fluprednisolone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 1216 53-34-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • fluprednisolone
  • alphadrol
  • etadrol
A synthetic glucocorticoid with anti-inflammatory properties.
  • Molecular weight: 378.44
  • Formula: C21H27FO5
  • CLOGP: 1.47
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 94.83
  • ALOGS: -3.16
  • ROTB: 2
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 7, 1982 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.18 acidic
pKa2 12.91 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST CHEMBL CHEMBL

External reference:

IDSource
N0000167459 NUI
D04227 KEGG_DRUG
C0016369 UMLSCUI
CHEBI:34474 CHEBI
CHEMBL1200774 ChEMBL_ID
DB09378 DRUGBANK_ID
D005477 MESH_DESCRIPTOR_UI
5876 PUBCHEM_CID
1352 INN_ID
9H05937G3X UNII
4497 RXNORM
002163 NDDF
116599004 SNOMEDCT_US
4126008 SNOMEDCT_US

Pharmaceutical products:

None