Stem definition | Drug id | CAS RN |
---|---|---|
retinol derivatives | 1116 | 54350-48-0 |
Dose | Unit | Route |
---|---|---|
35 | mg | O |
Property | Value | Reference |
---|---|---|
MRTD (Maximum Recommended Therapeutic Daily Dose) | 4.23 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 40 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
Sept. 30, 1986 | FDA |
None
None
Source | Code | Description |
---|---|---|
ATC | D05BB01 | DERMATOLOGICALS ANTIPSORIATICS ANTIPSORIATICS FOR SYSTEMIC USE Retinoids for treatment of psoriasis |
CHEBI has role | CHEBI:50176 | desquamating agent |
MeSH PA | D003879 | Dermatologic Agents |
MeSH PA | D007641 | Keratolytic Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Psoriasis | indication | 9014002 | DOID:8893 |
Oral lichen planus | off-label use | 235049008 | |
Disorder of keratinization | off-label use | 277905003 | |
Diabetes mellitus type 2 | contraindication | 44054006 | DOID:9352 |
Corneal erosion | contraindication | 50792001 | |
Corneal opacity | contraindication | 64634000 | |
Benign intracranial hypertension | contraindication | 68267002 | DOID:11459 |
Hypertrophy of bone | contraindication | 203514008 | DOID:205 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Drug-induced hepatitis | contraindication | 235876009 | |
Pregnancy, function | contraindication | 289908002 | |
Hypertriglyceridemia | contraindication | 302870006 | |
Breastfeeding (mother) | contraindication | 413712001 |
None
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Retinoic acid receptor RXR-gamma | Nuclear hormone receptor | AGONIST | DRUGBANK | CHEMBL | |||||
Retinoic acid receptor alpha | Nuclear hormone receptor | AGONIST | WOMBAT-PK | CHEMBL |
ID | Source |
---|---|
4019511 | VUID |
N0000147631 | NUI |
D00316 | KEGG_DRUG |
4019511 | VANDF |
C0015137 | UMLSCUI |
CHEBI:4913 | CHEBI |
CHEMBL464 | ChEMBL_ID |
DB00926 | DRUGBANK_ID |
D005050 | MESH_DESCRIPTOR_UI |
5282375 | PUBCHEM_CID |
7599 | IUPHAR_LIGAND_ID |
4658 | INN_ID |
65M2UDR9AG | UNII |
220195 | RXNORM |
2306 | MMSL |
4711 | MMSL |
d01256 | MMSL |
001964 | NDDF |
108912002 | SNOMEDCT_US |
386937001 | SNOMEDCT_US |
None