All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

fexofenadine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	1170	83799-24-0

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: fexofenadine terfenadine carboxylate fexofenadine hydrochloride fexofenadine HCl	a second generation antihistamine; metabolite of the antihistaminic drug terfenadine; ; RN refers to HCl Molecular weight: 501.67 Formula: C32H39NO4 CLOGP: 1.96 LIPINSKI: 1 HAC: 5 HDO: 3 TPSA: 81 ALOGS: -5.28 ROTB: 10 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
0.12	g	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	3	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	25 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	5.13 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	70 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
S (Water solubility)	3.60 mg/mL	Bocci G, Oprea TI, Benet LZ

Approvals:

Date	Agency	Company	Orphan
July 25, 1996	FDA	SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Urticaria	140.11	10.93	298	35750	165504	63287470
Dermatitis atopic	128.87	10.93	76	35972	9648	63443326
Pruritus	108.58	10.93	449	35599	361004	63091970
Contraindicated product administered	106.05	10.93	4	36044	217644	63235330
Synovitis	92.58	10.93	3	36045	186915	63266059
Seasonal allergy	88.27	10.93	82	35966	20868	63432106
Angioedema	79.44	10.93	116	35932	47849	63405125
Lip swelling	79.34	10.93	93	35955	30970	63422004
Asthma	74.78	10.93	199	35849	127362	63325612
Systemic lupus erythematosus	72.75	10.93	15	36033	208903	63244071
Hand deformity	71.16	10.93	5	36043	159452	63293522
Toxicity to various agents	64.26	10.93	30	36018	247220	63205754
Glossodynia	64.05	10.93	12	36036	178864	63274110
COVID-19	62.83	10.93	173	35875	112930	63340044
Therapeutic product effect decreased	61.11	10.93	17	36031	193170	63259804
Completed suicide	58.50	10.93	7	36041	145666	63307308
Treatment failure	58.50	10.93	20	36028	199023	63253951
Sinusitis	58.30	10.93	269	35779	226384	63226590
Pharyngeal swelling	57.19	10.93	39	36009	6365	63446609
General physical health deterioration	53.00	10.93	24	36024	201378	63251596
Joint swelling	52.89	10.93	65	35983	327601	63125373
Anaphylactic reaction	50.27	10.93	114	35934	65986	63386988
Arthropathy	49.02	10.93	37	36011	234755	63218219
Dry skin	48.82	10.93	103	35945	56784	63396190
Eye pruritus	47.84	10.93	56	35992	18615	63434359
Product dose omission issue	47.47	10.93	260	35788	234053	63218921
Swelling face	44.46	10.93	106	35942	63369	63389605
Maternal exposure during pregnancy	44.26	10.93	36	36012	220026	63232948
Bronchitis	42.83	10.93	162	35886	124773	63328201
Headache	42.14	10.93	546	35502	632695	62820279
Wound	42.10	10.93	20	36028	163243	63289731
Feeling abnormal	41.79	10.93	181	35867	148211	63304763
Rheumatoid arthritis	41.31	10.93	50	35998	253769	63199205
Helicobacter infection	41.12	10.93	3	36045	92782	63360192
Drug intolerance	38.47	10.93	73	35975	308588	63144386
Mast cell activation syndrome	37.47	10.93	15	36033	810	63452164
Pre-existing condition improved	36.14	10.93	33	36015	8211	63444763
Illness	35.52	10.93	83	35965	48976	63403998
Rash	35.35	10.93	479	35569	560392	62892582
Hepatic enzyme increased	34.92	10.93	38	36010	202290	63250684
Hypotension	34.38	10.93	64	35984	272540	63180434
Throat tightness	33.90	10.93	55	35993	24832	63428142
Nasal pruritus	33.36	10.93	12	36036	482	63452492
Insomnia	32.27	10.93	221	35827	215031	63237943
Eczema	31.90	10.93	62	35986	32229	63420745
Multiple allergies	31.44	10.93	39	36009	13763	63439211
Cardiospasm	30.90	10.93	17	36031	1890	63451084
Pruritus genital	30.66	10.93	19	36029	2635	63450339
Migraine	30.58	10.93	128	35920	103218	63349756
Palmoplantar keratoderma	30.09	10.93	17	36031	1990	63450984
Dizziness	29.48	10.93	373	35675	429552	63023422
Anosmia	29.18	10.93	27	36021	6833	63446141
Hereditary angioedema	28.80	10.93	28	36020	7534	63445440
Cough	27.35	10.93	270	35778	292473	63160501
Upper respiratory tract infection	26.96	10.93	105	35943	81942	63371032
Folliculitis	26.74	10.93	4	36044	70313	63382661
Drug ineffective	26.55	10.93	426	35622	1044339	62408635
Chronic spontaneous urticaria	26.47	10.93	13	36035	1144	63451830
Chest discomfort	26.38	10.93	128	35920	109841	63343133
Impaired healing	25.76	10.93	13	36035	102529	63350445
Sleep terror	25.55	10.93	17	36031	2663	63450311
Sinus disorder	24.08	10.93	47	36001	24506	63428468
Skin exfoliation	23.98	10.93	66	35982	43036	63409938
Infusion site pain	23.96	10.93	38	36010	16831	63436143
Nausea	23.91	10.93	644	35404	853827	62599147
Hypohidrosis	23.81	10.93	6	36042	68	63452906
Muscle spasms	23.79	10.93	161	35887	155989	63296985
Infusion related reaction	22.66	10.93	68	35980	245453	63207521
Eye swelling	22.51	10.93	45	36003	23873	63429101
Pericarditis	22.38	10.93	25	36023	131554	63321420
Nasal disorder	22.21	10.93	16	36032	2848	63450126
Drug interaction	22.21	10.93	62	35986	229069	63223905
Rash macular	22.04	10.93	44	36004	23320	63429654
Pain of skin	22.01	10.93	30	36018	11604	63441370
Skin swelling	21.66	10.93	17	36031	3442	63449532
Genital rash	21.35	10.93	9	36039	555	63452419
Thrombocytopenia	21.32	10.93	33	36015	151124	63301850
Tension headache	21.26	10.93	20	36028	5166	63447808
Lip discolouration	20.93	10.93	9	36039	583	63452391
Nasal congestion	19.95	10.93	82	35966	65578	63387396
Diarrhoea	19.64	10.93	538	35510	714828	62738146
Oropharyngeal spasm	19.46	10.93	7	36041	281	63452693
Tinnitus	19.27	10.93	54	35994	35574	63417400
Eye haematoma	19.07	10.93	5	36043	67	63452907
Product quality issue	19.04	10.93	54	35994	35811	63417163
Acute kidney injury	18.95	10.93	81	35967	263334	63189640
Mucosal discolouration	18.87	10.93	8	36040	500	63452474
Atrial tachycardia	18.64	10.93	17	36031	4223	63448751
Therapeutic response unexpected	18.50	10.93	36	36012	18723	63434251
Essential tremor	18.46	10.93	10	36038	1078	63451896
Rash pruritic	18.42	10.93	75	35973	59724	63393250
Swollen tongue	18.09	10.93	52	35996	34748	63418226
Musculoskeletal stiffness	17.85	10.93	50	35998	184568	63268406
Cerebral disorder	17.69	10.93	17	36031	4509	63448465
Immunisation	17.60	10.93	10	36038	1183	63451791
Urticaria aquagenic	17.24	10.93	4	36044	31	63452943
Carotid artery occlusion	17.17	10.93	17	36031	4677	63448297
Urticaria cholinergic	17.13	10.93	4	36044	32	63452942
Diplopia	17.01	10.93	40	36008	23688	63429286
Rhinorrhoea	16.94	10.93	78	35970	65499	63387475
Death	16.82	10.93	134	35914	374247	63078727
Anxiety	16.72	10.93	193	35855	217348	63235626
Swelling	16.71	10.93	90	35958	275288	63177686
Exposure during pregnancy	16.67	10.93	40	36008	155507	63297467
Dry eye	16.64	10.93	56	35992	40705	63412269
Oropharyngeal pain	16.58	10.93	101	35947	94386	63358588
Mobility decreased	16.57	10.93	27	36021	121132	63331842
Dysphonia	16.51	10.93	62	35986	47552	63405422
Neurosis	16.20	10.93	6	36042	262	63452712
Carcinoid syndrome	16.15	10.93	5	36043	125	63452849
Multiple organ dysfunction syndrome	16.15	10.93	6	36042	56746	63396228
Injection site rash	16.06	10.93	34	36014	18775	63434199
Vulvovaginal injury	15.48	10.93	7	36041	511	63452463
Endometriosis	15.40	10.93	17	36031	5303	63447671
Infusion site swelling	15.26	10.93	23	36025	9747	63443227
Palpitations	15.25	10.93	113	35935	112657	63340317
Eye discharge	15.22	10.93	18	36030	6045	63446929
Exposure to allergen	14.99	10.93	6	36042	324	63452650
Coma	14.94	10.93	9	36039	64355	63388619
Erythema	14.91	10.93	159	35889	175592	63277382
Infusion site erythema	14.81	10.93	25	36023	11654	63441320
Subarachnoid haemorrhage	14.81	10.93	28	36020	14255	63438719
Type 2 diabetes mellitus	14.73	10.93	9	36039	63859	63389115
Oropharyngeal oedema	14.66	10.93	6	36042	343	63452631
Sleep apnoea syndrome	14.63	10.93	43	36005	29090	63423884
Dermatitis contact	14.55	10.93	24	36024	10984	63441990
Inappropriate schedule of product administration	14.53	10.93	105	35943	103860	63349114
Sneezing	14.49	10.93	32	36016	18186	63434788
Infusion site haemorrhage	14.28	10.93	16	36032	5070	63447904
Burning feet syndrome	14.27	10.93	4	36044	70	63452904
Drug eruption	14.08	10.93	42	36006	28652	63424322
Depression	14.07	10.93	172	35876	196320	63256654
Product use issue	13.97	10.93	71	35977	220449	63232525
Facial pain	13.92	10.93	23	36025	10538	63442436
Nerve compression	13.64	10.93	21	36027	9066	63443908
Pulmonary fibrosis	13.55	10.93	3	36045	39806	63413168
Insurance issue	13.47	10.93	17	36031	6104	63446870
Product dose omission in error	13.46	10.93	19	36029	7593	63445381
Rhinitis allergic	13.44	10.93	24	36024	11703	63441271
Seborrhoeic dermatitis	12.89	10.93	8	36040	1113	63451861
Psoriasis	12.84	10.93	89	35959	86868	63366106
Laryngeal oedema	12.77	10.93	16	36032	5702	63447272
Respiratory failure	12.74	10.93	24	36024	101834	63351140
Paranasal sinus discomfort	12.69	10.93	14	36034	4362	63448612
Lower respiratory tract infection	12.66	10.93	36	36012	132271	63320703
Tongue discolouration	12.66	10.93	12	36036	3131	63449843
Upper-airway cough syndrome	12.61	10.93	23	36025	11395	63441579
Poor quality device used	12.58	10.93	10	36038	2061	63450913
Perfume sensitivity	12.56	10.93	7	36041	798	63452176
Ocular hyperaemia	12.52	10.93	37	36011	25107	63427867
Alopecia	12.45	10.93	127	35921	337409	63115565
Sinus congestion	12.40	10.93	30	36018	18093	63434881
Confusional state	12.35	10.93	81	35967	236299	63216675
Allergic bronchitis	12.16	10.93	3	36045	31	63452943
Trichoglossia	12.08	10.93	5	36043	294	63452680
Drug abuse	12.08	10.93	14	36034	72504	63380470
Alopecia universalis	12.04	10.93	4	36044	126	63452848
Overdose	12.01	10.93	30	36018	115048	63337926
Impaired quality of life	11.87	10.93	25	36023	13758	63439216
Injection site swelling	11.85	10.93	56	35992	47516	63405458
Leukopenia	11.75	10.93	16	36032	77274	63375700
Oropharyngeal swelling	11.68	10.93	7	36041	914	63452060
Product administration interrupted	11.55	10.93	14	36034	4822	63448152
Influenza	11.49	10.93	103	35945	108619	63344355
Throat irritation	11.42	10.93	47	36001	37600	63415374
Gastrooesophageal reflux disease	11.36	10.93	93	35955	95546	63357428
Antibody test negative	11.32	10.93	3	36045	42	63452932
Immunisation reaction	11.28	10.93	6	36042	624	63452350
Renal failure	11.27	10.93	32	36016	117620	63335354
Myalgia	11.25	10.93	130	35918	146399	63306575
Loss of personal independence in daily activities	11.25	10.93	24	36024	97266	63355708
Product size issue	11.19	10.93	5	36043	355	63452619
Hallucination	11.18	10.93	61	35987	54756	63398218
Spider naevus	11.06	10.93	4	36044	163	63452811
Flatulence	11.06	10.93	44	36004	34658	63418316
Leukoplakia oral	10.97	10.93	4	36044	167	63452807

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pruritus	51.12	13.61	148	13793	141833	34801157
Dermatitis atopic	43.70	13.61	27	13914	5320	34937670
Toxicity to various agents	41.68	13.61	14	13927	200348	34742642
Sinusitis	37.95	13.61	63	13878	41339	34901651
Urticaria	37.27	13.61	79	13862	62298	34880692
Lip swelling	36.06	13.61	38	13903	16042	34926948
Anaphylactic reaction	34.91	13.61	53	13888	32248	34910742
Alopecia areata	32.07	13.61	9	13932	229	34942761
Skin texture abnormal	29.03	13.61	6	13935	38	34942952
Rash	28.76	13.61	169	13772	222583	34720407
General physical health deterioration	28.38	13.61	8	13933	128261	34814729
Hepatic function abnormal	24.00	13.61	54	13887	44309	34898681
Butterfly rash	23.66	13.61	6	13935	102	34942888
Headache	22.59	13.61	147	13794	200488	34742502
Pemphigoid	22.19	13.61	22	13919	8644	34934346
Drug eruption	21.99	13.61	33	13908	19865	34923125
Genital swelling	21.04	13.61	6	13935	162	34942828
Pharyngeal ulceration	20.06	13.61	7	13934	369	34942621
Rhinitis allergic	19.02	13.61	13	13928	3037	34939953
Mast cell activation syndrome	18.69	13.61	6	13935	244	34942746
Alopecia universalis	17.97	13.61	5	13936	123	34942867
Asthma	17.81	13.61	47	13894	42609	34900381
Pharyngeal swelling	17.37	13.61	11	13930	2261	34940729
Hypersensitivity	16.74	13.61	58	13883	60977	34882013
Eyelid skin dryness	15.51	13.61	4	13937	73	34942917
Allergy to plants	15.47	13.61	3	13938	13	34942977
Bronchitis	15.30	13.61	44	13897	41919	34901071
Myalgia	15.09	13.61	70	13871	84040	34858950
Renal failure	14.99	13.61	18	13923	130539	34812451
Overdose	14.79	13.61	9	13932	91050	34851940
Decreased appetite	14.68	13.61	115	13826	166277	34776713
Oropharyngeal swelling	14.59	13.61	6	13935	497	34942493
Sleep disorder	14.34	13.61	36	13905	31652	34911338
Therapeutic response decreased	14.01	13.61	34	13907	29279	34913711
Lacrimation increased	13.84	13.61	17	13924	8465	34934525
Interstitial lung disease	13.74	13.61	57	13884	65225	34877765

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Urticaria	163.93	11.10	312	38893	184889	79520294
Pruritus	141.73	11.10	471	38734	394177	79311006
Lip swelling	112.79	11.10	119	39086	40792	79664391
Dermatitis atopic	110.03	11.10	66	39139	9990	79695193
Toxicity to various agents	100.16	11.10	41	39164	421499	79283684
Pharyngeal swelling	75.09	11.10	47	39158	7672	79697511
General physical health deterioration	73.52	11.10	22	39183	275216	79429967
Rash	68.88	11.10	503	38702	577855	79127328
Swelling face	64.16	11.10	121	39084	71091	79634092
Anaphylactic reaction	61.90	11.10	131	39074	83612	79621571
Contraindicated product administered	61.67	11.10	4	39201	157534	79547649
Synovitis	61.55	11.10	3	39202	150731	79554452
Angioedema	58.60	11.10	121	39084	75914	79629269
Treatment failure	52.63	11.10	10	39195	170476	79534707
Headache	50.64	11.10	517	38688	653255	79051928
Asthma	49.88	11.10	163	39042	134932	79570251
Seasonal allergy	49.31	11.10	50	39155	16356	79688827
Completed suicide	49.14	11.10	30	39175	245737	79459446
Hypotension	46.81	11.10	91	39114	440226	79264957
Drug abuse	45.28	11.10	12	39193	162679	79542504
Eye pruritus	43.28	11.10	52	39153	20518	79684665
Feeling abnormal	41.81	11.10	172	39033	159027	79546156
COVID-19	41.13	11.10	170	39035	157504	79547679
Drug eruption	40.00	11.10	75	39130	43860	79661323
Sinusitis	38.49	11.10	194	39011	195307	79509876
Throat tightness	37.92	11.10	57	39148	27850	79677333
Dry skin	37.70	11.10	95	39110	67900	79637283
Therapeutic product effect decreased	35.64	11.10	18	39187	163845	79541338
Hand deformity	34.50	11.10	5	39200	103914	79601269
Drug interaction	34.36	11.10	98	39107	415085	79290098
Product dose omission issue	33.89	11.10	223	38982	247314	79457869
Systemic lupus erythematosus	31.75	11.10	10	39195	121139	79584044
Eye swelling	31.69	11.10	51	39154	26417	79678766
Joint swelling	31.22	11.10	59	39146	288587	79416596
Mast cell activation syndrome	30.64	11.10	12	39193	708	79704475
Hepatic function abnormal	30.45	11.10	92	39113	73015	79632168
Dizziness	29.78	11.10	392	38813	526049	79179134
Rash pruritic	28.77	11.10	89	39116	71540	79633643
Chest discomfort	28.58	11.10	139	39066	137905	79567278
Skin exfoliation	28.50	11.10	75	39130	55025	79650158
Rash macular	28.41	11.10	51	39154	28848	79676335
Insomnia	28.35	11.10	212	38993	244958	79460225
Alopecia universalis	28.21	11.10	9	39196	289	79704894
Drug intolerance	27.67	11.10	55	39150	264064	79441119
Migraine	27.42	11.10	100	39105	87393	79617790
Swollen tongue	27.38	11.10	63	39142	42507	79662676
Arthropathy	27.35	11.10	28	39177	177083	79528100
Acute kidney injury	26.78	11.10	148	39057	519256	79185927
Myalgia	26.47	11.10	169	39036	185472	79519711
Overdose	26.37	11.10	31	39174	184175	79521008
Nasal congestion	26.14	11.10	90	39115	76462	79628721
Thrombocytopenia	25.48	11.10	58	39147	265201	79439982
Bronchitis	24.55	11.10	128	39077	130516	79574667
Chronic spontaneous urticaria	24.52	11.10	12	39193	1212	79703971
Upper respiratory tract infection	24.31	11.10	99	39106	91069	79614114
Dry eye	24.13	11.10	55	39150	36876	79668307
Hepatic enzyme increased	23.79	11.10	33	39172	182577	79522606
Illness	23.74	11.10	63	39142	46448	79658735
Erythema	23.54	11.10	189	39016	223101	79482082
Oropharyngeal swelling	23.49	11.10	12	39193	1328	79703855
Pemphigoid	23.30	11.10	33	39172	15282	79689901
Diarrhoea	22.85	11.10	580	38625	879909	78825274
Nasal pruritus	22.63	11.10	9	39196	553	79704630
Alopecia areata	22.53	11.10	13	39192	1830	79703353
Glossodynia	21.51	11.10	12	39193	103325	79601858
Anosmia	21.35	11.10	24	39181	8820	79696363
Renal failure	20.92	11.10	42	39163	200926	79504257
Lip discolouration	20.62	11.10	9	39196	699	79704484
Eczema	20.54	11.10	55	39150	40763	79664420
Rheumatoid arthritis	20.49	11.10	45	39160	208425	79496758
Death	20.07	11.10	180	39025	566334	79138849
Dysphonia	19.53	11.10	67	39138	56805	79648378
Genital swelling	19.52	11.10	7	39198	323	79704860
Rhinitis allergic	19.51	11.10	27	39178	12242	79692941
Skin swelling	19.46	11.10	16	39189	3998	79701185
Eye discharge	19.25	11.10	19	39186	6015	79699168
Drug ineffective	19.18	11.10	396	38809	1080517	78624666
Cough	19.01	11.10	269	38936	366520	79338663
Off label use	18.33	11.10	325	38880	906890	78798293
Injection site rash	18.05	11.10	32	39173	17922	79687261
Metabolic acidosis	18.03	11.10	9	39196	82520	79622663
Stevens-Johnson syndrome	17.94	11.10	51	39154	39115	79666068
Pruritus genital	17.91	11.10	16	39189	4470	79700713
Palpitations	17.87	11.10	115	39090	126495	79578688
Helicobacter infection	17.82	11.10	6	39199	69698	79635485
Coma	17.82	11.10	14	39191	100635	79604548
Urticaria aquagenic	17.81	11.10	4	39201	31	79705152
Cardiospasm	17.79	11.10	14	39191	3287	79701896
Urticaria cholinergic	17.70	11.10	4	39201	32	79705151
Sinus disorder	17.59	11.10	36	39169	22428	79682755
Rhinorrhoea	17.50	11.10	79	39126	75995	79629188
Multiple organ dysfunction syndrome	17.46	11.10	20	39185	120226	79584957
Genital rash	17.42	11.10	9	39196	1019	79704164
Sneezing	17.17	11.10	33	39172	19650	79685533
White blood cell count decreased	17.00	11.10	154	39051	188134	79517049
Vision blurred	16.72	11.10	99	39106	105799	79599384
Endometriosis	16.50	11.10	14	39191	3654	79701529
Essential tremor	16.48	11.10	10	39195	1545	79703638
Mucosal discolouration	16.47	11.10	8	39197	795	79704388
Hypohidrosis	16.44	11.10	6	39199	291	79704892
Product quality issue	16.34	11.10	45	39160	33895	79671288
Palmoplantar keratoderma	16.34	11.10	14	39191	3702	79701481
Nasal disorder	16.17	11.10	14	39191	3755	79701428
Sleep disorder	16.13	11.10	84	39121	85593	79619590
Sleep terror	16.04	11.10	15	39190	4443	79700740
Tinnitus	15.90	11.10	53	39152	44280	79660903
Impaired healing	15.77	11.10	12	39193	87643	79617540
Eye haematoma	15.60	11.10	5	39200	163	79705020
Hereditary angioedema	15.56	11.10	16	39189	5319	79699864
Poor quality device used	15.22	11.10	11	39194	2274	79702909
Ocular hyperaemia	15.20	11.10	39	39166	28167	79677016
Tension headache	14.79	11.10	18	39187	7193	79697990
Maternal exposure during pregnancy	14.66	11.10	28	39177	136510	79568673
Nausea	14.66	11.10	592	38613	956604	78748579
Insurance issue	14.60	11.10	16	39189	5717	79699466
C-reactive protein abnormal	14.57	11.10	3	39202	48364	79656819
Carcinoid syndrome	14.50	11.10	5	39200	205	79704978
Infective pulmonary exacerbation of cystic fibrosis	14.35	11.10	24	39181	12827	79692356
Liver injury	14.26	11.10	5	39200	56609	79648574
Neurosis	14.19	11.10	6	39199	431	79704752
Oropharyngeal spasm	14.15	11.10	6	39199	434	79704749
Wound	14.14	11.10	22	39183	116157	79589026
Oropharyngeal pain	14.03	11.10	97	39108	109256	79595927
Pharyngeal ulceration	13.97	11.10	8	39197	1111	79704072
Cardiac arrest	13.93	11.10	41	39164	172055	79533128
Skin texture abnormal	13.75	11.10	6	39199	466	79704717
Multiple allergies	13.69	11.10	21	39184	10439	79694744
International normalised ratio increased	13.53	11.10	13	39192	84708	79620475
Lactic acidosis	13.48	11.10	9	39196	70350	79634833
Exposure during pregnancy	13.44	11.10	18	39187	101114	79604069
Pain of skin	13.36	11.10	25	39180	14588	79690595
Therapeutic response unexpected	13.36	11.10	30	39175	19916	79685267
Muscle spasms	13.35	11.10	138	39067	174592	79530591
Rash erythematous	13.29	11.10	60	39145	57709	79647474
Pre-existing condition improved	13.27	11.10	15	39190	5548	79699635
Lacrimation increased	13.08	11.10	32	39173	22445	79682738
Skin oedema	13.03	11.10	9	39196	1732	79703451
Flatulence	12.68	11.10	48	39157	42676	79662507
Eczema herpeticum	12.64	11.10	5	39200	303	79704880
Urticarial vasculitis	12.53	11.10	6	39199	578	79704605
Haematoma	12.49	11.10	5	39200	52190	79652993
Cholestasis	12.46	11.10	5	39200	52104	79653079
Facial pain	12.40	11.10	22	39183	12328	79692855
Tongue discolouration	12.34	11.10	12	39193	3731	79701452
Mobility decreased	12.31	11.10	26	39179	122149	79583034
Interstitial lung disease	12.23	11.10	96	39109	112504	79592679
Confusional state	12.15	11.10	99	39106	317898	79387285
Exposure to allergen	12.15	11.10	5	39200	336	79704847
Sialoadenitis	11.91	11.10	9	39196	1992	79703191
Dermatitis allergic	11.84	11.10	27	39178	18103	79687080
Injection site urticaria	11.80	11.10	22	39183	12804	79692379
Skin weeping	11.79	11.10	7	39198	1040	79704143
Red blood cell sedimentation rate increased	11.67	11.10	4	39201	45938	79659245
Cerebral disorder	11.65	11.10	14	39191	5524	79699659
Injection site pain	11.62	11.10	106	39099	129732	79575451
Abdominal pain	11.59	11.10	129	39076	389440	79315743
Leukopenia	11.57	11.10	25	39180	116488	79588695
Concomitant disease aggravated	11.39	11.10	22	39183	13145	79692038
Drug dependence	11.35	11.10	3	39202	40766	79664417
Throat irritation	11.34	11.10	45	39160	40901	79664282
Impaired quality of life	11.20	11.10	23	39182	14363	79690820

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	R06AX26	RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Other antihistamines for systemic use
FDA MoA	N0000000190	Histamine H1 Receptor Antagonists
FDA EPC	N0000175587	Histamine-1 Receptor Antagonist
CHEBI has role	CHEBI:37955	H1 receptor antagonists
CHEBI has role	CHEBI:50857	anti-allergic drugs
MeSH PA	D018926	Anti-Allergic Agents
MeSH PA	D018494	Histamine Agents
MeSH PA	D006633	Histamine Antagonists
MeSH PA	D006634	Histamine H1 Antagonists
MeSH PA	D039563	Histamine H1 Antagonists, Non-Sedating
MeSH PA	D018377	Neurotransmitter Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Allergic rhinitis	indication	61582004
Sneezing	indication	76067001
Chronic idiopathic urticaria	indication	302162004
Seasonal allergic rhinitis	indication	367498001
Allergic conjunctivitis	indication	473460002	DOID:11204
Alopecia areata	off-label use	68225006	DOID:986
Urticaria	off-label use	126485001
Hyperthyroidism	contraindication	34486009	DOID:7998
Hypertensive disorder	contraindication	38341003	DOID:10763
Coronary arteriosclerosis	contraindication	53741008	DOID:3393
Diabetes mellitus	contraindication	73211009	DOID:9351
Kidney disease	contraindication	90708001	DOID:557
Benign prostatic hyperplasia	contraindication	266569009
Retention of urine	contraindication	267064002
Angle-closure glaucoma	contraindication	392291006	DOID:13550
Hypertensive urgency	contraindication	443482000

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.66	acidic
pKa2	8.85	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Histamine H1 receptor	GPCR	P35367	HRH1_HUMAN	ANTAGONIST	Ki	8		WOMBAT-PK	CHEMBL
Potassium voltage-gated channel subfamily H member 2	Ion channel	Q12809	KCNH2_HUMAN		IC50	4.67		CHEMBL
Multidrug resistance protein 1	Transporter	P08183	MDR1_HUMAN		Km	5.70		WOMBAT-PK
Solute carrier organic anion transporter family member 1A2	Transporter	P46721	SO1A2_HUMAN		Km	5.70		WOMBAT-PK

External reference:

ID	Source
4024052	VUID
N0000022057	NUI
D00671	KEGG_DRUG
153439-40-8	SECONDARY_CAS_RN
4021012	VANDF
4024052	VANDF
C0296800	UMLSCUI
CHEBI:5050	CHEBI
CHEMBL914	ChEMBL_ID
CHEMBL1200618	ChEMBL_ID
DB00950	DRUGBANK_ID
C093230	MESH_SUPPLEMENTAL_RECORD_UI
4819	IUPHAR_LIGAND_ID
7469	INN_ID
E6582LOH6V	UNII
3348	PUBCHEM_CID
236474	RXNORM
4726	MMSL
71159	MMSL
d04040	MMSL
006063	NDDF
006064	NDDF
108650005	SNOMEDCT_US
108653007	SNOMEDCT_US
372522002	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Good Sense Aller Ease	HUMAN OTC DRUG LABEL	1	0113-0425	TABLET, FILM COATED	60 mg	ORAL	ANDA	15 sections
good sense aller ease	HUMAN OTC DRUG LABEL	1	0113-0571	TABLET, FILM COATED	180 mg	ORAL	ANDA	15 sections
good sense aller ease	HUMAN OTC DRUG LABEL	1	0113-0847	TABLET, FILM COATED	180 mg	ORAL	ANDA	15 sections
basic care allergy	HUMAN OTC DRUG LABEL	1	0113-7425	TABLET, FILM COATED	60 mg	ORAL	ANDA	15 sections
basic care allergy	HUMAN OTC DRUG LABEL	1	0113-7571	TABLET, FILM COATED	180 mg	ORAL	ANDA	15 sections
Fexofenadine Hydrochloride and Pseudoephedrine Hydrochloride	HUMAN OTC DRUG LABEL	2	0363-0044	TABLET, EXTENDED RELEASE	60 mg	ORAL	ANDA	14 sections
Fexofenadine HCl and Pseudoephedrine HCl	HUMAN OTC DRUG LABEL	2	0363-0049	TABLET, EXTENDED RELEASE	180 mg	ORAL	ANDA	15 sections
Fexofenadine Hydrochloride and Pseudoephedrine Hydrochloride	Human OTC Drug Label	2	0363-0094	TABLET, FILM COATED, EXTENDED RELEASE	60 mg	ORAL	ANDA	11 sections
Fexofenadine Hydrochloride and Pseudoephedrine Hydrochloride	Human OTC Drug Label	2	0363-0094	TABLET, FILM COATED, EXTENDED RELEASE	60 mg	ORAL	ANDA	11 sections
Fexofenadine hydrochloride	Human OTC Drug Label	1	0363-0095	TABLET, FILM COATED	60 mg	ORAL	ANDA	13 sections
Fexofenadine hydrochloride	Human OTC Drug Label	1	0363-0097	TABLET, FILM COATED	180 mg	ORAL	ANDA	13 sections
Wal fex Allergy	HUMAN OTC DRUG LABEL	1	0363-0425	TABLET, FILM COATED	60 mg	ORAL	ANDA	15 sections
Wal Fex 24 Hour Allergy	HUMAN OTC DRUG LABEL	1	0363-0600	TABLET, FILM COATED	180 mg	ORAL	ANDA	15 sections
Fexofenadine hydrochloride	HUMAN OTC DRUG LABEL	1	0363-0783	TABLET	60 mg	ORAL	ANDA	15 sections
Fexofenadine hydrochloride	HUMAN OTC DRUG LABEL	1	0363-0783	TABLET	60 mg	ORAL	ANDA	15 sections
Wal-Fex	HUMAN OTC DRUG LABEL	1	0363-0784	TABLET	180 mg	ORAL	ANDA	16 sections
Wal-Fex	HUMAN OTC DRUG LABEL	1	0363-0784	TABLET	180 mg	ORAL	ANDA	16 sections
Indoor Outdoor Allergy Relief	HUMAN OTC DRUG LABEL	1	0363-0904	TABLET, COATED	180 mg	ORAL	ANDA	15 sections
Indoor Outdoor Allergy Relief	HUMAN OTC DRUG LABEL	1	0363-0904	TABLET, COATED	180 mg	ORAL	ANDA	15 sections
Fexofenadine HCl and Pseudoephedrine HCI	HUMAN OTC DRUG LABEL	2	0363-1606	TABLET, EXTENDED RELEASE	60 mg	ORAL	ANDA	16 sections
Fexofenadine Hydrochloride and Pseudoephedrine Hydrochloride	HUMAN OTC DRUG LABEL	2	0363-2110	TABLET, FILM COATED, EXTENDED RELEASE	60 mg	ORAL	ANDA	14 sections
Allergy Relief	HUMAN OTC DRUG LABEL	1	0363-8010	TABLET, COATED	180 mg	ORAL	ANDA	15 sections
Allergy Relief	HUMAN OTC DRUG LABEL	1	0363-8010	TABLET, COATED	180 mg	ORAL	ANDA	15 sections
Allergy Relief	HUMAN OTC DRUG LABEL	1	0363-8010	TABLET, COATED	180 mg	ORAL	ANDA	15 sections
Dye Free Wal Fexchildrens allergy	HUMAN OTC DRUG LABEL	1	0363-9230	SUSPENSION	30 mg	ORAL	ANDA	15 sections
Dye Free Wal Fexchildrens allergy	HUMAN OTC DRUG LABEL	1	0363-9230	SUSPENSION	30 mg	ORAL	ANDA	15 sections
Dye Free Wal Fexchildrens allergy	HUMAN OTC DRUG LABEL	1	0363-9230	SUSPENSION	30 mg	ORAL	ANDA	15 sections
Fexofenadine Hydrochloride	HUMAN OTC DRUG LABEL	1	0363-9898	TABLET, FILM COATED	180 mg	ORAL	ANDA	14 sections
Fexofenadine Hydrochloride	HUMAN OTC DRUG LABEL	1	0378-0781	TABLET, FILM COATED	60 mg	ORAL	ANDA	15 sections
Fexofenadine Hydrochloride	HUMAN OTC DRUG LABEL	1	0378-0782	TABLET, FILM COATED	180 mg	ORAL	ANDA	15 sections