DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
Scroll
All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
fluindione 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
1194
957-56-2
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
fluindione
previscan
Molecular weight: 240.23
Formula: C15H9FO2
CLOGP: 2.95
LIPINSKI: 0
HAC: 2
HDO: 0
TPSA: 34.14
ALOGS: -3.64
ROTB: 1
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
International normalised ratio increased
719.40
36.07
225
4584
46200
63438013
Drug interaction
464.61
36.07
259
4550
228872
63255341
Acute kidney injury
293.79
36.07
204
4605
263211
63221002
Haematoma
182.63
36.07
76
4733
34744
63449469
Shock haemorrhagic
178.02
36.07
54
4755
9841
63474372
Anaemia
170.12
36.07
155
4654
293275
63190938
Melaena
161.65
36.07
67
4742
30298
63453915
Cerebral haematoma
144.26
36.07
37
4772
3646
63480567
Hyperkalaemia
127.42
36.07
68
4741
54135
63430078
Bradycardia
116.01
36.07
71
4738
73156
63411057
Showing 1 to 10 of 31 entries
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1
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FDA Adverse Event Reporting System (Male)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
International normalised ratio increased
528.90
25.77
228
6205
47099
34903399
Acute kidney injury
333.15
25.77
339
6094
304649
34645849
Drug interaction
277.02
25.77
268
6165
225678
34724820
Hyperkalaemia
180.85
25.77
128
6305
69261
34881237
Cerebral haematoma
179.65
25.77
56
6377
4559
34945939
Shock haemorrhagic
178.26
25.77
70
6363
11284
34939214
Haematoma
134.88
25.77
74
6359
25531
34924967
Blood lactic acid
89.36
25.77
19
6414
327
34950171
Rectal haemorrhage
83.84
25.77
65
6368
40184
34910314
Melaena
75.56
25.77
58
6375
35322
34915176
Showing 1 to 10 of 47 entries
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1
2
3
4
5
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FDA Adverse Event Reporting System (Geriatric)
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entries
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
International normalised ratio increased
1189.58
26.60
448
10966
84273
79648701
Drug interaction
676.83
26.60
520
10894
414663
79318311
Acute kidney injury
614.79
26.60
540
10874
518864
79214110
Shock haemorrhagic
346.44
26.60
124
11290
19936
79713038
Haematoma
305.30
26.60
149
11265
52046
79680928
Cerebral haematoma
304.93
26.60
90
11324
7852
79725122
Hyperkalaemia
303.36
26.60
194
11220
114204
79618770
Melaena
214.55
26.60
124
11290
60766
79672208
Anaemia
191.42
26.60
274
11140
444741
79288233
Bradycardia
172.84
26.60
148
11266
135409
79597565
Showing 1 to 10 of 73 entries
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FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
B01AA12
BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Vitamin K antagonists
MeSH PA
D000925
Anticoagulants
MeSH PA
D006401
Hematologic Agents
Showing 1 to 3 of 3 entries
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
4.43
acidic
Showing 1 to 1 of 1 entries
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Arachidonate 5-lipoxygenase
Enzyme
LOX5_RAT
IC50
5.02
CHEMBL
Showing 1 to 1 of 1 entries
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1
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External reference:
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100
entries
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ID
Source
005420
NDDF
19351000122101
SNOMEDCT_US
4519
INN_ID
50097
RXNORM
68942
PUBCHEM_CID
C0117899
UMLSCUI
C017673
MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:134975
CHEBI
CHEMBL24924
ChEMBL_ID
D07969
KEGG_DRUG
Showing 1 to 10 of 12 entries
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Pharmaceutical products:
None
Search
Structure 🔎
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L1000
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fluindione