felodipine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| calcium channel blockers, nifedipine derivatives | 1142 | 72509-76-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A dihydropyridine calcium antagonist with positive inotropic effects. It lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 5 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 0.00 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 0.25 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.87 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 15 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 4.40 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 11 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.00 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 10 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| July 25, 1991 | FDA | ASTRAZENECA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Cardiospasm | 195.02 | 15.74 | 52 | 15077 | 1855 | 63472038 |
| Palmoplantar keratoderma | 192.39 | 15.74 | 52 | 15077 | 1955 | 63471938 |
| Pruritus genital | 178.01 | 15.74 | 52 | 15077 | 2602 | 63471291 |
| Sleep terror | 177.51 | 15.74 | 52 | 15077 | 2628 | 63471265 |
| Atrial tachycardia | 154.03 | 15.74 | 52 | 15077 | 4188 | 63469705 |
| Carotid artery occlusion | 152.70 | 15.74 | 53 | 15076 | 4641 | 63469252 |
| Tension headache | 151.30 | 15.74 | 54 | 15075 | 5132 | 63468761 |
| Vasculitis | 134.74 | 15.74 | 72 | 15057 | 18137 | 63455756 |
| Anosmia | 133.10 | 15.74 | 53 | 15076 | 6807 | 63467086 |
| Muscle twitching | 126.81 | 15.74 | 71 | 15058 | 19597 | 63454296 |
| Tinnitus | 126.48 | 15.74 | 88 | 15041 | 35540 | 63438353 |
| Immunisation | 119.47 | 15.74 | 32 | 15097 | 1161 | 63472732 |
| Pain of skin | 115.18 | 15.74 | 56 | 15073 | 11578 | 63462315 |
| Facial pain | 111.11 | 15.74 | 53 | 15076 | 10508 | 63463385 |
| Lip swelling | 101.62 | 15.74 | 73 | 15056 | 30990 | 63442903 |
| Ventricular tachycardia | 99.44 | 15.74 | 61 | 15068 | 19918 | 63453975 |
| Hallucination | 98.91 | 15.74 | 91 | 15038 | 54726 | 63419167 |
| Subarachnoid haemorrhage | 98.75 | 15.74 | 54 | 15075 | 14229 | 63459664 |
| Angioedema | 93.16 | 15.74 | 83 | 15046 | 47882 | 63426011 |
| Eye pruritus | 87.84 | 15.74 | 55 | 15074 | 18616 | 63455277 |
| Blindness | 82.67 | 15.74 | 56 | 15073 | 21643 | 63452250 |
| Blood creatine increased | 77.45 | 15.74 | 34 | 15095 | 5567 | 63468326 |
| Diplopia | 75.86 | 15.74 | 55 | 15074 | 23673 | 63450220 |
| Hyponatraemia | 69.95 | 15.74 | 108 | 15021 | 111792 | 63362101 |
| Transient ischaemic attack | 68.71 | 15.74 | 63 | 15066 | 37690 | 63436203 |
| Palpitations | 65.18 | 15.74 | 105 | 15024 | 112665 | 63361228 |
| Hypopnoea | 62.18 | 15.74 | 26 | 15103 | 3780 | 63470113 |
| Drug ineffective | 59.42 | 15.74 | 99 | 15030 | 1044666 | 62429227 |
| Disturbance in attention | 58.60 | 15.74 | 58 | 15071 | 38131 | 63435762 |
| Catarrh | 56.26 | 15.74 | 19 | 15110 | 1530 | 63472363 |
| Intentional product misuse | 54.75 | 15.74 | 70 | 15059 | 60847 | 63413046 |
| Steroid dependence | 53.84 | 15.74 | 19 | 15110 | 1745 | 63472148 |
| Swollen tongue | 51.82 | 15.74 | 52 | 15077 | 34748 | 63439145 |
| Burns second degree | 51.72 | 15.74 | 19 | 15110 | 1959 | 63471934 |
| Dizziness | 51.05 | 15.74 | 220 | 14909 | 429705 | 63044188 |
| Rash papular | 49.28 | 15.74 | 36 | 15093 | 15666 | 63458227 |
| Tachycardia | 48.84 | 15.74 | 95 | 15034 | 118061 | 63355832 |
| Accidental overdose | 48.57 | 15.74 | 42 | 15087 | 23267 | 63450626 |
| Dehydration | 48.42 | 15.74 | 119 | 15010 | 173235 | 63300658 |
| Drug interaction | 47.62 | 15.74 | 141 | 14988 | 228990 | 63244903 |
| Bradycardia | 46.18 | 15.74 | 71 | 15058 | 73156 | 63400737 |
| Amnesia | 43.96 | 15.74 | 60 | 15069 | 55525 | 63418368 |
| Rectal haemorrhage | 43.51 | 15.74 | 56 | 15073 | 48974 | 63424919 |
| Nightmare | 42.88 | 15.74 | 36 | 15093 | 19158 | 63454735 |
| Drug intolerance | 41.78 | 15.74 | 11 | 15118 | 308650 | 63165243 |
| Arthropathy | 41.49 | 15.74 | 4 | 15125 | 234788 | 63239105 |
| Dry skin | 41.40 | 15.74 | 59 | 15070 | 56828 | 63417065 |
| Migraine | 41.37 | 15.74 | 82 | 15047 | 103264 | 63370629 |
| Infusion related reaction | 41.30 | 15.74 | 5 | 15124 | 245516 | 63228377 |
| Visual impairment | 41.28 | 15.74 | 73 | 15056 | 84373 | 63389520 |
| Maternal exposure during pregnancy | 40.94 | 15.74 | 3 | 15126 | 220059 | 63253834 |
| Confusional state | 40.42 | 15.74 | 136 | 14993 | 236244 | 63237649 |
| Serotonin syndrome | 39.33 | 15.74 | 41 | 15088 | 28641 | 63445252 |
| Dopamine transporter scintigraphy abnormal | 38.97 | 15.74 | 8 | 15121 | 87 | 63473806 |
| Cognitive disorder | 37.86 | 15.74 | 56 | 15073 | 55759 | 63418134 |
| Contraindicated product administered | 37.69 | 15.74 | 4 | 15125 | 217644 | 63256249 |
| Hyperhidrosis | 36.65 | 15.74 | 80 | 15049 | 107756 | 63366137 |
| Blood glucose increased | 36.63 | 15.74 | 69 | 15060 | 83687 | 63390206 |
| COVID-19 | 34.08 | 15.74 | 80 | 15049 | 113023 | 63360870 |
| Acute kidney injury | 32.88 | 15.74 | 137 | 14992 | 263278 | 63210615 |
| Myocardial infarction | 32.69 | 15.74 | 73 | 15056 | 99820 | 63374073 |
| Medication error | 31.99 | 15.74 | 50 | 15079 | 52234 | 63421659 |
| Tubulointerstitial nephritis | 31.96 | 15.74 | 31 | 15098 | 19872 | 63454021 |
| Frequent bowel movements | 31.72 | 15.74 | 33 | 15096 | 22989 | 63450904 |
| Therapeutic product effect decreased | 29.99 | 15.74 | 5 | 15124 | 193182 | 63280711 |
| Spider naevus | 29.23 | 15.74 | 7 | 15122 | 160 | 63473733 |
| Memory impairment | 28.47 | 15.74 | 71 | 15058 | 104187 | 63369706 |
| Colitis ulcerative | 28.32 | 15.74 | 33 | 15096 | 26058 | 63447835 |
| Product use issue | 27.73 | 15.74 | 9 | 15120 | 220511 | 63253382 |
| Infection | 27.70 | 15.74 | 10 | 15119 | 229163 | 63244730 |
| Discomfort | 26.73 | 15.74 | 4 | 15125 | 167370 | 63306523 |
| Hyperreflexia | 26.70 | 15.74 | 17 | 15112 | 5917 | 63467976 |
| Gingival pain | 26.26 | 15.74 | 19 | 15110 | 8143 | 63465750 |
| Parosmia | 26 | 15.74 | 17 | 15112 | 6189 | 63467704 |
| Wound | 25.85 | 15.74 | 4 | 15125 | 163259 | 63310634 |
| Heart rate increased | 25.54 | 15.74 | 64 | 15065 | 94174 | 63379719 |
| Polyuria | 25.49 | 15.74 | 19 | 15110 | 8523 | 63465370 |
| Hyperkalaemia | 25.38 | 15.74 | 46 | 15083 | 54157 | 63419736 |
| Clonus | 25.24 | 15.74 | 15 | 15114 | 4621 | 63469272 |
| IIIrd nerve paresis | 24.90 | 15.74 | 6 | 15123 | 141 | 63473752 |
| Retinal detachment | 24.15 | 15.74 | 16 | 15113 | 5953 | 63467940 |
| Cardiac murmur | 24.00 | 15.74 | 23 | 15106 | 14529 | 63459364 |
| Treatment failure | 23.52 | 15.74 | 9 | 15120 | 199034 | 63274859 |
| Capillary disorder | 22.68 | 15.74 | 5 | 15124 | 78 | 63473815 |
| Gingival hypertrophy | 22.64 | 15.74 | 10 | 15119 | 1661 | 63472232 |
| Hepatic enzyme increased | 22.53 | 15.74 | 10 | 15119 | 202318 | 63271575 |
| Muscular weakness | 22.31 | 15.74 | 72 | 15057 | 122281 | 63351612 |
| Nodal rhythm | 22.23 | 15.74 | 10 | 15119 | 1733 | 63472160 |
| Rheumatoid arthritis | 21.97 | 15.74 | 17 | 15112 | 253802 | 63220091 |
| Injection site pain | 20.96 | 15.74 | 3 | 15126 | 129797 | 63344096 |
| Swelling | 20.76 | 15.74 | 21 | 15108 | 275357 | 63198536 |
| Rhinitis | 20.73 | 15.74 | 19 | 15110 | 11347 | 63462546 |
| Chest pain | 20.72 | 15.74 | 104 | 15025 | 215855 | 63258038 |
| Ultrasound kidney abnormal | 20.37 | 15.74 | 4 | 15125 | 34 | 63473859 |
| Multiple organ dysfunction syndrome | 20.29 | 15.74 | 43 | 15086 | 56709 | 63417184 |
| Bronchiectasis | 20.22 | 15.74 | 22 | 15107 | 16120 | 63457773 |
| Therapeutic product effect incomplete | 19.94 | 15.74 | 3 | 15126 | 125053 | 63348840 |
| Eczema | 19.91 | 15.74 | 31 | 15098 | 32260 | 63441633 |
| Neonatal anuria | 18.97 | 15.74 | 4 | 15125 | 50 | 63473843 |
| Iodine allergy | 18.38 | 15.74 | 7 | 15122 | 797 | 63473096 |
| Death | 18.03 | 15.74 | 39 | 15090 | 374342 | 63099551 |
| Pupillary reflex impaired | 17.73 | 15.74 | 9 | 15120 | 2038 | 63471855 |
| Impaired quality of life | 17.64 | 15.74 | 19 | 15110 | 13764 | 63460129 |
| Sinusitis | 17.40 | 15.74 | 17 | 15112 | 226636 | 63247257 |
| Hypomagnesaemia | 16.90 | 15.74 | 27 | 15102 | 28710 | 63445183 |
| Sinus bradycardia | 16.80 | 15.74 | 19 | 15110 | 14532 | 63459361 |
| Product dose omission issue | 16.40 | 15.74 | 19 | 15110 | 234294 | 63239599 |
| Transient global amnesia | 15.96 | 15.74 | 6 | 15123 | 659 | 63473234 |
| Malaise | 15.86 | 15.74 | 160 | 14969 | 415794 | 63058099 |
| Glomerulonephritis | 15.81 | 15.74 | 8 | 15121 | 1798 | 63472095 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Cardiospasm | 228.87 | 14.92 | 66 | 16830 | 1522 | 34938513 |
| Palmoplantar keratoderma | 211.15 | 14.92 | 65 | 16831 | 1888 | 34938147 |
| Tension headache | 205.90 | 14.92 | 71 | 16825 | 2971 | 34937064 |
| Pruritus genital | 199.30 | 14.92 | 64 | 16832 | 2140 | 34937895 |
| Sleep terror | 196.13 | 14.92 | 64 | 16832 | 2254 | 34937781 |
| Facial pain | 177.61 | 14.92 | 67 | 16829 | 3637 | 34936398 |
| Atrial tachycardia | 175.02 | 14.92 | 66 | 16830 | 3579 | 34936456 |
| Carotid artery occlusion | 173.42 | 14.92 | 66 | 16830 | 3671 | 34936364 |
| Anosmia | 172.21 | 14.92 | 67 | 16829 | 3957 | 34936078 |
| Lip swelling | 160.93 | 14.92 | 99 | 16797 | 15981 | 34924054 |
| Immunisation | 156.26 | 14.92 | 45 | 16851 | 1032 | 34939003 |
| Angioedema | 155.00 | 14.92 | 135 | 16761 | 37239 | 34902796 |
| Eye pruritus | 138.14 | 14.92 | 69 | 16827 | 7420 | 34932615 |
| Pain of skin | 135.94 | 14.92 | 64 | 16832 | 6045 | 34933990 |
| Vasculitis | 119.30 | 14.92 | 72 | 16824 | 11224 | 34928811 |
| Pericarditis | 114.73 | 14.92 | 71 | 16825 | 11574 | 34928461 |
| Subarachnoid haemorrhage | 114.36 | 14.92 | 73 | 16823 | 12562 | 34927473 |
| Migraine | 112.98 | 14.92 | 82 | 16814 | 17396 | 34922639 |
| Tinnitus | 111.36 | 14.92 | 86 | 16810 | 20032 | 34920003 |
| Muscle twitching | 109.68 | 14.92 | 66 | 16830 | 10232 | 34929803 |
| Rash papular | 102.10 | 14.92 | 63 | 16833 | 10215 | 34929820 |
| Blindness | 93.88 | 14.92 | 69 | 16827 | 14917 | 34925118 |
| Palpitations | 87.21 | 14.92 | 102 | 16794 | 39884 | 34900151 |
| Dry skin | 85.82 | 14.92 | 90 | 16806 | 31197 | 34908838 |
| Diplopia | 82.47 | 14.92 | 67 | 16829 | 16776 | 34923259 |
| Transient ischaemic attack | 80.36 | 14.92 | 82 | 16814 | 27531 | 34912504 |
| Alopecia | 75.78 | 14.92 | 75 | 16821 | 24280 | 34915755 |
| Death | 72.95 | 14.92 | 52 | 16844 | 397997 | 34542038 |
| Visual impairment | 67.73 | 14.92 | 85 | 16811 | 35717 | 34904318 |
| Disturbance in attention | 64.74 | 14.92 | 71 | 16825 | 25874 | 34914161 |
| Ventricular tachycardia | 63.33 | 14.92 | 71 | 16825 | 26508 | 34913527 |
| Drug ineffective | 63.28 | 14.92 | 77 | 16819 | 456674 | 34483361 |
| Amnesia | 61.66 | 14.92 | 70 | 16826 | 26493 | 34913542 |
| Dizziness | 61.50 | 14.92 | 238 | 16658 | 218283 | 34721752 |
| Cognitive disorder | 58.91 | 14.92 | 71 | 16825 | 28622 | 34911413 |
| Muscular weakness | 58.85 | 14.92 | 117 | 16779 | 72780 | 34867255 |
| Chest pain | 51.33 | 14.92 | 156 | 16740 | 126606 | 34813429 |
| Myocardial infarction | 49.01 | 14.92 | 149 | 16747 | 120936 | 34819099 |
| Blood glucose increased | 47.85 | 14.92 | 102 | 16794 | 66616 | 34873419 |
| Abdominal discomfort | 47.04 | 14.92 | 95 | 16801 | 59740 | 34880295 |
| Memory impairment | 45.62 | 14.92 | 78 | 16818 | 43240 | 34896795 |
| Hallucination | 44.39 | 14.92 | 85 | 16811 | 51413 | 34888622 |
| Heart rate increased | 44.34 | 14.92 | 80 | 16816 | 46263 | 34893772 |
| Peripheral swelling | 43.78 | 14.92 | 107 | 16789 | 76434 | 34863601 |
| Feeling abnormal | 42.29 | 14.92 | 94 | 16802 | 63141 | 34876894 |
| Nail bed bleeding | 38.25 | 14.92 | 12 | 16884 | 371 | 34939664 |
| Hyperhidrosis | 35.26 | 14.92 | 98 | 16798 | 75594 | 34864441 |
| Intentional product misuse | 31.84 | 14.92 | 69 | 16827 | 45542 | 34894493 |
| Completed suicide | 31.25 | 14.92 | 5 | 16891 | 98163 | 34841872 |
| Gingival pain | 31.04 | 14.92 | 19 | 16877 | 3033 | 34937002 |
| Tubulointerstitial nephritis | 30.68 | 14.92 | 44 | 16852 | 20980 | 34919055 |
| Product dose omission issue | 30.37 | 14.92 | 10 | 16886 | 119701 | 34820334 |
| COVID-19 | 29.09 | 14.92 | 93 | 16803 | 77457 | 34862578 |
| Febrile neutropenia | 28.97 | 14.92 | 15 | 16881 | 136834 | 34803201 |
| Adverse drug reaction | 28.49 | 14.92 | 51 | 16845 | 29291 | 34910744 |
| Abdominal pain upper | 27.97 | 14.92 | 87 | 16809 | 71403 | 34868632 |
| Burns second degree | 25.64 | 14.92 | 12 | 16884 | 1117 | 34938918 |
| Tachycardia | 25.11 | 14.92 | 94 | 16802 | 84678 | 34855357 |
| Catarrh | 23.84 | 14.92 | 11 | 16885 | 991 | 34939044 |
| Orthostatic hypotension | 23.83 | 14.92 | 44 | 16852 | 25875 | 34914160 |
| Swollen tongue | 23.44 | 14.92 | 32 | 16864 | 14573 | 34925462 |
| Daydreaming | 22.81 | 14.92 | 9 | 16887 | 551 | 34939484 |
| Steroid dependence | 22.28 | 14.92 | 12 | 16884 | 1505 | 34938530 |
| Oedema | 22.05 | 14.92 | 60 | 16836 | 45681 | 34894354 |
| Insomnia | 22.01 | 14.92 | 104 | 16792 | 103803 | 34836232 |
| Syncope | 21.96 | 14.92 | 95 | 16801 | 91356 | 34848679 |
| International normalised ratio increased | 21.75 | 14.92 | 61 | 16835 | 47266 | 34892769 |
| Liver function test abnormal | 21.67 | 14.92 | 47 | 16849 | 31027 | 34909008 |
| Pleuritic pain | 21.48 | 14.92 | 16 | 16880 | 3525 | 34936510 |
| Off label use | 21.10 | 14.92 | 118 | 16778 | 419406 | 34520629 |
| Intentional product use issue | 20.86 | 14.92 | 70 | 16826 | 59746 | 34880289 |
| Dehydration | 20.58 | 14.92 | 120 | 16776 | 129849 | 34810186 |
| Scrotal oedema | 20.20 | 14.92 | 12 | 16884 | 1814 | 34938221 |
| Anxiety | 19.96 | 14.92 | 98 | 16798 | 99330 | 34840705 |
| Sleep inertia | 18.92 | 14.92 | 4 | 16892 | 23 | 34940012 |
| Disease progression | 18.56 | 14.92 | 15 | 16881 | 108062 | 34831973 |
| Septic shock | 18.21 | 14.92 | 6 | 16890 | 71828 | 34868207 |
| Hypopnoea | 17.72 | 14.92 | 12 | 16884 | 2277 | 34937758 |
| Pneumonia | 17.67 | 14.92 | 103 | 16793 | 362524 | 34577511 |
| Atrioventricular block first degree | 17.54 | 14.92 | 18 | 16878 | 6074 | 34933961 |
| Pruritus | 17.49 | 14.92 | 123 | 16773 | 141858 | 34798177 |
| Parosmia | 17.09 | 14.92 | 12 | 16884 | 2413 | 34937622 |
| Bradycardia | 17.08 | 14.92 | 77 | 16819 | 75341 | 34864694 |
| Drug abuse | 16.71 | 14.92 | 14 | 16882 | 99082 | 34840953 |
| Pain | 16.45 | 14.92 | 161 | 16735 | 204514 | 34735521 |
| Leukopenia | 16.38 | 14.92 | 5 | 16891 | 62851 | 34877184 |
| Swelling face | 16.17 | 14.92 | 35 | 16861 | 23070 | 34916965 |
| Faeces discoloured | 15.92 | 14.92 | 27 | 16869 | 14851 | 34925184 |
| Interstitial lung disease | 15.61 | 14.92 | 6 | 16890 | 65276 | 34874759 |
| Dyspnoea | 15.60 | 14.92 | 262 | 16634 | 376520 | 34563515 |
| External ear pain | 15.08 | 14.92 | 3 | 16893 | 12 | 34940023 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Cardiospasm | 410.82 | 14.58 | 115 | 28951 | 3186 | 79712136 |
| Palmoplantar keratoderma | 392.91 | 14.58 | 114 | 28952 | 3602 | 79711720 |
| Sleep terror | 368.18 | 14.58 | 113 | 28953 | 4345 | 79710977 |
| Pruritus genital | 367.48 | 14.58 | 113 | 28953 | 4373 | 79710949 |
| Tension headache | 349.07 | 14.58 | 122 | 28944 | 7089 | 79708233 |
| Atrial tachycardia | 323.61 | 14.58 | 115 | 28951 | 7018 | 79708304 |
| Carotid artery occlusion | 319.52 | 14.58 | 116 | 28950 | 7531 | 79707791 |
| Anosmia | 303.08 | 14.58 | 116 | 28950 | 8728 | 79706594 |
| Immunisation | 267.39 | 14.58 | 75 | 28991 | 2092 | 79713230 |
| Facial pain | 262.37 | 14.58 | 115 | 28951 | 12235 | 79703087 |
| Lip swelling | 251.76 | 14.58 | 167 | 28899 | 40744 | 79674578 |
| Vasculitis | 248.63 | 14.58 | 139 | 28927 | 24963 | 79690359 |
| Angioedema | 247.65 | 14.58 | 212 | 28854 | 75823 | 79639499 |
| Pain of skin | 246.93 | 14.58 | 116 | 28950 | 14497 | 79700825 |
| Muscle twitching | 236.79 | 14.58 | 134 | 28932 | 24630 | 79690692 |
| Tinnitus | 227.96 | 14.58 | 162 | 28904 | 44171 | 79671151 |
| Eye pruritus | 220.47 | 14.58 | 120 | 28946 | 20450 | 79694872 |
| Subarachnoid haemorrhage | 208.92 | 14.58 | 123 | 28943 | 24342 | 79690980 |
| Blindness | 182.22 | 14.58 | 119 | 28947 | 28264 | 79687058 |
| Diplopia | 159.91 | 14.58 | 117 | 28949 | 33349 | 79681973 |
| Ventricular tachycardia | 159.53 | 14.58 | 128 | 28938 | 41807 | 79673515 |
| Transient ischaemic attack | 155.56 | 14.58 | 139 | 28927 | 52556 | 79662766 |
| Hallucination | 149.51 | 14.58 | 170 | 28896 | 85575 | 79629747 |
| Rash papular | 145.86 | 14.58 | 94 | 28972 | 21822 | 79693500 |
| Disturbance in attention | 130.51 | 14.58 | 124 | 28942 | 50677 | 79664645 |
| Dry skin | 129.16 | 14.58 | 141 | 28925 | 67854 | 79647468 |
| Migraine | 127.01 | 14.58 | 158 | 28908 | 87335 | 79627987 |
| Palpitations | 123.97 | 14.58 | 189 | 28877 | 126421 | 79588901 |
| Amnesia | 113.27 | 14.58 | 127 | 28939 | 62930 | 79652392 |
| Drug ineffective | 106.13 | 14.58 | 144 | 28922 | 1080769 | 78634553 |
| Visual impairment | 103.85 | 14.58 | 147 | 28919 | 91984 | 79623338 |
| Blood glucose increased | 97.85 | 14.58 | 161 | 28905 | 114814 | 79600508 |
| Dizziness | 93.25 | 14.58 | 409 | 28657 | 526032 | 79189290 |
| Cognitive disorder | 93.12 | 14.58 | 121 | 28945 | 69805 | 79645517 |
| Myocardial infarction | 89.12 | 14.58 | 203 | 28863 | 183926 | 79531396 |
| Muscular weakness | 82.02 | 14.58 | 181 | 28885 | 160548 | 79554774 |
| Intentional product misuse | 81.96 | 14.58 | 134 | 28932 | 95031 | 79620291 |
| Memory impairment | 72.53 | 14.58 | 139 | 28927 | 111595 | 79603727 |
| Dehydration | 71.71 | 14.58 | 226 | 28840 | 247961 | 79467361 |
| Hyperhidrosis | 69.95 | 14.58 | 164 | 28902 | 151328 | 79563994 |
| Heart rate increased | 66.20 | 14.58 | 140 | 28926 | 120584 | 79594738 |
| Tachycardia | 65.88 | 14.58 | 177 | 28889 | 177591 | 79537731 |
| COVID-19 | 65.64 | 14.58 | 164 | 28902 | 157510 | 79557812 |
| Catarrh | 65.52 | 14.58 | 26 | 29040 | 2152 | 79713170 |
| Hypopnoea | 65.28 | 14.58 | 34 | 29032 | 5295 | 79710027 |
| Chest pain | 64.79 | 14.58 | 238 | 28828 | 282066 | 79433256 |
| Burns second degree | 64.12 | 14.58 | 27 | 29039 | 2601 | 79712721 |
| Steroid dependence | 64.10 | 14.58 | 27 | 29039 | 2603 | 79712719 |
| Hyponatraemia | 61.85 | 14.58 | 173 | 28893 | 177675 | 79537647 |
| Swollen tongue | 60.33 | 14.58 | 76 | 28990 | 42494 | 79672828 |
| Bradycardia | 59.60 | 14.58 | 144 | 28922 | 135413 | 79579909 |
| Death | 57.89 | 14.58 | 73 | 28993 | 566441 | 79148881 |
| Pericarditis | 57.28 | 14.58 | 121 | 28945 | 104115 | 79611207 |
| Blood creatine increased | 54.29 | 14.58 | 37 | 29029 | 9418 | 79705904 |
| Tubulointerstitial nephritis | 53.77 | 14.58 | 68 | 28998 | 38167 | 79677155 |
| Feeling abnormal | 53.52 | 14.58 | 153 | 28913 | 159046 | 79556276 |
| Accidental overdose | 53.46 | 14.58 | 69 | 28997 | 39512 | 79675810 |
| Infusion related reaction | 50.66 | 14.58 | 11 | 29055 | 230226 | 79485096 |
| Gingival pain | 48.81 | 14.58 | 34 | 29032 | 8964 | 79706358 |
| Nightmare | 47.98 | 14.58 | 53 | 29013 | 25808 | 79689514 |
| Drug intolerance | 46.54 | 14.58 | 19 | 29047 | 264100 | 79451222 |
| Rectal haemorrhage | 43.57 | 14.58 | 90 | 28976 | 76210 | 79639112 |
| Adverse drug reaction | 43.56 | 14.58 | 83 | 28983 | 66309 | 79649013 |
| Confusional state | 41.70 | 14.58 | 227 | 28839 | 317770 | 79397552 |
| Parosmia | 39.21 | 14.58 | 27 | 29039 | 6987 | 79708335 |
| Maternal exposure during pregnancy | 38.38 | 14.58 | 3 | 29063 | 136535 | 79578787 |
| Therapeutic product effect incomplete | 37.44 | 14.58 | 4 | 29062 | 141641 | 79573681 |
| Product dose omission issue | 37.26 | 14.58 | 22 | 29044 | 247515 | 79467807 |
| Febrile neutropenia | 36.98 | 14.58 | 19 | 29047 | 230980 | 79484342 |
| Arthropathy | 35.96 | 14.58 | 10 | 29056 | 177101 | 79538221 |
| Alopecia | 35.78 | 14.58 | 173 | 28893 | 231182 | 79484140 |
| Contraindicated product administered | 35.73 | 14.58 | 7 | 29059 | 157531 | 79557791 |
| Product use issue | 35.51 | 14.58 | 16 | 29050 | 209806 | 79505516 |
| Nail bed bleeding | 34.71 | 14.58 | 12 | 29054 | 674 | 79714648 |
| Scrotal oedema | 34.43 | 14.58 | 15 | 29051 | 1570 | 79713752 |
| Infection | 34.29 | 14.58 | 23 | 29043 | 241689 | 79473633 |
| Therapeutic product effect decreased | 33.74 | 14.58 | 9 | 29057 | 163854 | 79551468 |
| Hyperkalaemia | 33.74 | 14.58 | 105 | 28961 | 114293 | 79601029 |
| Anxiety | 33.64 | 14.58 | 179 | 28887 | 248333 | 79466989 |
| Completed suicide | 32.75 | 14.58 | 25 | 29041 | 245742 | 79469580 |
| Gingival hypertrophy | 32.74 | 14.58 | 18 | 29048 | 3124 | 79712198 |
| Insomnia | 32.11 | 14.58 | 175 | 28891 | 244995 | 79470327 |
| Cardiac murmur | 32.10 | 14.58 | 34 | 29032 | 15790 | 79699532 |
| Syncope | 31.29 | 14.58 | 139 | 28927 | 179310 | 79536012 |
| Injection site pain | 31.12 | 14.58 | 5 | 29061 | 129833 | 79585489 |
| Peripheral swelling | 31.07 | 14.58 | 186 | 28880 | 269431 | 79445891 |
| Dyspnoea | 30.78 | 14.58 | 460 | 28606 | 856565 | 78858757 |
| Hepatic enzyme increased | 30.78 | 14.58 | 14 | 29052 | 182596 | 79532726 |
| Treatment failure | 30.45 | 14.58 | 12 | 29054 | 170474 | 79544848 |
| Abdominal pain upper | 30.14 | 14.58 | 161 | 28905 | 223658 | 79491664 |
| Sinusitis | 28.54 | 14.58 | 18 | 29048 | 195483 | 79519839 |
| Intentional product use issue | 28.17 | 14.58 | 120 | 28946 | 151992 | 79563330 |
| Discomfort | 27.62 | 14.58 | 6 | 29060 | 125611 | 79589711 |
| Spider naevus | 26.66 | 14.58 | 7 | 29059 | 151 | 79715171 |
| Medication error | 26.05 | 14.58 | 69 | 28997 | 68573 | 79646749 |
| Nasopharyngitis | 25.57 | 14.58 | 33 | 29033 | 253848 | 79461474 |
| Abdominal discomfort | 25.17 | 14.58 | 167 | 28899 | 250560 | 79464762 |
| Drug hypersensitivity | 25.13 | 14.58 | 44 | 29022 | 298872 | 79416450 |
| Liver function test abnormal | 24.66 | 14.58 | 65 | 29001 | 64410 | 79650912 |
| Frequent bowel movements | 24.60 | 14.58 | 41 | 29025 | 29498 | 79685824 |
| Bronchiectasis | 24.14 | 14.58 | 35 | 29031 | 22351 | 79692971 |
| Rhinitis | 23.50 | 14.58 | 28 | 29038 | 14779 | 79700543 |
| Colitis ulcerative | 23.48 | 14.58 | 44 | 29022 | 34698 | 79680624 |
| Back pain | 23.32 | 14.58 | 190 | 28876 | 303990 | 79411332 |
| Pruritus | 22.40 | 14.58 | 231 | 28835 | 394417 | 79320905 |
| Exposure during pregnancy | 21.89 | 14.58 | 5 | 29061 | 101127 | 79614195 |
| International normalised ratio increased | 21.59 | 14.58 | 74 | 28992 | 84647 | 79630675 |
| Septic shock | 21.35 | 14.58 | 9 | 29057 | 122792 | 79592530 |
| Impaired quality of life | 20.88 | 14.58 | 26 | 29040 | 14360 | 79700962 |
| Daydreaming | 20.82 | 14.58 | 9 | 29057 | 924 | 79714398 |
| Disease progression | 20.67 | 14.58 | 22 | 29044 | 184340 | 79530982 |
| Thrombocytopenia | 20.57 | 14.58 | 41 | 29025 | 265218 | 79450104 |
| Off label use | 20.42 | 14.58 | 222 | 28844 | 906993 | 78808329 |
| Swelling | 19.99 | 14.58 | 30 | 29036 | 216681 | 79498641 |
| Sleep inertia | 19.90 | 14.58 | 4 | 29062 | 24 | 79715298 |
| Orthostatic hypotension | 19.85 | 14.58 | 55 | 29011 | 56109 | 79659213 |
| Faeces discoloured | 19.82 | 14.58 | 37 | 29029 | 29090 | 79686232 |
| Impaired healing | 19.65 | 14.58 | 4 | 29062 | 87651 | 79627671 |
| Neutropenia | 19.41 | 14.58 | 48 | 29018 | 287662 | 79427660 |
| Malaise | 19.12 | 14.58 | 267 | 28799 | 489602 | 79225720 |
| Polyuria | 18.46 | 14.58 | 25 | 29041 | 14989 | 79700333 |
| Weight increased | 18.15 | 14.58 | 47 | 29019 | 277339 | 79437983 |
| Mucosal inflammation | 17.91 | 14.58 | 3 | 29063 | 75577 | 79639745 |
| Malignant neoplasm progression | 17.89 | 14.58 | 14 | 29052 | 135976 | 79579346 |
| Penile oedema | 17.78 | 14.58 | 6 | 29060 | 313 | 79715009 |
| Nodal rhythm | 17.36 | 14.58 | 12 | 29054 | 3123 | 79712199 |
| Toxicity to various agents | 17.24 | 14.58 | 87 | 28979 | 421453 | 79293869 |
| Interstitial lung disease | 16.94 | 14.58 | 10 | 29056 | 112590 | 79602732 |
| Drug interaction | 16.89 | 14.58 | 228 | 28838 | 414955 | 79300367 |
| Neuropathy peripheral | 16.82 | 14.58 | 16 | 29050 | 141289 | 79574033 |
| Wound | 16.54 | 14.58 | 11 | 29055 | 116168 | 79599154 |
| Blood cholesterol increased | 16.48 | 14.58 | 5 | 29061 | 83715 | 79631607 |
| Glomerulonephritis | 16.38 | 14.58 | 12 | 29054 | 3421 | 79711901 |
| Rheumatoid arthritis | 16.35 | 14.58 | 32 | 29034 | 208438 | 79506884 |
| Vasculitic rash | 16.10 | 14.58 | 10 | 29056 | 2174 | 79713148 |
| Helicobacter infection | 16.01 | 14.58 | 3 | 29063 | 69701 | 79645621 |
| Acute kidney injury | 16.00 | 14.58 | 272 | 28794 | 519132 | 79196190 |
| Hyperreflexia | 15.23 | 14.58 | 17 | 29049 | 8368 | 79706954 |
| Stomatitis | 14.85 | 14.58 | 19 | 29047 | 146738 | 79568584 |
| Injection site erythema | 14.81 | 14.58 | 5 | 29061 | 78192 | 79637130 |
| External ear pain | 14.78 | 14.58 | 3 | 29063 | 19 | 79715303 |
| Hospitalisation | 14.70 | 14.58 | 8 | 29058 | 94228 | 79621094 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C07FB02 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS, OTHER COMBINATIONS Beta blocking agents and calcium channel blockers |
| ATC | C08CA02 | CARDIOVASCULAR SYSTEM CALCIUM CHANNEL BLOCKERS SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS Dihydropyridine derivatives |
| ATC | C09BB05 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors and calcium channel blockers |
| FDA CS | M0006414 | Dihydropyridines |
| FDA MoA | N0000000069 | Calcium Channel Antagonists |
| FDA EPC | N0000175421 | Dihydropyridine Calcium Channel Blocker |
| CHEBI has role | CHEBI:35620 | vasodilator agents |
| CHEBI has role | CHEBI:35674 | antihypertensive drugs |
| CHEBI has role | CHEBI:38070 | antiarrhythmic agent |
| CHEBI has role | CHEBI:38215 | calcium channel blockers |
| MeSH PA | D000889 | Anti-Arrhythmia Agents |
| MeSH PA | D000959 | Antihypertensive Agents |
| MeSH PA | D002121 | Calcium Channel Blockers |
| MeSH PA | D000077264 | Calcium-Regulating Hormones and Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D049990 | Membrane Transport Modulators |
| MeSH PA | D014665 | Vasodilator Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hypertensive disorder | indication | 38341003 | DOID:10763 |
| Prinzmetal angina | off-label use | 87343002 | |
| Angina pectoris | off-label use | 194828000 | |
| Raynaud's phenomenon | off-label use | 266261006 | |
| Hyperkalemia | contraindication | 14140009 | |
| Myocardial infarction | contraindication | 22298006 | DOID:5844 |
| Acute cerebrovascular insufficiency | contraindication | 29322000 | |
| Immunosuppression | contraindication | 38013005 | |
| Angioedema | contraindication | 41291007 | DOID:1558 |
| Low blood pressure | contraindication | 45007003 | |
| Chronic heart failure | contraindication | 48447003 | |
| Coronary arteriosclerosis | contraindication | 53741008 | DOID:3393 |
| Aortic valve stenosis | contraindication | 60573004 | DOID:1712 |
| Transplantation | contraindication | 77465005 | |
| Chronic idiopathic constipation | contraindication | 82934008 | |
| Hereditary angioneurotic edema | contraindication | 82966003 | DOID:14735 |
| Hyponatremia | contraindication | 89627008 | |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Disorder of connective tissue | contraindication | 105969002 | DOID:65 |
| Hypertrophic cardiomyopathy | contraindication | 233873004 | DOID:11984 |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Peripheral edema | contraindication | 271809000 | |
| Pregnancy, function | contraindication | 289908002 | |
| Renal artery stenosis | contraindication | 302233006 | |
| Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
| Bone marrow depression | contraindication | 307762000 | |
| Hemodialysis with High-Flux Membrane | contraindication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 1.68 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Voltage-dependent L-type calcium channel subunit alpha-1D | Ion channel | BLOCKER | WOMBAT-PK | CHEMBL | |||||
| Voltage-dependent L-type calcium channel subunit alpha-1C | Ion channel | BLOCKER | WOMBAT-PK | CHEMBL | |||||
| Cytochrome P450 2C9 | Enzyme | IC50 | 5.34 | DRUG MATRIX | |||||
| Voltage-dependent T-type calcium channel subunit alpha-1H | Ion channel | Ki | 5.17 | WOMBAT-PK | |||||
| Bile acid receptor | Nuclear hormone receptor | IC50 | 5.30 | CHEMBL | |||||
| Cystic fibrosis transmembrane conductance regulator | Ion channel | ACTIVATOR | Ki | 8.40 | IUPHAR | ||||
| Aldehyde oxidase | Enzyme | IC50 | 6.52 | WOMBAT-PK | |||||
| Sodium channel alpha subunits; brain (Types I, II, III) | Ion channel | IC50 | 4.43 | CHEMBL | |||||
| Adenosine receptor A3 | GPCR | Ki | 6.22 | DRUG MATRIX |
External reference:
| ID | Source |
|---|---|
| 4020159 | VUID |
| N0000148116 | NUI |
| D00319 | KEGG_DRUG |
| 4020159 | VANDF |
| C0015772 | UMLSCUI |
| CHEBI:585948 | CHEBI |
| 225 | PDB_CHEM_ID |
| CHEMBL428768 | ChEMBL_ID |
| CHEMBL1480 | ChEMBL_ID |
| DB01023 | DRUGBANK_ID |
| D015736 | MESH_DESCRIPTOR_UI |
| 3333 | PUBCHEM_CID |
| 4190 | IUPHAR_LIGAND_ID |
| 4877 | INN_ID |
| OL961R6O2C | UNII |
| 203016 | RXNORM |
| 1621 | MMSL |
| 4716 | MMSL |
| 62563 | MMSL |
| d00231 | MMSL |
| 003602 | NDDF |
| 108535009 | SNOMEDCT_US |
| 386863007 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Felodipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0603-3581 | TABLET, EXTENDED RELEASE | 2.50 mg | ORAL | ANDA | 22 sections |
| Felodipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0603-3581 | TABLET, EXTENDED RELEASE | 2.50 mg | ORAL | ANDA | 22 sections |
| Felodipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0603-3582 | TABLET, EXTENDED RELEASE | 5 mg | ORAL | ANDA | 22 sections |
| Felodipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0603-3582 | TABLET, EXTENDED RELEASE | 5 mg | ORAL | ANDA | 22 sections |
| Felodipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0603-3583 | TABLET, FILM COATED, EXTENDED RELEASE | 10 mg | ORAL | ANDA | 22 sections |
| Felodipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0603-3583 | TABLET, FILM COATED, EXTENDED RELEASE | 10 mg | ORAL | ANDA | 22 sections |
| Felodipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-132 | TABLET, EXTENDED RELEASE | 2.50 mg | ORAL | ANDA | 17 sections |
| Felodipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-132 | TABLET, EXTENDED RELEASE | 2.50 mg | ORAL | ANDA | 17 sections |
| Felodipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-133 | TABLET, EXTENDED RELEASE | 5 mg | ORAL | ANDA | 17 sections |
| Felodipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-133 | TABLET, EXTENDED RELEASE | 5 mg | ORAL | ANDA | 17 sections |
| Felodipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-134 | TABLET, EXTENDED RELEASE | 10 mg | ORAL | ANDA | 17 sections |
| Felodipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-134 | TABLET, EXTENDED RELEASE | 10 mg | ORAL | ANDA | 17 sections |
| FELODIPINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 23155-048 | TABLET, EXTENDED RELEASE | 2.50 mg | ORAL | ANDA | 10 sections |
| FELODIPINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 23155-048 | TABLET, EXTENDED RELEASE | 2.50 mg | ORAL | ANDA | 10 sections |
| FELODIPINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 23155-049 | TABLET, EXTENDED RELEASE | 5 mg | ORAL | ANDA | 10 sections |
| FELODIPINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 23155-049 | TABLET, EXTENDED RELEASE | 5 mg | ORAL | ANDA | 10 sections |
| FELODIPINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 23155-050 | TABLET, EXTENDED RELEASE | 10 mg | ORAL | ANDA | 10 sections |
| FELODIPINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 23155-050 | TABLET, EXTENDED RELEASE | 10 mg | ORAL | ANDA | 10 sections |
| Felodipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-2421 | TABLET, FILM COATED, EXTENDED RELEASE | 10 mg | ORAL | ANDA | 24 sections |
| Felodipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-4808 | TABLET, EXTENDED RELEASE | 10 mg | ORAL | ANDA | 19 sections |
| Felodipine | Human Prescription Drug Label | 1 | 50090-5870 | TABLET, FILM COATED, EXTENDED RELEASE | 10 mg | ORAL | ANDA | 19 sections |
| Felodipine | Human Prescription Drug Label | 1 | 50090-5870 | TABLET, FILM COATED, EXTENDED RELEASE | 10 mg | ORAL | ANDA | 19 sections |
| Felodipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51407-087 | TABLET, FILM COATED | 2.50 mg | ORAL | ANDA | 21 sections |
| Felodipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51407-088 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 21 sections |
| Felodipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51407-089 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 21 sections |
| Felodipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 53489-368 | TABLET, FILM COATED, EXTENDED RELEASE | 2.50 mg | ORAL | ANDA | 24 sections |
| Felodipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 53489-369 | TABLET, FILM COATED, EXTENDED RELEASE | 5 mg | ORAL | ANDA | 24 sections |
| Felodipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 53489-370 | TABLET, FILM COATED, EXTENDED RELEASE | 10 mg | ORAL | ANDA | 24 sections |
| Felodipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-0823 | TABLET, FILM COATED | 2.50 mg | ORAL | ANDA | 24 sections |
| Felodipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-0826 | TABLET, FILM COATED, EXTENDED RELEASE | 10 mg | ORAL | ANDA | 24 sections |