DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
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L1000
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
fadrozole 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
aromatase inhibitors, imidazole-triazole derivatives
1126
102676-47-1
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
fadrozole
fadrozole hydrochloride
fadrozole HCl
fadrozole monohydrochloride
CGS 16949A
CGS-16949A
A selective aromatase inhibitor effective in the treatment of estrogen-dependent disease including breast cancer.
Molecular weight: 223.28
Formula: C14H13N3
CLOGP: 1.77
LIPINSKI: 0
HAC: 3
HDO: 0
TPSA: 41.61
ALOGS: -2.81
ROTB: 1
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
MeSH PA
D000970
Antineoplastic Agents
MeSH PA
D018931
Antineoplastic Agents, Hormonal
MeSH PA
D047072
Aromatase Inhibitors
MeSH PA
D004791
Enzyme Inhibitors
MeSH PA
D004965
Estrogen Antagonists
MeSH PA
D006727
Hormone Antagonists
MeSH PA
D065088
Steroid Synthesis Inhibitors
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
6.74
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Aromatase
Enzyme
P11511
CP19A_HUMAN
INHIBITOR
Ki
10.30
CHEMBL
SCIENTIFIC LITERATURE
Cytochrome P450 11B1, mitochondrial
Enzyme
P15538
C11B1_HUMAN
INHIBITOR
IC50
8.20
CHEMBL
Cytochrome P450 11B2, mitochondrial
Enzyme
P19099
C11B2_HUMAN
INHIBITOR
IC50
9.10
CHEMBL
Cytochrome P450 11B2, mitochondrial
Enzyme
C11B2_MOUSE
IC50
6.72
CHEMBL
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External reference:
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ID
Source
0T3
PDB_CHEM_ID
102676-31-3
SECONDARY_CAS_RN
59693
PUBCHEM_CID
6632
INN_ID
8311
IUPHAR_LIGAND_ID
C0117234
UMLSCUI
CHEBI:31589
CHEBI
CHEMBL468419
ChEMBL_ID
CHEMBL9298
ChEMBL_ID
D017316
MESH_DESCRIPTOR_UI
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Pharmaceutical products:
None
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fadrozole