Stem definition | Drug id | CAS RN |
---|---|---|
124 | 315-30-0 |
Dose | Unit | Route |
---|---|---|
0.40 | g | O |
0.40 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.57 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 12 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 97.71 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 53 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.58 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 11 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.97 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 0.80 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Aug. 19, 1966 | FDA | PROMETHEUS LABS |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug reaction with eosinophilia and systemic symptoms | 1776.82 | 10.13 | 987 | 100640 | 28561 | 46555874 |
Acute kidney injury | 586.89 | 10.13 | 1463 | 100164 | 234392 | 46350043 |
Drug ineffective | 409.39 | 10.13 | 528 | 101099 | 677310 | 45907125 |
Toxic epidermal necrolysis | 336.44 | 10.13 | 322 | 101305 | 21956 | 46562479 |
Stevens-Johnson syndrome | 322.40 | 10.13 | 321 | 101306 | 22976 | 46561459 |
Febrile neutropenia | 276.68 | 10.13 | 626 | 101001 | 94001 | 46490434 |
Renal failure | 271.49 | 10.13 | 695 | 100932 | 112899 | 46471536 |
Anaemia | 269.56 | 10.13 | 1186 | 100441 | 254593 | 46329842 |
Rheumatoid arthritis | 261.70 | 10.13 | 98 | 101529 | 240117 | 46344318 |
Gout | 243.01 | 10.13 | 200 | 101427 | 11156 | 46573279 |
Tumour lysis syndrome | 222.15 | 10.13 | 158 | 101469 | 7078 | 46577357 |
Hyperkalaemia | 205.48 | 10.13 | 384 | 101243 | 50325 | 46534110 |
Rash maculo-papular | 183.59 | 10.13 | 263 | 101364 | 27611 | 46556824 |
Pancytopenia | 178.38 | 10.13 | 496 | 101131 | 84562 | 46499873 |
Completed suicide | 171.89 | 10.13 | 52 | 101575 | 145868 | 46438567 |
Melaena | 168.38 | 10.13 | 252 | 101375 | 27520 | 46556915 |
Cardiac failure | 149.06 | 10.13 | 447 | 101180 | 79501 | 46504934 |
Renal impairment | 147.42 | 10.13 | 425 | 101202 | 73947 | 46510488 |
Pain | 145.15 | 10.13 | 542 | 101085 | 476406 | 46108029 |
Thrombocytopenia | 143.76 | 10.13 | 601 | 101026 | 125980 | 46458455 |
Hyperuricaemia | 142.50 | 10.13 | 102 | 101525 | 4615 | 46579820 |
Blood creatinine increased | 137.57 | 10.13 | 422 | 101205 | 75981 | 46508454 |
General physical health deterioration | 132.48 | 10.13 | 551 | 101076 | 115218 | 46469217 |
Cytokine release syndrome | 119.53 | 10.13 | 103 | 101524 | 6120 | 46578315 |
Atrial fibrillation | 116.91 | 10.13 | 491 | 101136 | 103099 | 46481336 |
Exposure during pregnancy | 114.60 | 10.13 | 46 | 101581 | 108166 | 46476269 |
Sepsis | 112.62 | 10.13 | 589 | 101038 | 135425 | 46449010 |
Platelet count decreased | 108.15 | 10.13 | 468 | 101159 | 99556 | 46484879 |
Treatment failure | 102.85 | 10.13 | 37 | 101590 | 93050 | 46491385 |
Haemoglobin decreased | 101.68 | 10.13 | 551 | 101076 | 128398 | 46456037 |
Bradycardia | 101.07 | 10.13 | 346 | 101281 | 65952 | 46518483 |
Pyrexia | 100.42 | 10.13 | 1180 | 100447 | 347622 | 46236813 |
Drug hypersensitivity | 99.11 | 10.13 | 242 | 101385 | 243583 | 46340852 |
Drug interaction | 98.76 | 10.13 | 768 | 100859 | 202326 | 46382109 |
Maternal exposure during pregnancy | 97.08 | 10.13 | 51 | 101576 | 102498 | 46481937 |
Headache | 94.04 | 10.13 | 633 | 100994 | 477719 | 46106716 |
International normalised ratio increased | 90.05 | 10.13 | 265 | 101362 | 46618 | 46537817 |
Neutropenic sepsis | 89.65 | 10.13 | 122 | 101505 | 12202 | 46572233 |
Injection site pain | 89.25 | 10.13 | 62 | 101565 | 107090 | 46477345 |
Toxic skin eruption | 87.66 | 10.13 | 121 | 101506 | 12266 | 46572169 |
Dehydration | 86.40 | 10.13 | 619 | 101008 | 158921 | 46425514 |
Chronic kidney disease | 86.25 | 10.13 | 239 | 101388 | 40632 | 46543803 |
Lactic acidosis | 85.58 | 10.13 | 212 | 101415 | 33697 | 46550738 |
Pemphigus | 85.12 | 10.13 | 3 | 101624 | 45271 | 46539164 |
Plasma cell myeloma | 82.20 | 10.13 | 248 | 101379 | 44230 | 46540205 |
Joint swelling | 81.56 | 10.13 | 148 | 101479 | 165925 | 46418510 |
Therapeutic product effect decreased | 81.30 | 10.13 | 39 | 101588 | 82562 | 46501873 |
Off label use | 77.91 | 10.13 | 496 | 101131 | 379345 | 46205090 |
Eosinophilia | 77.13 | 10.13 | 145 | 101482 | 19072 | 46565363 |
Intentional overdose | 76.68 | 10.13 | 23 | 101604 | 64921 | 46519514 |
Blood urea increased | 76.52 | 10.13 | 170 | 101457 | 25182 | 46559253 |
Neutropenia | 76.01 | 10.13 | 553 | 101074 | 142651 | 46441784 |
Blood uric acid increased | 75.59 | 10.13 | 67 | 101560 | 4134 | 46580301 |
Anxiety | 74.36 | 10.13 | 180 | 101447 | 181777 | 46402658 |
Arthralgia | 73.79 | 10.13 | 478 | 101149 | 364125 | 46220310 |
Product prescribing error | 72.80 | 10.13 | 145 | 101482 | 19902 | 46564533 |
Injection site erythema | 71.94 | 10.13 | 36 | 101591 | 74391 | 46510044 |
Hypotension | 71.34 | 10.13 | 797 | 100830 | 231792 | 46352643 |
Depression | 65.83 | 10.13 | 173 | 101454 | 169931 | 46414504 |
Drug intolerance | 65.31 | 10.13 | 139 | 101488 | 146910 | 46437525 |
Alopecia | 65.30 | 10.13 | 162 | 101465 | 162252 | 46422183 |
Contraindicated product administered | 64.28 | 10.13 | 48 | 101579 | 79899 | 46504536 |
Gastrointestinal haemorrhage | 61.87 | 10.13 | 332 | 101295 | 77041 | 46507394 |
Dilatation intrahepatic duct acquired | 61.66 | 10.13 | 31 | 101596 | 725 | 46583710 |
Systemic lupus erythematosus | 60.81 | 10.13 | 33 | 101594 | 65147 | 46519288 |
Oedema peripheral | 60.22 | 10.13 | 571 | 101056 | 159135 | 46425300 |
Hand deformity | 59.55 | 10.13 | 4 | 101623 | 34570 | 46549865 |
Acute myeloid leukaemia | 57.15 | 10.13 | 114 | 101513 | 15664 | 46568771 |
Arthropathy | 57.10 | 10.13 | 60 | 101567 | 84640 | 46499795 |
Abdominal discomfort | 56.77 | 10.13 | 156 | 101471 | 151009 | 46433426 |
Glossodynia | 55.59 | 10.13 | 14 | 101613 | 44359 | 46540076 |
Haematoma | 55.42 | 10.13 | 174 | 101453 | 31698 | 46552737 |
Multiple sclerosis relapse | 55.33 | 10.13 | 12 | 101615 | 42113 | 46542322 |
Abortion spontaneous | 54.23 | 10.13 | 14 | 101613 | 43632 | 46540803 |
Toxicity to various agents | 54.02 | 10.13 | 257 | 101370 | 211509 | 46372926 |
Injection site reaction | 51.19 | 10.13 | 20 | 101607 | 47829 | 46536606 |
Injection site pruritus | 50.84 | 10.13 | 12 | 101615 | 39731 | 46544704 |
Hypokalaemia | 50.80 | 10.13 | 347 | 101280 | 87677 | 46496758 |
Drug abuse | 49.78 | 10.13 | 39 | 101588 | 63369 | 46521066 |
Tubulointerstitial nephritis | 49.01 | 10.13 | 103 | 101524 | 14685 | 46569750 |
Therapeutic product effect incomplete | 48.71 | 10.13 | 59 | 101568 | 78094 | 46506341 |
Dermatitis exfoliative | 48.43 | 10.13 | 61 | 101566 | 5655 | 46578780 |
Cardioactive drug level increased | 47.71 | 10.13 | 38 | 101589 | 2021 | 46582414 |
Nasopharyngitis | 45.95 | 10.13 | 176 | 101451 | 153822 | 46430613 |
Suicidal ideation | 45.13 | 10.13 | 34 | 101593 | 56348 | 46528087 |
Hyponatraemia | 44.70 | 10.13 | 375 | 101252 | 100957 | 46483478 |
Face oedema | 44.42 | 10.13 | 116 | 101511 | 19037 | 46565398 |
Blood lactate dehydrogenase increased | 44.35 | 10.13 | 121 | 101506 | 20379 | 46564056 |
Sopor | 43.87 | 10.13 | 118 | 101509 | 19710 | 46564725 |
Splenomegaly | 43.82 | 10.13 | 77 | 101550 | 9611 | 46574824 |
Labelled drug-drug interaction medication error | 43.58 | 10.13 | 74 | 101553 | 8987 | 46575448 |
Injection site swelling | 42.90 | 10.13 | 17 | 101610 | 40310 | 46544125 |
Tumour flare | 42.53 | 10.13 | 18 | 101609 | 279 | 46584156 |
Chronic lymphocytic leukaemia | 42.03 | 10.13 | 41 | 101586 | 2859 | 46581576 |
Allergic reaction to excipient | 41.29 | 10.13 | 18 | 101609 | 301 | 46584134 |
Pneumonia | 41.17 | 10.13 | 1091 | 100536 | 375229 | 46209206 |
Epistaxis | 40.42 | 10.13 | 259 | 101368 | 64046 | 46520389 |
Sinusitis | 40.21 | 10.13 | 146 | 101481 | 129622 | 46454813 |
Skin exfoliation | 40.17 | 10.13 | 160 | 101467 | 32778 | 46551657 |
Seizure | 39.09 | 10.13 | 137 | 101490 | 122917 | 46461518 |
Blast crisis in myelogenous leukaemia | 39.01 | 10.13 | 20 | 101607 | 488 | 46583947 |
Shock haemorrhagic | 38.31 | 10.13 | 68 | 101559 | 8556 | 46575879 |
Psoriasis | 37.70 | 10.13 | 71 | 101556 | 78533 | 46505902 |
Asthenia | 37.57 | 10.13 | 914 | 100713 | 310161 | 46274274 |
Hypoglycaemia | 37.36 | 10.13 | 224 | 101403 | 54125 | 46530310 |
Rash morbilliform | 37.14 | 10.13 | 39 | 101588 | 2970 | 46581465 |
Suicide attempt | 37.07 | 10.13 | 39 | 101588 | 54997 | 46529438 |
Inappropriate schedule of product administration | 36.51 | 10.13 | 53 | 101574 | 64960 | 46519475 |
Injection site bruising | 36.33 | 10.13 | 16 | 101611 | 35620 | 46548815 |
Mucosal inflammation | 35.86 | 10.13 | 174 | 101453 | 38802 | 46545633 |
Breast cancer | 35.72 | 10.13 | 28 | 101599 | 45490 | 46538945 |
Dialysis | 35.33 | 10.13 | 72 | 101555 | 10044 | 46574391 |
Purpura | 34.93 | 10.13 | 71 | 101556 | 9887 | 46574548 |
Product use issue | 34.53 | 10.13 | 99 | 101528 | 94545 | 46489890 |
Intentional product misuse | 34.52 | 10.13 | 31 | 101596 | 47097 | 46537338 |
Multiple organ dysfunction syndrome | 34.19 | 10.13 | 211 | 101416 | 51499 | 46532936 |
Rheumatoid factor positive | 33.46 | 10.13 | 3 | 101624 | 20458 | 46563977 |
Fatigue | 33.29 | 10.13 | 1041 | 100586 | 607656 | 45976779 |
Pregnancy | 33.15 | 10.13 | 9 | 101618 | 27128 | 46557307 |
Sinoatrial block | 32.60 | 10.13 | 21 | 101606 | 797 | 46583638 |
Acute motor-sensory axonal neuropathy | 32.47 | 10.13 | 16 | 101611 | 358 | 46584077 |
Pleural effusion | 32.43 | 10.13 | 299 | 101328 | 82653 | 46501782 |
Insomnia | 32.36 | 10.13 | 218 | 101409 | 164706 | 46419729 |
Migraine | 32.07 | 10.13 | 65 | 101562 | 69961 | 46514474 |
Loss of personal independence in daily activities | 31.73 | 10.13 | 47 | 101580 | 57136 | 46527299 |
Synovitis | 31.24 | 10.13 | 53 | 101574 | 61022 | 46523413 |
HLA-B*5801 assay positive | 30.79 | 10.13 | 6 | 101621 | 0 | 46584435 |
Differentiation syndrome | 30.54 | 10.13 | 21 | 101606 | 890 | 46583545 |
Product dose omission issue | 30.50 | 10.13 | 228 | 101399 | 168292 | 46416143 |
Sight disability | 30.23 | 10.13 | 11 | 101616 | 111 | 46584324 |
Thermohypoaesthesia | 30.14 | 10.13 | 11 | 101616 | 112 | 46584323 |
Respiratory failure | 29.94 | 10.13 | 327 | 101300 | 94489 | 46489946 |
Intentional self-injury | 29.55 | 10.13 | 8 | 101619 | 24158 | 46560277 |
Foetal exposure during pregnancy | 29.51 | 10.13 | 15 | 101612 | 30732 | 46553703 |
Feeling abnormal | 29.44 | 10.13 | 156 | 101471 | 124904 | 46459531 |
Throat irritation | 29.43 | 10.13 | 13 | 101614 | 28888 | 46555547 |
Product quality issue | 29.17 | 10.13 | 21 | 101606 | 35627 | 46548808 |
Device dislocation | 29.06 | 10.13 | 6 | 101621 | 21796 | 46562639 |
Human herpesvirus 6 infection | 29.01 | 10.13 | 31 | 101596 | 2408 | 46582027 |
Hypersensitivity | 28.84 | 10.13 | 200 | 101427 | 150121 | 46434314 |
White blood cell count decreased | 28.80 | 10.13 | 372 | 101255 | 111859 | 46472576 |
Azotaemia | 28.55 | 10.13 | 41 | 101586 | 4310 | 46580125 |
Rectal haemorrhage | 28.45 | 10.13 | 161 | 101466 | 38094 | 46546341 |
Lip erosion | 28.17 | 10.13 | 19 | 101608 | 780 | 46583655 |
Right ventricular failure | 28.10 | 10.13 | 88 | 101539 | 16005 | 46568430 |
Fibromyalgia | 27.90 | 10.13 | 23 | 101604 | 36440 | 46547995 |
Psoriatic arthropathy | 27.77 | 10.13 | 23 | 101604 | 36356 | 46548079 |
Rhabdomyolysis | 27.70 | 10.13 | 171 | 101456 | 41738 | 46542697 |
Diarrhoea | 27.46 | 10.13 | 1484 | 100143 | 558118 | 46026317 |
Sleep disorder | 27.41 | 10.13 | 37 | 101590 | 46758 | 46537677 |
Metabolic acidosis | 27.39 | 10.13 | 161 | 101466 | 38619 | 46545816 |
Glomerular filtration rate decreased | 27.29 | 10.13 | 71 | 101556 | 11623 | 46572812 |
Electrolyte imbalance | 27.19 | 10.13 | 91 | 101536 | 17135 | 46567300 |
Rash erythematous | 27.17 | 10.13 | 147 | 101480 | 34203 | 46550232 |
Hypercalcaemia | 27.09 | 10.13 | 104 | 101523 | 20942 | 46563493 |
Dermatitis exfoliative generalised | 26.88 | 10.13 | 33 | 101594 | 2980 | 46581455 |
Anaemia macrocytic | 26.87 | 10.13 | 31 | 101596 | 2622 | 46581813 |
Infusion related reaction | 26.85 | 10.13 | 121 | 101506 | 101087 | 46483348 |
Enanthema | 26.57 | 10.13 | 15 | 101612 | 446 | 46583989 |
Agranulocytosis | 26.43 | 10.13 | 107 | 101520 | 22078 | 46562357 |
Subdural haematoma | 26.42 | 10.13 | 75 | 101552 | 12922 | 46571513 |
Klebsiella infection | 26.40 | 10.13 | 50 | 101577 | 6612 | 46577823 |
Blood creatine phosphokinase increased | 26.39 | 10.13 | 125 | 101502 | 27599 | 46556836 |
Alanine aminotransferase increased | 26.09 | 10.13 | 301 | 101326 | 88150 | 46496285 |
Pemphigoid | 25.44 | 10.13 | 45 | 101582 | 5646 | 46578789 |
Wrong technique in product usage process | 25.36 | 10.13 | 50 | 101577 | 54372 | 46530063 |
Chemical burn of oral cavity | 25.26 | 10.13 | 9 | 101618 | 85 | 46584350 |
Anuria | 25.25 | 10.13 | 68 | 101559 | 11363 | 46573072 |
Oral mucosa erosion | 25.01 | 10.13 | 20 | 101607 | 1070 | 46583365 |
Discomfort | 24.33 | 10.13 | 40 | 101587 | 46630 | 46537805 |
Septic shock | 24.33 | 10.13 | 212 | 101415 | 57681 | 46526754 |
Hyperpyrexia | 24.20 | 10.13 | 30 | 101597 | 2736 | 46581699 |
Erythema multiforme | 23.77 | 10.13 | 60 | 101567 | 9644 | 46574791 |
Petechiae | 23.73 | 10.13 | 71 | 101556 | 12599 | 46571836 |
Disseminated intravascular coagulation | 23.72 | 10.13 | 93 | 101534 | 18912 | 46565523 |
Haemodialysis | 23.64 | 10.13 | 58 | 101569 | 9159 | 46575276 |
Coagulation test abnormal | 23.63 | 10.13 | 16 | 101611 | 661 | 46583774 |
Leukopenia | 23.59 | 10.13 | 240 | 101387 | 68103 | 46516332 |
Gastrointestinal disorder | 23.46 | 10.13 | 60 | 101567 | 59516 | 46524919 |
Asthma | 23.36 | 10.13 | 111 | 101516 | 91431 | 46493004 |
Intentional product use issue | 23.31 | 10.13 | 50 | 101577 | 52730 | 46531705 |
Paraesthesia | 23.14 | 10.13 | 155 | 101472 | 117282 | 46467153 |
Abdominal pain upper | 22.90 | 10.13 | 204 | 101423 | 145101 | 46439334 |
Dermatitis bullous | 22.77 | 10.13 | 51 | 101576 | 7592 | 46576843 |
Multiple sclerosis | 22.47 | 10.13 | 13 | 101614 | 24778 | 46559657 |
Platelet disorder | 22.47 | 10.13 | 22 | 101605 | 1541 | 46582894 |
Cerebellar stroke | 22.42 | 10.13 | 10 | 101617 | 177 | 46584258 |
Oedema | 22.42 | 10.13 | 234 | 101393 | 66837 | 46517598 |
Accidental exposure to product | 22.24 | 10.13 | 9 | 101618 | 21072 | 46563363 |
Papillary muscle rupture | 22.21 | 10.13 | 5 | 101622 | 5 | 46584430 |
Dyspnoea | 22.13 | 10.13 | 1351 | 100276 | 514197 | 46070238 |
Hypovolaemic shock | 21.91 | 10.13 | 40 | 101587 | 5143 | 46579292 |
Injection site rash | 21.82 | 10.13 | 4 | 101623 | 15809 | 46568626 |
Necrotising ulcerative gingivostomatitis | 21.81 | 10.13 | 6 | 101621 | 21 | 46584414 |
Eosinopenia | 21.73 | 10.13 | 5 | 101622 | 6 | 46584429 |
Mucosal ulceration | 21.68 | 10.13 | 17 | 101610 | 884 | 46583551 |
No adverse event | 21.15 | 10.13 | 26 | 101601 | 34205 | 46550230 |
Osteoarthritis | 21.09 | 10.13 | 67 | 101560 | 61958 | 46522477 |
Hypoaesthesia | 20.94 | 10.13 | 162 | 101465 | 118707 | 46465728 |
Abdominal wall wound | 20.78 | 10.13 | 7 | 101620 | 55 | 46584380 |
Syncope | 20.75 | 10.13 | 332 | 101295 | 104471 | 46479964 |
Vessel puncture site haemorrhage | 20.67 | 10.13 | 8 | 101619 | 97 | 46584338 |
Hyperglycaemia | 20.66 | 10.13 | 139 | 101488 | 34932 | 46549503 |
Hyperphosphataemia | 20.64 | 10.13 | 22 | 101605 | 1704 | 46582731 |
Administration site discomfort | 20.38 | 10.13 | 8 | 101619 | 101 | 46584334 |
Injection site mass | 20.33 | 10.13 | 4 | 101623 | 15036 | 46569399 |
Hip arthroplasty | 20.33 | 10.13 | 7 | 101620 | 18105 | 46566330 |
Drug withdrawal syndrome | 20.06 | 10.13 | 18 | 101609 | 27366 | 46557069 |
Injection site haemorrhage | 20.03 | 10.13 | 10 | 101617 | 20699 | 46563736 |
Blood pressure fluctuation | 20.03 | 10.13 | 22 | 101605 | 30426 | 46554009 |
Pericardial effusion | 19.99 | 10.13 | 109 | 101518 | 25434 | 46559001 |
Blood pressure increased | 19.88 | 10.13 | 178 | 101449 | 126488 | 46457947 |
Arrhythmia | 19.87 | 10.13 | 137 | 101490 | 34704 | 46549731 |
Cardiac failure acute | 19.84 | 10.13 | 50 | 101577 | 8028 | 46576407 |
Conjunctivitis | 19.67 | 10.13 | 76 | 101551 | 15348 | 46569087 |
Renal disorder | 19.63 | 10.13 | 112 | 101515 | 26574 | 46557861 |
Lip oedema | 19.63 | 10.13 | 30 | 101597 | 3334 | 46581101 |
Swelling | 19.53 | 10.13 | 175 | 101452 | 124336 | 46460099 |
Hypoglycaemic coma | 19.51 | 10.13 | 26 | 101601 | 2548 | 46581887 |
Amaurosis | 19.51 | 10.13 | 13 | 101614 | 523 | 46583912 |
Stress | 19.48 | 10.13 | 53 | 101574 | 51498 | 46532937 |
Back pain | 19.37 | 10.13 | 331 | 101296 | 209708 | 46374727 |
Transfusion | 19.23 | 10.13 | 68 | 101559 | 13163 | 46571272 |
Hepatitis | 19.17 | 10.13 | 128 | 101499 | 32087 | 46552348 |
Mandibular mass | 19.09 | 10.13 | 9 | 101618 | 182 | 46584253 |
Mucosal erosion | 18.84 | 10.13 | 19 | 101608 | 1379 | 46583056 |
Blood potassium increased | 18.78 | 10.13 | 80 | 101547 | 16887 | 46567548 |
Acute respiratory failure | 18.70 | 10.13 | 118 | 101509 | 29020 | 46555415 |
Tonsillar haemorrhage | 18.65 | 10.13 | 9 | 101618 | 192 | 46584243 |
Hepatocellular injury | 18.60 | 10.13 | 119 | 101508 | 29403 | 46555032 |
Myeloblast percentage decreased | 18.53 | 10.13 | 6 | 101621 | 41 | 46584394 |
Heart rate increased | 18.32 | 10.13 | 92 | 101535 | 74699 | 46509736 |
Pseudomonal bacteraemia | 18.24 | 10.13 | 18 | 101609 | 1273 | 46583162 |
Terminal ileitis | 18.07 | 10.13 | 8 | 101619 | 139 | 46584296 |
Drug eruption | 18.04 | 10.13 | 93 | 101534 | 21236 | 46563199 |
Diverticulum oesophageal | 18.02 | 10.13 | 8 | 101619 | 140 | 46584295 |
Fluid overload | 18.01 | 10.13 | 111 | 101516 | 27074 | 46557361 |
Influenza | 17.99 | 10.13 | 117 | 101510 | 89153 | 46495282 |
Ecchymosis | 17.70 | 10.13 | 57 | 101570 | 10519 | 46573916 |
Diabetes mellitus inadequate control | 17.59 | 10.13 | 66 | 101561 | 13148 | 46571287 |
Musculoskeletal stiffness | 17.51 | 10.13 | 133 | 101494 | 97860 | 46486575 |
Atrioventricular block complete | 17.49 | 10.13 | 46 | 101581 | 7581 | 46576854 |
Tachyarrhythmia | 17.41 | 10.13 | 34 | 101593 | 4598 | 46579837 |
Blood alkaline phosphatase increased | 17.14 | 10.13 | 146 | 101481 | 39463 | 46544972 |
Renal infarct | 17.14 | 10.13 | 17 | 101610 | 1210 | 46583225 |
Therapeutic drug monitoring analysis incorrectly performed | 17.10 | 10.13 | 8 | 101619 | 159 | 46584276 |
Cerebral haemorrhage | 17.04 | 10.13 | 113 | 101514 | 28258 | 46556177 |
Glomerulonephritis | 16.98 | 10.13 | 19 | 101608 | 1554 | 46582881 |
Urine output decreased | 16.96 | 10.13 | 58 | 101569 | 11039 | 46573396 |
Hypocalcaemia | 16.89 | 10.13 | 108 | 101519 | 26677 | 46557758 |
Red blood cell sedimentation rate increased | 16.82 | 10.13 | 15 | 101612 | 22874 | 46561561 |
Arthritis | 16.79 | 10.13 | 99 | 101528 | 77217 | 46507218 |
Neutrophil count decreased | 16.70 | 10.13 | 156 | 101471 | 43270 | 46541165 |
Cholestasis | 16.69 | 10.13 | 108 | 101519 | 26785 | 46557650 |
Poisoning | 16.43 | 10.13 | 5 | 101622 | 13989 | 46570446 |
Anger | 16.35 | 10.13 | 3 | 101624 | 11849 | 46572586 |
Pain in extremity | 16.16 | 10.13 | 434 | 101193 | 258246 | 46326189 |
B-cell unclassifiable lymphoma high grade | 16.15 | 10.13 | 4 | 101623 | 8 | 46584427 |
Streptococcal sepsis | 16.10 | 10.13 | 19 | 101608 | 1646 | 46582789 |
Multimorbidity | 16.10 | 10.13 | 13 | 101614 | 705 | 46583730 |
Mantle cell lymphoma | 16.08 | 10.13 | 12 | 101615 | 579 | 46583856 |
Metastases to bone | 16.07 | 10.13 | 9 | 101618 | 17467 | 46566968 |
Lymphocytosis | 16.07 | 10.13 | 22 | 101605 | 2212 | 46582223 |
Pericarditis | 16.06 | 10.13 | 17 | 101610 | 23910 | 46560525 |
Aplasia pure red cell | 16.05 | 10.13 | 32 | 101595 | 4393 | 46580042 |
Acute generalised exanthematous pustulosis | 16.03 | 10.13 | 51 | 101576 | 9354 | 46575081 |
Pulmonary oedema | 16.01 | 10.13 | 176 | 101451 | 50929 | 46533506 |
Cardiac failure chronic | 15.93 | 10.13 | 28 | 101599 | 3496 | 46580939 |
Hypersensitivity vasculitis | 15.89 | 10.13 | 31 | 101596 | 4190 | 46580245 |
Influenza like illness | 15.76 | 10.13 | 68 | 101559 | 57502 | 46526933 |
Medication error | 15.58 | 10.13 | 118 | 101509 | 30793 | 46553642 |
Nephrogenic anaemia | 15.55 | 10.13 | 20 | 101607 | 1893 | 46582542 |
Performance enhancing product use | 15.54 | 10.13 | 4 | 101623 | 10 | 46584425 |
Limb discomfort | 15.49 | 10.13 | 16 | 101611 | 22760 | 46561675 |
Hyperbilirubinaemia | 15.47 | 10.13 | 54 | 101573 | 10384 | 46574051 |
Eye pain | 15.46 | 10.13 | 23 | 101604 | 27917 | 46556518 |
Gouty arthritis | 15.40 | 10.13 | 11 | 101616 | 496 | 46583939 |
Emphysematous cystitis | 15.39 | 10.13 | 7 | 101620 | 130 | 46584305 |
Anti-neutrophil cytoplasmic antibody positive vasculitis | 15.37 | 10.13 | 20 | 101607 | 1915 | 46582520 |
Generalised tonic-clonic seizure | 15.33 | 10.13 | 22 | 101605 | 27100 | 46557335 |
Dizziness | 15.32 | 10.13 | 596 | 101031 | 339818 | 46244617 |
Packed red blood cell transfusion | 15.11 | 10.13 | 21 | 101606 | 2142 | 46582293 |
Hepatic enzyme increased | 15.09 | 10.13 | 110 | 101517 | 81677 | 46502758 |
Product monitoring error | 15.00 | 10.13 | 20 | 101607 | 1961 | 46582474 |
Respiratory arrest | 14.96 | 10.13 | 32 | 101595 | 33784 | 46550651 |
Hepatic function abnormal | 14.95 | 10.13 | 127 | 101500 | 34294 | 46550141 |
Neuroleptic malignant syndrome | 14.95 | 10.13 | 3 | 101624 | 11119 | 46573316 |
Gravitational oedema | 14.92 | 10.13 | 15 | 101612 | 1085 | 46583350 |
Paraneoplastic syndrome | 14.88 | 10.13 | 11 | 101616 | 523 | 46583912 |
Bone marrow failure | 14.81 | 10.13 | 113 | 101514 | 29556 | 46554879 |
Uveitic glaucoma | 14.77 | 10.13 | 4 | 101623 | 13 | 46584422 |
Dyspnoea exertional | 14.76 | 10.13 | 171 | 101456 | 50118 | 46534317 |
Ear infection | 14.73 | 10.13 | 17 | 101610 | 22996 | 46561439 |
Nodal arrhythmia | 14.72 | 10.13 | 16 | 101611 | 1267 | 46583168 |
Knee arthroplasty | 14.59 | 10.13 | 18 | 101609 | 23647 | 46560788 |
Leukocytosis | 14.54 | 10.13 | 94 | 101533 | 23304 | 46561131 |
Venoocclusive liver disease | 14.54 | 10.13 | 30 | 101597 | 4221 | 46580214 |
Autoimmune haemolytic anaemia | 14.51 | 10.13 | 30 | 101597 | 4228 | 46580207 |
Chronic myeloid leukaemia | 14.46 | 10.13 | 22 | 101605 | 2436 | 46581999 |
Staphylococcal scalded skin syndrome | 14.44 | 10.13 | 7 | 101620 | 151 | 46584284 |
Burning sensation | 14.39 | 10.13 | 49 | 101578 | 44362 | 46540073 |
Haemoperitoneum | 14.30 | 10.13 | 22 | 101605 | 2460 | 46581975 |
Diabetic hyperosmolar coma | 14.21 | 10.13 | 10 | 101617 | 440 | 46583995 |
Erosive oesophagitis | 14.19 | 10.13 | 18 | 101609 | 1680 | 46582755 |
Cholestatic liver injury | 14.17 | 10.13 | 20 | 101607 | 2070 | 46582365 |
Complication associated with device | 14.13 | 10.13 | 8 | 101619 | 15433 | 46569002 |
Orthopnoea | 14.03 | 10.13 | 36 | 101591 | 5844 | 46578591 |
Upper respiratory tract infection | 14.00 | 10.13 | 81 | 101546 | 63475 | 46520960 |
Parakeratosis | 13.99 | 10.13 | 7 | 101620 | 162 | 46584273 |
Ill-defined disorder | 13.97 | 10.13 | 23 | 101604 | 26804 | 46557631 |
Blood uric acid abnormal | 13.96 | 10.13 | 5 | 101622 | 48 | 46584387 |
Duodenal stenosis | 13.88 | 10.13 | 11 | 101616 | 581 | 46583854 |
Hepatic failure | 13.84 | 10.13 | 122 | 101505 | 33294 | 46551141 |
Cholecystitis chronic | 13.77 | 10.13 | 3 | 101624 | 10496 | 46573939 |
Hypocoagulable state | 13.69 | 10.13 | 14 | 101613 | 1033 | 46583402 |
Full blood count decreased | 13.66 | 10.13 | 89 | 101538 | 22122 | 46562313 |
Acute myeloid leukaemia recurrent | 13.62 | 10.13 | 16 | 101611 | 1380 | 46583055 |
Overdose | 13.61 | 10.13 | 149 | 101478 | 101830 | 46482605 |
Lip haemorrhage | 13.60 | 10.13 | 10 | 101617 | 472 | 46583963 |
Drug dependence | 13.51 | 10.13 | 14 | 101613 | 19887 | 46564548 |
Haematocrit decreased | 13.51 | 10.13 | 126 | 101501 | 34931 | 46549504 |
Hepatotoxicity | 13.48 | 10.13 | 97 | 101530 | 24912 | 46559523 |
Dermatitis | 13.48 | 10.13 | 64 | 101563 | 14144 | 46570291 |
Live birth | 13.45 | 10.13 | 3 | 101624 | 10327 | 46574108 |
Drug-induced liver injury | 13.45 | 10.13 | 98 | 101529 | 25270 | 46559165 |
Mucocutaneous haemorrhage | 13.36 | 10.13 | 5 | 101622 | 55 | 46584380 |
Diabetic ketoacidosis | 13.30 | 10.13 | 12 | 101615 | 18198 | 46566237 |
Serum ferritin increased | 13.29 | 10.13 | 33 | 101594 | 5250 | 46579185 |
HLA marker study positive | 13.29 | 10.13 | 7 | 101620 | 181 | 46584254 |
Cardiomegaly | 13.27 | 10.13 | 74 | 101553 | 17408 | 46567027 |
Prerenal failure | 13.24 | 10.13 | 16 | 101611 | 1421 | 46583014 |
Blood bilirubin increased | 13.24 | 10.13 | 123 | 101504 | 34061 | 46550374 |
Neutropenic colitis | 13.16 | 10.13 | 20 | 101607 | 2212 | 46582223 |
Irritability | 13.14 | 10.13 | 27 | 101600 | 28919 | 46555516 |
Pulmonary arterial hypertension | 13.08 | 10.13 | 99 | 101528 | 25829 | 46558606 |
Adult failure to thrive | 13.07 | 10.13 | 6 | 101621 | 114 | 46584321 |
Somnolence | 13.05 | 10.13 | 251 | 101376 | 156270 | 46428165 |
Foot fracture | 13.04 | 10.13 | 14 | 101613 | 19568 | 46564867 |
Adverse event | 13.02 | 10.13 | 35 | 101592 | 34149 | 46550286 |
Mixed liver injury | 12.96 | 10.13 | 24 | 101603 | 3119 | 46581316 |
Vision blurred | 12.95 | 10.13 | 111 | 101516 | 79597 | 46504838 |
Aspartate aminotransferase increased | 12.93 | 10.13 | 242 | 101385 | 78458 | 46505977 |
Panic attack | 12.90 | 10.13 | 15 | 101612 | 20227 | 46564208 |
Lymphocytic infiltration | 12.83 | 10.13 | 12 | 101615 | 794 | 46583641 |
Upper gastrointestinal haemorrhage | 12.81 | 10.13 | 71 | 101556 | 16667 | 46567768 |
Oral contusion | 12.75 | 10.13 | 5 | 101622 | 63 | 46584372 |
Insulin-requiring type 2 diabetes mellitus | 12.75 | 10.13 | 5 | 101622 | 63 | 46584372 |
Chronic myeloid leukaemia recurrent | 12.68 | 10.13 | 7 | 101620 | 199 | 46584236 |
Chronic lymphocytic leukaemia recurrent | 12.68 | 10.13 | 7 | 101620 | 199 | 46584236 |
Pruritus | 12.67 | 10.13 | 647 | 100980 | 241705 | 46342730 |
Electrocardiogram QT shortened | 12.61 | 10.13 | 6 | 101621 | 124 | 46584311 |
Shock | 12.52 | 10.13 | 86 | 101541 | 21759 | 46562676 |
Nasal mucosal erosion | 12.47 | 10.13 | 5 | 101622 | 67 | 46584368 |
Trichiasis | 12.40 | 10.13 | 5 | 101622 | 68 | 46584367 |
Eosinophilic pustular folliculitis | 12.40 | 10.13 | 4 | 101623 | 27 | 46584408 |
Sternal fracture | 12.31 | 10.13 | 16 | 101611 | 1530 | 46582905 |
Blood phosphorus increased | 12.23 | 10.13 | 22 | 101605 | 2797 | 46581638 |
Venoocclusive disease | 12.21 | 10.13 | 18 | 101609 | 1938 | 46582497 |
Deficiency anaemia | 12.11 | 10.13 | 3 | 101624 | 6 | 46584429 |
Fixed eruption | 12.11 | 10.13 | 12 | 101615 | 853 | 46583582 |
Gastritis erosive | 12.07 | 10.13 | 32 | 101595 | 5298 | 46579137 |
Injury | 12.05 | 10.13 | 52 | 101575 | 43975 | 46540460 |
Withdrawal syndrome | 12.04 | 10.13 | 13 | 101614 | 18121 | 46566314 |
Drug resistance | 12.04 | 10.13 | 12 | 101615 | 17356 | 46567079 |
Eye oedema | 12.00 | 10.13 | 15 | 101612 | 1380 | 46583055 |
Ileal ulcer | 11.99 | 10.13 | 9 | 101618 | 438 | 46583997 |
Conjunctival hyperaemia | 11.98 | 10.13 | 18 | 101609 | 1971 | 46582464 |
Spontaneous haematoma | 11.98 | 10.13 | 11 | 101616 | 711 | 46583724 |
Retroperitoneal haematoma | 11.96 | 10.13 | 21 | 101606 | 2619 | 46581816 |
Weight decreased | 11.83 | 10.13 | 359 | 101268 | 210490 | 46373945 |
Procedural pain | 11.82 | 10.13 | 7 | 101620 | 13172 | 46571263 |
Extensor plantar response | 11.78 | 10.13 | 14 | 101613 | 1222 | 46583213 |
Musculoskeletal disorder | 11.65 | 10.13 | 10 | 101617 | 15535 | 46568900 |
Chest discomfort | 11.61 | 10.13 | 133 | 101494 | 90136 | 46494299 |
Proteus test positive | 11.61 | 10.13 | 6 | 101621 | 149 | 46584286 |
Blood electrolytes increased | 11.60 | 10.13 | 4 | 101623 | 34 | 46584401 |
Multiple drug therapy | 11.59 | 10.13 | 12 | 101615 | 899 | 46583536 |
Strangury | 11.52 | 10.13 | 3 | 101624 | 8 | 46584427 |
Disturbance in attention | 11.51 | 10.13 | 33 | 101594 | 31527 | 46552908 |
Device issue | 11.50 | 10.13 | 16 | 101611 | 19964 | 46564471 |
Abnormal dreams | 11.49 | 10.13 | 4 | 101623 | 10275 | 46574160 |
Prurigo | 11.49 | 10.13 | 12 | 101615 | 908 | 46583527 |
Aggression | 11.39 | 10.13 | 20 | 101607 | 22724 | 46561711 |
Surgery | 11.32 | 10.13 | 29 | 101598 | 28756 | 46555679 |
Depressed mood | 11.32 | 10.13 | 36 | 101591 | 33283 | 46551152 |
Weight increased | 11.32 | 10.13 | 272 | 101355 | 164201 | 46420234 |
Spigelian hernia | 11.30 | 10.13 | 4 | 101623 | 37 | 46584398 |
Epidermolysis | 11.30 | 10.13 | 7 | 101620 | 248 | 46584187 |
Pulmonary hypertension | 11.29 | 10.13 | 124 | 101503 | 35869 | 46548566 |
Nephropathy | 11.28 | 10.13 | 30 | 101597 | 4975 | 46579460 |
Calciphylaxis | 11.27 | 10.13 | 20 | 101607 | 2515 | 46581920 |
Therapeutic drug monitoring analysis not performed | 11.26 | 10.13 | 9 | 101618 | 481 | 46583954 |
Psychotic disorder | 11.23 | 10.13 | 20 | 101607 | 22601 | 46561834 |
Visual impairment | 11.22 | 10.13 | 92 | 101535 | 66597 | 46517838 |
Cardiac failure congestive | 11.15 | 10.13 | 270 | 101357 | 91480 | 46492955 |
Respiratory tract congestion | 11.14 | 10.13 | 7 | 101620 | 12757 | 46571678 |
Eosinophilic myocarditis | 11.11 | 10.13 | 8 | 101619 | 365 | 46584070 |
Renal hypertension | 11.11 | 10.13 | 4 | 101623 | 39 | 46584396 |
Halo vision | 11.06 | 10.13 | 8 | 101619 | 368 | 46584067 |
Optic ischaemic neuropathy | 11.03 | 10.13 | 12 | 101615 | 951 | 46583484 |
Neutropenic infection | 11.03 | 10.13 | 13 | 101614 | 1125 | 46583310 |
Cardiac murmur functional | 11.02 | 10.13 | 4 | 101623 | 40 | 46584395 |
Urosepsis | 11.01 | 10.13 | 64 | 101563 | 15289 | 46569146 |
Rheumatoid nodule | 11 | 10.13 | 3 | 101624 | 9017 | 46575418 |
Acid base balance abnormal | 10.93 | 10.13 | 7 | 101620 | 263 | 46584172 |
Platelet dysfunction | 10.89 | 10.13 | 5 | 101622 | 95 | 46584340 |
Transaminases increased | 10.81 | 10.13 | 100 | 101527 | 27661 | 46556774 |
Meibomian gland dysfunction | 10.75 | 10.13 | 5 | 101622 | 98 | 46584337 |
Bone marrow transplant | 10.71 | 10.13 | 10 | 101617 | 660 | 46583775 |
Neuromyelitis optica spectrum disorder | 10.70 | 10.13 | 11 | 101616 | 817 | 46583618 |
Rash pruritic | 10.68 | 10.13 | 145 | 101482 | 44070 | 46540365 |
Serotonin syndrome | 10.65 | 10.13 | 23 | 101604 | 24197 | 46560238 |
Blood pressure systolic increased | 10.57 | 10.13 | 30 | 101597 | 28757 | 46555678 |
Emotional distress | 10.56 | 10.13 | 33 | 101594 | 30674 | 46553761 |
Ear pain | 10.55 | 10.13 | 20 | 101607 | 22072 | 46562363 |
Presyncope | 10.50 | 10.13 | 90 | 101537 | 24364 | 46560071 |
Pseudomonal sepsis | 10.50 | 10.13 | 17 | 101610 | 1985 | 46582450 |
Bradyarrhythmia | 10.47 | 10.13 | 17 | 101610 | 1989 | 46582446 |
Throat tightness | 10.47 | 10.13 | 18 | 101609 | 20621 | 46563814 |
Device breakage | 10.45 | 10.13 | 4 | 101623 | 9688 | 46574747 |
Acne | 10.45 | 10.13 | 17 | 101610 | 19902 | 46564533 |
Leukostasis syndrome | 10.37 | 10.13 | 4 | 101623 | 48 | 46584387 |
Cough | 10.37 | 10.13 | 403 | 101224 | 229846 | 46354589 |
Rhinorrhoea | 10.37 | 10.13 | 61 | 101566 | 47604 | 46536831 |
Tooth infection | 10.36 | 10.13 | 7 | 101620 | 12279 | 46572156 |
Left ventricular failure | 10.34 | 10.13 | 29 | 101598 | 4961 | 46579474 |
Maternal condition affecting foetus | 10.32 | 10.13 | 6 | 101621 | 189 | 46584246 |
Endocarditis | 10.26 | 10.13 | 29 | 101598 | 4983 | 46579452 |
Aortic valve sclerosis | 10.26 | 10.13 | 12 | 101615 | 1030 | 46583405 |
Hyperviscosity syndrome | 10.23 | 10.13 | 6 | 101621 | 192 | 46584243 |
Hypozincaemia | 10.22 | 10.13 | 3 | 101624 | 14 | 46584421 |
Crying | 10.22 | 10.13 | 19 | 101608 | 21122 | 46563313 |
Head banging | 10.20 | 10.13 | 8 | 101619 | 416 | 46584019 |
Schizophrenia | 10.17 | 10.13 | 3 | 101624 | 8565 | 46575870 |
Muscle necrosis | 10.16 | 10.13 | 9 | 101618 | 555 | 46583880 |
Joint stiffness | 10.14 | 10.13 | 28 | 101599 | 27080 | 46557355 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug reaction with eosinophilia and systemic symptoms | 1098.94 | 10.22 | 1076 | 174320 | 27412 | 29749670 |
Gout | 380.62 | 10.22 | 488 | 174908 | 16827 | 29760255 |
Acute kidney injury | 366.13 | 10.22 | 2796 | 172600 | 271046 | 29506036 |
Drug ineffective | 358.29 | 10.22 | 929 | 174467 | 339458 | 29437624 |
Drug abuse | 317.98 | 10.22 | 50 | 175346 | 82022 | 29695060 |
Toxicity to various agents | 284.22 | 10.22 | 373 | 175023 | 176810 | 29600272 |
Tumour lysis syndrome | 252.04 | 10.22 | 343 | 175053 | 12542 | 29764540 |
Completed suicide | 204.94 | 10.22 | 169 | 175227 | 99323 | 29677759 |
Hyperkalaemia | 163.13 | 10.22 | 792 | 174604 | 65218 | 29711864 |
Stevens-Johnson syndrome | 156.65 | 10.22 | 329 | 175067 | 17227 | 29759855 |
Renal failure | 152.42 | 10.22 | 1282 | 174114 | 127684 | 29649398 |
Off label use | 144.72 | 10.22 | 862 | 174534 | 248428 | 29528654 |
Foetal exposure during pregnancy | 141.51 | 10.22 | 23 | 175373 | 36848 | 29740234 |
Anaemia | 138.23 | 10.22 | 1840 | 173556 | 206152 | 29570930 |
Hyperuricaemia | 122.69 | 10.22 | 182 | 175214 | 7212 | 29769870 |
Eosinophilia | 122.25 | 10.22 | 345 | 175051 | 21815 | 29755267 |
Febrile neutropenia | 116.26 | 10.22 | 1042 | 174354 | 105651 | 29671431 |
Cardiac failure | 111.37 | 10.22 | 853 | 174543 | 82565 | 29694517 |
Toxic epidermal necrolysis | 100.61 | 10.22 | 281 | 175115 | 17659 | 29759423 |
Intentional overdose | 87.15 | 10.22 | 69 | 175327 | 41412 | 29735670 |
Blood creatinine increased | 83.47 | 10.22 | 860 | 174536 | 90515 | 29686567 |
Headache | 82.65 | 10.22 | 677 | 174719 | 181629 | 29595453 |
Drug dependence | 77.97 | 10.22 | 15 | 175381 | 21280 | 29755802 |
General physical health deterioration | 77.23 | 10.22 | 910 | 174486 | 99034 | 29678048 |
Cytokine release syndrome | 75.97 | 10.22 | 175 | 175221 | 9758 | 29767324 |
Product use in unapproved indication | 75.59 | 10.22 | 203 | 175193 | 73490 | 29703592 |
Chronic kidney disease | 73.51 | 10.22 | 425 | 174971 | 37413 | 29739669 |
Treatment failure | 69.98 | 10.22 | 60 | 175336 | 34619 | 29742463 |
Suicide attempt | 69.87 | 10.22 | 67 | 175329 | 36630 | 29740452 |
Blood uric acid increased | 69.72 | 10.22 | 126 | 175270 | 5897 | 29771185 |
Chronic lymphocytic leukaemia | 68.44 | 10.22 | 108 | 175288 | 4520 | 29772562 |
Death | 67.89 | 10.22 | 1585 | 173811 | 355698 | 29421384 |
Renal impairment | 66.57 | 10.22 | 770 | 174626 | 83414 | 29693668 |
Rheumatoid arthritis | 65.58 | 10.22 | 87 | 175309 | 41110 | 29735972 |
Overdose | 64.67 | 10.22 | 264 | 175132 | 84073 | 29693009 |
Seizure | 63.76 | 10.22 | 328 | 175068 | 98147 | 29678935 |
Depression | 62.72 | 10.22 | 294 | 175102 | 90143 | 29686939 |
Oedema peripheral | 61.89 | 10.22 | 916 | 174480 | 104916 | 29672166 |
Dermatitis exfoliative generalised | 61.29 | 10.22 | 79 | 175317 | 2736 | 29774346 |
Thrombocytopenia | 60.58 | 10.22 | 1133 | 174263 | 135911 | 29641171 |
Toxic skin eruption | 60.25 | 10.22 | 171 | 175225 | 10844 | 29766238 |
Drug withdrawal syndrome | 59.13 | 10.22 | 21 | 175375 | 19788 | 29757294 |
Anxiety | 58.94 | 10.22 | 298 | 175098 | 89573 | 29687509 |
Rash maculo-papular | 58.48 | 10.22 | 299 | 175097 | 25119 | 29751963 |
Dermatitis exfoliative | 55.52 | 10.22 | 130 | 175266 | 7326 | 29769756 |
Therapeutic product effect incomplete | 55.34 | 10.22 | 70 | 175326 | 33764 | 29743318 |
Suicidal ideation | 54.74 | 10.22 | 79 | 175317 | 36035 | 29741047 |
Premature baby | 54.65 | 10.22 | 15 | 175381 | 16676 | 29760406 |
Aggression | 53.74 | 10.22 | 83 | 175313 | 36824 | 29740258 |
Injection site pain | 50.32 | 10.22 | 62 | 175334 | 30248 | 29746834 |
Pain | 48.55 | 10.22 | 715 | 174681 | 171926 | 29605156 |
Drug resistance | 48.25 | 10.22 | 29 | 175367 | 20104 | 29756978 |
Product dose omission issue | 47.76 | 10.22 | 327 | 175069 | 91304 | 29685778 |
Blood lactate dehydrogenase increased | 45.76 | 10.22 | 240 | 175156 | 20361 | 29756721 |
Melaena | 45.08 | 10.22 | 335 | 175061 | 32102 | 29744980 |
Insomnia | 44.81 | 10.22 | 341 | 175055 | 92995 | 29684087 |
Gouty arthritis | 44.68 | 10.22 | 42 | 175354 | 1013 | 29776069 |
Epistaxis | 44.29 | 10.22 | 490 | 174906 | 52491 | 29724591 |
Atrial fibrillation | 44.03 | 10.22 | 883 | 174513 | 107241 | 29669841 |
Syncope | 43.94 | 10.22 | 720 | 174676 | 84183 | 29692899 |
Face oedema | 43.71 | 10.22 | 156 | 175240 | 11178 | 29765904 |
Intentional product misuse | 43.18 | 10.22 | 86 | 175310 | 34581 | 29742501 |
Pyrexia | 42.90 | 10.22 | 2121 | 173275 | 292368 | 29484714 |
Platelet count decreased | 42.31 | 10.22 | 864 | 174532 | 105265 | 29671817 |
Drug intolerance | 41.87 | 10.22 | 131 | 175265 | 45160 | 29731922 |
Hypotension | 41.26 | 10.22 | 1498 | 173898 | 199067 | 29578015 |
Blood urea increased | 40.76 | 10.22 | 319 | 175077 | 31062 | 29746020 |
Respiratory arrest | 40.52 | 10.22 | 68 | 175328 | 29190 | 29747892 |
Cardio-respiratory arrest | 40.47 | 10.22 | 185 | 175211 | 57121 | 29719961 |
Serotonin syndrome | 39.84 | 10.22 | 28 | 175368 | 17863 | 29759219 |
Purpura | 39.14 | 10.22 | 138 | 175258 | 9829 | 29767253 |
Sedation | 38.65 | 10.22 | 24 | 175372 | 16349 | 29760733 |
Intentional product use issue | 38.39 | 10.22 | 99 | 175297 | 36341 | 29740741 |
Neuroleptic malignant syndrome | 38.31 | 10.22 | 24 | 175372 | 16271 | 29760811 |
Sepsis | 36.88 | 10.22 | 1120 | 174276 | 145275 | 29631807 |
Asthma | 36.80 | 10.22 | 100 | 175296 | 36074 | 29741008 |
Psychotic disorder | 35.72 | 10.22 | 44 | 175352 | 21471 | 29755611 |
Gouty tophus | 35.60 | 10.22 | 17 | 175379 | 121 | 29776961 |
Rhabdomyolysis | 35.45 | 10.22 | 546 | 174850 | 63034 | 29714048 |
Neutropenic sepsis | 34.97 | 10.22 | 146 | 175250 | 11263 | 29765819 |
Tumour flare | 34.79 | 10.22 | 27 | 175369 | 497 | 29776585 |
Immune reconstitution inflammatory syndrome | 34.20 | 10.22 | 6 | 175390 | 9095 | 29767987 |
Drug interaction | 33.88 | 10.22 | 1460 | 173936 | 198108 | 29578974 |
Product monitoring error | 33.51 | 10.22 | 46 | 175350 | 1695 | 29775387 |
Splenomegaly | 32.71 | 10.22 | 161 | 175235 | 13319 | 29763763 |
Somnolence | 32.17 | 10.22 | 387 | 175009 | 96376 | 29680706 |
Poisoning | 30.81 | 10.22 | 14 | 175382 | 11368 | 29765714 |
Haemoglobin decreased | 30.09 | 10.22 | 878 | 174518 | 113220 | 29663862 |
Multiple sclerosis relapse | 29.97 | 10.22 | 13 | 175383 | 10849 | 29766233 |
Abnormal behaviour | 29.05 | 10.22 | 67 | 175329 | 25556 | 29751526 |
Inappropriate schedule of product administration | 28.80 | 10.22 | 127 | 175269 | 39601 | 29737481 |
Device interaction | 28.30 | 10.22 | 22 | 175374 | 406 | 29776676 |
International normalised ratio increased | 28.17 | 10.22 | 414 | 174982 | 47325 | 29729757 |
Acute myeloid leukaemia | 27.94 | 10.22 | 191 | 175205 | 17815 | 29759267 |
Substance abuse | 27.90 | 10.22 | 4 | 175392 | 7036 | 29770046 |
Intentional self-injury | 27.80 | 10.22 | 23 | 175373 | 13509 | 29763573 |
Wrong technique in product usage process | 27.48 | 10.22 | 92 | 175304 | 31063 | 29746019 |
Hypercreatininaemia | 27.42 | 10.22 | 23 | 175373 | 475 | 29776607 |
Coma | 27.14 | 10.22 | 133 | 175263 | 40316 | 29736766 |
Drug hypersensitivity | 26.78 | 10.22 | 264 | 175132 | 68255 | 29708827 |
Synovitis | 26.54 | 10.22 | 12 | 175384 | 9771 | 29767311 |
Hepatitis C | 26.45 | 10.22 | 23 | 175373 | 13182 | 29763900 |
Irritability | 26.35 | 10.22 | 60 | 175336 | 22990 | 29754092 |
Incorrect route of product administration | 26.14 | 10.22 | 17 | 175379 | 11298 | 29765784 |
Blood potassium increased | 25.17 | 10.22 | 172 | 175224 | 16041 | 29761041 |
Product use issue | 25.06 | 10.22 | 162 | 175234 | 45854 | 29731228 |
Dyskinesia | 24.82 | 10.22 | 57 | 175339 | 21777 | 29755305 |
Vascular purpura | 24.63 | 10.22 | 38 | 175358 | 1559 | 29775523 |
Respiratory depression | 24.32 | 10.22 | 19 | 175377 | 11484 | 29765598 |
Nasopharyngitis | 24.16 | 10.22 | 224 | 175172 | 58625 | 29718457 |
Hospitalisation | 24.15 | 10.22 | 156 | 175240 | 44163 | 29732919 |
Bradycardia | 23.68 | 10.22 | 526 | 174870 | 65000 | 29712082 |
Haematoma | 23.54 | 10.22 | 229 | 175167 | 23724 | 29753358 |
Haematochezia | 23.53 | 10.22 | 305 | 175091 | 33917 | 29743165 |
Skin exfoliation | 23.50 | 10.22 | 223 | 175173 | 22949 | 29754133 |
Agitation | 23.43 | 10.22 | 203 | 175193 | 53870 | 29723212 |
Pelvic mass | 23.41 | 10.22 | 13 | 175383 | 131 | 29776951 |
Eczema | 23.29 | 10.22 | 146 | 175250 | 13223 | 29763859 |
Electrolyte depletion | 23.24 | 10.22 | 15 | 175381 | 203 | 29776879 |
Rash | 23.05 | 10.22 | 1358 | 174038 | 190531 | 29586551 |
Musculoskeletal stiffness | 22.36 | 10.22 | 121 | 175275 | 35760 | 29741322 |
Poisoning deliberate | 21.95 | 10.22 | 4 | 175392 | 5900 | 29771182 |
Blood lactic acid | 21.86 | 10.22 | 18 | 175378 | 362 | 29776720 |
Abnormal loss of weight | 21.75 | 10.22 | 60 | 175336 | 3742 | 29773340 |
Blood pressure fluctuation | 21.30 | 10.22 | 44 | 175352 | 17459 | 29759623 |
Erythema multiforme | 21.28 | 10.22 | 98 | 175298 | 7887 | 29769195 |
Presyncope | 21.28 | 10.22 | 164 | 175232 | 15892 | 29761190 |
Coating in mouth | 21.20 | 10.22 | 10 | 175386 | 69 | 29777013 |
Pancytopenia | 20.93 | 10.22 | 649 | 174747 | 84403 | 29692679 |
Blood electrolytes abnormal | 20.79 | 10.22 | 26 | 175370 | 873 | 29776209 |
Azotaemia | 20.69 | 10.22 | 70 | 175326 | 4882 | 29772200 |
Generalised tonic-clonic seizure | 20.68 | 10.22 | 53 | 175343 | 19498 | 29757584 |
Myocardial infarction | 20.57 | 10.22 | 569 | 174827 | 125056 | 29652026 |
Renal function test abnormal | 20.54 | 10.22 | 44 | 175352 | 2335 | 29774747 |
Therapeutic product effect decreased | 20.44 | 10.22 | 94 | 175302 | 28982 | 29748100 |
Anger | 20.36 | 10.22 | 21 | 175375 | 11099 | 29765983 |
Pathogen resistance | 20.31 | 10.22 | 12 | 175384 | 8398 | 29768684 |
White blood cell count decreased | 20.24 | 10.22 | 639 | 174757 | 83308 | 29693774 |
Base excess decreased | 20.18 | 10.22 | 14 | 175382 | 215 | 29776867 |
Oedema | 19.83 | 10.22 | 358 | 175038 | 42635 | 29734447 |
Gravitational oedema | 19.77 | 10.22 | 21 | 175375 | 589 | 29776493 |
Subacute hepatic failure | 19.45 | 10.22 | 10 | 175386 | 85 | 29776997 |
Lymphocytopenia neonatal | 19.43 | 10.22 | 6 | 175390 | 9 | 29777073 |
Vomiting | 19.40 | 10.22 | 1071 | 174325 | 218747 | 29558335 |
Haematuria | 19.18 | 10.22 | 369 | 175027 | 44465 | 29732617 |
Gastrointestinal haemorrhage | 19.03 | 10.22 | 631 | 174765 | 82815 | 29694267 |
Product quality issue | 19.02 | 10.22 | 52 | 175344 | 18722 | 29758360 |
Erysipelas | 18.95 | 10.22 | 64 | 175332 | 4460 | 29772622 |
Post transplant lymphoproliferative disorder | 18.87 | 10.22 | 4 | 175392 | 5302 | 29771780 |
Atrial septal defect | 18.52 | 10.22 | 8 | 175388 | 6693 | 29770389 |
Dialysis | 18.48 | 10.22 | 119 | 175277 | 10877 | 29766205 |
C-reactive protein abnormal | 18.36 | 10.22 | 5 | 175391 | 5588 | 29771494 |
Blood count abnormal | 18.32 | 10.22 | 124 | 175272 | 11528 | 29765554 |
Skin swelling | 18.19 | 10.22 | 25 | 175371 | 922 | 29776160 |
Oligoasthenozoospermia | 18.04 | 10.22 | 6 | 175390 | 13 | 29777069 |
Asthenia | 18.02 | 10.22 | 1517 | 173879 | 219773 | 29557309 |
Hyponatraemia | 17.93 | 10.22 | 518 | 174878 | 66684 | 29710398 |
Blood urea abnormal | 17.93 | 10.22 | 21 | 175375 | 658 | 29776424 |
Post-traumatic amnestic disorder | 17.88 | 10.22 | 8 | 175388 | 48 | 29777034 |
No adverse event | 17.83 | 10.22 | 48 | 175348 | 17371 | 29759711 |
Intestinal haemorrhage | 17.80 | 10.22 | 50 | 175346 | 3151 | 29773931 |
Restlessness | 17.77 | 10.22 | 70 | 175326 | 22529 | 29754553 |
Withdrawal syndrome | 17.65 | 10.22 | 24 | 175372 | 11226 | 29765856 |
Tooth deposit | 17.49 | 10.22 | 10 | 175386 | 107 | 29776975 |
Epidermolysis | 17.40 | 10.22 | 14 | 175382 | 272 | 29776810 |
Pleural effusion | 17.38 | 10.22 | 562 | 174834 | 73504 | 29703578 |
Blood uric acid abnormal | 17.35 | 10.22 | 9 | 175387 | 78 | 29777004 |
Electrolyte imbalance | 17.26 | 10.22 | 121 | 175275 | 11379 | 29765703 |
Respiratory tract haemorrhage | 17.25 | 10.22 | 23 | 175373 | 824 | 29776258 |
Thrombotic microangiopathy | 17.24 | 10.22 | 15 | 175381 | 8595 | 29768487 |
Diabetic ketoacidosis | 17.17 | 10.22 | 43 | 175353 | 15943 | 29761139 |
Labelled drug-drug interaction medication error | 17.08 | 10.22 | 113 | 175283 | 10425 | 29766657 |
Tubulointerstitial nephritis | 17.07 | 10.22 | 170 | 175226 | 17721 | 29759361 |
Unresponsive to stimuli | 17.07 | 10.22 | 88 | 175308 | 26331 | 29750751 |
Differentiation syndrome | 17.05 | 10.22 | 27 | 175369 | 1133 | 29775949 |
Heart rate increased | 16.94 | 10.22 | 145 | 175251 | 38576 | 29738506 |
Acute graft versus host disease in skin | 16.92 | 10.22 | 3 | 175393 | 4513 | 29772569 |
Dehydration | 16.91 | 10.22 | 885 | 174511 | 122654 | 29654428 |
Haemodialysis | 16.91 | 10.22 | 117 | 175279 | 10956 | 29766126 |
Arthralgia | 16.74 | 10.22 | 638 | 174758 | 135153 | 29641929 |
Febrile infection | 16.71 | 10.22 | 33 | 175363 | 1652 | 29775430 |
Crying | 16.65 | 10.22 | 6 | 175390 | 5603 | 29771479 |
Graft versus host disease | 16.59 | 10.22 | 21 | 175375 | 10129 | 29766953 |
Stag horn calculus | 16.59 | 10.22 | 4 | 175392 | 0 | 29777082 |
Pneumonia aspiration | 16.29 | 10.22 | 142 | 175254 | 37638 | 29739444 |
Hallucination, auditory | 16.27 | 10.22 | 20 | 175376 | 9769 | 29767313 |
Oroantral fistula | 16.23 | 10.22 | 13 | 175383 | 251 | 29776831 |
Acute graft versus host disease | 16.21 | 10.22 | 7 | 175389 | 5857 | 29771225 |
Orthostatic hypotension | 16.18 | 10.22 | 213 | 175183 | 23766 | 29753316 |
Colitis ulcerative | 16.15 | 10.22 | 38 | 175358 | 14396 | 29762686 |
Loss of personal independence in daily activities | 16.12 | 10.22 | 68 | 175328 | 21467 | 29755615 |
Accidental overdose | 16.09 | 10.22 | 54 | 175342 | 18221 | 29758861 |
Diverticulum intestinal | 16.08 | 10.22 | 49 | 175347 | 3233 | 29773849 |
Drug therapeutic incompatibility | 16.03 | 10.22 | 10 | 175386 | 127 | 29776955 |
Serum ferritin abnormal | 16.02 | 10.22 | 12 | 175384 | 209 | 29776873 |
Respiratory fatigue | 15.97 | 10.22 | 8 | 175388 | 64 | 29777018 |
Depressed mood | 15.91 | 10.22 | 49 | 175347 | 16980 | 29760102 |
Oxygen consumption decreased | 15.91 | 10.22 | 11 | 175385 | 168 | 29776914 |
Sarcopenia | 15.80 | 10.22 | 13 | 175383 | 261 | 29776821 |
Appendicolith | 15.79 | 10.22 | 23 | 175373 | 896 | 29776186 |
Dyspnoea | 15.71 | 10.22 | 2203 | 173193 | 331092 | 29445990 |
Portal vein flow decreased | 15.64 | 10.22 | 5 | 175391 | 9 | 29777073 |
Mucosal necrosis | 15.56 | 10.22 | 8 | 175388 | 68 | 29777014 |
Accidental exposure to product | 15.45 | 10.22 | 22 | 175374 | 10093 | 29766989 |
Hyperphosphataemia | 15.33 | 10.22 | 38 | 175358 | 2221 | 29774861 |
Sexual dysfunction | 15.30 | 10.22 | 8 | 175388 | 5993 | 29771089 |
Unevaluable event | 15.29 | 10.22 | 116 | 175280 | 31669 | 29745413 |
Psoriasis | 15.28 | 10.22 | 167 | 175229 | 42339 | 29734743 |
Metabolic acidosis | 15.24 | 10.22 | 306 | 175090 | 37155 | 29739927 |
Abnormal dreams | 15.23 | 10.22 | 15 | 175381 | 8100 | 29768982 |
Hypercalcaemia | 15.12 | 10.22 | 125 | 175271 | 12370 | 29764712 |
Mucormycosis | 15.03 | 10.22 | 6 | 175390 | 5262 | 29771820 |
Psoriatic arthropathy | 14.98 | 10.22 | 45 | 175351 | 15716 | 29761366 |
Aplasia pure red cell | 14.96 | 10.22 | 69 | 175327 | 5557 | 29771525 |
Dermatitis allergic | 14.77 | 10.22 | 70 | 175326 | 5702 | 29771380 |
Ventricular internal diameter abnormal | 14.75 | 10.22 | 7 | 175389 | 49 | 29777033 |
Paranoia | 14.74 | 10.22 | 23 | 175373 | 10165 | 29766917 |
Skin reaction | 14.73 | 10.22 | 59 | 175337 | 4466 | 29772616 |
Acquired epidermolysis bullosa | 14.68 | 10.22 | 5 | 175391 | 12 | 29777070 |
Ichthyosis acquired | 14.68 | 10.22 | 5 | 175391 | 12 | 29777070 |
Malignant neoplasm progression | 14.66 | 10.22 | 317 | 175079 | 71970 | 29705112 |
Prostate cancer recurrent | 14.61 | 10.22 | 20 | 175376 | 735 | 29776347 |
Speech disorder | 14.54 | 10.22 | 84 | 175312 | 24428 | 29752654 |
Nephrogenic anaemia | 14.53 | 10.22 | 36 | 175360 | 2103 | 29774979 |
Schizophrenia | 14.50 | 10.22 | 19 | 175377 | 9029 | 29768053 |
Bronchospasm | 14.34 | 10.22 | 24 | 175372 | 10314 | 29766768 |
Tricuspid valve incompetence | 14.30 | 10.22 | 93 | 175303 | 8530 | 29768552 |
Genital ulceration | 14.12 | 10.22 | 10 | 175386 | 159 | 29776923 |
Immune effector cell-associated neurotoxicity syndrome | 14.10 | 10.22 | 21 | 175375 | 835 | 29776247 |
Product prescribing error | 14.08 | 10.22 | 155 | 175241 | 16578 | 29760504 |
Crohn's disease | 14.08 | 10.22 | 4 | 175392 | 4348 | 29772734 |
Intestinal angioedema | 13.96 | 10.22 | 10 | 175386 | 162 | 29776920 |
Dependence on oxygen therapy | 13.87 | 10.22 | 9 | 175387 | 123 | 29776959 |
Thrombin time prolonged | 13.86 | 10.22 | 10 | 175386 | 164 | 29776918 |
Carcinoma in situ of skin | 13.73 | 10.22 | 8 | 175388 | 89 | 29776993 |
Epilepsy | 13.71 | 10.22 | 66 | 175330 | 20103 | 29756979 |
Eczema nummular | 13.62 | 10.22 | 9 | 175387 | 127 | 29776955 |
Hypertrophy | 13.55 | 10.22 | 13 | 175383 | 322 | 29776760 |
Subcutaneous haematoma | 13.50 | 10.22 | 22 | 175374 | 946 | 29776136 |
Cardiac failure chronic | 13.50 | 10.22 | 69 | 175327 | 5794 | 29771288 |
Hepatosplenomegaly | 13.47 | 10.22 | 50 | 175346 | 3651 | 29773431 |
Tachyarrhythmia | 13.44 | 10.22 | 44 | 175352 | 3017 | 29774065 |
Vasculitis necrotising | 13.38 | 10.22 | 17 | 175379 | 580 | 29776502 |
Human herpesvirus 6 infection | 13.35 | 10.22 | 33 | 175363 | 1925 | 29775157 |
Reactive gastropathy | 13.21 | 10.22 | 10 | 175386 | 177 | 29776905 |
Decreased gait velocity | 13.21 | 10.22 | 8 | 175388 | 96 | 29776986 |
Aptyalism | 13.16 | 10.22 | 11 | 175385 | 226 | 29776856 |
Mantle cell lymphoma refractory | 13.14 | 10.22 | 8 | 175388 | 97 | 29776985 |
Lip erosion | 13.12 | 10.22 | 17 | 175379 | 592 | 29776490 |
Acne | 13.00 | 10.22 | 22 | 175374 | 9414 | 29767668 |
Low birth weight baby | 12.89 | 10.22 | 10 | 175386 | 6066 | 29771016 |
Oesophagobronchial fistula | 12.88 | 10.22 | 9 | 175387 | 140 | 29776942 |
Hypocalcaemia | 12.85 | 10.22 | 186 | 175210 | 21190 | 29755892 |
Urate nephropathy | 12.80 | 10.22 | 5 | 175391 | 20 | 29777062 |
Scrotal erythema | 12.80 | 10.22 | 5 | 175391 | 20 | 29777062 |
Gastritis haemorrhagic | 12.71 | 10.22 | 24 | 175372 | 1162 | 29775920 |
Cardioactive drug level increased | 12.67 | 10.22 | 29 | 175367 | 1610 | 29775472 |
Drug screen positive | 12.60 | 10.22 | 5 | 175391 | 4402 | 29772680 |
Tooth infection | 12.59 | 10.22 | 62 | 175334 | 5129 | 29771953 |
Paroxysmal arrhythmia | 12.58 | 10.22 | 4 | 175392 | 7 | 29777075 |
Drug abuser | 12.57 | 10.22 | 5 | 175391 | 4396 | 29772686 |
Dysarthria | 12.53 | 10.22 | 116 | 175280 | 30374 | 29746708 |
Fear | 12.51 | 10.22 | 28 | 175368 | 10797 | 29766285 |
Full blood count decreased | 12.50 | 10.22 | 144 | 175252 | 15573 | 29761509 |
Acute cutaneous lupus erythematosus | 12.48 | 10.22 | 7 | 175389 | 72 | 29777010 |
Heat stroke | 12.45 | 10.22 | 20 | 175376 | 850 | 29776232 |
HLA-B*5801 assay positive | 12.44 | 10.22 | 3 | 175393 | 0 | 29777082 |
Oesophageal mucosal blister | 12.44 | 10.22 | 3 | 175393 | 0 | 29777082 |
Surgical vascular shunt | 12.44 | 10.22 | 3 | 175393 | 0 | 29777082 |
Neonatal respiratory distress syndrome | 12.41 | 10.22 | 4 | 175392 | 4008 | 29773074 |
Strangury | 12.41 | 10.22 | 8 | 175388 | 108 | 29776974 |
Microphthalmos | 12.40 | 10.22 | 10 | 175386 | 195 | 29776887 |
Mental disorder | 12.35 | 10.22 | 39 | 175357 | 13410 | 29763672 |
Neck pain | 12.30 | 10.22 | 72 | 175324 | 20872 | 29756210 |
Hypomagnesaemia | 12.29 | 10.22 | 150 | 175246 | 16448 | 29760634 |
Narrow anterior chamber angle | 12.24 | 10.22 | 4 | 175392 | 8 | 29777074 |
Treatment noncompliance | 12.22 | 10.22 | 92 | 175304 | 25161 | 29751921 |
Transplant rejection | 12.19 | 10.22 | 22 | 175374 | 9184 | 29767898 |
Cardiac failure acute | 12.17 | 10.22 | 94 | 175302 | 9115 | 29767967 |
Hyperamylasaemia | 12.09 | 10.22 | 16 | 175380 | 569 | 29776513 |
Aortic valve stenosis | 11.98 | 10.22 | 29 | 175367 | 1670 | 29775412 |
Oral mucosa erosion | 11.97 | 10.22 | 19 | 175377 | 799 | 29776283 |
Blood pressure increased | 11.96 | 10.22 | 325 | 175071 | 71603 | 29705479 |
Adenovirus infection | 11.95 | 10.22 | 5 | 175391 | 4263 | 29772819 |
Device issue | 11.94 | 10.22 | 17 | 175379 | 7799 | 29769283 |
Lichenoid keratosis | 11.93 | 10.22 | 33 | 175363 | 2061 | 29775021 |
Multiple sclerosis | 11.92 | 10.22 | 15 | 175381 | 7252 | 29769830 |
Drug ineffective for unapproved indication | 11.89 | 10.22 | 29 | 175367 | 10851 | 29766231 |
Pruritus | 11.87 | 10.22 | 824 | 174572 | 117380 | 29659702 |
Brain natriuretic peptide increased | 11.87 | 10.22 | 51 | 175345 | 3984 | 29773098 |
Rash pustular | 11.72 | 10.22 | 59 | 175337 | 4924 | 29772158 |
Anaphylactic reaction | 11.70 | 10.22 | 106 | 175290 | 27876 | 29749206 |
Hypersensitivity vasculitis | 11.69 | 10.22 | 48 | 175348 | 3675 | 29773407 |
Rash macular | 11.64 | 10.22 | 102 | 175294 | 10265 | 29766817 |
Mantle cell lymphoma | 11.62 | 10.22 | 27 | 175369 | 1514 | 29775568 |
Hypocoagulable state | 11.61 | 10.22 | 20 | 175376 | 901 | 29776181 |
Rectal haemorrhage | 11.54 | 10.22 | 277 | 175119 | 34662 | 29742420 |
Injection site reaction | 11.51 | 10.22 | 29 | 175367 | 10731 | 29766351 |
Hallucination | 11.49 | 10.22 | 210 | 175186 | 48849 | 29728233 |
Feeling abnormal | 11.48 | 10.22 | 249 | 175147 | 56507 | 29720575 |
Injection site erythema | 11.42 | 10.22 | 42 | 175354 | 13792 | 29763290 |
Obsessive-compulsive disorder | 11.36 | 10.22 | 5 | 175391 | 4136 | 29772946 |
Rhinorrhoea | 11.33 | 10.22 | 73 | 175323 | 20681 | 29756401 |
Rash vesicular | 11.22 | 10.22 | 36 | 175360 | 2442 | 29774640 |
Rash morbilliform | 11.02 | 10.22 | 36 | 175360 | 2466 | 29774616 |
Actinic keratosis | 10.96 | 10.22 | 46 | 175350 | 3557 | 29773525 |
Diverticulum intestinal haemorrhagic | 10.95 | 10.22 | 32 | 175364 | 2063 | 29775019 |
Catatonia | 10.93 | 10.22 | 6 | 175390 | 4374 | 29772708 |
Tremor | 10.91 | 10.22 | 347 | 175049 | 75016 | 29702066 |
Atrioventricular block complete | 10.91 | 10.22 | 86 | 175310 | 8391 | 29768691 |
Mastitis | 10.89 | 10.22 | 9 | 175387 | 182 | 29776900 |
Injection site pruritus | 10.89 | 10.22 | 10 | 175386 | 5582 | 29771500 |
Dyspnoea exertional | 10.84 | 10.22 | 278 | 175118 | 35152 | 29741930 |
Jaundice cholestatic | 10.79 | 10.22 | 54 | 175342 | 4497 | 29772585 |
Granulomatous liver disease | 10.70 | 10.22 | 14 | 175382 | 492 | 29776590 |
Brain oedema | 10.66 | 10.22 | 37 | 175359 | 12361 | 29764721 |
Hypoaesthesia | 10.65 | 10.22 | 239 | 175157 | 53991 | 29723091 |
Aortic dissection | 10.63 | 10.22 | 35 | 175361 | 2407 | 29774675 |
Underdose | 10.60 | 10.22 | 36 | 175360 | 12105 | 29764977 |
Lymphadenopathy | 10.55 | 10.22 | 201 | 175195 | 24175 | 29752907 |
Interstitial lung disease | 10.53 | 10.22 | 442 | 174954 | 59755 | 29717327 |
Hypoglycaemia | 10.49 | 10.22 | 381 | 175015 | 50600 | 29726482 |
Left ventricular enlargement | 10.48 | 10.22 | 15 | 175381 | 575 | 29776507 |
Cancer fatigue | 10.42 | 10.22 | 5 | 175391 | 36 | 29777046 |
Mucosal haemorrhage | 10.40 | 10.22 | 25 | 175371 | 1433 | 29775649 |
Memory impairment | 10.40 | 10.22 | 154 | 175242 | 37020 | 29740062 |
Glossopharyngeal nerve paralysis | 10.38 | 10.22 | 3 | 175393 | 3 | 29777079 |
Purpura non-thrombocytopenic | 10.38 | 10.22 | 3 | 175393 | 3 | 29777079 |
Glomerular filtration rate decreased | 10.38 | 10.22 | 107 | 175289 | 11255 | 29765827 |
Transfusion reaction | 10.37 | 10.22 | 19 | 175377 | 899 | 29776183 |
Mood swings | 10.30 | 10.22 | 18 | 175378 | 7608 | 29769474 |
Small for dates baby | 10.28 | 10.22 | 3 | 175393 | 3205 | 29773877 |
Influenza like illness | 10.27 | 10.22 | 98 | 175298 | 25507 | 29751575 |
Sleep inertia | 10.24 | 10.22 | 4 | 175392 | 16 | 29777066 |
Amnesia | 10.22 | 10.22 | 92 | 175304 | 24229 | 29752853 |
Source | Code | Description |
---|---|---|
ATC | M04AA01 | MUSCULO-SKELETAL SYSTEM ANTIGOUT PREPARATIONS ANTIGOUT PREPARATIONS Preparations inhibiting uric acid production |
ATC | M04AA51 | MUSCULO-SKELETAL SYSTEM ANTIGOUT PREPARATIONS ANTIGOUT PREPARATIONS Preparations inhibiting uric acid production |
FDA MoA | N0000000206 | Xanthine Oxidase Inhibitors |
FDA EPC | N0000175698 | Xanthine Oxidase Inhibitor |
MeSH PA | D000963 | Antimetabolites |
MeSH PA | D000975 | Antioxidants |
MeSH PA | D018501 | Antirheumatic Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D016166 | Free Radical Scavengers |
MeSH PA | D006074 | Gout Suppressants |
MeSH PA | D009676 | Noxae |
CHEBI has role | CHEBI:35221 | antimetabolite |
CHEBI has role | CHEBI:35634 | xanthine oxidase inhibitors |
CHEBI has role | CHEBI:35845 | gout suppressants |
CHEBI has role | CHEBI:48578 | free-radical scavenger |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Hyperuricemia | indication | 35885006 | DOID:1920 |
Articular gout | indication | 48440001 | DOID:13189 |
Gout | indication | 90560007 | DOID:13189 |
Uric acid renal calculus | indication | 274401005 | |
Calcium renal calculus | indication | 427649000 | |
Uric Acid Nephropathy Gout | indication | ||
Chemotherapy-Induced Hyperuricemia | indication | ||
Recurrent Calcium Renal Calculi | indication | ||
Adjunctive treatment for bipolar disorder | off-label use | 13746004 | DOID:3312 |
Deficiency of adenine phosphoribosyltransferase | off-label use | 124274002 | DOID:0060350 |
Deficiency of ribose-phosphate pyrophosphokinase | off-label use | 124343001 | |
Neonatal Phosphoribosylpyrophosphate Synthetase Superactivity | off-label use | ||
Dehydration | contraindication | 34095006 | |
Chronic heart failure | contraindication | 48447003 | |
Hypersensitivity angiitis | contraindication | 60555002 | |
Impaired renal function disorder | contraindication | 197663003 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.52 | acidic |
pKa2 | 9.43 | acidic |
pKa3 | 1.45 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Xanthine dehydrogenase/oxidase | Enzyme | INHIBITOR | Ki | 5.15 | CHEMBL | CHEMBL | |||
Hypoxanthine-guanine phosphoribosyltransferase | Enzyme | WOMBAT-PK | |||||||
Xanthine dehydrogenase/oxidase | Enzyme | Ki | 6 | CHEMBL | |||||
Xanthine dehydrogenase/oxidase | Enzyme | IC50 | 6.12 | CHEMBL |
ID | Source |
---|---|
63CZ7GJN5I | UNII |
4017895 | VUID |
N0000146247 | NUI |
D00224 | KEGG_DRUG |
17795-21-0 | SECONDARY_CAS_RN |
C0002144 | UMLSCUI |
CHEBI:40279 | CHEBI |
CHEMBL1467 | ChEMBL_ID |
CHEMBL1200477 | ChEMBL_ID |
DB00437 | DRUGBANK_ID |
D000493 | MESH_DESCRIPTOR_UI |
135401907 | PUBCHEM_CID |
1731 | INN_ID |
6795 | IUPHAR_LIGAND_ID |
203600 | RXNORM |
1590 | MMSL |
1816 | MMSL |
4150 | MMSL |
8255 | MMSL |
8256 | MMSL |
d00023 | MMSL |
001084 | NDDF |
005000 | NDDF |
25246002 | SNOMEDCT_US |
387135004 | SNOMEDCT_US |
425496004 | SNOMEDCT_US |
4017895 | VANDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Allopurinol sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9533 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 500 mg | INTRAVENOUS | ANDA | 20 sections |
Allopurinol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0137 | TABLET | 100 mg | ORAL | ANDA | 20 sections |
Allopurinol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0181 | TABLET | 300 mg | ORAL | ANDA | 20 sections |
Allopurinol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-5543 | TABLET | 100 mg | ORAL | NDA | 20 sections |
Allopurinol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-5544 | TABLET | 300 mg | ORAL | NDA | 20 sections |
Allopurinol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0603-2115 | TABLET | 100 mg | ORAL | ANDA | 12 sections |
Allopurinol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0603-2116 | TABLET | 300 mg | ORAL | ANDA | 12 sections |
Allopurinol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-1592 | TABLET | 100 mg | ORAL | ANDA | 21 sections |
Allopurinol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-1593 | TABLET | 300 mg | ORAL | ANDA | 21 sections |
Allopurinol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8321 | TABLET | 100 mg | ORAL | NDA | 20 sections |
Allopurinol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8385 | TABLET | 100 mg | ORAL | ANDA | 12 sections |
Allopurinol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6571 | TABLET | 100 mg | ORAL | ANDA | 12 sections |
Allopurinol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6572 | TABLET | 300 mg | ORAL | ANDA | 12 sections |
Allopurinol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7041 | TABLET | 100 mg | ORAL | ANDA | 16 sections |
Allopurinol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-545 | TABLET | 100 mg | ORAL | ANDA | 17 sections |
Allopurinol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-547 | TABLET | 300 mg | ORAL | ANDA | 17 sections |
Allopurinol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-911 | TABLET | 300 mg | ORAL | ANDA | 19 sections |
Allopurinol | Human Prescription Drug Label | 1 | 16714-041 | TABLET | 100 mg | ORAL | ANDA | 21 sections |
Allopurinol | Human Prescription Drug Label | 1 | 16714-042 | TABLET | 300 mg | ORAL | ANDA | 21 sections |
Allopurinol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-134 | TABLET | 100 mg | ORAL | ANDA | 20 sections |
Allopurinol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-135 | TABLET | 300 mg | ORAL | ANDA | 20 sections |
Allopurinol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-246 | TABLET | 300 mg | ORAL | ANDA | 21 sections |
Allopurinol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-836 | TABLET | 100 mg | ORAL | ANDA | 21 sections |
Allopurinol | Human Prescription Drug Label | 1 | 23155-693 | TABLET | 100 mg | ORAL | ANDA | 19 sections |
Allopurinol | Human Prescription Drug Label | 1 | 23155-694 | TABLET | 300 mg | ORAL | ANDA | 19 sections |
Allopurinol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 29300-349 | TABLET | 100 mg | ORAL | ANDA | 15 sections |
Allopurinol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 29300-350 | TABLET | 300 mg | ORAL | ANDA | 15 sections |
Allopurinol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-597 | TABLET | 300 mg | ORAL | NDA | 20 sections |
Allopurinol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-810 | TABLET | 100 mg | ORAL | NDA | 20 sections |
ALLOPURINOL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42549-500 | TABLET | 100 mg | ORAL | ANDA | 20 sections |