fadrozole Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
aromatase inhibitors, imidazole-triazole derivatives 1126 102676-47-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • fadrozole
  • fadrozole hydrochloride
  • fadrozole HCl
  • fadrozole monohydrochloride
  • CGS 16949A
  • CGS-16949A
A selective aromatase inhibitor effective in the treatment of estrogen-dependent disease including breast cancer.
  • Molecular weight: 223.28
  • Formula: C14H13N3
  • CLOGP: 1.77
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 41.61
  • ALOGS: -2.81
  • ROTB: 1

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018931 Antineoplastic Agents, Hormonal
MeSH PA D047072 Aromatase Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D004965 Estrogen Antagonists
MeSH PA D006727 Hormone Antagonists
MeSH PA D065088 Steroid Synthesis Inhibitors

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.74 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Aromatase Enzyme INHIBITOR Ki 10.30 CHEMBL SCIENTIFIC LITERATURE
Cytochrome P450 11B1, mitochondrial Enzyme INHIBITOR IC50 8.20 CHEMBL
Cytochrome P450 11B2, mitochondrial Enzyme INHIBITOR IC50 9.10 CHEMBL
Cytochrome P450 11B2, mitochondrial Unclassified IC50 6.72 CHEMBL

External reference:

IDSource
D02451 KEGG_DRUG
59693 PUBCHEM_CID
CHEBI:31589 CHEBI
CHEMBL9298 ChEMBL_ID
CHEMBL468419 ChEMBL_ID
H0Q44H4ECQ UNII
102676-31-3 SECONDARY_CAS_RN
6632 INN_ID
0T3 PDB_CHEM_ID
JD7 PDB_CHEM_ID
D017316 MESH_DESCRIPTOR_UI
8311 IUPHAR_LIGAND_ID

Pharmaceutical products:

None