leucovorin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1232 58-05-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sodium folinate
  • folinic acid
  • leucovorin
  • calcium folinate
  • leucovorin calcium
  • folinic acid calcium salt
  • folinic acid calcium
  • wellcovorin
  • folinic acid calcium salt pentahydrate
The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS.
  • Molecular weight: 473.45
  • Formula: C20H23N7O7
  • CLOGP: -1.98
  • LIPINSKI: 2
  • HAC: 14
  • HDO: 7
  • TPSA: 215.55
  • ALOGS: -3.20
  • ROTB: 9

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
60 mg O
60 mg P
60 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 500 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 10 % Benet LZ, Broccatelli F, Oprea TI
BA (Bioavailability) 4 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.25 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 5.80 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.09 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.30 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
June 20, 1952 FDA
Nov. 25, 2021 PMDA PFIZER JAPAN INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neutropenia 962.33 11.98 938 48797 147027 50408362
Neuropathy peripheral 460.38 11.98 520 49215 96237 50459152
Neurotoxicity 445.97 11.98 239 49496 14501 50540888
Mucosal inflammation 387.99 11.98 319 49416 39823 50515566
Thrombocytopenia 366.54 11.98 534 49201 127139 50428250
Diarrhoea 305.82 11.98 1262 48473 587214 49968175
Skin toxicity 259.50 11.98 109 49626 3804 50551585
Disease progression 256.26 11.98 388 49347 95478 50459911
Febrile neutropenia 232.79 11.98 375 49360 97292 50458097
Haematotoxicity 213.78 11.98 119 49616 7776 50547613
Polyneuropathy 197.45 11.98 132 49603 11999 50543390
Leukopenia 187.03 11.98 278 49457 67250 50488139
Dermatitis acneiform 173.02 11.98 83 49652 3974 50551415
Stomatitis 148.92 11.98 316 49419 101028 50454361
Vomiting 144.19 11.98 857 48878 459901 50095488
Posterior reversible encephalopathy syndrome 130.42 11.98 112 49623 14816 50540573
Systemic lupus erythematosus 120.22 11.98 4 49731 140618 50414771
Pulmonary embolism 114.97 11.98 286 49449 101418 50453971
Palmar-plantar erythrodysaesthesia syndrome 114.56 11.98 119 49616 19979 50535410
Pancytopenia 114.25 11.98 254 49481 83776 50471613
Anaemia 112.14 11.98 518 49217 251938 50303451
Nausea 111.38 11.98 1118 48617 704280 49851109
Arteriospasm coronary 108.03 11.98 57 49678 3345 50552044
Enteritis 104.03 11.98 72 49663 6923 50548466
Malignant neoplasm progression 100.67 11.98 213 49522 67911 50487478
Non-cirrhotic portal hypertension 100.09 11.98 25 49710 147 50555242
Abdominal pain 99.97 11.98 478 49257 235750 50319639
Gastrointestinal toxicity 98.77 11.98 60 49675 4617 50550772
Bone marrow failure 97.74 11.98 128 49607 27496 50527893
Drug clearance decreased 96.75 11.98 38 49697 1111 50554278
Metastases to liver 93.59 11.98 107 49628 19997 50535392
Glossodynia 93.09 11.98 5 49730 115564 50439825
Focal nodular hyperplasia 89.93 11.98 29 49706 468 50554921
Arthropathy 79.41 11.98 28 49707 157878 50397511
Product dose omission issue 79.07 11.98 41 49694 183797 50371592
Peripheral swelling 75.96 11.98 55 49680 205881 50349508
Swelling 74.93 11.98 53 49682 200819 50354570
Proteinuria 73.33 11.98 86 49649 16511 50538878
Gastrointestinal perforation 71.75 11.98 42 49693 3019 50552370
Myelosuppression 68.14 11.98 75 49660 13442 50541947
Hypomagnesaemia 66.44 11.98 97 49638 23059 50532330
Colorectal cancer metastatic 65.29 11.98 23 49712 492 50554897
Human bocavirus infection 64.21 11.98 21 49714 355 50555034
Secondary immunodeficiency 62.14 11.98 28 49707 1160 50554229
Paronychia 60.97 11.98 44 49691 4520 50550869
Hypertension 60.11 11.98 384 49351 210819 50344570
Fall 59.27 11.98 153 49582 334779 50220610
Peripheral sensory neuropathy 58.68 11.98 50 49685 6541 50548848
Dehydration 57.65 11.98 299 49436 152150 50403239
Dysarthria 56.45 11.98 118 49617 37285 50518104
Portal hypertension 55.40 11.98 37 49698 3355 50552034
Pneumatosis intestinalis 55.02 11.98 31 49704 2072 50553317
Therapy partial responder 54.63 11.98 48 49687 6543 50548846
Loss of employment 54.44 11.98 28 49707 1558 50553831
General physical health deterioration 53.60 11.98 279 49456 142155 50413234
Off label use 51.25 11.98 700 49035 473726 50081663
Synovitis 51.22 11.98 29 49706 123836 50431553
Insomnia 50.99 11.98 58 49677 174807 50380582
Hyperammonaemia 50.80 11.98 40 49695 4684 50550705
Neoplasm progression 49.98 11.98 97 49638 29060 50526329
Splenomegaly 49.38 11.98 54 49681 9606 50545783
Abdominal discomfort 48.94 11.98 96 49639 231545 50323844
Metastases to lung 48.51 11.98 57 49678 10963 50544426
Hand deformity 48.28 11.98 19 49716 100180 50455209
Gene mutation 48.19 11.98 24 49711 1247 50554142
Pyrexia 47.78 11.98 577 49158 379626 50175763
Pericarditis 46.93 11.98 10 49725 78679 50476710
Wound 46.34 11.98 23 49712 105771 50449618
Hyperammonaemic encephalopathy 45.73 11.98 27 49708 1972 50553417
Discomfort 45.35 11.98 25 49710 108355 50447034
Pain 45.09 11.98 359 49376 578544 49976845
Enterobacter infection 44.50 11.98 26 49709 1862 50553527
Lower respiratory tract infection 44.33 11.98 19 49716 95182 50460207
Leukoencephalopathy 44.19 11.98 34 49701 3849 50551540
Hospitalisation 44.02 11.98 7 49728 67930 50487459
Cholangitis 43.37 11.98 36 49699 4543 50550846
Ileus 43.26 11.98 59 49676 13170 50542219
Metastases to meninges 43.09 11.98 26 49709 1976 50553413
Hepatocellular injury 42.87 11.98 85 49650 25862 50529527
Intestinal perforation 42.52 11.98 52 49683 10427 50544962
Crystal nephropathy 41.97 11.98 19 49716 796 50554593
Drug abuse 41.52 11.98 5 49730 59841 50495548
Hypersensitivity vasculitis 41.04 11.98 33 49702 3982 50551407
Steatohepatitis 40.82 11.98 16 49719 465 50554924
Neutrophil count decreased 40.43 11.98 118 49617 45908 50509481
Drug hypersensitivity 40.38 11.98 120 49615 250890 50304499
Herpes simplex 40.07 11.98 42 49693 7120 50548269
Cystitis radiation 39.58 11.98 10 49725 62 50555327
Atypical haemolytic uraemic syndrome 38.55 11.98 16 49719 541 50554848
Bladder tamponade 38.41 11.98 10 49725 71 50555318
Gastroenteritis norovirus 38.41 11.98 23 49712 1724 50553665
Venous thrombosis 37.97 11.98 33 49702 4433 50550956
Hepatic enzyme increased 37.45 11.98 48 49687 137332 50418057
Contraindicated product administered 36.67 11.98 56 49679 148902 50406487
Epistaxis 36.65 11.98 142 49593 63812 50491577
Hypokalaemia 36.34 11.98 177 49558 87815 50467574
Interstitial lung disease 36.32 11.98 125 49610 53051 50502338
Neuromyotonia 36.16 11.98 9 49726 52 50555337
Factor VII deficiency 35.86 11.98 8 49727 26 50555363
Embolism 35.70 11.98 39 49696 6929 50548460
Mucosal toxicity 35.62 11.98 13 49722 309 50555080
Leukoerythroblastosis 35.49 11.98 12 49723 226 50555163
Rash pustular 34.48 11.98 37 49698 6444 50548945
Neoplasm recurrence 34.32 11.98 24 49711 2345 50553044
Injury 34.16 11.98 4 49731 48921 50506468
Joint swelling 34.11 11.98 125 49610 245161 50310228
Venous pressure jugular decreased 33.81 11.98 8 49727 36 50555353
Dizziness 33.71 11.98 201 49534 346168 50209221
Depression 33.68 11.98 70 49665 165353 50390036
Trichomegaly 33.45 11.98 8 49727 38 50555351
Blood cholesterol increased 32.95 11.98 7 49728 55208 50500181
Short-bowel syndrome 32.69 11.98 13 49722 393 50554996
Ascites 32.52 11.98 93 49642 35768 50519621
Helicobacter infection 32.47 11.98 5 49730 49697 50505692
Immune thrombocytopenia 32.22 11.98 42 49693 8975 50546414
Nicotinic acid deficiency 32.18 11.98 8 49727 46 50555343
Cardiotoxicity 32.02 11.98 37 49698 6990 50548399
Myelodysplastic syndrome 31.82 11.98 55 49680 15077 50540312
Thrombocytopenic purpura 31.61 11.98 18 49717 1228 50554161
Laryngospasm 31.61 11.98 24 49711 2664 50552725
Sepsis 31.41 11.98 231 49504 132694 50422695
Septic shock 31.18 11.98 125 49610 57050 50498339
Duodenal ulcer perforation 31.18 11.98 4 49731 45607 50509782
Drug ineffective 30.97 11.98 594 49141 818739 49736650
Aortic thrombosis 29.79 11.98 16 49719 973 50554416
Cholestasis 29.25 11.98 72 49663 25329 50530060
Anastomotic leak 28.96 11.98 12 49723 404 50554985
Nasal septum perforation 28.89 11.98 14 49721 685 50554704
Stress cardiomyopathy 28.59 11.98 37 49698 7850 50547539
Intestinal obstruction 28.51 11.98 73 49662 26310 50529079
Vena cava thrombosis 28.18 11.98 20 49715 2001 50553388
Injection site pain 28.03 11.98 41 49694 110983 50444406
Encapsulating peritoneal sclerosis 27.83 11.98 11 49724 327 50555062
Rhinovirus infection 27.82 11.98 25 49710 3509 50551880
Device related infection 27.38 11.98 62 49673 20673 50534716
Pain in extremity 27.24 11.98 157 49578 272708 50282681
Carcinoembryonic antigen increased 26.32 11.98 17 49718 1457 50553932
Catabolic state 26.05 11.98 7 49728 57 50555332
Wrong technique in product usage process 25.96 11.98 11 49724 55499 50499890
Contusion 25.88 11.98 44 49691 112139 50443250
Sinusitis 25.66 11.98 84 49651 170474 50384915
Tumour lysis syndrome 25.64 11.98 34 49701 7387 50548002
Aortic intramural haematoma 25.63 11.98 7 49728 61 50555328
Haemolytic anaemia 25.32 11.98 38 49697 9254 50546135
Chills 25.14 11.98 172 49563 96515 50458874
Female genital tract fistula 25.12 11.98 24 49711 3642 50551747
Large intestinal obstruction 25.10 11.98 18 49717 1831 50553558
ECG signs of myocardial ischaemia 25.04 11.98 7 49728 67 50555322
Respiratory symptom 25.01 11.98 20 49715 2394 50552995
Myeloid leukaemia 24.67 11.98 10 49725 318 50555071
Gait disturbance 24.61 11.98 71 49664 149934 50405455
Memory impairment 24.58 11.98 25 49710 79335 50476054
Clostridium difficile colitis 24.49 11.98 54 49681 17688 50537701
Second primary malignancy 24.39 11.98 32 49703 6882 50548507
Chronic obstructive pulmonary disease 24.34 11.98 11 49724 53424 50501965
Suicidal ideation 24.31 11.98 12 49723 55373 50500016
Sleep disorder 24.26 11.98 13 49722 57270 50498119
Blister 24.16 11.98 29 49706 85389 50470000
Type II hypersensitivity 24.15 11.98 5 49730 10 50555379
Meningitis streptococcal 23.89 11.98 8 49727 146 50555243
Mobility decreased 23.85 11.98 26 49709 79922 50475467
Fluid retention 23.74 11.98 10 49725 50639 50504750
Human herpesvirus 6 infection 23.67 11.98 20 49715 2586 50552803
Asthma 23.53 11.98 32 49703 89305 50466084
Peritonitis 23.52 11.98 49 49686 15437 50539952
Multiple-drug resistance 23.29 11.98 22 49713 3292 50552097
Depilation 23.24 11.98 5 49730 13 50555376
Cholinergic syndrome 23.20 11.98 10 49725 372 50555017
Electrocardiogram QT prolonged 23.14 11.98 11 49724 51875 50503514
Neutropenic colitis 22.88 11.98 19 49716 2398 50552991
Ocular toxicity 22.78 11.98 11 49724 534 50554855
Gastrointestinal anastomotic leak 22.54 11.98 8 49727 175 50555214
Weight increased 22.44 11.98 112 49623 201779 50353610
K-ras gene mutation 22.24 11.98 5 49730 17 50555372
Arthralgia 22.16 11.98 301 49434 438401 50116988
Venoocclusive liver disease 22.09 11.98 24 49711 4237 50551152
Inferior vena cava stenosis 22.02 11.98 5 49730 18 50555371
Petechiae 21.90 11.98 42 49693 12470 50542919
Blood pressure fluctuation 21.72 11.98 81 49654 35742 50519647
Superior vena cava syndrome 21.61 11.98 11 49724 599 50554790
Folliculitis 21.40 11.98 6 49729 39219 50516170
Gastrointestinal stoma complication 21.19 11.98 15 49720 1495 50553894
Metastases to lymph nodes 20.99 11.98 30 49705 6994 50548395
Subileus 20.71 11.98 19 49716 2740 50552649
Portal vein dilatation 20.53 11.98 5 49730 26 50555363
Amnesia 20.37 11.98 8 49727 42252 50513137
Subacute cutaneous lupus erythematosus 20.12 11.98 17 49718 2198 50553191
Hip arthroplasty 20.02 11.98 3 49732 30426 50524963
Deep vein thrombosis 20.01 11.98 132 49603 73172 50482217
Abortion spontaneous 19.98 11.98 8 49727 41764 50513625
Cutaneous tuberculosis 19.86 11.98 7 49728 150 50555239
Vitiligo 19.84 11.98 13 49722 1141 50554248
Venous thrombosis limb 19.57 11.98 18 49717 2604 50552785
Soft tissue necrosis 19.51 11.98 9 49726 394 50554995
Large intestine perforation 19.50 11.98 30 49705 7464 50547925
Occult blood 19.31 11.98 13 49722 1194 50554195
Maternal exposure during pregnancy 19.30 11.98 86 49649 159692 50395697
Red cell fragmentation syndrome 19.15 11.98 5 49730 36 50555353
Pelvic fluid collection 19.03 11.98 11 49724 772 50554617
Hypertrichosis 18.91 11.98 12 49723 997 50554392
Overdose 18.80 11.98 44 49691 99683 50455706
Peripheral sensorimotor neuropathy 18.79 11.98 13 49722 1249 50554140
Haemoglobin increased 18.75 11.98 19 49716 3096 50552293
Adverse drug reaction 18.74 11.98 16 49719 55206 50500183
Varices oesophageal 18.62 11.98 18 49717 2771 50552618
Exposure during pregnancy 18.61 11.98 59 49676 120956 50434433
Ovarian fibroma 18.59 11.98 6 49729 97 50555292
Impaired healing 18.38 11.98 25 49710 69761 50485628
Joint noise 18.24 11.98 20 49715 3567 50551822
Gastric varices haemorrhage 18.21 11.98 6 49729 104 50555285
Endometrial dysplasia 18.17 11.98 4 49731 12 50555377
Feeling abnormal 18.05 11.98 63 49672 125429 50429960
Encephalopathy 17.82 11.98 73 49662 33638 50521751
Acute promyelocytic leukaemia 17.79 11.98 11 49724 873 50554516
Rash maculo-papular 17.64 11.98 62 49673 26579 50528810
Headache 17.60 11.98 372 49363 506163 50049226
Hypocapnia 17.54 11.98 8 49727 341 50555048
Portal shunt 17.49 11.98 4 49731 15 50555374
Haemolytic uraemic syndrome 17.46 11.98 16 49719 2303 50553086
Acute kidney injury 17.46 11.98 318 49417 227740 50327649
Proctalgia 17.41 11.98 23 49712 4980 50550409
Cytopenia 17.29 11.98 31 49704 8744 50546645
Coronary artery disease 17.27 11.98 4 49731 29722 50525667
Jugular vein thrombosis 17.25 11.98 17 49718 2679 50552710
Oesophageal fistula 17.22 11.98 6 49729 124 50555265
Administration site extravasation 17.18 11.98 10 49725 711 50554678
Tumour necrosis 17.01 11.98 10 49725 724 50554665
Productive cough 17.01 11.98 16 49719 52678 50502711
Migraine 16.93 11.98 30 49705 75250 50480139
Cardiomyopathy 16.71 11.98 43 49692 15543 50539846
Intentional product misuse 16.53 11.98 13 49722 46721 50508668
Cardiac arrest 16.51 11.98 36 49699 83615 50471774
Confusional state 16.45 11.98 111 49624 185817 50369572
Product use in unapproved indication 16.36 11.98 180 49555 115639 50439750
Hemiparesis 16.27 11.98 50 49685 19998 50535391
Portal vein thrombosis 16.15 11.98 15 49720 2197 50553192
Nodular regenerative hyperplasia 16.12 11.98 7 49728 265 50555124
Unevaluable event 16.06 11.98 13 49722 46053 50509336
Pruritus 15.99 11.98 190 49545 283378 50272011
Liver abscess 15.94 11.98 16 49719 2577 50552812
Small intestinal obstruction 15.87 11.98 43 49692 16025 50539364
Acquired gene mutation 15.87 11.98 10 49725 821 50554568
Rotator cuff syndrome 15.78 11.98 35 49700 11509 50543880
Paraesthesia 15.69 11.98 184 49551 120059 50435330
Toxic encephalopathy 15.67 11.98 23 49712 5492 50549897
Colitis 15.53 11.98 77 49658 38452 50516937
Depressed mood 15.50 11.98 7 49728 34016 50521373
Knee arthroplasty 15.38 11.98 8 49727 35838 50519551
Pneumothorax spontaneous 15.37 11.98 9 49726 647 50554742
Pneumothorax 15.34 11.98 39 49696 13995 50541394
Disease recurrence 15.30 11.98 49 49686 20032 50535357
Hallucination 15.26 11.98 14 49721 46643 50508746
Product intolerance 15.17 11.98 4 49731 30 50555359
No adverse event 15.15 11.98 7 49728 33571 50521818
Dysphagia 15.15 11.98 129 49606 77389 50478000
Throat tightness 15.11 11.98 50 49685 20797 50534592
Balance disorder 15.10 11.98 29 49706 70561 50484828
Pelvic abscess 15.08 11.98 12 49723 1426 50553963
Mouth ulceration 15.06 11.98 61 49674 27963 50527426
Somnolence 15.00 11.98 90 49645 154895 50400494
Asthenia 14.99 11.98 415 49320 318627 50236762
Plasma cell myeloma 14.98 11.98 6 49729 31316 50524073
Overgrowth fungal 14.95 11.98 5 49730 91 50555298
Treatment failure 14.92 11.98 77 49658 137560 50417829
Pneumonia 14.91 11.98 272 49463 378129 50177260
Hepatitis toxic 14.84 11.98 16 49719 2800 50552589
Optic nerve disorder 14.84 11.98 9 49726 690 50554699
Gait inability 14.82 11.98 9 49726 37018 50518371
Hypertransaminasaemia 14.78 11.98 18 49717 3593 50551796
Hepatic vein stenosis 14.73 11.98 4 49731 34 50555355
Cardiomyopathy acute 14.68 11.98 6 49729 195 50555194
Benign hydatidiform mole 14.55 11.98 5 49730 99 50555290
Acute myeloid leukaemia 14.55 11.98 40 49695 15034 50540355
Rhinocerebral mucormycosis 14.51 11.98 6 49729 201 50555188
Cachexia 14.49 11.98 20 49715 4513 50550876
Periportal sinus dilatation 14.49 11.98 3 49732 6 50555383
Accessory spleen 14.49 11.98 3 49732 6 50555383
Optic disc hyperaemia 14.49 11.98 3 49732 6 50555383
Mixed adenoneuroendocrine carcinoma 14.49 11.98 3 49732 6 50555383
Sedation 14.42 11.98 6 49729 30604 50524785
Myalgia 14.36 11.98 68 49667 124251 50431138
Irritability 14.34 11.98 5 49730 28421 50526968
Psychiatric decompensation 14.28 11.98 11 49724 1247 50554142
Tumour perforation 14.23 11.98 5 49730 106 50555283
Hyperbilirubinaemia 14.21 11.98 30 49705 9540 50545849
Psoriasis 14.19 11.98 29 49706 68971 50486418
Tumour rupture 14.19 11.98 5 49730 107 50555282
Upper respiratory tract infection 14.16 11.98 27 49708 65871 50489518
Tubular breast carcinoma 13.98 11.98 4 49731 42 50555347
Intracranial pressure increased 13.96 11.98 19 49716 4233 50551156
Muscle atrophy 13.86 11.98 23 49712 6098 50549291
Hepatic steatosis 13.84 11.98 54 49681 24330 50531059
Colon cancer metastatic 13.83 11.98 10 49725 1030 50554359
Rectal perforation 13.80 11.98 7 49728 378 50555011
Anxiety 13.80 11.98 110 49625 177496 50377893
Hemianaesthesia 13.72 11.98 7 49728 383 50555006
Acute lymphocytic leukaemia recurrent 13.67 11.98 13 49722 1962 50553427
Vaginal infection 13.55 11.98 23 49712 6213 50549176
Escherichia bacteraemia 13.52 11.98 16 49719 3100 50552289
Peripheral nerve injury 13.52 11.98 7 49728 395 50554994
Colon cancer recurrent 13.49 11.98 4 49731 48 50555341
Vaginal fistula 13.47 11.98 7 49728 398 50554991
Hepatic failure 13.36 11.98 65 49670 32218 50523171
Bradycardia 13.32 11.98 27 49708 64399 50490990
Agitation 13.19 11.98 20 49715 53364 50502025
Loss of personal independence in daily activities 13.13 11.98 31 49704 70019 50485370
Reticulocytosis 13.10 11.98 5 49730 135 50555254
Eczema asteatotic 13.08 11.98 6 49729 259 50555130
Metastases to peritoneum 13.05 11.98 15 49720 2818 50552571
COVID-19 13.02 11.98 16 49719 46646 50508743
Aortitis 13.02 11.98 9 49726 863 50554526
Chronic kidney disease 12.92 11.98 12 49723 39759 50515630
Anaemia of malignant disease 12.89 11.98 7 49728 435 50554954
Visual acuity reduced transiently 12.80 11.98 5 49730 144 50555245
Loss of consciousness 12.70 11.98 56 49679 104297 50451092
Metastases to bone marrow 12.69 11.98 6 49729 278 50555111
Enterocolitis 12.69 11.98 23 49712 6544 50548845
Granulomatous lymphadenitis 12.64 11.98 5 49730 149 50555240
Ovarian cystectomy 12.64 11.98 5 49730 149 50555240
Tubal rupture 12.59 11.98 3 49732 14 50555375
Hypocalcaemia 12.57 11.98 56 49679 26760 50528629
Psychotic disorder 12.54 11.98 3 49732 21809 50533580
Condition aggravated 12.50 11.98 211 49524 296847 50258542
Neuroendocrine carcinoma of the skin 12.46 11.98 7 49728 465 50554924
Drug resistance 12.41 11.98 44 49691 18945 50536444
Finger deformity 12.40 11.98 21 49714 5661 50549728
Gastrointestinal necrosis 12.38 11.98 14 49721 2584 50552805
Post procedural diarrhoea 12.36 11.98 5 49730 158 50555231
Bone pain 12.35 11.98 17 49718 47212 50508177
Pharyngotonsillitis 12.34 11.98 5 49730 159 50555230
Blood glucose increased 12.25 11.98 33 49702 71291 50484098
Drug eruption 12.17 11.98 4 49731 23602 50531787
Wheezing 12.00 11.98 27 49708 62020 50493369

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neutropenia 928.21 12.79 1189 54644 130522 29388172
Neuropathy peripheral 538.09 12.79 666 55167 70361 29448333
Skin toxicity 525.19 12.79 215 55618 3556 29515138
Diarrhoea 461.38 12.79 1523 54310 331175 29187519
Mucosal inflammation 378.66 12.79 377 55456 31218 29487476
Neurotoxicity 337.92 12.79 254 55579 14359 29504335
Dermatitis acneiform 330.20 12.79 175 55658 5316 29513378
Disease progression 323.22 12.79 565 55268 81351 29437343
Thrombocytopenia 297.85 12.79 732 55101 134091 29384603
Stomatitis 286.98 12.79 352 55481 36761 29481933
Palmar-plantar erythrodysaesthesia syndrome 281.60 12.79 229 55604 14530 29504164
Metastases to liver 262.87 12.79 201 55632 11655 29507039
Polyneuropathy 220.18 12.79 183 55650 11969 29506725
Arteriospasm coronary 210.73 12.79 101 55732 2464 29516230
Gastrointestinal toxicity 160.29 12.79 79 55754 2052 29516642
Proteinuria 157.57 12.79 171 55662 15633 29503061
Skin reaction 149.43 12.79 97 55736 4320 29514374
Completed suicide 147.98 12.79 5 55828 90241 29428453
Febrile neutropenia 145.37 12.79 504 55329 111736 29406958
Leukopenia 143.63 12.79 320 55513 54883 29463811
Paronychia 130.79 12.79 77 55756 2876 29515818
Pyrexia 119.17 12.79 938 54895 286684 29232010
Product dose omission issue 118.03 12.79 20 55813 96363 29422331
Portal hypertension 116.56 12.79 76 55757 3410 29515284
Decreased appetite 113.91 12.79 559 55274 144783 29373911
Vomiting 112.59 12.79 735 55098 211525 29307169
Haematotoxicity 111.30 12.79 96 55737 6603 29512091
Bone marrow failure 110.15 12.79 191 55642 27258 29491436
Nausea 106.17 12.79 918 54915 288337 29230357
Cardiotoxicity 101.99 12.79 79 55754 4665 29514029
Metastases to lung 101.95 12.79 98 55735 7757 29510937
Carcinoembryonic antigen increased 98.68 12.79 39 55794 585 29518109
General physical health deterioration 97.11 12.79 418 55415 102439 29416255
Drug abuse 96.86 12.79 17 55816 79866 29438828
Peripheral sensory neuropathy 96.42 12.79 84 55749 5855 29512839
Cardiac failure congestive 95.74 12.79 15 55818 76566 29442128
Alopecia 94.44 12.79 146 55687 18938 29499756
Rash pustular 94.13 12.79 75 55758 4616 29514078
Hyperammonaemia 93.76 12.79 81 55752 5582 29513112
Drug ineffective 91.44 12.79 365 55468 362805 29155889
Chills 88.57 12.79 316 55517 70984 29447710
Intestinal obstruction 87.82 12.79 142 55691 19135 29499559
Therapy partial responder 87.37 12.79 75 55758 5124 29513570
Abdominal pain 87.02 12.79 493 55340 134864 29383830
Myelosuppression 83.34 12.79 109 55724 12118 29506576
Rhabdomyolysis 78.10 12.79 11 55822 60797 29457897
Neoplasm progression 77.93 12.79 132 55701 18480 29500214
Myalgia 77.19 12.79 22 55811 73997 29444697
Hyperammonaemic encephalopathy 75.52 12.79 47 55786 1943 29516751
Drug interaction 75.26 12.79 163 55670 197222 29321472
Pulmonary embolism 74.47 12.79 314 55519 76220 29442474
Focal nodular hyperplasia 73.34 12.79 22 55811 133 29518561
Gastrointestinal perforation 72.70 12.79 57 55776 3426 29515268
Fall 67.78 12.79 146 55687 177032 29341662
Interstitial lung disease 65.10 12.79 248 55585 57470 29461224
Malignant neoplasm progression 63.48 12.79 292 55541 73567 29445127
Myocardial infarction 63.19 12.79 69 55764 110227 29408467
Enteritis 61.67 12.79 70 55763 6721 29511973
Ascites 60.54 12.79 179 55654 36440 29482254
Colorectal cancer metastatic 58.28 12.79 26 55807 535 29518159
Pneumonia 57.39 12.79 362 55471 319810 29198884
Death 56.70 12.79 396 55437 341688 29177006
Anxiety 56.36 12.79 47 55786 85318 29433376
Insomnia 56.02 12.79 51 55782 88710 29429984
Metastases to peritoneum 55.42 12.79 35 55798 1485 29517209
Febrile bone marrow aplasia 53.97 12.79 68 55765 7283 29511411
Ileus 53.61 12.79 97 55736 14305 29504389
Bradycardia 52.87 12.79 29 55804 65600 29453094
Small intestinal obstruction 52.52 12.79 91 55742 12970 29505724
Paraesthesia 52.41 12.79 221 55612 53624 29465070
Plasma cell myeloma 51.91 12.79 5 55828 37110 29481584
Somnolence 51.39 12.79 61 55772 93894 29424800
Transdifferentiation of neoplasm 49.91 12.79 14 55819 64 29518630
Hiccups 49.89 12.79 72 55761 8781 29509913
Asthma 48.85 12.79 4 55829 33845 29484849
Headache 48.75 12.79 167 55666 173840 29344854
Arthralgia 48.56 12.79 121 55712 139496 29379198
Hypomagnesaemia 48.47 12.79 104 55729 17364 29501330
Subileus 47.66 12.79 41 55792 2809 29515885
Dehydration 47.63 12.79 375 55458 114373 29404321
Anastomotic leak 47.53 12.79 23 55810 573 29518121
Drug clearance decreased 47.37 12.79 31 55802 1399 29517295
Cholangitis 46.48 12.79 64 55769 7473 29511221
Influenza 46.41 12.79 11 55822 41870 29476824
Metastases to lymph nodes 46.33 12.79 47 55786 3970 29514724
Coronary artery disease 46.30 12.79 13 55820 44177 29474517
Subclavian vein thrombosis 45.68 12.79 25 55808 810 29517884
Device related infection 45.60 12.79 95 55738 15541 29503153
Hospitalisation 45.53 12.79 15 55818 45973 29472721
Intentional overdose 44.97 12.79 9 55824 38519 29480175
Weight increased 44.96 12.79 47 55786 76620 29442074
Proteus infection 44.58 12.79 25 55808 850 29517844
Febrile infection 44.45 12.79 34 55799 1970 29516724
Aggression 44.31 12.79 7 55826 35534 29483160
Conjunctivitis 43.55 12.79 64 55769 7934 29510760
Tumour necrosis 43.52 12.79 27 55806 1110 29517584
Blood glucose increased 43.40 12.79 29 55804 58955 29459739
Dizziness 43.01 12.79 198 55635 189486 29329208
Intravascular haemolysis 42.50 12.79 19 55814 393 29518301
Anastomotic complication 42.20 12.79 18 55815 331 29518363
Feeling abnormal 41.10 12.79 26 55807 54419 29464275
Peripheral swelling 40.95 12.79 36 55797 63703 29454991
Ileal perforation 40.84 12.79 22 55811 690 29518004
Epistaxis 40.45 12.79 199 55634 51505 29467189
Nicotinic acid deficiency 40.36 12.79 12 55821 70 29518624
Leukoencephalopathy 39.71 12.79 42 55791 3725 29514969
Chronic obstructive pulmonary disease 39.43 12.79 14 55819 40941 29477753
Injection site pain 39.10 12.79 7 55826 32439 29486255
Anal haemorrhage 38.57 12.79 31 55802 1931 29516763
Erythema 37.58 12.79 258 55575 75348 29443346
Carbohydrate antigen 19-9 increased 37.45 12.79 14 55819 179 29518515
Pain in extremity 36.61 12.79 98 55735 110335 29408359
Sinusitis 36.18 12.79 10 55823 34340 29484354
Pelvic abscess 36.18 12.79 22 55811 872 29517822
Administration site extravasation 35.94 12.79 18 55815 484 29518210
Suicidal ideation 34.93 12.79 11 55822 34705 29483989
Recall phenomenon 34.86 12.79 18 55815 517 29518177
Unevaluable event 34.78 12.79 7 55826 29844 29488850
Intestinal perforation 34.70 12.79 58 55775 8028 29510666
Type II hypersensitivity 34.56 12.79 9 55824 29 29518665
Depression 34.32 12.79 68 55765 85079 29433615
Hypersensitivity 34.10 12.79 193 55640 52710 29465984
Rectal tenesmus 34.07 12.79 19 55814 639 29518055
Foetal disorder 33.58 12.79 20 55813 763 29517931
Vena cava thrombosis 33.56 12.79 22 55811 996 29517698
Colon cancer recurrent 33.38 12.79 11 55822 94 29518600
Tumour lysis syndrome 33.30 12.79 78 55755 13806 29504888
Intentional product misuse 33.11 12.79 12 55821 34649 29484045
Hallucination 32.86 12.79 22 55811 44690 29474004
Contusion 32.85 12.79 9 55824 31086 29487608
Pneumatosis intestinalis 32.82 12.79 35 55798 3134 29515560
Necrotising fasciitis 32.81 12.79 36 55797 3329 29515365
Anal fissure 32.65 12.79 33 55800 2775 29515919
Asthenia 32.63 12.79 579 55254 214671 29304023
Wheezing 32.62 12.79 11 55822 33229 29485465
Small intestinal perforation 32.54 12.79 26 55807 1606 29517088
Neoplasm recurrence 32.16 12.79 28 55805 1949 29516745
Treatment noncompliance 32.01 12.79 4 55829 24223 29494471
Cellulitis 31.79 12.79 24 55809 45816 29472878
Colitis 31.75 12.79 130 55703 31118 29487576
Muscle spasms 31.73 12.79 46 55787 65036 29453658
Hyperbilirubinaemia 31.65 12.79 80 55753 14854 29503840
Adverse drug reaction 31.65 12.79 4 55829 24016 29494678
Jugular vein thrombosis 31.59 12.79 24 55809 1376 29517318
Induration 31.51 12.79 20 55813 856 29517838
Hypoglycaemia 31.42 12.79 27 55806 48319 29470375
Psoriasis 31.05 12.79 11 55822 32216 29486478
Peritonitis 30.99 12.79 79 55754 14745 29503949
Colitis microscopic 30.78 12.79 26 55807 1737 29516957
Proctalgia 30.74 12.79 39 55794 4206 29514488
Anaemia of malignant disease 30.73 12.79 15 55818 381 29518313
Cholinergic syndrome 30.66 12.79 16 55817 470 29518224
Prothrombin level decreased 30.41 12.79 21 55812 1037 29517657
Blood creatine phosphokinase increased 29.87 12.79 20 55813 40624 29478070
Abdominal pain lower 29.41 12.79 56 55777 8582 29510112
Acute coronary syndrome 29.29 12.79 69 55764 12256 29506438
Electrocardiogram ST segment elevation 29.00 12.79 39 55794 4453 29514241
Catheter site thrombosis 28.99 12.79 8 55825 34 29518660
Neutropenia neonatal 28.75 12.79 17 55816 640 29518054
Overdose 28.64 12.79 68 55765 79751 29438943
Hypoalbuminaemia 28.18 12.79 61 55772 10244 29508450
Toxic erythema of chemotherapy 28.16 12.79 9 55824 69 29518625
Peripheral sensorimotor neuropathy 27.56 12.79 22 55811 1357 29517337
Venoocclusive liver disease 27.55 12.79 48 55785 6869 29511825
Evans syndrome 27.21 12.79 12 55821 240 29518454
Enterovesical fistula 27.14 12.79 16 55817 599 29518095
Sarcoidosis 27.06 12.79 29 55804 2611 29516083
Confusional state 26.90 12.79 137 55696 127740 29390954
Perforation 26.74 12.79 11 55822 184 29518510
Large intestine perforation 26.68 12.79 49 55784 7307 29511387
Portal vein thrombosis 26.53 12.79 32 55801 3277 29515417
Perihepatic abscess 26.51 12.79 9 55824 85 29518609
Fluid retention 26.47 12.79 6 55827 23554 29495140
Anaemia 26.45 12.79 529 55304 200422 29318272
Koebner phenomenon 26.44 12.79 8 55825 50 29518644
Off label use 25.97 12.79 747 55086 300053 29218641
Enterocutaneous fistula 25.94 12.79 17 55816 769 29517925
Hypokalaemia 25.94 12.79 173 55660 50030 29468664
Cerebral vasoconstriction 25.65 12.79 11 55822 205 29518489
Injury 25.52 12.79 3 55830 19043 29499651
Memory impairment 25.41 12.79 19 55814 36451 29482243
Pelvic fluid collection 25.21 12.79 9 55824 100 29518594
Wrong technique in product usage process 25.13 12.79 14 55819 31414 29487280
Disturbance in attention 25.00 12.79 5 55828 21419 29497275
Electrocardiogram QT prolonged 24.96 12.79 19 55814 36118 29482576
Stoma site haemorrhage 24.87 12.79 16 55817 701 29517993
Clostridial infection 24.87 12.79 31 55802 3284 29515410
Rectal perforation 24.66 12.79 13 55820 390 29518304
Oesophagitis 24.36 12.79 63 55770 11860 29506834
Perioral dermatitis 24.22 12.79 9 55824 113 29518581
Stoma site pain 24.21 12.79 14 55819 505 29518189
Abdominal discomfort 24.20 12.79 33 55800 47870 29470824
Interventricular septum rupture 24.16 12.79 6 55827 15 29518679
Nail disorder 24.12 12.79 23 55810 1801 29516893
Nephrotic syndrome 24.03 12.79 43 55790 6285 29512409
Peritoneal neoplasm 23.97 12.79 7 55826 38 29518656
Splenomegaly 23.95 12.79 67 55766 13212 29505482
Superior vena cava syndrome 23.67 12.79 14 55819 527 29518167
Product prescribing error 23.67 12.79 3 55830 17973 29500721
Device related thrombosis 23.39 12.79 17 55816 911 29517783
Mucosal toxicity 23.19 12.79 10 55823 189 29518505
Anal erythema 23.07 12.79 8 55825 81 29518613
Acute abdomen 23.05 12.79 22 55811 1725 29516969
Pneumoperitoneum 23.05 12.79 21 55812 1552 29517142
Sleep apnoea syndrome 23.02 12.79 3 55830 17596 29501098
Liver function test abnormal 22.95 12.79 13 55820 28905 29489789
Cardiac disorder 22.80 12.79 22 55811 37241 29481453
Organising pneumonia 22.73 12.79 37 55796 5011 29513683
Influenza like illness 22.49 12.79 9 55824 24461 29494233
Acne 22.33 12.79 52 55781 9168 29509526
Oesophageal haemorrhage 22.21 12.79 18 55815 1135 29517559
Rheumatoid arthritis 22.08 12.79 17 55816 32135 29486559
Cerebrovascular accident 22.05 12.79 73 55760 76838 29441856
Colon cancer metastatic 22.03 12.79 20 55813 1471 29517223
Perforation bile duct 22.03 12.79 6 55827 24 29518670
Pulmonary oedema 22.03 12.79 29 55804 42706 29475988
Pulmonary artery thrombosis 22.02 12.79 14 55819 601 29518093
International normalised ratio increased 21.98 12.79 31 55802 44341 29474353
Incorrect dose administered 21.95 12.79 18 55815 32966 29485728
Trichomegaly 21.84 12.79 6 55827 25 29518669
Seizure 21.78 12.79 96 55737 93027 29425667
Intentional product use issue 21.74 12.79 29 55804 42469 29476225
Product use issue 21.67 12.79 40 55793 51404 29467290
Mouth ulceration 21.45 12.79 55 55778 10300 29508394
Aplasia 21.38 12.79 32 55801 4031 29514663
Varices oesophageal 21.36 12.79 28 55805 3118 29515576
Anastomotic fistula 21.22 12.79 7 55826 60 29518634
Haematopoietic stem cell mobilisation 21.17 12.79 9 55824 164 29518530
Ischiorectal hernia 20.90 12.79 5 55828 10 29518684
Pulmonary infarction 20.65 12.79 17 55816 1096 29517598
Hepatectomy 20.45 12.79 7 55826 68 29518626
Sedation 20.44 12.79 4 55829 17401 29501293
B-cell small lymphocytic lymphoma 20.42 12.79 8 55825 117 29518577
Dyspnoea 20.37 12.79 466 55367 326266 29192428
Cholecystitis chronic 20.36 12.79 15 55818 821 29517873
Venous thrombosis 20.26 12.79 27 55806 3055 29515639
ECG signs of myocardial ischaemia 20.23 12.79 9 55824 184 29518510
Embolism 20.22 12.79 42 55791 6854 29511840
Dysaesthesia 20.10 12.79 22 55811 2028 29516666
Liver abscess 20.07 12.79 28 55805 3310 29515384
Cranial nerve disorder 20.03 12.79 12 55821 463 29518231
Circulatory collapse 20.02 12.79 79 55754 18594 29500100
Eyelash changes 19.99 12.79 5 55828 13 29518681
Respiratory arrest 19.96 12.79 12 55821 25821 29492873
Sepsis 19.89 12.79 379 55454 142303 29376391
Oral pain 19.87 12.79 50 55783 9257 29509437
Acute motor-sensory axonal neuropathy 19.83 12.79 8 55825 127 29518567
Productive cough 19.66 12.79 18 55815 31241 29487453
Dysphonia 19.61 12.79 80 55753 19116 29499578
Allodynia 19.60 12.79 13 55820 600 29518094
Hepatitis B surface antigen positive 19.49 12.79 8 55825 133 29518561
Visceral venous thrombosis 19.47 12.79 5 55828 15 29518679
K-ras gene mutation 19.23 12.79 5 55828 16 29518678
Performance status decreased 19.11 12.79 29 55804 3698 29514996
Haematoma 19.06 12.79 10 55823 23202 29495492
Catheter site extravasation 19.05 12.79 7 55826 85 29518609
Arthritis 18.80 12.79 12 55821 25007 29493687
Oesophagobronchial fistula 18.61 12.79 8 55825 150 29518544
Rectal abscess 18.60 12.79 15 55818 939 29517755
Pseudocirrhosis 18.56 12.79 5 55828 19 29518675
Mobility decreased 18.52 12.79 13 55820 25767 29492927
Chronic kidney disease 18.48 12.79 25 55808 36391 29482303
Haemolytic anaemia 18.46 12.79 49 55784 9370 29509324
Klebsiella infection 18.40 12.79 42 55791 7307 29511387
Neutrophil count decreased 18.37 12.79 143 55690 43424 29475270
Bacterial colitis 18.34 12.79 6 55827 50 29518644
Angioedema 18.21 12.79 20 55813 31895 29486799
Agitation 18.16 12.79 44 55789 51260 29467434
Soft tissue swelling 18.16 12.79 10 55823 328 29518366
Neurosarcoidosis 18.05 12.79 8 55825 162 29518532
Joint swelling 18.02 12.79 42 55791 49588 29469106
Contraindicated product administered 18.00 12.79 6 55827 18260 29500434
Portal venous gas 17.99 12.79 10 55823 334 29518360
Streptococcal bacteraemia 17.90 12.79 19 55814 1692 29517002
Electromyogram abnormal 17.84 12.79 6 55827 55 29518639
Proctitis 17.82 12.79 21 55812 2098 29516596
Non-cirrhotic portal hypertension 17.80 12.79 9 55824 247 29518447
Colorectal cancer recurrent 17.80 12.79 5 55828 23 29518671
Organic brain syndrome 17.64 12.79 9 55824 252 29518442
Candida infection 17.62 12.79 66 55767 15159 29503535
Cerebral haemorrhage 17.60 12.79 20 55813 31406 29487288
Heart rate increased 17.55 12.79 29 55804 38909 29479785
Vocal cord paralysis 17.53 12.79 14 55819 864 29517830
Lung neoplasm malignant 17.51 12.79 3 55830 14354 29504340
Abnormal behaviour 17.51 12.79 11 55822 23116 29495578
Radiation interaction 17.46 12.79 5 55828 25 29518669
Pelvic inflammatory disease 17.44 12.79 4 55829 6 29518688
Hypertension 17.37 12.79 313 55520 116301 29402393
Fatigue 17.36 12.79 747 55086 316074 29202620
Deep vein thrombosis 17.28 12.79 175 55658 57224 29461470
Perineal disorder 17.20 12.79 6 55827 62 29518632
Malignant ascites 17.14 12.79 10 55823 367 29518327
Toxicity to various agents 17.13 12.79 228 55605 173433 29345261
Fistula 17.11 12.79 33 55800 5106 29513588
Brief psychotic disorder with marked stressors 16.92 12.79 8 55825 189 29518505
Posterior reversible encephalopathy syndrome 16.89 12.79 46 55787 8930 29509764
Hypervolaemia 16.88 12.79 6 55827 17539 29501155
Renal disorder 16.76 12.79 11 55822 22584 29496110
Emotional distress 16.73 12.79 3 55830 13892 29504802
Cardiac arrest 16.70 12.79 94 55739 85497 29433197
Cachexia 16.70 12.79 37 55796 6312 29512382
Skin fissures 16.67 12.79 28 55805 3891 29514803
Metastasis 16.63 12.79 26 55807 3403 29515291
Intestinal strangulation 16.56 12.79 5 55828 31 29518663
Thrombotic thrombocytopenic purpura 16.52 12.79 25 55808 3181 29515513
Neck pain 16.51 12.79 10 55823 21437 29497257
Cataract 16.45 12.79 11 55822 22367 29496327
Hepatic cancer recurrent 16.40 12.79 9 55824 293 29518401
Bronchitis 16.12 12.79 28 55805 36840 29481854
Tumour marker increased 16.11 12.79 11 55822 533 29518161
Tumour fistulisation 16.11 12.79 4 55829 10 29518684
Multiple organ dysfunction syndrome 16.03 12.79 63 55770 63053 29455641
Change of bowel habit 16.01 12.79 14 55819 980 29517714
Astringent therapy 15.83 12.79 4 55829 11 29518683
Faeces discoloured 15.82 12.79 3 55830 13348 29505346
Duodenal perforation 15.81 12.79 15 55818 1167 29517527
Hypersplenism 15.81 12.79 9 55824 315 29518379
Upper gastrointestinal haemorrhage 15.81 12.79 11 55822 21903 29496791
Onychoclasis 15.80 12.79 18 55815 1735 29516959
Haemorrhage intracranial 15.75 12.79 4 55829 14538 29504156
Temperature difference of extremities 15.57 12.79 4 55829 12 29518682
Acinetobacter sepsis 15.57 12.79 5 55828 39 29518655
Portal shunt 15.57 12.79 5 55828 39 29518655
Road traffic accident 15.53 12.79 5 55828 15556 29503138
Retinitis viral 15.43 12.79 6 55827 86 29518608
Balance disorder 15.34 12.79 28 55805 36142 29482552
Retroperitoneal abscess 15.18 12.79 7 55826 156 29518538
Gastrointestinal haemorrhage 15.17 12.79 88 55745 79445 29439249
Bladder hypertrophy 15.09 12.79 11 55822 592 29518102
Gastrointestinal anastomotic leak 14.91 12.79 9 55824 352 29518342
Urticaria 14.90 12.79 53 55780 54607 29464087
Irritability 14.85 12.79 12 55821 22140 29496554
Medication error 14.84 12.79 11 55822 21200 29497494
Injection site erythema 14.81 12.79 4 55829 13952 29504742
Drug clearance increased 14.77 12.79 6 55827 97 29518597
Prostatic calcification 14.72 12.79 6 55827 98 29518596
Laryngospasm 14.71 12.79 15 55818 1275 29517419
Paraesthesia mucosal 14.69 12.79 4 55829 16 29518678
Limbic encephalitis 14.66 12.79 9 55824 363 29518331
Rectal adenocarcinoma 14.65 12.79 12 55821 768 29517926
Peritoneal disorder 14.59 12.79 8 55825 260 29518434
Crystal nephropathy 14.46 12.79 9 55824 372 29518322
Immune thrombocytopenia 14.46 12.79 40 55793 7837 29510857
Metastases to pelvis 14.40 12.79 8 55825 267 29518427
Tremor 14.22 12.79 81 55752 73457 29445237
Ocular toxicity 14.19 12.79 7 55826 182 29518512
Ventricular tachycardia 14.19 12.79 13 55820 22561 29496133
Rectal cancer recurrent 14.14 12.79 4 55829 19 29518675
Bacteriuria 14.08 12.79 8 55825 279 29518415
Hepatic lesion 14.06 12.79 23 55810 3127 29515567
Therapy non-responder 13.95 12.79 23 55810 30888 29487806
Renal impairment 13.95 12.79 93 55740 81240 29437454
Nodular regenerative hyperplasia 13.87 12.79 11 55822 672 29518022
Blood pressure decreased 13.84 12.79 42 55791 45435 29473259
Iatrogenic infection 13.81 12.79 5 55828 58 29518636
VIth nerve disorder 13.81 12.79 4 55829 21 29518673
Psychotic disorder 13.67 12.79 11 55822 20343 29498351
Tracheal inflammation 13.66 12.79 5 55828 60 29518634
Electric shock 13.65 12.79 6 55827 119 29518575
Abscess 13.61 12.79 45 55788 9717 29508977
Diffuse alveolar damage 13.59 12.79 18 55815 2025 29516669
Obstruction gastric 13.51 12.79 12 55821 858 29517836
Chemotherapeutic drug level increased 13.50 12.79 7 55826 203 29518491
Adenocarcinoma 13.50 12.79 16 55817 1609 29517085
Oesophageal irritation 13.44 12.79 5 55828 63 29518631
Intestinal mucosal hypertrophy 13.44 12.79 5 55828 63 29518631
Pulmonary toxicity 13.43 12.79 29 55804 4861 29513833
Peritoneal adhesions 13.43 12.79 6 55827 124 29518570
Laboratory test interference 13.41 12.79 9 55824 424 29518270
Aphthous ulcer 13.39 12.79 26 55807 4042 29514652
Jaundice 13.39 12.79 98 55735 29198 29489496
Oedema 13.34 12.79 36 55797 40447 29478247
Dyskinesia 13.28 12.79 11 55822 20050 29498644
Colorectal cancer 13.28 12.79 17 55816 1850 29516844
Neuropathic muscular atrophy 13.22 12.79 4 55829 25 29518669
Pleural fistula 13.22 12.79 4 55829 25 29518669
Central pain syndrome 13.16 12.79 5 55828 67 29518627
Abdominal sepsis 13.14 12.79 12 55821 890 29517804
Disseminated intravascular coagulation 12.93 12.79 73 55760 19907 29498787
Lip dry 12.86 12.79 13 55820 1093 29517601
Gout 12.86 12.79 8 55825 16903 29501791
Splenic abscess 12.85 12.79 8 55825 331 29518363
Gastrooesophageal reflux disease 12.81 12.79 25 55808 31471 29487223

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neutropenia 1825.74 11.55 1992 92826 237632 64166282
Neuropathy peripheral 1134.06 11.55 1111 93707 116414 64287500
Neurotoxicity 735.79 11.55 474 94344 26930 64376984
Mucosal inflammation 704.71 11.55 645 94173 61939 64341975
Skin toxicity 695.12 11.55 287 94531 6315 64397599
Diarrhoea 663.85 11.55 2443 92375 720261 63683653
Disease progression 648.68 11.55 914 93904 140766 64263148
Thrombocytopenia 644.57 11.55 1168 93650 222633 64181281
Dermatitis acneiform 448.30 11.55 228 94590 8215 64395699
Polyneuropathy 370.85 11.55 275 94543 19619 64384295
Stomatitis 343.10 11.55 594 94224 109011 64294903
Febrile neutropenia 334.44 11.55 805 94013 186852 64217062
Palmar-plantar erythrodysaesthesia syndrome 331.91 11.55 301 94517 28518 64375396
Arteriospasm coronary 308.95 11.55 154 94664 5311 64398603
Leukopenia 306.86 11.55 541 94277 100701 64303213
Completed suicide 304.52 11.55 5 94813 224409 64179505
Haematotoxicity 295.07 11.55 202 94616 12694 64391220
Neoplasm progression 281.79 11.55 324 94494 40640 64363274
Metastases to liver 275.58 11.55 250 94568 23691 64380223
Proteinuria 257.27 11.55 257 94561 27466 64376448
Gastrointestinal toxicity 234.85 11.55 127 94691 5195 64398719
Bone marrow failure 216.96 11.55 308 94510 47644 64356270
Secondary immunodeficiency 194.16 11.55 90 94728 2634 64401280
Malignant neoplasm progression 175.43 11.55 460 94358 112411 64291503
Vomiting 173.39 11.55 1392 93426 549725 63854189
Portal hypertension 172.83 11.55 110 94708 6109 64397805
Myelosuppression 163.03 11.55 188 94630 23642 64380272
Pulmonary embolism 158.99 11.55 525 94293 145831 64258083
Enteritis 154.67 11.55 134 94684 11943 64391971
Focal nodular hyperplasia 152.28 11.55 51 94767 606 64403308
Product dose omission issue 149.34 11.55 50 94768 194697 64209217
Nausea 149.06 11.55 1785 93033 784015 63619899
Pyrexia 147.78 11.55 1358 93460 557286 63846628
Cardiotoxicity 145.95 11.55 121 94697 10153 64393761
Paronychia 144.52 11.55 100 94718 6392 64397522
Therapy partial responder 142.06 11.55 119 94699 10129 64393785
Hyperammonaemia 135.22 11.55 114 94704 9790 64394124
Metastases to lung 135.18 11.55 138 94680 15126 64388788
Peripheral sensory neuropathy 133.24 11.55 120 94698 11258 64392656
General physical health deterioration 130.80 11.55 621 94197 203804 64200110
Fall 129.67 11.55 261 94557 416565 63987349
Drug clearance decreased 128.26 11.55 67 94751 2552 64401362
Drug abuse 124.80 11.55 22 94796 132352 64271562
Peripheral swelling 122.76 11.55 78 94740 209075 64194839
Abdominal pain 121.23 11.55 830 93988 311545 64092369
Intestinal obstruction 113.82 11.55 197 94621 36089 64367825
Hyperammonaemic encephalopathy 110.83 11.55 71 94747 3987 64399927
Rash pustular 109.39 11.55 101 94717 9784 64394130
Posterior reversible encephalopathy syndrome 109.13 11.55 151 94667 22795 64381119
Carcinoembryonic antigen increased 106.51 11.55 53 94765 1820 64402094
Gastrointestinal perforation 105.61 11.55 77 94741 5347 64398567
Mycobacterium chelonae infection 102.75 11.55 54 94764 2083 64401831
Non-cirrhotic portal hypertension 100.91 11.55 33 94785 362 64403552
Anaemia 99.57 11.55 920 93898 377760 64026154
Colorectal cancer metastatic 98.55 11.55 41 94777 919 64402995
Intentional overdose 93.95 11.55 11 94807 89933 64313981
Swelling 93.65 11.55 60 94758 160158 64243756
Chills 93.62 11.55 425 94393 136839 64267075
Arthralgia 93.55 11.55 335 94483 441925 63961989
Systemic lupus erythematosus 93.52 11.55 5 94813 77607 64326307
Venoocclusive liver disease 93.17 11.55 93 94725 9922 64393992
Interstitial lung disease 92.47 11.55 335 94483 97397 64306517
Rhabdomyolysis 91.51 11.55 13 94805 91713 64312201
Arthropathy 91.06 11.55 32 94786 120935 64282979
Cholangitis 90.85 11.55 95 94723 10707 64393207
Insomnia 89.74 11.55 95 94723 197741 64206173
Joint swelling 89.50 11.55 111 94707 215271 64188643
Hypomagnesaemia 86.25 11.55 178 94640 37198 64366716
Pneumatosis intestinalis 85.77 11.55 67 94751 5162 64398752
Drug ineffective 84.39 11.55 810 94008 839437 63564477
Decreased appetite 83.48 11.55 702 94116 280587 64123327
Ileus 83.16 11.55 133 94685 22833 64381081
Epistaxis 80.97 11.55 322 94496 97809 64306105
Ascites 80.74 11.55 237 94581 61764 64342150
Leukoencephalopathy 80.63 11.55 73 94745 6894 64397020
Synovitis 78.47 11.55 24 94794 99066 64304848
Intestinal perforation 77.71 11.55 104 94714 15209 64388705
Splenomegaly 76.28 11.55 112 94706 17849 64386065
Headache 75.90 11.55 462 94356 529005 63874909
Skin reaction 75.47 11.55 92 94726 12260 64391654
Pain 75.23 11.55 491 94327 553020 63850894
Device related infection 74.40 11.55 149 94669 30477 64373437
Dizziness 73.98 11.55 353 94465 429810 63974104
Bacterial infection 72.49 11.55 131 94687 24819 64379095
Administration site extravasation 72.41 11.55 34 94784 1025 64402889
Cardiac failure congestive 72.15 11.55 52 94766 130528 64273386
Asthma 71.99 11.55 25 94793 95200 64308714
Nicotinic acid deficiency 71.18 11.55 20 94798 124 64403790
Myalgia 70.99 11.55 77 94741 158540 64245374
Anxiety 69.88 11.55 119 94699 202530 64201384
Anastomotic leak 69.11 11.55 32 94786 934 64402980
Tumour lysis syndrome 68.23 11.55 111 94707 19329 64384585
Weight increased 67.57 11.55 132 94686 213216 64190698
Subileus 67.35 11.55 57 94761 4920 64398994
Glossodynia 67.34 11.55 8 94810 64688 64339226
Pain in extremity 67.09 11.55 225 94593 302860 64101054
Dehydration 65.34 11.55 543 94275 216220 64187694
Depression 64.70 11.55 106 94712 183185 64220729
Somnolence 64.49 11.55 126 94692 203519 64200395
Human bocavirus infection 64.11 11.55 26 94792 545 64403369
Injection site pain 63.35 11.55 43 94775 111365 64292549
Injury 63.34 11.55 5 94813 55987 64347927
Myocardial infarction 63.23 11.55 91 94727 165730 64238184
Hypertension 63.11 11.55 620 94198 258641 64145273
Febrile bone marrow aplasia 62.64 11.55 80 94738 11175 64392739
Contusion 62.16 11.55 46 94772 113919 64289995
Intentional product misuse 60.03 11.55 16 94802 72279 64331635
Pseudomonal sepsis 59.48 11.55 54 94764 5118 64398796
Abdominal discomfort 59.30 11.55 111 94707 182211 64221703
Vena cava thrombosis 59.00 11.55 40 94778 2472 64401442
Hospitalisation 58.14 11.55 19 94799 75188 64328726
Pancytopenia 57.96 11.55 385 94433 142924 64260990
Parainfluenzae virus infection 57.47 11.55 51 94767 4692 64399222
Paraesthesia 57.21 11.55 366 94452 134156 64269758
Tumour necrosis 57.09 11.55 34 94784 1675 64402239
Bradycardia 55.59 11.55 55 94763 118164 64285750
Drug hypersensitivity 55.06 11.55 173 94645 237642 64166272
Hyperbilirubinaemia 54.94 11.55 106 94712 21099 64382815
Embolism 54.44 11.55 78 94740 12157 64391757
Sepsis 53.70 11.55 546 94272 229795 64174119
Small intestinal obstruction 52.90 11.55 111 94707 23462 64380452
Pelvic abscess 52.18 11.55 33 94785 1812 64402102
Hiccups 52.17 11.55 63 94755 8313 64395601
Diffuse alveolar damage 52.09 11.55 41 94777 3194 64400720
Hepatic enzyme increased 51.84 11.55 69 94749 129874 64274040
Sinusitis 50.92 11.55 85 94733 145843 64258071
Maternal exposure during pregnancy 50.63 11.55 40 94778 95844 64308070
Mucosal toxicity 50.46 11.55 21 94797 471 64403443
Neutrophil count decreased 50.36 11.55 236 94582 76960 64326954
Electrocardiogram QT prolonged 50.29 11.55 27 94791 79421 64324493
Chronic obstructive pulmonary disease 49.80 11.55 21 94797 71027 64332887
Crystal nephropathy 49.79 11.55 28 94790 1237 64402677
Contraindicated product administered 49.74 11.55 51 94767 107778 64296136
Transdifferentiation of neoplasm 49.39 11.55 14 94804 90 64403824
Suicidal ideation 49.39 11.55 18 94800 66524 64337390
Feeling abnormal 49.28 11.55 75 94743 133527 64270387
Mobility decreased 48.98 11.55 33 94785 85807 64318107
Wheezing 48.69 11.55 29 94789 80550 64323364
Metastases to lymph nodes 48.57 11.55 62 94756 8655 64395259
Overdose 48.56 11.55 101 94717 159465 64244449
Metastases to meninges 48.20 11.55 37 94781 2778 64401136
Abscess bacterial 47.66 11.55 23 94795 738 64403176
Memory impairment 47.48 11.55 34 94784 85648 64318266
Drug interaction 47.17 11.55 325 94493 361758 64042156
Neoplasm recurrence 46.89 11.55 41 94777 3698 64400216
Metastases to peritoneum 46.72 11.55 40 94778 3507 64400407
Steatohepatitis 46.27 11.55 23 94795 788 64403126
Peritonitis 46.21 11.55 109 94709 24914 64379000
Gene mutation 46.17 11.55 32 94786 2050 64401864
Off label use 45.99 11.55 1236 93582 631570 63772344
Lower respiratory tract infection 45.66 11.55 43 94775 94571 64309343
Colitis 45.57 11.55 189 94629 58485 64345429
Cholinergic syndrome 45.42 11.55 23 94795 820 64403094
Plasma cell myeloma 44.87 11.55 7 94811 46068 64357846
Fluid retention 44.45 11.55 16 94802 59590 64344324
Wrong technique in product usage process 44.28 11.55 20 94798 64954 64338960
Anastomotic complication 44.13 11.55 18 94800 383 64403531
Coronary artery disease 43.76 11.55 17 94801 60416 64343498
Pneumonia 43.48 11.55 571 94247 559005 63844909
Venous thrombosis 43.06 11.55 50 94768 6331 64397583
Asthenia 43.05 11.55 875 93943 427169 63976745
Superior vena cava syndrome 42.87 11.55 24 94794 1051 64402863
Dysarthria 42.77 11.55 187 94631 59219 64344695
Trichomegaly 42.63 11.55 12 94806 75 64403839
Hypokalaemia 42.54 11.55 316 94502 121587 64282327
Haemolytic anaemia 42.51 11.55 81 94737 15972 64387942
Human herpesvirus 6 infection 41.06 11.55 42 94776 4612 64399302
Sedation 41.06 11.55 6 94812 41456 64362458
Gait disturbance 40.70 11.55 124 94694 172031 64231883
Type II hypersensitivity 40.70 11.55 10 94808 33 64403881
Lymphoid tissue hypoplasia 40.62 11.55 18 94800 473 64403441
Proteus infection 40.60 11.55 27 94791 1616 64402298
Confusional state 40.45 11.55 222 94596 260922 64142992
Portal vein thrombosis 40.38 11.55 43 94775 4948 64398966
Hand deformity 40.22 11.55 21 94797 62750 64341164
Hallucination 40.17 11.55 29 94789 72759 64331155
Peripheral sensorimotor neuropathy 39.99 11.55 32 94786 2553 64401361
Treatment noncompliance 39.31 11.55 8 94810 43474 64360440
Thymus hypoplasia 39.20 11.55 18 94800 515 64403399
ECG signs of myocardial ischaemia 39.12 11.55 16 94802 343 64403571
K-ras gene mutation 39.01 11.55 10 94808 41 64403873
Jugular vein thrombosis 38.29 11.55 37 94781 3794 64400120
Influenza 38.14 11.55 61 94757 106470 64297444
Productive cough 38.06 11.55 31 94787 73172 64330742
Drug dependence 37.60 11.55 3 94815 33309 64370605
Helicobacter infection 36.97 11.55 6 94812 38356 64365558
Loss of employment 36.96 11.55 27 94791 1880 64402034
Deep vein thrombosis 36.89 11.55 273 94545 104909 64299005
Febrile infection 36.76 11.55 32 94786 2869 64401045
Proctalgia 36.32 11.55 50 94768 7509 64396405
Nodular regenerative hyperplasia 36.27 11.55 20 94798 850 64403064
Immune thrombocytopenia 36.23 11.55 73 94745 14993 64388921
Blood glucose increased 36.21 11.55 55 94763 98018 64305896
Septic shock 36.04 11.55 272 94546 105165 64298749
Rectal perforation 35.96 11.55 19 94799 741 64403173
International normalised ratio increased 35.88 11.55 38 94780 79129 64324785
Pelvic fluid collection 35.86 11.55 18 94800 630 64403284
Small intestinal perforation 35.84 11.55 30 94788 2550 64401364
Enterobacter infection 35.64 11.55 35 94783 3661 64400253
Wound 35.46 11.55 36 94782 76441 64327473
Blister 35.44 11.55 40 94778 80927 64322987
Clostridium difficile colitis 35.36 11.55 104 94714 27119 64376795
Discomfort 35.36 11.55 40 94778 80838 64323076
Psoriasis 35.29 11.55 32 94786 71671 64332243
Unevaluable event 35.26 11.55 15 94803 50474 64353440
Product prescribing error 35.17 11.55 5 94813 35264 64368650
Respiratory arrest 35.04 11.55 17 94801 52968 64350946
Rectal tenesmus 34.94 11.55 21 94797 1052 64402862
Stress 34.89 11.55 23 94795 60511 64343403
Anal haemorrhage 34.79 11.55 33 94785 3307 64400607
Subclavian vein thrombosis 34.43 11.55 28 94790 2286 64401628
Varices oesophageal 34.29 11.55 40 94778 5090 64398824
Balance disorder 34.04 11.55 44 94774 83882 64320032
Emotional distress 33.92 11.55 6 94812 36032 64367882
Gastrointestinal anastomotic leak 33.75 11.55 15 94803 397 64403517
Acute coronary syndrome 33.39 11.55 82 94736 19228 64384686
Cystitis bacterial 33.37 11.55 15 94803 408 64403506
Exposure during pregnancy 33.32 11.55 39 94779 77636 64326278
Ileal perforation 33.03 11.55 19 94799 877 64403037
Ocular toxicity 32.99 11.55 17 94801 629 64403285
Factor VII deficiency 32.65 11.55 8 94810 26 64403888
Large intestinal obstruction 32.63 11.55 29 94789 2673 64401241
Norovirus test positive 32.45 11.55 15 94803 436 64403478
Enterocutaneous fistula 32.36 11.55 23 94795 1534 64402380
Gastrooesophageal reflux disease 32.29 11.55 45 94773 83098 64320816
Cardiac arrest 32.27 11.55 117 94701 153947 64249967
Anastomotic fistula 32.15 11.55 10 94808 92 64403822
Enterovesical fistula 32.05 11.55 19 94799 928 64402986
Oesophageal atresia 32.00 11.55 9 94809 56 64403858
Electrocardiogram ST segment elevation 31.89 11.55 46 94772 7213 64396701
Intentional self-injury 31.74 11.55 3 94815 29041 64374873
Blood cholesterol increased 31.71 11.55 17 94801 50049 64353865
Carbohydrate antigen 19-9 increased 31.69 11.55 14 94804 365 64403549
Hypoglycaemia 31.68 11.55 52 94766 89840 64314074
Intravascular haemolysis 31.26 11.55 17 94801 703 64403211
Neutropenic colitis 31.09 11.55 36 94782 4545 64399369
Recall phenomenon 30.99 11.55 19 94799 987 64402927
Injection site erythema 30.96 11.55 35 94783 70765 64333149
Arthritis 30.95 11.55 47 94771 83767 64320147
Portal shunt 30.73 11.55 9 94809 66 64403848
Cystitis radiation 30.31 11.55 10 94808 113 64403801
Blood creatine phosphokinase increased 30.19 11.55 25 94793 58533 64345381
Liver abscess 30.12 11.55 38 94780 5242 64398672
Leukoerythroblastosis 30.01 11.55 12 94806 242 64403672
Hypersensitivity vasculitis 29.93 11.55 43 94775 6718 64397196
Acute abdomen 29.60 11.55 28 94790 2796 64401118
Teratogenicity 29.52 11.55 9 94809 77 64403837
Hypoalbuminaemia 29.45 11.55 74 94744 17600 64386314
Gait inability 28.93 11.55 13 94805 42355 64361559
Neuromyotonia 28.82 11.55 9 94809 84 64403830
Medication error 28.78 11.55 19 94799 49947 64353967
Nephrotic syndrome 28.77 11.55 51 94767 9516 64394398
Liver function test abnormal 28.65 11.55 27 94791 59374 64344540
Koebner phenomenon 28.56 11.55 8 94810 49 64403865
Aortic thrombosis 28.36 11.55 21 94797 1493 64402421
Nasal septum perforation 28.35 11.55 16 94802 712 64403202
Necrotising fasciitis 28.30 11.55 37 94781 5289 64398625
Organising pneumonia 28.18 11.55 49 94769 9006 64394908
Klebsiella infection 28.03 11.55 61 94757 13220 64390694
Colon cancer recurrent 28.00 11.55 9 94809 93 64403821
Adverse drug reaction 27.98 11.55 16 94802 45448 64358466
Large intestine perforation 27.87 11.55 59 94759 12545 64391369
Cardio-respiratory arrest 27.69 11.55 65 94753 98328 64305586
Intentional product use issue 27.64 11.55 62 94756 95302 64308612
Influenza like illness 27.53 11.55 30 94788 61672 64342242
Encephalopathy 27.48 11.55 164 94654 58655 64345259
Stoma site haemorrhage 27.18 11.55 21 94797 1592 64402322
Short-bowel syndrome 27.00 11.55 13 94805 415 64403499
Encapsulating peritoneal sclerosis 26.49 11.55 16 94802 809 64403105
Prothrombin level decreased 26.47 11.55 20 94798 1466 64402448
Atypical haemolytic uraemic syndrome 26.38 11.55 15 94803 677 64403237
Migraine 26.32 11.55 32 94786 62645 64341269
Aggression 26.06 11.55 18 94800 46214 64357700
Agitation 25.98 11.55 57 94761 88310 64315604
Colon cancer metastatic 25.97 11.55 22 94796 1901 64402013
Cytomegalovirus chorioretinitis 25.90 11.55 34 94784 4878 64399036
Venous thrombosis limb 25.78 11.55 30 94788 3807 64400107
Dyspnoea 25.78 11.55 833 93985 717841 63686073
Oesophageal candidiasis 25.75 11.55 44 94774 7973 64395941
Condition aggravated 25.34 11.55 390 94428 372036 64031878
Loss of consciousness 25.28 11.55 122 94696 148243 64255671
Injection site haemorrhage 25.27 11.55 3 94815 24275 64379639
Gastrointestinal stoma complication 25.12 11.55 23 94795 2203 64401711
Perihepatic abscess 25.08 11.55 9 94809 133 64403781
Performance status decreased 25.05 11.55 35 94783 5329 64398585
Cytopenia 24.97 11.55 64 94754 15407 64388507
Laryngospasm 24.95 11.55 28 94790 3417 64400497
Cerebral haemorrhage 24.90 11.55 23 94795 51067 64352847
Venous pressure jugular decreased 24.86 11.55 8 94810 83 64403831
Duodenal ulcer perforation 24.64 11.55 10 94808 34615 64369299
Perineal disorder 24.61 11.55 6 94812 19 64403895
Evans syndrome 24.53 11.55 12 94806 397 64403517
Induration 24.47 11.55 20 94798 1644 64402270
Device related thrombosis 24.43 11.55 22 94796 2063 64401851
Pulmonary arterial hypertension 24.37 11.55 4 94814 25363 64378551
Knee arthroplasty 24.34 11.55 5 94813 26994 64376920
Hepatic lesion 24.27 11.55 36 94782 5788 64398126
Anal fissure 24.24 11.55 33 94785 4903 64399011
Visual impairment 24.15 11.55 45 94773 74032 64329882
Toxic erythema of chemotherapy 24.12 11.55 10 94808 222 64403692
Pericarditis 24.11 11.55 34 94784 62482 64341432
Viraemia 24.07 11.55 23 94795 2326 64401588
Irritability 23.98 11.55 12 94806 36734 64367180
Injection site reaction 23.96 11.55 20 94798 46644 64357270
Anaemia of malignant disease 23.91 11.55 14 94804 668 64403246
Cachexia 23.78 11.55 46 94772 9171 64394743
Interventricular septum rupture 23.72 11.55 6 94812 23 64403891
Urticaria 23.47 11.55 124 94694 147193 64256721
Proctitis 23.43 11.55 26 94792 3133 64400781
Meningitis streptococcal 23.20 11.55 9 94809 167 64403747
Depressed mood 23.08 11.55 16 94802 40996 64362918
C-reactive protein abnormal 23.05 11.55 7 94811 29040 64374874
Psychotic disorder 23.00 11.55 11 94807 34567 64369347
Oesophagitis 22.91 11.55 77 94741 21553 64382361
Chronic kidney disease 22.84 11.55 31 94787 57888 64346026
Dyskinesia 22.65 11.55 15 94803 39373 64364541
Pulmonary congestion 22.42 11.55 4 94814 23876 64380038
Allodynia 22.27 11.55 17 94801 1266 64402648
Vasospasm 22.18 11.55 15 94803 923 64402991
Ischiorectal hernia 22.14 11.55 5 94813 10 64403904
Bacteriuria 22.12 11.55 15 94803 927 64402987
Poisoning 22.05 11.55 3 94815 21876 64382038
Metastasis 22.03 11.55 34 94784 5661 64398253
Clostridial infection 21.85 11.55 32 94786 5087 64398827
Musculoskeletal stiffness 21.76 11.55 100 94718 123106 64280808
Nasopharyngitis 21.71 11.55 184 94634 195889 64208025
Hepatocellular injury 21.69 11.55 127 94691 45108 64358806
Incorrect dose administered 21.55 11.55 35 94783 60730 64343184
Haematopoietic stem cell mobilisation 21.42 11.55 9 94809 207 64403707
Periportal sinus dilatation 21.38 11.55 6 94812 37 64403877
Joint stiffness 21.28 11.55 9 94809 30395 64373519
Depilation 21.23 11.55 5 94813 13 64403901
Pulmonary toxicity 21.21 11.55 42 94776 8519 64395395
Oesophageal haemorrhage 21.14 11.55 18 94800 1566 64402348
Treatment failure 21.11 11.55 94 94724 116722 64287192
Erythema 20.97 11.55 389 94429 186681 64217233
Injection site pruritus 20.96 11.55 15 94803 37811 64366103
Hypoacusis 20.95 11.55 6 94812 25861 64378053
Aplasia 20.82 11.55 37 94781 6916 64396998
Pneumonitis 20.76 11.55 136 94682 50229 64353685
Injection site bruising 20.72 11.55 14 94804 36359 64367555
Hepatic failure 20.69 11.55 146 94672 55248 64348666
Muscle spasms 20.67 11.55 122 94696 140901 64263013
Full blood count abnormal 20.52 11.55 9 94809 29748 64374166
Obesity 20.30 11.55 3 94815 20559 64383355
Conjunctivitis 20.28 11.55 71 94747 20283 64383631
Visceral venous thrombosis 20.24 11.55 5 94813 17 64403897
Catabolic state 20.19 11.55 7 94811 93 64403821
Therapeutic product effect decreased 20.15 11.55 94 94724 115257 64288657
Swelling face 20.13 11.55 35 94783 59131 64344783
Stress cardiomyopathy 20.09 11.55 43 94775 9214 64394700
Myeloid leukaemia 20.06 11.55 12 94806 596 64403318
Abortion spontaneous 20.06 11.55 6 94812 25137 64378777
Acute kidney injury 20.04 11.55 829 93989 448411 63955503
Chemotherapy cardiotoxicity attenuation 20.02 11.55 5 94813 18 64403896
Multiple-drug resistance 19.99 11.55 35 94783 6467 64397447
Hypothyroidism 19.97 11.55 18 94800 40439 64363475
Heart rate increased 19.96 11.55 76 94742 98599 64305315
Haemolytic uraemic syndrome 19.93 11.55 27 94791 3994 64399920
Portal vein dilatation 19.92 11.55 6 94812 49 64403865
Tremor 19.78 11.55 132 94686 148098 64255816
Hepatitis B surface antigen positive 19.67 11.55 8 94810 169 64403745
Cataract 19.65 11.55 28 94790 51234 64352680
Pneumoperitoneum 19.57 11.55 22 94796 2689 64401225
Skin discolouration 19.51 11.55 14 94804 35241 64368673
Loss of personal independence in daily activities 19.48 11.55 49 94769 72405 64331509
Rectal cancer recurrent 19.41 11.55 5 94813 21 64403893
Perioral dermatitis 19.39 11.55 9 94809 264 64403650
Bronchitis 19.36 11.55 88 94730 108655 64295259
Hepatectomy 19.28 11.55 8 94810 178 64403736
Anal erythema 19.20 11.55 8 94810 180 64403734
Cerebrovascular accident 19.13 11.55 121 94697 137462 64266452
Sleep apnoea syndrome 19.08 11.55 10 94808 29822 64374092
Radiation interaction 18.84 11.55 6 94812 60 64403854
Product use issue 18.82 11.55 138 94680 151577 64252337
Pulmonary artery thrombosis 18.81 11.55 15 94803 1191 64402723
Jaundice 18.79 11.55 129 94689 48383 64355531
Endometrial dysplasia 18.70 11.55 5 94813 25 64403889
Hypertransaminasaemia 18.69 11.55 36 94782 7155 64396759
Aortic intramural haematoma 18.66 11.55 7 94811 118 64403796
Panic attack 18.64 11.55 4 94814 20949 64382965
Cerebral vasoconstriction 18.63 11.55 15 94803 1207 64402707
Adrenal insufficiency 18.62 11.55 5 94813 22482 64381432
Impaired healing 18.62 11.55 38 94780 60435 64343479
Prostatic calcification 18.58 11.55 6 94812 63 64403851
Laboratory test interference 18.56 11.55 14 94804 1024 64402890
Pregnancy 18.53 11.55 4 94814 20861 64383053
Cranial nerve disorder 18.43 11.55 13 94805 857 64403057
Cholestasis 18.39 11.55 121 94697 44751 64359163
Palpitations 18.33 11.55 85 94733 104403 64299511
Duodenal perforation 18.33 11.55 18 94800 1882 64402032
Oesophageal fistula 18.28 11.55 9 94809 302 64403612
Psoriatic arthropathy 18.27 11.55 22 94796 43259 64360655
Bladder hypertrophy 18.27 11.55 11 94807 553 64403361
Upper respiratory tract infection 18.23 11.55 51 94767 72734 64331180
Mouth ulceration 18.17 11.55 95 94723 32349 64371565
Cardiac disorder 18.11 11.55 34 94784 55782 64348132
Product administration error 18.08 11.55 9 94809 27634 64376280
Pain in jaw 17.98 11.55 20 94798 40735 64363179
Viral hepatitis carrier 17.93 11.55 5 94813 30 64403884
Oesophagobronchial fistula 17.92 11.55 8 94810 214 64403700
Hypotension 17.88 11.55 425 94393 380549 64023365
Cough 17.72 11.55 325 94493 301823 64102091
Mixed adenoneuroendocrine carcinoma 17.71 11.55 4 94814 8 64403906
Blood pressure decreased 17.69 11.55 66 94752 86133 64317781
Obstructive airways disorder 17.67 11.55 6 94812 23179 64380735
Fear 17.64 11.55 4 94814 20167 64383747
Product quality issue 17.61 11.55 11 94807 29788 64374126
Injection site swelling 17.48 11.55 21 94797 41332 64362582
Rhinovirus infection 17.47 11.55 32 94786 6124 64397790
Tumour perforation 17.44 11.55 9 94809 334 64403580
Perineal abscess 17.41 11.55 10 94808 460 64403454
Rectal abscess 17.40 11.55 16 94802 1541 64402373
Faeces discoloured 17.40 11.55 8 94810 25721 64378193
Biliary tract infection 17.39 11.55 13 94805 938 64402976
Hypertrichosis 17.31 11.55 14 94804 1134 64402780
Road traffic accident 17.29 11.55 12 94806 30733 64373181
Systemic scleroderma 17.24 11.55 13 94805 950 64402964
Portal venous gas 17.22 11.55 9 94809 343 64403571
Hyperthyroidism 17.17 11.55 3 94815 18176 64385738
Hepatotoxicity 17.13 11.55 109 94709 39853 64364061
Restlessness 17.03 11.55 20 94798 39765 64364149
Perforation bile duct 17.03 11.55 5 94813 37 64403877
Head injury 16.96 11.55 14 94804 32828 64371086
Type 2 diabetes mellitus 16.96 11.55 15 94803 34005 64369909
Gastrointestinal necrosis 16.83 11.55 28 94790 4964 64398950
Hypocalcaemia 16.75 11.55 112 94706 41641 64362273
Adverse event 16.75 11.55 20 94798 39469 64364445
Catheter site extravasation 16.71 11.55 9 94809 365 64403549
Anal erosion 16.69 11.55 5 94813 40 64403874
Peritoneal neoplasm 16.64 11.55 6 94812 90 64403824
Female genital tract fistula 16.57 11.55 20 94798 2638 64401276
Abnormal behaviour 16.55 11.55 15 94803 33607 64370307
Obstruction gastric 16.44 11.55 15 94803 1431 64402483
Herpes simplex 16.40 11.55 43 94775 10493 64393421
Lymphopenia 16.40 11.55 78 94740 25579 64378335
Brief psychotic disorder with marked stressors 16.40 11.55 8 94810 263 64403651
Thrombocytopenic purpura 16.39 11.55 18 94800 2144 64401770
Bladder tamponade 16.35 11.55 10 94808 517 64403397
Soft tissue necrosis 16.26 11.55 11 94807 677 64403237
Rheumatoid arthritis 16.09 11.55 159 94659 164135 64239779
Subacute cutaneous lupus erythematosus 16.05 11.55 21 94797 3004 64400910
Dysstasia 16.04 11.55 7 94811 23208 64380706
Amnesia 16.02 11.55 29 94789 48240 64355674
Coronavirus infection 16.01 11.55 29 94789 5501 64398413
Red cell fragmentation syndrome 15.98 11.55 5 94813 47 64403867
Retinitis viral 15.90 11.55 6 94812 103 64403811
Temperature difference of extremities 15.89 11.55 4 94814 15 64403899
Upper gastrointestinal haemorrhage 15.85 11.55 17 94801 35203 64368711
Adenocarcinoma of colon 15.85 11.55 27 94791 4881 64399033
Nephropathy toxic 15.68 11.55 59 94759 17455 64386459
Hypervolaemia 15.60 11.55 20 94798 38265 64365649
Catheter site thrombosis 15.59 11.55 7 94811 190 64403724
Breast cancer 15.58 11.55 12 94806 29136 64374778
Inferior vena cava stenosis 15.53 11.55 5 94813 52 64403862
Dysaesthesia 15.50 11.55 27 94791 4968 64398946
Portal vein embolisation 15.49 11.55 4 94814 17 64403897
Hallucination, visual 15.47 11.55 11 94807 27823 64376091
Hypersplenism 15.40 11.55 9 94809 428 64403486
Full blood count decreased 15.31 11.55 7 94811 22575 64381339
Dysaesthesia pharynx 15.29 11.55 7 94811 199 64403715
Intestinal strangulation 15.28 11.55 5 94813 55 64403859
Acinetobacter sepsis 15.20 11.55 5 94813 56 64403858
Iatrogenic infection 15.04 11.55 5 94813 58 64403856
Organic brain syndrome 15.01 11.55 9 94809 449 64403465
Cutaneous tuberculosis 14.94 11.55 7 94811 210 64403704
Delusion 14.92 11.55 4 94814 18010 64385904
Diabetes mellitus 14.91 11.55 49 94769 66425 64337489
Portal tract inflammation 14.83 11.55 6 94812 125 64403789
Vocal cord paralysis 14.79 11.55 17 94801 2129 64401785
Pruritus 14.78 11.55 348 94470 312052 64091862
Neurosarcoidosis 14.77 11.55 8 94810 328 64403586
Product substitution issue 14.73 11.55 4 94814 17857 64386057
Mania 14.71 11.55 3 94815 16283 64387631
Astringent therapy 14.64 11.55 4 94814 22 64403892
Gastric varices haemorrhage 14.62 11.55 8 94810 335 64403579
Optic neuropathy 14.59 11.55 20 94798 2991 64400923
Splenic abscess 14.55 11.55 9 94809 475 64403439
Anal fistula 14.52 11.55 27 94791 5226 64398688
Myopathy 14.51 11.55 4 94814 17676 64386238
Tumour fistulisation 14.49 11.55 4 94814 23 64403891
Therapy non-responder 14.49 11.55 49 94769 65850 64338064
Encephalitis 14.43 11.55 46 94772 12525 64391389
Fistula of small intestine 14.37 11.55 10 94808 645 64403269
Pleural fistula 14.35 11.55 4 94814 24 64403890
Mood altered 14.32 11.55 3 94815 15976 64387938
Streptococcal bacteraemia 14.30 11.55 20 94798 3047 64400867
Haematoma 14.29 11.55 29 94789 46221 64357693
Angioedema 14.26 11.55 45 94773 61776 64342138
Prescribed overdose 14.26 11.55 6 94812 20325 64383589
Joint injury 14.23 11.55 8 94810 22939 64380975
Fibromyalgia 14.21 11.55 19 94799 35712 64368202
Toxic encephalopathy 14.21 11.55 39 94779 9776 64394138
Disseminated aspergillosis 14.19 11.55 10 94808 658 64403256
Electromyogram abnormal 14.12 11.55 6 94812 142 64403772
Benign hydatidiform mole 14.05 11.55 5 94813 72 64403842
Neck pain 14.05 11.55 45 94773 61488 64342426
Injection site mass 14.00 11.55 4 94814 17266 64386648
Escherichia bacteraemia 13.98 11.55 27 94791 5376 64398538
Malaise 13.98 11.55 460 94358 395787 64008127
Dermatitis 13.93 11.55 58 94760 17971 64385943
Vitiligo 13.89 11.55 15 94803 1753 64402161
Device issue 13.89 11.55 8 94810 22640 64381274
Bacteraemia 13.85 11.55 77 94741 26834 64377080
Dysphonia 13.84 11.55 116 94702 46266 64357648
VIth nerve disorder 13.82 11.55 4 94814 28 64403886
Product intolerance 13.82 11.55 4 94814 28 64403886
Oedema 13.75 11.55 79 94739 91856 64312058
Disseminated intravascular coagulation 13.72 11.55 88 94730 32260 64371654
Rash maculo-papular 13.71 11.55 117 94701 46909 64357005
Lip swelling 13.70 11.55 16 94802 31891 64372023
Pneumomediastinum 13.66 11.55 19 94799 2881 64401033
Rectal haemorrhage 13.64 11.55 145 94673 61672 64342242
Neuralgia 13.53 11.55 75 94743 26109 64377805
Rectal adenocarcinoma 13.48 11.55 13 94805 1330 64402584
Biliary obstruction 13.47 11.55 22 94796 3842 64400072
Mydriasis 13.47 11.55 3 94815 15309 64388605
Ovarian fibroma 13.40 11.55 5 94813 83 64403831
Underdose 13.35 11.55 11 94807 25818 64378096
Colitis microscopic 13.32 11.55 32 94786 7400 64396514
Radiation hepatitis 13.29 11.55 3 94815 6 64403908
Ovarian cystectomy 13.24 11.55 5 94813 86 64403828
Therapy cessation 13.21 11.55 17 94801 32472 64371442
Accidental overdose 13.19 11.55 18 94800 33539 64370375
Ulcerative gastritis 13.19 11.55 5 94813 87 64403827
Oesophageal varices haemorrhage 13.11 11.55 21 94797 3608 64400306
Illness 13.10 11.55 8 94810 21930 64381984
Blood glucose decreased 13.04 11.55 9 94809 23114 64380800
Occult blood 13.00 11.55 13 94805 1389 64402525
Anal infection 12.98 11.55 5 94813 91 64403823
Adenocarcinoma 12.95 11.55 20 94798 3331 64400583
Hypocapnia 12.92 11.55 9 94809 581 64403333
Sinus bradycardia 12.79 11.55 9 94809 22884 64381030
Bacterial colitis 12.78 11.55 5 94813 95 64403819
Cognitive disorder 12.78 11.55 40 94778 55047 64348867
Mental disorder 12.77 11.55 12 94806 26433 64377481
Overgrowth fungal 12.73 11.55 5 94813 96 64403818
Sleep disorder 12.72 11.55 45 94773 59664 64344250
Fanconi syndrome 12.71 11.55 17 94801 2484 64401430
Sarcoidosis 12.71 11.55 28 94790 6118 64397796
Cardiomyopathy 12.68 11.55 72 94746 25284 64378630
Axonal neuropathy 12.68 11.55 14 94804 1678 64402236
Fluid balance positive 12.65 11.55 4 94814 39 64403875
Multiple sclerosis 12.64 11.55 6 94812 18935 64384979
No adverse event 12.62 11.55 14 94804 28547 64375367
Urticarial vasculitis 12.59 11.55 8 94810 443 64403471
Granulomatous liver disease 12.59 11.55 12 94806 1210 64402704
Gout 12.52 11.55 8 94810 21405 64382509
Muscle rigidity 12.51 11.55 5 94813 17468 64386446
Lactobacillus infection 12.51 11.55 6 94812 190 64403724
Paraesthesia mucosal 12.48 11.55 4 94814 41 64403873
Gastric ulcer perforation, obstructive 12.43 11.55 3 94815 9 64403905
Hepatitis B DNA increased 12.39 11.55 9 94809 621 64403293
Hemianaesthesia 12.36 11.55 8 94810 457 64403457
Endocarditis 12.34 11.55 36 94782 9342 64394572
Dyspnoea exertional 12.34 11.55 61 94757 73669 64330245
B-cell small lymphocytic lymphoma 12.28 11.55 5 94813 106 64403808
Malignant ascites 12.26 11.55 11 94807 1027 64402887
Pseudocirrhosis 12.20 11.55 9 94809 636 64403278
Hypothermia 12.20 11.55 7 94811 19849 64384065
Optic disc hyperaemia 12.19 11.55 3 94815 10 64403904
Peritoneal disorder 12.15 11.55 9 94809 640 64403274
Keratitis 12.07 11.55 19 94799 3218 64400696
Device occlusion 12.05 11.55 37 94781 9876 64394038
Enterocolitis 12.04 11.55 42 94776 11976 64391938
Hand-foot-genital syndrome 11.97 11.55 3 94815 11 64403903
Ventricular tachycardia 11.90 11.55 20 94798 34245 64369669
Retroperitoneal abscess 11.90 11.55 7 94811 337 64403577
Arrhythmia 11.89 11.55 39 94779 52905 64351009
Limbic encephalitis 11.89 11.55 9 94809 662 64403252
Cytomegalovirus viraemia 11.87 11.55 39 94779 10789 64393125
Nephrectasia 11.76 11.55 3 94815 12 64403902
Neuropathic muscular atrophy 11.76 11.55 4 94814 50 64403864
Drug eruption 11.73 11.55 22 94796 36114 64367800
Presyncope 11.72 11.55 21 94797 35068 64368846
Respiratory disorder 11.71 11.55 22 94796 36089 64367825
Cellulitis 11.70 11.55 85 94733 93572 64310342
Myelodysplastic syndrome 11.68 11.55 75 94743 27504 64376410
Granulomatous lymphadenitis 11.64 11.55 6 94812 222 64403692
Intra-abdominal fluid collection 11.62 11.55 17 94801 2700 64401214
Hyperkalaemia 11.59 11.55 94 94724 101035 64302879
Sopor 11.57 11.55 16 94802 29645 64374269

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC V03AF03 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Detoxifying agents for antineoplastic treatment
ATC V03AF06 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Detoxifying agents for antineoplastic treatment
FDA CS M0008658 Folic Acid
MeSH PA D000931 Antidotes
MeSH PA D018977 Micronutrients
MeSH PA D020011 Protective Agents
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:76971 Escherichia coli metabolites
FDA EPC N0000178369 Folate Analog

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Megaloblastic anemia indication 53165003 DOID:13382
Folic acid deficiency indication 190633005
Bone Marrow Suppression due to Folic Acid Antagonism indication
Methotrexate Toxicity indication
Trimethoprim Toxicity indication
Trimetrexate Toxicity indication
Sulfadiazine Toxicity indication
Pyrimethamine Toxicity indication
Adjunct to Fluorouracil Treatment of Colorectal Cancer indication
Pernicious anemia contraindication 84027009 DOID:13381
Cobalamin deficiency contraindication 190634004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.61 acidic
pKa2 5.29 acidic
pKa3 10.26 acidic
pKa4 12.96 acidic
pKa5 4.59 Basic
pKa6 2.23 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Thymidylate synthase Enzyme Ki 4.07 WOMBAT-PK
Dihydrofolate reductase Enzyme Ki 5.63 CHEMBL

External reference:

IDSource
4019798 VUID
N0000147887 NUI
D01211 KEGG_DRUG
1492-18-8 SECONDARY_CAS_RN
4018768 VANDF
4019798 VANDF
4031236 VANDF
C0023413 UMLSCUI
CHEBI:15640 CHEBI
CHEMBL1679 ChEMBL_ID
CHEMBL3707260 ChEMBL_ID
CHEMBL1232801 ChEMBL_ID
CHEMBL1201138 ChEMBL_ID
D002955 MESH_DESCRIPTOR_UI
DB00650 DRUGBANK_ID
4816 IUPHAR_LIGAND_ID
Q573I9DVLP UNII
135403648 PUBCHEM_CID
225852 RXNORM
1728 MMSL
39896 MMSL
4964 MMSL
51342 MMSL
d00275 MMSL
001050 NDDF
001051 NDDF
009520 NDDF
126223008 SNOMEDCT_US
1528001 SNOMEDCT_US
396065004 SNOMEDCT_US
768550004 SNOMEDCT_US
690 INN_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0054-4496 TABLET 5 mg ORAL ANDA 15 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0054-4497 TABLET 10 mg ORAL ANDA 15 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0054-4498 TABLET 15 mg ORAL ANDA 15 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0054-4499 TABLET 25 mg ORAL ANDA 15 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0054-8496 TABLET 5 mg ORAL ANDA 15 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9368 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 200 mg INTRAMUSCULAR ANDA 19 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9552 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 350 mg INTRAMUSCULAR ANDA 19 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9553 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 200 mg INTRAMUSCULAR ANDA 19 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9554 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAMUSCULAR ANDA 19 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9555 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 50 mg INTRAMUSCULAR ANDA 19 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0555-0484 TABLET 5 mg ORAL ANDA 17 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0555-0485 TABLET 25 mg ORAL ANDA 17 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0703-5140 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAMUSCULAR ANDA 18 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0703-5145 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 350 mg INTRAMUSCULAR ANDA 18 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0703-5145 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 350 mg INTRAMUSCULAR ANDA 18 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0904-6703 TABLET 25 mg ORAL ANDA 15 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 25021-813 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 50 mg INTRAVENOUS ANDA 21 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 25021-814 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS ANDA 21 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 25021-815 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 200 mg INTRAVENOUS ANDA 21 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 25021-816 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 350 mg INTRAVENOUS ANDA 21 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 25021-828 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 500 mg INTRAVENOUS ANDA 21 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 42806-133 TABLET 10 mg ORAL ANDA 16 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 42806-134 TABLET 15 mg ORAL ANDA 16 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 42806-358 TABLET 5 mg ORAL ANDA 16 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 42806-359 TABLET 25 mg ORAL ANDA 16 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 50742-181 TABLET 5 mg ORAL ANDA 17 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 50742-182 TABLET 10 mg ORAL ANDA 17 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 50742-183 TABLET 15 mg ORAL ANDA 17 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 50742-184 TABLET 25 mg ORAL ANDA 17 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 51079-581 TABLET 5 mg ORAL ANDA 17 sections