorrhage 49.31 9.79 306 360648 49790 110178555
Degenerative mitral valve disease 48.82 9.79 23 360931 302 110228043
Urinary retention 48.33 9.79 391 360563 69292 110159053
Pulmonary function test abnormal 48.25 9.79 70 360884 4930 110223415
Anti-neutrophil cytoplasmic antibody positive vasculitis 48.20 9.79 73 360881 5344 110223001
Cholestasis 47.48 9.79 367 360587 64151 110164194
Therapeutic response decreased 47.31 9.79 159 360795 96340 110132005
Hypercreatininaemia 47.15 9.79 37 360917 1272 110227073
Glomerular filtration rate abnormal 47.14 9.79 48 360906 2335 110226010
Presyncope 47.11 9.79 297 360657 48590 110179755
Lymphadenopathy 46.91 9.79 363 360591 63472 110164873
Vaginal discharge 46.55 9.79 3 360951 17905 110210440
Hepatic cirrhosis 46.51 9.79 94 360860 67532 110160813
Aortic valve stenosis 46.11 9.79 78 360876 6272 110222073
Soft tissue mass 46.09 9.79 39 360915 1494 110226851
Aspartate aminotransferase increased 45.70 9.79 755 360199 159181 110069164
Myelofibrosis 45.57 9.79 53 360901 2998 110225347
Prostate cancer recurrent 45.43 9.79 32 360922 930 110227415
Drug ineffective for unapproved indication 45.42 9.79 177 360777 102661 110125684
Infection 45.25 9.79 871 360083 361329 109867016
Disability 45.17 9.79 21 360933 30202 110198143
Hepatic failure 45.15 9.79 381 360573 68358 110159987
Blood creatine phosphokinase increased 44.85 9.79 399 360555 72678 110155667
No adverse event 44.75 9.79 110 360844 73729 110154616
Acute myocardial infarction 44.71 9.79 444 360510 83333 110145012
Diastolic dysfunction 44.51 9.79 114 360840 12290 110216055
Dilatation intrahepatic duct acquired 44.42 9.79 30 360924 813 110227532
Conjunctivitis 44.31 9.79 223 360731 33569 110194776
Leukocytosis 44.05 9.79 314 360640 53514 110174831
Febrile infection 43.99 9.79 63 360891 4385 110223960
Dysuria 43.43 9.79 341 360613 59890 110168455
Myelosuppression 43.20 9.79 160 360794 94180 110134165
Cerebral haemorrhage 43.15 9.79 361 360593 64607 110163738
Cardiomegaly 43.08 9.79 199 360755 28931 110199414
Serotonin syndrome 42.61 9.79 80 360874 59073 110169272
HLA-B*5801 assay positive 42.55 9.79 9 360945 0 110228345
Shock haemorrhagic 42.43 9.79 189 360765 27058 110201287
Hypersensitivity vasculitis 42.37 9.79 79 360875 6858 110221487
Pulmonary hypertension 42.25 9.79 317 360637 54903 110173442
Rhinorrhoea 42.03 9.79 182 360772 102484 110125861
Pulmonary oedema 41.98 9.79 508 360446 100151 110128194
Petechiae 41.94 9.79 169 360785 23148 110205197
Blood pressure inadequately controlled 41.80 9.79 83 360871 7550 110220795
Electrocardiogram abnormal 41.47 9.79 145 360809 18564 110209781
Blood creatine increased 41.46 9.79 106 360848 11415 110216930
Therapy partial responder 41.34 9.79 36 360918 37025 110191320
Coronary artery disease 41.24 9.79 386 360568 71304 110157041
SJS-TEN overlap 41.23 9.79 40 360914 1834 110226511
Rales 41.12 9.79 175 360779 24564 110203781
Blood alkaline phosphatase increased 40.84 9.79 382 360572 70553 110157792
Dry mouth 40.82 9.79 436 360518 199512 110028833
Charles Bonnet syndrome 40.71 9.79 13 360941 52 110228293
Infusion site reaction 40.49 9.79 5 360949 17677 110210668
Chronic obstructive pulmonary disease 40.47 9.79 539 360415 108619 110119726
Lung consolidation 40.45 9.79 99 360855 10377 110217968
Sedation complication 40.07 9.79 8 360946 19847 110208498
Gouty tophus 39.87 9.79 23 360931 468 110227877
Death 39.85 9.79 2719 358235 696150 109532195
Cardiac failure acute 39.77 9.79 170 360784 23908 110204437
Drug tolerance 39.72 9.79 4 360950 16581 110211764
Hypovolaemic shock 39.50 9.79 121 360833 14462 110213883
Troponin increased 39.43 9.79 197 360757 29569 110198776
Disorientation 39.40 9.79 378 360576 70293 110158052
Hyperglycaemia 39.31 9.79 438 360516 84652 110143693
Drug use disorder 39.28 9.79 6 360948 18068 110210277
Urosepsis 39.22 9.79 201 360753 30474 110197871
Interstitial lung disease 39.16 9.79 656 360298 138678 110089667
Human herpesvirus 6 infection 39.02 9.79 74 360880 6507 110221838
Amnesia 38.93 9.79 194 360760 105214 110123131
Akathisia 38.79 9.79 5 360949 17108 110211237
Normocytic anaemia 38.69 9.79 73 360881 6394 110221951
Lymphocytosis 38.67 9.79 66 360888 5345 110223000
Cutaneous vasculitis 38.66 9.79 110 360844 12619 110215726
Atrial enlargement 38.18 9.79 31 360923 1120 110227225
Dermatitis bullous 38.12 9.79 135 360819 17394 110210951
Acute motor-sensory axonal neuropathy 37.92 9.79 23 360931 515 110227830
Drug withdrawal syndrome 37.77 9.79 41 360913 38013 110190332
Staphylococcal sepsis 37.59 9.79 134 360820 17320 110211025
Blast crisis in myelogenous leukaemia 37.41 9.79 29 360925 979 110227366
Poisoning deliberate 36.79 9.79 20 360934 26311 110202034
Lung disorder 36.59 9.79 393 360561 179654 110048691
Hyperlipidaemia 36.56 9.79 221 360733 35627 110192718
Nasal congestion 36.23 9.79 181 360773 98101 110130244
Clostridium difficile colitis 36.18 9.79 256 360698 43522 110184823
Joint dislocation 36.02 9.79 35 360919 34155 110194190
Lip erosion 35.85 9.79 37 360917 1829 110226516
Alanine aminotransferase increased 35.66 9.79 818 360136 182955 110045390
Needle fatigue 35.65 9.79 31 360923 1233 110227112
Disseminated intravascular coagulation 35.64 9.79 244 360710 41042 110187303
Renal disorder 35.60 9.79 280 360674 49199 110179146
Psoriasis 35.58 9.79 289 360665 139704 110088641
Ecchymosis 35.56 9.79 131 360823 17207 110211138
Prothrombin time prolonged 35.05 9.79 130 360824 17131 110211214
Device interaction 35.04 9.79 25 360929 742 110227603
Bradyarrhythmia 35.02 9.79 60 360894 4874 110223471
Mitral valve incompetence 34.97 9.79 207 360747 33122 110195223
Lipase increased 34.93 9.79 137 360817 18535 110209810
Rheumatoid factor negative 34.89 9.79 31 360923 1269 110227076
Serum ferritin increased 34.65 9.79 101 360853 11746 110216599
Hepatocellular injury 34.49 9.79 283 360671 50359 110177986
Enanthema 34.40 9.79 29 360925 1105 110227240
Aplasia pure red cell 34.34 9.79 88 360866 9490 110218855
Blood calcium increased 34.26 9.79 133 360821 17907 110210438
Infective pulmonary exacerbation of cystic fibrosis 34.26 9.79 4 360950 14767 110213578
Cellulitis 34.21 9.79 590 360364 125426 110102919
Hypomagnesaemia 34.20 9.79 324 360630 60046 110168299
Hypercalcaemia 34.11 9.79 265 360689 46392 110181953
Maternal exposure timing unspecified 33.97 9.79 13 360941 21000 110207345
Hypoxia 33.95 9.79 603 360351 128912 110099433
Walking aid user 33.67 9.79 20 360934 25055 110203290
Cytopenia 33.53 9.79 190 360764 29926 110198419
Myocardial ischaemia 33.52 9.79 174 360780 26510 110201835
Orthostatic hypotension 33.38 9.79 347 360607 65902 110162443
Mantle cell lymphoma 33.32 9.79 34 360920 1658 110226687
Blood bilirubin increased 33.26 9.79 387 360567 75585 110152760
Peripheral arterial occlusive disease 33.00 9.79 85 360869 9195 110219150
Body mass index abnormal 32.93 9.79 26 360928 902 110227443
Haemoptysis 32.82 9.79 367 360587 70987 110157358
Device dislocation 32.77 9.79 33 360921 31671 110196674
Lichenoid keratosis 32.69 9.79 67 360887 6235 110222110
Blood lactic acid 32.58 9.79 20 360934 458 110227887
Thrombosis 32.54 9.79 517 360437 108145 110120200
Haemophagocytic lymphohistiocytosis 32.47 9.79 195 360759 31364 110196981
Influenza 32.43 9.79 374 360580 168727 110059618
Chronic sinusitis 32.30 9.79 21 360933 25063 110203282
Respiratory depression 32.30 9.79 34 360920 31967 110196378
Red blood cell count decreased 32.14 9.79 343 360611 65580 110162765
Gastritis erosive 31.97 9.79 99 360855 11901 110216444
Transaminases increased 31.93 9.79 332 360622 63058 110165287
Blood parathyroid hormone decreased 31.76 9.79 3 360951 13086 110215259
Right ventricular failure 31.75 9.79 168 360786 25786 110202559
Mucosal ulceration 31.71 9.79 39 360915 2340 110226005
Pulmonary vascular disorder 31.69 9.79 27 360927 1044 110227301
Poisoning 31.59 9.79 29 360925 29076 110199269
Gastrooesophageal reflux disease 31.50 9.79 406 360548 179570 110048775
Acute respiratory failure 31.46 9.79 380 360574 74880 110153465
Duodenitis 31.44 9.79 83 360871 9113 110219232
Pericardial effusion 31.38 9.79 305 360649 56912 110171433
Impaired quality of life 31.31 9.79 31 360923 29986 110198359
Injection site haemorrhage 31.24 9.79 37 360917 32991 110195354
Organic brain syndrome 31.20 9.79 21 360933 566 110227779
Food allergy 31.17 9.79 13 360941 19935 110208410
Sinus congestion 31.15 9.79 32 360922 30427 110197918
Erysipelas 30.93 9.79 104 360850 13054 110215291
Neovascularisation 30.80 9.79 33 360921 1704 110226641
Sedation 30.73 9.79 120 360834 69563 110158782
Drug eruption 30.40 9.79 288 360666 53371 110174974
Procedural pain 30.39 9.79 43 360911 35522 110192823
Blood pressure increased 30.24 9.79 628 360326 257745 109970600
Malaise 30.21 9.79 1840 359114 669979 109558366
Blood urea abnormal 30.14 9.79 34 360920 1860 110226485
Hepatic vein dilatation 29.83 9.79 15 360939 229 110228116
Haemorrhage intracranial 29.81 9.79 179 360775 28790 110199555
Respiratory tract congestion 29.80 9.79 34 360920 30823 110197522
Device difficult to use 29.80 9.79 12 360942 18793 110209552
Vasculitis necrotising 29.71 9.79 31 360923 1552 110226793
Neutrophil count decreased 29.57 9.79 557 360397 120384 110107961
Lip oedema 29.53 9.79 72 360882 7528 110220817
Affect lability 29.36 9.79 12 360942 18625 110209720
Feeling abnormal 29.33 9.79 414 360540 180297 110048048
Device issue 29.26 9.79 42 360912 34493 110193852
Ventricular tachycardia 29.13 9.79 270 360684 49739 110178606
Device breakage 28.96 9.79 5 360949 13764 110214581
Injection site urticaria 28.93 9.79 10 360944 17205 110211140
Cardiovascular insufficiency 28.82 9.79 44 360910 3244 110225101
Female genital tract fistula 28.81 9.79 9 360945 16510 110211835
Diverticulum intestinal haemorrhagic 28.79 9.79 54 360900 4709 110223636
Oliguria 28.74 9.79 129 360825 18528 110209817
Tachyarrhythmia 28.69 9.79 75 360879 8186 110220159
Influenza like illness 28.64 9.79 170 360784 88242 110140103
Exposure to toxic agent 28.57 9.79 4 360950 12854 110215491
Hypertrophy 28.55 9.79 24 360930 911 110227434
Obstruction 28.49 9.79 60 360894 5692 110222653
Gait spastic 28.48 9.79 30 360924 1519 110226826
Seizure 28.18 9.79 530 360424 220655 110007690
Mood swings 28.17 9.79 20 360934 22792 110205553
Chills 28.11 9.79 818 360136 189762 110038583
Atrioventricular block complete 28.09 9.79 135 360819 19947 110208398
Rash pustular 28.07 9.79 99 360855 12730 110215615
Blood uric acid decreased 27.60 9.79 29 360925 1464 110226881
Burning sensation 27.54 9.79 124 360830 69088 110159257
Renal atrophy 27.38 9.79 36 360918 2310 110226035
Neuroleptic malignant syndrome 27.33 9.79 43 360911 34016 110194329
Hypocoagulable state 27.29 9.79 38 360916 2577 110225768
Sternal fracture 27.14 9.79 43 360911 3273 110225072
Blood sodium decreased 27.11 9.79 216 360738 38103 110190242
Autoimmune haemolytic anaemia 27.07 9.79 86 360868 10481 110217864
Psychotic disorder 27.02 9.79 81 360873 50856 110177489
Fibrin D dimer increased 26.96 9.79 82 360872 9763 110218582
Vascular purpura 26.96 9.79 46 360908 3725 110224620
Oligoasthenozoospermia 26.92 9.79 7 360947 10 110228335
Bronchial wall thickening 26.82 9.79 42 360912 3165 110225180
Macular degeneration 26.73 9.79 19 360935 21640 110206705
Orthopnoea 26.70 9.79 88 360866 10933 110217412
Dementia 26.64 9.79 186 360768 31487 110196858
Neuroglycopenia 26.61 9.79 25 360929 1101 110227244
Strangury 26.56 9.79 14 360940 237 110228108
Chronic myeloid leukaemia 26.52 9.79 49 360905 4224 110224121
Acute coronary syndrome 26.51 9.79 147 360807 22965 110205380
Jaundice 26.49 9.79 303 360651 58933 110169412
Mucosal erosion 26.48 9.79 39 360915 2785 110225560
Muscle spasticity 26.37 9.79 48 360906 35867 110192478
Multiple sclerosis 26.28 9.79 27 360927 25671 110202674
Electrolyte depletion 26.20 9.79 18 360936 502 110227843
Peripheral circulatory failure 26.17 9.79 31 360923 1788 110226557
Erectile dysfunction 26.15 9.79 125 360829 18431 110209914
Fall 26.10 9.79 2298 358656 601184 109627161
Therapeutic response shortened 26.04 9.79 35 360919 29548 110198797
Intestinal haemorrhage 25.86 9.79 67 360887 7274 110221071
Immunodeficiency 25.85 9.79 55 360899 38783 110189562
Injection site rash 25.82 9.79 23 360931 23396 110204949
Blood loss anaemia 25.82 9.79 122 360832 17903 110210442
Coronary artery stenosis 25.78 9.79 101 360853 13657 110214688
Paraesthesia oral 25.63 9.79 44 360910 33627 110194718
Cardiac aneurysm 25.54 9.79 30 360924 1715 110226630
Feeling hot 25.54 9.79 183 360771 90923 110137422
Monoparesis 25.53 9.79 50 360904 4503 110223842
Erosive oesophagitis 25.40 9.79 40 360914 3029 110225316
Mydriasis 25.35 9.79 21 360933 22136 110206209
Acne 25.33 9.79 44 360910 33476 110194869
Base excess decreased 25.26 9.79 16 360938 388 110227957
Substance abuse 25.20 9.79 5 360949 12458 110215887
Soft tissue injury 25.14 9.79 34 360920 2242 110226103
Oesophageal perforation 25.08 9.79 29 360925 1630 110226715
Acute febrile neutrophilic dermatosis 25.04 9.79 52 360902 4884 110223461
Prerenal failure 25.04 9.79 49 360905 4410 110223935
Narrow anterior chamber angle 24.92 9.79 12 360942 166 110228179
Aplastic anaemia 24.88 9.79 150 360804 24158 110204187
Withdrawal syndrome 24.82 9.79 40 360914 31340 110197005
Colon cancer 24.81 9.79 113 360841 16330 110212015
Blood cholesterol decreased 24.73 9.79 37 360917 2679 110225666
Liver palpable 24.73 9.79 15 360939 336 110228009
Haematocrit decreased 24.72 9.79 327 360627 65790 110162555
Respiratory arrest 24.69 9.79 102 360852 58197 110170148
Oral mucosa erosion 24.69 9.79 35 360919 2413 110225932
Serositis 24.69 9.79 28 360926 1541 110226804
Hallucination, auditory 24.51 9.79 30 360924 26367 110201978
Gastroenteritis viral 24.51 9.79 40 360914 31186 110197159
Throat irritation 24.40 9.79 91 360863 53461 110174884
Periarthritis calcarea 24.36 9.79 10 360944 92 110228253
Heart rate increased 24.24 9.79 327 360627 143507 110084838
Tricuspid valve incompetence 24.24 9.79 147 360807 23726 110204619
Generalised tonic-clonic seizure 24.21 9.79 94 360860 54586 110173759
Temperature regulation disorder 24.21 9.79 6 360948 12820 110215525
Nephrogenic anaemia 24.15 9.79 49 360905 4528 110223817
Activated partial thromboplastin time shortened 24.09 9.79 23 360931 1034 110227311
Chemical burn of oral cavity 24.04 9.79 9 360945 63 110228282
Folate deficiency 23.99 9.79 48 360906 4390 110223955
Granuloma skin 23.95 9.79 4 360950 11279 110217066
Skin oedema 23.84 9.79 31 360923 1968 110226377
Sinus disorder 23.80 9.79 44 360910 32684 110195661
Nocturia 23.61 9.79 114 360840 16876 110211469
Escherichia bacteraemia 23.60 9.79 80 360874 10084 110218261
Acute pulmonary oedema 23.59 9.79 114 360840 16882 110211463
Heavy menstrual bleeding 23.50 9.79 12 360942 16353 110211992
Drug dose omission by device 23.43 9.79 9 360945 14507 110213838
Full blood count abnormal 23.42 9.79 283 360671 55769 110172576
Cerebral haematoma 23.42 9.79 77 360877 9555 110218790
Hepatitis acute 23.32 9.79 122 360832 18644 110209701
Gastric polyps 23.27 9.79 54 360900 5469 110222876
Pulmonary arterial hypertension 23.26 9.79 184 360770 32384 110195961
Microcytic anaemia 23.20 9.79 58 360896 6160 110222185
Myelodysplastic syndrome 23.17 9.79 205 360749 37279 110191066
Allergy to chemicals 23.03 9.79 40 360914 3285 110225060
Dermatitis artefacta 23.01 9.79 9 360945 72 110228273
Gait disturbance 22.93 9.79 712 360242 277496 109950849
Platelet distribution width increased 22.92 9.79 11 360943 151 110228194
Erythema 22.87 9.79 1167 359787 290280 109938065
Dermatitis allergic 22.84 9.79 135 360819 21589 110206756
Wrong technique in product usage process 22.80 9.79 179 360775 87169 110141176
Central nervous system lupus 22.76 9.79 25 360929 1328 110227017
Full blood count decreased 22.74 9.79 181 360773 31918 110196427
Foot fracture 22.72 9.79 30 360924 25516 110202829
Localised oedema 22.66 9.79 74 360880 9149 110219196
Malignant spinal cord compression 22.66 9.79 11 360943 155 110228190
Thermohypoaesthesia 22.63 9.79 10 360944 112 110228233
Radiculopathy 22.53 9.79 18 360936 19318 110209027
Drug effective for unapproved indication 22.51 9.79 9 360945 14158 110214187
Sneezing 22.38 9.79 44 360910 31940 110196405
Chronic lymphocytic leukaemia recurrent 22.35 9.79 22 360932 1027 110227318
Contusion 22.33 9.79 585 360369 232776 109995569
Abnormal loss of weight 22.31 9.79 79 360875 10178 110218167
Respiratory distress 22.27 9.79 332 360622 68542 110159803
Schizophrenia 22.24 9.79 23 360931 21803 110206542
Cardiac arrest 22.17 9.79 818 360136 195935 110032410
Rash maculovesicular 22.14 9.79 8 360946 50 110228295
Epidermolysis 21.99 9.79 23 360931 1155 110227190
Ejection fraction decreased 21.97 9.79 217 360737 40663 110187682
Pneumonia fungal 21.97 9.79 101 360853 14653 110213692
Neutropenic colitis 21.92 9.79 67 360887 7998 110220347
Crying 21.88 9.79 31 360923 25597 110202748
Skin ulcer 21.85 9.79 310 360644 63335 110165010
Systolic dysfunction 21.80 9.79 46 360908 4369 110223976
HLA marker study positive 21.72 9.79 12 360942 224 110228121
Multiple-drug resistance 21.71 9.79 8 360946 13227 110215118
Hepatitis cholestatic 21.69 9.79 114 360840 17452 110210893
Limb discomfort 21.65 9.79 65 360889 40789 110187556
Ankylosing spondylitis 21.61 9.79 12 360942 15600 110212745
Circulatory collapse 21.57 9.79 225 360729 42768 110185577
Premature delivery 21.56 9.79 42 360912 30590 110197755
Forced expiratory volume decreased 21.55 9.79 8 360946 13168 110215177
Breast cancer female 21.38 9.79 7 360947 12461 110215884
Relapsing-remitting multiple sclerosis 21.34 9.79 30 360924 2052 110226293
Mixed liver injury 21.29 9.79 87 360867 11992 110216353
Shock 21.28 9.79 268 360686 53320 110175025
Device leakage 21.27 9.79 13 360941 16035 110212310
Pancreatitis acute 21.26 9.79 295 360659 59979 110168366
Ischaemic cardiomyopathy 21.26 9.79 66 360888 7945 110220400
Subdural haemorrhage 21.22 9.79 58 360896 6500 110221845
Angina pectoris 21.21 9.79 303 360651 61992 110166353
Faeces discoloured 21.16 9.79 186 360768 33762 110194583
Sinoatrial block 21.14 9.79 25 360929 1440 110226905
Hormone-refractory prostate cancer 21.11 9.79 20 360934 890 110227455
Encephalopathy 21.10 9.79 377 360577 80678 110147667
Mental disorder 21.07 9.79 61 360893 38730 110189615
Anaphylactic reaction 21.06 9.79 255 360699 114045 110114300
Hypoglycaemic coma 21.06 9.79 52 360902 5481 110222864
Glomerular filtration rate 20.98 9.79 11 360943 184 110228161
Atrioventricular block first degree 20.90 9.79 97 360857 14128 110214217
Brain natriuretic peptide increased 20.77 9.79 82 360872 11127 110217218
Hostility 20.76 9.79 34 360920 2662 110225683
Haemolytic anaemia 20.72 9.79 128 360826 20792 110207553
Hepatic function abnormal 20.72 9.79 408 360546 88887 110139458
Adrenal insufficiency 20.67 9.79 70 360884 42320 110186025
Tachypnoea 20.63 9.79 208 360746 39187 110189158
Synovial disorder 20.60 9.79 36 360918 2971 110225374
Arrhythmia supraventricular 20.41 9.79 32 360922 2414 110225931
Diverticulum intestinal 20.33 9.79 84 360870 11635 110216710
Haematemesis 20.33 9.79 288 360666 58820 110169525
Stenosis 20.26 9.79 38 360916 3313 110225032
Post transplant lymphoproliferative disorder 20.20 9.79 13 360941 15600 110212745
Diffuse large B-cell lymphoma 20.20 9.79 104 360850 15794 110212551
Platelet disorder 20.17 9.79 40 360914 3635 110224710
Panniculitis 20.13 9.79 13 360941 15569 110212776
Blood pressure decreased 20.10 9.79 505 360449 114586 110113759
Bacteroides infection 20.07 9.79 35 360919 2884 110225461
Intentional product misuse 19.99 9.79 309 360645 132595 110095750
Bronchial secretion retention 19.95 9.79 48 360906 4976 110223369
Left ventricular enlargement 19.94 9.79 19 360935 852 110227493
Transfusion 19.92 9.79 147 360807 25325 110203020
Decreased gait velocity 19.88 9.79 11 360943 206 110228139
Chest X-ray abnormal 19.88 9.79 67 360887 8420 110219925
Potentiating drug interaction 19.85 9.79 83 360871 11560 110216785
Hypertensive crisis 19.84 9.79 142 360812 24230 110204115
Cardiac autonomic neuropathy 19.84 9.79 8 360946 70 110228275
Ischaemic stroke 19.79 9.79 214 360740 41049 110187296
Eosinophilic pustular folliculitis 19.75 9.79 10 360944 155 110228190
Pelvic mass 19.71 9.79 24 360930 1425 110226920
Respiratory disorder 19.71 9.79 144 360810 71238 110157107
Nicotine dependence 19.68 9.79 23 360931 1308 110227037
Vomiting 19.59 9.79 2639 358315 908036 109320309
Bipolar disorder 19.55 9.79 3 360951 9004 110219341
Muscle haemorrhage 19.55 9.79 58 360896 6811 110221534
Libido increased 19.52 9.79 32 360922 2507 110225838
Lower gastrointestinal haemorrhage 19.52 9.79 115 360839 18371 110209974
Rash pruritic 19.47 9.79 438 360516 97631 110130714
Middle insomnia 19.41 9.79 124 360830 20378 110207967
Visual impairment 19.40 9.79 315 360639 134113 110094232
Renal vasculitis 19.38 9.79 17 360937 684 110227661
Allergic reaction to excipient 19.38 9.79 18 360936 781 110227564
Duodenal ulcer haemorrhage 19.32 9.79 64 360890 7973 110220372
Dermatosis 19.22 9.79 20 360934 998 110227347
Hyperpyrexia 19.17 9.79 64 360890 8005 110220340
Genital erosion 19.15 9.79 18 360936 793 110227552
Liver function test abnormal 19.14 9.79 324 360630 68626 110159719
Post-traumatic neck syndrome 19.01 9.79 32 360922 2563 110225782
Hydronephrosis 18.96 9.79 124 360830 20541 110207804
Device malfunction 18.91 9.79 34 360920 25524 110202821
Injection site mass 18.88 9.79 32 360922 24581 110203764
Pleuritic pain 18.75 9.79 103 360851 16037 110212308
Mandibular mass 18.72 9.79 11 360943 232 110228113
Osteoporosis 18.61 9.79 188 360766 86964 110141381
Fixed eruption 18.52 9.79 42 360912 4190 110224155
Serum ferritin abnormal 18.52 9.79 14 360940 455 110227890
Neurotoxicity 18.47 9.79 215 360739 41992 110186353
Prostatomegaly 18.45 9.79 42 360912 4200 110224145
Flushing 18.42 9.79 236 360718 104500 110123845
Mucosal disorder 18.41 9.79 43 360911 4374 110223971
Oedema mouth 18.32 9.79 35 360919 3095 110225250
Chronic myeloid leukaemia transformation 18.24 9.79 12 360942 311 110228034
Post-traumatic amnestic disorder 18.23 9.79 7 360947 53 110228292
Cardiac amyloidosis 18.20 9.79 33 360921 2804 110225541
Papillary muscle rupture 18.18 9.79 5 360949 10 110228335
Blood electrolytes abnormal 18.18 9.79 28 360926 2080 110226265
Cardiovascular disorder 18.17 9.79 132 360822 22628 110205717
Gingival bleeding 18.17 9.79 119 360835 19720 110208625
Mantle cell lymphoma refractory 18.16 9.79 9 360945 133 110228212
Anticoagulation drug level above therapeutic 18.14 9.79 44 360910 4586 110223759
Human herpes virus 6 serology positive 18.11 9.79 11 360943 247 110228098
Inguinal hernia 18.11 9.79 61 360893 7664 110220681
Urine output decreased 18.07 9.79 119 360835 19757 110208588
Endocarditis 18.07 9.79 89 360865 13282 110215063
Thrombotic microangiopathy 18.00 9.79 43 360911 29106 110199239
Drug dependence 17.93 9.79 93 360861 49927 110178418
Trichiasis 17.92 9.79 9 360945 137 110228208
Adrenal cyst 17.92 9.79 11 360943 252 110228093
Dyspnoea at rest 17.91 9.79 64 360890 8282 110220063
Strangulated umbilical hernia 17.86 9.79 5 360949 11 110228334
Diabetic nephropathy 17.85 9.79 37 360917 3471 110224874
Renal function test abnormal 17.85 9.79 67 360887 8879 110219466
Subcutaneous haematoma 17.83 9.79 34 360920 3002 110225343
Immune reconstitution inflammatory syndrome 17.81 9.79 16 360938 16210 110212135
Red blood cell sedimentation rate abnormal 17.78 9.79 33 360921 24476 110203869
Aptyalism 17.77 9.79 18 360936 870 110227475
Vision blurred 17.74 9.79 305 360649 128717 110099628
Weight fluctuation 17.73 9.79 28 360926 22117 110206228
N-terminal prohormone brain natriuretic peptide increased 17.72 9.79 52 360902 6069 110222276
Autonomic neuropathy 17.70 9.79 29 360925 2271 110226074
Type V hyperlipidaemia 17.70 9.79 23 360931 1459 110226886
Vascular pseudoaneurysm 17.69 9.79 41 360913 4149 110224196
Enterococcus test positive 17.65 9.79 33 360921 2871 110225474
Cutaneous T-cell lymphoma stage I 17.64 9.79 9 360945 142 110228203
Pseudomonal sepsis 17.43 9.79 67 360887 8979 110219366
Extravasation blood 17.41 9.79 14 360940 499 110227846
Hypertensive heart disease 17.29 9.79 43 360911 4553 110223792
Tinnitus 17.26 9.79 121 360833 60419 110167926
Fear of injection 17.15 9.79 4 360950 8907 110219438
Disease progression 17.11 9.79 967 359987 243067 109985278
Rhinitis allergic 17.03 9.79 20 360934 17902 110210443
Gastritis 17.03 9.79 258 360696 53441 110174904
Seronegative arthritis 17.01 9.79 11 360943 13166 110215179
Injection site warmth 17.00 9.79 19 360935 17386 110210959
Urinary tract obstruction 16.97 9.79 46 360908 5131 110223214
Testicular swelling 16.96 9.79 24 360930 1652 110226693
Complication of device insertion 16.95 9.79 4 360950 8834 110219511
Scrotal oedema 16.91 9.79 24 360930 1657 110226688
Fistula 16.90 9.79 15 360939 15284 110213061
Sight disability 16.89 9.79 10 360944 214 110228131
Bacteraemia 16.84 9.79 212 360742 42178 110186167
Chronic lymphocytic leukaemia transformation 16.83 9.79 11 360943 282 110228063
Bundle branch block right 16.74 9.79 82 360872 12209 110216136
Abortion induced 16.68 9.79 3 360951 8016 110220329
Renal cyst 16.65 9.79 109 360845 18063 110210282
Subarachnoid haemorrhage 16.62 9.79 159 360795 29543 110198802
Sinus node dysfunction 16.61 9.79 66 360888 8981 110219364
Cytomegalovirus nephritis 16.58 9.79 9 360945 162 110228183
Coombs positive haemolytic anaemia 16.58 9.79 23 360931 1554 110226791
Sensitivity to weather change 16.55 9.79 6 360948 10022 110218323
Diverticulitis 16.53 9.79 256 360698 53266 110175079
Lacunar stroke 16.53 9.79 14 360940 537 110227808
Pulmonary haemorrhage 16.50 9.79 101 360853 16355 110211990
Staphylococcal bacteraemia 16.46 9.79 102 360852 16586 110211759
Blood chloride increased 16.45 9.79 52 360902 6320 110222025
Resting tremor 16.45 9.79 24 360930 1699 110226646
Sudden death 16.44 9.79 136 360818 24259 110204086
Pulmonary sepsis 16.41 9.79 46 360908 5232 110223113
Subacute hepatic failure 16.37 9.79 10 360944 227 110228118
Eosinopenia 16.34 9.79 8 360946 115 110228230
Respiratory tract haemorrhage 16.33 9.79 26 360928 1988 110226357
Hypertonic bladder 16.28 9.79 46 360908 5256 110223089
Hyperamylasaemia 16.25 9.79 20 360934 1201 110227144
Pulmonary embolism 16.25 9.79 856 360098 213618 110014727
Head discomfort 16.20 9.79 23 360931 18977 110209368
Fracture blisters 16.20 9.79 7 360947 74 110228271
Enterococcal infection 16.20 9.79 118 360836 20248 110208097
Blood glucose increased 16.19 9.79 556 360398 131940 110096405
Helicobacter test positive 16.16 9.79 21 360933 1332 110227013
Myeloblast percentage decreased 16.15 9.79 6 360948 41 110228304
Blood pressure ambulatory increased 16.12 9.79 7 360947 75 110228270
Actinic keratosis 16.11 9.79 55 360899 6958 110221387
Iridocele 16.07 9.79 5 360949 18 110228327
Dissociation 16.06 9.79 6 360948 9836 110218509
White blood cell count increased 16.06 9.79 422 360532 96420 110131925
Meibomian gland dysfunction 16.01 9.79 11 360943 307 110228038
Amylase increased 15.98 9.79 82 360872 12437 110215908
Parathyroid hyperplasia 15.97 9.79 9 360945 175 110228170
Uveitis 15.95 9.79 29 360925 21681 110206664
Drug tolerance decreased 15.93 9.79 42 360912 27498 110200847
Urinary hesitation 15.88 9.79 42 360912 4616 110223729
Oroantral fistula 15.79 9.79 12 360942 393 110227952
Acute lymphocytic leukaemia 15.77 9.79 48 360906 5717 110222628
Articular calcification 15.77 9.79 10 360944 243 110228102
Diabetic ketoacidosis 15.76 9.79 77 360877 41981 110186364
Anaphylactic shock 15.71 9.79 101 360853 51445 110176900
Right ventricular enlargement 15.69 9.79 18 360936 1003 110227342
Lens dislocation 15.65 9.79 9 360945 182 110228163
Back pain 15.62 9.79 1022 359932 369974 109858371
International normalised ratio abnormal 15.62 9.79 51 360903 6306 110222039
Copper deficiency 15.56 9.79 9 360945 184 110228161
Hypertension 15.56 9.79 1443 359511 508641 109719704
Blood chloride decreased 15.55 9.79 65 360889 9050 110219295
Nephrocalcinosis 15.51 9.79 24 360930 1790 110226555
Vaginal haemorrhage 15.47 9.79 37 360917 25037 110203308
Neuralgia 15.41 9.79 233 360721 48245 110180100
Emotional disorder 15.40 9.79 18 360936 16142 110212203
Alopecia scarring 15.39 9.79 9 360945 188 110228157
Procalcitonin increased 15.31 9.79 38 360916 4018 110224327
Cerebral infarction 15.28 9.79 246 360708 51592 110176753
Hypercapnic coma 15.27 9.79 13 360941 502 110227843
Lymphadenitis 15.27 9.79 46 360908 5447 110222898
Hyperhidrosis 15.26 9.79 480 360474 186818 110041527
Anal haemorrhage 15.24 9.79 43 360911 4909 110223436
Haemorrhage 15.20 9.79 456 360498 106236 110122109
Congenital hiatus hernia 15.18 9.79 50 360904 6209 110222136
Bone marrow reticulin fibrosis 15.17 9.79 11 360943 335 110228010
Rash macular 15.16 9.79 193 360761 38493 110189852
Musculoskeletal disorder 15.16 9.79 32 360922 22632 110205713
Renal transplant 15.14 9.79 33 360921 3205 110225140
Metastases to lymph nodes 15.14 9.79 16 360938 15016 110213329
General symptom 15.11 9.79 5 360949 8841 110219504
Leukocyturia 15.07 9.79 27 360927 2273 110226072
Thrombin time prolonged 15.06 9.79 11 360943 339 110228006
Squamous cell carcinoma of skin 15.04 9.79 102 360852 17101 110211244
Amaurosis 14.98 9.79 22 360932 1567 110226778
Blood pressure systolic increased 14.97 9.79 186 360768 82805 110145540
Abdominal wall wound 14.92 9.79 7 360947 91 110228254
Vessel puncture site haemorrhage 14.90 9.79 9 360945 200 110228145
Breast cancer metastatic 14.90 9.79 9 360945 11172 110217173
Needle issue 14.82 9.79 22 360932 17818 110210527
Tongue dry 14.78 9.79 20 360934 1320 110227025
Blood uric acid abnormal 14.77 9.79 12 360942 434 110227911
Sarcopenia 14.75 9.79 19 360935 1195 110227150
Caesarean section 14.72 9.79 14 360940 13803 110214542
Congestive cardiomyopathy 14.72 9.79 88 360866 14131 110214214
Atrioventricular block 14.72 9.79 100 360854 16777 110211568
Hormone-dependent prostate cancer 14.70 9.79 9 360945 205 110228140
Hepatic calcification 14.64 9.79 11 360943 354 110227991
Prostatic specific antigen increased 14.64 9.79 80 360874 12431 110215914
Periorbital oedema 14.61 9.79 69 360885 10123 110218222
Sudden cardiac death 14.55 9.79 46 360908 5591 110222754
Capillary leak syndrome 14.50 9.79 42 360912 4866 110223479
Pathogen resistance 14.48 9.79 22 360932 17650 110210695
Preternatural anus 14.46 9.79 7 360947 98 110228247
Gastritis haemorrhagic 14.46 9.79 32 360922 3141 110225204
Amenorrhoea 14.45 9.79 6 360948 9225 110219120
Haemolysis 14.44 9.79 94 360860 15545 110212800
Blood blister 14.40 9.79 36 360918 3823 110224522
Exposure via skin contact 14.39 9.79 13 360941 13134 110215211
Lung infiltration 14.36 9.79 133 360821 24495 110203850
Gastric disorder 14.35 9.79 58 360896 33299 110195046
Conjunctival haemorrhage 14.35 9.79 51 360903 6582 110221763
Coating in mouth 14.34 9.79 10 360944 286 110228059
Anger 14.32 9.79 25 360929 18982 110209363
Pylorus dilatation 14.30 9.79 5 360949 28 110228317
Urate nephropathy 14.25 9.79 9 360945 217 110228128
Pustular psoriasis 14.25 9.79 14 360940 13591 110214754
B-cell unclassifiable lymphoma high grade 14.23 9.79 4 360950 9 110228336
Gastric ulcer haemorrhage 14.22 9.79 68 360886 10026 110218319
Body temperature decreased 14.20 9.79 67 360887 36868 110191477
Tongue oedema 14.19 9.79 59 360895 8197 110220148
Oesophageal mucosal blister 14.18 9.79 3 360951 0 110228345
Persistent generalised lymphadenopathy 14.18 9.79 3 360951 0 110228345
Inflammation scan 14.18 9.79 3 360951 0 110228345
Rheumatoid nodule 14.13 9.79 28 360926 20268 110208077
Surgery 14.11 9.79 78 360876 41205 110187140
Prostatitis 14.11 9.79 41 360913 4760 110223585
Stasis dermatitis 14.06 9.79 23 360931 1799 110226546
Craniofacial fracture 14.04 9.79 16 360938 885 110227460
Metastases to nervous system 14.04 9.79 10 360944 296 110228049
Acid base balance abnormal 13.98 9.79 12 360942 469 110227876
Uveitic glaucoma 13.93 9.79 4 360950 10 110228335
Lymphopenia 13.92 9.79 196 360758 39974 110188371
Spondylitis 13.92 9.79 10 360944 11328 110217017
Retinal thickening 13.92 9.79 10 360944 300 110228045
Pelvic pain 13.89 9.79 19 360935 15923 110212422
Fear of falling 13.87 9.79 16 360938 897 110227448
Necrotising ulcerative gingivostomatitis 13.84 9.79 6 360948 64 110228281
Acute graft versus host disease in skin 13.82 9.79 9 360945 10731 110217614
Antipsychotic drug level increased 13.80 9.79 3 360951 7012 110221333
Subclavian artery occlusion 13.77 9.79 8 360946 165 110228180
Peptic ulcer haemorrhage 13.69 9.79 18 360936 1155 110227190
Systemic inflammatory response syndrome 13.68 9.79 81 360873 12962 110215383
Fluid intake reduced 13.67 9.79 52 360902 6934 110221411
Myopathy 13.66 9.79 133 360821 24827 110203518
Ileus 13.66 9.79 157 360797 30572 110197773
Hyperparathyroidism 13.65 9.79 35 360919 3775 110224570
Uraemic encephalopathy 13.65 9.79 15 360939 797 110227548
Eyelid oedema 13.65 9.79 91 360863 15171 110213174
Oral mucosal eruption 13.64 9.79 18 360936 1159 110227186
Conjunctival hyperaemia 13.63 9.79 46 360908 5785 110222560
Vascular malformation 13.62 9.79 15 360939 799 110227546
Back disorder 13.61 9.79 30 360924 20892 110207453
Ventricular extrasystoles 13.57 9.79 123 360831 22518 110205827
Tooth deposit 13.55 9.79 10 360944 313 110228032
Enterococcal sepsis 13.54 9.79 32 360922 3280 110225065
Pharyngitis streptococcal 13.52 9.79 14 360940 13263 110215082
Hyperthermia 13.49 9.79 117 360837 21155 110207190
Bile duct stone 13.30 9.79 48 360906 6241 110222104
Haemorrhoidal haemorrhage 13.26 9.79 57 360897 8036 110220309
Generalised oedema 13.26 9.79 156 360798 30548 110197797
Intercepted product preparation error 13.25 9.79 3 360951 6817 110221528
Initial insomnia 13.23 9.79 68 360886 10321 110218024
Metastases to spleen 13.18 9.79 15 360939 829 110227516
Alanine aminotransferase abnormal 13.17 9.79 7 360947 9327 110219018
Nephritis 13.17 9.79 47 360907 6079 110222266
Crepitations 13.16 9.79 70 360884 10765 110217580
Abnormal clotting factor 13.16 9.79 8 360946 180 110228165
Aortic valve disease 13.15 9.79 25 360929 2202 110226143
Hysterectomy 13.15 9.79 5 360949 8109 110220236
Scrotal erythema 13.12 9.79 5 360949 37 110228308
Granulomatous dermatitis 13.05 9.79 12 360942 514 110227831
Heat stroke 13.04 9.79 23 360931 1912 110226433
Mouth haemorrhage 13.03 9.79 82 360872 13406 110214939
Weight decreased 13.02 9.79 1333 359621 466724 109761621
Oxygen consumption decreased 13.01 9.79 12 360942 516 110227829
Maternal condition affecting foetus 13.00 9.79 8 360946 184 110228161
Metabolic alkalosis 12.96 9.79 44 360910 5551 110222794
Muscle necrosis 12.95 9.79 22 360932 1775 110226570
Atrioventricular block second degree 12.93 9.79 57 360897 8124 110220221
Morganella test positive 12.89 9.79 5 360949 39 110228306
Neutropenic infection 12.88 9.79 31 360923 3214 110225131
Enthesopathy 12.88 9.79 13 360941 12465 110215880
Incorrect product administration duration 12.84 9.79 30 360924 20468 110207877
Large intestine polyp 12.84 9.79 89 360865 15028 110213317
Spontaneous haematoma 12.82 9.79 23 360931 1938 110226407
Temperature intolerance 12.80 9.79 16 360938 13934 110214411
Malignant transformation 12.79 9.79 20 360934 1505 110226840
Swelling of eyelid 12.78 9.79 3 360951 6650 110221695
Administration site discomfort 12.77 9.79 8 360946 190 110228155
Coordination abnormal 12.76 9.79 41 360913 25187 110203158
Upper-airway cough syndrome 12.74 9.79 20 360934 15837 110212508
Ichthyosis acquired 12.73 9.79 4 360950 15 110228330
Oesophagobronchial fistula 12.68 9.79 9 360945 265 110228080
Retinal haemorrhage 12.67 9.79 63 360891 9438 110218907
Rash papular 12.64 9.79 142 360812 27497 110200848
Occult blood positive 12.63 9.79 53 360901 7392 110220953
Ulcer haemorrhage 12.62 9.79 35 360919 22536 110205809
Post-traumatic stress disorder 12.62 9.79 3 360951 6593 110221752
Injection site discolouration 12.59 9.79 7 360947 9096 110219249
Cytogenetic analysis abnormal 12.59 9.79 18 360936 1251 110227094
Arteriospasm coronary 12.59 9.79 7 360947 9093 110219252
Carcinoma in situ of skin 12.56 9.79 8 360946 196 110228149
Gastroenteritis 12.53 9.79 187 360767 38613 110189732
Splenic infarction 12.51 9.79 37 360917 4337 110224008
Gastric ulcer 12.49 9.79 191 360763 39636 110188709
Arteriovenous fistula operation 12.49 9.79 10 360944 354 110227991
Bacterial sepsis 12.42 9.79 67 360887 10359 110217986
Immunosuppressant drug level increased 12.42 9.79 73 360881 11651 110216694
Hyperchromic anaemia 12.38 9.79 8 360946 201 110228144
Suspected suicide 12.38 9.79 19 360935 15180 110213165
Papillary renal cell carcinoma 12.37 9.79 10 360944 359 110227986
Paranasal cyst 12.34 9.79 15 360939 889 110227456
Hyperviscosity syndrome 12.32 9.79 12 360942 553 110227792
Acidosis 12.30 9.79 120 360834 22411 110205934
Mucormycosis 12.25 9.79 10 360944 10618 110217727
Implant site inflammation 12.24 9.79 9 360945 280 110228065
Diverticulum oesophageal 12.24 9.79 8 360946 205 110228140
Skin reaction 12.23 9.79 114 360840 21030 110207315
Xanthopsia 12.23 9.79 10 360944 365 110227980
Coagulation test abnormal 12.21 9.79 20 360934 1566 110226779
Duodenal ulcer 12.20 9.79 107 360847 19407 110208938
Superinfection 12.20 9.79 44 360910 5719 110222626
Diverticular perforation 12.16 9.79 47 360907 6315 110222030
Ventricular arrhythmia 12.14 9.79 65 360889 10022 110218323
Blood uric acid 12.12 9.79 3 360951 3 110228342
Vulvovaginal adhesion 12.12 9.79 3 360951 3 110228342
Interstitial granulomatous dermatitis 12.11 9.79 9 360945 285 110228060
Mucosal necrosis 12.10 9.79 8 360946 209 110228136
Proctitis 12.09 9.79 23 360931 16904 110211441
Aortic valve sclerosis 12.04 9.79 22 360932 1881 110226464
Viral infection 12.03 9.79 113 360841 53026 110175319
Respiratory fatigue 12.00 9.79 9 360945 289 110228056
Rash erythematous 11.99 9.79 351 360603 81481 110146864
Lacrimation increased 11.98 9.79 56 360898 30894 110197451
Oral herpes 11.88 9.79 69 360885 36011 110192334
Pulmonary sarcoidosis 11.86 9.79 21 360933 1751 110226594
Aplasia 11.80 9.79 54 360900 7819 110220526
Tenosynovitis stenosans 11.79 9.79 32 360922 3571 110224774
Spontaneous haemorrhage 11.79 9.79 17 360937 1191 110227154
Symblepharon 11.77 9.79 11 360943 481 110227864
Hydrocholecystis 11.76 9.79 12 360942 585 110227760
Ovarian cyst 11.74 9.79 17 360937 13913 110214432
Portal vein flow decreased 11.73 9.79 5 360949 51 110228294
Transplant rejection 11.69 9.79 41 360913 24526 110203819
Marrow hyperplasia 11.66 9.79 21 360933 1775 110226570
Necrotic angiodermatitis 11.66 9.79 3 360951 4 110228341
Xerosis 11.64 9.79 20 360934 1629 110226716
Encephalitis 11.63 9.79 103 360851 18736 110209609
Gastric perforation 11.62 9.79 39 360915 4890 110223455
Tachycardia induced cardiomyopathy 11.62 9.79 8 360946 224 110228121
Brain oedema 11.61 9.79 57 360897 31041 110197304
Haemorrhagic stroke 11.61 9.79 81 360873 13708 110214637
Injection site induration 11.59 9.79 12 360942 11371 110216974
Acute graft versus host disease 11.58 9.79 15 360939 12866 110215479
Gingival pain 11.58 9.79 21 360933 15715 110212630
Total lung capacity decreased 11.57 9.79 50 360904 7064 110221281
Bladder dilatation 11.57 9.79 25 360929 2414 110225931
Hydrothorax 11.56 9.79 20 360934 1638 110226707
Product used for unknown indication 11.55 9.79 22 360932 1941 110226404
Drug therapeutic incompatibility 11.53 9.79 7 360947 157 110228188
Carcinogenicity 11.53 9.79 7 360947 157 110228188
Tongue disorder 11.52 9.79 18 360936 14280 110214065
Retroperitoneal haematoma 11.48 9.79 45 360909 6086 110222259
Acquired epidermolysis bullosa 11.47 9.79 6 360948 100 110228245
Genital infection 11.46 9.79 8 360946 229 110228116
Duodenal stenosis 11.42 9.79 15 360939 962 110227383
Gastric haemorrhage 11.41 9.79 90 360864 15825 110212520
Blast cells present 11.40 9.79 15 360939 963 110227382
Orthostatic intolerance 11.39 9.79 23 360931 2118 110226227
Hypoaesthesia oral 11.38 9.79 24 360930 16978 110211367
Bladder tamponade 11.35 9.79 13 360941 723 110227622
N-terminal prohormone brain natriuretic peptide abnormal 11.35 9.79 9 360945 314 110228031
Product dose omission in error 11.35 9.79 39 360915 23473 110204872
Calculus urinary 11.34 9.79 29 360925 3123 110225222
Neurological symptom 11.33 9.79 21 360933 15587 110212758
Skin turgor decreased 11.30 9.79 14 360940 846 110227499
Reactive gastropathy 11.28 9.79 13 360941 728 110227617
Angina unstable 11.28 9.79 92 360862 16340 110212005
Nephropathy 11.27 9.79 79 360875 13388 110214957
Acute lymphocytic leukaemia recurrent 11.26 9.79 43 360911 5744 110222601
Carpal tunnel syndrome 11.25 9.79 37 360917 22573 110205772
Bladder hypertrophy 11.23 9.79 16 360938 1108 110227237
Acute leukaemia 11.22 9.79 21 360933 1828 110226517
Product storage error 11.20 9.79 35 360919 21693 110206652
Nausea 11.20 9.79 3738 357216 1231952 108996393
Coronary artery aneurysm 11.19 9.79 7 360947 166 110228179
Device use error 11.18 9.79 8 360946 9081 110219264
Cystitis 11.17 9.79 150 360804 65886 110162459
Ventricular internal diameter abnormal 11.17 9.79 8 360946 239 110228106
Mucosal inflammation 11.14 9.79 401 360553 95740 110132605
Wrist deformity 11.12 9.79 29 360925 3160 110225185
Faecal calprotectin increased 11.12 9.79 4 360950 6715 110221630
Mucosal haemorrhage 11.09 9.79 28 360926 2992 110225353
Staphylococcal infection 11.08 9.79 303 360651 69641 110158704
Parakeratosis 11.06 9.79 11 360943 520 110227825
Alcohol poisoning 11.02 9.79 8 360946 9012 110219333
Prothrombin time abnormal 11.02 9.79 17 360937 1265 110227080
Retroperitoneal fibrosis 11.02 9.79 13 360941 747 110227598
Retinal disorder 10.91 9.79 24 360930 2346 110225999
Corynebacterium sepsis 10.91 9.79 8 360946 248 110228097
Endocarditis candida 10.91 9.79 6 360948 111 110228234
Deficiency anaemia 10.91 9.79 6 360948 111 110228234
Cerebellar stroke 10.90 9.79 14 360940 878 110227467
Cholecystitis chronic 10.88 9.79 9 360945 9491 110218854
Obsessive-compulsive disorder 10.87 9.79 5 360949 7236 110221109
Alpha haemolytic streptococcal infection 10.86 9.79 31 360923 3562 110224783
Peritonitis 10.86 9.79 158 360796 32449 110195896
Cholangiocarcinoma 10.86 9.79 27 360927 2858 110225487
Dry eye 10.84 9.79 123 360831 55670 110172675
Fear 10.84 9.79 39 360915 23154 110205191
Upper respiratory tract infection 10.84 9.79 336 360618 130992 110097353
Scratch 10.79 9.79 16 360938 12963 110215382
Costal cartilage fracture 10.77 9.79 8 360946 253 110228092
Scleral haemorrhage 10.76 9.79 7 360947 178 110228167
Blood fibrinogen increased 10.74 9.79 22 360932 2046 110226299
Adenovirus infection 10.74 9.79 12 360942 10982 110217363
Productive cough 10.73 9.79 466 360488 113839 110114506
Depressed mood 10.70 9.79 137 360817 60672 110167673
Crystal arthropathy 10.69 9.79 8 360946 256 110228089
Blood hyposmosis 10.69 9.79 4 360950 28 110228317
Irritability 10.68 9.79 102 360852 47707 110180638
Cardiorenal syndrome 10.68 9.79 21 360933 1897 110226448
Conjunctival scar 10.68 9.79 9 360945 343 110228002
B-cell lymphoma 10.67 9.79 49 360905 7105 110221240
Graft versus host disease 10.64 9.79 29 360925 18777 110209568
Transfusion reaction 10.62 9.79 22 360932 2063 110226282
Drooling 10.61 9.79 5 360949 7134 110221211
Intentional dose omission 10.60 9.79 32 360922 20048 110208297
Prolymphocytic leukaemia 10.60 9.79 3 360951 7 110228338
Complication associated with device 10.59 9.79 32 360922 20041 110208304
Aggression 10.56 9.79 133 360821 59077 110169268
Hereditary angioedema 10.54 9.79 5 360949 7109 110221236
Dermatitis 10.54 9.79 138 360816 27699 110200646
Pallor 10.53 9.79 250 360704 56217 110172128
Nasal mucosal erosion 10.52 9.79 5 360949 67 110228278
Salivary gland cancer stage IV 10.52 9.79 5 360949 67 110228278
Ileus paralytic 10.51 9.79 70 360884 11667 110216678
Lactose intolerance 10.47 9.79 26 360928 2750 110225595
Paraneoplastic syndrome 10.44 9.79 17 360937 1325 110227020
Mastoiditis 10.43 9.79 25 360929 2586 110225759
Renal tubular atrophy 10.42 9.79 23 360931 2253 110226092
Dysphoria 10.35 9.79 4 360950 6424 110221921
Intermittent claudication 10.30 9.79 31 360923 3670 110224675
Dilatation ventricular 10.29 9.79 33 360921 4042 110224303
Transplant failure 10.26 9.79 41 360913 5594 110222751
Hospitalisation 10.25 9.79 371 360583 142122 110086223
Mastication disorder 10.19 9.79 30 360924 3508 110224837
Faeces pale 10.18 9.79 29 360925 3328 110225017
Secretion discharge 10.17 9.79 33 360921 20211 110208134
Hepatotoxicity 10.14 9.79 275 360679 63125 110165220
Bladder transitional cell carcinoma stage II 10.14 9.79 5 360949 73 110228272
Asthma-chronic obstructive pulmonary disease overlap syndrome 10.13 9.79 4 360950 6340 110222005
Blood pressure diastolic decreased 10.10 9.79 72 360882 35813 110192532
Cholecystitis 10.09 9.79 129 360825 25753 110202592
Transient ischaemic attack 10.09 9.79 277 360677 63705 110164640
Spinal fusion surgery 10.08 9.79 9 360945 9147 110219198
Colon neoplasm 10.07 9.79 14 360940 948 110227397
Cardiac disorder 10.06 9.79 323 360631 75957 110152388
Pseudohyperkalaemia 10.06 9.79 3 360951 9 110228336
Light chain disease 10.05 9.79 8 360946 281 110228064
Injection site extravasation 10.04 9.79 11 360943 10158 110218187
B-cell small lymphocytic lymphoma 10.04 9.79 7 360947 200 110228145
Wrong technique in device usage process 10.00 9.79 5 360949 6896 110221449
Mucocutaneous haemorrhage 10.00 9.79 8 360946 283 110228062
Synovial fluid analysis 10.00 9.79 25 360929 2656 110225689
Mesenteric panniculitis 9.94 9.79 11 360943 589 110227756
Mucosal discolouration 9.93 9.79 14 360940 960 110227385
Anticoagulation drug level decreased 9.93 9.79 8 360946 286 110228059
JC virus CSF test positive 9.92 9.79 7 360947 204 110228141
Enterobacter pneumonia 9.87 9.79 11 360943 594 110227751
Anaemia megaloblastic 9.87 9.79 13 360941 836 110227509
International normalised ratio decreased 9.86 9.79 53 360901 8183 110220162
Polyneuropathy 9.84 9.79 153 360801 31859 110196486
Escherichia infection 9.84 9.79 120 360834 23696 110204649
Tonsillar haemorrhage 9.83 9.79 8 360946 290 110228055
Spermatocele 9.82 9.79 3 360951 10 110228335
Nephrotic syndrome 9.80 9.79 78 360876 13753 110214592
Neuritis 9.80 9.79 6 360948 7393 110220952

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M04AA01 MUSCULO-SKELETAL SYSTEM
ANTIGOUT PREPARATIONS
ANTIGOUT PREPARATIONS
Preparations inhibiting uric acid production
ATC M04AA51 MUSCULO-SKELETAL SYSTEM
ANTIGOUT PREPARATIONS
ANTIGOUT PREPARATIONS
Preparations inhibiting uric acid production
FDA MoA N0000000206 Xanthine Oxidase Inhibitors
MeSH PA D000963 Antimetabolites
MeSH PA D000975 Antioxidants
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D006074 Gout Suppressants
MeSH PA D016166 Free Radical Scavengers
MeSH PA D018501 Antirheumatic Agents
FDA EPC N0000175698 Xanthine Oxidase Inhibitor
CHEBI has role CHEBI:33231 antitubercular agent
CHEBI has role CHEBI:35221 antimetabolite
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35634 EC 1.17.3.2 (xanthine oxidase) inhibitor
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35845 gout suppressant
CHEBI has role CHEBI:48578 radical scavenger
CHEBI has role CHEBI:62868 hepatoprotective agent
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:70868 antileishmanial agent
CHEBI has role CHEBI:73336 vulnerary
CHEBI has role CHEBI:74518 anti-obesity agent

Related Drugs by ATC class:

M04AA Preparations inhibiting uric acid production 2 drugs
febuxostattisopurine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hyperuricemia indication 35885006 DOID:1920
Articular gout indication 48440001 DOID:13189
Gout indication 90560007 DOID:13189
Uric acid renal calculus indication 274401005
Calcium renal calculus indication 427649000
Uric Acid Nephropathy Gout indication
Chemotherapy-Induced Hyperuricemia indication
Recurrent Calcium Renal Calculi indication
Adjunctive treatment for bipolar disorder off-label use 13746004 DOID:3312
Deficiency of adenine phosphoribosyltransferase off-label use 124274002 DOID:0060350
Deficiency of ribose-phosphate pyrophosphokinase off-label use 124343001
Neonatal Phosphoribosylpyrophosphate Synthetase Superactivity off-label use
Dehydration contraindication 34095006
Chronic heart failure contraindication 48447003
Hypersensitivity angiitis contraindication 60555002
Impaired renal function disorder contraindication 197663003
Disease of liver contraindication 235856003 DOID:409




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.52 acidic
pKa2 9.43 acidic
pKa3 1.45 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
200MG;200MG DUZALLO IRONWOOD PHARMS INC N209203 Aug. 18, 2017 DISCN TABLET ORAL 10183012 Nov. 26, 2028 TREATMENT OF HYPERURICEMIA ASSOCIATED WITH GOUT IN PATIENTS WHO HAVE NOT ACHIEVED TARGET SERUM URIC ACID LEVELS WITH A MEDICALLY APPROPRIATE DAILY DOSE OF ALLOPURINOL ALONE
200MG;200MG DUZALLO IRONWOOD PHARMS INC N209203 Aug. 18, 2017 DISCN TABLET ORAL 8283369 Nov. 26, 2028 TREATMENT OF HYPERURICEMIA ASSOCIATED WITH GOUT IN PATIENTS WHO HAVE NOT ACHIEVED TARGET SERUM URIC ACID LEVELS WITH A MEDICALLY APPROPRIATE DAILY DOSE OF ALLOPURINOL ALONE
300MG;200MG DUZALLO IRONWOOD PHARMS INC N209203 Aug. 18, 2017 DISCN TABLET ORAL 10183012 Nov. 26, 2028 TREATMENT OF HYPERURICEMIA ASSOCIATED WITH GOUT IN PATIENTS WHO HAVE NOT ACHIEVED TARGET SERUM URIC ACID LEVELS WITH A MEDICALLY APPROPRIATE DAILY DOSE OF ALLOPURINOL ALONE
300MG;200MG DUZALLO IRONWOOD PHARMS INC N209203 Aug. 18, 2017 DISCN TABLET ORAL 8283369 Nov. 26, 2028 TREATMENT OF HYPERURICEMIA ASSOCIATED WITH GOUT IN PATIENTS WHO HAVE NOT ACHIEVED TARGET SERUM URIC ACID LEVELS WITH A MEDICALLY APPROPRIATE DAILY DOSE OF ALLOPURINOL ALONE
200MG;200MG DUZALLO IRONWOOD PHARMS INC N209203 Aug. 18, 2017 DISCN TABLET ORAL 8546437 April 29, 2029 TREATMENT OF HYPERURICEMIA ASSOCIATED WITH GOUT IN PATIENTS WHO HAVE NOT ACHIEVED TARGET SERUM URIC ACID LEVELS WITH A MEDICALLY APPROPRIATE DAILY DOSE OF ALLOPURINOL ALONE
300MG;200MG DUZALLO IRONWOOD PHARMS INC N209203 Aug. 18, 2017 DISCN TABLET ORAL 8546437 April 29, 2029 TREATMENT OF HYPERURICEMIA ASSOCIATED WITH GOUT IN PATIENTS WHO HAVE NOT ACHIEVED TARGET SERUM URIC ACID LEVELS WITH A MEDICALLY APPROPRIATE DAILY DOSE OF ALLOPURINOL ALONE
200MG;200MG DUZALLO IRONWOOD PHARMS INC N209203 Aug. 18, 2017 DISCN TABLET ORAL 8084483 Aug. 17, 2029 TREATMENT OF HYPERURICEMIA ASSOCIATED WITH GOUT IN PATIENTS WHO HAVE NOT ACHIEVED TARGET SERUM URIC ACID LEVELS WITH A MEDICALLY APPROPRIATE DAILY DOSE OF ALLOPURINOL ALONE
300MG;200MG DUZALLO IRONWOOD PHARMS INC N209203 Aug. 18, 2017 DISCN TABLET ORAL 8084483 Aug. 17, 2029 TREATMENT OF HYPERURICEMIA ASSOCIATED WITH GOUT IN PATIENTS WHO HAVE NOT ACHIEVED TARGET SERUM URIC ACID LEVELS WITH A MEDICALLY APPROPRIATE DAILY DOSE OF ALLOPURINOL ALONE
200MG;200MG DUZALLO IRONWOOD PHARMS INC N209203 Aug. 18, 2017 DISCN TABLET ORAL 8357713 Dec. 22, 2029 TREATMENT OF HYPERURICEMIA ASSOCIATED WITH GOUT IN PATIENTS WHO HAVE NOT ACHIEVED TARGET SERUM URIC ACID LEVELS WITH A MEDICALLY APPROPRIATE DAILY DOSE OF ALLOPURINOL ALONE
300MG;200MG DUZALLO IRONWOOD PHARMS INC N209203 Aug. 18, 2017 DISCN TABLET ORAL 8357713 Dec. 22, 2029 TREATMENT OF HYPERURICEMIA ASSOCIATED WITH GOUT IN PATIENTS WHO HAVE NOT ACHIEVED TARGET SERUM URIC ACID LEVELS WITH A MEDICALLY APPROPRIATE DAILY DOSE OF ALLOPURINOL ALONE
200MG;200MG DUZALLO IRONWOOD PHARMS INC N209203 Aug. 18, 2017 DISCN TABLET ORAL 9216179 Aug. 1, 2031 TREATMENT OF HYPERURICEMIA ASSOCIATED WITH GOUT IN PATIENTS WHO HAVE NOT ACHIEVED TARGET SERUM URIC ACID LEVELS WITH A MEDICALLY APPROPRIATE DAILY DOSE OF ALLOPURINOL ALONE
300MG;200MG DUZALLO IRONWOOD PHARMS INC N209203 Aug. 18, 2017 DISCN TABLET ORAL 9216179 Aug. 1, 2031 TREATMENT OF HYPERURICEMIA ASSOCIATED WITH GOUT IN PATIENTS WHO HAVE NOT ACHIEVED TARGET SERUM URIC ACID LEVELS WITH A MEDICALLY APPROPRIATE DAILY DOSE OF ALLOPURINOL ALONE
200MG;200MG DUZALLO IRONWOOD PHARMS INC N209203 Aug. 18, 2017 DISCN TABLET ORAL 9956205 Dec. 28, 2031 TREATMENT OF HYPERURICEMIA ASSOCIATED WITH GOUT IN PATIENTS WHO HAVE NOT ACHIEVED TARGET SERUM URIC ACID LEVELS WITH A MEDICALLY APPROPRIATE DAILY DOSE OF ALLOPURINOL ALONE
300MG;200MG DUZALLO IRONWOOD PHARMS INC N209203 Aug. 18, 2017 DISCN TABLET ORAL 9956205 Dec. 28, 2031 TREATMENT OF HYPERURICEMIA ASSOCIATED WITH GOUT IN PATIENTS WHO HAVE NOT ACHIEVED TARGET SERUM URIC ACID LEVELS WITH A MEDICALLY APPROPRIATE DAILY DOSE OF ALLOPURINOL ALONE

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Xanthine dehydrogenase/oxidase Enzyme INHIBITOR Ki 5.15 CHEMBL CHEMBL
Hypoxanthine-guanine phosphoribosyltransferase Enzyme WOMBAT-PK
Adenosine receptor A2a GPCR Kd 4.11 CHEMBL
Xanthine dehydrogenase/oxidase Enzyme IC50 6.12 CHEMBL
Replicase polyprotein 1ab Enzyme IC50 5.42 CHEMBL
Shiga toxin subunit A Ribosomal protein IC50 4.62 CHEMBL
Xanthine dehydrogenase/oxidase Enzyme Ki 6 CHEMBL

External reference:

IDSource
4017895 VUID
N0000146247 NUI
D00224 KEGG_DRUG
203600 RXNORM
C0002144 UMLSCUI
CHEBI:40279 CHEBI
CHEMBL1467 ChEMBL_ID
135401907 PUBCHEM_CID
DB00437 DRUGBANK_ID
CHEMBL1200477 ChEMBL_ID
D000493 MESH_DESCRIPTOR_UI
1731 INN_ID
6795 IUPHAR_LIGAND_ID
17795-21-0 SECONDARY_CAS_RN
63CZ7GJN5I UNII
1590 MMSL
1816 MMSL
4150 MMSL
8255 MMSL
8256 MMSL
d00023 MMSL
A1BD4 PDB_CHEM_ID
4017895 VANDF
001084 NDDF
005000 NDDF
25246002 SNOMEDCT_US
387135004 SNOMEDCT_US
425496004 SNOMEDCT_US
63CZ7GJN5I INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Allopurinol sodium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9533 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 500 mg INTRAVENOUS ANDA 26 sections
Allopurinol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0137 TABLET 100 mg ORAL ANDA 24 sections
Allopurinol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0181 TABLET 300 mg ORAL ANDA 24 sections
Allopurinol HUMAN PRESCRIPTION DRUG LABEL 1 0591-5543 TABLET 100 mg ORAL NDA 24 sections
Allopurinol HUMAN PRESCRIPTION DRUG LABEL 1 0591-5544 TABLET 300 mg ORAL NDA 24 sections
Allopurinol HUMAN PRESCRIPTION DRUG LABEL 1 0603-2115 TABLET 100 mg ORAL ANDA 23 sections
Allopurinol HUMAN PRESCRIPTION DRUG LABEL 1 0603-2116 TABLET 300 mg ORAL ANDA 23 sections
Allopurinol HUMAN PRESCRIPTION DRUG LABEL 1 0615-8385 TABLET 100 mg ORAL ANDA 23 sections
Allopurinol HUMAN PRESCRIPTION DRUG LABEL 1 0615-8517 TABLET 300 mg ORAL ANDA 23 sections
Allopurinol HUMAN PRESCRIPTION DRUG LABEL 1 0904-6572 TABLET 300 mg ORAL ANDA 23 sections
Allopurinol HUMAN PRESCRIPTION DRUG LABEL 1 0904-7041 TABLET 100 mg ORAL ANDA 22 sections
Allopurinol HUMAN PRESCRIPTION DRUG LABEL 1 10544-545 TABLET 100 mg ORAL ANDA 17 sections
Allopurinol HUMAN PRESCRIPTION DRUG LABEL 1 10544-547 TABLET 300 mg ORAL ANDA 17 sections
Allopurinol HUMAN PRESCRIPTION DRUG LABEL 1 10544-911 TABLET 300 mg ORAL ANDA 19 sections
Allopurinol Human Prescription Drug Label 1 14445-170 TABLET 100 mg ORAL ANDA 22 sections
Allopurinol Human Prescription Drug Label 1 14445-171 TABLET 300 mg ORAL ANDA 22 sections
Allopurinol Human Prescription Drug Label 1 14445-172 TABLET 200 mg ORAL ANDA 22 sections
Allopurinol Human Prescription Drug Label 1 16571-883 TABLET 100 mg ORAL NDA AUTHORIZED GENERIC 23 sections
Allopurinol Human Prescription Drug Label 1 16571-884 TABLET 200 mg ORAL NDA AUTHORIZED GENERIC 23 sections
Allopurinol Human Prescription Drug Label 1 16571-885 TABLET 300 mg ORAL NDA AUTHORIZED GENERIC 23 sections
Allopurinol Human Prescription Drug Label 1 16714-576 TABLET 100 mg ORAL ANDA 22 sections
Allopurinol Human Prescription Drug Label 1 16714-577 TABLET 300 mg ORAL ANDA 22 sections
Allopurinol HUMAN PRESCRIPTION DRUG LABEL 1 16729-134 TABLET 100 mg ORAL ANDA 23 sections
Allopurinol HUMAN PRESCRIPTION DRUG LABEL 1 16729-134 TABLET 100 mg ORAL ANDA 23 sections
Allopurinol HUMAN PRESCRIPTION DRUG LABEL 1 16729-135 TABLET 300 mg ORAL ANDA 23 sections
Allopurinol HUMAN PRESCRIPTION DRUG LABEL 1 16729-135 TABLET 300 mg ORAL ANDA 23 sections
Allopurinol HUMAN PRESCRIPTION DRUG LABEL 1 21695-246 TABLET 300 mg ORAL ANDA 21 sections
Allopurinol HUMAN PRESCRIPTION DRUG LABEL 1 21695-836 TABLET 100 mg ORAL ANDA 21 sections
Allopurinol Human Prescription Drug Label 1 23155-693 TABLET 100 mg ORAL ANDA 22 sections
Allopurinol Human Prescription Drug Label 1 23155-694 TABLET 300 mg ORAL ANDA 22 sections